NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1751290757|ref|XP_030790690|]
View 

ankyrin repeat and SOCS box protein 9 isoform X2 [Rhinopithecus roxellana]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat (ANK) domain-containing protein is involved in mediating protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  33435370|17176038

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
22-261 1.13e-40

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 141.63  E-value: 1.13e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  22 IRLLSNPLMSDAVSDWSPMHEAAIYGRQLSLRNLISQGWLVNIITADHVSPLHEACLGGHPSCVKILLKHGAQVNGVTTD 101
Cdd:COG0666    40 LLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKD 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 102 WHTPLFNACVSGSQDCVNLLLQHGASV-QPESDLASPIHEAARRGHVECVDSLIAYGGNIDHKISHLGTPLYLACENQQR 180
Cdd:COG0666   120 GETPLHLAAYNGNLEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHL 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 181 ACVKKLLESGADVN-QGKGQDSPLHAAARTASEELACLLMDFGADTQAKNAEGKRPVELVPPDSPLARLFLEREGASLPK 259
Cdd:COG0666   200 EIVKLLLEAGADVNaKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLA 279


                  ..
gi 1751290757 260 PK 261
Cdd:COG0666   280 AA 281
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
22-261 1.13e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 141.63  E-value: 1.13e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  22 IRLLSNPLMSDAVSDWSPMHEAAIYGRQLSLRNLISQGWLVNIITADHVSPLHEACLGGHPSCVKILLKHGAQVNGVTTD 101
Cdd:COG0666    40 LLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKD 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 102 WHTPLFNACVSGSQDCVNLLLQHGASV-QPESDLASPIHEAARRGHVECVDSLIAYGGNIDHKISHLGTPLYLACENQQR 180
Cdd:COG0666   120 GETPLHLAAYNGNLEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHL 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 181 ACVKKLLESGADVN-QGKGQDSPLHAAARTASEELACLLMDFGADTQAKNAEGKRPVELVPPDSPLARLFLEREGASLPK 259
Cdd:COG0666   200 EIVKLLLEAGADVNaKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLA 279


                  ..
gi 1751290757 260 PK 261
Cdd:COG0666   280 AA 281
Ank_2 pfam12796
Ankyrin repeats (3 copies);
73-163 5.78e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 81.70  E-value: 5.78e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  73 LHEACLGGHPSCVKILLKHGAQVNGVTTDWHTPLFNACVSGSQDCVNLLLQHgASVQPESDLASPIHEAARRGHVECVDS 152
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|.
gi 1751290757 153 LIAYGGNIDHK 163
Cdd:pfam12796  80 LLEKGADINVK 90
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 45-236 6.80e-19

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 85.40  E-value: 6.80e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  45 IYGRQLSL-RNLI-SQGWLVNIITADHVSPLHEACLGGHPSCVKILLKHGAQVNGVTTDWHTPLFNACVSGSQDCVNLLL 122
Cdd:PHA02874    9 IYSGDIEAiEKIIkNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLI 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 123 QHG--ASVQPESDLASpiheaarrghvECVDSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQ 199
Cdd:PHA02874   89 DNGvdTSILPIPCIEK-----------DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNiEDDNG 157

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1751290757 200 DSPLHAAARTASEELACLLMDFGADTQAKNAEGKRPV 236
Cdd:PHA02874  158 CYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPL 194
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 94-227 8.70e-07

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 49.69  E-value: 8.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  94 QVNGVTTDWHTPLFNACVSGS-QDCVNLLLQHGASVQPESDLaspIHeAARRGHVECVDSLIAYGGNIDHKISHLG---- 168
Cdd:TIGR00870  44 NINCPDRLGRSALFVAAIENEnLELTELLLNLSCRGAVGDTL---LH-AISLEYVDAVEAILLHLLAAFRKSGPLEland 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 169 ----------TPLYLACENQQRACVKKLLESGADVN---------QGKGQD------SPLHAAARTASEELACLLMDFGA 223
Cdd:TIGR00870 120 qytseftpgiTALHLAAHRQNYEIVKLLLERGASVParacgdffvKSQGVDsfyhgeSPLNAAACLGSPSIVALLSEDPA 199


                  ....
gi 1751290757 224 DTQA 227
Cdd:TIGR00870 200 DILT 203
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 68-96 5.54e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 5.54e-05
                           10        20
                   ....*....|....*....|....*....
gi 1751290757   68 DHVSPLHEACLGGHPSCVKILLKHGAQVN 96
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 102-236 1.38e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 42.69  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 102 WHTPLFNACVSGSQDCVN-LLLQHGASVQPESDLA-SPIHEAARRGHVECVDSLI-AYGGNIDHKIS---HLG-TPLYLA 174
Cdd:cd22192    17 SESPLLLAAKENDVQAIKkLLKCPSCDLFQRGALGeTALHVAALYDNLEAAVVLMeAAPELVNEPMTsdlYQGeTALHIA 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1751290757 175 CENQQRACVKKLLESGADVNQG--------KGQDS-------PLHAAARTASEELACLLMDFGADTQAKNAEGKRPV 236
Cdd:cd22192    97 VVNQNLNLVRELIARGADVVSPratgtffrPGPKNliyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
22-261 1.13e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 141.63  E-value: 1.13e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  22 IRLLSNPLMSDAVSDWSPMHEAAIYGRQLSLRNLISQGWLVNIITADHVSPLHEACLGGHPSCVKILLKHGAQVNGVTTD 101
Cdd:COG0666    40 LLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKD 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 102 WHTPLFNACVSGSQDCVNLLLQHGASV-QPESDLASPIHEAARRGHVECVDSLIAYGGNIDHKISHLGTPLYLACENQQR 180
Cdd:COG0666   120 GETPLHLAAYNGNLEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHL 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 181 ACVKKLLESGADVN-QGKGQDSPLHAAARTASEELACLLMDFGADTQAKNAEGKRPVELVPPDSPLARLFLEREGASLPK 259
Cdd:COG0666   200 EIVKLLLEAGADVNaKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLA 279


                  ..
gi 1751290757 260 PK 261
Cdd:COG0666   280 AA 281
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
36-234 2.89e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 132.77  E-value: 2.89e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  36 DWSPMHEAAIYGRQLSLRNLISQGWLVNIITADHVSPLHEACLGGHPSCVKILLKHGAQVNGVTTDWHTPLFNACVSGSQ 115
Cdd:COG0666    87 GNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 116 DCVNLLLQHGASV-QPESDLASPIHEAARRGHVECVDSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN 194
Cdd:COG0666   167 EIVKLLLEAGADVnARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLN 246

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1751290757 195 -QGKGQDSPLHAAARTASEELACLLMDFGADTQAKNAEGKR 234
Cdd:COG0666   247 aKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
21-238 5.82e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 124.30  E-value: 5.82e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  21 DIRLLSNPLMSDAVSDWSPMHEAAIYGRQLSLRNLISQGWLVNIITADHVSPLHEACLGGHPSCVKILLKHGAQVNGVTT 100
Cdd:COG0666     6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 101 DWHTPLFNACVSGSQDCVNLLLQHGASV-QPESDLASPIHEAARRGHVECVDSLIAYGGNIDHKISHLGTPLYLACENQQ 179
Cdd:COG0666    86 GGNTLLHAAARNGDLEIVKLLLEAGADVnARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGN 165

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 180 RACVKKLLESGADVN-QGKGQDSPLHAAARTASEELACLLMDFGADTQAKNAEGKRPVEL 238
Cdd:COG0666   166 LEIVKLLLEAGADVNaRDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
35-197 3.46e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 111.58  E-value: 3.46e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  35 SDWSPMHEAAIYGRQLSLRNLISQGWLVNIITADHVSPLHEACLGGHPSCVKILLKHGAQVNGVTTDWHTPLFNACVSGS 114
Cdd:COG0666   119 DGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGH 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 115 QDCVNLLLQHGASV-QPESDLASPIHEAARRGHVECVDSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADV 193
Cdd:COG0666   199 LEIVKLLLEAGADVnAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLL 278


                  ....
gi 1751290757 194 NQGK 197
Cdd:COG0666   279 AAAL 282
Ank_2 pfam12796
Ankyrin repeats (3 copies);
73-163 5.78e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 81.70  E-value: 5.78e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  73 LHEACLGGHPSCVKILLKHGAQVNGVTTDWHTPLFNACVSGSQDCVNLLLQHgASVQPESDLASPIHEAARRGHVECVDS 152
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|.
gi 1751290757 153 LIAYGGNIDHK 163
Cdd:pfam12796  80 LLEKGADINVK 90
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 45-236 6.80e-19

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 85.40  E-value: 6.80e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  45 IYGRQLSL-RNLI-SQGWLVNIITADHVSPLHEACLGGHPSCVKILLKHGAQVNGVTTDWHTPLFNACVSGSQDCVNLLL 122
Cdd:PHA02874    9 IYSGDIEAiEKIIkNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLI 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 123 QHG--ASVQPESDLASpiheaarrghvECVDSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQ 199
Cdd:PHA02874   89 DNGvdTSILPIPCIEK-----------DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNiEDDNG 157

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1751290757 200 DSPLHAAARTASEELACLLMDFGADTQAKNAEGKRPV 236
Cdd:PHA02874  158 CYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPL 194
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 85-239 1.70e-17

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 81.46  E-value: 1.70e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  85 VKILLKHGAQVNGVTTDW-HTPLFNACVSGSQDCVNLLLQHGASVQ-PESDLASPIHEAARRGHVECVDSLIAYGGNIDH 162
Cdd:PHA02878  150 TKLLLSYGADINMKDRHKgNTALHYATENKDQRLTELLLSYGANVNiPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 163 KISHLGTPLYLA---CENQQraCVKKLLESGADVNQGKG--QDSPLHAAARtaSEELACLLMDFGADTQAKNAEGKRPVE 237
Cdd:PHA02878  230 RDKCGNTPLHISvgyCKDYD--ILKLLLEHGVDVNAKSYilGLTALHSSIK--SERKLKLLLEYGADINSLNSYKLTPLS 305


                  ..
gi 1751290757 238 LV 239
Cdd:PHA02878  306 SA 307
Ank_2 pfam12796
Ankyrin repeats (3 copies);
40-128 2.75e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 74.77  E-value: 2.75e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  40 MHEAAIYGRQLSLRNLISQGWLVNIITADHVSPLHEACLGGHPSCVKILLKHgAQVNGVTTDWhTPLFNACVSGSQDCVN 119
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR-TALHYAARSGHLEIVK 78


                  ....*....
gi 1751290757 120 LLLQHGASV 128
Cdd:pfam12796  79 LLLEKGADI 87
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
37-171 6.49e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 78.46  E-value: 6.49e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  37 WSPMHEAAIYGRQLSLRNLISQGWLVNIITADHVSPLHEACLGGHPSCVKILLKHGAQVNGVTTDWHTPLFNACVSGSQD 116
Cdd:COG0666   154 NTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLE 233

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1751290757 117 CVNLLLQHGASVQPE-SDLASPIHEAARRGHVECVDSLIAYGGNIDHKISHLGTPL 171
Cdd:COG0666   234 IVKLLLEAGADLNAKdKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 38-236 2.54e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 78.18  E-value: 2.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  38 SPMHEAaIYGRQLS--LRNLISQGWLVNIITADHVSPLHEACLGGHPS-CVKILLKHGAQVNGVTTDWHTPLFNA-CVSG 113
Cdd:PHA02876  275 TPLHHA-SQAPSLSrlVPKLLERGADVNAKNIKGETPLYLMAKNGYDTeNIRTLIMLGADVNAADRLYITPLHQAsTLDR 353

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 114 SQDCVNLLLQHGASVQPESDL-ASPIHEAARRGHVECVDSLIAYGGNIDHKISHLGTPLYLA-CENQQRACVKKLLESGA 191
Cdd:PHA02876  354 NKDIVITLLELGANVNARDYCdKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGA 433

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1751290757 192 DVN-QGKGQDSPLHAAARTASE-ELACLLMDFGADTQAKNAEGKRPV 236
Cdd:PHA02876  434 NVNsKNKDLSTPLHYACKKNCKlDVIEMLLDNGADVNAINIQNQYPL 480
Ank_2 pfam12796
Ankyrin repeats (3 copies);
138-229 3.71e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.69  E-value: 3.71e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 138 IHEAARRGHVECVDSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESgADVNQGKGQDSPLHAAARTASEELACL 217
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|..
gi 1751290757 218 LMDFGADTQAKN 229
Cdd:pfam12796  80 LLEKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 51-239 2.16e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 72.01  E-value: 2.16e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  51 SLRNLISQGWLVNIITADHVSPLHEACLGGHPSCVKILLKHGAQVNGVTTDWHTPL--FNACVSGSQDCVN---LLLQHG 125
Cdd:PHA03100   17 NIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLhyLSNIKYNLTDVKEivkLLLEYG 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 126 ASVQPESDLA-SPIHEAA--RRGHVECVDSLIAYGGNIDHKISHLGTPL--YLACENQQRACVKKLLESGADVNQ----- 195
Cdd:PHA03100   97 ANVNAPDNNGiTPLLYAIskKSNSYSIVEYLLDNGANVNIKNSDGENLLhlYLESNKIDLKILKLLIDKGVDINAknrvn 176

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1751290757 196 ---GKGQD---------SPLHAAARTASEELACLLMDFGADTQAKNAEGKRPVELV 239
Cdd:PHA03100  177 yllSYGVPinikdvygfTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIA 232
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 43-193 1.42e-12

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 67.20  E-value: 1.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  43 AAIYGRQLSLRNLISQGWLVNIITADHVSPLHEACLGGHPSCVKILLKHGAQVNGVTTDWHTPLFNACVSGSQDCVNLLL 122
Cdd:PLN03192  532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY 611

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1751290757 123 QHGASVQPES--DLaspIHEAARRGHVECVDSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADV 193
Cdd:PLN03192  612 HFASISDPHAagDL---LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADV 681
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 17-194 2.75e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 65.78  E-value: 2.75e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  17 RDSPDIRLLsnpLMSDAVSDW------SPMHEAAIYGRQLSLRNLISQGWLVN-IITADHVSPLHEACLGGHPSCVKILL 89
Cdd:PHA02875   46 RDSEAIKLL---MKHGAIPDVkypdieSELHDAVEEGDVKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLLI 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  90 KHGAQVNGVTTDWHTPLFNACVSGSQDCVNLLLQHGASVQPESDLA-SPIHEAARRGHVECVDSLIAYGGNIDHkISHLG 168
Cdd:PHA02875  123 ARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGcTPLIIAMAKGDIAICKMLLDSGANIDY-FGKNG 201

                         170       180
                  ....*....|....*....|....*...
gi 1751290757 169 --TPLYLACENQQRACVKKLLESGADVN 194
Cdd:PHA02875  202 cvAALCYAIENNKIDIVRLFIKRGADCN 229
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 37-225 7.00e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 64.63  E-value: 7.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  37 WSPMHEAAIYGRQLSLRNLISQGWLVNIITADHVSPLHEACLGGHPSCVKILLKHGAQVNGVT-TDWHTPLFNACVSGSQ 115
Cdd:PHA02875   36 ISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFyKDGMTPLHLATILKKL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 116 DCVNLLLQHGASVQ-PESDLASPIHEAARRGHVECVDSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN 194
Cdd:PHA02875  116 DIMKLLIARGADPDiPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANID 195

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1751290757 195 Q-GKGQD-SPLHAAARTASEELACLLMDFGADT 225
Cdd:PHA02875  196 YfGKNGCvAALCYAIENNKIDIVRLFIKRGADC 228
PHA03095 PHA03095
ankyrin-like protein; Provisional
 72-236 2.88e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 60.04  E-value: 2.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  72 PLHeACLGG---HPSCVKILLKHGAQVNGVTTDWHTPLfnACVSGSQDC----VNLLLQHGASV-QPESDLASPIHEAAR 143
Cdd:PHA03095  120 PLH-VYLSGfniNPKVIRLLLRKGADVNALDLYGMTPL--AVLLKSRNAnvelLRLLIDAGADVyAVDDRFRSLLHHHLQ 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 144 --RGHVECVDSLIAYGGNIDHKISHLGTPL-YLACENQQRAC-VKKLLESGADVN--QGKGQdSPLHAAARTASEELACL 217
Cdd:PHA03095  197 sfKPRARIVRELIRAGCDPAATDMLGNTPLhSMATGSSCKRSlVLPLLIAGISINarNRYGQ-TPLHYAAVFNNPRACRR 275

                         170
                  ....*....|....*....
gi 1751290757 218 LMDFGADTQAKNAEGKRPV 236
Cdd:PHA03095  276 LIALGADINAVSSDGNTPL 294
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 55-167 3.69e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 59.68  E-value: 3.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  55 LISQGWLVNIITADHVSPLHEACLGGHP--SCVKILLKHGAQVN-----------GVTTDW-----HTPLFNACVSGSQD 116
Cdd:PHA03100  127 LLDNGANVNIKNSDGENLLHLYLESNKIdlKILKLLIDKGVDINaknrvnyllsyGVPINIkdvygFTPLHYAVYNNNPE 206

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1751290757 117 CVNLLLQHGASVQPESDLA-SPIHEAARRGHVECVDSLIAYGGNIDHKISHL 167
Cdd:PHA03100  207 FVKYLLDLGANPNLVNKYGdTPLHIAILNNNKEIFKLLLNNGPSIKTIIETL 258
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 39-236 4.59e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 59.51  E-value: 4.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  39 PMHEAaIYGRQLSL-RNLISQGWLVNIITADHVSPLHEACLGGHPSCVKILLKHGAQVNgvttdwhtpLFNACVSGSQDC 117
Cdd:PHA02878   40 PLHQA-VEARNLDVvKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCS---------VFYTLVAIKDAF 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 118 VN--------LLLQHGASVQpESDLASpIHEAARRGHVEC--VDSLIAYGGNIDHKISHLG-TPLYLACENQQRACVKKL 186
Cdd:PHA02878  110 NNrnveifkiILTNRYKNIQ-TIDLVY-IDKKSKDDIIEAeiTKLLLSYGADINMKDRHKGnTALHYATENKDQRLTELL 187

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1751290757 187 LESGADVNQ-GKGQDSPLHAAARTASEELACLLMDFGADTQAKNAEGKRPV 236
Cdd:PHA02878  188 LSYGANVNIpDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPL 238
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 40-252 1.15e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 58.08  E-value: 1.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  40 MHEAAIYGRQLSLRNLISQGWLVNIITADHVSPLHEACLGGHPSCVKILLKHGAQVNGVTTDWHTPLFNACVSGSQDCVN 119
Cdd:PHA02875    6 LCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 120 LLLQHGASVQP--ESDLASPIHEAARRGHVECVDSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGA--DVNQ 195
Cdd:PHA02875   86 ELLDLGKFADDvfYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKAclDIED 165

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1751290757 196 GKGQdSPLHAAARTASEELACLLMDFGADTqakNAEGKRP--------VELVPPDspLARLFLER 252
Cdd:PHA02875  166 CCGC-TPLIIAMAKGDIAICKMLLDSGANI---DYFGKNGcvaalcyaIENNKID--IVRLFIKR 224
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 30-183 5.78e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 56.04  E-value: 5.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  30 MSDAVSDWSPMHEAAIYGRQLSLRNLISQGWLVNIITADHVSPLHEACLGGHPSCVKILLKHGAQVNGVTTDWHTPLFNA 109
Cdd:PHA02878  162 MKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHIS 241

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1751290757 110 CVS-GSQDCVNLLLQHGASVQPESDLA--SPIHEAARRGHVecVDSLIAYGGNIDHKISHLGTPLYLACenQQRACV 183
Cdd:PHA02878  242 VGYcKDYDILKLLLEHGVDVNAKSYILglTALHSSIKSERK--LKLLLEYGADINSLNSYKLTPLSSAV--KQYLCI 314
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 86-239 2.25e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 54.68  E-value: 2.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  86 KILLKHGAQVNGVTTDWHTPLFNACVSGSQDCVNLLLQHGASVQPES-DLASPIHEAARRGHVECVDSLIAYGGNIDHKi 164
Cdd:PHA02876  162 EMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIAlDDLSVLECAVDSKNIDTIKAIIDNRSNINKN- 240

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1751290757 165 shlGTPLYLACENQQRACVKKLLESGADVNQ-GKGQDSPLHAAARTAS-EELACLLMDFGADTQAKNAEGKRPVELV 239
Cdd:PHA02876  241 ---DLSLLKAIRNEDLETSLLLYDAGFSVNSiDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKNIKGETPLYLM 314
Ank_4 pfam13637
Ankyrin repeats (many copies);
102-154 1.61e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.88  E-value: 1.61e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1751290757 102 WHTPLFNACVSGSQDCVNLLLQHGASV--QPESDLaSPIHEAARRGHVECVDSLI 154
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADInaVDGNGE-TALHFAASNGNVEVLKLLL 54
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 55-229 1.69e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 51.99  E-value: 1.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  55 LISQGWLVNIITADHVSPLHEACLGGHPSCVKILLKHGAQVNGVTTDWHTPLFNACVSGSQDCVNLLLQHGASVQpESDL 134
Cdd:PHA02876  164 LLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNIN-KNDL 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 135 AspIHEAARRGHVECvdSLIAY--GGNIDHKISHLGTPLYLACENQQRA-CVKKLLESGADVNQG--KGQdSPLHAAART 209
Cdd:PHA02876  243 S--LLKAIRNEDLET--SLLLYdaGFSVNSIDDCKNTPLHHASQAPSLSrLVPKLLERGADVNAKniKGE-TPLYLMAKN 317

                         170       180
                  ....*....|....*....|..
gi 1751290757 210 A--SEELACLLMdFGADTQAKN 229
Cdd:PHA02876  318 GydTENIRTLIM-LGADVNAAD 338
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 42-132 3.85e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 50.67  E-value: 3.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  42 EAAIYGRQLSLRNLISQGWLVNIITADHVSPLHEACLGGHPSCVKILLKHGAQVNGVTTDWHTPLFNACVSGSQDCVNLL 121
Cdd:PTZ00322   88 QLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167

                          90
                  ....*....|....*...
gi 1751290757 122 LQH-------GASVQPES 132
Cdd:PTZ00322  168 SRHsqchfelGANAKPDS 185
Ank_4 pfam13637
Ankyrin repeats (many copies);
37-89 4.03e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 45.73  E-value: 4.03e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1751290757  37 WSPMHEAAIYGRQLSLRNLISQGWLVNIITADHVSPLHEACLGGHPSCVKILL 89
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_2 pfam12796
Ankyrin repeats (3 copies);
37-96 4.36e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.03  E-value: 4.36e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  37 WSPMHEAAIYGRQLSLRNLISQgWLVNIITaDHVSPLHEACLGGHPSCVKILLKHGAQVN 96
Cdd:pfam12796  31 RTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGADIN 88
PHA03095 PHA03095
ankyrin-like protein; Provisional
 118-236 4.87e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.41  E-value: 4.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 118 VNLLLQHGASVQPESDLAS-PIHEAARRGHVEC---VDSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLL-ESGAD 192
Cdd:PHA03095   30 VRRLLAAGADVNFRGEYGKtPLHLYLHYSSEKVkdiVRLLLEAGADVNAPERCGFTPLHLYLYNATTLDVIKLLiKAGAD 109

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1751290757 193 VN-QGKGQDSPLHAAARTAS--EELACLLMDFGADTQAKNAEGKRPV 236
Cdd:PHA03095  110 VNaKDKVGRTPLHVYLSGFNinPKVIRLLLRKGADVNALDLYGMTPL 156
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 94-227 8.70e-07

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 49.69  E-value: 8.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  94 QVNGVTTDWHTPLFNACVSGS-QDCVNLLLQHGASVQPESDLaspIHeAARRGHVECVDSLIAYGGNIDHKISHLG---- 168
Cdd:TIGR00870  44 NINCPDRLGRSALFVAAIENEnLELTELLLNLSCRGAVGDTL---LH-AISLEYVDAVEAILLHLLAAFRKSGPLEland 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 169 ----------TPLYLACENQQRACVKKLLESGADVN---------QGKGQD------SPLHAAARTASEELACLLMDFGA 223
Cdd:TIGR00870 120 qytseftpgiTALHLAAHRQNYEIVKLLLERGASVParacgdffvKSQGVDsfyhgeSPLNAAACLGSPSIVALLSEDPA 199


                  ....
gi 1751290757 224 DTQA 227
Cdd:TIGR00870 200 DILT 203
Ank_4 pfam13637
Ankyrin repeats (many copies);
69-122 1.02e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.96  E-value: 1.02e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1751290757  69 HVSPLHEACLGGHPSCVKILLKHGAQVNGVTTDWHTPLFNACVSGSQDCVNLLL 122
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
136-187 1.33e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.57  E-value: 1.33e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1751290757 136 SPIHEAARRGHVECVDSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLL 187
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 44-129 2.66e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 48.14  E-value: 2.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  44 AIYGRQ--LSLRNLISQGWLVNIITADHVSPLHEACLGG-HPSCVKILLKHGAQVNGVTTDWHTPLFNACvsGSQDCVNL 120
Cdd:PHA02876  415 ALCGTNpyMSVKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIAL--EYHGIVNI 492


                  ....*....
gi 1751290757 121 LLQHGASVQ 129
Cdd:PHA02876  493 LLHYGAELR 501
PHA03095 PHA03095
ankyrin-like protein; Provisional
 41-257 3.12e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 47.71  E-value: 3.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  41 HEAAIYGRQLS--------LRNLISQGWLVNIITADHVSPLHEACLGGHPSCVKI---LLKHGAQVNGVTTDWHTPLF-- 107
Cdd:PHA03095   11 MEAALYDYLLNasnvtveeVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIvrlLLEAGADVNAPERCGFTPLHly 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 108 --NACVsgsQDCVNLLLQHGASVQPESDLA-SPIHEAAR--RGHVECVDSLIAYGGNIDHKISHLGTPL--YLACENQQR 180
Cdd:PHA03095   91 lyNATT---LDVIKLLIKAGADVNAKDKVGrTPLHVYLSgfNINPKVIRLLLRKGADVNALDLYGMTPLavLLKSRNANV 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 181 ACVKKLLESGADV----NQGkgqDSPLHAAARTASEELACL--LMDFGADTQAKNAEGKRPVELVPPDSPLARL----FL 250
Cdd:PHA03095  168 ELLRLLIDAGADVyavdDRF---RSLLHHHLQSFKPRARIVreLIRAGCDPAATDMLGNTPLHSMATGSSCKRSlvlpLL 244


                  ....*..
gi 1751290757 251 ErEGASL 257
Cdd:PHA03095  245 I-AGISI 250
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 36-128 8.93e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 46.60  E-value: 8.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  36 DWSPMHEAAIYGRQLSLRNLISQGWLVNIITADHVSPLHEACLGGHP-SCVKILLKHGAQVNGVTTDWHTPLFNACVSGS 114
Cdd:PHA02876  375 DKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPyMSVKTLIDRGANVNSKNKDLSTPLHYACKKNC 454

                          90
                  ....*....|....*
gi 1751290757 115 Q-DCVNLLLQHGASV 128
Cdd:PHA02876  455 KlDVIEMLLDNGADV 469
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 68-96 5.54e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 5.54e-05
                           10        20
                   ....*....|....*....|....*....
gi 1751290757   68 DHVSPLHEACLGGHPSCVKILLKHGAQVN 96
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
PHA03095 PHA03095
ankyrin-like protein; Provisional
 16-158 1.32e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 42.70  E-value: 1.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  16 PRDSPDI-----RLLSNPLMSDaVSDWSPMHEAAIYG--RQLSLRNLISQGWLVNIITADHVSPLHEA-CLGGHPSCVKi 87
Cdd:PHA03095  198 FKPRARIvreliRAGCDPAATD-MLGNTPLHSMATGSscKRSLVLPLLIAGISINARNRYGQTPLHYAaVFNNPRACRR- 275

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1751290757  88 LLKHGAQVNGVTTDWHTPLFNACVSGSQDCVNLLLqhgaSVQPESDL-ASPIHEAARRGHV-------ECVDSLIAYGG 158
Cdd:PHA03095  276 LIALGADINAVSSDGNTPLSLMVRNNNGRAVRAAL----AKNPSAETvAATLNTASVAGGDipsdatrLCVAKVVLRGA 350
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 102-236 1.38e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 42.69  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 102 WHTPLFNACVSGSQDCVN-LLLQHGASVQPESDLA-SPIHEAARRGHVECVDSLI-AYGGNIDHKIS---HLG-TPLYLA 174
Cdd:cd22192    17 SESPLLLAAKENDVQAIKkLLKCPSCDLFQRGALGeTALHVAALYDNLEAAVVLMeAAPELVNEPMTsdlYQGeTALHIA 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1751290757 175 CENQQRACVKKLLESGADVNQG--------KGQDS-------PLHAAARTASEELACLLMDFGADTQAKNAEGKRPV 236
Cdd:cd22192    97 VVNQNLNLVRELIARGADVVSPratgtffrPGPKNliyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 38-128 2.89e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 41.87  E-value: 2.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  38 SPMHEAAIYGRQLSLRNLISQGWLVNIITADHVSPLHEACLggHPSCVKILLKHGAQVNGVTTDWHTPLFNA----Cvsg 113
Cdd:PHA02874  192 SPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII--HNRSAIELLINNASINDQDIDGSTPLHHAinppC--- 266

                          90
                  ....*....|....*
gi 1751290757 114 SQDCVNLLLQHGASV 128
Cdd:PHA02874  267 DIDIIDILLYHKADI 281
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 104-184 3.01e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 41.51  E-value: 3.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 104 TPLFNACVSGSQDCVNLLLQHGASVQPESDLA--SPIHEAARRGHVECVDSLIAYGGNIDHKISHLGTPLYLA---CENQ 178
Cdd:PHA02884   72 NPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAkiTPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIELAlmiCNNF 151


                  ....*.
gi 1751290757 179 QRACVK 184
Cdd:PHA02884  152 LAFMIC 157
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 169-194 4.05e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 4.05e-04
                           10        20
                   ....*....|....*....|....*.
gi 1751290757  169 TPLYLACENQQRACVKKLLESGADVN 194
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 78-231 4.59e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 41.40  E-value: 4.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  78 LGGHPSCVKILLKHGAQVNGVTTDwhTPLFNACV---SGSQDCVNLLLQhgasVQPESDLASPIHEAarrghvECVDSLi 154
Cdd:cd21882     4 LLGLLECLRWYLTDSAYQRGATGK--TCLHKAALnlnDGVNEAIMLLLE----AAPDSGNPKELVNA------PCTDEF- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 155 aYGGNidhkishlgTPLYLACENQQRACVKKLLESGADV-----------NQGKG---QDSPLHAAARTASEELACLLMD 220
Cdd:cd21882    71 -YQGQ---------TALHIAIENRNLNLVRLLVENGADVsaratgrffrkSPGNLfyfGELPLSLAACTNQEEIVRLLLE 140

                         170
                  ....*....|.
gi 1751290757 221 FGADTQAKNAE 231
Cdd:cd21882   141 NGAQPAALEAQ 151
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 153-260 5.17e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.04  E-value: 5.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 153 LIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLHAAARTASEELACLLM-------DFGAD 224
Cdd:PTZ00322  101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTlLDKDGKTPLELAEENGFREVVQLLSrhsqchfELGAN 180

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1751290757 225 TQAKNAEGKRPVELVPPDSPLARLFleregASLPKP 260
Cdd:PTZ00322  181 AKPDSFTGKPPSLEDSPISSHHPDF-----SAVPQP 211
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 34-106 5.84e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 40.35  E-value: 5.84e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1751290757  34 VSDWSPMHEAAIYGRQLSLRNLISQGWLVNIITADHV-SPLHEACLGGHPSCVKILLKHGAQVNGVTTDWHTPL 106
Cdd:PHA02884   68 NSKTNPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAKiTPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPI 141
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 40-141 6.84e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 40.72  E-value: 6.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  40 MHEAAIYGRQLSLRNLISQGWLVNIITADHVSPLHEACLGGHPSCVKILLKHGAQVNGVTTDWHTPLFNACVSGSQDCVN 119
Cdd:PHA02874  128 LHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIK 207

                          90       100
                  ....*....|....*....|...
gi 1751290757 120 LLLQHGASVQPESDLA-SPIHEA 141
Cdd:PHA02874  208 LLIDHGNHIMNKCKNGfTPLHNA 230
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 183-238 7.66e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.65  E-value: 7.66e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1751290757 183 VKKLLESGADVN-QGKGQDSPLHAAARTASEELACLLMDFGADTQAKNAEGKRPVEL 238
Cdd:PTZ00322   98 ARILLTGGADPNcRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLEL 154
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 71-96 9.98e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.73  E-value: 9.98e-04
                          10        20
                  ....*....|....*....|....*..
gi 1751290757  71 SPLHEACL-GGHPSCVKILLKHGAQVN 96
Cdd:pfam00023   4 TPLHLAAGrRGNLEIVKLLLSKGADVN 30
Ank_4 pfam13637
Ankyrin repeats (many copies);
169-218 1.05e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.48  E-value: 1.05e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1751290757 169 TPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLHAAARTASEELACLL 218
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINaVDGNGETALHFAASNGNVEVLKLL 53
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 68-96 1.46e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.31  E-value: 1.46e-03
                          10        20
                  ....*....|....*....|....*....
gi 1751290757  68 DHVSPLHEACLGGHPSCVKILLKHGAQVN 96
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
PHA02798 PHA02798
ankyrin-like protein; Provisional
 85-195 1.62e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 39.43  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  85 VKILLKHGAQVNGVTTDWHTPLfnaCVSGSQ--------DCVNLLLQHGASV-QPESDLASPIHEAARRGHV---ECVDS 152
Cdd:PHA02798   54 VKLFINLGANVNGLDNEYSTPL---CTILSNikdykhmlDIVKILIENGADInKKNSDGETPLYCLLSNGYInnlEILLF 130

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1751290757 153 LIAYGGNI--DHKISHLGTPLYLACENQ-QRACVKKLLESGADVNQ 195
Cdd:PHA02798  131 MIENGADTtlLDKDGFTMLQVYLQSNHHiDIEIIKLLLEKGVDINT 176
Ank_5 pfam13857
Ankyrin repeats (many copies);
60-106 1.63e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.79  E-value: 1.63e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1751290757  60 WLVNIITADHVSPLHEACLGGHPSCVKILLKHGAQVNGVTTDWHTPL 106
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 136-161 2.65e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 2.65e-03
                           10        20
                   ....*....|....*....|....*.
gi 1751290757  136 SPIHEAARRGHVECVDSLIAYGGNID 161
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
PHA02946 PHA02946
ankyin-like protein; Provisional
 52-239 3.12e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 38.50  E-value: 3.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757  52 LRNLISQGWLVNIITADHVSPLHEACLGGHPSCVKILLKHGAQVNGVTTDWHTPLFNacVSGSQDCVnlllqhgasvqpe 131
Cdd:PHA02946   55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYY--LSGTDDEV------------- 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751290757 132 sdlaspiheaarrghVECVDSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGAD---VNQGKGQDSPLHAAAR 208
Cdd:PHA02946  120 ---------------IERINLLVQYGAKINNSVDEEGCGPLLACTDPSERVFKKIMSIGFEariVDKFGKNHIHRHLMSD 184

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1751290757 209 TASEELACLLMDFGADTQAKNAEGKRPVELV 239
Cdd:PHA02946  185 NPKASTISWMMKLGISPSKPDHDGNTPLHIV 215
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 169-194 6.69e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 33.38  E-value: 6.69e-03
                          10        20
                  ....*....|....*....|....*.
gi 1751290757 169 TPLYLACENQQRACVKKLLESGADVN 194
Cdd:pfam13606   4 TPLHLAARNGRLEIVKLLLENGADIN 29
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 101-128 7.02e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 33.33  E-value: 7.02e-03
                           10        20
                   ....*....|....*....|....*...
gi 1751290757  101 DWHTPLFNACVSGSQDCVNLLLQHGASV 128
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH