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Conserved domains on  [gi|1720413842|ref|XP_030110434|]
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protein furry homolog isoform X8 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fry_C pfam19421
Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a ...
 2277-2979 0e+00

Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.


:

Pssm-ID: 466072  Cd Length: 633  Bit Score: 1208.44  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2277 ASKELPGKTLDFHFDISETPIIGRRYDELQNSSGRDGKPRAMAVTRSASSTSSGSNSNVLVPVSWKRPQYSQKRTKEKLV 2356
Cdd:pfam19421    1 SSKELPGKTLDFHFDISETPIIGRRYDELHGSAGRDGKPRVIAVTRSTSSTSSGSNSNVLVPVSWKRPQLSQKRTREKLV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2357 HVLSLCGQEVGLSKNPSVIFSSCGDLDLPEHQTSLVSSEDGPREQENMDDTNSEQQFRVFRDFDFLDVELEDGEelqGES 2436
Cdd:pfam19421   81 NVLSLCGQEVGLTKNPSVIFSSCGDLDLMDQQTSLVSSEDGIREEENMDDTTSEQQFRVFRDFDFLDVELEDGE---GES 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2437 MDNFNWGVRRRSLDSLDKCDMQILEERQLSRSTPSLNKMSHE-DSDESSEEDLTASQILEHSDLIMNLSPSEEANPMELL 2515
Cdd:pfam19421  158 MDNFNWGVRRRSLDSLDKGDTPSLEESQLSGSTPSLNLTNHEdSDESSEEESLTASQILSHSQLLNSDSPTEEPNHVDSL 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2516 TSACDSAPADPHSFNTRMANFEASLPDINNLQisegskaeavpeeedttvheddlsssinelpaafecsdsfsldmteae 2595
Cdd:pfam19421  238 SQSQDSSSADEESLRAETPSLEVSLPEDASAR------------------------------------------------ 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2596 ekgnrgldqytlasfGEGDRGVSPPPSPFFSAILAAFQPAACDDAEEAWRSHINQLMCDSDGSCAVYTFHVFSSLFKNIQ 2675
Cdd:pfam19421  270 ---------------GFPEIQSSPPPSPFFSAILAAFQPVVCDDAEEAWRCHVNQLVSDSDGSCAVYTFHVFSSLFQNIQ 334

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2676 KRFCFLTCDAASYLGDNLRGIGSKFVSSSQMLTSCSECPTLFVDAETLLSCGLLDKLKFSVLELQEYLDTYNNRKEATLS 2755
Cdd:pfam19421  335 RKFCSLTCDAVSYLGDSLRGIGSKFLSSSQMLTSCSECPTLFVDAETLMSCGLLEKLKFSVLELQEYLDTYNNKKEAAES 414

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2756 WLANCKATFAGGSRDGVITCQPGDSEEKqmeslaQLELCQRLYKLHFQLLLLYQSYCKLIGQVHEVSSVPELLNMSRELS 2835
Cdd:pfam19421  415 WLDNCKATFPRGSGDGVITCQPADQEEK------QLELCQRLYKLHFQLLLLFQSYCKLIGQVHAISSVPELINMSEELA 488

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2836 DLKRNLKEATAAIATDPLYIEG-AWSEPTFTSTEAAIQSMLECLKNNELGKALRQIKECRSLWPNDIFGSSSDDEVQTLL 2914
Cdd:pfam19421  489 QLESSLKEAEASVTSDELAQEEsASSEPSFSSSEAAVQSILESLRNKEFSTAIRQIKECRSLWPNDIFGSSSEDEVQTLL 568

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720413842 2915 NIYFRHQTLGQTGTYALVGSNHSLTEICTKLMELNMEIRDMIRRAQNYRVLTAFLPDSSVSGTSL 2979
Cdd:pfam19421  569 NIYFRHQTLGQTGTFALVGSNQDLSEICSKLMELNLEIRDMIRRAQGYRALTAFLPDSSVSGSSL 633
MOR2-PAG1_N pfam14222
Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that ...
 115-621 0e+00

Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that are involved in cell morphogenesis.


:

Pssm-ID: 464107  Cd Length: 554  Bit Score: 618.83  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  115 ERRDLAIDFIFSLVLIEVLKQIPLHPVIDSLIHDIINLAFKHFKYKEGYLGPNTGNMHIVADLYAEVIGVLAQAKFPAVK 194
Cdd:pfam14222    1 ERKSLASIYILCRVLIEIVKQSPLDALTEELGDKLEEIVFGQLKTADPDQLSSSPNRSANWNLFAELLGVLSEIRFVSVS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  195 KKFMAELKELRHKEQSPYVVQSIISLIMGMKFFRIKMYPVEDFEASLQFMQECAHYFLEVKDKDIKHALAGLFVEILVPV 274
Cdd:pfam14222   81 DRFIAELEKLPKGLSSKDLEAKIELLIRGMRYLRIKVYPEEAFEESADFMQSLAKFFLNAHGQRVKHAYAEVLVELLLPV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  275 AAAVKNEVNVPCLRNFVESLYDTTLELSSRKKHSLALYPLVTCLLCVSQKQLFLNRWHVFLNNCLSNLKNKdpKMARVAL 354
Cdd:pfam14222  161 AATATAEVNHPKWKEAVELLYPRAAKMASKPRHWNVAFPLVTTLLCVSPKEFFLSNWLSLIESLISKLKDK--TTRPVAL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  355 ESLYRLLWVYMIRIKcESNTATQSRLITITTTLFPKGSRGVVPRDMPLNIFVKIIQFIAQERLDFAMKEIIFDFLCVGKP 434
Cdd:pfam14222  239 QGLSRLLWVYLYRCT-ESLNTTTRKLESILKLLFPPGKKTWLPADPPLDPLVQIIRFIGFKHPDFCFENIIFPLLNADLF 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  435 --AKAFSLNPERMNIGLRAFLVIADSLQQKDGEPPMPVTGAVLPSGN--TLRVKKTYLSKTlTEEEAKMIGMSLYYSQVR 510
Cdd:pfam14222  318 ngLKLENLNPERMIIGIRAFLAILSDLEKGEQRPPFPQSFGTLPSPSssALRSKEENLSRP-VDTLALSEGIKDYYERFC 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  511 KAVGNILRHLDKEVGRCMML-------------TNVQMLNKEPED-MITGERKPKIDLFRTCVAAIPRLLPDGMSKLELI 576
Cdd:pfam14222  397 KILGKILILCDNTFGGQAVLdekfssptpktpiSETFNFSRRPDDnAYDGQRQPFYELLHTAVQAIPRCLPSSIPFNSLI 476

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*
gi 1720413842  577 DLLARLSIHMDDELRHIAQNSLQGLLVdfSDWREDVLFGFTNFLL 621
Cdd:pfam14222  477 ELLCRGTVHVDPNIAESAAQALKRIAR--PSHAQQVITGFARFIF 519
MOR2-PAG1_C pfam14225
Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that ...
 2000-2253 4.76e-62

Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.


:

Pssm-ID: 464109  Cd Length: 252  Bit Score: 213.49  E-value: 4.76e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2000 ATIFWVTVALMESDFEFEYLMALRLLNRLLAHMPLEKAENREKLEKLQAQlKW-ADFPGLQQLLLKGFTSLTTTDLTLQL 2078
Cdd:pfam14225    1 PQLFWTTVACLETIHEHEFLEALRLLEKLLDKLDLDDPDVVEKLLSSQPQ-KWeGKFEGLQPLLLKGLRSSVTLEPTLKL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2079 FSLLTSVSKVPMVDSSQAiGFPLNVLCLLPQLIQHFENP--NQFCKDIAERIAQVCLEEKnpkLSNLAHVMTLYKTHSYt 2156
Cdd:pfam14225   80 LDRLTKLPDDRLVGPSDS-RLLFLVLANLPRFLHALDDPdiDPDCIETAENLAELAEEQG---LPSLARVLTSYAKGRF- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2157 RDCATWVNVVCRYLHEAYADITLN-MVTYLAELLEKGLPSMQQPLLQVIYSLLSYMDLSVVPVKQFNMEVLKTIEKYVQS 2235
Cdd:pfam14225  155 RTSDDFLKQVVSYLREAYFPDYEFqMLTFLLGLLTNGPPWVKVKTLQILKVLLPEIDMRRPEIAGHGADLISPLLRLLQT 234

                          250
                   ....*....|....*...
gi 1720413842 2236 IHWREALNILKLVVSRSA 2253
Cdd:pfam14225  235 DLCMQALEVLDEIVTISG 252
MOR2-PAG1_mid super family cl20509
Cell morphogenesis central region; This family is the conserved central region of proteins ...
 684-1848 2.11e-25

Cell morphogenesis central region; This family is the conserved central region of proteins that are involved in cell morphogenesis.


The actual alignment was detected with superfamily member pfam14228:

Pssm-ID: 433790 [Multi-domain]  Cd Length: 1113  Bit Score: 115.89  E-value: 2.11e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  684 HCSVLHAVegfALVLLCSFQVATRKLSVLILKEIRALF-----LALGQPED-----DDRP--MIDVMDQLSSSILESfih 751
Cdd:pfam14228    5 RPSGLDAV---GLIFLSSVDVQIRHTALELLRCVRALYndlrdMSSKERSDvswknNKEPifIIDVFEENGDDIVQQ--- 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  752 vAVSDSAtlpptHNVDLQwlVEWNAVlvnshydvksPSHVW---IFAQSVKDPWVLCLFSFLRQENlpKHCPTALSYAwp 828
Cdd:pfam14228   79 -CYWDSG-----RPYDMR--RESDAI----------PPDLTlqsILESPDKGRWARCLSELVKYAA--ELCPSSVQEA-- 136

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  829 yaftRLQSVMPLVDPNSPVNAKKTSTASSGDNYVTLWRNYLIlcFGVAKPsimspghlrastpeimattPDgtvsyDNKA 908
Cdd:pfam14228  137 ----RLEVVQRLAQITPVELGGKAHQSQDADNKLDQWLLYSM--FACSCP-------------------PD-----DVED 186

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  909 IGTPSVGVLLKQLVPLMRLESIEITESLVLGFGRTNSLVFRELVEELHPLMKEA---LERRPENKKRRERRDLLRLQLLR 985
Cdd:pfam14228  187 TKSHSAKELYHLIFPSLKSGSETHIHAATLALGHSHLEVCEPMFGELRSFLDEVateTESKPKWKSQKARREELRVHVAN 266

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  986 IFELLADagvisDSTNGALERDTLaLGALFLEYV-DLTRMLLEA--ENDKEVEILKDIRAhfSAMVANLIQCVPVHHRRF 1062
Cdd:pfam14228  267 IYRMVAE-----NFWPGMLIRKPV-FRLHVLKFIeDTVRYITTSplENFQDLQPLRFALA--SVLRSLAPEFVKSKSERF 338

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1063 lfpQQSLRHHLFILFSQWAGPFSIMFTPlDRYSDRNHQITRY----------------------------QYCALKAMSA 1114
Cdd:pfam14228  339 ---DPRTRKRLFDLLASWCDDTGTVWSQ-DGVSDYRREVERYkssqnsrskdsvdkisfdkevneqveaiQWIAMNAMAA 414

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1115 VLCcGPVFDNVGLSPDGYLYKWLDNI--------------------------------LACQD------LRVHqLGCEVV 1156
Cdd:pfam14228  415 LLY-GPCFDDNARKMSGRVIAWINGLflepaprapfgyspadprtpsyskfagegvrgLGGKDrhrggpLRVH-LAKVAL 492

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1157 MLLLELNPDqinLFNWAIDRCYTGSYQLASGCFKAIATVCGNRNYP-FDIVTLLNLVLFKASDTNREIYEVSMQLMQILE 1235
Cdd:pfam14228  493 KNLLQTNLD---LFPACIDQCYSSDASIADGYFSVLAEVYMRQEIPrCDIQRLLSLILYKVVDPSRRIRDDALQMLETLS 569

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1236 AKLFVHSkkvAEQRPGSILYGTHGPLPPLYSVSLALLSCELARMYPELTLPLFSEVSQR-FPTTHPNGRQIMLTYLLPWL 1314
Cdd:pfam14228  570 VREWAED---GEEGTGRYRAAVVGNLPDSYQQFQYKLSAKLAKDHPELSELLCEEIMQRqLDAVDIIAQHQVLTCMAPWI 646

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1315 HNIELVdsrlllpgsspsspedevkdregevtashGLKGNGWgspeaTSLVLNNLMYMTAKYGDEVPGaEMENAWNALAN 1394
Cdd:pfam14228  647 ENLNFL-----------------------------KLWESGW-----SERLLKSLYYVTWRHGDQFPD-EIEKLWRTIAS 691

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1395 NEKwsnNLRVTLQFLISLCGVSSDT--------ILLPYI---KKVATYLCRNNTIQTMEELLFELQQ------TEPVNPi 1457
Cdd:pfam14228  692 KPR---NISPVLDFLISKGIEDCDSnasaeitgAFATYFsvaKRVSLYLARICPQQTIDHLVYELAQrmleesVEPSRP- 767

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1458 vqhcdnppfyrftasskasAAASGTTSSSNTVVAGQDsfPDPEESKILKESDDRFSNVIrAHTRLESRYSNSSGG----- 1532
Cdd:pfam14228  768 -------------------SDGAFDLESSAVLEFSQG--PAPVQVAQLLDPQPHMSPLL-VRSSLEGPLRNASGSlswrt 825

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1533 SYDEDKNDPISPYTGWLLSITEAKQ-----PQPLPMPCSGGcwaPLV-------------------DYLPET-------- 1580
Cdd:pfam14228  826 VTGRSMSGPLNTMPEVVAVDTHTGRsgqlfTGSGPLPNMSG---PLMgvrsstgslrshhvsrdsgDYFIDTpnsveeir 902

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1581 ITP-----------RGPLH---RCNIAVIFMTEMVVDHSvrEDWALHLPLLLHAVFLGLDHYRPEVFEHSKklllhllia 1646
Cdd:pfam14228  903 ITPvvnaselqsalQGHQHwlsRADIALILLAEIAYEND--EDFRSHLPLLFHVTFVSMDSSEDIVLKHCQ--------- 971

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1647 lscnsnfHAIASVL--LQTREMgeaktltmqpayqpeylytggfdflredqsspvpdsglnssstsssislggssgnlpq 1724
Cdd:pfam14228  972 -------HLLVNLLysLAGRHL---------------------------------------------------------- 986

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1725 mtqEVEDVEAAT-ETDEKASKLIEFLTTRAFGPLWCHEDITPKNQNSKSAEQLSNFLRHVVS--VFKDSrsgfhLEQHLS 1801
Cdd:pfam14228  987 ---ELYDVEHGDgEYKQQVVSLIKYVQSKRGSRMWENEDMTLTRTELPSAALLSALVLSMVDaiFFQGD-----LREKWG 1058

                         1290      1300      1310      1320
                   ....*....|....*....|....*....|....*....|....*..
gi 1720413842 1802 EVALQTALASSSRHYAGRSFQIFRALKQPLSAHALSDLLSRLVEVIG 1848
Cdd:pfam14228 1059 EEALKWAMECTSRHLACRSHQIYRALRPSVTSDTCVSLLRCLHRCLG 1105
 
Name Accession Description Interval E-value
Fry_C pfam19421
Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a ...
 2277-2979 0e+00

Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.


Pssm-ID: 466072  Cd Length: 633  Bit Score: 1208.44  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2277 ASKELPGKTLDFHFDISETPIIGRRYDELQNSSGRDGKPRAMAVTRSASSTSSGSNSNVLVPVSWKRPQYSQKRTKEKLV 2356
Cdd:pfam19421    1 SSKELPGKTLDFHFDISETPIIGRRYDELHGSAGRDGKPRVIAVTRSTSSTSSGSNSNVLVPVSWKRPQLSQKRTREKLV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2357 HVLSLCGQEVGLSKNPSVIFSSCGDLDLPEHQTSLVSSEDGPREQENMDDTNSEQQFRVFRDFDFLDVELEDGEelqGES 2436
Cdd:pfam19421   81 NVLSLCGQEVGLTKNPSVIFSSCGDLDLMDQQTSLVSSEDGIREEENMDDTTSEQQFRVFRDFDFLDVELEDGE---GES 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2437 MDNFNWGVRRRSLDSLDKCDMQILEERQLSRSTPSLNKMSHE-DSDESSEEDLTASQILEHSDLIMNLSPSEEANPMELL 2515
Cdd:pfam19421  158 MDNFNWGVRRRSLDSLDKGDTPSLEESQLSGSTPSLNLTNHEdSDESSEEESLTASQILSHSQLLNSDSPTEEPNHVDSL 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2516 TSACDSAPADPHSFNTRMANFEASLPDINNLQisegskaeavpeeedttvheddlsssinelpaafecsdsfsldmteae 2595
Cdd:pfam19421  238 SQSQDSSSADEESLRAETPSLEVSLPEDASAR------------------------------------------------ 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2596 ekgnrgldqytlasfGEGDRGVSPPPSPFFSAILAAFQPAACDDAEEAWRSHINQLMCDSDGSCAVYTFHVFSSLFKNIQ 2675
Cdd:pfam19421  270 ---------------GFPEIQSSPPPSPFFSAILAAFQPVVCDDAEEAWRCHVNQLVSDSDGSCAVYTFHVFSSLFQNIQ 334

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2676 KRFCFLTCDAASYLGDNLRGIGSKFVSSSQMLTSCSECPTLFVDAETLLSCGLLDKLKFSVLELQEYLDTYNNRKEATLS 2755
Cdd:pfam19421  335 RKFCSLTCDAVSYLGDSLRGIGSKFLSSSQMLTSCSECPTLFVDAETLMSCGLLEKLKFSVLELQEYLDTYNNKKEAAES 414

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2756 WLANCKATFAGGSRDGVITCQPGDSEEKqmeslaQLELCQRLYKLHFQLLLLYQSYCKLIGQVHEVSSVPELLNMSRELS 2835
Cdd:pfam19421  415 WLDNCKATFPRGSGDGVITCQPADQEEK------QLELCQRLYKLHFQLLLLFQSYCKLIGQVHAISSVPELINMSEELA 488

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2836 DLKRNLKEATAAIATDPLYIEG-AWSEPTFTSTEAAIQSMLECLKNNELGKALRQIKECRSLWPNDIFGSSSDDEVQTLL 2914
Cdd:pfam19421  489 QLESSLKEAEASVTSDELAQEEsASSEPSFSSSEAAVQSILESLRNKEFSTAIRQIKECRSLWPNDIFGSSSEDEVQTLL 568

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720413842 2915 NIYFRHQTLGQTGTYALVGSNHSLTEICTKLMELNMEIRDMIRRAQNYRVLTAFLPDSSVSGTSL 2979
Cdd:pfam19421  569 NIYFRHQTLGQTGTFALVGSNQDLSEICSKLMELNLEIRDMIRRAQGYRALTAFLPDSSVSGSSL 633
MOR2-PAG1_N pfam14222
Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that ...
 115-621 0e+00

Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464107  Cd Length: 554  Bit Score: 618.83  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  115 ERRDLAIDFIFSLVLIEVLKQIPLHPVIDSLIHDIINLAFKHFKYKEGYLGPNTGNMHIVADLYAEVIGVLAQAKFPAVK 194
Cdd:pfam14222    1 ERKSLASIYILCRVLIEIVKQSPLDALTEELGDKLEEIVFGQLKTADPDQLSSSPNRSANWNLFAELLGVLSEIRFVSVS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  195 KKFMAELKELRHKEQSPYVVQSIISLIMGMKFFRIKMYPVEDFEASLQFMQECAHYFLEVKDKDIKHALAGLFVEILVPV 274
Cdd:pfam14222   81 DRFIAELEKLPKGLSSKDLEAKIELLIRGMRYLRIKVYPEEAFEESADFMQSLAKFFLNAHGQRVKHAYAEVLVELLLPV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  275 AAAVKNEVNVPCLRNFVESLYDTTLELSSRKKHSLALYPLVTCLLCVSQKQLFLNRWHVFLNNCLSNLKNKdpKMARVAL 354
Cdd:pfam14222  161 AATATAEVNHPKWKEAVELLYPRAAKMASKPRHWNVAFPLVTTLLCVSPKEFFLSNWLSLIESLISKLKDK--TTRPVAL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  355 ESLYRLLWVYMIRIKcESNTATQSRLITITTTLFPKGSRGVVPRDMPLNIFVKIIQFIAQERLDFAMKEIIFDFLCVGKP 434
Cdd:pfam14222  239 QGLSRLLWVYLYRCT-ESLNTTTRKLESILKLLFPPGKKTWLPADPPLDPLVQIIRFIGFKHPDFCFENIIFPLLNADLF 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  435 --AKAFSLNPERMNIGLRAFLVIADSLQQKDGEPPMPVTGAVLPSGN--TLRVKKTYLSKTlTEEEAKMIGMSLYYSQVR 510
Cdd:pfam14222  318 ngLKLENLNPERMIIGIRAFLAILSDLEKGEQRPPFPQSFGTLPSPSssALRSKEENLSRP-VDTLALSEGIKDYYERFC 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  511 KAVGNILRHLDKEVGRCMML-------------TNVQMLNKEPED-MITGERKPKIDLFRTCVAAIPRLLPDGMSKLELI 576
Cdd:pfam14222  397 KILGKILILCDNTFGGQAVLdekfssptpktpiSETFNFSRRPDDnAYDGQRQPFYELLHTAVQAIPRCLPSSIPFNSLI 476

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*
gi 1720413842  577 DLLARLSIHMDDELRHIAQNSLQGLLVdfSDWREDVLFGFTNFLL 621
Cdd:pfam14222  477 ELLCRGTVHVDPNIAESAAQALKRIAR--PSHAQQVITGFARFIF 519
MOR2-PAG1_C pfam14225
Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that ...
 2000-2253 4.76e-62

Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464109  Cd Length: 252  Bit Score: 213.49  E-value: 4.76e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2000 ATIFWVTVALMESDFEFEYLMALRLLNRLLAHMPLEKAENREKLEKLQAQlKW-ADFPGLQQLLLKGFTSLTTTDLTLQL 2078
Cdd:pfam14225    1 PQLFWTTVACLETIHEHEFLEALRLLEKLLDKLDLDDPDVVEKLLSSQPQ-KWeGKFEGLQPLLLKGLRSSVTLEPTLKL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2079 FSLLTSVSKVPMVDSSQAiGFPLNVLCLLPQLIQHFENP--NQFCKDIAERIAQVCLEEKnpkLSNLAHVMTLYKTHSYt 2156
Cdd:pfam14225   80 LDRLTKLPDDRLVGPSDS-RLLFLVLANLPRFLHALDDPdiDPDCIETAENLAELAEEQG---LPSLARVLTSYAKGRF- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2157 RDCATWVNVVCRYLHEAYADITLN-MVTYLAELLEKGLPSMQQPLLQVIYSLLSYMDLSVVPVKQFNMEVLKTIEKYVQS 2235
Cdd:pfam14225  155 RTSDDFLKQVVSYLREAYFPDYEFqMLTFLLGLLTNGPPWVKVKTLQILKVLLPEIDMRRPEIAGHGADLISPLLRLLQT 234

                          250
                   ....*....|....*...
gi 1720413842 2236 IHWREALNILKLVVSRSA 2253
Cdd:pfam14225  235 DLCMQALEVLDEIVTISG 252
MOR2-PAG1_mid pfam14228
Cell morphogenesis central region; This family is the conserved central region of proteins ...
 684-1848 2.11e-25

Cell morphogenesis central region; This family is the conserved central region of proteins that are involved in cell morphogenesis.


Pssm-ID: 433790 [Multi-domain]  Cd Length: 1113  Bit Score: 115.89  E-value: 2.11e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  684 HCSVLHAVegfALVLLCSFQVATRKLSVLILKEIRALF-----LALGQPED-----DDRP--MIDVMDQLSSSILESfih 751
Cdd:pfam14228    5 RPSGLDAV---GLIFLSSVDVQIRHTALELLRCVRALYndlrdMSSKERSDvswknNKEPifIIDVFEENGDDIVQQ--- 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  752 vAVSDSAtlpptHNVDLQwlVEWNAVlvnshydvksPSHVW---IFAQSVKDPWVLCLFSFLRQENlpKHCPTALSYAwp 828
Cdd:pfam14228   79 -CYWDSG-----RPYDMR--RESDAI----------PPDLTlqsILESPDKGRWARCLSELVKYAA--ELCPSSVQEA-- 136

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  829 yaftRLQSVMPLVDPNSPVNAKKTSTASSGDNYVTLWRNYLIlcFGVAKPsimspghlrastpeimattPDgtvsyDNKA 908
Cdd:pfam14228  137 ----RLEVVQRLAQITPVELGGKAHQSQDADNKLDQWLLYSM--FACSCP-------------------PD-----DVED 186

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  909 IGTPSVGVLLKQLVPLMRLESIEITESLVLGFGRTNSLVFRELVEELHPLMKEA---LERRPENKKRRERRDLLRLQLLR 985
Cdd:pfam14228  187 TKSHSAKELYHLIFPSLKSGSETHIHAATLALGHSHLEVCEPMFGELRSFLDEVateTESKPKWKSQKARREELRVHVAN 266

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  986 IFELLADagvisDSTNGALERDTLaLGALFLEYV-DLTRMLLEA--ENDKEVEILKDIRAhfSAMVANLIQCVPVHHRRF 1062
Cdd:pfam14228  267 IYRMVAE-----NFWPGMLIRKPV-FRLHVLKFIeDTVRYITTSplENFQDLQPLRFALA--SVLRSLAPEFVKSKSERF 338

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1063 lfpQQSLRHHLFILFSQWAGPFSIMFTPlDRYSDRNHQITRY----------------------------QYCALKAMSA 1114
Cdd:pfam14228  339 ---DPRTRKRLFDLLASWCDDTGTVWSQ-DGVSDYRREVERYkssqnsrskdsvdkisfdkevneqveaiQWIAMNAMAA 414

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1115 VLCcGPVFDNVGLSPDGYLYKWLDNI--------------------------------LACQD------LRVHqLGCEVV 1156
Cdd:pfam14228  415 LLY-GPCFDDNARKMSGRVIAWINGLflepaprapfgyspadprtpsyskfagegvrgLGGKDrhrggpLRVH-LAKVAL 492

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1157 MLLLELNPDqinLFNWAIDRCYTGSYQLASGCFKAIATVCGNRNYP-FDIVTLLNLVLFKASDTNREIYEVSMQLMQILE 1235
Cdd:pfam14228  493 KNLLQTNLD---LFPACIDQCYSSDASIADGYFSVLAEVYMRQEIPrCDIQRLLSLILYKVVDPSRRIRDDALQMLETLS 569

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1236 AKLFVHSkkvAEQRPGSILYGTHGPLPPLYSVSLALLSCELARMYPELTLPLFSEVSQR-FPTTHPNGRQIMLTYLLPWL 1314
Cdd:pfam14228  570 VREWAED---GEEGTGRYRAAVVGNLPDSYQQFQYKLSAKLAKDHPELSELLCEEIMQRqLDAVDIIAQHQVLTCMAPWI 646

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1315 HNIELVdsrlllpgsspsspedevkdregevtashGLKGNGWgspeaTSLVLNNLMYMTAKYGDEVPGaEMENAWNALAN 1394
Cdd:pfam14228  647 ENLNFL-----------------------------KLWESGW-----SERLLKSLYYVTWRHGDQFPD-EIEKLWRTIAS 691

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1395 NEKwsnNLRVTLQFLISLCGVSSDT--------ILLPYI---KKVATYLCRNNTIQTMEELLFELQQ------TEPVNPi 1457
Cdd:pfam14228  692 KPR---NISPVLDFLISKGIEDCDSnasaeitgAFATYFsvaKRVSLYLARICPQQTIDHLVYELAQrmleesVEPSRP- 767

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1458 vqhcdnppfyrftasskasAAASGTTSSSNTVVAGQDsfPDPEESKILKESDDRFSNVIrAHTRLESRYSNSSGG----- 1532
Cdd:pfam14228  768 -------------------SDGAFDLESSAVLEFSQG--PAPVQVAQLLDPQPHMSPLL-VRSSLEGPLRNASGSlswrt 825

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1533 SYDEDKNDPISPYTGWLLSITEAKQ-----PQPLPMPCSGGcwaPLV-------------------DYLPET-------- 1580
Cdd:pfam14228  826 VTGRSMSGPLNTMPEVVAVDTHTGRsgqlfTGSGPLPNMSG---PLMgvrsstgslrshhvsrdsgDYFIDTpnsveeir 902

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1581 ITP-----------RGPLH---RCNIAVIFMTEMVVDHSvrEDWALHLPLLLHAVFLGLDHYRPEVFEHSKklllhllia 1646
Cdd:pfam14228  903 ITPvvnaselqsalQGHQHwlsRADIALILLAEIAYEND--EDFRSHLPLLFHVTFVSMDSSEDIVLKHCQ--------- 971

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1647 lscnsnfHAIASVL--LQTREMgeaktltmqpayqpeylytggfdflredqsspvpdsglnssstsssislggssgnlpq 1724
Cdd:pfam14228  972 -------HLLVNLLysLAGRHL---------------------------------------------------------- 986

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1725 mtqEVEDVEAAT-ETDEKASKLIEFLTTRAFGPLWCHEDITPKNQNSKSAEQLSNFLRHVVS--VFKDSrsgfhLEQHLS 1801
Cdd:pfam14228  987 ---ELYDVEHGDgEYKQQVVSLIKYVQSKRGSRMWENEDMTLTRTELPSAALLSALVLSMVDaiFFQGD-----LREKWG 1058

                         1290      1300      1310      1320
                   ....*....|....*....|....*....|....*....|....*..
gi 1720413842 1802 EVALQTALASSSRHYAGRSFQIFRALKQPLSAHALSDLLSRLVEVIG 1848
Cdd:pfam14228 1059 EEALKWAMECTSRHLACRSHQIYRALRPSVTSDTCVSLLRCLHRCLG 1105
 
Name Accession Description Interval E-value
Fry_C pfam19421
Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a ...
 2277-2979 0e+00

Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.


Pssm-ID: 466072  Cd Length: 633  Bit Score: 1208.44  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2277 ASKELPGKTLDFHFDISETPIIGRRYDELQNSSGRDGKPRAMAVTRSASSTSSGSNSNVLVPVSWKRPQYSQKRTKEKLV 2356
Cdd:pfam19421    1 SSKELPGKTLDFHFDISETPIIGRRYDELHGSAGRDGKPRVIAVTRSTSSTSSGSNSNVLVPVSWKRPQLSQKRTREKLV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2357 HVLSLCGQEVGLSKNPSVIFSSCGDLDLPEHQTSLVSSEDGPREQENMDDTNSEQQFRVFRDFDFLDVELEDGEelqGES 2436
Cdd:pfam19421   81 NVLSLCGQEVGLTKNPSVIFSSCGDLDLMDQQTSLVSSEDGIREEENMDDTTSEQQFRVFRDFDFLDVELEDGE---GES 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2437 MDNFNWGVRRRSLDSLDKCDMQILEERQLSRSTPSLNKMSHE-DSDESSEEDLTASQILEHSDLIMNLSPSEEANPMELL 2515
Cdd:pfam19421  158 MDNFNWGVRRRSLDSLDKGDTPSLEESQLSGSTPSLNLTNHEdSDESSEEESLTASQILSHSQLLNSDSPTEEPNHVDSL 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2516 TSACDSAPADPHSFNTRMANFEASLPDINNLQisegskaeavpeeedttvheddlsssinelpaafecsdsfsldmteae 2595
Cdd:pfam19421  238 SQSQDSSSADEESLRAETPSLEVSLPEDASAR------------------------------------------------ 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2596 ekgnrgldqytlasfGEGDRGVSPPPSPFFSAILAAFQPAACDDAEEAWRSHINQLMCDSDGSCAVYTFHVFSSLFKNIQ 2675
Cdd:pfam19421  270 ---------------GFPEIQSSPPPSPFFSAILAAFQPVVCDDAEEAWRCHVNQLVSDSDGSCAVYTFHVFSSLFQNIQ 334

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2676 KRFCFLTCDAASYLGDNLRGIGSKFVSSSQMLTSCSECPTLFVDAETLLSCGLLDKLKFSVLELQEYLDTYNNRKEATLS 2755
Cdd:pfam19421  335 RKFCSLTCDAVSYLGDSLRGIGSKFLSSSQMLTSCSECPTLFVDAETLMSCGLLEKLKFSVLELQEYLDTYNNKKEAAES 414

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2756 WLANCKATFAGGSRDGVITCQPGDSEEKqmeslaQLELCQRLYKLHFQLLLLYQSYCKLIGQVHEVSSVPELLNMSRELS 2835
Cdd:pfam19421  415 WLDNCKATFPRGSGDGVITCQPADQEEK------QLELCQRLYKLHFQLLLLFQSYCKLIGQVHAISSVPELINMSEELA 488

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2836 DLKRNLKEATAAIATDPLYIEG-AWSEPTFTSTEAAIQSMLECLKNNELGKALRQIKECRSLWPNDIFGSSSDDEVQTLL 2914
Cdd:pfam19421  489 QLESSLKEAEASVTSDELAQEEsASSEPSFSSSEAAVQSILESLRNKEFSTAIRQIKECRSLWPNDIFGSSSEDEVQTLL 568

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720413842 2915 NIYFRHQTLGQTGTYALVGSNHSLTEICTKLMELNMEIRDMIRRAQNYRVLTAFLPDSSVSGTSL 2979
Cdd:pfam19421  569 NIYFRHQTLGQTGTFALVGSNQDLSEICSKLMELNLEIRDMIRRAQGYRALTAFLPDSSVSGSSL 633
MOR2-PAG1_N pfam14222
Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that ...
 115-621 0e+00

Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464107  Cd Length: 554  Bit Score: 618.83  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  115 ERRDLAIDFIFSLVLIEVLKQIPLHPVIDSLIHDIINLAFKHFKYKEGYLGPNTGNMHIVADLYAEVIGVLAQAKFPAVK 194
Cdd:pfam14222    1 ERKSLASIYILCRVLIEIVKQSPLDALTEELGDKLEEIVFGQLKTADPDQLSSSPNRSANWNLFAELLGVLSEIRFVSVS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  195 KKFMAELKELRHKEQSPYVVQSIISLIMGMKFFRIKMYPVEDFEASLQFMQECAHYFLEVKDKDIKHALAGLFVEILVPV 274
Cdd:pfam14222   81 DRFIAELEKLPKGLSSKDLEAKIELLIRGMRYLRIKVYPEEAFEESADFMQSLAKFFLNAHGQRVKHAYAEVLVELLLPV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  275 AAAVKNEVNVPCLRNFVESLYDTTLELSSRKKHSLALYPLVTCLLCVSQKQLFLNRWHVFLNNCLSNLKNKdpKMARVAL 354
Cdd:pfam14222  161 AATATAEVNHPKWKEAVELLYPRAAKMASKPRHWNVAFPLVTTLLCVSPKEFFLSNWLSLIESLISKLKDK--TTRPVAL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  355 ESLYRLLWVYMIRIKcESNTATQSRLITITTTLFPKGSRGVVPRDMPLNIFVKIIQFIAQERLDFAMKEIIFDFLCVGKP 434
Cdd:pfam14222  239 QGLSRLLWVYLYRCT-ESLNTTTRKLESILKLLFPPGKKTWLPADPPLDPLVQIIRFIGFKHPDFCFENIIFPLLNADLF 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  435 --AKAFSLNPERMNIGLRAFLVIADSLQQKDGEPPMPVTGAVLPSGN--TLRVKKTYLSKTlTEEEAKMIGMSLYYSQVR 510
Cdd:pfam14222  318 ngLKLENLNPERMIIGIRAFLAILSDLEKGEQRPPFPQSFGTLPSPSssALRSKEENLSRP-VDTLALSEGIKDYYERFC 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  511 KAVGNILRHLDKEVGRCMML-------------TNVQMLNKEPED-MITGERKPKIDLFRTCVAAIPRLLPDGMSKLELI 576
Cdd:pfam14222  397 KILGKILILCDNTFGGQAVLdekfssptpktpiSETFNFSRRPDDnAYDGQRQPFYELLHTAVQAIPRCLPSSIPFNSLI 476

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*
gi 1720413842  577 DLLARLSIHMDDELRHIAQNSLQGLLVdfSDWREDVLFGFTNFLL 621
Cdd:pfam14222  477 ELLCRGTVHVDPNIAESAAQALKRIAR--PSHAQQVITGFARFIF 519
MOR2-PAG1_C pfam14225
Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that ...
 2000-2253 4.76e-62

Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464109  Cd Length: 252  Bit Score: 213.49  E-value: 4.76e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2000 ATIFWVTVALMESDFEFEYLMALRLLNRLLAHMPLEKAENREKLEKLQAQlKW-ADFPGLQQLLLKGFTSLTTTDLTLQL 2078
Cdd:pfam14225    1 PQLFWTTVACLETIHEHEFLEALRLLEKLLDKLDLDDPDVVEKLLSSQPQ-KWeGKFEGLQPLLLKGLRSSVTLEPTLKL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2079 FSLLTSVSKVPMVDSSQAiGFPLNVLCLLPQLIQHFENP--NQFCKDIAERIAQVCLEEKnpkLSNLAHVMTLYKTHSYt 2156
Cdd:pfam14225   80 LDRLTKLPDDRLVGPSDS-RLLFLVLANLPRFLHALDDPdiDPDCIETAENLAELAEEQG---LPSLARVLTSYAKGRF- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 2157 RDCATWVNVVCRYLHEAYADITLN-MVTYLAELLEKGLPSMQQPLLQVIYSLLSYMDLSVVPVKQFNMEVLKTIEKYVQS 2235
Cdd:pfam14225  155 RTSDDFLKQVVSYLREAYFPDYEFqMLTFLLGLLTNGPPWVKVKTLQILKVLLPEIDMRRPEIAGHGADLISPLLRLLQT 234

                          250
                   ....*....|....*...
gi 1720413842 2236 IHWREALNILKLVVSRSA 2253
Cdd:pfam14225  235 DLCMQALEVLDEIVTISG 252
MOR2-PAG1_mid pfam14228
Cell morphogenesis central region; This family is the conserved central region of proteins ...
 684-1848 2.11e-25

Cell morphogenesis central region; This family is the conserved central region of proteins that are involved in cell morphogenesis.


Pssm-ID: 433790 [Multi-domain]  Cd Length: 1113  Bit Score: 115.89  E-value: 2.11e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  684 HCSVLHAVegfALVLLCSFQVATRKLSVLILKEIRALF-----LALGQPED-----DDRP--MIDVMDQLSSSILESfih 751
Cdd:pfam14228    5 RPSGLDAV---GLIFLSSVDVQIRHTALELLRCVRALYndlrdMSSKERSDvswknNKEPifIIDVFEENGDDIVQQ--- 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  752 vAVSDSAtlpptHNVDLQwlVEWNAVlvnshydvksPSHVW---IFAQSVKDPWVLCLFSFLRQENlpKHCPTALSYAwp 828
Cdd:pfam14228   79 -CYWDSG-----RPYDMR--RESDAI----------PPDLTlqsILESPDKGRWARCLSELVKYAA--ELCPSSVQEA-- 136

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  829 yaftRLQSVMPLVDPNSPVNAKKTSTASSGDNYVTLWRNYLIlcFGVAKPsimspghlrastpeimattPDgtvsyDNKA 908
Cdd:pfam14228  137 ----RLEVVQRLAQITPVELGGKAHQSQDADNKLDQWLLYSM--FACSCP-------------------PD-----DVED 186

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  909 IGTPSVGVLLKQLVPLMRLESIEITESLVLGFGRTNSLVFRELVEELHPLMKEA---LERRPENKKRRERRDLLRLQLLR 985
Cdd:pfam14228  187 TKSHSAKELYHLIFPSLKSGSETHIHAATLALGHSHLEVCEPMFGELRSFLDEVateTESKPKWKSQKARREELRVHVAN 266

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842  986 IFELLADagvisDSTNGALERDTLaLGALFLEYV-DLTRMLLEA--ENDKEVEILKDIRAhfSAMVANLIQCVPVHHRRF 1062
Cdd:pfam14228  267 IYRMVAE-----NFWPGMLIRKPV-FRLHVLKFIeDTVRYITTSplENFQDLQPLRFALA--SVLRSLAPEFVKSKSERF 338

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1063 lfpQQSLRHHLFILFSQWAGPFSIMFTPlDRYSDRNHQITRY----------------------------QYCALKAMSA 1114
Cdd:pfam14228  339 ---DPRTRKRLFDLLASWCDDTGTVWSQ-DGVSDYRREVERYkssqnsrskdsvdkisfdkevneqveaiQWIAMNAMAA 414

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1115 VLCcGPVFDNVGLSPDGYLYKWLDNI--------------------------------LACQD------LRVHqLGCEVV 1156
Cdd:pfam14228  415 LLY-GPCFDDNARKMSGRVIAWINGLflepaprapfgyspadprtpsyskfagegvrgLGGKDrhrggpLRVH-LAKVAL 492

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1157 MLLLELNPDqinLFNWAIDRCYTGSYQLASGCFKAIATVCGNRNYP-FDIVTLLNLVLFKASDTNREIYEVSMQLMQILE 1235
Cdd:pfam14228  493 KNLLQTNLD---LFPACIDQCYSSDASIADGYFSVLAEVYMRQEIPrCDIQRLLSLILYKVVDPSRRIRDDALQMLETLS 569

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1236 AKLFVHSkkvAEQRPGSILYGTHGPLPPLYSVSLALLSCELARMYPELTLPLFSEVSQR-FPTTHPNGRQIMLTYLLPWL 1314
Cdd:pfam14228  570 VREWAED---GEEGTGRYRAAVVGNLPDSYQQFQYKLSAKLAKDHPELSELLCEEIMQRqLDAVDIIAQHQVLTCMAPWI 646

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1315 HNIELVdsrlllpgsspsspedevkdregevtashGLKGNGWgspeaTSLVLNNLMYMTAKYGDEVPGaEMENAWNALAN 1394
Cdd:pfam14228  647 ENLNFL-----------------------------KLWESGW-----SERLLKSLYYVTWRHGDQFPD-EIEKLWRTIAS 691

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1395 NEKwsnNLRVTLQFLISLCGVSSDT--------ILLPYI---KKVATYLCRNNTIQTMEELLFELQQ------TEPVNPi 1457
Cdd:pfam14228  692 KPR---NISPVLDFLISKGIEDCDSnasaeitgAFATYFsvaKRVSLYLARICPQQTIDHLVYELAQrmleesVEPSRP- 767

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1458 vqhcdnppfyrftasskasAAASGTTSSSNTVVAGQDsfPDPEESKILKESDDRFSNVIrAHTRLESRYSNSSGG----- 1532
Cdd:pfam14228  768 -------------------SDGAFDLESSAVLEFSQG--PAPVQVAQLLDPQPHMSPLL-VRSSLEGPLRNASGSlswrt 825

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1533 SYDEDKNDPISPYTGWLLSITEAKQ-----PQPLPMPCSGGcwaPLV-------------------DYLPET-------- 1580
Cdd:pfam14228  826 VTGRSMSGPLNTMPEVVAVDTHTGRsgqlfTGSGPLPNMSG---PLMgvrsstgslrshhvsrdsgDYFIDTpnsveeir 902

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1581 ITP-----------RGPLH---RCNIAVIFMTEMVVDHSvrEDWALHLPLLLHAVFLGLDHYRPEVFEHSKklllhllia 1646
Cdd:pfam14228  903 ITPvvnaselqsalQGHQHwlsRADIALILLAEIAYEND--EDFRSHLPLLFHVTFVSMDSSEDIVLKHCQ--------- 971

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1647 lscnsnfHAIASVL--LQTREMgeaktltmqpayqpeylytggfdflredqsspvpdsglnssstsssislggssgnlpq 1724
Cdd:pfam14228  972 -------HLLVNLLysLAGRHL---------------------------------------------------------- 986

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413842 1725 mtqEVEDVEAAT-ETDEKASKLIEFLTTRAFGPLWCHEDITPKNQNSKSAEQLSNFLRHVVS--VFKDSrsgfhLEQHLS 1801
Cdd:pfam14228  987 ---ELYDVEHGDgEYKQQVVSLIKYVQSKRGSRMWENEDMTLTRTELPSAALLSALVLSMVDaiFFQGD-----LREKWG 1058

                         1290      1300      1310      1320
                   ....*....|....*....|....*....|....*....|....*..
gi 1720413842 1802 EVALQTALASSSRHYAGRSFQIFRALKQPLSAHALSDLLSRLVEVIG 1848
Cdd:pfam14228 1059 EEALKWAMECTSRHLACRSHQIYRALRPSVTSDTCVSLLRCLHRCLG 1105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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