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Conserved domains on  [gi|1720390694|ref|XP_030105781|]
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target of rapamycin complex subunit LST8 isoform X2 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-321 1.06e-58

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 193.97  E-value: 1.06e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694  10 SDPVILATAGYDHTVRFWQAHSGICTRTVQ-HQDSVNALEITPDRSMIAAAGYQH-IRMYDLNSnnPNPIISYDGVSKNI 87
Cdd:COG2319    88 PDGRLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFSPDGKTLASGSADGtVRLWDLAT--GKLLRTLTGHSGAV 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694  88 ASVGFHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIP 166
Cdd:COG2319   166 TSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTGhTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694 167 EPESSITSAHIDPDASYMAAVNSAGNCYVWNLTGGigddvtQLIpkTKIPAHTRYALQCRFSPDSTcvLLATCSADQTCK 246
Cdd:COG2319   244 GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG------ELL--RTLTGHSGGVNSVAFSPDGK--LLASGSDDGTVR 313

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720390694 247 IWRTSNFSLMTELSikssnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 321
Cdd:COG2319   314 LWDLATGKLLRTLT--------GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-321 1.06e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 193.97  E-value: 1.06e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694  10 SDPVILATAGYDHTVRFWQAHSGICTRTVQ-HQDSVNALEITPDRSMIAAAGYQH-IRMYDLNSnnPNPIISYDGVSKNI 87
Cdd:COG2319    88 PDGRLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFSPDGKTLASGSADGtVRLWDLAT--GKLLRTLTGHSGAV 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694  88 ASVGFHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIP 166
Cdd:COG2319   166 TSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTGhTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694 167 EPESSITSAHIDPDASYMAAVNSAGNCYVWNLTGGigddvtQLIpkTKIPAHTRYALQCRFSPDSTcvLLATCSADQTCK 246
Cdd:COG2319   244 GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG------ELL--RTLTGHSGGVNSVAFSPDGK--LLASGSDDGTVR 313

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720390694 247 IWRTSNFSLMTELSikssnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 321
Cdd:COG2319   314 LWDLATGKLLRTLT--------GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-298 6.10e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 152.10  E-value: 6.10e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694  14 ILATAGYDHTVRFWQAHSGICTRTVQ-HQDSVNALEITPDRSMIAAAGYQH-IRMYDLNSNNPnpIISYDGVSKNIASVG 91
Cdd:cd00200    23 LLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASADGTYLASGSSDKtIRLWDLETGEC--VRTLTGHTSYVSSVA 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694  92 FHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQ-VNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPES 170
Cdd:cd00200   101 FSPDGRILSSSSRDKTIKVWDVETG--KCLTTLRgHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694 171 SITSAHIDPDASYMAAVNSAGNCYVWNLTGGigdDVTQLIPktkipAHTRYALQCRFSPDStcVLLATCSADQTCKIWRT 250
Cdd:cd00200   179 EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG---KCLGTLR-----GHENGVNSVAFSPDG--YLLASGSEDGTIRVWDL 248

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1720390694 251 SNFSLMTELSikssnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLW 298
Cdd:cd00200   249 RTGECVQTLS--------GHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 10-113 4.95e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.16  E-value: 4.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694  10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSVNALEITPD--RSMIAAAGYQHIRMYDLnsNNPN-PIISYDGVSKN 86
Cdd:PLN00181  586 ADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSEsgRSLAFGSADHKVYYYDL--RNPKlPLCTMIGHSKT 663

                          90       100
                  ....*....|....*....|....*..
gi 1720390694  87 IASVGFhEDGRWMYTGGEDCTARIWDL 113
Cdd:PLN00181  664 VSYVRF-VDSSTLVSSSTDNTLKLWDL 689
WD40 pfam00400
WD domain, G-beta repeat;
75-112 7.04e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 7.04e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1720390694  75 NPIISYDGVSKNIASVGFHEDGRWMYTGGEDCTARIWD 112
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 73-112 1.42e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.42e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1720390694   73 NPNPIISYDGVSKNIASVGFHEDGRWMYTGGEDCTARIWD 112
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-321 1.06e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 193.97  E-value: 1.06e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694  10 SDPVILATAGYDHTVRFWQAHSGICTRTVQ-HQDSVNALEITPDRSMIAAAGYQH-IRMYDLNSnnPNPIISYDGVSKNI 87
Cdd:COG2319    88 PDGRLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFSPDGKTLASGSADGtVRLWDLAT--GKLLRTLTGHSGAV 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694  88 ASVGFHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIP 166
Cdd:COG2319   166 TSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTGhTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694 167 EPESSITSAHIDPDASYMAAVNSAGNCYVWNLTGGigddvtQLIpkTKIPAHTRYALQCRFSPDSTcvLLATCSADQTCK 246
Cdd:COG2319   244 GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG------ELL--RTLTGHSGGVNSVAFSPDGK--LLASGSDDGTVR 313

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720390694 247 IWRTSNFSLMTELSikssnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 321
Cdd:COG2319   314 LWDLATGKLLRTLT--------GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380
WD40 COG2319
WD40 repeat [General function prediction only];
14-298 7.21e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.56  E-value: 7.21e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694  14 ILATAGYDHTVRFWQAHSGICTRTVQ-HQDSVNALEITPDRSMIAAAGYQH-IRMYDLNSNNPnpIISYDGVSKNIASVG 91
Cdd:COG2319   134 TLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSPDGKLLASGSDDGtVRLWDLATGKL--LRTLTGHTGAVRSVA 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694  92 FHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPES 170
Cdd:COG2319   212 FSPDGKLLASGSADGTVRLWDLATG--KLLRTLTGhSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG 289

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694 171 SITSAHIDPDASYMAAVNSAGNCYVWNLTGGigddvtQLIpkTKIPAHTRYALQCRFSPDSTcvLLATCSADQTCKIWRT 250
Cdd:COG2319   290 GVNSVAFSPDGKLLASGSDDGTVRLWDLATG------KLL--RTLTGHTGAVRSVAFSPDGK--TLASGSDDGTVRLWDL 359

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1720390694 251 SNFSLMTELsikssnpgESSRGWMWGCAFSGDSQYIVTASSDNLARLW 298
Cdd:COG2319   360 ATGELLRTL--------TGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-298 6.10e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 152.10  E-value: 6.10e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694  14 ILATAGYDHTVRFWQAHSGICTRTVQ-HQDSVNALEITPDRSMIAAAGYQH-IRMYDLNSNNPnpIISYDGVSKNIASVG 91
Cdd:cd00200    23 LLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASADGTYLASGSSDKtIRLWDLETGEC--VRTLTGHTSYVSSVA 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694  92 FHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQ-VNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPES 170
Cdd:cd00200   101 FSPDGRILSSSSRDKTIKVWDVETG--KCLTTLRgHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694 171 SITSAHIDPDASYMAAVNSAGNCYVWNLTGGigdDVTQLIPktkipAHTRYALQCRFSPDStcVLLATCSADQTCKIWRT 250
Cdd:cd00200   179 EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG---KCLGTLR-----GHENGVNSVAFSPDG--YLLASGSEDGTIRVWDL 248

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1720390694 251 SNFSLMTELSikssnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLW 298
Cdd:cd00200   249 RTGECVQTLS--------GHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
14-252 9.61e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.59  E-value: 9.61e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694  14 ILATAGYDHTVRFWQAHSGICTRTVQ-HQDSVNALEITPDRSMIAAAGYQH-IRMYDLNSnnPNPIISYDGVSKNIASVG 91
Cdd:COG2319   176 LLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGtVRLWDLAT--GKLLRTLTGHSGSVRSVA 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694  92 FHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPES 170
Cdd:COG2319   254 FSPDGRLLASGSADGTVRLWDLATG--ELLRTLTGhSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694 171 SITSAHIDPDASYMAAVNSAGNCYVWNLTGGIgddvtqliPKTKIPAHTRYALQCRFSPDSTcvLLATCSADQTCKIWRT 250
Cdd:COG2319   332 AVRSVAFSPDGKTLASGSDDGTVRLWDLATGE--------LLRTLTGHTGAVTSVAFSPDGR--TLASGSADGTVRLWDL 401


                  ..
gi 1720390694 251 SN 252
Cdd:COG2319   402 AT 403
WD40 COG2319
WD40 repeat [General function prediction only];
8-321 1.64e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 143.51  E-value: 1.64e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694   8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSVNALEITPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVSKNI 87
Cdd:COG2319     2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694  88 ASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQcQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPE 167
Cdd:COG2319    82 LSVAFSPDGRLLASASADGTVRLWDLATGLLL-RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694 168 PESSITSAHIDPDASYMAAVNSAGNCYVWNLTGGigddvtQLIpkTKIPAHTRYALQCRFSPDSTcvLLATCSADQTCKI 247
Cdd:COG2319   161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG------KLL--RTLTGHTGAVRSVAFSPDGK--LLASGSADGTVRL 230

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720390694 248 WRTSNFSLMTELsikssnpgESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 321
Cdd:COG2319   231 WDLATGKLLRTL--------TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF 296
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-249 2.42e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.16  E-value: 2.42e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694  15 LATAGYDHTVRFWQAHSGICTRT-VQHQDSVNALEITPDRSMIAAAGYQH-IRMYDLNSNNPnpIISYDGVSKNIASVGF 92
Cdd:cd00200    66 LASGSSDKTIRLWDLETGECVRTlTGHTSYVSSVAFSPDGRILSSSSRDKtIKVWDVETGKC--LTTLRGHTDWVNSVAF 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694  93 HEDGRWMYTGGEDCTARIWDLRSrnLQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPESS 171
Cdd:cd00200   144 SPDGTFVASSSQDGTIKLWDLRT--GKCVATLTGhTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG 221

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720390694 172 ITSAHIDPDASYMAAVNSAGNCYVWNLTGGigddvtqlIPKTKIPAHTRYALQCRFSPDSTCvlLATCSADQTCKIWR 249
Cdd:cd00200   222 VNSVAFSPDGYLLASGSEDGTIRVWDLRTG--------ECVQTLSGHTNSVTSLAWSPDGKR--LASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
91-322 2.98e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.83  E-value: 2.98e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694  91 GFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVcLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPES 170
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLA-ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694 171 SITSAHIDPDASYMAAVNSAGNCYVWNLTGGIgddvtqliPKTKIPAHTRYALQCRFSPDSTcvLLATCSADQTCKIWRT 250
Cdd:COG2319    80 AVLSVAFSPDGRLLASASADGTVRLWDLATGL--------LLRTLTGHTGAVRSVAFSPDGK--TLASGSADGTVRLWDL 149

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720390694 251 SNFSLMTELSikssnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 322
Cdd:COG2319   150 ATGKLLRTLT--------GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS 213
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-155 7.19e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 96.25  E-value: 7.19e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694   8 VGSDPVILATAGYDHTVRFWQAHSGICTRT-VQHQDSVNALEITPD-RSMIAAAGYQHIRMYDLNSnnPNPIISYDGVSK 85
Cdd:cd00200   143 FSPDGTFVASSSQDGTIKLWDLRTGKCVATlTGHTGEVNSVAFSPDgEKLLSSSSDGTIKLWDLST--GKCLGTLRGHEN 220

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694  86 NIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLqCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWD 155
Cdd:cd00200   221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEC-VQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 169-324 6.65e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.78  E-value: 6.65e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694 169 ESSITSAHIDPDASYMAAVNSAGNCYVWNLTGGIgddvtqliPKTKIPAHTRYALQCRFSPDSTcvLLATCSADQTCKIW 248
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--------LLRTLKGHTGPVRDVAASADGT--YLASGSSDKTIRLW 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720390694 249 RTSNFSLMTELsikssnpgESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 324
Cdd:cd00200    79 DLETGECVRTL--------TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD 146
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 215-324 4.60e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.46  E-value: 4.60e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694 215 IPAHTRYALQCRFSPDSTcvLLATCSADQTCKIWRTSNFSLMTELSIKSsnpgessrGWMWGCAFSGDSQYIVTASSDNL 294
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGK--LLATGSGDGTIKVWDLETGELLRTLKGHT--------GPVRDVAASADGTYLASGSSDKT 74

                          90       100       110
                  ....*....|....*....|....*....|
gi 1720390694 295 ARLWCVETGEIKREYGGHQKAVVCLAFNDS 324
Cdd:cd00200    75 IRLWDLETGECVRTLTGHTSYVSSVAFSPD 104
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 10-113 4.95e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.16  E-value: 4.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390694  10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSVNALEITPD--RSMIAAAGYQHIRMYDLnsNNPN-PIISYDGVSKN 86
Cdd:PLN00181  586 ADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSEsgRSLAFGSADHKVYYYDL--RNPKlPLCTMIGHSKT 663

                          90       100
                  ....*....|....*....|....*..
gi 1720390694  87 IASVGFhEDGRWMYTGGEDCTARIWDL 113
Cdd:PLN00181  664 VSYVRF-VDSSTLVSSSTDNTLKLWDL 689
WD40 pfam00400
WD domain, G-beta repeat;
75-112 7.04e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 7.04e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1720390694  75 NPIISYDGVSKNIASVGFHEDGRWMYTGGEDCTARIWD 112
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 73-112 1.42e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.42e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1720390694   73 NPNPIISYDGVSKNIASVGFHEDGRWMYTGGEDCTARIWD 112
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 211-248 6.22e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 6.22e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720390694  211 PKTKIPAHTRYALQCRFSPDSTcvLLATCSADQTCKIW 248
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGK--YLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
211-248 3.08e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 3.08e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1720390694 211 PKTKIPAHTRYALQCRFSPDSTcvLLATCSADQTCKIW 248
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGK--LLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 271-298 6.68e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 6.68e-03
                           10        20
                   ....*....|....*....|....*...
gi 1720390694  271 RGWMWGCAFSGDSQYIVTASSDNLARLW 298
Cdd:smart00320  12 TGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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