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Conserved domains on  [gi|1720435103|ref|XP_030107197|]
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SLIT and NTRK-like protein 2 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-197 1.70e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.76  E-value: 1.70e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103  66 QLFLNGNLLTRLyPNEFVNYSNAVTLHLGNNGLQEIrPGAFSGLKTLKRLHLNNNKLEVLREDtFLGLESLEYLQADYNY 145
Cdd:COG4886   117 SLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQ 193

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720435103 146 ISTIEAgAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTHLDLRGNRLKVMP 197
Cdd:COG4886   194 ITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP 244
LRR_8 pfam13855
Leucine rich repeat;
400-460 5.29e-14

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.16  E-value: 5.29e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720435103 400 SSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVI 460
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
379-530 6.85e-12

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 6.85e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103 379 KKLYLTGNYLQTVYKnDLLEYSSLDLLHLGNNRIAVIQEgAFTNLTSLRRLYLNGNYLEVLyPSMFDGLQSLQYLYLEYN 458
Cdd:COG4886   139 KELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGN 215

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720435103 459 VIKEIkpltfdalinlqllflnnnllrslPDNIFGGTALTRLNLRNNHFSHLPvkgVLDQLPAFIQIDLQEN 530
Cdd:COG4886   216 QLTDL------------------------PEPLANLTNLETLDLSNNQLTDLP---ELGNLTNLEELDLSNN 260
LRRCT smart00082
Leucine rich repeat C-terminal domain;
530-580 1.24e-07

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.97  E-value: 1.24e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1720435103  530 NPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAICP 580
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
216-252 1.92e-04

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.72  E-value: 1.92e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1720435103  216 NPWNCTCDLLPLKAWLDTITVFVG--EIVCETPFRLHGK 252
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRGP 39
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-197 1.70e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.76  E-value: 1.70e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103  66 QLFLNGNLLTRLyPNEFVNYSNAVTLHLGNNGLQEIrPGAFSGLKTLKRLHLNNNKLEVLREDtFLGLESLEYLQADYNY 145
Cdd:COG4886   117 SLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQ 193

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720435103 146 ISTIEAgAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTHLDLRGNRLKVMP 197
Cdd:COG4886   194 ITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP 244
LRR_8 pfam13855
Leucine rich repeat;
400-460 5.29e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.16  E-value: 5.29e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720435103 400 SSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVI 460
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
86-146 8.87e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.39  E-value: 8.87e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720435103  86 SNAVTLHLGNNGLQEIRPGAFSGLKTLKRLHLNNNKLEVLREDTFLGLESLEYLQADYNYI 146
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
379-530 6.85e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 6.85e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103 379 KKLYLTGNYLQTVYKnDLLEYSSLDLLHLGNNRIAVIQEgAFTNLTSLRRLYLNGNYLEVLyPSMFDGLQSLQYLYLEYN 458
Cdd:COG4886   139 KELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGN 215

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720435103 459 VIKEIkpltfdalinlqllflnnnllrslPDNIFGGTALTRLNLRNNHFSHLPvkgVLDQLPAFIQIDLQEN 530
Cdd:COG4886   216 QLTDL------------------------PEPLANLTNLETLDLSNNQLTDLP---ELGNLTNLEELDLSNN 260
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 358-531 2.00e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 2.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103 358 VNCQERKFTNISDLQPkPTSPKKLYLTGNYLQTVykNDLLEYSSLDLLHLGNNRIAVIqEGaFTNLTSLRRLYLNGNYLE 437
Cdd:cd21340     7 LYLNDKNITKIDNLSL-CKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKI-EN-LENLVNLKKLYLGGNRIS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103 438 VLypSMFDGLQSLQYLYLEYNVIKEIKPLTFDalinlqllflnnnllrslPDNIFG-----------G------------ 494
Cdd:cd21340    82 VV--EGLENLTNLEELHIENQRLPPGEKLTFD------------------PRSLAAlsnslrvlnisGnnidsleplapl 141

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1720435103 495 TALTRLNLRNNHFSHL-PVKGVLDQLPAFIQIDLQENP 531
Cdd:cd21340   142 RNLEQLDASNNQISDLeELLDLLSSWPSLRELDLTGNP 179
LRRCT smart00082
Leucine rich repeat C-terminal domain;
530-580 1.24e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.97  E-value: 1.24e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1720435103  530 NPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAICP 580
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 67-191 3.54e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.01  E-value: 3.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103  67 LFLNGNLLTRLyPNeFVNYSNAVTLHLGNNGLQEIRPgaFSGLKTLKRLHLNNNKLEV---------LRE---------- 127
Cdd:cd21340    29 LYLYDNKITKI-EN-LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVveglenltnLEElhienqrlpp 104

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720435103 128 --------DTFLGL-ESLEYLQADYNYISTIEagAFSKLNKLKVLILNDNLLLSLP--SNVFR-FVLLTHLDLRGN 191
Cdd:cd21340   105 gekltfdpRSLAALsNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEelLDLLSsWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 64-193 1.62e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103  64 IYQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRPGAFSGLKTLKRLHLNNNKL--EVLREdtfLG-LESLEYLQ 140
Cdd:PLN00113  142 LETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLvgQIPRE---LGqMKSLKWIY 218

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720435103 141 ADYNYIS---TIEAGAFSKLNKLKvLILNdNLLLSLPSNVFRFVLLTHLDLRGNRL 193
Cdd:PLN00113  219 LGYNNLSgeiPYEIGGLTSLNHLD-LVYN-NLTGPIPSSLGNLKNLQYLFLYQNKL 272
LRRCT smart00082
Leucine rich repeat C-terminal domain;
216-252 1.92e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.72  E-value: 1.92e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1720435103  216 NPWNCTCDLLPLKAWLDTITVFVG--EIVCETPFRLHGK 252
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRGP 39
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 381-458 2.34e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 2.34e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720435103 381 LYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYN 458
Cdd:PLN00113  145 LDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYN 222
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-197 1.70e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.76  E-value: 1.70e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103  66 QLFLNGNLLTRLyPNEFVNYSNAVTLHLGNNGLQEIrPGAFSGLKTLKRLHLNNNKLEVLREDtFLGLESLEYLQADYNY 145
Cdd:COG4886   117 SLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQ 193

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720435103 146 ISTIEAgAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTHLDLRGNRLKVMP 197
Cdd:COG4886   194 ITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP 244
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-217 3.34e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 3.34e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103  66 QLFLNGNLLTRLyPNEFVNYSNAVTLHLGNNGLQEIrPGAFSGLKTLKRLHLNNNKLEVLrEDTFLGLESLEYLQADYNY 145
Cdd:COG4886   140 ELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQ 216

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720435103 146 ISTIEAgAFSKLNKLKVLILNDNLLLSLPSnVFRFVLLTHLDLRGNRLKVMPFAGVLEHIGgimEIQLEENP 217
Cdd:COG4886   217 LTDLPE-PLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLPPLANLTNLK---TLDLSNNQ 283
LRR_8 pfam13855
Leucine rich repeat;
400-460 5.29e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.16  E-value: 5.29e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720435103 400 SSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVI 460
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
86-146 8.87e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.39  E-value: 8.87e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720435103  86 SNAVTLHLGNNGLQEIRPGAFSGLKTLKRLHLNNNKLEVLREDTFLGLESLEYLQADYNYI 146
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
111-170 2.62e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.24  E-value: 2.62e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103 111 TLKRLHLNNNKLEVLREDTFLGLESLEYLQADYNYISTIEAGAFSKLNKLKVLILNDNLL 170
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
379-530 6.85e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 6.85e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103 379 KKLYLTGNYLQTVYKnDLLEYSSLDLLHLGNNRIAVIQEgAFTNLTSLRRLYLNGNYLEVLyPSMFDGLQSLQYLYLEYN 458
Cdd:COG4886   139 KELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGN 215

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720435103 459 VIKEIkpltfdalinlqllflnnnllrslPDNIFGGTALTRLNLRNNHFSHLPvkgVLDQLPAFIQIDLQEN 530
Cdd:COG4886   216 QLTDL------------------------PEPLANLTNLETLDLSNNQLTDLP---ELGNLTNLEELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
359-531 1.38e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.18  E-value: 1.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103 359 NCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVyKNDLLEYSSLDLLHLGNNRIAVIQEgAFTNLTSLRRLYLNGNYLEV 438
Cdd:COG4886   142 DLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTD 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103 439 LyPSMFDGLQSLQYLYLEYNVIKEIkpltfdalinlqllflnnnllrslpDNIFGGTALTRLNLRNNHFSHLPvkgVLDQ 518
Cdd:COG4886   220 L-PEPLANLTNLETLDLSNNQLTDL-------------------------PELGNLTNLEELDLSNNQLTDLP---PLAN 270

                         170
                  ....*....|...
gi 1720435103 519 LPAFIQIDLQENP 531
Cdd:COG4886   271 LTNLKTLDLSNNQ 283
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 358-531 2.00e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 2.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103 358 VNCQERKFTNISDLQPkPTSPKKLYLTGNYLQTVykNDLLEYSSLDLLHLGNNRIAVIqEGaFTNLTSLRRLYLNGNYLE 437
Cdd:cd21340     7 LYLNDKNITKIDNLSL-CKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKI-EN-LENLVNLKKLYLGGNRIS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103 438 VLypSMFDGLQSLQYLYLEYNVIKEIKPLTFDalinlqllflnnnllrslPDNIFG-----------G------------ 494
Cdd:cd21340    82 VV--EGLENLTNLEELHIENQRLPPGEKLTFD------------------PRSLAAlsnslrvlnisGnnidsleplapl 141

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1720435103 495 TALTRLNLRNNHFSHL-PVKGVLDQLPAFIQIDLQENP 531
Cdd:cd21340   142 RNLEQLDASNNQISDLeELLDLLSSWPSLRELDLTGNP 179
LRR_8 pfam13855
Leucine rich repeat;
135-193 3.08e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 3.08e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103 135 SLEYLQADYNYISTIEAGAFSKLNKLKVLILNDNLLLSLPSNVFR-FVLLTHLDLRGNRL 193
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSgLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
530-580 1.24e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.97  E-value: 1.24e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1720435103  530 NPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAICP 580
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
366-528 1.68e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.55  E-value: 1.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103 366 TNISDLqPKPTSP----KKLYLTGNYLQTVyKNDLLEYSSLDLLHLGNNRIAVIqEGAFTNLTSLRRLYLNGNYLEVLyP 441
Cdd:COG4886   169 NQLTDL-PEELGNltnlKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDL-P 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103 442 SMFdGLQSLQYLYLEYNVIKEIKPLtfdalinlqllflnnnllrslpdniFGGTALTRLNLRNNHFSHLPVKGVLDQLPA 521
Cdd:COG4886   245 ELG-NLTNLEELDLSNNQLTDLPPL-------------------------ANLTNLKTLDLSNNQLTDLKLKELELLLGL 298


                  ....*..
gi 1720435103 522 FIQIDLQ 528
Cdd:COG4886   299 NSLLLLL 305
LRR_8 pfam13855
Leucine rich repeat;
424-507 4.51e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 4.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103 424 TSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDalinlqllflnnnllrslpdnifGGTALTRLNLR 503
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFS-----------------------GLPSLRYLDLS 57


                  ....
gi 1720435103 504 NNHF 507
Cdd:pfam13855  58 GNRL 61
LRR_8 pfam13855
Leucine rich repeat;
67-122 6.95e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 6.95e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720435103  67 LFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRPGAFSGLKTLKRLHLNNNKL 122
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
366-505 1.29e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.86  E-value: 1.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103 366 TNISDLQP---KPTSPKKLYLTGNYLQTVyKNDLLEYSSLDLLHLGNNRIAVIQEgaFTNLTSLRRLYLNGNYLEVLYPS 442
Cdd:COG4886   192 NQITDLPEplgNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPL 268

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720435103 443 MfdGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNN 505
Cdd:COG4886   269 A--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLL 329
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 67-191 3.54e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.01  E-value: 3.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103  67 LFLNGNLLTRLyPNeFVNYSNAVTLHLGNNGLQEIRPgaFSGLKTLKRLHLNNNKLEV---------LRE---------- 127
Cdd:cd21340    29 LYLYDNKITKI-EN-LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVveglenltnLEElhienqrlpp 104

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720435103 128 --------DTFLGL-ESLEYLQADYNYISTIEagAFSKLNKLKVLILNDNLLLSLP--SNVFR-FVLLTHLDLRGN 191
Cdd:cd21340   105 gekltfdpRSLAALsNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEelLDLLSsWPSLRELDLTGN 178
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 63-260 1.64e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.70  E-value: 1.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103  63 RIYQLFLNGNLLTRLypNEFVNYSNAVTLHLGNNGLQEIRpgAFSGLKTLKRLHLNNNKLEVLRedtflGLESLEYLQ-- 140
Cdd:cd21340     3 RITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIE-----NLENLVNLKkl 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103 141 -ADYNYISTIE----------------------------AGAFSKLNKLKVLILNDNLLLSLpSNVFRFVLLTHLDLRGN 191
Cdd:cd21340    74 yLGGNRISVVEglenltnleelhienqrlppgekltfdpRSLAALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNN 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103 192 RLKVM-PFAGVLEHIGGIMEIQLEENPwnctcdLLPLKAWLDTITVFVGEIVCetpfrLHGKDVTQLTRQ 260
Cdd:cd21340   153 QISDLeELLDLLSSWPSLRELDLTGNP------VCKKPKYRDKIILASKSLEV-----LDGKEITDTERQ 211
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 64-193 1.62e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103  64 IYQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRPGAFSGLKTLKRLHLNNNKL--EVLREdtfLG-LESLEYLQ 140
Cdd:PLN00113  142 LETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLvgQIPRE---LGqMKSLKWIY 218

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720435103 141 ADYNYIS---TIEAGAFSKLNKLKvLILNdNLLLSLPSNVFRFVLLTHLDLRGNRL 193
Cdd:PLN00113  219 LGYNNLSgeiPYEIGGLTSLNHLD-LVYN-NLTGPIPSSLGNLKNLQYLFLYQNKL 272
LRRCT smart00082
Leucine rich repeat C-terminal domain;
216-252 1.92e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.72  E-value: 1.92e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1720435103  216 NPWNCTCDLLPLKAWLDTITVFVG--EIVCETPFRLHGK 252
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRGP 39
PLN03150 PLN03150
hypothetical protein; Provisional
 91-170 5.14e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.65  E-value: 5.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103  91 LHLGNNGLQEIRPGAFSGLKTLKRLHLNNNKLEVLREDTFLGLESLEYLQADYNYISTIEAGAFSKLNKLKVLILNDNLL 170
Cdd:PLN03150  423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-197 1.23e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.23  E-value: 1.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103  40 NVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLTRLYPNEFVNYSNAVTL-HLGNNGLQEIRPGAFSGLKTLKRLHLN 118
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLlSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720435103 119 NNKLEVLREDTFLGLESLEYLQADYNyistieaGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTHLDLRGNRLKVMP 197
Cdd:COG4886    81 LLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP 152
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 96-191 1.53e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.45  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103  96 NGLQEIRPGAFSGLKTLKRLHLNNNkLEVLREDTFLG--LESLEYLqadyNYISTIEAGAFSKLNKLKVLILNDNlLLSL 173
Cdd:pfam13306  20 SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNcsLTSITIP----SSLTSIGEYAFSNCSNLKSITLPSN-LTSI 93

                          90
                  ....*....|....*...
gi 1720435103 174 PSNVFRFVLLTHLDLRGN 191
Cdd:pfam13306  94 GSYAFSNCSLKSITIPSS 111
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 381-458 2.34e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 2.34e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720435103 381 LYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYN 458
Cdd:PLN00113  145 LDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYN 222
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
338-530 4.53e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.30  E-value: 4.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103 338 ALTCPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQE 417
Cdd:COG4886    12 LLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103 418 gaFTNLTSLRRLYLNGNylevlypSMFDGLQSLQYLYLEYNVIKEIkpltfdalinlqllflnnnllrslPDNIFGGTAL 497
Cdd:COG4886    92 --LGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL------------------------PEELANLTNL 138

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1720435103 498 TRLNLRNNHFSHLPVkgVLDQLPAFIQIDLQEN 530
Cdd:COG4886   139 KELDLSNNQLTDLPE--PLGNLTNLKSLDLSNN 169
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 82-217 8.21e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 8.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103  82 FVNYSNAVTLHLGNNGLQEIRPGAFSGL---KTLKRLHLNNNKLEVLREDTFL-GL----ESLEYLQADYNYI---STIE 150
Cdd:cd00116    77 LTKGCGLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDRGLRLLAkGLkdlpPALEKLVLGRNRLegaSCEA 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720435103 151 -AGAFSKLNKLKVLILNDN---------LLLSLPSNvfrfVLLTHLDLRGNRLK---VMPFAGVLEHIGGIMEIQLEENP 217
Cdd:cd00116   157 lAKALRANRDLKELNLANNgigdagiraLAEGLKAN----CNLEVLDLNNNGLTdegASALAETLASLKSLEVLNLGDNN 232
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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