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Conserved domains on  [gi|1720409630|ref|XP_030109589|]
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zinc finger MYM-type protein 4 isoform X2 [Mus musculus]

Protein Classification

zf-FCS and DUF3504 domain-containing protein( domain architecture ID 10534361)

protein containing domains TRASH, zf-FCS, and DUF3504

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3504 pfam12012
Domain of unknown function (DUF3504); This presumed domain is functionally uncharacterized. ...
 1326-1496 1.67e-87

Domain of unknown function (DUF3504); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 156 to 173 amino acids in length.


:

Pssm-ID: 463430  Cd Length: 162  Bit Score: 281.46  E-value: 1.67e-87
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720409630 1326 MFSRIEEEHLWECKQLGAYSPIVLLNTLLFFNTKYFQLRNVTEHLKLSFAHVMRRTRTLKYsTKMTYLRFFPPlqkpese 1405
Cdd:pfam12012    1 VFSRVEEEHLWECKQLGAHSPIVLLNTLVYFNTKYFNLRTVEEHRRLSFSNVVRHTKPNPR-EKSTYLRYYEP------- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720409630 1406 PDKVTIGKRKRNEDDEAPVgVEMAENTDNPLRCPVRLYEFYLSKCSESVKQRSDVFYLQPERSCVPNSPMWYSTFPIDPG 1485
Cdd:pfam12012   73 PDQVETGGRKKRDEGVNKV-VEQHENSENPLRCPVKLYEFYLSKCPESVKQRKDVFYLQPEPSCVPDSPLWYSSQPLGRN 151

                          170
                   ....*....|.
gi 1720409630 1486 TLDTMLTRILM 1496
Cdd:pfam12012  152 TLESMLTRILL 162
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 450-490 4.83e-07

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


:

Pssm-ID: 428958  Cd Length: 40  Bit Score: 47.37  E-value: 4.83e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1720409630  450 LTMNCCENCGGYCYSGSGQcHVLQIEGQSKKFCSSMCVTSY 490
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTV-IVLQNDGSVGQFCSQSCLDSY 40
TRASH smart00746
metallochaperone-like domain;
358-398 2.38e-05

metallochaperone-like domain;


:

Pssm-ID: 214799  Cd Length: 39  Bit Score: 42.75  E-value: 2.38e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1720409630   358 CSSCSKDILNPKDVISAQFENSTtsKDFCSQSCLSTYELKK 398
Cdd:smart00746    1 CSFCGKDIYNPGTGIMVVNDGKV--YYFCSSKCLSKFKKKR 39
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 305-342 3.37e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


:

Pssm-ID: 428958  Cd Length: 40  Bit Score: 39.66  E-value: 3.37e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1720409630  305 AVRVSCSGCKKILQKGQTAY--QRKGSTQLFCSTLCLTGY 342
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVIvlQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 652-688 7.12e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


:

Pssm-ID: 428958  Cd Length: 40  Bit Score: 38.51  E-value: 7.12e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1720409630  652 VKLRCQHCNRLFATKPEL--LDYKGKMFQFCGKNCCDEY 688
Cdd:pfam06467    2 VKATCWFCKKLIKNKPTVivLQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 694-729 7.93e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


:

Pssm-ID: 428958  Cd Length: 40  Bit Score: 38.51  E-value: 7.93e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1720409630  694 VMAMCEYCKIEKIIKET---VRFSGADKSFCSEGCKLLY 729
Cdd:pfam06467    2 VKATCWFCKKLIKNKPTvivLQNDGSVGQFCSQSCLDSY 40
TRASH smart00746
metallochaperone-like domain;
500-538 6.04e-03

metallochaperone-like domain;


:

Pssm-ID: 214799  Cd Length: 39  Bit Score: 35.82  E-value: 6.04e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1720409630   500 CALCKSLRSSAEMIENTNSLGKTELFCSVNCLSAYRVKM 538
Cdd:smart00746    1 CSFCGKDIYNPGTGIMVVNDGKVYYFCSSKCLSKFKKKR 39
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 741-775 9.31e-03

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


:

Pssm-ID: 428958  Cd Length: 40  Bit Score: 35.42  E-value: 9.31e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720409630  741 CKMCSYC---LQTSPKLIQNNLGGKVEDFCCEECMSKY 775
Cdd:pfam06467    3 KATCWFCkklIKNKPTVIVLQNDGSVGQFCSQSCLDSY 40
 
Name Accession Description Interval E-value
DUF3504 pfam12012
Domain of unknown function (DUF3504); This presumed domain is functionally uncharacterized. ...
 1326-1496 1.67e-87

Domain of unknown function (DUF3504); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 156 to 173 amino acids in length.


Pssm-ID: 463430  Cd Length: 162  Bit Score: 281.46  E-value: 1.67e-87
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720409630 1326 MFSRIEEEHLWECKQLGAYSPIVLLNTLLFFNTKYFQLRNVTEHLKLSFAHVMRRTRTLKYsTKMTYLRFFPPlqkpese 1405
Cdd:pfam12012    1 VFSRVEEEHLWECKQLGAHSPIVLLNTLVYFNTKYFNLRTVEEHRRLSFSNVVRHTKPNPR-EKSTYLRYYEP------- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720409630 1406 PDKVTIGKRKRNEDDEAPVgVEMAENTDNPLRCPVRLYEFYLSKCSESVKQRSDVFYLQPERSCVPNSPMWYSTFPIDPG 1485
Cdd:pfam12012   73 PDQVETGGRKKRDEGVNKV-VEQHENSENPLRCPVKLYEFYLSKCPESVKQRKDVFYLQPEPSCVPDSPLWYSSQPLGRN 151

                          170
                   ....*....|.
gi 1720409630 1486 TLDTMLTRILM 1496
Cdd:pfam12012  152 TLESMLTRILL 162
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 450-490 4.83e-07

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 47.37  E-value: 4.83e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1720409630  450 LTMNCCENCGGYCYSGSGQcHVLQIEGQSKKFCSSMCVTSY 490
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTV-IVLQNDGSVGQFCSQSCLDSY 40
TRASH smart00746
metallochaperone-like domain;
358-398 2.38e-05

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 42.75  E-value: 2.38e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1720409630   358 CSSCSKDILNPKDVISAQFENSTtsKDFCSQSCLSTYELKK 398
Cdd:smart00746    1 CSFCGKDIYNPGTGIMVVNDGKV--YYFCSSKCLSKFKKKR 39
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 353-394 3.84e-05

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 42.36  E-value: 3.84e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1720409630  353 LTKKTCSSCSKDILNPKDVIsaQFENSTTSKDFCSQSCLSTY 394
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVI--VLQNDGSVGQFCSQSCLDSY 40
TRASH smart00746
metallochaperone-like domain;
455-493 1.68e-04

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 40.44  E-value: 1.68e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1720409630   455 CENCGGYCYSGSGQCHVlQIEGQSKKFCSSMCVTSYKQK 493
Cdd:smart00746    1 CSFCGKDIYNPGTGIMV-VNDGKVYYFCSSKCLSKFKKK 38
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 305-342 3.37e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 39.66  E-value: 3.37e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1720409630  305 AVRVSCSGCKKILQKGQTAY--QRKGSTQLFCSTLCLTGY 342
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVIvlQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 652-688 7.12e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 38.51  E-value: 7.12e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1720409630  652 VKLRCQHCNRLFATKPEL--LDYKGKMFQFCGKNCCDEY 688
Cdd:pfam06467    2 VKATCWFCKKLIKNKPTVivLQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 694-729 7.93e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 38.51  E-value: 7.93e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1720409630  694 VMAMCEYCKIEKIIKET---VRFSGADKSFCSEGCKLLY 729
Cdd:pfam06467    2 VKATCWFCKKLIKNKPTvivLQNDGSVGQFCSQSCLDSY 40
TRASH smart00746
metallochaperone-like domain;
500-538 6.04e-03

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 35.82  E-value: 6.04e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1720409630   500 CALCKSLRSSAEMIENTNSLGKTELFCSVNCLSAYRVKM 538
Cdd:smart00746    1 CSFCGKDIYNPGTGIMVVNDGKVYYFCSSKCLSKFKKKR 39
TRASH smart00746
metallochaperone-like domain;
656-692 8.97e-03

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 35.43  E-value: 8.97e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1720409630   656 CQHCNRLF--ATKPELLDYKGKMFQFCGKNCCDEYKKIN 692
Cdd:smart00746    1 CSFCGKDIynPGTGIMVVNDGKVYYFCSSKCLSKFKKKR 39
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 741-775 9.31e-03

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 35.42  E-value: 9.31e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720409630  741 CKMCSYC---LQTSPKLIQNNLGGKVEDFCCEECMSKY 775
Cdd:pfam06467    3 KATCWFCkklIKNKPTVIVLQNDGSVGQFCSQSCLDSY 40
 
Name Accession Description Interval E-value
DUF3504 pfam12012
Domain of unknown function (DUF3504); This presumed domain is functionally uncharacterized. ...
 1326-1496 1.67e-87

Domain of unknown function (DUF3504); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 156 to 173 amino acids in length.


Pssm-ID: 463430  Cd Length: 162  Bit Score: 281.46  E-value: 1.67e-87
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720409630 1326 MFSRIEEEHLWECKQLGAYSPIVLLNTLLFFNTKYFQLRNVTEHLKLSFAHVMRRTRTLKYsTKMTYLRFFPPlqkpese 1405
Cdd:pfam12012    1 VFSRVEEEHLWECKQLGAHSPIVLLNTLVYFNTKYFNLRTVEEHRRLSFSNVVRHTKPNPR-EKSTYLRYYEP------- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720409630 1406 PDKVTIGKRKRNEDDEAPVgVEMAENTDNPLRCPVRLYEFYLSKCSESVKQRSDVFYLQPERSCVPNSPMWYSTFPIDPG 1485
Cdd:pfam12012   73 PDQVETGGRKKRDEGVNKV-VEQHENSENPLRCPVKLYEFYLSKCPESVKQRKDVFYLQPEPSCVPDSPLWYSSQPLGRN 151

                          170
                   ....*....|.
gi 1720409630 1486 TLDTMLTRILM 1496
Cdd:pfam12012  152 TLESMLTRILL 162
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 450-490 4.83e-07

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 47.37  E-value: 4.83e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1720409630  450 LTMNCCENCGGYCYSGSGQcHVLQIEGQSKKFCSSMCVTSY 490
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTV-IVLQNDGSVGQFCSQSCLDSY 40
TRASH smart00746
metallochaperone-like domain;
358-398 2.38e-05

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 42.75  E-value: 2.38e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1720409630   358 CSSCSKDILNPKDVISAQFENSTtsKDFCSQSCLSTYELKK 398
Cdd:smart00746    1 CSFCGKDIYNPGTGIMVVNDGKV--YYFCSSKCLSKFKKKR 39
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 353-394 3.84e-05

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 42.36  E-value: 3.84e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1720409630  353 LTKKTCSSCSKDILNPKDVIsaQFENSTTSKDFCSQSCLSTY 394
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVI--VLQNDGSVGQFCSQSCLDSY 40
TRASH smart00746
metallochaperone-like domain;
455-493 1.68e-04

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 40.44  E-value: 1.68e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1720409630   455 CENCGGYCYSGSGQCHVlQIEGQSKKFCSSMCVTSYKQK 493
Cdd:smart00746    1 CSFCGKDIYNPGTGIMV-VNDGKVYYFCSSKCLSKFKKK 38
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 305-342 3.37e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 39.66  E-value: 3.37e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1720409630  305 AVRVSCSGCKKILQKGQTAY--QRKGSTQLFCSTLCLTGY 342
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVIvlQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 652-688 7.12e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 38.51  E-value: 7.12e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1720409630  652 VKLRCQHCNRLFATKPEL--LDYKGKMFQFCGKNCCDEY 688
Cdd:pfam06467    2 VKATCWFCKKLIKNKPTVivLQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 694-729 7.93e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 38.51  E-value: 7.93e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1720409630  694 VMAMCEYCKIEKIIKET---VRFSGADKSFCSEGCKLLY 729
Cdd:pfam06467    2 VKATCWFCKKLIKNKPTvivLQNDGSVGQFCSQSCLDSY 40
TRASH smart00746
metallochaperone-like domain;
500-538 6.04e-03

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 35.82  E-value: 6.04e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1720409630   500 CALCKSLRSSAEMIENTNSLGKTELFCSVNCLSAYRVKM 538
Cdd:smart00746    1 CSFCGKDIYNPGTGIMVVNDGKVYYFCSSKCLSKFKKKR 39
TRASH smart00746
metallochaperone-like domain;
656-692 8.97e-03

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 35.43  E-value: 8.97e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1720409630   656 CQHCNRLF--ATKPELLDYKGKMFQFCGKNCCDEYKKIN 692
Cdd:smart00746    1 CSFCGKDIynPGTGIMVVNDGKVYYFCSSKCLSKFKKKR 39
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 741-775 9.31e-03

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 35.42  E-value: 9.31e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720409630  741 CKMCSYC---LQTSPKLIQNNLGGKVEDFCCEECMSKY 775
Cdd:pfam06467    3 KATCWFCkklIKNKPTVIVLQNDGSVGQFCSQSCLDSY 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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