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Conserved domains on  [gi|1785384531|ref|XP_031746220|]
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adenylate kinase isoenzyme 1 isoform X3 [Xenopus tropicalis]

Protein Classification

nucleoside monophosphate kinase( domain architecture ID 11492279)

nucleoside monophosphate kinase catalyzes the transfer of the terminal phosphoryl group from a nucleoside triphosphate, usually ATP, to a nucleoside monophosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 6-193 1.11e-125

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


:

Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 351.81  E-value: 1.11e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531   6 KNSKIIFVVGGPGSGKGTQCEKIVHQYGYTHLSTGDLLRAEVSSGSERGKHLSAIMEKGELVPLDTVLDMLKEAMIAKAD 85
Cdd:TIGR01360   1 AKCKIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  86 TSKGYLIDGYPREVKQGEEFEKKIGPPSLLLYIDAGSDTMVKRLLKRGETSGRADDNEATIKKRLETYYKATEPVIAMYE 165
Cdd:TIGR01360  81 TSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYE 160

                         170       180
                  ....*....|....*....|....*...
gi 1785384531 166 GRGIVRKINAEGSVDDVFKQVSTALDAL 193
Cdd:TIGR01360 161 TKGKLRKINAEGTVDDVFLQVCTAIDKL 188
 
Name Accession Description Interval E-value
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 6-193 1.11e-125

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 351.81  E-value: 1.11e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531   6 KNSKIIFVVGGPGSGKGTQCEKIVHQYGYTHLSTGDLLRAEVSSGSERGKHLSAIMEKGELVPLDTVLDMLKEAMIAKAD 85
Cdd:TIGR01360   1 AKCKIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  86 TSKGYLIDGYPREVKQGEEFEKKIGPPSLLLYIDAGSDTMVKRLLKRGETSGRADDNEATIKKRLETYYKATEPVIAMYE 165
Cdd:TIGR01360  81 TSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYE 160

                         170       180
                  ....*....|....*....|....*...
gi 1785384531 166 GRGIVRKINAEGSVDDVFKQVSTALDAL 193
Cdd:TIGR01360 161 TKGKLRKINAEGTVDDVFLQVCTAIDKL 188
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 10-182 6.67e-73

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 218.26  E-value: 6.67e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  10 IIFVVGGPGSGKGTQCEKIVHQYGYTHLSTGDLLRAEVSSGSERGKHLSAIMEKGELVPLDTVLDMLKEAMiAKADTSKG 89
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERL-KKPDCKKG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  90 YLIDGYPREVKQGEEFEKKI---GPPSLLLYIDAGSDTMVKRLLKRGET-------------------SGRADDNEATIK 147
Cdd:cd01428    80 FILDGFPRTVDQAEALDELLdegIKPDKVIELDVPDEVLIERILGRRICpvsgrvyhlgkddvtgeplSQRSDDNEETIK 159

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1785384531 148 KRLETYYKATEPVIAMYEGRGIVRKINAEGSVDDV 182
Cdd:cd01428   160 KRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
ADK pfam00406
Adenylate kinase;
13-165 2.02e-66

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 201.77  E-value: 2.02e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  13 VVGGPGSGKGTQCEKIVHQYGYTHLSTGDLLRAEVSSGSERGKHLSAIMEKGELVPLDTVLDMLKEAMiAKADTSKGYLI 92
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERL-EQNDCKNGFLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  93 DGYPREVKQGEEFE---KKIGPPSLLLYIDAGSDTMVKRLLKRGET---------------------------SGRADDN 142
Cdd:pfam00406  80 DGFPRTVPQAEALEellERGIKLDYVIEFDVPDEVLVERLTGRRIHpnsgrsyhlefnppkvpgkddvtgeplVQRSDDN 159

                         170       180
                  ....*....|....*....|...
gi 1785384531 143 EATIKKRLETYYKATEPVIAMYE 165
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYYK 182
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 9-190 2.17e-66

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 202.28  E-value: 2.17e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531   9 KIIFVvGGPGSGKGTQCEKIVHQYGYTHLSTGDLLRAEVSSGSERGKHLSAIMEKGELVPLDTVLDMLKEAmIAKADTSK 88
Cdd:COG0563     2 RIILL-GPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKER-LAQPDCAN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  89 GYLIDGYPREVKQGEEFEK---KIG-PPSLLLYIDAGSDTMVKRLLKR---------------------------GETSG 137
Cdd:COG0563    80 GFILDGFPRTVAQAEALDEllaELGiKLDAVIELDVDDEELVERLSGRrvcpncgatyhvkfnppkvegvcdkcgGELVQ 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1785384531 138 RADDNEATIKKRLETYYKATEPVIAMYEGRGIVRKINAEGSVDDVFKQVSTAL 190
Cdd:COG0563   160 RADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAIL 212
adk PRK00279
adenylate kinase; Reviewed
 9-193 4.77e-64

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 196.52  E-value: 4.77e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531   9 KIIFVvGGPGSGKGTQCEKIVHQYGYTHLSTGDLLRAEVSSGSERGKHLSAIMEKGELVPLDTVLDMLKEAmIAKADTSK 88
Cdd:PRK00279    2 RLILL-GPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKER-LAQPDCKN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  89 GYLIDGYPREVKQGEEFE---KKIGPP-SLLLYIDAGSDTMVKRLLKR---------------------------GETSG 137
Cdd:PRK00279   80 GFLLDGFPRTIPQAEALDemlKELGIKlDAVIEIDVPDEELVERLSGRricpacgrtyhvkfnppkvegkcdvcgEELIQ 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1785384531 138 RADDNEATIKKRLETYYKATEPVIAMYEGRGIVRKINAEGSVDDVFKQVSTALDAL 193
Cdd:PRK00279  160 RADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSIDEVFADILKALGKL 215
 
Name Accession Description Interval E-value
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 6-193 1.11e-125

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 351.81  E-value: 1.11e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531   6 KNSKIIFVVGGPGSGKGTQCEKIVHQYGYTHLSTGDLLRAEVSSGSERGKHLSAIMEKGELVPLDTVLDMLKEAMIAKAD 85
Cdd:TIGR01360   1 AKCKIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  86 TSKGYLIDGYPREVKQGEEFEKKIGPPSLLLYIDAGSDTMVKRLLKRGETSGRADDNEATIKKRLETYYKATEPVIAMYE 165
Cdd:TIGR01360  81 TSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYE 160

                         170       180
                  ....*....|....*....|....*...
gi 1785384531 166 GRGIVRKINAEGSVDDVFKQVSTALDAL 193
Cdd:TIGR01360 161 TKGKLRKINAEGTVDDVFLQVCTAIDKL 188
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 10-182 6.67e-73

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 218.26  E-value: 6.67e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  10 IIFVVGGPGSGKGTQCEKIVHQYGYTHLSTGDLLRAEVSSGSERGKHLSAIMEKGELVPLDTVLDMLKEAMiAKADTSKG 89
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERL-KKPDCKKG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  90 YLIDGYPREVKQGEEFEKKI---GPPSLLLYIDAGSDTMVKRLLKRGET-------------------SGRADDNEATIK 147
Cdd:cd01428    80 FILDGFPRTVDQAEALDELLdegIKPDKVIELDVPDEVLIERILGRRICpvsgrvyhlgkddvtgeplSQRSDDNEETIK 159

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1785384531 148 KRLETYYKATEPVIAMYEGRGIVRKINAEGSVDDV 182
Cdd:cd01428   160 KRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 10-186 3.08e-68

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 206.45  E-value: 3.08e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  10 IIFVVGGPGSGKGTQCEKIVHQYGYTHLSTGDLLRAEVS-SGSERGKHLSAIMEKGELVPLDTVLDMLKEAMIAkADTSK 88
Cdd:TIGR01359   1 VVFVLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKrEGSENGSLIESYIKEGKIVPSEVTVELLKKAIQE-DGSSK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  89 GYLIDGYPREVKQGEEFEKKIGP---PSLLLYIDAGSDTMVKRLLKRGETSGRADDNEATIKKRLETYYKATEPVIAMYE 165
Cdd:TIGR01359  80 KFLIDGFPRNEENLEAWEKLMDNkvnFKFVLFFDCPEETMIKRLLKRGQTSGRVDDNIETLKKRFRTYNEETLPIIEHFE 159

                         170       180
                  ....*....|....*....|.
gi 1785384531 166 GRGIVRKINAEGSVDDVFKQV 186
Cdd:TIGR01359 160 NKGKVKEINAEGSVEEVFEDV 180
ADK pfam00406
Adenylate kinase;
13-165 2.02e-66

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 201.77  E-value: 2.02e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  13 VVGGPGSGKGTQCEKIVHQYGYTHLSTGDLLRAEVSSGSERGKHLSAIMEKGELVPLDTVLDMLKEAMiAKADTSKGYLI 92
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERL-EQNDCKNGFLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  93 DGYPREVKQGEEFE---KKIGPPSLLLYIDAGSDTMVKRLLKRGET---------------------------SGRADDN 142
Cdd:pfam00406  80 DGFPRTVPQAEALEellERGIKLDYVIEFDVPDEVLVERLTGRRIHpnsgrsyhlefnppkvpgkddvtgeplVQRSDDN 159

                         170       180
                  ....*....|....*....|...
gi 1785384531 143 EATIKKRLETYYKATEPVIAMYE 165
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYYK 182
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 9-190 2.17e-66

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 202.28  E-value: 2.17e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531   9 KIIFVvGGPGSGKGTQCEKIVHQYGYTHLSTGDLLRAEVSSGSERGKHLSAIMEKGELVPLDTVLDMLKEAmIAKADTSK 88
Cdd:COG0563     2 RIILL-GPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKER-LAQPDCAN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  89 GYLIDGYPREVKQGEEFEK---KIG-PPSLLLYIDAGSDTMVKRLLKR---------------------------GETSG 137
Cdd:COG0563    80 GFILDGFPRTVAQAEALDEllaELGiKLDAVIELDVDDEELVERLSGRrvcpncgatyhvkfnppkvegvcdkcgGELVQ 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1785384531 138 RADDNEATIKKRLETYYKATEPVIAMYEGRGIVRKINAEGSVDDVFKQVSTAL 190
Cdd:COG0563   160 RADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAIL 212
adk PRK00279
adenylate kinase; Reviewed
 9-193 4.77e-64

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 196.52  E-value: 4.77e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531   9 KIIFVvGGPGSGKGTQCEKIVHQYGYTHLSTGDLLRAEVSSGSERGKHLSAIMEKGELVPLDTVLDMLKEAmIAKADTSK 88
Cdd:PRK00279    2 RLILL-GPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKER-LAQPDCKN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  89 GYLIDGYPREVKQGEEFE---KKIGPP-SLLLYIDAGSDTMVKRLLKR---------------------------GETSG 137
Cdd:PRK00279   80 GFLLDGFPRTIPQAEALDemlKELGIKlDAVIEIDVPDEELVERLSGRricpacgrtyhvkfnppkvegkcdvcgEELIQ 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1785384531 138 RADDNEATIKKRLETYYKATEPVIAMYEGRGIVRKINAEGSVDDVFKQVSTALDAL 193
Cdd:PRK00279  160 RADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSIDEVFADILKALGKL 215
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 9-191 9.43e-57

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 177.81  E-value: 9.43e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531   9 KIIFVvGGPGSGKGTQCEKIVHQYGYTHLSTGDLLRAEVSSGSERGKHLSAIMEKGELVPLDTVLDMLKEAMIAKADTSK 88
Cdd:TIGR01351   1 RLVLL-GPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNEN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  89 GYLIDGYPREVKQGEEFEKKI-GPPSLLLYIDAGSDTMVKRLLKR---------------------------GETSGRAD 140
Cdd:TIGR01351  80 GFILDGFPRTLSQAEALDALLeEPIDAVIELDVPDEELVERLSGRricpscgrvyhlkfnppkvpgcddctgELLVQRED 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1785384531 141 DNEATIKKRLETYYKATEPVIAMYEGRGIVRKINAEGSVDDVFKQVSTALD 191
Cdd:TIGR01351 160 DTEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNGPIDEVWKRILEALK 210
PLN02200 PLN02200
adenylate kinase family protein
 4-186 6.66e-52

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 166.61  E-value: 6.66e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531   4 KLKNSKIIFVVGGPGSGKGTQCEKIVHQYGYTHLSTGDLLRAEVSSGSERGKHLSAIMEKGELVPLDTVLDMLKEAMiAK 83
Cdd:PLN02200   39 KEKTPFITFVLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEM-ES 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  84 ADTSKgYLIDGYPREVKQGEEFEKKIGP-PSLLLYIDAGSDTMVKRLLKRGEtsGRADDNEATIKKRLETYYKATEPVIA 162
Cdd:PLN02200  118 SDNNK-FLIDGFPRTEENRIAFERIIGAePNVVLFFDCPEEEMVKRVLNRNQ--GRVDDNIDTIKKRLKVFNALNLPVID 194

                         170       180
                  ....*....|....*....|....
gi 1785384531 163 MYEGRGIVRKINAEGSVDDVFKQV 186
Cdd:PLN02200  195 YYSKKGKLYTINAVGTVDEIFEQV 218
PRK14531 PRK14531
adenylate kinase; Provisional
 8-191 9.95e-49

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 156.51  E-value: 9.95e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531   8 SKIIFVvGGPGSGKGTQCEKIVHQYGYTHLSTGDLLRAEVSSGSERGKHLSAIMEKGELVPLDTVLDMLKEAMiaKADTS 87
Cdd:PRK14531    3 QRLLFL-GPPGAGKGTQAARLCAAHGLRHLSTGDLLRSEVAAGSALGQEAEAVMNRGELVSDALVLAIVESQL--KALNS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  88 KGYLIDGYPREVKQGEEFEKKIG----PPSLLLYIDAGSDTMVKRLLKRgetsGRADDNEATIKKRLETYYKATEPVIAM 163
Cdd:PRK14531   80 GGWLLDGFPRTVAQAEALEPLLEelkqPIEAVVLLELDDAVLIERLLAR----GRADDNEAVIRNRLEVYREKTAPLIDH 155

                         170       180
                  ....*....|....*....|....*...
gi 1785384531 164 YEGRGIVRKINAEGSVDDVFKQVSTALD 191
Cdd:PRK14531  156 YRQRGLLQSVEAQGSIEAITERIEKVLA 183
PRK14527 PRK14527
adenylate kinase; Provisional
 6-190 2.50e-46

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 150.71  E-value: 2.50e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531   6 KNSKIIFVvGGPGSGKGTQCEKIVHQYGYTHLSTGDLLRAEVSSGSERGKHLSAIMEKGELVPLDTVLDMLKEAMiakAD 85
Cdd:PRK14527    5 KNKVVIFL-GPPGAGKGTQAERLAQELGLKKLSTGDILRDHVARGTELGQRAKPIMEAGDLVPDELILALIRDEL---AG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  86 TSKGYLI-DGYPREVKQGEEFEKKIG----PPSLLLYIDAGSDTMVKRLLKRGETSGRADDNEATIKKRLETYYKATEPV 160
Cdd:PRK14527   81 MEPVRVIfDGFPRTLAQAEALDRLLEelgaRLLAVVLLEVPDEELIRRIVERARQEGRSDDNEETVRRRQQVYREQTQPL 160

                         170       180       190
                  ....*....|....*....|....*....|
gi 1785384531 161 IAMYEGRGIVRKINAEGSVDDVFKQVSTAL 190
Cdd:PRK14527  161 VDYYEARGHLKRVDGLGTPDEVYARILKAL 190
PRK14532 PRK14532
adenylate kinase; Provisional
 10-192 1.12e-44

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 146.51  E-value: 1.12e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  10 IIFvvGGPGSGKGTQCEKIVHQYGYTHLSTGDLLRAEVSSGSERGKHLSAIMEKGELVPLDTVLDMLKEAMiAKADTSKG 89
Cdd:PRK14532    4 ILF--GPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIASGSELGQRVKGIMDRGELVSDEIVIALIEERL-PEAEAAGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  90 YLIDGYPREVKQGEEFEK-------KIgppSLLLYIDAGSDTMVKRLLKRGETSGRADDNEATIKKRLETYYKATEPVIA 162
Cdd:PRK14532   81 AIFDGFPRTVAQAEALDKmlasrgqKI---DVVIRLKVDDEALIERIVKRFEEQGRPDDNPEVFVTRLDAYNAQTAPLLP 157

                         170       180       190
                  ....*....|....*....|....*....|
gi 1785384531 163 MYEGRGIVRKINAEGSVDDVFKQVSTALDA 192
Cdd:PRK14532  158 YYAGQGKLTEVDGMGSIEAVAASIDAALEG 187
adk PRK02496
adenylate kinase; Provisional
 9-190 1.17e-41

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 138.73  E-value: 1.17e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531   9 KIIFVvGGPGSGKGTQCEKIVHQYGYTHLSTGDLLRAEVSSGSERGKHLSAIMEKGELVPLDTVLDMLKEAMiAKADTSK 88
Cdd:PRK02496    3 RLIFL-GPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQERL-QQPDAAN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  89 GYLIDGYPREVKQGEEFEK---KIGPP-SLLLYIDAGSDTMVKRLLKRgetsGRADDNEATIKKRLETYYKATEPVIAMY 164
Cdd:PRK02496   81 GWILDGFPRKVTQAAFLDEllqEIGQSgERVVNLDVPDDVVVERLLAR----GRKDDTEEVIRRRLEVYREQTAPLIDYY 156

                         170       180
                  ....*....|....*....|....*.
gi 1785384531 165 EGRGIVRKINAEGSVDDVFKQVSTAL 190
Cdd:PRK02496  157 RDRQKLLTIDGNQSVEAVTTELKAAL 182
AAA_17 pfam13207
AAA domain;
14-147 1.53e-40

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 134.29  E-value: 1.53e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  14 VGGPGSGKGTQCEKIVHQYGYTHLSTGDLLRAEVSSGsERGKHLSAiMEKGELVPLDTVLDMLKEAmIAKADTSKGYLID 93
Cdd:pfam13207   1 TGVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAKER-GLVEDRDE-MRKLPLEPQKELQKLAAER-IAEEAGEGGVIVD 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  94 GYPREVKQGEEFEK------KIGPPSLLLYIDAGSDTMVKRLLKRgETSGRADDNEATIK 147
Cdd:pfam13207  78 GHPRIKTPAGYLPGlpvevlRELKPDAIILLEADPEEILERRLKD-RTRGRDDDSEEEIR 136
PRK14528 PRK14528
adenylate kinase; Provisional
 9-182 3.41e-39

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 132.44  E-value: 3.41e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531   9 KIIFVvGGPGSGKGTQCEKIVHQYGYTHLSTGDLLRAEVSSGSERGKHLSAIMEKGELVPLDTVLDMLKEaMIAKADTSK 88
Cdd:PRK14528    3 NIIFM-GPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKD-RIREADCKN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  89 GYLIDGYPREVKQGE---EFEKKIGPP-SLLLYIDAGSDTMVKRLLKRGETSGRADDNEATIKKRLETYYKATEPVIAMY 164
Cdd:PRK14528   81 GFLLDGFPRTVEQADaldALLKNEGKSiDKAINLEVPDGELLKRLLGRAEIEGRADDNEATIKNRLDNYNKKTLPLLDFY 160

                         170
                  ....*....|....*...
gi 1785384531 165 EGRGIVRKINAEGSVDDV 182
Cdd:PRK14528  161 AAQKKLSQVNGVGSLEEV 178
PRK14530 PRK14530
adenylate kinase; Provisional
 11-192 4.65e-38

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 130.29  E-value: 4.65e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  11 IFVVGGPGSGKGTQCEKIVHQYGYTHLSTGDLLRA---------EVSSGSERgkhlsAIMEKGELVPlDTVLDMLKEAMI 81
Cdd:PRK14530    6 ILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALRAnkqmdisdmDTEYDTPG-----EYMDAGELVP-DAVVNEIVEEAL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  82 AKADtskGYLIDGYPREVKQGEEFEKkIGPPSLLLYIDAGSDTMVKRLLKR---------------------------GE 134
Cdd:PRK14530   80 SDAD---GFVLDGYPRNLEQAEYLES-ITDLDVVLYLDVSEEELVDRLTGRrvcpdcganyhvefnqpeeegvcdecgGE 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1785384531 135 TSGRADDNEATIKKRLETYYKATEPVIAMYEGRGIVRKINAEGSVDDVFKQVSTALDA 192
Cdd:PRK14530  156 LIQRDDDTEETVRERLDVFEENTEPVIEHYRDQGVLVEVDGEQTPDEVWADIQDAIDD 213
PLN02842 PLN02842
nucleotide kinase
 13-191 1.41e-37

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 135.37  E-value: 1.41e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  13 VVGGPGSGKGTQCEKIVHQYGYTHLSTGDLLRAEVSSGSERGKHLSAIMEKGELVPLDTVLDMLKEAMIAKADTSKGYLI 92
Cdd:PLN02842    2 ISGAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  93 DGYPREVKQGEEFEKKIGPPSLLLYIDAGSDTMVKRLLKR----------------GETS-------GRADDNEATIKKR 149
Cdd:PLN02842   82 DGYPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRrldpvtgkiyhiknfpPESEeikarliTRPDDTEEKVKAR 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1785384531 150 LETYYKATEPVIAMYEgrGIVRKINAEGSVDDVFKQVSTALD 191
Cdd:PLN02842  162 LQIYKKNAEAILSTYS--DIMVKIDGNRPKEVVFEEISSLLS 201
PLN02674 PLN02674
adenylate kinase
 6-190 1.81e-30

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 111.52  E-value: 1.81e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531   6 KNSKIIFVVGGPGSGKGTQCEKIVHQYGYTHLSTGDLLRAEVSSGSERGKHLSAIMEKGELVPLDTVLDMLKEAMiAKAD 85
Cdd:PLN02674   29 KPDKRLILIGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAVAAKTPLGIKAKEAMDKGELVSDDLVVGIIDEAM-KKPS 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  86 TSKGYLIDGYPREV-----------KQGEEFEK------------------------------KIGPPSLLLYIDAGSDT 124
Cdd:PLN02674  108 CQKGFILDGFPRTVvqaqkldemlaKQGAKIDKvlnfaiddaileeritgrwihpssgrtyhtKFAPPKVPGVDDVTGEP 187

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1785384531 125 MVKrllkrgetsgRADDNEATIKKRLETYYKATEPVIAMYEGRGIVRKINAEGSVDDVFKQVSTAL 190
Cdd:PLN02674  188 LIQ----------RKDDTAAVLKSRLEAFHKQTEPVIDYYAKKGVVANLHAEKPPKEVTAEVQKAL 243
PLN02459 PLN02459
probable adenylate kinase
 15-168 1.46e-26

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 101.85  E-value: 1.46e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  15 GGPGSGKGTQCEKIVHQYGYTHLSTGDLLRAEVSSGSERGKHLSAIMEKGELVPLDTVLDMLKEAMIA-KADTSKGYLID 93
Cdd:PLN02459   36 GCPGVGKGTYASRLSKLLGVPHIATGDLVREEIKSSGPLGAQLKEIVNQGKLVPDEIIFSLLSKRLEAgEEEGESGFILD 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  94 GYPREVKQGEEFEkKIGPPSLLLYIDAGSDTMVKRLLKR---GETSG--------------------------------- 137
Cdd:PLN02459  116 GFPRTVRQAEILE-GVTDIDLVVNLKLREEVLVEKCLGRricSECGKnfnvadidlkgedgrpgivmppllpppecaskl 194

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1785384531 138 --RADDNEATIKKRLETYYKATEPVIAMYEGRG 168
Cdd:PLN02459  195 itRADDTEEVVKARLRVYKEESQPVEDFYRKRG 227
PRK13808 PRK13808
adenylate kinase; Provisional
 11-193 3.74e-26

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 102.27  E-value: 3.74e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  11 IFVVGGPGSGKGTQCEKIVHQYGYTHLSTGDLLRAEVSSGSERGKHLSAIMEKGELVPLDTVLDMLKEaMIAKADTSKGY 90
Cdd:PRK13808    3 LILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISD-RIEQPDAANGF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  91 LIDGYPREVKQGEEF-----EKKIGPPSLL-LYIDAGS-----DTMVKRLLKRGETSgRADDNEATIKKRLETYYKATEP 159
Cdd:PRK13808   82 ILDGFPRTVPQAEALdallkDKQLKLDAVVeLRVNEGAllarvETRVAEMRARGEEV-RADDTPEVLAKRLASYRAQTEP 160

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1785384531 160 VIAMYEGRGIVRKINAEGSVDDVFKQVSTALDAL 193
Cdd:PRK13808  161 LVHYYSEKRKLLTVDGMMTIDEVTREIGRVLAAV 194
PRK14526 PRK14526
adenylate kinase; Provisional
 9-186 1.07e-23

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 92.99  E-value: 1.07e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531   9 KIIFVvGGPGSGKGTQCEKIVHQYGYTHLSTGDLLRAEVSSGSERGKHLSAIMEKGELVPlDTVLDMLKEAMIAKADTSK 88
Cdd:PRK14526    2 KLVFL-GPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKEIKQIVENGQLVP-DSITIKIVEDKINTIKNND 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  89 GYLIDGYPREVKQGEEFEKKIGPPSLLLYIdAGSDTMVKRLLKR---------------------------GETSGRADD 141
Cdd:PRK14526   80 NFILDGFPRNINQAKALDKFLPNIKIINFL-IDEELLIKRLSGRrickscnnifniytlptkekgicdvckGDLYQRKDD 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1785384531 142 NEATIKKRLETYYKATEPVIAMYEGRGIVRKINAEGSVDDVFKQV 186
Cdd:PRK14526  159 KEESLKTRLQEYKLQTKPLIEFYSKCNRLNNIDASKDIDEVKKKL 203
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 4-169 1.27e-21

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 87.93  E-value: 1.27e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531   4 KLKNSKIIFVVGGPGSGKGTQCEKIVHQYGYTHLSTGDLLRAEVSSGSERGKHLSAIMEKGELVPLDTVLDMLKEAMiAK 83
Cdd:PTZ00088    2 KLKGPLKIVLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEI-AK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  84 A--DTSKGYLIDGYPREVKQGEEFeKKIGPPSLLLYIDAGSDTMVKRLLKR----------------------------G 133
Cdd:PTZ00088   81 VtdDCFKGFILDGFPRNLKQCKEL-GKITNIDLFVNIYLPRNILIKKLLGRricntcnrnfniahirsdpydmppilppA 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1785384531 134 ETSG---------RADDNEATIKKRLETYYKATEPVIAMYEGRGI 169
Cdd:PTZ00088  160 DCEGckgnpklqkRSDDTEEIVAHRLNTYESTNSPIIQFFKNENC 204
PRK14529 PRK14529
adenylate kinase; Provisional
 11-182 3.87e-17

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 75.91  E-value: 3.87e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  11 IFVVGGPGSGKGTQCEKIVHQYGYTHLSTGDLLRAEVSSGSERGKHLSAIMEKGELVPLDTVLDMLKEAMiaKADTSKGY 90
Cdd:PRK14529    3 ILIFGPNGSGKGTQGALVKKKYDLAHIESGAIFREHIGGGTELGKKAKEYIDRGDLVPDDITIPMILETL--KQDGKNGW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  91 LIDGYPREVKQGEEFEKKIGPPSLLL-YI--------DAGSDTMVKRLLKR------------------------GETSG 137
Cdd:PRK14529   81 LLDGFPRNKVQAEKLWEALQKEGMKLdYVieillpreVAKNRIMGRRLCKNdnnhpnnifidaikpdgdvcrvcgGELST 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1785384531 138 RADD-NEATIKKRLETYYKA-TEPVIAMY-------EGRGIVRKINAEGSVDDV 182
Cdd:PRK14529  161 RADDqDEEAINKRHDIYYDTeTGTLAAAYffkdlaaKGSTKYIELDGEGSIDEI 214
TMPK cd01672
Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the ...
 9-192 1.62e-06

Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step in either de novo or salvage biosynthesis of thymidine triphosphate (TTP).


Pssm-ID: 238835  Cd Length: 200  Bit Score: 46.49  E-value: 1.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531   9 KIIFVVGGPGSGKGTQCEKIVHQY---GYTHLSTGDLlraevsSGSERGKHLSAIMEKGELVPLDTVLDMLKEA------ 79
Cdd:cd01672     1 MFIVFEGIDGAGKTTLIELLAERLearGYEVVLTREP------GGTPIGEAIRELLLDPEDEKMDPRAELLLFAadraqh 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  80 ---MIAKA---------DTSK-------GYLIDGYPREVKQGEEFEKKIGPPSLLLYIDAGSDTMVKRLLKRGETSGRAD 140
Cdd:cd01672    75 veeVIKPAlargkivlsDRFVdsslayqGAGRGLGEALIEALNDLATGGLKPDLTILLDIDPEVGLARIEARGRDDRDEQ 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1785384531 141 DNEATIKKRLETYYKatepVIAMYEGRGIVrkINAEGSVDDVFKQVSTALDA 192
Cdd:cd01672   155 EGLEFHERVREGYLE----LAAQEPERIIV--IDASQPLEEVLAEILKAILE 200
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 11-153 3.99e-06

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 44.61  E-value: 3.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  11 IFVVGGPGSGKGTQCEKIVHQYGYTHLSTGDLLRAEVSSGserGKHLSAIMEKGELVPlDTVLDMLKEAMIAKADTskgy 90
Cdd:pfam13671   2 ILLVGLPGSGKSTLARRLLEELGAVRLSSDDERKRLFGEG---RPSISYYTDATDRTY-ERLHELARIALRAGRPV---- 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1785384531  91 LIDG---YPREVKQGEEFEKKIGPPSLLLYIDAGSDTMVKRLLKRGETSGRADD-NEATIKKRLETY 153
Cdd:pfam13671  74 ILDAtnlRRDERARLLALAREYGVPVRIVVFEAPEEVLRERLAARARAGGDPSDvPEEVLDRQKARF 140
PRK01184 PRK01184
flagellar hook-basal body complex protein FliE;
9-141 5.10e-06

flagellar hook-basal body complex protein FliE;


Pssm-ID: 234914 [Multi-domain]  Cd Length: 184  Bit Score: 44.94  E-value: 5.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531   9 KIIFVVGGPGSGKGtQCEKIVHQYGYTHLSTGDLLRAEVssgSERGkhlsaimekgeLVPLDTVLDML------KEAMIA 82
Cdd:PRK01184    2 KIIGVVGMPGSGKG-EFSKIAREMGIPVVVMGDVIREEV---KKRG-----------LEPTDENIGKVaidlrkELGMDA 66

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1785384531  83 ---------KADTSKGYLIDGYpREVKQGEEFEKKIGPPSLLLYIDAGSDTMVKRLLKRgetsGRADD 141
Cdd:PRK01184   67 vakrtvpkiREKGDEVVVIDGV-RGDAEVEYFRKEFPEDFILIAIHAPPEVRFERLKKR----GRSDD 129
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
10-153 5.64e-05

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 41.82  E-value: 5.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  10 IIFVVGGPGSGKGTQCEKIVHQYGYTHLSTgDLLRAEVssgseRGKHLSAIMEKGELVpldtvlDMLKEAMIAKADT--S 87
Cdd:COG0645     1 LILVCGLPGSGKSTLARALAERLGAVRLRS-DVVRKRL-----FGAGLAPLERSPEAT------ARTYARLLALAREllA 68

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1785384531  88 KGY--LIDG---YPREVKQGEEFEKKIGPPSLLLYIDAGSDTMVKRLLKRGETSGRADDNEATIKKRLETY 153
Cdd:COG0645    69 AGRsvILDAtflRRAQREAFRALAEEAGAPFVLIWLDAPEEVLRERLEARNAEGGDSDATWEVLERQLAFE 139
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 10-53 5.95e-04

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 38.62  E-value: 5.95e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1785384531  10 IIFVVGGPGSGKGTQCEKIVHQYGYTHLSTGDLLRAEVSSGSER 53
Cdd:cd02020     1 IIAIDGPAGSGKSTVAKLLAKKLGLPYLDTGGIRTEEVGKLASE 44
NK cd02019
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 10-36 6.42e-03

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


Pssm-ID: 238977 [Multi-domain]  Cd Length: 69  Bit Score: 34.23  E-value: 6.42e-03
                          10        20
                  ....*....|....*....|....*..
gi 1785384531  10 IIFVVGGPGSGKGTQCEKIVHQYGYTH 36
Cdd:cd02019     1 IIAITGGSGSGKSTVAKKLAEQLGGRS 27
PRK04182 PRK04182
cytidylate kinase; Provisional
 10-44 8.64e-03

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 35.55  E-value: 8.64e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1785384531  10 IIFVVGGPGSGKGTQCEKIVHQYGYTHLSTGDLLR 44
Cdd:PRK04182    2 IITISGPPGSGKTTVARLLAEKLGLKHVSAGEIFR 36
dNK pfam01712
Deoxynucleoside kinase; This family consists of various deoxynucleoside kinases cytidine EC:2. ...
 82-156 8.68e-03

Deoxynucleoside kinase; This family consists of various deoxynucleoside kinases cytidine EC:2.7.1.74, guanosine EC:2.7.1.113, adenosine EC:2.7.1.76 and thymidine kinase EC:2.7.1.21 (which also phosphorylates deoxyuridine and deoxycytosine.) These enzymes catalyze the production of deoxynucleotide 5'-monophosphate from a deoxynucleoside. Using ATP and yielding ADP in the process.


Pssm-ID: 396326  Cd Length: 201  Bit Score: 35.76  E-value: 8.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785384531  82 AKADTSKGYLID-GYPREVKQGEEFEKKIGPPSLLLYIDAGSDTMVKRLLKRGETSgraddnEATIK----KRLETYYKA 156
Cdd:pfam01712  89 AKMLYDKGTMSDeEYKTYKDLYDNMLLEFPKPDLIIYLKTSPETCLERIKKRGRTE------EQNISldylERLHEKYEA 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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