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Conserved domains on  [gi|1785371997|ref|XP_031759102|]
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ankyrin repeat domain-containing protein 12 isoform X1 [Xenopus tropicalis]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat (ANK) domain-containing protein is involved in mediating protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  33435370|17176038

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
173-301 5.93e-37

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 142.02  E-value: 5.93e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  173 RQKDKVNKRNERGETPLHMAAIRGDISQVKELIRMGANVNVKDFAGWTPLHEACNMGFYDVAKVLIAAGADVNTQGLDDD 252
Cdd:COG0666    108 EAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGE 187

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1785371997  253 TPLHDAASSGHRDIVKLLLRHGGNAFQANKHGARPVDVAETEELEQLLK 301
Cdd:COG0666    188 TPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVK 236
PTZ00121 super family cl31754
MAEBL; Provisional
 716-1053 3.59e-05

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 49.37  E-value: 3.59e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  716 SKNNSSEKKVKLEKSQTKEDCS---VRENHIPIENVKDEQEEPSKLDQEKIQKEEKGKDCNSETDCLHTPKEKDTKMFPL 792
Cdd:PTZ00121  1348 AKAEAEAAADEAEAAEEKAEAAekkKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKA 1427

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  793 TVFVKEDSfpIDREIDTEKPFKEGKEKSE---KRSALKERDLEKKSIDKEKKAKSEHKSEREKVEMPEITDKSKSHLQSP 869
Cdd:PTZ00121  1428 EEKKKADE--AKKKAEEAKKADEAKKKAEeakKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKA 1505

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  870 DKLQKESDKIRASVISKKNDDKEKSKDKKERNEKDKHLGEHKLCTDRKPKHTEKDSDSSRADKAKRREKELRKKSREGDY 949
Cdd:PTZ00121  1506 AEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEE 1585

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  950 SAGASSKHGQEDRKQSGNTDSSKVLHEKPAVVKEKLKEEQQKVPEHKEKDRKDKEKDIDRYKERDKHKDKTQTNIPKLKP 1029
Cdd:PTZ00121  1586 AKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAE 1665

                          330       340
                   ....*....|....*....|....
gi 1785371997 1030 KDSEAEKCKSKLQSTKDTRPKEKR 1053
Cdd:PTZ00121  1666 EAKKAEEDKKKAEEAKKAEEDEKK 1689
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
173-301 5.93e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 142.02  E-value: 5.93e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  173 RQKDKVNKRNERGETPLHMAAIRGDISQVKELIRMGANVNVKDFAGWTPLHEACNMGFYDVAKVLIAAGADVNTQGLDDD 252
Cdd:COG0666    108 EAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGE 187

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1785371997  253 TPLHDAASSGHRDIVKLLLRHGGNAFQANKHGARPVDVAETEELEQLLK 301
Cdd:COG0666    188 TPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVK 236
Ank_2 pfam12796
Ankyrin repeats (3 copies);
189-274 2.38e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 93.26  E-value: 2.38e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  189 LHMAAIRGDISQVKELIRMGANVNVKDFAGWTPLHEACNMGFYDVAKVLIaAGADVNTQGlDDDTPLHDAASSGHRDIVK 268
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKD-NGRTALHYAARSGHLEIVK 78


                   ....*.
gi 1785371997  269 LLLRHG 274
Cdd:pfam12796   79 LLLEKG 84
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 177-291 1.50e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 84.63  E-value: 1.50e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  177 KVNKRNERGETPLHMAAIRGDISQVKELIRMGANVNVKDFAGWTPLHEACNMGFYDVAKVLIAAGADVNTQGLDDDTPLH 256
Cdd:PHA02874   116 DVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLH 195

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1785371997  257 DAASSGHRDIVKLLLRHGGNAFQANKHGARPVDVA 291
Cdd:PHA02874   196 NAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNA 230
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 185-276 8.49e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 54.25  E-value: 8.49e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  185 GETPLHMAAIRGDISQVKELIRMGANVNvkdfagwTPlhEACNMGFYDVAKVLIAAGadvntqglddDTPLHDAASSGHR 264
Cdd:cd22192     89 GETALHIAVVNQNLNLVRELIARGADVV-------SP--RATGTFFRPGPKNLIYYG----------EHPLSFAACVGNE 149

                           90
                   ....*....|..
gi 1785371997  265 DIVKLLLRHGGN 276
Cdd:cd22192    150 EIVRLLIEHGAD 161
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 250-276 9.63e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 44.12  E-value: 9.63e-06
                            10        20
                    ....*....|....*....|....*..
gi 1785371997   250 DDDTPLHDAASSGHRDIVKLLLRHGGN 276
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGAD 27
PTZ00121 PTZ00121
MAEBL; Provisional
 716-1053 3.59e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 49.37  E-value: 3.59e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  716 SKNNSSEKKVKLEKSQTKEDCS---VRENHIPIENVKDEQEEPSKLDQEKIQKEEKGKDCNSETDCLHTPKEKDTKMFPL 792
Cdd:PTZ00121  1348 AKAEAEAAADEAEAAEEKAEAAekkKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKA 1427

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  793 TVFVKEDSfpIDREIDTEKPFKEGKEKSE---KRSALKERDLEKKSIDKEKKAKSEHKSEREKVEMPEITDKSKSHLQSP 869
Cdd:PTZ00121  1428 EEKKKADE--AKKKAEEAKKADEAKKKAEeakKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKA 1505

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  870 DKLQKESDKIRASVISKKNDDKEKSKDKKERNEKDKHLGEHKLCTDRKPKHTEKDSDSSRADKAKRREKELRKKSREGDY 949
Cdd:PTZ00121  1506 AEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEE 1585

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  950 SAGASSKHGQEDRKQSGNTDSSKVLHEKPAVVKEKLKEEQQKVPEHKEKDRKDKEKDIDRYKERDKHKDKTQTNIPKLKP 1029
Cdd:PTZ00121  1586 AKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAE 1665

                          330       340
                   ....*....|....*....|....
gi 1785371997 1030 KDSEAEKCKSKLQSTKDTRPKEKR 1053
Cdd:PTZ00121  1666 EAKKAEEDKKKAEEAKKAEEDEKK 1689
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
173-301 5.93e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 142.02  E-value: 5.93e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  173 RQKDKVNKRNERGETPLHMAAIRGDISQVKELIRMGANVNVKDFAGWTPLHEACNMGFYDVAKVLIAAGADVNTQGLDDD 252
Cdd:COG0666    108 EAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGE 187

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1785371997  253 TPLHDAASSGHRDIVKLLLRHGGNAFQANKHGARPVDVAETEELEQLLK 301
Cdd:COG0666    188 TPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVK 236
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
174-302 6.22e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 133.16  E-value: 6.22e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  174 QKDKVNKRNERGETPLHMAAIRGDISQVKELIRMGANVNVKDFAGWTPLHEACNMGFYDVAKVLIAAGADVNTQGLDDDT 253
Cdd:COG0666     76 AGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNT 155

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1785371997  254 PLHDAASSGHRDIVKLLLRHGGNAFQANKHGARPVDVA----ETEELEQLLKR 302
Cdd:COG0666    156 PLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAaengHLEIVKLLLEA 208
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
178-303 1.05e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 126.99  E-value: 1.05e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  178 VNKRNERGETPLHMAAIRGDISQVKELIRMGANVNVKDFAGWTPLHEACNMGFYDVAKVLIAAGADVNTQGLDDDTPLHD 257
Cdd:COG0666    146 VNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1785371997  258 AASSGHRDIVKLLLRHGGNAFQANKHGARPVDVAETEELEQLLKRE 303
Cdd:COG0666    226 AAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLL 271
Ank_2 pfam12796
Ankyrin repeats (3 copies);
189-274 2.38e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 93.26  E-value: 2.38e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  189 LHMAAIRGDISQVKELIRMGANVNVKDFAGWTPLHEACNMGFYDVAKVLIaAGADVNTQGlDDDTPLHDAASSGHRDIVK 268
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKD-NGRTALHYAARSGHLEIVK 78


                   ....*.
gi 1785371997  269 LLLRHG 274
Cdd:pfam12796   79 LLLEKG 84
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
175-302 5.41e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 98.49  E-value: 5.41e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  175 KDKVNKRNERGETPLHMAAIRGDISQVKELIRMGANVNVKDFAGWTPLHEACNMGFYDVAKVLIAAGADVNTQGLDDDTP 254
Cdd:COG0666     44 LLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETP 123

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1785371997  255 LHDAASSGHRDIVKLLLRHGGNAFQANKHGARPVDVA----ETEELEQLLKR 302
Cdd:COG0666    124 LHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAaangNLEIVKLLLEA 175
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
178-286 2.48e-20

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 93.48  E-value: 2.48e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  178 VNKRNERGETPLHMAAIRGDISQVKELIRMGANVNVKDFAGWTPLHEACNMGFYDVAKVLIAAGADVNTQGLDDDTPLHD 257
Cdd:COG0666    179 VNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLL 258

                           90       100
                   ....*....|....*....|....*....
gi 1785371997  258 AASSGHRDIVKLLLRHGGNAFQANKHGAR 286
Cdd:COG0666    259 AAAAGAALIVKLLLLALLLLAAALLDLLT 287
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 177-291 1.50e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 84.63  E-value: 1.50e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  177 KVNKRNERGETPLHMAAIRGDISQVKELIRMGANVNVKDFAGWTPLHEACNMGFYDVAKVLIAAGADVNTQGLDDDTPLH 256
Cdd:PHA02874   116 DVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLH 195

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1785371997  257 DAASSGHRDIVKLLLRHGGNAFQANKHGARPVDVA 291
Cdd:PHA02874   196 NAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNA 230
PHA03095 PHA03095
ankyrin-like protein; Provisional
 178-290 1.19e-15

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 81.99  E-value: 1.19e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  178 VNKRNERGETPLHMAaIRGDISQVKELIRM----GANVNVKDFAGWTPLH-EACNMGFYDVAKVLIAAGADVNTQGLDDD 252
Cdd:PHA03095    40 VNFRGEYGKTPLHLY-LHYSSEKVKDIVRLlleaGADVNAPERCGFTPLHlYLYNATTLDVIKLLIKAGADVNAKDKVGR 118

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1785371997  253 TPLHDAASSG--HRDIVKLLLRHGGNAFQANKHGARPVDV 290
Cdd:PHA03095   119 TPLHVYLSGFniNPKVIRLLLRKGADVNALDLYGMTPLAV 158
Ank_2 pfam12796
Ankyrin repeats (3 copies);
178-247 1.62e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.92  E-value: 1.62e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  178 VNKRNERGETPLHMAAIRGDISQVKELIRmGANVNVKDFaGWTPLHEACNMGFYDVAKVLIAAGADVNTQ 247
Cdd:pfam12796   23 ANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVKLLLEKGADINVK 90
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 116-285 1.22e-13

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 76.48  E-value: 1.22e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  116 GSKKSTPVNILFgyplserKQMALLMQMTARDNSPDSTpnhpSQATPTQKKTPSSSTRQKDKVNkrnergETPLHMAAIR 195
Cdd:PTZ00322    23 GSRKRRAKPISF-------ERMAAIQEEIARIDTHLEA----LEATENKDATPDHNLTTEEVID------PVVAHMLTVE 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  196 -------GDISQVKELIRMGANVNVKDFAGWTPLHEACNMGFYDVAKVLIAAGADVNTQGLDDDTPLHDAASSGHRDIVK 268
Cdd:PTZ00322    86 lcqlaasGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165

                          170
                   ....*....|....*..
gi 1785371997  269 LLLRHGGNAFQANKHGA 285
Cdd:PTZ00322   166 LLSRHSQCHFELGANAK 182
PHA03095 PHA03095
ankyrin-like protein; Provisional
 178-278 2.33e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 74.68  E-value: 2.33e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  178 VNKRNERGETPLH---MAAIRGDIsqVKELIRMGANVNVKDFAGWTPLHeACNMGF---YDVAKVLIAAGADVNTQGLDD 251
Cdd:PHA03095    76 VNAPERCGFTPLHlylYNATTLDV--IKLLIKAGADVNAKDKVGRTPLH-VYLSGFninPKVIRLLLRKGADVNALDLYG 152

                           90       100
                   ....*....|....*....|....*....
gi 1785371997  252 DTPLHDAASSGHRDI--VKLLLRHGGNAF 278
Cdd:PHA03095   153 MTPLAVLLKSRNANVelLRLLIDAGADVY 181
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 120-277 4.30e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 73.55  E-value: 4.30e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  120 STPVNILFGYPLSERKQM---ALLMQMTARDNSPDSTPNHPSQATPTQKKTpsSSTRQKD------KVNKRNERGETPLH 190
Cdd:PHA03100    69 STPLHYLSNIKYNLTDVKeivKLLLEYGANVNAPDNNGITPLLYAISKKSN--SYSIVEYlldngaNVNIKNSDGENLLH 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  191 MAA--IRGDISQVKELIRMGANVNVK----------------DFAGWTPLHEACNMGFYDVAKVLIAAGADVNTQGLDDD 252
Cdd:PHA03100   147 LYLesNKIDLKILKLLIDKGVDINAKnrvnyllsygvpinikDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGD 226

                          170       180
                   ....*....|....*....|....*
gi 1785371997  253 TPLHDAASSGHRDIVKLLLRHGGNA 277
Cdd:PHA03100   227 TPLHIAILNNNKEIFKLLLNNGPSI 251
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 152-276 1.80e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 72.79  E-value: 1.80e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  152 STPNHPSQATPTQKKTPSSSTRQKDKVNKRNERGETPLHMAAIRG-DISQVKELIRMGANVNVKDFAGWTPLHEACNMGF 230
Cdd:PHA02876   274 NTPLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHQASTLDR 353

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1785371997  231 Y-DVAKVLIAAGADVNTQGLDDDTPLHDAASSGHRDIVKLLLRHGGN 276
Cdd:PHA02876   354 NkDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGAD 400
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
175-302 9.01e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 64.98  E-value: 9.01e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  175 KDKVNKRNERGETPLHMAAIRGDISQVKELIRMGANVNVKDFAGWTPLHEACNMGFYDVAKVLIAAGADVNTQGLDDDTP 254
Cdd:COG0666     11 LLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTL 90

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1785371997  255 LHDAASSGHRDIVKLLLRHGGNAFQANKHGARPVDVA----ETEELEQLLKR 302
Cdd:COG0666     91 LHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAayngNLEIVKLLLEA 142
Ank_4 pfam13637
Ankyrin repeats (many copies);
218-271 2.16e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 57.67  E-value: 2.16e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1785371997  218 GWTPLHEACNMGFYDVAKVLIAAGADVNTQGLDDDTPLHDAASSGHRDIVKLLL 271
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 178-291 7.49e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 63.44  E-value: 7.49e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  178 VNKRNERGETPLHMAAIRGDISQVKELIRMGANVNVKDFAGWTPLHEACnmgFYDVAKV-LIAAGADVNTQGLDDDTPLH 256
Cdd:PHA02874   183 ANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAI---IHNRSAIeLLINNASINDQDIDGSTPLH 259

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1785371997  257 DAAS-SGHRDIVKLLLRHGGNAFQANKHGARPVDVA 291
Cdd:PHA02874   260 HAINpPCDIDIIDILLYHKADISIKDNKGENPIDTA 295
PHA03095 PHA03095
ankyrin-like protein; Provisional
 178-293 1.75e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 62.35  E-value: 1.75e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  178 VNKRNERGETPLH--MAAIRGDISQVKELIRMGANVNVKDFAGWTPLH-----EACNMgfyDVAKVLIAAGADVNTQGLD 250
Cdd:PHA03095   110 VNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAvllksRNANV---ELLRLLIDAGADVYAVDDR 186

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1785371997  251 DDTPLHDAASSGHRD--IVKLLLRHGGNAFQANKHGARPVDVAET 293
Cdd:PHA03095   187 FRSLLHHHLQSFKPRarIVRELIRAGCDPAATDMLGNTPLHSMAT 231
PHA03095 PHA03095
ankyrin-like protein; Provisional
 197-276 1.91e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 62.35  E-value: 1.91e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  197 DISQVKELIRMGANVNVKDFAGWTPLHEACNMGFYDVAKV---LIAAGADVNTQGLDDDTPLHDAASSGHR-DIVKLLLR 272
Cdd:PHA03095    26 TVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIvrlLLEAGADVNAPERCGFTPLHLYLYNATTlDVIKLLIK 105


                   ....
gi 1785371997  273 HGGN 276
Cdd:PHA03095   106 AGAD 109
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 186-273 2.54e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 61.55  E-value: 2.54e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  186 ETPLHMAAIRGDISQVKELIRMGANVN---VKDfaGWTPLHEACNMGFYDVAKVLIAAGADVNTQGLDDDTPLHDAASSG 262
Cdd:PHA02875    69 ESELHDAVEEGDVKAVEELLDLGKFADdvfYKD--GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMG 146

                           90
                   ....*....|.
gi 1785371997  263 HRDIVKLLLRH 273
Cdd:PHA02875   147 DIKGIELLIDH 157
Ank_4 pfam13637
Ankyrin repeats (many copies);
187-238 2.83e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.59  E-value: 2.83e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1785371997  187 TPLHMAAIRGDISQVKELIRMGANVNVKDFAGWTPLHEACNMGFYDVAKVLI 238
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 118-291 4.00e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 61.62  E-value: 4.00e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  118 KKSTPVNILF--GYplsERKQMALLMQMTARDNSPDS---TPNHPSQATPTQKKTPSSSTRQKDKVNKRNERGETPLHMA 192
Cdd:PHA02876   306 KGETPLYLMAknGY---DTENIRTLIMLGADVNAADRlyiTPLHQASTLDRNKDIVITLLELGANVNARDYCDKTPIHYA 382

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  193 AIRGDISQVKELIRMGANVNVKDFAGWTPLHEA-CNMGFYDVAKVLIAAGADVNTQGLDDDTPLHDAASSGHR-DIVKLL 270
Cdd:PHA02876   383 AVRNNVVIINTLLDYGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNCKlDVIEML 462

                          170       180
                   ....*....|....*....|.
gi 1785371997  271 LRHGGNAFQANKHGARPVDVA 291
Cdd:PHA02876   463 LDNGADVNAINIQNQYPLLIA 483
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 178-274 7.89e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 60.28  E-value: 7.89e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  178 VNKRNE-RGETPLHMAAIRGDISQVKELIRMGANVNVKDFAGWTPLHEACNMGFYDVAKVLIAAGADVNTQGLDDDTPLH 256
Cdd:PHA02878   160 INMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLH 239

                           90
                   ....*....|....*....
gi 1785371997  257 DAASS-GHRDIVKLLLRHG 274
Cdd:PHA02878   240 ISVGYcKDYDILKLLLEHG 258
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 184-304 8.61e-09

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 60.65  E-value: 8.61e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  184 RGETPLHMAAIRGDISQVKELIRMGANVNVKDFAGWTPLHEACNMGFYDVAKVL--IAAGADVNT--------------- 246
Cdd:PLN03192   557 KGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILyhFASISDPHAagdllctaakrndlt 636

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1785371997  247 -------QGLDDDTPLHDAASS-------GHRDIVKLLLRHGGNAFQANKHGarpvDVAETEELEQLLKREV 304
Cdd:PLN03192   637 amkellkQGLNVDSEDHQGATAlqvamaeDHVDMVRLLIMNGADVDKANTDD----DFSPTELRELLQKREL 704
Ank_5 pfam13857
Ankyrin repeats (many copies);
178-225 1.65e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 52.35  E-value: 1.65e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1785371997  178 VNKRNERGETPLHMAAIRGDISQVKELIRMGANVNVKDFAGWTPLHEA 225
Cdd:pfam13857    9 LNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 201-291 2.15e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 59.12  E-value: 2.15e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  201 VKELIRMGANVNVKD-FAGWTPLHEACNMGFYDVAKVLIAAGADVNTQGLDDDTPLHDAASSGHRDIVKLLLRHGGNAFQ 279
Cdd:PHA02878   150 TKLLLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA 229

                           90
                   ....*....|..
gi 1785371997  280 ANKHGARPVDVA 291
Cdd:PHA02878   230 RDKCGNTPLHIS 241
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 177-246 2.32e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 58.52  E-value: 2.32e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  177 KVNKRNERGETPLHMAAIRGDISQVKELIRMGANVNVKDFAGWTPLHEACNMGFYDVAKVLIAAGADVNT 246
Cdd:PHA03100   184 PINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKT 253
PHA03095 PHA03095
ankyrin-like protein; Provisional
 143-272 5.73e-08

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 57.73  E-value: 5.73e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  143 MTARDNSPDSTPNHPSQATPTQKKTPSSSTRQKDKVNKRNERGETPLHMAAIRGDI--SQVKELIRMGANVNVKDFAGWT 220
Cdd:PHA03095   180 VYAVDDRFRSLLHHHLQSFKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCkrSLVLPLLIAGISINARNRYGQT 259

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1785371997  221 PLHEA---CNMGFYDVakvLIAAGADVNTQGLDDDTPLHDAASSGHRDIVKLLLR 272
Cdd:PHA03095   260 PLHYAavfNNPRACRR---LIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALA 311
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 146-291 1.03e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 56.81  E-value: 1.03e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  146 RDNSPDSTPNHPSQATPTQKKTPSSSTRQKdKVNKRNERGETPLHMAAIRGDISQVKELIRMGANVNVKDFAGWTPLHEA 225
Cdd:PHA02878   163 KDRHKGNTALHYATENKDQRLTELLLSYGA-NVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHIS 241

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1785371997  226 CN-MGFYDVAKVLIAAGADVNTQG-LDDDTPLHDAASSghRDIVKLLLRHGGNAFQANKHGARPVDVA 291
Cdd:PHA02878   242 VGyCKDYDILKLLLEHGVDVNAKSyILGLTALHSSIKS--ERKLKLLLEYGADINSLNSYKLTPLSSA 307
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 187-277 1.96e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 55.77  E-value: 1.96e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  187 TPLHMAAIRGDISQVKELIRMGANVNVKDFAGWTPLHEACNMGFYDVAKVLIAAGADVNTQGLDDDTPLHDAASSGHR-D 265
Cdd:PHA02875   137 SPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNKiD 216

                           90
                   ....*....|..
gi 1785371997  266 IVKLLLRHGGNA 277
Cdd:PHA02875   217 IVRLFIKRGADC 228
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
177-255 7.86e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 53.03  E-value: 7.86e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1785371997  177 KVNKRNERGETPLHMAAIRGDISQVKELIRMGANVNVKDFAGWTPLHEACNMGFYDVAKVLIAAGADVNTQGLDDDTPL 255
Cdd:COG0666    211 DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 135-255 8.07e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 54.12  E-value: 8.07e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  135 KQMALLMQMTARDNSPDSTPNHPSQATPTQKKTPSSST--RQKDKVNKRNERGETPLHMAAIR-GDISQVKELIRMGANV 211
Cdd:PHA02878   182 RLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHIllENGASTDARDKCGNTPLHISVGYcKDYDILKLLLEHGVDV 261

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1785371997  212 NVKDFA-GWTPLHEACNMGfyDVAKVLIAAGADVNTQGLDDDTPL 255
Cdd:PHA02878   262 NAKSYIlGLTALHSSIKSE--RKLKLLLEYGADINSLNSYKLTPL 304
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 185-276 8.49e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 54.25  E-value: 8.49e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  185 GETPLHMAAIRGDISQVKELIRMGANVNvkdfagwTPlhEACNMGFYDVAKVLIAAGadvntqglddDTPLHDAASSGHR 264
Cdd:cd22192     89 GETALHIAVVNQNLNLVRELIARGADVV-------SP--RATGTFFRPGPKNLIYYG----------EHPLSFAACVGNE 149

                           90
                   ....*....|..
gi 1785371997  265 DIVKLLLRHGGN 276
Cdd:cd22192    150 EIVRLLIEHGAD 161
Ank_5 pfam13857
Ankyrin repeats (many copies);
237-291 1.03e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 47.34  E-value: 1.03e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1785371997  237 LIAAG-ADVNTQGLDDDTPLHDAASSGHRDIVKLLLRHGGNAFQANKHGARPVDVA 291
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 234-302 1.10e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 53.75  E-value: 1.10e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1785371997  234 AKVLIAAGADVNTQGLDDDTPLHDAASSGHRDIVKLLLRHGGNAFQANKHGARPVDVAE---TEELEQLLKR 302
Cdd:PTZ00322    98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEengFREVVQLLSR 169
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 187-277 1.39e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 53.13  E-value: 1.39e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  187 TPLHMAAIRGDISQVKELIRMGANVNVKDFAGWTPLHEACNMGFY-----DVAKVLIAAGADVNTQGLDDDTPLHDAAS- 260
Cdd:PHA03100    37 LPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNGITPLLYAISk 116

                           90
                   ....*....|....*...
gi 1785371997  261 -SGHRDIVKLLLRHGGNA 277
Cdd:PHA03100   117 kSNSYSIVEYLLDNGANV 134
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 176-300 2.38e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 52.76  E-value: 2.38e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  176 DKVNKRNErgetplHMAAIRGDISQ-----VKELIRMGANVNVKDFAGWTPLHEACNMGFYDVAKVLIAAGADVNTQGLD 250
Cdd:PHA02876   137 DKINESIE------YMKLIKERIQQdelliAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALD 210

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1785371997  251 DDTPLHDAASSGHRDIVKLLLRHGGNafqANKHGARPVDVAETEELEQLL 300
Cdd:PHA02876   211 DLSVLECAVDSKNIDTIKAIIDNRSN---INKNDLSLLKAIRNEDLETSL 257
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 201-288 5.32e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 51.12  E-value: 5.32e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  201 VKELIRMGANVNVKDFAGWTPLHEACNMGFYDVAKVLIAAGADVNTQGLDDDTPLHDAASSGHRDIVKLLLRHGGNAFQA 280
Cdd:PHA02874   107 IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVK 186


                   ....*...
gi 1785371997  281 NKHGARPV 288
Cdd:PHA02874   187 DNNGESPL 194
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 183-276 5.48e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 51.15  E-value: 5.48e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  183 ERGETPLHMAAIRGDISQVKELIRMGANVNVKDFAGWTPLHEACNMGFYDVAKVLIAAGADVNTQGLDDDTPLHDAASSG 262
Cdd:PHA02875   100 KDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKG 179

                           90
                   ....*....|....
gi 1785371997  263 HRDIVKLLLRHGGN 276
Cdd:PHA02875   180 DIAICKMLLDSGAN 193
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 184-215 9.01e-06

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 44.20  E-value: 9.01e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1785371997  184 RGETPLHMAAIR-GDISQVKELIRMGANVNVKD 215
Cdd:pfam00023    1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 250-276 9.63e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 44.12  E-value: 9.63e-06
                            10        20
                    ....*....|....*....|....*..
gi 1785371997   250 DDDTPLHDAASSGHRDIVKLLLRHGGN 276
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGAD 27
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 178-284 1.15e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 48.28  E-value: 1.15e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  178 VNKRNERGETPLHMAAIRGDISQ--VKELIRMGANVNVKdfagwTPLHEACNMGFY---------DVAKVLIAAGADVNT 246
Cdd:PHA02859    44 VNDCNDLYETPIFSCLEKDKVNVeiLKFLIENGADVNFK-----TRDNNLSALHHYlsfnknvepEILKILIDSGSSITE 118

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1785371997  247 QGLDDDTPLHDAAS--SGHRDIVKLLLRHGGNAFQANKHG 284
Cdd:PHA02859   119 EDEDGKNLLHMYMCnfNVRINVIKLLIDSGVSFLNKDFDN 158
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 192-270 1.46e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 50.25  E-value: 1.46e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1785371997  192 AAIRGDISQVKELIRMGANVNVKDFAGWTPLHEACNMGFYDVAKVLIAAGADVNTQGLDDDTPLHDAASSGHRDIVKLL 270
Cdd:PLN03192   532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRIL 610
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 218-245 2.95e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 42.66  E-value: 2.95e-05
                           10        20
                   ....*....|....*....|....*....
gi 1785371997  218 GWTPLHEAC-NMGFYDVAKVLIAAGADVN 245
Cdd:pfam00023    2 GNTPLHLAAgRRGNLEIVKLLLSKGADVN 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 184-213 3.48e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 42.19  E-value: 3.48e-05
                            10        20        30
                    ....*....|....*....|....*....|
gi 1785371997   184 RGETPLHMAAIRGDISQVKELIRMGANVNV 213
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PTZ00121 PTZ00121
MAEBL; Provisional
 716-1053 3.59e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 49.37  E-value: 3.59e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  716 SKNNSSEKKVKLEKSQTKEDCS---VRENHIPIENVKDEQEEPSKLDQEKIQKEEKGKDCNSETDCLHTPKEKDTKMFPL 792
Cdd:PTZ00121  1348 AKAEAEAAADEAEAAEEKAEAAekkKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKA 1427

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  793 TVFVKEDSfpIDREIDTEKPFKEGKEKSE---KRSALKERDLEKKSIDKEKKAKSEHKSEREKVEMPEITDKSKSHLQSP 869
Cdd:PTZ00121  1428 EEKKKADE--AKKKAEEAKKADEAKKKAEeakKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKA 1505

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  870 DKLQKESDKIRASVISKKNDDKEKSKDKKERNEKDKHLGEHKLCTDRKPKHTEKDSDSSRADKAKRREKELRKKSREGDY 949
Cdd:PTZ00121  1506 AEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEE 1585

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  950 SAGASSKHGQEDRKQSGNTDSSKVLHEKPAVVKEKLKEEQQKVPEHKEKDRKDKEKDIDRYKERDKHKDKTQTNIPKLKP 1029
Cdd:PTZ00121  1586 AKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAE 1665

                          330       340
                   ....*....|....*....|....
gi 1785371997 1030 KDSEAEKCKSKLQSTKDTRPKEKR 1053
Cdd:PTZ00121  1666 EAKKAEEDKKKAEEAKKAEEDEKK 1689
PHA03095 PHA03095
ankyrin-like protein; Provisional
 181-276 6.76e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 47.71  E-value: 6.76e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  181 RNERGETPLHMAA--IRGDISQVKELIRMGANVNVKDFAGWTPLHEACNMGFYDVAKV--LIAAGADVNTQGLDDDTPLH 256
Cdd:PHA03095   183 VDDRFRSLLHHHLqsFKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQTPLH 262

                           90       100
                   ....*....|....*....|
gi 1785371997  257 DAASSGHRDIVKLLLRHGGN 276
Cdd:PHA03095   263 YAAVFNNPRACRRLIALGAD 282
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 218-246 9.11e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 41.09  E-value: 9.11e-05
                           10        20
                   ....*....|....*....|....*....
gi 1785371997  218 GWTPLHEACNMGFYDVAKVLIAAGADVNT 246
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 250-282 1.03e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 41.12  E-value: 1.03e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1785371997  250 DDDTPLHDAA-SSGHRDIVKLLLRHGGNAFQANK 282
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 218-245 1.04e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 41.03  E-value: 1.04e-04
                            10        20
                    ....*....|....*....|....*...
gi 1785371997   218 GWTPLHEACNMGFYDVAKVLIAAGADVN 245
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADIN 29
PHA02798 PHA02798
ankyrin-like protein; Provisional
 189-284 1.70e-04

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 46.37  E-value: 1.70e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  189 LHMAAIRGDIsqVKELIRMGANVNVKDFAGWTPLheaC----NMGFY----DVAKVLIAAGADVNTQGLDDDTPLHDAAS 260
Cdd:PHA02798    44 LQRDSPSTDI--VKLFINLGANVNGLDNEYSTPL---CtilsNIKDYkhmlDIVKILIENGADINKKNSDGETPLYCLLS 118

                           90       100
                   ....*....|....*....|....*..
gi 1785371997  261 SGH---RDIVKLLLRHGGNAFQANKHG 284
Cdd:PHA02798   119 NGYinnLEILLFMIENGADTTLLDKDG 145
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 184-213 2.31e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 39.93  E-value: 2.31e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1785371997  184 RGETPLHMAAIRGDISQVKELIRMGANVNV 213
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 722-1059 4.14e-04

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 45.81  E-value: 4.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  722 EKKVKLEKSQTKEDCSVRENHIPIENVKDE------------------QEEPSKLDQEKIQKEEKGKDCNSETDCLHTPK 783
Cdd:PTZ00108  1005 ERELARLSNKVRFIKHVINGELVITNAKKKdlvkelkklgyvrfkdiiKKKSEKITAEEEEGAEEDDEADDEDDEEELGA 1084

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  784 EKD----TKMfPLTVFVKEDsfpidreidTEKPFKEGKEKSEKRSALKERDLE---KKSIDKEKKA--KSEHKSEREKVE 854
Cdd:PTZ00108  1085 AVSydylLSM-PIWSLTKEK---------VEKLNAELEKKEKELEKLKNTTPKdmwLEDLDKFEEAleEQEEVEEKEIAK 1154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  855 ---MPEITDKSKSHLQSPDKLQKESDKIRASVISKKNDDKEKSKDKKERNEKDKHLGEHKLCTDRKPKHTEKDSDSSRAD 931
Cdd:PTZ00108  1155 eqrLKSKTKGKASKLRKPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTK 1234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  932 KAKRREKELRKKSREGDYSAGASSKHGQEDRKQSGNTDSSKvlheKPAVVKEKLKEEQQKVPEHKEKDRKDKEKDIDRYK 1011
Cdd:PTZ00108  1235 PKKSSVKRLKSKKNNSSKSSEDNDEFSSDDLSKEGKPKNAP----KRVSAVQYSPPPPSKRPDGESNGGSKPSSPTKKKV 1310

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1785371997 1012 ERDKHKDKTQTNIPKlKPKDSEAEKCKSK--------LQSTKDTRPKEKRLVNDDL 1059
Cdd:PTZ00108  1311 KKRLEGSLAALKKKK-KSEKKTARKKKSKtrvkqasaSQSSRLLRRPRKKKSDSSS 1365
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 189-274 7.93e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.18  E-value: 7.93e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  189 LHMAAIRGDISQVKELIRMGAN-VNVKDFAGWTPLHEACNMGFYDVAKVLIAAGADVNTQGLDDDTPLHDAASSGHRDIV 267
Cdd:PHA02874     5 LRMCIYSGDIEAIEKIIKNKGNcINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDII 84


                   ....*..
gi 1785371997  268 KLLLRHG 274
Cdd:PHA02874    85 KLLIDNG 91
Ank_5 pfam13857
Ankyrin repeats (many copies);
209-256 1.77e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.48  E-value: 1.77e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1785371997  209 ANVNVKDFAGWTPLHEACNMGFYDVAKVLIAAGADVNTQGLDDDTPLH 256
Cdd:pfam13857    7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
Ank_2 pfam12796
Ankyrin repeats (3 copies);
176-215 1.91e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 39.33  E-value: 1.91e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1785371997  176 DKVNKRN-ERGETPLHMAAIRGDISQVKELIRMGANVNVKD 215
Cdd:pfam12796   51 EHADVNLkDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_4 pfam13637
Ankyrin repeats (many copies);
178-205 2.47e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.64  E-value: 2.47e-03
                           10        20
                   ....*....|....*....|....*...
gi 1785371997  178 VNKRNERGETPLHMAAIRGDISQVKELI 205
Cdd:pfam13637   27 INAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 178-301 5.03e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 41.49  E-value: 5.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785371997  178 VNKRNERGETPLHMAAIRGDISQVKELIRMGANVNVKDFAGWTPLHEACNMGFYDVAKVLIAAGAD-------------- 243
Cdd:PHA02874    28 INISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDtsilpipciekdmi 107

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1785371997  244 ---------VNTQGLDDDTPLHDAASSGHRDIVKLLLRHGGNAFQANKHGARPVDVAETEELEQLLK 301
Cdd:PHA02874   108 ktildcgidVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIK 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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