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Conserved domains on  [gi|1720436461|ref|XP_030107425|]
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histone demethylase UTY isoform X15 [Mus musculus]

Protein Classification

KDM6 family histone demethylase( domain architecture ID 11421451)

KDM6 family histone demethylase, similar to lysine-specific demethylase 6A (KDM6A), also called UTX (ubiquitously-transcribed TPR protein on the X chromosome) that specifically demethylates 'Lys-27' of histone H3, and UTY (ubiquitously-transcribed TPR protein on the Y chromosome) that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3

CATH:  1.25.40.10|2.60.120.10
EC:  1.14.11.-
Gene Ontology:  GO:0005515|GO:0032452|GO:0031490|GO:0046872
PubMed:  26059336|21153002|10517866|30708253|22404999|11165500|14697267|19478949
SCOP:  4001344|3001825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
JmjC pfam02373
JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain ...
 882-990 1.01e-33

JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation.


:

Pssm-ID: 396791  Cd Length: 114  Bit Score: 125.49  E-value: 1.01e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  882 QLCMKVPGSRIPGHQENNNFCSVNINIGPGDCEWFVVPEDYWGVLNDFCEKNN-------LNFLMSSWWPnlEDLYEANV 954
Cdd:pfam02373    1 WLYLGMPFSTTPWHIEDQGLYSINYLHFGAPKVWYIIPPEYAEKFEKVLSDHFggeqpddLLHLNTIISP--KQLRENGI 78

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1720436461  955 PVYRFIQRPGDLVWINAGTVHWVQAIGWCNNITWNV 990
Cdd:pfam02373   79 PVYRFVQKPGEFVFTFPGWYHQVFNLGFNIAEAVNF 114
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
137-374 1.88e-24

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 103.55  E-value: 1.88e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  137 VEIQFHIAHLYETQRKYHSAKAAYEQLLQIEslPSQVKAtvLQQLGWMHHNMdligdnttkERY--AIQYLQKSLEEDPN 214
Cdd:COG0457      8 AEAYNNLGLAYRRLGRYEEAIEDYEKALELD--PDDAEA--LYNLGLAYLRL---------GRYeeALADYEQALELDPD 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  215 SGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGILY 294
Cdd:COG0457     75 DAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIAL 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  295 ESCNQPQDAIKCYlNAARSKSCNNTSALTSRIKFLQAQLCNLPQSSLQNKTKLLPSIEEAWSLPIPAELTSRQGAMNTAQ 374
Cdd:COG0457    155 EKLGRYEEALELL-EKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLAL 233
JmjC smart00558
A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of ...
 848-912 4.48e-04

A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).


:

Pssm-ID: 214721  Cd Length: 58  Bit Score: 39.16  E-value: 4.48e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720436461   848 QLHELTKLPafvrvvSAGNLLSHVGYTILGMNSVQLC-MKVPGSRIPGHQENNNfcSVNINIGPGD 912
Cdd:smart00558    1 QLWNLAKLP------FKLNLLSDLPEDIPGPDVGPYLyMGMAGSTTPWHIDDYD--LVNYLHQGAG 58
 
Name Accession Description Interval E-value
JmjC pfam02373
JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain ...
 882-990 1.01e-33

JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation.


Pssm-ID: 396791  Cd Length: 114  Bit Score: 125.49  E-value: 1.01e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  882 QLCMKVPGSRIPGHQENNNFCSVNINIGPGDCEWFVVPEDYWGVLNDFCEKNN-------LNFLMSSWWPnlEDLYEANV 954
Cdd:pfam02373    1 WLYLGMPFSTTPWHIEDQGLYSINYLHFGAPKVWYIIPPEYAEKFEKVLSDHFggeqpddLLHLNTIISP--KQLRENGI 78

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1720436461  955 PVYRFIQRPGDLVWINAGTVHWVQAIGWCNNITWNV 990
Cdd:pfam02373   79 PVYRFVQKPGEFVFTFPGWYHQVFNLGFNIAEAVNF 114
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
137-374 1.88e-24

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 103.55  E-value: 1.88e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  137 VEIQFHIAHLYETQRKYHSAKAAYEQLLQIEslPSQVKAtvLQQLGWMHHNMdligdnttkERY--AIQYLQKSLEEDPN 214
Cdd:COG0457      8 AEAYNNLGLAYRRLGRYEEAIEDYEKALELD--PDDAEA--LYNLGLAYLRL---------GRYeeALADYEQALELDPD 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  215 SGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGILY 294
Cdd:COG0457     75 DAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIAL 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  295 ESCNQPQDAIKCYlNAARSKSCNNTSALTSRIKFLQAQLCNLPQSSLQNKTKLLPSIEEAWSLPIPAELTSRQGAMNTAQ 374
Cdd:COG0457    155 EKLGRYEEALELL-EKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLAL 233
JmjC smart00558
A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of ...
 848-912 4.48e-04

A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).


Pssm-ID: 214721  Cd Length: 58  Bit Score: 39.16  E-value: 4.48e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720436461   848 QLHELTKLPafvrvvSAGNLLSHVGYTILGMNSVQLC-MKVPGSRIPGHQENNNfcSVNINIGPGD 912
Cdd:smart00558    1 QLWNLAKLP------FKLNLLSDLPEDIPGPDVGPYLyMGMAGSTTPWHIDDYD--LVNYLHQGAG 58
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 139-307 7.22e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.92  E-value: 7.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  139 IQFHIAHLYETQRKYHSAKAAYEQLLQIEslPSQVKATVLQQlgwmhhNMDLIGDNTTKeryAIQYLQKSLEEDPNSGQS 218
Cdd:TIGR02917  467 LHNLLGAIYLGKGDLAKAREAFEKALSIE--PDFFPAAANLA------RIDIQEGNPDD---AIQRFEKVLTIDPKNLRA 535

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  219 WYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGILYESCN 298
Cdd:TIGR02917  536 ILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAG 615


                   ....*....
gi 1720436461  299 QPQDAIKCY 307
Cdd:TIGR02917  616 DLNKAVSSF 624
 
Name Accession Description Interval E-value
JmjC pfam02373
JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain ...
 882-990 1.01e-33

JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation.


Pssm-ID: 396791  Cd Length: 114  Bit Score: 125.49  E-value: 1.01e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  882 QLCMKVPGSRIPGHQENNNFCSVNINIGPGDCEWFVVPEDYWGVLNDFCEKNN-------LNFLMSSWWPnlEDLYEANV 954
Cdd:pfam02373    1 WLYLGMPFSTTPWHIEDQGLYSINYLHFGAPKVWYIIPPEYAEKFEKVLSDHFggeqpddLLHLNTIISP--KQLRENGI 78

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1720436461  955 PVYRFIQRPGDLVWINAGTVHWVQAIGWCNNITWNV 990
Cdd:pfam02373   79 PVYRFVQKPGEFVFTFPGWYHQVFNLGFNIAEAVNF 114
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
137-374 1.88e-24

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 103.55  E-value: 1.88e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  137 VEIQFHIAHLYETQRKYHSAKAAYEQLLQIEslPSQVKAtvLQQLGWMHHNMdligdnttkERY--AIQYLQKSLEEDPN 214
Cdd:COG0457      8 AEAYNNLGLAYRRLGRYEEAIEDYEKALELD--PDDAEA--LYNLGLAYLRL---------GRYeeALADYEQALELDPD 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  215 SGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGILY 294
Cdd:COG0457     75 DAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIAL 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  295 ESCNQPQDAIKCYlNAARSKSCNNTSALTSRIKFLQAQLCNLPQSSLQNKTKLLPSIEEAWSLPIPAELTSRQGAMNTAQ 374
Cdd:COG0457    155 EKLGRYEEALELL-EKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLAL 233
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 90-379 2.42e-22

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 98.26  E-value: 2.42e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461   90 QLGHFNLLLEDYSKALSSYQRYYSLQTDYwkhfqlalidcnvctlssVEIQFHIAHLYETQRKYHSAKAAYEQLLQIEsl 169
Cdd:COG2956     13 FKGLNYLLNGQPDKAIDLLEEALELDPET------------------VEAHLALGNLYRRRGEYDRAIRIHQKLLERD-- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  170 psQVKATVLQQLGWMHHNMDLigdnttKERyAIQYLQKSLEEDPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEAS 249
Cdd:COG2956     73 --PDRAEALLELAQDYLKAGL------LDR-AEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPEN 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  250 ADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGILYESCNQPQDAIKCYLNAARSKScNNTSALtSRIKFL 329
Cdd:COG2956    144 AHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDP-DYLPAL-PRLAEL 221

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1720436461  330 QAQLCNLPQ--SSLQNKTKLLPSIEEAWSLpipAELTSRQGAMNTAQQSVSD 379
Cdd:COG2956    222 YEKLGDPEEalELLRKALELDPSDDLLLAL---ADLLERKEGLEAALALLER 270
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 201-307 2.88e-19

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 85.06  E-value: 2.88e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  201 AIQYLQKSLEEDPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 280
Cdd:COG4235      2 AIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALD 81

                           90       100
                   ....*....|....*....|....*..
gi 1720436461  281 HGHAAAWMDLGILYESCNQPQDAIKCY 307
Cdd:COG4235     82 PDNPEALYLLGLAAFQQGDYAEAIAAW 108
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
209-310 2.77e-18

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 85.83  E-value: 2.77e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  209 LEEDPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWM 288
Cdd:COG0457      1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALN 80

                           90       100
                   ....*....|....*....|..
gi 1720436461  289 DLGILYESCNQPQDAIKCYLNA 310
Cdd:COG0457     81 NLGLALQALGRYEEALEDYDKA 102
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
91-273 7.55e-18

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 84.29  E-value: 7.55e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461   91 LGHFNLLLEDYSKALSSYQRYYSLQTDYWkhfqlalidcnvctlssvEIQFHIAHLYETQRKYHSAKAAYEQLLQIEslP 170
Cdd:COG0457     14 LGLAYRRLGRYEEAIEDYEKALELDPDDA------------------EALYNLGLAYLRLGRYEEALADYEQALELD--P 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  171 SQvkATVLQQLGWMHHNMdligdnttkERY--AIQYLQKSLEEDPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEA 248
Cdd:COG0457     74 DD--AEALNNLGLALQAL---------GRYeeALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPD 142

                          170       180
                   ....*....|....*....|....*
gi 1720436461  249 SADTWCSIGVLYQQQNQPMDALQAY 273
Cdd:COG0457    143 DADALYNLGIALEKLGRYEEALELL 167
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 201-356 3.93e-17

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 86.59  E-value: 3.93e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  201 AIQYLQKSLEEDPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 280
Cdd:COG3914     97 ALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELD 176

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720436461  281 HGHAAAWMDLGILYESCNQPQDAIKCYLNAARsKSCNNTSALTSRIkFLQAQLCNLPQSS-LQNKTKLLPSIEEAWS 356
Cdd:COG3914    177 PDNAEALNNLGNALQDLGRLEEAIAAYRRALE-LDPDNADAHSNLL-FALRQACDWEVYDrFEELLAALARGPSELS 251
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 201-312 2.60e-15

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 74.07  E-value: 2.60e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  201 AIQYLQKSLEEDPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 280
Cdd:COG4783     23 AEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLD 102

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1720436461  281 HGHAAAWMDLGILYESCNQPQDAIKCYLNAAR 312
Cdd:COG4783    103 PEHPEAYLRLARAYRALGRPDEAIAALEKALE 134
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 230-361 2.05e-14

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 77.73  E-value: 2.05e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  230 GKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGILYESCNQPQDAIKCYLN 309
Cdd:COG3914     92 GRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRR 171

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1720436461  310 AARSKScNNTSALTSRIKFLQaQLCNLPQS--SLQNKTKLLPSIEEAWSLPIPA 361
Cdd:COG3914    172 ALELDP-DNAEALNNLGNALQ-DLGRLEEAiaAYRRALELDPDNADAHSNLLFA 223
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
65-251 6.42e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 72.73  E-value: 6.42e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461   65 LNKAIHFYESLIVKAEGKVESdfFCQLGHFNLLLEDYSKALSSYQRYYSLQTDYwkhfqlalidcnvctlssVEIQFHIA 144
Cdd:COG0457     24 YEEAIEDYEKALELDPDDAEA--LYNLGLAYLRLGRYEEALADYEQALELDPDD------------------AEALNNLG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  145 HLYETQRKYHSAKAAYEQLLQIEslPSQVKAtvLQQLGWMHHNMdligdnttkERY--AIQYLQKSLEEDPNSGQSWYFL 222
Cdd:COG0457     84 LALQALGRYEEALEDYDKALELD--PDDAEA--LYNLGLALLEL---------GRYdeAIEAYERALELDPDDADALYNL 150

                          170       180
                   ....*....|....*....|....*....
gi 1720436461  223 GRCYSCIGKVQDAFVSYRQSIDKSEASAD 251
Cdd:COG0457    151 GIALEKLGRYEEALELLEKLEAAALAALL 179
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 137-280 6.89e-13

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 67.14  E-value: 6.89e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  137 VEIQFHIAHLYETQRKYHSAKAAYEQLLQIEslPSQVKAtvLQQLGWMHHNMDligdnttKERYAIQYLQKSLEEDPNSG 216
Cdd:COG4783      4 AEALYALAQALLLAGDYDEAEALLEKALELD--PDNPEA--FALLGEILLQLG-------DLDEAIVLLHEALELDPDEP 72

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720436461  217 QSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 280
Cdd:COG4783     73 EARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELD 136
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 217-312 4.69e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 55.97  E-value: 4.69e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  217 QSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGILYES 296
Cdd:COG4783      5 EALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLK 84

                           90
                   ....*....|....*.
gi 1720436461  297 CNQPQDAIKCYLNAAR 312
Cdd:COG4783     85 AGDYDEALALLEKALK 100
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
201-280 5.39e-09

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 54.41  E-value: 5.39e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  201 AIQYLQKSLEEDPNSGQSWYFLGRCYSCIGKVQDAfVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 280
Cdd:COG3063     11 AEEYYEKALELDPDNADALNNLGLLLLEQGRYDEA-IALEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELD 89
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
212-305 6.92e-09

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 57.62  E-value: 6.92e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  212 DPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLG 291
Cdd:COG4785     69 LPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRG 148

                           90
                   ....*....|....
gi 1720436461  292 ILYESCNQPQDAIK 305
Cdd:COG4785    149 IALYYLGRYELAIA 162
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 201-280 8.46e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 55.74  E-value: 8.46e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  201 AIQYLQKSLEEDPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 280
Cdd:COG5010     73 SLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTS 152
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 218-332 1.09e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.82  E-value: 1.09e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  218 SWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGILYESC 297
Cdd:COG2956     10 GWYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKA 89

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1720436461  298 NQPQDAIKCYLNAARSKScNNTSALTSRIKFLQAQ 332
Cdd:COG2956     90 GLLDRAEELLEKLLELDP-DDAEALRLLAEIYEQE 123
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 201-313 1.56e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 54.97  E-value: 1.56e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  201 AIQYLQKSLEEDPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 280
Cdd:COG5010     39 EDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALS 118

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1720436461  281 HGHAAAWMDLGILYESCNQPQDAIKCYLNAARS 313
Cdd:COG5010    119 PDNPNAYSNLAALLLSLGQDDEAKAALQRALGT 151
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 98-307 3.37e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 57.70  E-value: 3.37e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461   98 LEDYSKALSSYQRYYSLQTDYwkhfqlalidcnvctlssVEIQFHIAHLYETQRKYHSAKAAYEQLLQIEslPSQVKAtv 177
Cdd:COG3914     91 LGRYEEALALYRRALALNPDN------------------AEALFNLGNLLLALGRLEEALAALRRALALN--PDFAEA-- 148

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  178 LQQLGWMHHNMDLIGDnttkeryAIQYLQKSLEEDPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKsEASADTWCSIG 257
Cdd:COG3914    149 YLNLGEALRRLGRLEE-------AIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALEL-DPDNADAHSNL 220

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1720436461  258 VLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGILYESCNQPQDAIKCY 307
Cdd:COG3914    221 LFALRQACDWEVYDRFEELLAALARGPSELSPFALLYLPDDDPAELLALA 270
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 136-251 8.37e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 52.32  E-value: 8.37e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  136 SVEIQFHIAHLYETQRKYHSAKAAYEQLLQIEslPSqvKATVLQQLGWMHHNMDligdNTTKeryAIQYLQKSLEEDPNS 215
Cdd:COG4235     16 DAEGWLLLGRAYLRLGRYDEALAAYEKALRLD--PD--NADALLDLAEALLAAG----DTEE---AEELLERALALDPDN 84

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1720436461  216 GQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASAD 251
Cdd:COG4235     85 PEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAP 120
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 90-246 2.44e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 50.96  E-value: 2.44e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461   90 QLGHFNLLLEDYSKALSSYQRYYSLQTDywkhfqlalidcnvctlsSVEIQFHIAHLYETQRKYHSAKAAYEQLLQIEsl 169
Cdd:COG4783      9 ALAQALLLAGDYDEAEALLEKALELDPD------------------NPEAFALLGEILLQLGDLDEAIVLLHEALELD-- 68

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720436461  170 PSQVKAtvLQQLGWMHHNMDLIGDnttkeryAIQYLQKSLEEDPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKS 246
Cdd:COG4783     69 PDEPEA--RLNLGLALLKAGDYDE-------ALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELD 136
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
230-312 3.50e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 49.40  E-value: 3.50e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  230 GKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQaYICAVQLDHGHAAAWMDLGILYESCNQPQDAIKCYLN 309
Cdd:COG3063      6 GDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEALAYLER 84


                   ...
gi 1720436461  310 AAR 312
Cdd:COG3063     85 ALE 87
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 66-245 1.37e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 51.27  E-value: 1.37e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461   66 NKAIHFYESLIvkAEGKVESDFFCQLGHFNLLLEDYSKALSSYQRyySLQTDYwkhfqlalidcnvctlSSVEIQFHIAH 145
Cdd:COG2956    127 EKAIEVLERLL--KLGPENAHAYCELAELYLEQGDYDEAIEALEK--ALKLDP----------------DCARALLLLAE 186

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  146 LYETQRKYHSAKAAYEQLLQIEslPSQVKAtvLQQLGWMHHNMDLIGDnttkeryAIQYLQKSLEEDPNSGQsWYFLGRC 225
Cdd:COG2956    187 LYLEQGDYEEAIAALERALEQD--PDYLPA--LPRLAELYEKLGDPEE-------ALELLRKALELDPSDDL-LLALADL 254

                          170       180
                   ....*....|....*....|
gi 1720436461  226 YSCIGKVQDAFVSYRQSIDK 245
Cdd:COG2956    255 LERKEGLEAALALLERQLRR 274
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
146-246 5.02e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 45.93  E-value: 5.02e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  146 LYETQRKYHSAKAAYEQLLQIEslPSQvkATVLQQLGWMHHNMdligdnttkERY--AIQYlQKSLEEDPNSGQSWYFLG 223
Cdd:COG3063      1 LYLKLGDLEEAEEYYEKALELD--PDN--ADALNNLGLLLLEQ---------GRYdeAIAL-EKALKLDPNNAEALLNLA 66

                           90       100
                   ....*....|....*....|...
gi 1720436461  224 RCYSCIGKVQDAFVSYRQSIDKS 246
Cdd:COG3063     67 ELLLELGDYDEALAYLERALELD 89
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 201-273 3.28e-05

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 44.21  E-value: 3.28e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720436461  201 AIQYLQKSLEEDPNS---GQSWYFLGRCYSCIGKVQDAFVSYRQSID---KSEASADTWCSIGVLYQQQNQPMDALQAY 273
Cdd:COG1729     12 AIAAFKAFLKRYPNSplaPDALYWLGEAYYALGDYDEAAEAFEKLLKrypDSPKAPDALLKLGLSYLELGDYDKARATL 90
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 65-215 5.34e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 44.41  E-value: 5.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461   65 LNKAIHFYESLIvkAEGKVESDFFCQLGHFNLLLEDYSKALSSYQRYYSLQTDywkhfqlalidcnvctlsSVEIQFHIA 144
Cdd:COG4783     20 YDEAEALLEKAL--ELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPD------------------EPEARLNLG 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720436461  145 HLYETQRKYHSAKAAYEQLLQIEslPSQvkATVLQQLGWMHHNMDligdnttKERYAIQYLQKSLEEDPNS 215
Cdd:COG4783     80 LALLKAGDYDEALALLEKALKLD--PEH--PEAYLRLARAYRALG-------RPDEAIAALEKALELDPDD 139
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 146-246 6.70e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 44.57  E-value: 6.70e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  146 LYETQRKYHSAKAAYEQLLQIEslPSQvkATVLQQLGWMHHNMdliGDNTTkeryAIQYLQKSLEEDPNSGQSWYFLGRC 225
Cdd:COG5010     63 LYNKLGDFEESLALLEQALQLD--PNN--PELYYNLALLYSRS---GDKDE----AKEYYEKALALSPDNPNAYSNLAAL 131

                           90       100
                   ....*....|....*....|.
gi 1720436461  226 YSCIGKVQDAFVSYRQSIDKS 246
Cdd:COG5010    132 LLSLGQDDEAKAALQRALGTS 152
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 90-215 1.51e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 42.69  E-value: 1.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461   90 QLGHFNLLLEDYSKALSSYQRYYSLQTDywkhfqlalidcnvctlsSVEIQFHIAHLYETQRKYHSAKAAYEQLLQIEsl 169
Cdd:COG4235     22 LLGRAYLRLGRYDEALAAYEKALRLDPD------------------NADALLDLAEALLAAGDTEEAEELLERALALD-- 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1720436461  170 PSQVKAtvLQQLGWMHHNMdligdnttkERY--AIQYLQKSLEEDPNS 215
Cdd:COG4235     82 PDNPEA--LYLLGLAAFQQ---------GDYaeAIAAWQKLLALLPAD 118
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 259-332 2.08e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 45.37  E-value: 2.08e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720436461  259 LYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGILYESCNQPQDAIKCYLNAARSKScNNTSALTSRIKFLQAQ 332
Cdd:COG3914     87 LLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNP-DFAEAYLNLGEALRRL 159
JmjC smart00558
A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of ...
 848-912 4.48e-04

A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).


Pssm-ID: 214721  Cd Length: 58  Bit Score: 39.16  E-value: 4.48e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720436461   848 QLHELTKLPafvrvvSAGNLLSHVGYTILGMNSVQLC-MKVPGSRIPGHQENNNfcSVNINIGPGD 912
Cdd:smart00558    1 QLWNLAKLP------FKLNLLSDLPEDIPGPDVGPYLyMGMAGSTTPWHIDDYD--LVNYLHQGAG 58
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 248-310 5.66e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 43.18  E-value: 5.66e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720436461  248 ASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGILYESCNQPQDAIKCYLNA 310
Cdd:COG2956      6 AAALGWYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKL 68
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 136-282 5.82e-04

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 43.36  E-value: 5.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  136 SVEIQFHIAHLYETQRKYHSAkaayEQLLQiESLPSQVKATVLQQLGwmhhnmDLIGDNTTKeryAIQYLQKSLEEDPNS 215
Cdd:COG3071    192 DPELAAAYARALIALGDHDEA----ERLLR-EALKRQWDPRLVRLYG------RLQGGDPAK---QLKRAEKWLKKHPND 257

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  216 GQSWYFLGR-CYSC--IGKVQDAFvsyRQSIdKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHG 282
Cdd:COG3071    258 PDLLLALGRlCLRNqlWGKAREYL---EAAL-ALRPSAEAYAELARLLEQLGDPEEAAEHYRKALALALG 323
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 139-307 7.22e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.92  E-value: 7.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  139 IQFHIAHLYETQRKYHSAKAAYEQLLQIEslPSQVKATVLQQlgwmhhNMDLIGDNTTKeryAIQYLQKSLEEDPNSGQS 218
Cdd:TIGR02917  467 LHNLLGAIYLGKGDLAKAREAFEKALSIE--PDFFPAAANLA------RIDIQEGNPDD---AIQRFEKVLTIDPKNLRA 535

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  219 WYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGILYESCN 298
Cdd:TIGR02917  536 ILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAG 615


                   ....*....
gi 1720436461  299 QPQDAIKCY 307
Cdd:TIGR02917  616 DLNKAVSSF 624
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 91-307 8.00e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.53  E-value: 8.00e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461   91 LGHFNLLLEDYSKALSSYQRYYSLQTDywkhfqlalidcnvctlsSVEIQFHIAHLYETQRKYHSAKAAYEQLLQIEslP 170
Cdd:TIGR02917  607 LGRAQLAAGDLNKAVSSFKKLLALQPD------------------SALALLLLADAYAVMKNYAKAITSLKRALELK--P 666

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  171 SQVKATVLQ-QLgwmhhnmdLIGDNTTKERYAI-QYLQKSLEEDPnSGQSwyFLGRCYSCIGKVQDAFVSYRQSIdKSEA 248
Cdd:TIGR02917  667 DNTEAQIGLaQL--------LLAAKRTESAKKIaKSLQKQHPKAA-LGFE--LEGDLYLRQKDYPAAIQAYRKAL-KRAP 734

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  249 SADTWCSIGVLYQQQNQPMDALQAYIcAVQLDH-GHAAAWMDLGILYESCNQPQDAIKCY 307
Cdd:TIGR02917  735 SSQNAIKLHRALLASGNTAEAVKTLE-AWLKTHpNDAVLRTALAELYLAQKDYDKAIKHY 793
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
259-332 9.39e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 39.38  E-value: 9.39e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720436461  259 LYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGILYESCNQPQDAIKcyLNAARSKSCNNTSALTSRIKFLQAQ 332
Cdd:COG3063      1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA--LEKALKLDPNNAEALLNLAELLLEL 72
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
201-301 2.75e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 40.67  E-value: 2.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  201 AIQYLQKSLEEDPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 280
Cdd:COG4785     92 AIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELD 171

                           90       100
                   ....*....|....*....|.
gi 1720436461  281 HGHAAAWMDLGILYESCNQPQ 301
Cdd:COG4785    172 PNDPERALWLYLAERKLDPEK 192
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 100-215 4.73e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 38.05  E-value: 4.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  100 DYSKALSSYQRYYSlqtDYWKHFQLAlidcnvctlssvEIQFHIAHLYETQRKYHSAKAAYEQLLQIEslPSQVKA-TVL 178
Cdd:COG1729      8 DYDEAIAAFKAFLK---RYPNSPLAP------------DALYWLGEAYYALGDYDEAAEAFEKLLKRY--PDSPKApDAL 70

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1720436461  179 QQLGWMHHNMdliGDNTTkeryAIQYLQKSLEEDPNS 215
Cdd:COG1729     71 LKLGLSYLEL---GDYDK----ARATLEELIKKYPDS 100
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 247-332 9.30e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 37.86  E-value: 9.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  247 EASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGILYESCNQPQDAIKcYLNAARSKSCNNTSALTSRI 326
Cdd:COG4783      1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIV-LLHEALELDPDEPEARLNLG 79


                   ....*.
gi 1720436461  327 KFLQAQ 332
Cdd:COG4783     80 LALLKA 85
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 150-245 9.86e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 37.28  E-value: 9.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720436461  150 QRKYHSAKAAYEQLLQieSLP-SQVKATVLQQLGWMHHNmdligdnttKERY--AIQYLQKSLEEDPNS---GQSWYFLG 223
Cdd:COG1729      6 AGDYDEAIAAFKAFLK--RYPnSPLAPDALYWLGEAYYA---------LGDYdeAAEAFEKLLKRYPDSpkaPDALLKLG 74

                           90       100
                   ....*....|....*....|..
gi 1720436461  224 RCYSCIGKVQDAFVSYRQSIDK 245
Cdd:COG1729     75 LSYLELGDYDKARATLEELIKK 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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