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Conserved domains on  [gi|1720404760|ref|XP_030108628|]
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tetratricopeptide repeat protein 14 isoform X4 [Mus musculus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

Gene Ontology:  GO:0005515
PubMed:  10517866|30708253

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
24-188 4.60e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 71.96  E-value: 4.60e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760  24 EDDFASALRKKQSASWALkcVKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALEN 103
Cdd:COG0457    28 IEDYEKALELDPDDAEAL--YNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALEL 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760 104 CPTHRNARKYLCQTLVERgGQLEEeekflnAESYYKKALTLDETFKDA----EDALQKLHKYmQKSLELREKQAEKEEKQ 179
Cdd:COG0457   106 DPDDAEALYNLGLALLEL-GRYDE------AIEAYERALELDPDDADAlynlGIALEKLGRY-EEALELLEKLEAAALAA 177


                  ....*....
gi 1720404760 180 KTKKIETSA 188
Cdd:COG0457   178 LLAAALGEA 186
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
24-188 4.60e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 71.96  E-value: 4.60e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760  24 EDDFASALRKKQSASWALkcVKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALEN 103
Cdd:COG0457    28 IEDYEKALELDPDDAEAL--YNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALEL 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760 104 CPTHRNARKYLCQTLVERgGQLEEeekflnAESYYKKALTLDETFKDA----EDALQKLHKYmQKSLELREKQAEKEEKQ 179
Cdd:COG0457   106 DPDDAEALYNLGLALLEL-GRYDE------AIEAYERALELDPDDADAlynlGIALEKLGRY-EEALELLEKLEAAALAA 177


                  ....*....
gi 1720404760 180 KTKKIETSA 188
Cdd:COG0457   178 LLAAALGEA 186
TPR_11 pfam13414
TPR repeat;
50-88 8.65e-05

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 39.76  E-value: 8.65e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720404760  50 YFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKG 88
Cdd:pfam13414   4 YYEQGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYKLG 42
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 63-144 9.05e-05

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 44.54  E-value: 9.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760  63 YNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHrNARKYLCqtLvergGQLEEEEkflNAESYYKKAL 142
Cdd:cd24142    23 LQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDG-GYEKYLY--L----GQLSGGE---EALQYYEKGI 92


                  ..
gi 1720404760 143 TL 144
Cdd:cd24142    93 EI 94
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 23-164 1.11e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.61  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760  23 SEDDFASALRKKQSASWAlkcvKIGVDYFKV--GRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELA 100
Cdd:TIGR02917 144 AQKSYEQALAIDPRSLYA----KLGLAQLALaeNRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKA 219

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720404760 101 LENCPTHRNARKYLCQTLVERgGQLEEEEKFLNA---------ESYYKKALtLDETFKDAEDALQKLHKYMQK 164
Cdd:TIGR02917 220 IALRPNNIAVLLALATILIEA-GEFEEAEKHADAllkkapnspLAHYLKAL-VDFQKKNYEDARETLQDALKS 290
PRK11447 PRK11447
cellulose synthase subunit BcsC; Provisional
 22-147 4.75e-03

cellulose synthase subunit BcsC; Provisional


Pssm-ID: 183140 [Multi-domain]  Cd Length: 1157  Bit Score: 39.68  E-value: 4.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760   22 FSEDDFASALRK------KQSASWALKCVKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIE 95
Cdd:PRK11447   245 FSDGDSVAAARSqlaeqqKQLADPAFRARAQGLAAVDSGQGGKAIPELQQAVRANPKDSEALGALGQAYSQQGDRARAVA 324

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720404760   96 DFELALENCPTHRNARKY--LCQT-----LVERGGQLEEEEKFLNAESYYKKALTLDET 147
Cdd:PRK11447   325 QFEKALALDPHSSNRDKWesLLKVnrywlLIQQGDAALKANNLAQAERLYQQARQVDNT 383
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
24-188 4.60e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 71.96  E-value: 4.60e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760  24 EDDFASALRKKQSASWALkcVKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALEN 103
Cdd:COG0457    28 IEDYEKALELDPDDAEAL--YNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALEL 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760 104 CPTHRNARKYLCQTLVERgGQLEEeekflnAESYYKKALTLDETFKDA----EDALQKLHKYmQKSLELREKQAEKEEKQ 179
Cdd:COG0457   106 DPDDAEALYNLGLALLEL-GRYDE------AIEAYERALELDPDDADAlynlGIALEKLGRY-EEALELLEKLEAAALAA 177


                  ....*....
gi 1720404760 180 KTKKIETSA 188
Cdd:COG0457   178 LLAAALGEA 186
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 45-170 7.69e-13

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 65.60  E-value: 7.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760  45 KIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERGgq 124
Cdd:COG4783     9 ALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAG-- 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1720404760 125 leeeeKFLNAESYYKKALTLDETFKDAEDALQKLHKYMQKSLELRE 170
Cdd:COG4783    87 -----DYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIA 127
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
46-171 2.94e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.57  E-value: 2.94e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760  46 IGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERgGQL 125
Cdd:COG0457    14 LGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQAL-GRY 92

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720404760 126 EEeekflnAESYYKKALTLDETFKDAED----ALQKLHKYmQKSLELREK 171
Cdd:COG0457    93 EE------ALEDYDKALELDPDDAEALYnlglALLELGRY-DEAIEAYER 135
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
24-173 1.26e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 64.64  E-value: 1.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760  24 EDDFASALRKKQSASWALkcVKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALEN 103
Cdd:COG0457    62 LADYEQALELDPDDAEAL--NNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALEL 139

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760 104 CPTHRNARKYLCQTLVERgGQLEEEEKFLNAESYYKKALTLDETFKDAEDALQKLHKYMQKSLELREKQA 173
Cdd:COG0457   140 DPDDADALYNLGIALEKL-GRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALR 208
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 50-155 1.62e-11

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 61.56  E-value: 1.62e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760  50 YFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLcqtlverGGQLEEEE 129
Cdd:COG4235    27 YLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLL-------GLAAFQQG 99

                          90       100
                  ....*....|....*....|....*.
gi 1720404760 130 KFLNAESYYKKALTLDEtfKDAEDAL 155
Cdd:COG4235   100 DYAEAIAAWQKLLALLP--ADAPARL 123
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 46-151 2.47e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 66.17  E-value: 2.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760  46 IGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLvERGGQL 125
Cdd:COG3914   118 LGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNAL-QDLGRL 196

                          90       100
                  ....*....|....*....|....*.
gi 1720404760 126 EEeekflnAESYYKKALTLDETFKDA 151
Cdd:COG3914   197 EE------AIAAYRRALELDPDNADA 216
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 27-159 4.86e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 63.21  E-value: 4.86e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760  27 FASALRKKQSASWALkcVKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPT 106
Cdd:COG2956    65 HQKLLERDPDRAEAL--LELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPE 142

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720404760 107 HRNArkylcqtLVERGGQLEEEEKFLNAESYYKKALTLDETFKDAEDALQKLH 159
Cdd:COG2956   143 NAHA-------YCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELY 188
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 50-145 6.39e-11

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 60.74  E-value: 6.39e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760  50 YFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERGgqleeee 129
Cdd:COG5010    64 YNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLG------- 136

                          90
                  ....*....|....*.
gi 1720404760 130 KFLNAESYYKKALTLD 145
Cdd:COG5010   137 QDDEAKAALQRALGTS 152
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 24-145 6.97e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 57.12  E-value: 6.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760  24 EDDFASALRKKQSASWALkcVKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALEN 103
Cdd:COG4783    24 EALLEKALELDPDNPEAF--ALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKL 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1720404760 104 CPTHRNARKYLCQTLVERGgqleeeeKFLNAESYYKKALTLD 145
Cdd:COG4783   102 DPEHPEAYLRLARAYRALG-------RPDEAIAALEKALELD 136
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
50-145 7.26e-10

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 55.95  E-value: 7.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760  50 YFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEdFELALENCPTHRNARKYLCQTLVERGgqleeee 129
Cdd:COG3063     2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELG------- 73

                          90
                  ....*....|....*.
gi 1720404760 130 KFLNAESYYKKALTLD 145
Cdd:COG3063    74 DYDEALAYLERALELD 89
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 47-158 8.20e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 59.74  E-value: 8.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760  47 GVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERgGQLE 126
Cdd:COG2956    15 GLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKA-GLLD 93

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1720404760 127 EeekflnAESYYKKALTLDEtfkDAEDALQKL 158
Cdd:COG2956    94 R------AEELLEKLLELDP---DDAEALRLL 116
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 54-173 1.66e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 60.39  E-value: 1.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760  54 GRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERgGQLEEeekfln 133
Cdd:COG3914    92 GRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRL-GRLEE------ 164

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720404760 134 AESYYKKALTLDETFKDAE----DALQKLHKY------MQKSLELREKQA 173
Cdd:COG3914   165 AIAALRRALELDPDNAEALnnlgNALQDLGRLeeaiaaYRRALELDPDNA 214
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
25-169 2.81e-08

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 54.54  E-value: 2.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760  25 DDFASALRKKQSASWALKCVKI----GVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELA 100
Cdd:COG4785    54 AAAALAAERIDRALALPDLAQLyyerGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRA 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760 101 LENCPTHRNARKYLCQTLvERGGQLEEeekflnAESYYKKALTLD-------------ETFKDAEDALQKLHKYMQKSLE 167
Cdd:COG4785   134 LELDPDYAYAYLNRGIAL-YYLGRYEL------AIADLEKALELDpndperalwlylaERKLDPEKALALLLEDWATAYL 206


                  ..
gi 1720404760 168 LR 169
Cdd:COG4785   207 LQ 208
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
24-173 2.50e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.93  E-value: 2.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760  24 EDDFASALRKKQSASWALkcVKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALEN 103
Cdd:COG0457    96 LEDYDKALELDPDDAEAL--YNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAA 173

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760 104 cptHRNARKYLCQTLVERGGQLEEEEKFLNAESYYKKALTLDETFKDAEDALQKLHKYMQKSLELREKQA 173
Cdd:COG0457   174 ---ALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALAL 240
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 24-160 3.12e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 53.07  E-value: 3.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760  24 EDDFASALRKKqsASWALKCVKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALEN 103
Cdd:COG3914   132 LAALRRALALN--PDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALEL 209

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720404760 104 CPTHRNARKYLCQTLVERGGqLEEEEKFLNAESYYKKALTLDETF------KDAEDALQKLHK 160
Cdd:COG3914   210 DPDNADAHSNLLFALRQACD-WEVYDRFEELLAALARGPSELSPFallylpDDDPAELLALAR 271
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
67-173 7.68e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.39  E-value: 7.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760  67 LEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERgGQLEEeekflnAESYYKKALTLDE 146
Cdd:COG0457     1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRL-GRYEE------ALADYEQALELDP 73

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1720404760 147 TFKDA----EDALQKLHKY------MQKSLELREKQA 173
Cdd:COG0457    74 DDAEAlnnlGLALQALGRYeealedYDKALELDPDDA 110
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
24-105 2.16e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 43.24  E-value: 2.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760  24 EDDFASALRKKQSASWALkcVKIGVDYFKVGRHVDAMnEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALEN 103
Cdd:COG3063    12 EEYYEKALELDPDNADAL--NNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALEL 88


                  ..
gi 1720404760 104 CP 105
Cdd:COG3063    89 DP 90
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 58-151 2.30e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 43.84  E-value: 2.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760  58 DAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERGGQLEeeekflnAESY 137
Cdd:COG4235     1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEE-------AEEL 73

                          90
                  ....*....|....
gi 1720404760 138 YKKALTLDETFKDA 151
Cdd:COG4235    74 LERALALDPDNPEA 87
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 16-107 2.76e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 44.03  E-value: 2.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760  16 LYYSKNFSE--DDFASALRKKQSASWALkcVKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKA 93
Cdd:COG4783    48 LLQLGDLDEaiVLLHEALELDPDEPEAR--LNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEA 125

                          90
                  ....*....|....
gi 1720404760  94 IEDFELALENCPTH 107
Cdd:COG4783   126 IAALEKALELDPDD 139
TPR_11 pfam13414
TPR repeat;
50-88 8.65e-05

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 39.76  E-value: 8.65e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720404760  50 YFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKG 88
Cdd:pfam13414   4 YYEQGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYKLG 42
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 63-144 9.05e-05

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 44.54  E-value: 9.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760  63 YNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHrNARKYLCqtLvergGQLEEEEkflNAESYYKKAL 142
Cdd:cd24142    23 LQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDG-GYEKYLY--L----GQLSGGE---EALQYYEKGI 92


                  ..
gi 1720404760 143 TL 144
Cdd:cd24142    93 EI 94
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 46-105 2.01e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.87  E-value: 2.01e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760  46 IGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCP 105
Cdd:COG5010    94 LALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 62-170 4.47e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 40.71  E-value: 4.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760  62 EYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERgGQLEEeekflnAESYYKKA 141
Cdd:COG5010    42 LAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRS-GDKDE------AKEYYEKA 114

                          90       100
                  ....*....|....*....|....*....
gi 1720404760 142 LTLDETFKDAEDALQKLHKYMQKSLELRE 170
Cdd:COG5010   115 LALSPDNPNAYSNLAALLLSLGQDDEAKA 143
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 72-168 1.06e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.40  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760  72 QNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERgGQLEEeekflnAESYYKKALTLDETFKDA 151
Cdd:COG4783     2 ACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQL-GDLDE------AIVLLHEALELDPDEPEA 74

                          90       100
                  ....*....|....*....|....*..
gi 1720404760 152 E----DALQKLHKY------MQKSLEL 168
Cdd:COG4783    75 RlnlgLALLKAGDYdealalLEKALKL 101
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 23-164 1.11e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.61  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760  23 SEDDFASALRKKQSASWAlkcvKIGVDYFKV--GRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELA 100
Cdd:TIGR02917 144 AQKSYEQALAIDPRSLYA----KLGLAQLALaeNRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKA 219

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720404760 101 LENCPTHRNARKYLCQTLVERgGQLEEEEKFLNA---------ESYYKKALtLDETFKDAEDALQKLHKYMQK 164
Cdd:TIGR02917 220 IALRPNNIAVLLALATILIEA-GEFEEAEKHADAllkkapnspLAHYLKAL-VDFQKKNYEDARETLQDALKS 290
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 50-135 4.17e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.94  E-value: 4.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760  50 YFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLcqTLVERGGQLEEEE 129
Cdd:COG2956   188 YLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLALA--DLLERKEGLEAAL 265


                  ....*.
gi 1720404760 130 KFLNAE 135
Cdd:COG2956   266 ALLERQ 271
PRK11447 PRK11447
cellulose synthase subunit BcsC; Provisional
 22-147 4.75e-03

cellulose synthase subunit BcsC; Provisional


Pssm-ID: 183140 [Multi-domain]  Cd Length: 1157  Bit Score: 39.68  E-value: 4.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760   22 FSEDDFASALRK------KQSASWALKCVKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIE 95
Cdd:PRK11447   245 FSDGDSVAAARSqlaeqqKQLADPAFRARAQGLAAVDSGQGGKAIPELQQAVRANPKDSEALGALGQAYSQQGDRARAVA 324

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720404760   96 DFELALENCPTHRNARKY--LCQT-----LVERGGQLEEEEKFLNAESYYKKALTLDET 147
Cdd:PRK11447   325 QFEKALALDPHSSNRDKWesLLKVnrywlLIQQGDAALKANNLAQAERLYQQARQVDNT 383
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 45-107 8.16e-03

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 35.00  E-value: 8.16e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720404760  45 KIGVDYFKVGRHVDAMNEYNKALEIDK---QNVEALVARGALYATKGSLNKAIEDFELALENCPTH 107
Cdd:pfam13432   2 ALARAALRAGDYDDAAAALEAALARFPespDAAAALLLLGLAALRQGRLAEAAAAYRAALRAAPGD 67
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 28-165 8.38e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.91  E-value: 8.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404760  28 ASALRKKQSASWALKcvkiGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTH 107
Cdd:TIGR02917 593 AADAAPDSPEAWLML----GRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPDN 668

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720404760 108 RNARKYLCQTLVErGGQLEEEEKFL------NAESYYKKALTLDETF--KDAEDALQKLHKYMQKS 165
Cdd:TIGR02917 669 TEAQIGLAQLLLA-AKRTESAKKIAkslqkqHPKAALGFELEGDLYLrqKDYPAAIQAYRKALKRA 733
TPR_1 pfam00515
Tetratricopeptide repeat;
74-107 9.98e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 33.93  E-value: 9.98e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1720404760  74 VEALVARGALYATKGSLNKAIEDFELALENCPTH 107
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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