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Conserved domains on  [gi|1720394439|ref|XP_030106582|]
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F-box/WD repeat-containing protein 1A isoform X15 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 204-482 1.98e-80

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 252.26  E-value: 1.98e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 204 SKGVYCLQYDD--QKIVSGLRDNTIKIWDKSTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNAGEMLNT 279
Cdd:cd00200     9 TGGVTCVAFSPdgKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRT 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 280 LIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPtdiTLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTS 355
Cdd:cd00200    89 LTGHTSYVSSVAFspDGRILSSSSRDKTIKVWDVETG---KCLTTLRGHTDWVNSVAFspDGTFVASSSQDGTIKLWDLR 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 356 TCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKV 431
Cdd:cd00200   166 TGKCVATLTGHTGEVNSVAFSPdgEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGylLASGSEDGTIRV 245

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720394439 432 WDLMAAldprapagtLCLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWD 482
Cdd:cd00200   246 WDLRTG---------ECVQTLSGHTNSVTSLAWspDGKRLASGSADGTIRIWD 289
F-box_FBXW1A cd22182
F-box domain found in F-box/WD repeat-containing protein 1A (FBXW1A) and similar proteins; ...
 76-135 3.61e-32

F-box domain found in F-box/WD repeat-containing protein 1A (FBXW1A) and similar proteins; FBXW1A, also called E3RSIkappaB, epididymis tissue protein Li 2a, F-box and WD repeats protein beta-TrCP, or pIkappaBalpha-E3 receptor subunit, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CTNNB1, NFKBIA, NFKBIB and NFKBIE, as well as phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438953  Cd Length: 60  Bit Score: 117.47  E-value: 3.61e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439  76 MLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVR 135
Cdd:cd22182     1 MLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVR 60
Beta-TrCP_D pfam12125
D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids ...
 40-78 5.06e-25

D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids in length. It is found associated with pfam00646, pfam00400. The protein that contains this domain functions as a ubiquitin ligase. Ubiquitination is required to direct proteins towards the proteasome for degradation. This protein is part of the WD40 class of F box proteins. The D domain of these F box proteins is involved in mediating the dimerization of the protein. dimerization is necessary to polyubiquitinate substrates so this D domain is vital in directing substrates towards the proteasome for degradation.


:

Pssm-ID: 463465  Cd Length: 39  Bit Score: 97.06  E-value: 5.06e-25
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720394439  40 KYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQ 78
Cdd:pfam12125   1 KYFDKWNESDQVDFVEHLLSRMCHYQHGHINSYLKPMLQ 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 204-482 1.98e-80

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 252.26  E-value: 1.98e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 204 SKGVYCLQYDD--QKIVSGLRDNTIKIWDKSTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNAGEMLNT 279
Cdd:cd00200     9 TGGVTCVAFSPdgKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRT 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 280 LIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPtdiTLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTS 355
Cdd:cd00200    89 LTGHTSYVSSVAFspDGRILSSSSRDKTIKVWDVETG---KCLTTLRGHTDWVNSVAFspDGTFVASSSQDGTIKLWDLR 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 356 TCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKV 431
Cdd:cd00200   166 TGKCVATLTGHTGEVNSVAFSPdgEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGylLASGSEDGTIRV 245

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720394439 432 WDLMAAldprapagtLCLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWD 482
Cdd:cd00200   246 WDLRTG---------ECVQTLSGHTNSVTSLAWspDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
195-482 2.27e-78

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 250.98  E-value: 2.27e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 195 QRIHCRSETSKGVYCLQY--DDQKIVSGLRDNTIKIWDKSTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWD 270
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFspDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFspDGKLLASGSDDGTVRLWD 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 271 VNAGEMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPTditLRRVLVGHRAAVNVVDF--DDKYIVSASGD 346
Cdd:COG2319   191 LATGKLLRTLTGHTGAVRSVAFspDGKLLASGSADGTVRLWDLATGK---LLRTLTGHSGSVRSVAFspDGRLLASGSAD 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 347 RTIKVWNTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVS 422
Cdd:COG2319   268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKTLAS 347

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720394439 423 GAYDGKIKVWDLmaaldprapAGTLCLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWD 482
Cdd:COG2319   348 GSDDGTVRLWDL---------ATGELLRTLTGHTGAVTSVAFspDGRTLASGSADGTVRLWD 400
F-box_FBXW1A cd22182
F-box domain found in F-box/WD repeat-containing protein 1A (FBXW1A) and similar proteins; ...
 76-135 3.61e-32

F-box domain found in F-box/WD repeat-containing protein 1A (FBXW1A) and similar proteins; FBXW1A, also called E3RSIkappaB, epididymis tissue protein Li 2a, F-box and WD repeats protein beta-TrCP, or pIkappaBalpha-E3 receptor subunit, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CTNNB1, NFKBIA, NFKBIB and NFKBIE, as well as phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438953  Cd Length: 60  Bit Score: 117.47  E-value: 3.61e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439  76 MLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVR 135
Cdd:cd22182     1 MLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVR 60
Beta-TrCP_D pfam12125
D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids ...
 40-78 5.06e-25

D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids in length. It is found associated with pfam00646, pfam00400. The protein that contains this domain functions as a ubiquitin ligase. Ubiquitination is required to direct proteins towards the proteasome for degradation. This protein is part of the WD40 class of F box proteins. The D domain of these F box proteins is involved in mediating the dimerization of the protein. dimerization is necessary to polyubiquitinate substrates so this D domain is vital in directing substrates towards the proteasome for degradation.


Pssm-ID: 463465  Cd Length: 39  Bit Score: 97.06  E-value: 5.06e-25
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720394439  40 KYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQ 78
Cdd:pfam12125   1 KYFDKWNESDQVDFVEHLLSRMCHYQHGHINSYLKPMLQ 39
Beta-TrCP_D smart01028
D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids ...
 39-78 1.06e-22

D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids in length. It is found associated with F-box domain, WD domain. The protein that contains this domain functions as a ubiquitin ligase. Ubiquitination is required to direct proteins towards the proteasome for degradation. This protein is part of the WD40 class of F box proteins. The D domain of these F box proteins is involved in mediating the dimerisation of the protein. Dimerisation is necessary to polyubiquitinate substrates so this D domain is vital in directing substrates towards the proteasome for degradation.


Pssm-ID: 198096  Cd Length: 40  Bit Score: 90.63  E-value: 1.06e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1720394439   39 VKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQ 78
Cdd:smart01028   1 VKYFEKWSESDQVDFVEHLISRMCHYQHGHINSYLKPMLQ 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 340-494 1.80e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 66.65  E-value: 1.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 340 IVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRD---RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVrCIRFD 416
Cdd:PLN00181  548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSadpTLLASGSDDGSVKLWSINQGVSIGTIKTKANIC-CVQFP 626

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 417 N---KRIVSGAYDGKIKVWDLmaaldpRAPAGTLClrTLVEHSGRVFRLQF-DEFQIVSSSHDDTILIWDFLNDPAAHAE 492
Cdd:PLN00181  627 SesgRSLAFGSADHKVYYYDL------RNPKLPLC--TMIGHSKTVSYVRFvDSSTLVSSSTDNTLKLWDLSMSISGINE 698


                  ..
gi 1720394439 493 PP 494
Cdd:PLN00181  699 TP 700
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 82-129 8.96e-10

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 54.03  E-value: 8.96e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1720394439  82 ITALParglDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 129
Cdd:pfam12937   1 LSSLP----DEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRL 44
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 233-270 1.05e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 1.05e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1720394439  233 TLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWD 270
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
FBOX smart00256
A Receptor for Ubiquitination Targets;
91-129 4.51e-07

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 46.28  E-value: 4.51e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1720394439   91 DHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 129
Cdd:smart00256   3 DEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
WD40 pfam00400
WD domain, G-beta repeat;
397-433 5.37e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 5.37e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720394439 397 GACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWD 433
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 204-482 1.98e-80

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 252.26  E-value: 1.98e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 204 SKGVYCLQYDD--QKIVSGLRDNTIKIWDKSTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNAGEMLNT 279
Cdd:cd00200     9 TGGVTCVAFSPdgKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRT 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 280 LIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPtdiTLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTS 355
Cdd:cd00200    89 LTGHTSYVSSVAFspDGRILSSSSRDKTIKVWDVETG---KCLTTLRGHTDWVNSVAFspDGTFVASSSQDGTIKLWDLR 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 356 TCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKV 431
Cdd:cd00200   166 TGKCVATLTGHTGEVNSVAFSPdgEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGylLASGSEDGTIRV 245

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720394439 432 WDLMAAldprapagtLCLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWD 482
Cdd:cd00200   246 WDLRTG---------ECVQTLSGHTNSVTSLAWspDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
195-482 2.27e-78

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 250.98  E-value: 2.27e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 195 QRIHCRSETSKGVYCLQY--DDQKIVSGLRDNTIKIWDKSTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWD 270
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFspDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFspDGKLLASGSDDGTVRLWD 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 271 VNAGEMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPTditLRRVLVGHRAAVNVVDF--DDKYIVSASGD 346
Cdd:COG2319   191 LATGKLLRTLTGHTGAVRSVAFspDGKLLASGSADGTVRLWDLATGK---LLRTLTGHSGSVRSVAFspDGRLLASGSAD 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 347 RTIKVWNTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVS 422
Cdd:COG2319   268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKTLAS 347

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720394439 423 GAYDGKIKVWDLmaaldprapAGTLCLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWD 482
Cdd:COG2319   348 GSDDGTVRLWDL---------ATGELLRTLTGHTGAVTSVAFspDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
204-434 4.23e-68

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 224.02  E-value: 4.23e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 204 SKGVYCLQY--DDQKIVSGLRDNTIKIWDKSTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNAGEMLNT 279
Cdd:COG2319   162 SGAVTSVAFspDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKLLASGSADGTVRLWDLATGKLLRT 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 280 LIHHCEAVLHLRFN-NG-MMVTCSKDRSIAVWDMASPTditLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTS 355
Cdd:COG2319   242 LTGHSGSVRSVAFSpDGrLLASGSADGTVRLWDLATGE---LLRTLTGHSGGVNSVAFspDGKLLASGSDDGTVRLWDLA 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 356 TCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKV 431
Cdd:COG2319   319 TGKLLRTLTGHTGAVRSVAFSpdGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFspDGRTLASGSADGTVRL 398


                  ...
gi 1720394439 432 WDL 434
Cdd:COG2319   399 WDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
213-482 3.43e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 190.12  E-value: 3.43e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 213 DDQKIVSGLRDNTIKIWDKSTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNAGEMLNTLIHHCEAVLHL 290
Cdd:COG2319     5 DGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAAspDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 291 RF--NNGMMVTCSKDRSIAVWDMASPTditLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGH 366
Cdd:COG2319    85 AFspDGRLLASASADGTVRLWDLATGL---LLRTLTGHTGAVRSVAFspDGKTLASGSADGTVRLWDLATGKLLRTLTGH 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 367 KRGIACLQY-RD-RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLmaaldpra 442
Cdd:COG2319   162 SGAVTSVAFsPDgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKLLASGSADGTVRLWDL-------- 233

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1720394439 443 pAGTLCLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWD 482
Cdd:COG2319   234 -ATGKLLRTLTGHSGSVRSVAFspDGRLLASGSADGTVRLWD 274
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 236-483 2.57e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 176.37  E-value: 2.57e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 236 CKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNAGEMLntlihhceavlhlrfnngmmvtcskdrsiavwdmas 313
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFspDGKLLATGSGDGTIKVWDLETGELL------------------------------------ 44

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 314 ptditlrRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTI 389
Cdd:cd00200    45 -------RTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSpdGRILSSSSRDKTI 117

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 390 RLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLmaaldprapAGTLCLRTLVEHSGRVFRLQF--D 465
Cdd:cd00200   118 KVWDVETGKCLTTLRGHTDWVNSVAFspDGTFVASSSQDGTIKLWDL---------RTGKCVATLTGHTGEVNSVAFspD 188

                         250
                  ....*....|....*...
gi 1720394439 466 EFQIVSSSHDDTILIWDF 483
Cdd:cd00200   189 GEKLLSSSSDGTIKLWDL 206
WD40 COG2319
WD40 repeat [General function prediction only];
204-395 1.04e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 178.18  E-value: 1.04e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 204 SKGVYCLQY--DDQKIVSGLRDNTIKIWDKSTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNAGEMLNT 279
Cdd:COG2319   204 TGAVRSVAFspDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFspDGRLLASGSADGTVRLWDLATGELLRT 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 280 LIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPTditLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTS 355
Cdd:COG2319   284 LTGHSGGVNSVAFspDGKLLASGSDDGTVRLWDLATGK---LLRTLTGHTGAVRSVAFspDGKTLASGSDDGTVRLWDLA 360

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1720394439 356 TCEFVRTLNGHKRGIACLQY-RD-RLVVSGSSDNTIRLWDIE 395
Cdd:COG2319   361 TGELLRTLTGHTGAVTSVAFsPDgRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
195-356 2.58e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 144.67  E-value: 2.58e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 195 QRIHCRSETSKGVYCLQY--DDQKIVSGLRDNTIKIWDKSTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWD 270
Cdd:COG2319   237 KLLRTLTGHSGSVRSVAFspDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGKLLASGSDDGTVRLWD 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 271 VNAGEMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPTditLRRVLVGHRAAVNVVDF--DDKYIVSASGD 346
Cdd:COG2319   317 LATGKLLRTLTGHTGAVRSVAFspDGKTLASGSDDGTVRLWDLATGE---LLRTLTGHTGAVTSVAFspDGRTLASGSAD 393

                         170
                  ....*....|
gi 1720394439 347 RTIKVWNTST 356
Cdd:COG2319   394 GTVRLWDLAT 403
F-box_FBXW1A cd22182
F-box domain found in F-box/WD repeat-containing protein 1A (FBXW1A) and similar proteins; ...
 76-135 3.61e-32

F-box domain found in F-box/WD repeat-containing protein 1A (FBXW1A) and similar proteins; FBXW1A, also called E3RSIkappaB, epididymis tissue protein Li 2a, F-box and WD repeats protein beta-TrCP, or pIkappaBalpha-E3 receptor subunit, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CTNNB1, NFKBIA, NFKBIB and NFKBIE, as well as phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438953  Cd Length: 60  Bit Score: 117.47  E-value: 3.61e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439  76 MLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVR 135
Cdd:cd22182     1 MLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVR 60
F-box_FBXW1 cd22130
F-box domain found in F-box/WD repeat-containing proteins, FBXW1A, FBXW1B and similar proteins; ...
 78-128 5.65e-31

F-box domain found in F-box/WD repeat-containing proteins, FBXW1A, FBXW1B and similar proteins; FBXW1A, also called E3RSIkappaB, epididymis tissue protein Li 2a, F-box and WD repeats protein beta-TrCP, or pIkappaBalpha-E3 receptor subunit, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CTNNB1, NFKBIA, NFKBIB and NFKBIE, as well as phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. FBXW1B, also called F-box/WD repeat-containing protein 11 (FBXW11), F-box and WD repeats protein beta-TrCP2, or homologous to Slimb protein (HOS), is the substrate-recognition component of an SCF E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as IFNAR1, CEP68 and CDC25A, as well as phosphorylated CTNNB1, NFKBIA, PER1 and PER2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438902  Cd Length: 51  Bit Score: 113.72  E-value: 5.65e-31
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1720394439  78 QRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKK 128
Cdd:cd22130     1 QRDFISALPAKGLDHIAENILSYLDAKSLCAAELVCKEWYRVIADGMLWKK 51
F-box_FBXW1B cd22183
F-box domain found in F-box/WD repeat-containing protein 1B (FBXW1B) and similar proteins; ...
 78-128 1.53e-30

F-box domain found in F-box/WD repeat-containing protein 1B (FBXW1B) and similar proteins; FBXW1B, also called F-box/WD repeat-containing protein 11 (FBXW11), F-box and WD repeats protein beta-TrCP2, or homologous to Slimb protein (HOS), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as IFNAR1, CEP68 and CDC25A, as well as phosphorylated CTNNB1, NFKBIA, PER1 and PER2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438954  Cd Length: 51  Bit Score: 112.69  E-value: 1.53e-30
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1720394439  78 QRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKK 128
Cdd:cd22183     1 QRDFITALPAKGLDHIAENILSYLDAESLCAAELVCKEWQRVISEGMLWKK 51
Beta-TrCP_D pfam12125
D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids ...
 40-78 5.06e-25

D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids in length. It is found associated with pfam00646, pfam00400. The protein that contains this domain functions as a ubiquitin ligase. Ubiquitination is required to direct proteins towards the proteasome for degradation. This protein is part of the WD40 class of F box proteins. The D domain of these F box proteins is involved in mediating the dimerization of the protein. dimerization is necessary to polyubiquitinate substrates so this D domain is vital in directing substrates towards the proteasome for degradation.


Pssm-ID: 463465  Cd Length: 39  Bit Score: 97.06  E-value: 5.06e-25
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720394439  40 KYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQ 78
Cdd:pfam12125   1 KYFDKWNESDQVDFVEHLLSRMCHYQHGHINSYLKPMLQ 39
Beta-TrCP_D smart01028
D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids ...
 39-78 1.06e-22

D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids in length. It is found associated with F-box domain, WD domain. The protein that contains this domain functions as a ubiquitin ligase. Ubiquitination is required to direct proteins towards the proteasome for degradation. This protein is part of the WD40 class of F box proteins. The D domain of these F box proteins is involved in mediating the dimerisation of the protein. Dimerisation is necessary to polyubiquitinate substrates so this D domain is vital in directing substrates towards the proteasome for degradation.


Pssm-ID: 198096  Cd Length: 40  Bit Score: 90.63  E-value: 1.06e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1720394439   39 VKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQ 78
Cdd:smart01028   1 VKYFEKWSESDQVDFVEHLISRMCHYQHGHINSYLKPMLQ 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 340-494 1.80e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 66.65  E-value: 1.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 340 IVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRD---RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVrCIRFD 416
Cdd:PLN00181  548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSadpTLLASGSDDGSVKLWSINQGVSIGTIKTKANIC-CVQFP 626

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 417 N---KRIVSGAYDGKIKVWDLmaaldpRAPAGTLClrTLVEHSGRVFRLQF-DEFQIVSSSHDDTILIWDFLNDPAAHAE 492
Cdd:PLN00181  627 SesgRSLAFGSADHKVYYYDL------RNPKLPLC--TMIGHSKTVSYVRFvDSSTLVSSSTDNTLKLWDLSMSISGINE 698


                  ..
gi 1720394439 493 PP 494
Cdd:PLN00181  699 TP 700
F-box_SpPof1-like cd22147
F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar ...
 81-130 7.12e-11

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438918  Cd Length: 46  Bit Score: 57.32  E-value: 7.12e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720394439  81 FITALPARgldhIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLI 130
Cdd:cd22147     1 FLSALPVE----LSLKILSYLDAKSLCRAAQVSKKWRNLADDDELWKRMC 46
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 82-129 8.96e-10

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 54.03  E-value: 8.96e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1720394439  82 ITALParglDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 129
Cdd:pfam12937   1 LSSLP----DEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRL 44
F-box_FBXW5 cd22132
F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, ...
 96-129 7.73e-09

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438904 [Multi-domain]  Cd Length: 46  Bit Score: 51.46  E-value: 7.73e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1720394439  96 NILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 129
Cdd:cd22132    11 HIFSYLSPKDLLAAGQVCKQWYRVSRDEFLWKEL 44
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 233-270 1.05e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 1.05e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1720394439  233 TLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWD 270
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 397-433 3.09e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 3.09e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1720394439  397 GACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWD 433
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
F-box_FBXW7 cd22133
F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, ...
 68-127 3.93e-07

F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, also called Archipelago homolog (Ago), F-box and WD-40 domain-containing protein 7, F-box protein FBX30, SEL-10, or Cdc4, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438905  Cd Length: 59  Bit Score: 47.03  E-value: 3.93e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439  68 HINSYLKPMLQRDFITALPARgldhIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWK 127
Cdd:cd22133     4 HMMQVIEPQFQRDFISLLPKE----LALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 59
FBOX smart00256
A Receptor for Ubiquitination Targets;
91-129 4.51e-07

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 46.28  E-value: 4.51e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1720394439   91 DHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 129
Cdd:smart00256   3 DEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
WD40 pfam00400
WD domain, G-beta repeat;
397-433 5.37e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 5.37e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720394439 397 GACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWD 433
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
235-270 7.50e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 7.50e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1720394439 235 ECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWD 270
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
F-box_DdgacFF-like cd22148
F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) ...
 81-127 1.91e-06

F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) and similar proteins; DdgacFF, also called GTPase activating factor for raC protein FF, is a Rho GTPase-activating protein involved in the signal transduction pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438919  Cd Length: 44  Bit Score: 44.58  E-value: 1.91e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1720394439  81 FITALParglDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWK 127
Cdd:cd22148     1 FISLLP----EHLALKILSYLSPKELLIASQVSKTWRRLASSNELWK 43
F-box_FBXL4 cd22117
F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also ...
 97-129 2.08e-06

F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also called F-box and leucine-rich repeat protein 4, or F-box protein FBL4/FBL5, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It serves as a clock output molecule that regulates sleep through promotion of rhythmic degradation of the GABA(A) receptor. Biallelic pathogenic variants in FBXL4 are associated with an encephalopathic mtDNA maintenance defect syndrome that is a multi-system disease characterized by lactic acidemia, developmental delay, and hypotonia. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438889  Cd Length: 47  Bit Score: 44.54  E-value: 2.08e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1720394439  97 ILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 129
Cdd:cd22117    12 ILSYLDLPSLCRLSQTCKLFRKHCYDPLLWKEL 44
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 91-121 2.17e-06

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 44.36  E-value: 2.17e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1720394439  91 DHIAENILSYLDAKSLCAAELVCKEWYRVTS 121
Cdd:cd09917     5 DEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
F-box_FBXO48 cd22113
F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called ...
 82-129 2.48e-06

F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called FBX48, is one of the paralogs of the F-box only protein 7 (FBXO7), which is the causative gene for PARK15 (also known as Parkinsonian-pyramidal disease, PPD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438885  Cd Length: 46  Bit Score: 44.23  E-value: 2.48e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1720394439  82 ITALPARgldhIAENILSYLDAKSLCAAELVCKEWYRVTSD-GMLWKKL 129
Cdd:cd22113     1 IELLPPE----MSLRIFSQLDVQSLCRASQTCKTWNDLIENsDYLWRPH 45
F-box_FBXO41 cd22109
F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called ...
 84-129 4.03e-06

F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438881  Cd Length: 47  Bit Score: 43.86  E-value: 4.03e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1720394439  84 ALPARGLDHIaenILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 129
Cdd:cd22109     4 SLRRRDALFC---VFSYLDTKSLLRCAEVCREWRDVSRHPALWQRV 46
PTZ00421 PTZ00421
coronin; Provisional
 292-466 4.39e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.12  E-value: 4.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 292 FNNGMMVTCSKDRSIAVWDMasPTDITLRRV------LVGHRAAVNVVDFD---DKYIVSASGDRTIKVWNTSTCEFVRT 362
Cdd:PTZ00421   86 FDPQKLFTASEDGTIMGWGI--PEEGLTQNIsdpivhLQGHTKKVGIVSFHpsaMNVLASAGADMVVNVWDVERGKAVEV 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 363 LNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHE--ELVRCIRFDNKRIV-----SGAYDGKIKVWD 433
Cdd:PTZ00421  164 IKCHSDQITSLEWnlDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHAsaKSQRCLWAKRKDLIitlgcSKSQQRQIMLWD 243

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1720394439 434 lmaALDPRAPAGTlclrTLVEHSGRVFRLQFDE 466
Cdd:PTZ00421  244 ---TRKMASPYST----VDLDQSSALFIPFFDE 269
F-box_FBXO11 cd22091
F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called ...
 91-129 7.38e-06

F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called FBX11, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438863  Cd Length: 45  Bit Score: 43.18  E-value: 7.38e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720394439  91 DHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 129
Cdd:cd22091     6 DEVLLKIFSYLLEQDLCRAAQVCKRFNTLANDPELWKRL 44
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 356-393 8.01e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 8.01e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1720394439  356 TCEFVRTLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWD 393
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 318-353 9.85e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 9.85e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720394439  318 TLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWN 353
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
358-393 1.41e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.41e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1720394439 358 EFVRTLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWD 393
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
318-353 2.83e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.83e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1720394439 318 TLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWN 353
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
F-box_FBXO15 cd22093
F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called ...
 97-129 2.84e-05

F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called FBX15, has a novel dual molecular function by controlling transcriptional repression and being part of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligases, which is essential for stress response, gliotoxin production and virulence in the opportunistic human pathogen Aspergillus fumigatus. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438865  Cd Length: 46  Bit Score: 41.47  E-value: 2.84e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1720394439  97 ILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 129
Cdd:cd22093    12 ILSYLDASSLLCISCVNKLFYQLANDNALWRKL 44
F-box_ECT2L cd22173
F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and ...
 80-149 3.09e-05

F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438944  Cd Length: 52  Bit Score: 41.63  E-value: 3.09e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439  80 DFITALPArgldHIAENILSYLDAKSLCAAELVCkeWYrvtsdgmlWKKLIERmvrtDSLWRGLAERRGW 149
Cdd:cd22173     1 DFTTVLPR----FLSLYIFSFLDPRSLCRAAQVS--WH--------WKFLAEQ----DCLWMPKCVKFGW 52
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 246-398 3.61e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.62  E-value: 3.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 246 SVLCLQ-YDERVIITGSSDSTVRVWDVNAGEMLNTLIHHCEAVLHLRFNNG---MMVTCSKDRSIAVWDMASPTDITLrr 321
Cdd:PLN00181  536 SGICWNsYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSAdptLLASGSDDGSVKLWSINQGVSIGT-- 613

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 322 vlVGHRAAVNVVDFDD---KYIVSASGDRTIKVWNTSTCEF-VRTLNGHKRGIACLQYRDR-LVVSGSSDNTIRLWDIEC 396
Cdd:PLN00181  614 --IKTKANICCVQFPSesgRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSsTLVSSSTDNTLKLWDLSM 691


                  ..
gi 1720394439 397 GA 398
Cdd:PLN00181  692 SI 693
F-box_FBXW2 cd22131
F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, ...
 80-121 4.60e-05

F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, also called F-box and WD-40 domain-containing protein 2, or protein MD6, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a tumor suppressor by promoting SKP2 degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438903  Cd Length: 40  Bit Score: 40.77  E-value: 4.60e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1720394439  80 DFITALPARgldhIAENILSYLDAKSLCAAELVCKEWYRVTS 121
Cdd:cd22131     1 DFLKLLPLE----LSFYLLSFLDPESLLTCCLVSKQWNKVIS 38
PTZ00421 PTZ00421
coronin; Provisional
 212-310 6.56e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.27  E-value: 6.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 212 YDDQKIVSGLRDNTIKIWD-------KSTLECKRILTGHTGSVLCLQYD---ERVIITGSSDSTVRVWDVNAGEMLNTLI 281
Cdd:PTZ00421   86 FDPQKLFTASEDGTIMGWGipeegltQNISDPIVHLQGHTKKVGIVSFHpsaMNVLASAGADMVVNVWDVERGKAVEVIK 165

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1720394439 282 HHCEAVLHLRFN--NGMMVTCSKDRSIAVWD 310
Cdd:PTZ00421  166 CHSDQITSLEWNldGSLLCTTSKDKKLNIID 196
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 91-122 7.48e-05

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 39.75  E-value: 7.48e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1720394439  91 DHIAENILSYLDAKSLCAAELVCKEWYRVTSD 122
Cdd:cd22157     5 DDLVEEILSRLPAKSLLRFRCVCKQWNSLISS 36
F-box_unchar cd22139
F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 ...
 97-129 7.93e-05

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 (FBXO3); This subfamily corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 3 (FBXO3). FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, that mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438911  Cd Length: 45  Bit Score: 39.92  E-value: 7.93e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1720394439  97 ILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 129
Cdd:cd22139    12 IFSFLSPKDLCQVALVCRRFNRLASDESLWKQI 44
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 91-128 1.14e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 39.45  E-value: 1.14e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1720394439  91 DHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKK 128
Cdd:pfam00646   6 DDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
303-442 1.24e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.53  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 303 DRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYI-VSASGDRTIKVWNTSTCEFVRTLN--GHKRGIACLQYRDRL 379
Cdd:COG3391    45 VGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLyVANSGSGRVSVIDLATGKVVATIPvgGGPRGLAVDPDGGRL 124

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720394439 380 VVSGSSDNTIRLWDIECGACLRVLEGHEElVRCIRF--DNKRI-VSGAYDGKIKVwdLMAALDPRA 442
Cdd:COG3391   125 YVADSGNGRVSVIDTATGKVVATIPVGAG-PHGIAVdpDGKRLyVANSGSNTVSV--IVSVIDTAT 187
F-box_FBXO9 cd22089
F-box domain found in F-box only protein 9 (FBXO9) and similar proteins; FBXO9, also called ...
 81-132 1.24e-04

F-box domain found in F-box only protein 9 (FBXO9) and similar proteins; FBXO9, also called FBX9, cross-immune reaction antigen 1, renal carcinoma antigen NY-REN-57, or VCIA1, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. FBXO9 acts as an E3 ubiquitin ligase that regulates the stability and activity of peroxisome proliferator-activated receptor gamma (PPARgamma) through ubiquitination. It is also required for adipocyte differentiation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438861  Cd Length: 53  Bit Score: 39.90  E-value: 1.24e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720394439  81 FITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIER 132
Cdd:cd22089     2 HISALPSEILLYILRWVVSDLDLRSLEQLSLVCRKFYLLARDPSIWRLACER 53
F-box_FBXO16-like cd22094
F-box domain found in F-box only protein 16 (FBXO16), epithelial cell-transforming sequence 2 ...
 80-127 1.46e-04

F-box domain found in F-box only protein 16 (FBXO16), epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; This family includes FBXO16 and ECT2L. FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438866  Cd Length: 49  Bit Score: 39.35  E-value: 1.46e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1720394439  80 DFITALPARgldhIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWK 127
Cdd:cd22094     1 DFTRVLPRF----LSLYIFSYLDPRSLCRAAQVSWYWKFLCESDELWL 44
F-box_FBXO45 cd22111
F-box domain found in F-box only protein 45 (FBXO45) and similar proteins; FBXO45, also called ...
 83-121 1.91e-04

F-box domain found in F-box only protein 45 (FBXO45) and similar proteins; FBXO45, also called FBX45, or F-box/SPRY domain-containing protein 1, functions as the substrate-recognition component of E3 ubiquitin ligase complexes. It is critical for synaptogenesis, neuronal migration, and synaptic transmission. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438883  Cd Length: 36  Bit Score: 38.80  E-value: 1.91e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720394439  83 TALPARGLdhiaENILSYLDAKSLCAAELVCKEWYRVTS 121
Cdd:cd22111     2 ARLPSRVL----EVIFSYLDLPDLRNCSLVCKSWYRLLN 36
F-box_FBXO7 cd22087
F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called ...
 96-129 2.56e-04

F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called FBX7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes BIRC2 and DLGAP5. FBXO7 plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. It promotes MFN1 ubiquitination. FBXO7 acts as a cell cycle regulator by enhancing cyclin D/cyclin-dependent kinase 6 (Cdk6) complex formation and stabilizing levels of p27, a cyclin-dependent kinase inhibitor. Mutations in the FBXO7 (PARK15) gene have been implicated in a juvenile form of parkinsonism called parkinsonian pyramidal syndrome (PPS), characterized by Parkinsonian symptoms and pyramidal tract signs. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438859  Cd Length: 45  Bit Score: 38.82  E-value: 2.56e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1720394439  96 NILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 129
Cdd:cd22087    11 RILSLLDVRSLLSLSQVCRDLNSATNDQLLWRFL 44
F-box_FBXO16 cd22172
F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called ...
 97-149 2.59e-04

F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438943  Cd Length: 55  Bit Score: 38.80  E-value: 2.59e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720394439  97 ILSYLDAKSLCAAELVCkeWYrvtsdgmlWKKLIErmvrTDSLWRGLAERRGW 149
Cdd:cd22172    17 IFSFLDPRSLCRCAQVC--WY--------WKYLTE----LDQLWMPKCLRFGW 55
F-box_FBXL5 cd22118
F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also ...
 96-126 3.30e-04

F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also called F-box and leucine-rich repeat protein 5, F-box protein FBL4/FBL5, or p45SKP2-like protein, is the substrate-recognition component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438890  Cd Length: 41  Bit Score: 38.09  E-value: 3.30e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1720394439  96 NILSYLDAKSLCAAELVCKEWYRVTSDGMLW 126
Cdd:cd22118    11 KIFSYLNPQDLCRCAQVCTKWSQLARDGSLW 41
F-box_FBXW12 cd22137
F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; ...
 97-129 3.34e-04

F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; FBXW12, also called F-box and WD-40 domain-containing protein 12, or F-box only protein 35 (FBXO35), is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It functions as an epithelial growth suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438909  Cd Length: 44  Bit Score: 38.13  E-value: 3.34e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1720394439  97 ILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 129
Cdd:cd22137    11 IFSFLDAFSLLQAAQVNKQWNKVADSDYLWRNL 43
F-box_AtGID2-like cd22151
F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, ...
 91-126 3.54e-04

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438922  Cd Length: 44  Bit Score: 38.07  E-value: 3.54e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1720394439  91 DHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLW 126
Cdd:cd22151     5 DDLLQEIFKRLDPKSLARAACVCRRWRAAARSESLW 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 448-482 5.17e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 5.17e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1720394439  448 CLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWD 482
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
F-box_EMI cd22086
F-box domain found in the early mitotic inhibitor (EMI) family of F-box proteins; The EMI ...
 88-116 9.13e-04

F-box domain found in the early mitotic inhibitor (EMI) family of F-box proteins; The EMI family includes FBX5 (EMI1) and FBX43 (EMI2), which are anaphase-promoting complex/cyclosome (APC/C) inhibitors that bind APC/C-CCD20 (Cell division cycle protein 20) and/or APC/C-CDH1 (CDC20 homologue 1) complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438858  Cd Length: 48  Bit Score: 37.09  E-value: 9.13e-04
                          10        20
                  ....*....|....*....|....*....
gi 1720394439  88 RGLDHIAENILSYLDAKSLCAAELVCKEW 116
Cdd:cd22086     6 RNCPHILSKILSYLSPEDLCRVSCVSKTW 34
F-box_FBXO42 cd22110
F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called ...
 91-122 1.23e-03

F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called FBX42, or just one F-box and Kelch domain-containing protein (JFK), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It specifically recognizes p53/TP53, promoting its ubiquitination and degradation. FBXO42 is also involved in the ubiquitin-proteasome system that may play a role in the pathogenesis of Parkinson's disease (PD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438882  Cd Length: 38  Bit Score: 36.55  E-value: 1.23e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1720394439  91 DHIAENILSYLD-AKSLCAAELVCKEWYRVTSD 122
Cdd:cd22110     6 EEILEYILSYLSpYGDLKSAALVCKRWHRIIKG 38
PTZ00420 PTZ00420
coronin; Provisional
 269-353 1.40e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.09  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394439 269 WDVNAGEMLNT--------------LIHHCEAVLHLRFN---NGMMVTCSKDRSIAVWDMASpTDITLRRV------LVG 325
Cdd:PTZ00420   45 WEVEGGGLIGAirlenqmrkppvikLKGHTSSILDLQFNpcfSEILASGSEDLTIRVWEIPH-NDESVKEIkdpqciLKG 123

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1720394439 326 HRAAVNVVDFD--DKYIVSASG-DRTIKVWN 353
Cdd:PTZ00420  124 HKKKISIIDWNpmNYYIMCSSGfDSFVNIWD 154
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 274-310 1.47e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.47e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1720394439  274 GEMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWD 310
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
448-482 2.61e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 2.61e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1720394439 448 CLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWD 482
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
F-box_FBXL7 cd22120
F-box domain found in F-box/LRR-repeat protein 7 (FBXL7) and similar proteins; FBXL7, also ...
 91-129 2.68e-03

F-box domain found in F-box/LRR-repeat protein 7 (FBXL7) and similar proteins; FBXL7, also called F-box and leucine-rich repeat protein 7, or F-box protein FBL6/FBL7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of Aurora kinase A (AURKA) during mitosis, causing mitotic arrest. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438892  Cd Length: 44  Bit Score: 35.82  E-value: 2.68e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720394439  91 DHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 129
Cdd:cd22120     6 DDVILQIFSHLPTNQLCRCARVCRRWYNLAWDPRLWTTI 44
F-box_FBXL12 cd22123
F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also ...
 97-127 3.29e-03

F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438895  Cd Length: 42  Bit Score: 35.40  E-value: 3.29e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1720394439  97 ILSYLDAKSLCAAELVCKEWYRVTSDGMLWK 127
Cdd:cd22123    12 ILSYLPVRDLLRISRVCKRWRRLVYDKTLWR 42
F-box_FBXO18 cd22095
F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called ...
 82-129 5.31e-03

F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called FBX18, or F-box DNA helicase 1 (FBH1), is a 3'-5' DNA helicase and the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438867  Cd Length: 48  Bit Score: 34.94  E-value: 5.31e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1720394439  82 ITALParglDHIAENILSYLDAKSLC-AAELVCKEWYRVTSDGM--LWKKL 129
Cdd:cd22095     2 IQQLP----EELLRNIFAFLPAEDLYqNISLVCRHWRDIVSDPLfiPWKKL 48
F-box_FBXO8 cd22088
F-box domain found in F-box only protein 8 (FBXO8) and similar proteins; FBXO8, also called ...
 93-129 6.56e-03

F-box domain found in F-box only protein 8 (FBXO8) and similar proteins; FBXO8, also called FBX8, or F-box/SEC7 protein FBS, is a novel component of F-box proteins which contains an F-box domain and a putative Sec7 domain. FBX8 was originally identified as a Skp1-binding protein. It is involved in the ubiquitin-dependent proteolytic pathway. It acts as a metastasis suppressor that functions through mTOR signaling pathway. FBXO8 may promote the activation of ADP-ribosylation factor (ARF) through replacement of GDP with GTP. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438860  Cd Length: 46  Bit Score: 34.61  E-value: 6.56e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1720394439  93 IAENILSYLDAKSLCAAELVckeWYRVTSDGMLWKKL 129
Cdd:cd22088    11 LSLTVLSHLNATDLCLASCV---WQDLANDELLWQGL 44
F-box_FBXL2-like cd22115
F-box domain found in F-box/LRR-repeat protein 2 (FBXL2), F-box/LRR-repeat protein 20 (FBXL20) ...
 97-127 7.33e-03

F-box domain found in F-box/LRR-repeat protein 2 (FBXL2), F-box/LRR-repeat protein 20 (FBXL20) and similar proteins; The family includes FBXL2 and FBXL30. FBXL2, also called F-box and leucine-rich repeat protein 2, or F-box protein FBL2/FBL3, is a calcium-activated substrate-recognition component of an SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. FBXL20, also called SCRAPPER, F-box and leucine-rich repeat protein 20, or F-box/LRR-repeat protein 2-like, is a component of a synapse-localized SCF-type E3 ubiquitin ligase which regulates neural transmission. It is widely expressed in the central nervous system and plays an important role in the ubiquitin-dependent degradation of regulating synaptic membrane exocytosis 1 (RIM1), which is an important factor in the release of synaptic vesicles. It may also mediate the ubiquitin degradation of E-cadherin resulting in an increased invasive ability of malignant cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438887  Cd Length: 45  Bit Score: 34.70  E-value: 7.33e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1720394439  97 ILSYLDAKSLCAAELVCKEWYRVTSDGMLWK 127
Cdd:cd22115    15 IFSFLDVVTLCRCAQVSKYWNVLALDGSNWQ 45
WD40 pfam00400
WD domain, G-beta repeat;
274-310 7.95e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.24  E-value: 7.95e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720394439 274 GEMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWD 310
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
F-box_FBXO3 cd22084
F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called ...
 96-129 8.31e-03

F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438856  Cd Length: 49  Bit Score: 34.54  E-value: 8.31e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1720394439  96 NILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 129
Cdd:cd22084    11 NILSFLDYRDLISCSQVCRRLNQLCSHDPLWKRL 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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