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Conserved domains on  [gi|1720419060|ref|XP_030111513|]
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WD repeat-containing protein 54 isoform X1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1903264)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl43672
WD40 repeat [General function prediction only];
168-315 4.90e-07

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.07  E-value: 4.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419060 168 VGTCSGRVLVFDIPAKgpniVLSEELAGHQTPITDIATeRAQGQDgvadMVTADDSGVLCVWrSGPEFTLLTRIPGFGVP 247
Cdd:COG2319   263 SGSADGTVRLWDLATG----ELLRTLTGHSGGVNSVAF-SPDGKL----LASGSDDGTVRLW-DLATGKLLRTLTGHTGA 332

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419060 248 CPSVQL--WQGIVAAGYGNGQVRLYDASTGALHVQISAHARTISALDLAPEVGKLLSAAEDTFVHIWKLN 315
Cdd:COG2319   333 VRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
168-315 4.90e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.07  E-value: 4.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419060 168 VGTCSGRVLVFDIPAKgpniVLSEELAGHQTPITDIATeRAQGQDgvadMVTADDSGVLCVWrSGPEFTLLTRIPGFGVP 247
Cdd:COG2319   263 SGSADGTVRLWDLATG----ELLRTLTGHSGGVNSVAF-SPDGKL----LASGSDDGTVRLW-DLATGKLLRTLTGHTGA 332

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419060 248 CPSVQL--WQGIVAAGYGNGQVRLYDASTGALHVQISAHARTISALDLAPEVGKLLSAAEDTFVHIWKLN 315
Cdd:COG2319   333 VRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 164-313 5.01e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 5.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419060 164 HFICVGTCSGRVLVFDIPakgpNIVLSEELAGHQTPITDIAteraQGQDGvADMVTADDSGVLCVWRSgPEFTLLTRIPG 243
Cdd:cd00200   148 TFVASSSQDGTIKLWDLR----TGKCVATLTGHTGEVNSVA----FSPDG-EKLLSSSSDGTIKLWDL-STGKCLGTLRG 217

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720419060 244 FGVPCPSVQL--WQGIVAAGYGNGQVRLYDASTGALHVQISAHARTISALDLAPEVGKLLSAAEDTFVHIWK 313
Cdd:cd00200   218 HENGVNSVAFspDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
168-315 4.90e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.07  E-value: 4.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419060 168 VGTCSGRVLVFDIPAKgpniVLSEELAGHQTPITDIATeRAQGQDgvadMVTADDSGVLCVWrSGPEFTLLTRIPGFGVP 247
Cdd:COG2319   263 SGSADGTVRLWDLATG----ELLRTLTGHSGGVNSVAF-SPDGKL----LASGSDDGTVRLW-DLATGKLLRTLTGHTGA 332

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419060 248 CPSVQL--WQGIVAAGYGNGQVRLYDASTGALHVQISAHARTISALDLAPEVGKLLSAAEDTFVHIWKLN 315
Cdd:COG2319   333 VRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 164-313 5.01e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 5.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419060 164 HFICVGTCSGRVLVFDIPakgpNIVLSEELAGHQTPITDIAteraQGQDGvADMVTADDSGVLCVWRSgPEFTLLTRIPG 243
Cdd:cd00200   148 TFVASSSQDGTIKLWDLR----TGKCVATLTGHTGEVNSVA----FSPDG-EKLLSSSSDGTIKLWDL-STGKCLGTLRG 217

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720419060 244 FGVPCPSVQL--WQGIVAAGYGNGQVRLYDASTGALHVQISAHARTISALDLAPEVGKLLSAAEDTFVHIWK 313
Cdd:cd00200   218 HENGVNSVAFspDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
188-314 1.23e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.83  E-value: 1.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419060 188 VLSEELAGHQTPITDIATERAQGQDGVADMVTADDSGVLCVWRSGPEFTLLTRIPGFGVPCPSVQLWQGIVAAGYGNGQV 267
Cdd:COG2319    23 AALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTV 102

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1720419060 268 RLYDASTGALHVQISAHARTISALDLAPEVGKLLSAAEDTFVHIWKL 314
Cdd:COG2319   103 RLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 132-315 1.31e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.17  E-value: 1.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419060 132 SDGSVMVyWHaLDSGDASSVQ---AMFARGIAASVHFICVGTCS--GRVLVFDIPAKgpniVLSEELAGHQTPITDIAte 206
Cdd:cd00200    29 GDGTIKV-WD-LETGELLRTLkghTGPVRDVAASADGTYLASGSsdKTIRLWDLETG----ECVRTLTGHTSYVSSVA-- 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419060 207 rAQGQDGVAdmVTADDSGVLCVWrSGPEFTLLTRIPGF--GVPCPSVQLWQGIVAAGYGNGQVRLYDASTGALHVQISAH 284
Cdd:cd00200   101 -FSPDGRIL--SSSSRDKTIKVW-DVETGKCLTTLRGHtdWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGH 176

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1720419060 285 ARTISALDLAPEVGKLLSAAEDTFVHIWKLN 315
Cdd:cd00200   177 TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS 207
WD40 COG2319
WD40 repeat [General function prediction only];
192-315 3.55e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.29  E-value: 3.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419060 192 ELAGHQTPITDIATeRAQGQDgvadMVTADDSGVLCVWRSgPEFTLLTRIPGFGVPCPSVQLWQG--IVAAGYGNGQVRL 269
Cdd:COG2319   157 TLTGHSGAVTSVAF-SPDGKL----LASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDgkLLASGSADGTVRL 230

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1720419060 270 YDASTGALHVQISAHARTISALDLAPEvGKLL-SAAEDTFVHIWKLN 315
Cdd:COG2319   231 WDLATGKLLRTLTGHSGSVRSVAFSPD-GRLLaSGSADGTVRLWDLA 276
WD40 COG2319
WD40 repeat [General function prediction only];
173-315 2.78e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 2.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419060 173 GRVLVFDIPAKGpnivLSEELAGHQTPITDIATeraqGQDG--VAdmvTADDSGVLCVW--RSGPEFTLLTRiPGFGVPC 248
Cdd:COG2319   184 GTVRLWDLATGK----LLRTLTGHTGAVRSVAF----SPDGklLA---SGSADGTVRLWdlATGKLLRTLTG-HSGSVRS 251

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720419060 249 PSVQLWQGIVAAGYGNGQVRLYDASTGALHVQISAHARTISALDLAPEvGKLL-SAAEDTFVHIWKLN 315
Cdd:COG2319   252 VAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD-GKLLaSGSDDGTVRLWDLA 318
WD40 COG2319
WD40 repeat [General function prediction only];
257-314 9.73e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.05  E-value: 9.73e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720419060 257 IVAAGYGNGQVRLYDASTGALHVQISAHARTISALDLAPEvGKLL-SAAEDTFVHIWKL 314
Cdd:COG2319   134 TLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPD-GKLLaSGSDDGTVRLWDL 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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