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Conserved domains on  [gi|1743192702|ref|XP_030658268|]
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autophagy-related protein 9A isoform X2 [Nomascus leucogenys]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ATG9 pfam04109
Autophagy protein ATG9; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 1-464 0e+00

Autophagy protein ATG9; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg9 plays a direct role in the formation of the cytoplasm to vacuole targeting and autophagic vesicles, and it is the sole transmembrane protein in the autophagosome-forming machinery. It colocalizes with Atg2 at the expanding edge of the isolation membrane where Atg2 receives phospholipids from the endoplasmic reticulum (ER). Atg9 is a lipid scramblase that translocates phospholipids between outer and inner leaflets of liposomes. Phospholipids delivered by Atg2 are translocated from the cytoplasmic to the luminal leaflet by Atg9, driving autophagosomal membrane expansion.


:

Pssm-ID: 461177  Cd Length: 478  Bit Score: 663.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743192702   1 MLIGEIFELMQFLFVVAFTTFLVSCVDYDILFAnkmvnhslhptePVKVTLPDAFLPaqVCSARIqeNGSLITILVIAGV 80
Cdd:pfam04109  28 ILLSRVLELLTLAFVVGFSTFLLLCVDYSKLFN------------PDSVTLSDVIVP--QCTSKI--SGFTKLLLWLFSI 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743192702  81 FWIHRLIKFIYNICCYWEIHSFYLHALRIPMSALPYCTWQEVQARIVQTQKEHQICIHKRELTELDIYHRILRFQNYMVA 160
Cdd:pfam04109  92 YWVLKLLQFFLDLRRLWEIRNFYNYLLNIPDSDLQTISWQEVVERIMALQDENPLTAHKVRLDAHDIANRIMRKENYLIA 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743192702 161 LVNKSLLPLRFRLPGLGEAVFFTRGLKYNFELILFWGpgsLFLNEWSLKAEYKRGGQRLELAQRLSNRILWIGIANFLLC 240
Cdd:pfam04109 172 LFNKDILDLTLPIPFLGNRQFLTKTLEWNLNLCLFDF---VFDENGQIRPEFLKDSNRKELAEELRKRFLFAGLLNLLLA 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743192702 241 PLILIWQILYAFFSYAEVLKREPGALGARCWSLYGRCYLRHFNELEHELQSRLNRGYKPASKYMNCFLSPLLTLLAKNGA 320
Cdd:pfam04109 249 PFIVIYFLLYYFFRYFEEYKKNPGSLGSRRWSPLARWKFREFNELPHLFQARLNRSYPPASKYLNQFPSPKTAIIAKFVA 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743192702 321 FFAGSILAVLIALTIYDEDVL------AVEHVLTTVTLLGVTVTVCRSFIPDQHMVFCPEQLLRVILAHIHYMPDHWQGN 394
Cdd:pfam04109 329 FVAGSFAAVLVLLTLLDPELFlnfeitPGRTVLFYITVFGTIWAVARGMIPDENLVFDPEQLLREVIQHTHYLPDEWKGK 408

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743192702 395 AHRSQTRDEFAQLFQYKAVFILEELLSPIVTPLILIFCLRPRALEIIDFFRNFTVEVVGVGDTCSFAQMD 464
Cdd:pfam04109 409 LHTDEVRAEFSELFQLKIVIFLEELLSIILTPFILWFSLPKCSDEIIDFFREFTVHVDGLGYVCSFAVFD 478
KLF9_13_N-like super family cl41730
Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like ...
 666-772 4.61e-05

Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF9, KLF13, KLF14, KLF16, and similar proteins.


The actual alignment was detected with superfamily member cd21576:

Pssm-ID: 425361 [Multi-domain]  Cd Length: 195  Bit Score: 45.20  E-value: 4.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743192702 666 RHVWHRRESDESG---------ESAPDEG---GEGARAPQSIPR-------SASYPCAAPRPGAPETTA-LHGGFQRRYG 725
Cdd:cd21576    21 GAVLHRRAPDPEGaggaagsevGAAPPESalpGPGPPGPAWVPPllqvpapSPGAGGAAPHLLAASVLAdLRGGAGEGSR 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1743192702 726 GitDPGTVPRAPSHFSRlplggwAEDGQSASRHPEPVPEEGsEDELP 772
Cdd:cd21576   101 E--DSGEAPRASSGSSD------PARGSSPTLGSEPAPASG-EDAVS 138
 
Name Accession Description Interval E-value
ATG9 pfam04109
Autophagy protein ATG9; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 1-464 0e+00

Autophagy protein ATG9; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg9 plays a direct role in the formation of the cytoplasm to vacuole targeting and autophagic vesicles, and it is the sole transmembrane protein in the autophagosome-forming machinery. It colocalizes with Atg2 at the expanding edge of the isolation membrane where Atg2 receives phospholipids from the endoplasmic reticulum (ER). Atg9 is a lipid scramblase that translocates phospholipids between outer and inner leaflets of liposomes. Phospholipids delivered by Atg2 are translocated from the cytoplasmic to the luminal leaflet by Atg9, driving autophagosomal membrane expansion.


Pssm-ID: 461177  Cd Length: 478  Bit Score: 663.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743192702   1 MLIGEIFELMQFLFVVAFTTFLVSCVDYDILFAnkmvnhslhptePVKVTLPDAFLPaqVCSARIqeNGSLITILVIAGV 80
Cdd:pfam04109  28 ILLSRVLELLTLAFVVGFSTFLLLCVDYSKLFN------------PDSVTLSDVIVP--QCTSKI--SGFTKLLLWLFSI 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743192702  81 FWIHRLIKFIYNICCYWEIHSFYLHALRIPMSALPYCTWQEVQARIVQTQKEHQICIHKRELTELDIYHRILRFQNYMVA 160
Cdd:pfam04109  92 YWVLKLLQFFLDLRRLWEIRNFYNYLLNIPDSDLQTISWQEVVERIMALQDENPLTAHKVRLDAHDIANRIMRKENYLIA 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743192702 161 LVNKSLLPLRFRLPGLGEAVFFTRGLKYNFELILFWGpgsLFLNEWSLKAEYKRGGQRLELAQRLSNRILWIGIANFLLC 240
Cdd:pfam04109 172 LFNKDILDLTLPIPFLGNRQFLTKTLEWNLNLCLFDF---VFDENGQIRPEFLKDSNRKELAEELRKRFLFAGLLNLLLA 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743192702 241 PLILIWQILYAFFSYAEVLKREPGALGARCWSLYGRCYLRHFNELEHELQSRLNRGYKPASKYMNCFLSPLLTLLAKNGA 320
Cdd:pfam04109 249 PFIVIYFLLYYFFRYFEEYKKNPGSLGSRRWSPLARWKFREFNELPHLFQARLNRSYPPASKYLNQFPSPKTAIIAKFVA 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743192702 321 FFAGSILAVLIALTIYDEDVL------AVEHVLTTVTLLGVTVTVCRSFIPDQHMVFCPEQLLRVILAHIHYMPDHWQGN 394
Cdd:pfam04109 329 FVAGSFAAVLVLLTLLDPELFlnfeitPGRTVLFYITVFGTIWAVARGMIPDENLVFDPEQLLREVIQHTHYLPDEWKGK 408

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743192702 395 AHRSQTRDEFAQLFQYKAVFILEELLSPIVTPLILIFCLRPRALEIIDFFRNFTVEVVGVGDTCSFAQMD 464
Cdd:pfam04109 409 LHTDEVRAEFSELFQLKIVIFLEELLSIILTPFILWFSLPKCSDEIIDFFREFTVHVDGLGYVCSFAVFD 478
KLF14_N cd21576
N-terminal domain of Kruppel-like factor 14; Kruppel-like factor 14 (KLF14; also known as ...
 666-772 4.61e-05

N-terminal domain of Kruppel-like factor 14; Kruppel-like factor 14 (KLF14; also known as Krueppel-like factor 14 or basic transcription element-binding protein 5/BTEB5) is a protein that in humans is encoded by the KLF14 gene. KLF14 regulates the transcription of various genes, including TGFbetaRII (the type II receptor for TGFbeta). KLF14 is expressed in many tissues, lacks introns, and is subject to parent-specific expression. It also appears to be a master regulator of gene expression in adipose tissue. KLF14 is associated with coronary artery disease, hypercholesterolemia, and type 2 diabetes. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF14 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF14.


Pssm-ID: 409238 [Multi-domain]  Cd Length: 195  Bit Score: 45.20  E-value: 4.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743192702 666 RHVWHRRESDESG---------ESAPDEG---GEGARAPQSIPR-------SASYPCAAPRPGAPETTA-LHGGFQRRYG 725
Cdd:cd21576    21 GAVLHRRAPDPEGaggaagsevGAAPPESalpGPGPPGPAWVPPllqvpapSPGAGGAAPHLLAASVLAdLRGGAGEGSR 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1743192702 726 GitDPGTVPRAPSHFSRlplggwAEDGQSASRHPEPVPEEGsEDELP 772
Cdd:cd21576   101 E--DSGEAPRASSGSSD------PARGSSPTLGSEPAPASG-EDAVS 138
 
Name Accession Description Interval E-value
ATG9 pfam04109
Autophagy protein ATG9; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 1-464 0e+00

Autophagy protein ATG9; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg9 plays a direct role in the formation of the cytoplasm to vacuole targeting and autophagic vesicles, and it is the sole transmembrane protein in the autophagosome-forming machinery. It colocalizes with Atg2 at the expanding edge of the isolation membrane where Atg2 receives phospholipids from the endoplasmic reticulum (ER). Atg9 is a lipid scramblase that translocates phospholipids between outer and inner leaflets of liposomes. Phospholipids delivered by Atg2 are translocated from the cytoplasmic to the luminal leaflet by Atg9, driving autophagosomal membrane expansion.


Pssm-ID: 461177  Cd Length: 478  Bit Score: 663.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743192702   1 MLIGEIFELMQFLFVVAFTTFLVSCVDYDILFAnkmvnhslhptePVKVTLPDAFLPaqVCSARIqeNGSLITILVIAGV 80
Cdd:pfam04109  28 ILLSRVLELLTLAFVVGFSTFLLLCVDYSKLFN------------PDSVTLSDVIVP--QCTSKI--SGFTKLLLWLFSI 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743192702  81 FWIHRLIKFIYNICCYWEIHSFYLHALRIPMSALPYCTWQEVQARIVQTQKEHQICIHKRELTELDIYHRILRFQNYMVA 160
Cdd:pfam04109  92 YWVLKLLQFFLDLRRLWEIRNFYNYLLNIPDSDLQTISWQEVVERIMALQDENPLTAHKVRLDAHDIANRIMRKENYLIA 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743192702 161 LVNKSLLPLRFRLPGLGEAVFFTRGLKYNFELILFWGpgsLFLNEWSLKAEYKRGGQRLELAQRLSNRILWIGIANFLLC 240
Cdd:pfam04109 172 LFNKDILDLTLPIPFLGNRQFLTKTLEWNLNLCLFDF---VFDENGQIRPEFLKDSNRKELAEELRKRFLFAGLLNLLLA 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743192702 241 PLILIWQILYAFFSYAEVLKREPGALGARCWSLYGRCYLRHFNELEHELQSRLNRGYKPASKYMNCFLSPLLTLLAKNGA 320
Cdd:pfam04109 249 PFIVIYFLLYYFFRYFEEYKKNPGSLGSRRWSPLARWKFREFNELPHLFQARLNRSYPPASKYLNQFPSPKTAIIAKFVA 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743192702 321 FFAGSILAVLIALTIYDEDVL------AVEHVLTTVTLLGVTVTVCRSFIPDQHMVFCPEQLLRVILAHIHYMPDHWQGN 394
Cdd:pfam04109 329 FVAGSFAAVLVLLTLLDPELFlnfeitPGRTVLFYITVFGTIWAVARGMIPDENLVFDPEQLLREVIQHTHYLPDEWKGK 408

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743192702 395 AHRSQTRDEFAQLFQYKAVFILEELLSPIVTPLILIFCLRPRALEIIDFFRNFTVEVVGVGDTCSFAQMD 464
Cdd:pfam04109 409 LHTDEVRAEFSELFQLKIVIFLEELLSIILTPFILWFSLPKCSDEIIDFFREFTVHVDGLGYVCSFAVFD 478
KLF14_N cd21576
N-terminal domain of Kruppel-like factor 14; Kruppel-like factor 14 (KLF14; also known as ...
 666-772 4.61e-05

N-terminal domain of Kruppel-like factor 14; Kruppel-like factor 14 (KLF14; also known as Krueppel-like factor 14 or basic transcription element-binding protein 5/BTEB5) is a protein that in humans is encoded by the KLF14 gene. KLF14 regulates the transcription of various genes, including TGFbetaRII (the type II receptor for TGFbeta). KLF14 is expressed in many tissues, lacks introns, and is subject to parent-specific expression. It also appears to be a master regulator of gene expression in adipose tissue. KLF14 is associated with coronary artery disease, hypercholesterolemia, and type 2 diabetes. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF14 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF14.


Pssm-ID: 409238 [Multi-domain]  Cd Length: 195  Bit Score: 45.20  E-value: 4.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743192702 666 RHVWHRRESDESG---------ESAPDEG---GEGARAPQSIPR-------SASYPCAAPRPGAPETTA-LHGGFQRRYG 725
Cdd:cd21576    21 GAVLHRRAPDPEGaggaagsevGAAPPESalpGPGPPGPAWVPPllqvpapSPGAGGAAPHLLAASVLAdLRGGAGEGSR 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1743192702 726 GitDPGTVPRAPSHFSRlplggwAEDGQSASRHPEPVPEEGsEDELP 772
Cdd:cd21576   101 E--DSGEAPRASSGSSD------PARGSSPTLGSEPAPASG-EDAVS 138
Saf_2TM pfam18303
SAVED-fused 2TM effector domain; Predicted pore-forming effector domain directly fused to ...
 179-262 1.04e-03

SAVED-fused 2TM effector domain; Predicted pore-forming effector domain directly fused to predicted SAVED sensor domain. Binding of a ligand via the SAVED sensor is predicted to activate the Saf-2TM and initiate a cell suicide response. Component of a class of conflict systems reliant on the production of second messenger nucleotide or nucleotide derivative.


Pssm-ID: 408111  Cd Length: 152  Bit Score: 40.43  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743192702 179 AVFFTRglKYNFELILFWGPGSLFLN----EWSLKAEYKRGGQRLELAQRLSNRILWIGIANFLLCPLILIWQILYAFFS 254
Cdd:pfam18303  12 IDWFFR--KRSAGMRLFTGGVALLLAgfggNWALKILFPDAGNSVEASFGSAEIPDWILAIILFIGSLLIIVGAVWAWQR 89


                  ....*...
gi 1743192702 255 YAEVLKRE 262
Cdd:pfam18303  90 YVNEQKRQ 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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