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Conserved domains on  [gi|1720354110|ref|XP_030107955|]
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nuclear receptor coactivator 2 isoform X7 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
bHLH-PAS_NCoA2_SRC2 cd18950
basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 ...
 28-91 6.33e-44

basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins; NCoA-2, also termed Class E basic helix-loop-helix protein 75 (bHLHe75), or transcriptional intermediary factor 2 (TIF2), or steroid receptor coactivator 2 (SRC-2), or glucocorticoid receptor interacting protein-1 (GRIP1), is a bHLH-PAS transcriptional coactivator for steroid receptors and nuclear receptors. It is required with NCoA-1 to control energy balance between white and brown adipose tissues.


:

Pssm-ID: 381520  Cd Length: 64  Bit Score: 153.31  E-value: 6.33e-44
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720354110   28 PSPKRSTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKAAA 91
Cdd:cd18950      1 PSPKRSTEKRNREQENKYIEELAELIFANFNDIDNFNVKPDKCAILKETVKQIRQIKEQEKAAA 64
NCOA_u2 pfam16665
Unstructured region on nuclear receptor coactivator protein; NCOA_u2 is a region of natively ...
 463-587 1.11e-37

Unstructured region on nuclear receptor coactivator protein; NCOA_u2 is a region of natively unstructured but highly conserved sequence found on higher eukaryote nuclear receptor coactivator proteins. It lies between a PAS domain, pfam14598 and a steroid receptor coactivator domain, pfam08832. The function is not known.


:

Pssm-ID: 465223 [Multi-domain]  Cd Length: 119  Bit Score: 137.56  E-value: 1.11e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354110  463 YALKMNSPSQSSPGMNPGQASSVLSPRQRmspgvaGSPRIPPSQFSPAGSLHSPVGV----CSSTGNSHSYTNSSLNALQ 538
Cdd:pfam16665    1 YGLNMNSPPQGSPGMTPPQQNLMMSPRHR------GSPKMPANQFSPGMGLHSPMGSvssgGSGGGGSRTYSSSSLNALQ 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1720354110  539 ALSEGHGVSLGSSLASPDLKMGNLQnspvNMNPPPLSKMGSLDSKDCFG 587
Cdd:pfam16665   75 AISEGVGNSLGSSLTSPVPKQDSSP----NINSTQQKKEGSSDSKSPSS 119
DUF4927 pfam16279
Domain of unknown function (DUF4927); This family, around 80 residues, consists of ...
 731-816 1.02e-35

Domain of unknown function (DUF4927); This family, around 80 residues, consists of uncharacterized and nuclear receptor coactivator 2 proteins and is mainly found in mammalia species. The specific function of this family is still unknown.


:

Pssm-ID: 465083  Cd Length: 87  Bit Score: 130.69  E-value: 1.02e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354110  731 KQEPASPKKKE-NALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPASNTKLIAMKTVKEEVSFEPSDQPGSELDNLEEI 809
Cdd:pfam16279    1 KQEQLSPKKKKnNALLRYLLDKDDSKDPLSKDIKPKLEGLDGKTGPCSSSKIPTSKSEKEESKIKTEPPDELSLDNLDAI 80


                   ....*..
gi 1720354110  810 LDDLQNS 816
Cdd:pfam16279   81 LGDLRNS 87
PAS_11 super family cl37882
PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), ...
 268-378 1.04e-27

PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).


The actual alignment was detected with superfamily member pfam14598:

Pssm-ID: 464214 [Multi-domain]  Cd Length: 110  Bit Score: 108.54  E-value: 1.04e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354110  268 ESFTTRQDLQGKITSLDTstmRAAMKPGWED--LVRRCIQKFHTQHEgesLSYAKRHHHEVL-RQGLAFSQIYRFSLSDG 344
Cdd:pfam14598    2 EQFTTRHDIDGKIISCDT---RAPFSLGYEKdeLVGRSIYDLVHPQD---LRTAKSHLREIIqTRGRATSPSYRLRLRDG 75

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1720354110  345 TLVAAQTKSKLIRSQTTNEPQLVISLHMLHREQN 378
Cdd:pfam14598   76 DFLSVHTKSKLFLNQNSNQQPFIMCTHTILREEN 109
SRC-1 pfam08832
Steroid receptor coactivator; This domain is found in steroid/nuclear receptor coactivators ...
 636-709 4.17e-27

Steroid receptor coactivator; This domain is found in steroid/nuclear receptor coactivators and contains two LXXLL motifs that are involved in receptor binding. The family includes SRC-1/NcoA-1, NcoA-2/TIF2, pCIP/ACTR/GRIP-1/AIB1.


:

Pssm-ID: 462615 [Multi-domain]  Cd Length: 87  Bit Score: 105.94  E-value: 4.17e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354110  636 KGQTKLLQLLTTKSDQMEPSPLPS-SLSDTN-KDSTGSLPGPGST-----------HGTSLKEKHKILHRLLQDSSSPVD 702
Cdd:pfam08832    1 KGHKKLLQLLTTPTEQLGPSPLRShADADTDcKDSLAGVTSPSSGvssssgsscpsHHSSLQEKHKILHRLLQNGNSPDD 80


                   ....*..
gi 1720354110  703 LAKLTAE 709
Cdd:pfam08832   81 VAKLTAE 87
DUF1518 pfam07469
Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually ...
 1210-1267 9.16e-22

Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually found tandemly repeated in the nuclear receptor coactivator family (NCOA1/2/3, also known as the SRC/p160 nuclear receptor coactivator family, which are ligand-dependent transcription factors.


:

Pssm-ID: 462174  Cd Length: 58  Bit Score: 89.83  E-value: 9.16e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720354110 1210 GLPAAMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATTPQSPLMSPRMAHTQSPMM 1267
Cdd:pfam07469    1 GMGGQFGGPRNPQAQPQQFPYPPNYGMSQQPDPAFTSALSPQSPMMSPRMGPSQSPMM 58
Nuc_rec_co-act pfam08815
Nuclear receptor coactivator; This region is found on eukaryotic nuclear receptor coactivators ...
 1002-1046 5.73e-17

Nuclear receptor coactivator; This region is found on eukaryotic nuclear receptor coactivators and forms an alpha helical structure.


:

Pssm-ID: 462608 [Multi-domain]  Cd Length: 47  Bit Score: 75.90  E-value: 5.73e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1720354110 1002 ESPSDEGALLDQLYLALRNFD--GLEEIDRALGIPELVSQSQAVDAE 1046
Cdd:pfam08815    1 EGPSDEGALLDQLVSFLSNTDetGLEEIDRALGIPELVGQGQGLDPD 47
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 118-175 1.05e-08

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


:

Pssm-ID: 214512  Cd Length: 67  Bit Score: 52.79  E-value: 1.05e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720354110   118 MMLEALDGFFFVVNLEGSVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNL 175
Cdd:smart00091    5 AILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEAL 62
 
Name Accession Description Interval E-value
bHLH-PAS_NCoA2_SRC2 cd18950
basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 ...
 28-91 6.33e-44

basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins; NCoA-2, also termed Class E basic helix-loop-helix protein 75 (bHLHe75), or transcriptional intermediary factor 2 (TIF2), or steroid receptor coactivator 2 (SRC-2), or glucocorticoid receptor interacting protein-1 (GRIP1), is a bHLH-PAS transcriptional coactivator for steroid receptors and nuclear receptors. It is required with NCoA-1 to control energy balance between white and brown adipose tissues.


Pssm-ID: 381520  Cd Length: 64  Bit Score: 153.31  E-value: 6.33e-44
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720354110   28 PSPKRSTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKAAA 91
Cdd:cd18950      1 PSPKRSTEKRNREQENKYIEELAELIFANFNDIDNFNVKPDKCAILKETVKQIRQIKEQEKAAA 64
NCOA_u2 pfam16665
Unstructured region on nuclear receptor coactivator protein; NCOA_u2 is a region of natively ...
 463-587 1.11e-37

Unstructured region on nuclear receptor coactivator protein; NCOA_u2 is a region of natively unstructured but highly conserved sequence found on higher eukaryote nuclear receptor coactivator proteins. It lies between a PAS domain, pfam14598 and a steroid receptor coactivator domain, pfam08832. The function is not known.


Pssm-ID: 465223 [Multi-domain]  Cd Length: 119  Bit Score: 137.56  E-value: 1.11e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354110  463 YALKMNSPSQSSPGMNPGQASSVLSPRQRmspgvaGSPRIPPSQFSPAGSLHSPVGV----CSSTGNSHSYTNSSLNALQ 538
Cdd:pfam16665    1 YGLNMNSPPQGSPGMTPPQQNLMMSPRHR------GSPKMPANQFSPGMGLHSPMGSvssgGSGGGGSRTYSSSSLNALQ 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1720354110  539 ALSEGHGVSLGSSLASPDLKMGNLQnspvNMNPPPLSKMGSLDSKDCFG 587
Cdd:pfam16665   75 AISEGVGNSLGSSLTSPVPKQDSSP----NINSTQQKKEGSSDSKSPSS 119
DUF4927 pfam16279
Domain of unknown function (DUF4927); This family, around 80 residues, consists of ...
 731-816 1.02e-35

Domain of unknown function (DUF4927); This family, around 80 residues, consists of uncharacterized and nuclear receptor coactivator 2 proteins and is mainly found in mammalia species. The specific function of this family is still unknown.


Pssm-ID: 465083  Cd Length: 87  Bit Score: 130.69  E-value: 1.02e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354110  731 KQEPASPKKKE-NALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPASNTKLIAMKTVKEEVSFEPSDQPGSELDNLEEI 809
Cdd:pfam16279    1 KQEQLSPKKKKnNALLRYLLDKDDSKDPLSKDIKPKLEGLDGKTGPCSSSKIPTSKSEKEESKIKTEPPDELSLDNLDAI 80


                   ....*..
gi 1720354110  810 LDDLQNS 816
Cdd:pfam16279   81 LGDLRNS 87
PAS_11 pfam14598
PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), ...
 268-378 1.04e-27

PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).


Pssm-ID: 464214 [Multi-domain]  Cd Length: 110  Bit Score: 108.54  E-value: 1.04e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354110  268 ESFTTRQDLQGKITSLDTstmRAAMKPGWED--LVRRCIQKFHTQHEgesLSYAKRHHHEVL-RQGLAFSQIYRFSLSDG 344
Cdd:pfam14598    2 EQFTTRHDIDGKIISCDT---RAPFSLGYEKdeLVGRSIYDLVHPQD---LRTAKSHLREIIqTRGRATSPSYRLRLRDG 75

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1720354110  345 TLVAAQTKSKLIRSQTTNEPQLVISLHMLHREQN 378
Cdd:pfam14598   76 DFLSVHTKSKLFLNQNSNQQPFIMCTHTILREEN 109
SRC-1 pfam08832
Steroid receptor coactivator; This domain is found in steroid/nuclear receptor coactivators ...
 636-709 4.17e-27

Steroid receptor coactivator; This domain is found in steroid/nuclear receptor coactivators and contains two LXXLL motifs that are involved in receptor binding. The family includes SRC-1/NcoA-1, NcoA-2/TIF2, pCIP/ACTR/GRIP-1/AIB1.


Pssm-ID: 462615 [Multi-domain]  Cd Length: 87  Bit Score: 105.94  E-value: 4.17e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354110  636 KGQTKLLQLLTTKSDQMEPSPLPS-SLSDTN-KDSTGSLPGPGST-----------HGTSLKEKHKILHRLLQDSSSPVD 702
Cdd:pfam08832    1 KGHKKLLQLLTTPTEQLGPSPLRShADADTDcKDSLAGVTSPSSGvssssgsscpsHHSSLQEKHKILHRLLQNGNSPDD 80


                   ....*..
gi 1720354110  703 LAKLTAE 709
Cdd:pfam08832   81 VAKLTAE 87
DUF1518 pfam07469
Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually ...
 1210-1267 9.16e-22

Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually found tandemly repeated in the nuclear receptor coactivator family (NCOA1/2/3, also known as the SRC/p160 nuclear receptor coactivator family, which are ligand-dependent transcription factors.


Pssm-ID: 462174  Cd Length: 58  Bit Score: 89.83  E-value: 9.16e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720354110 1210 GLPAAMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATTPQSPLMSPRMAHTQSPMM 1267
Cdd:pfam07469    1 GMGGQFGGPRNPQAQPQQFPYPPNYGMSQQPDPAFTSALSPQSPMMSPRMGPSQSPMM 58
Nuc_rec_co-act pfam08815
Nuclear receptor coactivator; This region is found on eukaryotic nuclear receptor coactivators ...
 1002-1046 5.73e-17

Nuclear receptor coactivator; This region is found on eukaryotic nuclear receptor coactivators and forms an alpha helical structure.


Pssm-ID: 462608 [Multi-domain]  Cd Length: 47  Bit Score: 75.90  E-value: 5.73e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1720354110 1002 ESPSDEGALLDQLYLALRNFD--GLEEIDRALGIPELVSQSQAVDAE 1046
Cdd:pfam08815    1 EGPSDEGALLDQLVSFLSNTDetGLEEIDRALGIPELVGQGQGLDPD 47
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 118-175 1.05e-08

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 52.79  E-value: 1.05e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720354110   118 MMLEALDGFFFVVNLEGSVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNL 175
Cdd:smart00091    5 AILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEAL 62
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 123-213 2.00e-08

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 53.41  E-value: 2.00e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354110  123 LDGFFFVVNLEGSVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHtEFVKNLLPKSMVNGGSWSGEP--PRRSSHTFNC 200
Cdd:cd00130      1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDR-EELRERLENLLSGGEPVTLEVrlRRKDGSVIWV 79

                           90
                   ....*....|...
gi 1720354110  201 RMLVKPLPDSEEE 213
Cdd:cd00130     80 LVSLTPIRDEGGE 92
HLH smart00353
helix loop helix domain;
35-88 3.70e-08

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 51.07  E-value: 3.70e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1720354110    35 EKRNREQENKYIEELAELIFANFNdidnfNFKPDKCAILKETVKQIRQIKEQEK 88
Cdd:smart00353    4 ERRRRRKINEAFDELRSLLPTLPK-----NKKLSKAEILRLAIEYIKSLQEELQ 52
PAS pfam00989
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 119-176 7.54e-06

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://0-doi-org.brum.beds.ac.uk/10.1093/femsre/fuab043).


Pssm-ID: 395786 [Multi-domain]  Cd Length: 113  Bit Score: 46.26  E-value: 7.54e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720354110  119 MLEALDGFFFVVNLEGSVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLL 176
Cdd:pfam00989    6 ILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEEDDAEVAELLR 63
PAS COG2202
PAS domain [Signal transduction mechanisms];
119-213 3.11e-03

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 41.16  E-value: 3.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354110  119 MLEALDGFFFVVNLEGSVVFVSENVTQYLRYNQEELMNKSVySILHVGDHTEFVKNLLPKSMVNGGSWSGEPP--RRSSH 196
Cdd:COG2202     16 LVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTL-RDLLPPEDDDEFLELLRAALAGGGVWRGELRnrRKDGS 94

                           90
                   ....*....|....*..
gi 1720354110  197 TFNCRMLVKPLPDSEEE 213
Cdd:COG2202     95 LFWVELSISPVRDEDGE 111
 
Name Accession Description Interval E-value
bHLH-PAS_NCoA2_SRC2 cd18950
basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 ...
 28-91 6.33e-44

basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins; NCoA-2, also termed Class E basic helix-loop-helix protein 75 (bHLHe75), or transcriptional intermediary factor 2 (TIF2), or steroid receptor coactivator 2 (SRC-2), or glucocorticoid receptor interacting protein-1 (GRIP1), is a bHLH-PAS transcriptional coactivator for steroid receptors and nuclear receptors. It is required with NCoA-1 to control energy balance between white and brown adipose tissues.


Pssm-ID: 381520  Cd Length: 64  Bit Score: 153.31  E-value: 6.33e-44
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720354110   28 PSPKRSTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKAAA 91
Cdd:cd18950      1 PSPKRSTEKRNREQENKYIEELAELIFANFNDIDNFNVKPDKCAILKETVKQIRQIKEQEKAAA 64
NCOA_u2 pfam16665
Unstructured region on nuclear receptor coactivator protein; NCOA_u2 is a region of natively ...
 463-587 1.11e-37

Unstructured region on nuclear receptor coactivator protein; NCOA_u2 is a region of natively unstructured but highly conserved sequence found on higher eukaryote nuclear receptor coactivator proteins. It lies between a PAS domain, pfam14598 and a steroid receptor coactivator domain, pfam08832. The function is not known.


Pssm-ID: 465223 [Multi-domain]  Cd Length: 119  Bit Score: 137.56  E-value: 1.11e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354110  463 YALKMNSPSQSSPGMNPGQASSVLSPRQRmspgvaGSPRIPPSQFSPAGSLHSPVGV----CSSTGNSHSYTNSSLNALQ 538
Cdd:pfam16665    1 YGLNMNSPPQGSPGMTPPQQNLMMSPRHR------GSPKMPANQFSPGMGLHSPMGSvssgGSGGGGSRTYSSSSLNALQ 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1720354110  539 ALSEGHGVSLGSSLASPDLKMGNLQnspvNMNPPPLSKMGSLDSKDCFG 587
Cdd:pfam16665   75 AISEGVGNSLGSSLTSPVPKQDSSP----NINSTQQKKEGSSDSKSPSS 119
DUF4927 pfam16279
Domain of unknown function (DUF4927); This family, around 80 residues, consists of ...
 731-816 1.02e-35

Domain of unknown function (DUF4927); This family, around 80 residues, consists of uncharacterized and nuclear receptor coactivator 2 proteins and is mainly found in mammalia species. The specific function of this family is still unknown.


Pssm-ID: 465083  Cd Length: 87  Bit Score: 130.69  E-value: 1.02e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354110  731 KQEPASPKKKE-NALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPASNTKLIAMKTVKEEVSFEPSDQPGSELDNLEEI 809
Cdd:pfam16279    1 KQEQLSPKKKKnNALLRYLLDKDDSKDPLSKDIKPKLEGLDGKTGPCSSSKIPTSKSEKEESKIKTEPPDELSLDNLDAI 80


                   ....*..
gi 1720354110  810 LDDLQNS 816
Cdd:pfam16279   81 LGDLRNS 87
bHLH-PAS_NCoA3_SRC3 cd18949
basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 3 ...
 30-103 1.16e-34

basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 3 (NCoA-3) and similar proteins; NCoA-3, also termed ACTR, or amplified in breast cancer 1 protein (AIB-1), or CBP-interacting protein (pCIP), or Class E basic helix-loop-helix protein 42 (bHLHe42), or receptor-associated coactivator 3 (RAC-3), or steroid receptor coactivator protein 3 (SRC-3), or thyroid hormone receptor activator molecule 1 (TRAM-1), is a bHLH-PAS steroid/nuclear receptor-associated coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. It also plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin.


Pssm-ID: 381519  Cd Length: 73  Bit Score: 127.08  E-value: 1.16e-34
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720354110   30 PKRSTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKaAAANIDEVQKSDVS 103
Cdd:cd18949      1 LNCSGEKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGK-SSSNDDDVQKADVS 73
bHLH-PAS_SRC cd11439
basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in steroid receptor coactivator ...
 30-87 6.49e-32

basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in steroid receptor coactivator (SRC) family; The SRC family of coactivators includes SRC-1 (NcoA-1/p160), SRC-2(TIF2/GRIP1/NcoA-2) and SRC-3(NcoA-3/pCIP/RAC3/ACTR/pCIP/AIB1/TRAM1), which are critical mediators of steroid receptor action. They contain bHLH-PAS domain at the N-terminal that is followed by receptor interacting domain and C-terminal transcriptional activation domain. SRC coactivators interact with nuclear receptors in a ligand-dependent manner and enhance transcriptional activation by the receptor via histone acetylation/methylation.


Pssm-ID: 381445  Cd Length: 58  Bit Score: 118.68  E-value: 6.49e-32
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720354110   30 PKRSTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQE 87
Cdd:cd11439      1 NKCLNEKRRREQENKYIEELAELISASISDMDSLSVKPDKCAILQETVKQIRQIKEQE 58
PAS_11 pfam14598
PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), ...
 268-378 1.04e-27

PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).


Pssm-ID: 464214 [Multi-domain]  Cd Length: 110  Bit Score: 108.54  E-value: 1.04e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354110  268 ESFTTRQDLQGKITSLDTstmRAAMKPGWED--LVRRCIQKFHTQHEgesLSYAKRHHHEVL-RQGLAFSQIYRFSLSDG 344
Cdd:pfam14598    2 EQFTTRHDIDGKIISCDT---RAPFSLGYEKdeLVGRSIYDLVHPQD---LRTAKSHLREIIqTRGRATSPSYRLRLRDG 75

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1720354110  345 TLVAAQTKSKLIRSQTTNEPQLVISLHMLHREQN 378
Cdd:pfam14598   76 DFLSVHTKSKLFLNQNSNQQPFIMCTHTILREEN 109
SRC-1 pfam08832
Steroid receptor coactivator; This domain is found in steroid/nuclear receptor coactivators ...
 636-709 4.17e-27

Steroid receptor coactivator; This domain is found in steroid/nuclear receptor coactivators and contains two LXXLL motifs that are involved in receptor binding. The family includes SRC-1/NcoA-1, NcoA-2/TIF2, pCIP/ACTR/GRIP-1/AIB1.


Pssm-ID: 462615 [Multi-domain]  Cd Length: 87  Bit Score: 105.94  E-value: 4.17e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354110  636 KGQTKLLQLLTTKSDQMEPSPLPS-SLSDTN-KDSTGSLPGPGST-----------HGTSLKEKHKILHRLLQDSSSPVD 702
Cdd:pfam08832    1 KGHKKLLQLLTTPTEQLGPSPLRShADADTDcKDSLAGVTSPSSGvssssgsscpsHHSSLQEKHKILHRLLQNGNSPDD 80


                   ....*..
gi 1720354110  703 LAKLTAE 709
Cdd:pfam08832   81 VAKLTAE 87
bHLH-PAS_NCoA1_SRC1 cd18948
basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 1 ...
 33-88 8.83e-23

basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 1 (NCoA-1) and similar proteins; NCoA-1, also termed Class E basic helix-loop-helix protein 74 (bHLHe74), or protein Hin-2, or RIP160, or renal carcinoma antigen NY-REN-52, or steroid receptor coactivator 1 (SRC-1), is a bHLH-PAS nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion.


Pssm-ID: 381518  Cd Length: 61  Bit Score: 92.73  E-value: 8.83e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720354110   33 STEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIK--EQEK 88
Cdd:cd18948      4 STEKRRREQENKYLEELAELLSANIGDIDSLSVKPDKCKILKKTVDQIQQMKrlEQEK 61
DUF1518 pfam07469
Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually ...
 1210-1267 9.16e-22

Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually found tandemly repeated in the nuclear receptor coactivator family (NCOA1/2/3, also known as the SRC/p160 nuclear receptor coactivator family, which are ligand-dependent transcription factors.


Pssm-ID: 462174  Cd Length: 58  Bit Score: 89.83  E-value: 9.16e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720354110 1210 GLPAAMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATTPQSPLMSPRMAHTQSPMM 1267
Cdd:pfam07469    1 GMGGQFGGPRNPQAQPQQFPYPPNYGMSQQPDPAFTSALSPQSPMMSPRMGPSQSPMM 58
Nuc_rec_co-act pfam08815
Nuclear receptor coactivator; This region is found on eukaryotic nuclear receptor coactivators ...
 1002-1046 5.73e-17

Nuclear receptor coactivator; This region is found on eukaryotic nuclear receptor coactivators and forms an alpha helical structure.


Pssm-ID: 462608 [Multi-domain]  Cd Length: 47  Bit Score: 75.90  E-value: 5.73e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1720354110 1002 ESPSDEGALLDQLYLALRNFD--GLEEIDRALGIPELVSQSQAVDAE 1046
Cdd:pfam08815    1 EGPSDEGALLDQLVSFLSNTDetGLEEIDRALGIPELVGQGQGLDPD 47
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 118-175 1.05e-08

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 52.79  E-value: 1.05e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720354110   118 MMLEALDGFFFVVNLEGSVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNL 175
Cdd:smart00091    5 AILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEAL 62
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 123-213 2.00e-08

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 53.41  E-value: 2.00e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354110  123 LDGFFFVVNLEGSVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHtEFVKNLLPKSMVNGGSWSGEP--PRRSSHTFNC 200
Cdd:cd00130      1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDR-EELRERLENLLSGGEPVTLEVrlRRKDGSVIWV 79

                           90
                   ....*....|...
gi 1720354110  201 RMLVKPLPDSEEE 213
Cdd:cd00130     80 LVSLTPIRDEGGE 92
HLH smart00353
helix loop helix domain;
35-88 3.70e-08

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 51.07  E-value: 3.70e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1720354110    35 EKRNREQENKYIEELAELIFANFNdidnfNFKPDKCAILKETVKQIRQIKEQEK 88
Cdd:smart00353    4 ERRRRRKINEAFDELRSLLPTLPK-----NKKLSKAEILRLAIEYIKSLQEELQ 52
PAS pfam00989
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 119-176 7.54e-06

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://0-doi-org.brum.beds.ac.uk/10.1093/femsre/fuab043).


Pssm-ID: 395786 [Multi-domain]  Cd Length: 113  Bit Score: 46.26  E-value: 7.54e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720354110  119 MLEALDGFFFVVNLEGSVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLL 176
Cdd:pfam00989    6 ILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEEDDAEVAELLR 63
bHLH_SF cd00083
basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators ...
 35-85 2.11e-04

basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. Members of the bHLH superfamily have two highly conserved and functionally distinct regions. The basic part is at the amino end of the bHLH that may bind DNA to a consensus hexanucleotide sequence known as the E box (CANNTG). Different families of bHLH proteins recognize different E-box consensus sequences. At the carboxyl-terminal end of the region is the HLH region that interacts with other proteins to form homo- and heterodimers. bHLH proteins function as a diverse set of regulatory factors because they recognize different DNA sequences and dimerize with different proteins. The bHLH proteins can be divided to cell-type specific and widely expressed proteins. The cell-type specific members of bHLH superfamily are involved in cell-fate determination and act in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis.


Pssm-ID: 381392 [Multi-domain]  Cd Length: 46  Bit Score: 40.20  E-value: 2.11e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1720354110   35 EKRNREQENKYIEELAELIFANFNdidnfNFKPDKCAILKETVKQIRQIKE 85
Cdd:cd00083      1 ERRRRDKINDAFEELKRLLPELPD-----SKKLSKASILQKAVEYIRELQS 46
bHLHzip_scCBP1 cd11398
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae ...
 35-100 7.58e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae centromere-binding protein 1 (CBP-1) and similar proteins; CBP-1, also termed centromere promoter factor 1 (CPF1), or centromere-binding factor 1 (CBF1), is a bHLHzip protein that is required for chromosome stability and methionine prototrophy. It binds as a homodimer to the centromere DNA elements I (CDEI, GTCACATG) region of the centromere that is required for optimal centromere function.


Pssm-ID: 381404 [Multi-domain]  Cd Length: 89  Bit Score: 40.02  E-value: 7.58e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720354110   35 EKRNREQENKYIEELAELifanfndIDNFNFKPDKCAILKETVKQIRQIKEqekAAAANIDEVQKS 100
Cdd:cd11398     15 ERRRRENINEGINELAAL-------VPGNAREKNKGAILARAVEYIQELQE---TEAKNIEKWTLE 70
PAS COG2202
PAS domain [Signal transduction mechanisms];
119-213 3.11e-03

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 41.16  E-value: 3.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354110  119 MLEALDGFFFVVNLEGSVVFVSENVTQYLRYNQEELMNKSVySILHVGDHTEFVKNLLPKSMVNGGSWSGEPP--RRSSH 196
Cdd:COG2202     16 LVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTL-RDLLPPEDDDEFLELLRAALAGGGVWRGELRnrRKDGS 94

                           90
                   ....*....|....*..
gi 1720354110  197 TFNCRMLVKPLPDSEEE 213
Cdd:COG2202     95 LFWVELSISPVRDEDGE 111
bHLH-PAS_ARNT_like cd11437
basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor ...
 34-84 4.57e-03

basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) family; The ARNT family of bHLH-PAS transcription regulators includes ARNT, ARNT-like proteins (ARNTL and ARNTL2), and Drosophila melanogaster protein cycle. They act as the heterodimeric partner for bHLH-PAS proteins such as aryl hydrocarbon receptor (AhR), hypoxia-inducible factor (HIF), and single-minded (SIM). These bHLH-PAS transcription complexes are involved in transcriptional responses to xenobiotic, hypoxia, and developmental pathways. Heterodimerization of bHLH-PAS proteins with ARNT is mediated by contacts between both the bHLH and the tandem PAS domains. ARNT use bHLH and/or PAS domains to interact with several transcriptional coactivators. It is required for activity of the aryl hydrocarbon (dioxin) receptor. ARNTL, also termed Basic-helix-loop-helix-PAS protein MOP3, or brain and muscle ARNT-like 1 (BMAL1), or Class E basic helix-loop-helix protein 5 (bHLHe5), or member of PAS protein 3, or PAS domain-containing protein 3 (PASD3), or bHLH-PAS protein JAP3, is a member of the bHLH-PAS transcription factor family that forms heterodimers with another bHLH-PAS protein, CLOCK (circadian locomotor output cycle kaput), which regulates circadian rhythm. ARNTL-CLOCK heterodimer complex activates transcription from E-box (CANNTG) elements found in the promoter of circadian responsive genes. ARNTL is highly homologous to ARNT. ARNTL2, also termed Basic-helix-loop-helix-PAS protein MOP9, or brain and muscle ARNT-like 2 (BMAL2), or CYCLE-like factor (CLIF), or Class E basic helix-loop-helix protein 6 (bHLHe6), or member of PAS protein 9, or PAS domain-containing protein 9 (PASD9), is a neuronal bHLH-PAS transcriptional factor, regulating cell cycle progression and preventing cell death, whose sustained expression might ensure brain neuron survival. It also plays important roles in tumor angiogenesis. Protein cycle, also termed brain and muscle ARNT-like 1 (BMAL1), or MOP3, is a putative bHLH-PAS transcription factor involved in the generation of biological rhythms in Drosophila. It activates cycling transcription of Period (PER) and Timeless (TIM) by binding to the E-box (5'-CACGTG-3') present in their promoters.


Pssm-ID: 381443  Cd Length: 58  Bit Score: 36.63  E-value: 4.57e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1720354110   34 TEKRNREQENKYIEELAELIFANFndidNFNFKPDKCAILKETVKQIRQIK 84
Cdd:cd11437      8 IEKRRRDKMNAYIQELSALVPACN----AMSRKLDKLTVLRMAVQHLKSLR 54
bHLHzip_USF_MITF cd11387
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream ...
 35-86 5.03e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream stimulatory factor)/MITF (microphthalmia-associated transcription factor) family includes two bHLHzip transcription factor subfamilies. USFs are ubiquitously expressed and key regulators of a wide number of gene regulation networks, including the stress and immune responses, cell cycle and proliferation, lipid and glucid metabolism. USFs recruit chromatin remodeling enzymes and interact with co-activators and the members of the transcription pre-initiation complex. USFs interact with high affinity to E-box regulatory elements. The MITF (also known as microphthalmia-TFE, or MiT) subfamily comprises four genes in mammals (MITF, TFE3, TFEB, and TFEC); each gene has different functions. MITF is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. TFEB is required for vascularization of the mouse placenta. TFE3 is involved in B cell function. TFEC regulates gene expression in macrophages. The MITF subfamily proteins can form homodimers or heterodimers with each other but not with other bHLH or bHLHzip proteins.


Pssm-ID: 381393 [Multi-domain]  Cd Length: 58  Bit Score: 36.46  E-value: 5.03e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1720354110   35 EKRNREQENKYIEELAELI-FANFNDIDnfnFKPDKCAILKETVKQIRQIKEQ 86
Cdd:cd11387      6 ERRRRDNINEKIQELGSLVpPSRLETKD---LKPNKGSILSKAVEYIRELQNQ 55
bHLH_PAS cd11391
basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain family; bHLH-PAS domain has been found ...
 31-81 6.34e-03

basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain family; bHLH-PAS domain has been found in a large group of bHLH transcription regulators that are involved in gene expression responding to environmental change and controlling aspects of neural development, including proteins from aryl hydrocarbon receptor nuclear translocator (ARNT) family, hypoxia-inducible factor (HIF) family, aryl hydrocarbon receptor (AhR) family, neuronal PAS domain-containing protein (NPAS) family, Circadian locomotor output cycles protein kaput (CLOCK)-like family, and single-minded (SIM) family. bHLH-PAS transcriptional regulatory factors have a bHLH DNA-binding domain followed by two PAS domains and a C-terminal activation or repression domain. bHLH-PAS family members can be divided into class I and class II based on their dimerization partner. bHLH-PAS class I factors include AhR, HIF and SIM. The best characterized bHLH-PAS Class II protein is the ubiquitous ARNT. Some members of bHLH-PAS family act as transcriptional coactivators (such as NCoA) that lack the ability to dimerize and bind DNA.


Pssm-ID: 381397 [Multi-domain]  Cd Length: 55  Bit Score: 36.40  E-value: 6.34e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1720354110   31 KRSTEKRNREQENKYIEELAELIFANFNDIDnfnfKPDKCAILKETVKQIR 81
Cdd:cd11391      4 SREAAKKRRDKENAEISELASLLPLPPAVGS----KLDKLSVLRLAVAYLR 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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