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Conserved domains on  [gi|1720353897|ref|XP_030107539|]
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eukaryotic translation initiation factor 2D isoform X10 [Mus musculus]

Protein Classification

eIF2D_C domain-containing protein( domain architecture ID 10184234)

eIF2D_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
eIF2D_C cd11608
C-terminal domain of eIF2D and related proteins; eIF2D translation initiation factor (also ...
 227-299 3.87e-29

C-terminal domain of eIF2D and related proteins; eIF2D translation initiation factor (also known as ligatin) is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


:

Pssm-ID: 211321  Cd Length: 85  Bit Score: 106.49  E-value: 3.87e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720353897 227 PIDITLALKTYNKKVTVVRNLETYGLDPCSVAAILQQRCQASTIVSPAPGAKDSLQVQVQGNQIHHLGQLLLE 299
Cdd:cd11608     1 PIDITTERRQGNKKVTLISGLESFGIDPEEFAKELQKKCAASTSVSPLPGKKKGVEVQVQGNQVKFVAKLLTE 73
 
Name Accession Description Interval E-value
eIF2D_C cd11608
C-terminal domain of eIF2D and related proteins; eIF2D translation initiation factor (also ...
 227-299 3.87e-29

C-terminal domain of eIF2D and related proteins; eIF2D translation initiation factor (also known as ligatin) is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


Pssm-ID: 211321  Cd Length: 85  Bit Score: 106.49  E-value: 3.87e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720353897 227 PIDITLALKTYNKKVTVVRNLETYGLDPCSVAAILQQRCQASTIVSPAPGAKDSLQVQVQGNQIHHLGQLLLE 299
Cdd:cd11608     1 PIDITTERRQGNKKVTLISGLESFGIDPEEFAKELQKKCAASTSVSPLPGKKKGVEVQVQGNQVKFVAKLLTE 73
SUI1 pfam01253
Translation initiation factor SUI1;
227-299 5.87e-15

Translation initiation factor SUI1;


Pssm-ID: 460137  Cd Length: 75  Bit Score: 68.62  E-value: 5.87e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720353897 227 PIDITLALKTYNKKVTVVRNLETYGLDPCSVAAILQQRCQASTIVSPAPGAKdslQVQVQGNQIHHLGQLLLE 299
Cdd:pfam01253   3 KIHIRVEQRGGRKTVTTVSGLEPFGIDLKKLAKELKKKFACGGTVVKDGGGE---EIQVQGDQRDKVAELLTE 72
 
Name Accession Description Interval E-value
eIF2D_C cd11608
C-terminal domain of eIF2D and related proteins; eIF2D translation initiation factor (also ...
 227-299 3.87e-29

C-terminal domain of eIF2D and related proteins; eIF2D translation initiation factor (also known as ligatin) is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


Pssm-ID: 211321  Cd Length: 85  Bit Score: 106.49  E-value: 3.87e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720353897 227 PIDITLALKTYNKKVTVVRNLETYGLDPCSVAAILQQRCQASTIVSPAPGAKDSLQVQVQGNQIHHLGQLLLE 299
Cdd:cd11608     1 PIDITTERRQGNKKVTLISGLESFGIDPEEFAKELQKKCAASTSVSPLPGKKKGVEVQVQGNQVKFVAKLLTE 73
SUI1 pfam01253
Translation initiation factor SUI1;
227-299 5.87e-15

Translation initiation factor SUI1;


Pssm-ID: 460137  Cd Length: 75  Bit Score: 68.62  E-value: 5.87e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720353897 227 PIDITLALKTYNKKVTVVRNLETYGLDPCSVAAILQQRCQASTIVSPAPGAKdslQVQVQGNQIHHLGQLLLE 299
Cdd:pfam01253   3 KIHIRVEQRGGRKTVTTVSGLEPFGIDLKKLAKELKKKFACGGTVVKDGGGE---EIQVQGDQRDKVAELLTE 72
DENR_C cd11607
C-terminal domain of DENR and related proteins; DENR (density regulated protein), together ...
 230-302 6.88e-05

C-terminal domain of DENR and related proteins; DENR (density regulated protein), together with MCT-1 (multiple copies T cell malignancies), has been shown to have similar function as eIF2D translation initiation factor (also known as ligatin), which is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


Pssm-ID: 211320  Cd Length: 86  Bit Score: 40.62  E-value: 6.88e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720353897 230 ITLALKTYNKK--VTVVRNLETYGLDPCSVAAILQQR--CQAStiVSPAPGAKDslQVQVQGNQIHHLGQLLLEiMW 302
Cdd:cd11607     3 VTIKRISRNKRkfVTTVTGLETFGIDLKKAAKLFAKKfaCGAS--VTKGAEGKD--EIVIQGDVTDDIVDLILE-KW 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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