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Conserved domains on  [gi|1720354771|ref|XP_030108858|]
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translin isoform X1 [Mus musculus]

Protein Classification

translin family protein( domain architecture ID 1067)

translin (also known as TB-RBP), and its binding partner protein TRAX (translin-associated factor-X) are a paralogous pair of conserved proteins; translin-TRAX complex enhances the removal of the passenger strand in RNAi and the formation of active RISC

Gene Ontology:  GO:0043565
PubMed:  21552261|20578993

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Translin-like super family cl00957
Translin and translin-associated factor-X (TRAX); Translin (also known as TB-RBP), and its ...
 10-126 1.60e-50

Translin and translin-associated factor-X (TRAX); Translin (also known as TB-RBP), and its binding partner protein TRAX (translin-associated factor-X) are a paralogous pair of conserved proteins, and oligomeric complexes of TRAX and translin are known as C3PO proteins (for component 3 promoter of RNA-induced silencing complex or RISC). The Translin-Trax complex enhances the removal of the passenger strand in RNAi and the formation of active RISC. Translin and Trax participate in a variety of nucleic acid metabolism pathways in addition to RNAi and have been implicated in a wide range of biological activities, including mRNA processing, cell growth regulation, spermatogenesis, neuronal development/function, genome stability regulation and carcinogenesis; however, their precise role in some of the processes remains unclear. It has been shown that Trax subunit, but not Translin, possesses a Glu-Glu-Asp catalytic center with the capacity to digest RNA as well as DNA; this catalytic activity is required for passenger-strand removal and RISC activation in RNAi. In Archaeoglobus fulgidus, Trax-like-subunits assemble into an octameric structure, highly similar to human C3PO; its complex with duplex RNA reveals that the octamer entirely encapsulates a single 13-base-pair RNA duplex inside a large inner cavity.


The actual alignment was detected with superfamily member cd14805:

Pssm-ID: 470011 [Multi-domain]  Cd Length: 197  Bit Score: 159.97  E-value: 1.60e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354771  10 LQGFLAAEQDIREEIRKVVQSLEQTAREILTLLQGVHQGTgfQDIPKRCLKAREHFSTVKTHLTSLKTKFPAEQYYRFHE 89
Cdd:cd14805     1 YQGELDAEQDIRERIRKVVRDIEQESKEIIFLLQGIHSGK--GDIEKRCLEAREHLNTVKQKLTSLATELPAEQYYRFHE 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1720354771  90 HWRFVLQRLVFLAAFVVYLETETLVTREAVTEILGIE 126
Cdd:cd14805    79 HWTFGLQRLVFAAAFVVYLETETLVTREEVTEILGIE 115
 
Name Accession Description Interval E-value
Translin-like cd14805
Translin and translin-associated factor-X (TRAX); Translin (also known as TB-RBP), and its ...
 10-126 1.60e-50

Translin and translin-associated factor-X (TRAX); Translin (also known as TB-RBP), and its binding partner protein TRAX (translin-associated factor-X) are a paralogous pair of conserved proteins, and oligomeric complexes of TRAX and translin are known as C3PO proteins (for component 3 promoter of RNA-induced silencing complex or RISC). The Translin-Trax complex enhances the removal of the passenger strand in RNAi and the formation of active RISC. Translin and Trax participate in a variety of nucleic acid metabolism pathways in addition to RNAi and have been implicated in a wide range of biological activities, including mRNA processing, cell growth regulation, spermatogenesis, neuronal development/function, genome stability regulation and carcinogenesis; however, their precise role in some of the processes remains unclear. It has been shown that Trax subunit, but not Translin, possesses a Glu-Glu-Asp catalytic center with the capacity to digest RNA as well as DNA; this catalytic activity is required for passenger-strand removal and RISC activation in RNAi. In Archaeoglobus fulgidus, Trax-like-subunits assemble into an octameric structure, highly similar to human C3PO; its complex with duplex RNA reveals that the octamer entirely encapsulates a single 13-base-pair RNA duplex inside a large inner cavity.


Pssm-ID: 271348 [Multi-domain]  Cd Length: 197  Bit Score: 159.97  E-value: 1.60e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354771  10 LQGFLAAEQDIREEIRKVVQSLEQTAREILTLLQGVHQGTgfQDIPKRCLKAREHFSTVKTHLTSLKTKFPAEQYYRFHE 89
Cdd:cd14805     1 YQGELDAEQDIRERIRKVVRDIEQESKEIIFLLQGIHSGK--GDIEKRCLEAREHLNTVKQKLTSLATELPAEQYYRFHE 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1720354771  90 HWRFVLQRLVFLAAFVVYLETETLVTREAVTEILGIE 126
Cdd:cd14805    79 HWTFGLQRLVFAAAFVVYLETETLVTREEVTEILGIE 115
Translin pfam01997
Translin family; Members of this family include Translin that interacts with DNA and forms a ...
 19-126 8.65e-32

Translin family; Members of this family include Translin that interacts with DNA and forms a ring around the DNA. This family also includes Swiss:Q99598, that was found to interact with translin with yeast two-hybrid screen.


Pssm-ID: 460410 [Multi-domain]  Cd Length: 197  Bit Score: 111.83  E-value: 8.65e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354771  19 DIREEIRKVVQSLEQTAREILTLLQGVHQGTGFQDIpkrCLKAR-EHFSTVKTHLTSLKTKFPAEQYYRFHEHWRFVLQR 97
Cdd:pfam01997   1 DRRERIIKISRDITALSKKIIFLLHRVHSTPSALNV---LNPAKiLAIKEAKERLAELAELLSKLNYYRYNRAWSPGLQE 77

                          90       100
                  ....*....|....*....|....*....
gi 1720354771  98 LVFLAAFVVYLETETLVTREAVTEILGIE 126
Cdd:pfam01997  78 YIEALTFAHYLETGTLLTLEEVQEILGVP 106
 
Name Accession Description Interval E-value
Translin-like cd14805
Translin and translin-associated factor-X (TRAX); Translin (also known as TB-RBP), and its ...
 10-126 1.60e-50

Translin and translin-associated factor-X (TRAX); Translin (also known as TB-RBP), and its binding partner protein TRAX (translin-associated factor-X) are a paralogous pair of conserved proteins, and oligomeric complexes of TRAX and translin are known as C3PO proteins (for component 3 promoter of RNA-induced silencing complex or RISC). The Translin-Trax complex enhances the removal of the passenger strand in RNAi and the formation of active RISC. Translin and Trax participate in a variety of nucleic acid metabolism pathways in addition to RNAi and have been implicated in a wide range of biological activities, including mRNA processing, cell growth regulation, spermatogenesis, neuronal development/function, genome stability regulation and carcinogenesis; however, their precise role in some of the processes remains unclear. It has been shown that Trax subunit, but not Translin, possesses a Glu-Glu-Asp catalytic center with the capacity to digest RNA as well as DNA; this catalytic activity is required for passenger-strand removal and RISC activation in RNAi. In Archaeoglobus fulgidus, Trax-like-subunits assemble into an octameric structure, highly similar to human C3PO; its complex with duplex RNA reveals that the octamer entirely encapsulates a single 13-base-pair RNA duplex inside a large inner cavity.


Pssm-ID: 271348 [Multi-domain]  Cd Length: 197  Bit Score: 159.97  E-value: 1.60e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354771  10 LQGFLAAEQDIREEIRKVVQSLEQTAREILTLLQGVHQGTgfQDIPKRCLKAREHFSTVKTHLTSLKTKFPAEQYYRFHE 89
Cdd:cd14805     1 YQGELDAEQDIRERIRKVVRDIEQESKEIIFLLQGIHSGK--GDIEKRCLEAREHLNTVKQKLTSLATELPAEQYYRFHE 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1720354771  90 HWRFVLQRLVFLAAFVVYLETETLVTREAVTEILGIE 126
Cdd:cd14805    79 HWTFGLQRLVFAAAFVVYLETETLVTREEVTEILGIE 115
Translin cd14819
Translin, also known as TB-RBP (testis brain RNA-binding protein); Translin (also known as ...
 10-126 2.17e-46

Translin, also known as TB-RBP (testis brain RNA-binding protein); Translin (also known as TB-RBP for Testis Brain RNA-binding protein, a mouse ortholog), is a paralog of its binding partner protein TRAX (translin-associated factor-X) and together they form oligomeric complexes known as C3PO proteins (for component 3 promoter of RNA-induced silencing complex or RISC). DNA damage has been proposed to stimulate transport of Translin into nuclei. It binds to RNA and single-stranded DNA, and its selectivity is modulated by interactions with GTP and TRAX. Translin may also regulate dendritic trafficking of BDNF RNAs as well as function as a key activator of siRNA-mediated silencing in drosophila. Translin and Trax participate in a variety of nucleic acid metabolism pathways in addition to RNAi and have been implicated in a wide range of biological activities, including mRNA processing, cell growth regulation, spermatogenesis, neuronal development/function, genome stability regulation and carcinogenesis; however, their precise role in some of the processes remains unclear.


Pssm-ID: 271349  Cd Length: 206  Bit Score: 149.60  E-value: 2.17e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354771  10 LQGFLAAEQDIREEIRKVVQSLEQTAREILTLLQGVHQGTGFQdIPKRCLKAREHFSTVKTHLTSLKTKFPAEQYYRFHE 89
Cdd:cd14819     1 LQEELEKEQELREEIREIVRELDQTLREIQAILQRIHSTPSSQ-VPELCESARELIEEVKETLAELAELIPPHQYYKYND 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1720354771  90 HWRFVLQRLVFLAAFVVYLETETLVTREAVTEILGIE 126
Cdd:cd14819    80 LWRRILQRAVFLIALRHFLETGRLLTLEEVAEILGVP 116
Translin pfam01997
Translin family; Members of this family include Translin that interacts with DNA and forms a ...
 19-126 8.65e-32

Translin family; Members of this family include Translin that interacts with DNA and forms a ring around the DNA. This family also includes Swiss:Q99598, that was found to interact with translin with yeast two-hybrid screen.


Pssm-ID: 460410 [Multi-domain]  Cd Length: 197  Bit Score: 111.83  E-value: 8.65e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354771  19 DIREEIRKVVQSLEQTAREILTLLQGVHQGTGFQDIpkrCLKAR-EHFSTVKTHLTSLKTKFPAEQYYRFHEHWRFVLQR 97
Cdd:pfam01997   1 DRRERIIKISRDITALSKKIIFLLHRVHSTPSALNV---LNPAKiLAIKEAKERLAELAELLSKLNYYRYNRAWSPGLQE 77

                          90       100
                  ....*....|....*....|....*....
gi 1720354771  98 LVFLAAFVVYLETETLVTREAVTEILGIE 126
Cdd:pfam01997  78 YIEALTFAHYLETGTLLTLEEVQEILGVP 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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