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Conserved domains on  [gi|1720388715|ref|XP_030105278|]
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ankyrin repeat domain-containing protein 12 isoform X3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
150-268 7.72e-38

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 144.71  E-value: 7.72e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  150 RQKDKINKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDD 229
Cdd:COG0666    108 EAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGE 187

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1720388715  230 TPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVA 268
Cdd:COG0666    188 TPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLA 226
PTZ00121 super family cl31754
MAEBL; Provisional
 359-1142 4.42e-08

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 59.00  E-value: 4.42e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  359 KEQRRENESEAERSGLFAKQEKTFYSKSFKTKKQKPSRVLCSSTESSDE--EGLQNRKISTACSVAESSHPDMQAKKE-- 434
Cdd:PTZ00121  1084 KEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEarKAEDARKAEEARKAEDAKRVEIARKAEda 1163

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  435 --YEYKQKGKVKRKLKNQNKNKENQELKQEKEGKENSRIATLTVNTALDCSEKYREEGNFRKSFSPKDDTSLHLFHISTG 512
Cdd:PTZ00121  1164 rkAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAK 1243

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  513 KSPK-HSCGLSEKQTPLKQEHTKACISPGSSEMSLQPDLTRYDNAEPESSNVKSYKHKEKNKQQKDFHIEFGEKSNAKIK 591
Cdd:PTZ00121  1244 KAEEeRNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKK 1323

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  592 DEDHNPAFENSDCTLKKMDKEGKTLKKHKLKHKEKDKEKHKKEVEGEKEKYKNKDNAKELQRSIEFDRefwkenffKSDE 671
Cdd:PTZ00121  1324 AEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKK--------KADE 1395

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  672 TEDLFLTMEHESIIEKKTKMEKNMKDDRSAKEKHVSKERNFKEEREKTKKENEKSLREEKVKDPKEEKDSVSTEKEAECC 751
Cdd:PTZ00121  1396 AKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEA 1475

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  752 SVGVSVSQEAAGLH--SSEKEMDAEKQERHTKEREKSDRRFQTKEKELDRNERKFSEKEKKIKHEHKSEREKLDFSDCTD 829
Cdd:PTZ00121  1476 KKKAEEAKKADEAKkkAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAE 1555

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  830 RVREKDKLysHQTERCHKDSEKLKNTVRKTDDRER-------------NREKADRKHDREKPERERYLAENKEKHLEKRK 896
Cdd:PTZ00121  1556 ELKKAEEK--KKAEEAKKAEEDKNMALRKAEEAKKaeearieevmklyEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKK 1633

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  897 QSDSSEYSKSEKVRTKDRDREGEKKEKLRDKESVNvtnlKHLQEERKSSTGDSSGKTQHEKALSLKERARD----EPLKT 972
Cdd:PTZ00121  1634 KVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAK----KAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEakkaEELKK 1709

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  973 PDGKEKDKKDIDRyKERDKRKDKAQlntliRLKSETEKLKPKLSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQ 1052
Cdd:PTZ00121  1710 KEAEEKKKAEELK-KAEEENKIKAE-----EAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEE 1783

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715 1053 WHRKHKEKIKQKEKERLRNrTCLELKVKDKEKTKHAPTESKSKELTRSRSSELTDVY------SKEKQSKDVGSNRSQSV 1126
Cdd:PTZ00121  1784 ELDEEDEKRRMEVDKKIKD-IFDNFANIIEGGKEGNLVINDSKEMEDSAIKEVADSKnmqleeADAFEKHKFNKNNENGE 1862

                          810
                   ....*....|....*.
gi 1720388715 1127 DNRNVLNLGKPSYISE 1142
Cdd:PTZ00121  1863 DGNKEADFNKEKDLKE 1878
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
150-268 7.72e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 144.71  E-value: 7.72e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  150 RQKDKINKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDD 229
Cdd:COG0666    108 EAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGE 187

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1720388715  230 TPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVA 268
Cdd:COG0666    188 TPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLA 226
Ank_2 pfam12796
Ankyrin repeats (3 copies);
166-254 1.41e-21

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 90.95  E-value: 1.41e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  166 LHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIaAGADVNTQGlDDDTPLHDSASSGHRDIVK 245
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKD-NGRTALHYAARSGHLEIVK 78


                   ....*....
gi 1720388715  246 LLLRHGGNP 254
Cdd:pfam12796   79 LLLEKGADI 87
PHA03095 PHA03095
ankyrin-like protein; Provisional
 155-267 1.38e-15

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 81.99  E-value: 1.38e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  155 INKRNERGETPLHM---AAIRGDVKQVKELISLGANVNVKDFAGWTPLH-EACNVGYYDVAKILIAAGADVNTQGLDDDT 230
Cdd:PHA03095    40 VNFRGEYGKTPLHLylhYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHlYLYNATTLDVIKLLIKAGADVNAKDKVGRT 119

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1720388715  231 PLHDSASSG--HRDIVKLLLRHGGNPFQANKHGERPVDV 267
Cdd:PHA03095   120 PLHVYLSGFniNPKVIRLLLRKGADVNALDLYGMTPLAV 158
PTZ00121 PTZ00121
MAEBL; Provisional
 359-1142 4.42e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 59.00  E-value: 4.42e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  359 KEQRRENESEAERSGLFAKQEKTFYSKSFKTKKQKPSRVLCSSTESSDE--EGLQNRKISTACSVAESSHPDMQAKKE-- 434
Cdd:PTZ00121  1084 KEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEarKAEDARKAEEARKAEDAKRVEIARKAEda 1163

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  435 --YEYKQKGKVKRKLKNQNKNKENQELKQEKEGKENSRIATLTVNTALDCSEKYREEGNFRKSFSPKDDTSLHLFHISTG 512
Cdd:PTZ00121  1164 rkAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAK 1243

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  513 KSPK-HSCGLSEKQTPLKQEHTKACISPGSSEMSLQPDLTRYDNAEPESSNVKSYKHKEKNKQQKDFHIEFGEKSNAKIK 591
Cdd:PTZ00121  1244 KAEEeRNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKK 1323

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  592 DEDHNPAFENSDCTLKKMDKEGKTLKKHKLKHKEKDKEKHKKEVEGEKEKYKNKDNAKELQRSIEFDRefwkenffKSDE 671
Cdd:PTZ00121  1324 AEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKK--------KADE 1395

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  672 TEDLFLTMEHESIIEKKTKMEKNMKDDRSAKEKHVSKERNFKEEREKTKKENEKSLREEKVKDPKEEKDSVSTEKEAECC 751
Cdd:PTZ00121  1396 AKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEA 1475

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  752 SVGVSVSQEAAGLH--SSEKEMDAEKQERHTKEREKSDRRFQTKEKELDRNERKFSEKEKKIKHEHKSEREKLDFSDCTD 829
Cdd:PTZ00121  1476 KKKAEEAKKADEAKkkAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAE 1555

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  830 RVREKDKLysHQTERCHKDSEKLKNTVRKTDDRER-------------NREKADRKHDREKPERERYLAENKEKHLEKRK 896
Cdd:PTZ00121  1556 ELKKAEEK--KKAEEAKKAEEDKNMALRKAEEAKKaeearieevmklyEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKK 1633

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  897 QSDSSEYSKSEKVRTKDRDREGEKKEKLRDKESVNvtnlKHLQEERKSSTGDSSGKTQHEKALSLKERARD----EPLKT 972
Cdd:PTZ00121  1634 KVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAK----KAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEakkaEELKK 1709

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  973 PDGKEKDKKDIDRyKERDKRKDKAQlntliRLKSETEKLKPKLSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQ 1052
Cdd:PTZ00121  1710 KEAEEKKKAEELK-KAEEENKIKAE-----EAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEE 1783

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715 1053 WHRKHKEKIKQKEKERLRNrTCLELKVKDKEKTKHAPTESKSKELTRSRSSELTDVY------SKEKQSKDVGSNRSQSV 1126
Cdd:PTZ00121  1784 ELDEEDEKRRMEVDKKIKD-IFDNFANIIEGGKEGNLVINDSKEMEDSAIKEVADSKnmqleeADAFEKHKFNKNNENGE 1862

                          810
                   ....*....|....*.
gi 1720388715 1127 DNRNVLNLGKPSYISE 1142
Cdd:PTZ00121  1863 DGNKEADFNKEKDLKE 1878
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 644-1154 1.03e-05

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 50.74  E-value: 1.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  644 NKDNAKELQRSIEFDREFWKENFFKSDETEDLFLTMEHESIIEKKTKMEKNMKDDRSAKEKHVSKERNFKEEREKTKKEN 723
Cdd:pfam02463  215 LKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKE 294

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  724 EKSLREEKVkdpKEEKDSVSTEKEaeccsvgVSVSQEAAGLHSSEKEMDAEKQERHTKEREKSDRRFQTKEKELDRNERK 803
Cdd:pfam02463  295 EEELKSELL---KLERRKVDDEEK-------LKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKL 364

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  804 FSEKEKKIKHEHKSEREKLDFSDCTDRVREKDKLYSHQTERCHKDSEKLKNTVRKTDDRERNREKADRK---HDREKPER 880
Cdd:pfam02463  365 QEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEeeeESIELKQG 444

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  881 ERYLAENKEKHLEKRKQSDSSEYSKSEKVRTKDRDREGEKKEKLRDKESVNVTNLKHLQEERKSSTGDSSGKTQHEKALS 960
Cdd:pfam02463  445 KLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRI 524

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  961 LKERARDEPLKTPDGKEKDKKDIDRYKERDKRKDKAqlntLIRLKSETEKLKPKLSPASKDTRPKEKRLVNDDLMQTSFE 1040
Cdd:pfam02463  525 ISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEV----EERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEID 600

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715 1041 RMLSLKDLEieqwhrKHKEKIKQKEKERLRNRTCLELKVKDKEKTKHAPTESKS---KELTRSRSSELTDVYSKEKQSKD 1117
Cdd:pfam02463  601 PILNLAQLD------KATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLrkgVSLEEGLAEKSEVKASLSELTKE 674

                          490       500       510
                   ....*....|....*....|....*....|....*..
gi 1720388715 1118 VGSNRSQSVDNRNVLNLGKPSYISESGSNRSPRSEGE 1154
Cdd:pfam02463  675 LLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEE 711
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 162-233 1.12e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 50.40  E-value: 1.12e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  162 GETPLHMAAIRGDVKQVKELISLGANVNV--------------KDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLD 227
Cdd:cd22192     89 GETALHIAVVNQNLNLVRELIARGADVVSpratgtffrpgpknLIYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSL 168


                   ....*.
gi 1720388715  228 DDTPLH 233
Cdd:cd22192    169 GNTVLH 174
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 195-222 2.82e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 42.57  E-value: 2.82e-05
                            10        20
                    ....*....|....*....|....*...
gi 1720388715   195 GWTPLHEACNVGYYDVAKILIAAGADVN 222
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADIN 29
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 818-942 1.27e-03

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 43.75  E-value: 1.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  818 EREKL-DFSDCTDRVREKDKLySHQTERCHKDSEKLKNTvRKTDDRERNREKADRKHDREKPERERYLAENKEK-HLEKR 895
Cdd:TIGR01622    6 ERERLrDSSSAGDRDRRRDKG-RERSRDRSRDRERSRSR-RRDRHRDRDYYRGRERRSRSRRPNRRYRPREKRRrRGDSY 83

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1720388715  896 KQSDSSEYSKSEKVRTKDRDREGEKKEKlRDKESVNVTNLKHLQEER 942
Cdd:TIGR01622   84 RRRRDDRRSRREKPRARDGTPEPLTEDE-RDRRTVFVQQLAARARER 129
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
150-268 7.72e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 144.71  E-value: 7.72e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  150 RQKDKINKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDD 229
Cdd:COG0666    108 EAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGE 187

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1720388715  230 TPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVA 268
Cdd:COG0666    188 TPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLA 226
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
151-268 1.36e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 135.47  E-value: 1.36e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  151 QKDKINKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDT 230
Cdd:COG0666     76 AGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNT 155

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1720388715  231 PLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVA 268
Cdd:COG0666    156 PLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLA 193
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
155-288 9.84e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 126.99  E-value: 9.84e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  155 INKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHD 234
Cdd:COG0666    146 VNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1720388715  235 SASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSGDDE 288
Cdd:COG0666    226 AAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLA 279
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
152-268 5.78e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 98.49  E-value: 5.78e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  152 KDKINKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTP 231
Cdd:COG0666     44 LLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETP 123

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1720388715  232 LHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVA 268
Cdd:COG0666    124 LHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160
Ank_2 pfam12796
Ankyrin repeats (3 copies);
166-254 1.41e-21

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 90.95  E-value: 1.41e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  166 LHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIaAGADVNTQGlDDDTPLHDSASSGHRDIVK 245
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKD-NGRTALHYAARSGHLEIVK 78


                   ....*....
gi 1720388715  246 LLLRHGGNP 254
Cdd:pfam12796   79 LLLEKGADI 87
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
155-263 1.49e-20

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 94.25  E-value: 1.49e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  155 INKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHD 234
Cdd:COG0666    179 VNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLL 258

                           90       100
                   ....*....|....*....|....*....
gi 1720388715  235 SASSGHRDIVKLLLRHGGNPFQANKHGER 263
Cdd:COG0666    259 AAAAGAALIVKLLLLALLLLAAALLDLLT 287
PHA03095 PHA03095
ankyrin-like protein; Provisional
 155-267 1.38e-15

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 81.99  E-value: 1.38e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  155 INKRNERGETPLHM---AAIRGDVKQVKELISLGANVNVKDFAGWTPLH-EACNVGYYDVAKILIAAGADVNTQGLDDDT 230
Cdd:PHA03095    40 VNFRGEYGKTPLHLylhYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHlYLYNATTLDVIKLLIKAGADVNAKDKVGRT 119

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1720388715  231 PLHDSASSG--HRDIVKLLLRHGGNPFQANKHGERPVDV 267
Cdd:PHA03095   120 PLHVYLSGFniNPKVIRLLLRKGADVNALDLYGMTPLAV 158
Ank_2 pfam12796
Ankyrin repeats (3 copies);
155-224 2.72e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.84  E-value: 2.72e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  155 INKRNERGETPLHMAAIRGDVKQVKELISlGANVNVKDFaGWTPLHEACNVGYYDVAKILIAAGADVNTQ 224
Cdd:pfam12796   23 ANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVKLLLEKGADINVK 90
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 154-268 4.57e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 80.01  E-value: 4.57e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  154 KINKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLH 233
Cdd:PHA02874   116 DVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLH 195

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1720388715  234 DSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVA 268
Cdd:PHA02874   196 NAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNA 230
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 97-253 5.43e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 79.71  E-value: 5.43e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715   97 STPVSILFGYPLSERKQM---ALLMQMTARDNSPDSTPSHPSQATPAQKKTPSS-----SSRQKDkINKRNERGETPLHM 168
Cdd:PHA03100    69 STPLHYLSNIKYNLTDVKeivKLLLEYGANVNAPDNNGITPLLYAISKKSNSYSiveylLDNGAN-VNIKNSDGENLLHL 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  169 AAIRGDVK------------------QVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDT 230
Cdd:PHA03100   148 YLESNKIDlkilkllidkgvdinaknRVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDT 227

                          170       180
                   ....*....|....*....|...
gi 1720388715  231 PLHDSASSGHRDIVKLLLRHGGN 253
Cdd:PHA03100   228 PLHIAILNNNKEIFKLLLNNGPS 250
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 93-261 9.02e-13

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 73.78  E-value: 9.02e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715   93 GTKKSTPVSILFgyplserKQMALLMQMTARDNSPDSTpshpSQATPAQKKTPSSSSRQKDKINkrnergETPLHMAAIR 172
Cdd:PTZ00322    23 GSRKRRAKPISF-------ERMAAIQEEIARIDTHLEA----LEATENKDATPDHNLTTEEVID------PVVAHMLTVE 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  173 -------GDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVK 245
Cdd:PTZ00322    86 lcqlaasGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165

                          170
                   ....*....|....*.
gi 1720388715  246 LLLRHGGNPFQANKHG 261
Cdd:PTZ00322   166 LLSRHSQCHFELGANA 181
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 129-253 9.52e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 73.56  E-value: 9.52e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  129 STPSHPSQATPAQKK-TPSSSSRQKDkINKRNERGETPLHMAAIRG-DVKQVKELISLGANVNVKDFAGWTPLHEACNVG 206
Cdd:PHA02876   274 NTPLHHASQAPSLSRlVPKLLERGAD-VNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHQASTLD 352

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1720388715  207 YY-DVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGN 253
Cdd:PHA02876   353 RNkDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGAD 400
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
152-268 7.29e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 65.36  E-value: 7.29e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  152 KDKINKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTP 231
Cdd:COG0666     11 LLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTL 90

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1720388715  232 LHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVA 268
Cdd:COG0666     91 LHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLA 127
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 155-268 8.61e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 66.53  E-value: 8.61e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  155 INKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEAcnVGYYDVAKILIAAGADVNTQGLDDDTPLHD 234
Cdd:PHA02874   183 ANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNA--IIHNRSAIELLINNASINDQDIDGSTPLHH 260

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1720388715  235 SAS-SGHRDIVKLLLRHGGNPFQANKHGERPVDVA 268
Cdd:PHA02874   261 AINpPCDIDIIDILLYHKADISIKDNKGENPIDTA 295
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 155-251 1.92e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 65.67  E-value: 1.92e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  155 INKRNE-RGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLH 233
Cdd:PHA02878   160 INMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLH 239

                           90
                   ....*....|....*....
gi 1720388715  234 DSASS-GHRDIVKLLLRHG 251
Cdd:PHA02878   240 ISVGYcKDYDILKLLLEHG 258
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 123-268 3.01e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 64.90  E-value: 3.01e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  123 RDNSPDSTPSHPSQATPAQKKTPSSSSRQKdKINKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEA 202
Cdd:PHA02878   163 KDRHKGNTALHYATENKDQRLTELLLSYGA-NVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHIS 241

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  203 cnVGY---YDVAKILIAAGADVNTQG-LDDDTPLHDSASSghRDIVKLLLRHGGNPFQANKHGERPVDVA 268
Cdd:PHA02878   242 --VGYckdYDILKLLLEHGVDVNAKSyILGLTALHSSIKS--ERKLKLLLEYGADINSLNSYKLTPLSSA 307
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 163-250 3.14e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 64.63  E-value: 3.14e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  163 ETPLHMAAIRGDVKQVKELISLGANVN---VKDfaGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSG 239
Cdd:PHA02875    69 ESELHDAVEEGDVKAVEELLDLGKFADdvfYKD--GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMG 146

                           90
                   ....*....|.
gi 1720388715  240 HRDIVKLLLRH 250
Cdd:PHA02875   147 DIKGIELLIDH 157
PHA03095 PHA03095
ankyrin-like protein; Provisional
 155-264 1.25e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 63.12  E-value: 1.25e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  155 INKRNERGETPLH--MAAIRGDVKQVKELISLGANVNVKDFAGWTPLH-----EACNVgyyDVAKILIAAGADVNTQGLD 227
Cdd:PHA03095   110 VNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAvllksRNANV---ELLRLLIDAGADVYAVDDR 186

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1720388715  228 DDTPLHDSASSGHRD--IVKLLLRHGGNPFQANKHGERP 264
Cdd:PHA03095   187 FRSLLHHHLQSFKPRarIVRELIRAGCDPAATDMLGNTP 225
PHA03095 PHA03095
ankyrin-like protein; Provisional
 174-253 1.59e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 62.73  E-value: 1.59e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  174 DVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKI---LIAAGADVNTQGLDDDTPLHDSASSGHR-DIVKLLLR 249
Cdd:PHA03095    26 TVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIvrlLLEAGADVNAPERCGFTPLHLYLYNATTlDVIKLLIK 105


                   ....
gi 1720388715  250 HGGN 253
Cdd:PHA03095   106 AGAD 109
Ank_4 pfam13637
Ankyrin repeats (many copies);
164-215 1.63e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 55.36  E-value: 1.63e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1720388715  164 TPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILI 215
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 154-223 2.11e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 61.99  E-value: 2.11e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  154 KINKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNT 223
Cdd:PHA03100   184 PINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKT 253
Ank_4 pfam13637
Ankyrin repeats (many copies);
195-248 2.12e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.97  E-value: 2.12e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1720388715  195 GWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLL 248
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 174-268 9.64e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 60.28  E-value: 9.64e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  174 DVKQVKELISLGANVNVKD-FAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGG 252
Cdd:PHA02878   146 EAEITKLLLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGA 225

                           90
                   ....*....|....*.
gi 1720388715  253 NPFQANKHGERPVDVA 268
Cdd:PHA02878   226 STDARDKCGNTPLHIS 241
PTZ00121 PTZ00121
MAEBL; Provisional
 359-1142 4.42e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 59.00  E-value: 4.42e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  359 KEQRRENESEAERSGLFAKQEKTFYSKSFKTKKQKPSRVLCSSTESSDE--EGLQNRKISTACSVAESSHPDMQAKKE-- 434
Cdd:PTZ00121  1084 KEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEarKAEDARKAEEARKAEDAKRVEIARKAEda 1163

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  435 --YEYKQKGKVKRKLKNQNKNKENQELKQEKEGKENSRIATLTVNTALDCSEKYREEGNFRKSFSPKDDTSLHLFHISTG 512
Cdd:PTZ00121  1164 rkAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAK 1243

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  513 KSPK-HSCGLSEKQTPLKQEHTKACISPGSSEMSLQPDLTRYDNAEPESSNVKSYKHKEKNKQQKDFHIEFGEKSNAKIK 591
Cdd:PTZ00121  1244 KAEEeRNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKK 1323

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  592 DEDHNPAFENSDCTLKKMDKEGKTLKKHKLKHKEKDKEKHKKEVEGEKEKYKNKDNAKELQRSIEFDRefwkenffKSDE 671
Cdd:PTZ00121  1324 AEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKK--------KADE 1395

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  672 TEDLFLTMEHESIIEKKTKMEKNMKDDRSAKEKHVSKERNFKEEREKTKKENEKSLREEKVKDPKEEKDSVSTEKEAECC 751
Cdd:PTZ00121  1396 AKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEA 1475

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  752 SVGVSVSQEAAGLH--SSEKEMDAEKQERHTKEREKSDRRFQTKEKELDRNERKFSEKEKKIKHEHKSEREKLDFSDCTD 829
Cdd:PTZ00121  1476 KKKAEEAKKADEAKkkAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAE 1555

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  830 RVREKDKLysHQTERCHKDSEKLKNTVRKTDDRER-------------NREKADRKHDREKPERERYLAENKEKHLEKRK 896
Cdd:PTZ00121  1556 ELKKAEEK--KKAEEAKKAEEDKNMALRKAEEAKKaeearieevmklyEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKK 1633

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  897 QSDSSEYSKSEKVRTKDRDREGEKKEKLRDKESVNvtnlKHLQEERKSSTGDSSGKTQHEKALSLKERARD----EPLKT 972
Cdd:PTZ00121  1634 KVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAK----KAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEakkaEELKK 1709

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  973 PDGKEKDKKDIDRyKERDKRKDKAQlntliRLKSETEKLKPKLSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQ 1052
Cdd:PTZ00121  1710 KEAEEKKKAEELK-KAEEENKIKAE-----EAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEE 1783

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715 1053 WHRKHKEKIKQKEKERLRNrTCLELKVKDKEKTKHAPTESKSKELTRSRSSELTDVY------SKEKQSKDVGSNRSQSV 1126
Cdd:PTZ00121  1784 ELDEEDEKRRMEVDKKIKD-IFDNFANIIEGGKEGNLVINDSKEMEDSAIKEVADSKnmqleeADAFEKHKFNKNNENGE 1862

                          810
                   ....*....|....*.
gi 1720388715 1127 DNRNVLNLGKPSYISE 1142
Cdd:PTZ00121  1863 DGNKEADFNKEKDLKE 1878
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 164-253 1.74e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 55.77  E-value: 1.74e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  164 TPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHR-D 242
Cdd:PHA02875   137 SPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNKiD 216

                           90
                   ....*....|.
gi 1720388715  243 IVKLLLRHGGN 253
Cdd:PHA02875   217 IVRLFIKRGAD 227
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
154-232 3.06e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 54.19  E-value: 3.06e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720388715  154 KINKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPL 232
Cdd:COG0666    211 DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
Ank_5 pfam13857
Ankyrin repeats (many copies);
155-202 3.53e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 48.88  E-value: 3.53e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1720388715  155 INKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEA 202
Cdd:pfam13857    9 LNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 166-229 5.04e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 54.87  E-value: 5.04e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720388715  166 LHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDD 229
Cdd:PLN03192   626 LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTDDD 689
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 95-252 6.49e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 54.68  E-value: 6.49e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715   95 KKSTPVSILF--GYplsERKQMALLMQMTARDNSPDS---TPSHPSQATPAQKKTPSSSSRQKDKINKRNERGETPLHMA 169
Cdd:PHA02876   306 KGETPLYLMAknGY---DTENIRTLIMLGADVNAADRlyiTPLHQASTLDRNKDIVITLLELGANVNARDYCDKTPIHYA 382

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  170 AIRGDV----------------------------------KQVKELISLGANVNVKDFAGWTPLHEAC-NVGYYDVAKIL 214
Cdd:PHA02876   383 AVRNNVviintlldygadiealsqkigtalhfalcgtnpyMSVKTLIDRGANVNSKNKDLSTPLHYACkKNCKLDVIEML 462

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1720388715  215 IAAGADVNTQGLDDDTPLhdSASSGHRDIVKLLLRHGG 252
Cdd:PHA02876   463 LDNGADVNAINIQNQYPL--LIALEYHGIVNILLHYGA 498
PTZ00121 PTZ00121
MAEBL; Provisional
 345-983 1.04e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 54.38  E-value: 1.04e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  345 EEISKMIDDRHI---LRKEQRRENESEAERSGLFAKQEKTFYSKSFKTKKQKPSRVLCSSTESSDEEGL---QNRKISTA 418
Cdd:PTZ00121  1215 EEARKAEDAKKAeavKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELkkaEEKKKADE 1294

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  419 CSVAESSHPDMQAKKEYEYKQKGKVKRKLKNQNKNKENQELKQEKEGKENSRIATLTVNTALDCSEKYREEGNfrksfsp 498
Cdd:PTZ00121  1295 AKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAE------- 1367

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  499 kddtslhlfhistgkspkhscgLSEKQTplKQEHTKACISPGSSEMSLQPDLTRyDNAEPESSNVKSYKHKEKNKQQKDf 578
Cdd:PTZ00121  1368 ----------------------AAEKKK--EEAKKKADAAKKKAEEKKKADEAK-KKAEEDKKKADELKKAAAAKKKAD- 1421

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  579 hiEFGEKSNAKIKDEDHNPAFENSdctlKKMDKEGKTLKKHKLKHKEKDKEKHKKEVEGEKEKYKNKDNAKELQRSIEFD 658
Cdd:PTZ00121  1422 --EAKKKAEEKKKADEAKKKAEEA----KKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEA 1495

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  659 REFWKENFFKSDETE--DLFLTMEHESIIEKKTKMEKNMKDDRSAKEKHVSKERNFKEEREKTKKENEKSLREEKvkdPK 736
Cdd:PTZ00121  1496 KKKADEAKKAAEAKKkaDEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAK---KA 1572

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  737 EEKDSVSTEKEAECCSVGVSVSQEAAGLHSSEKEMDAEKQERHTKEREKSDrrfQTKEKEldrNERKFSEKEKKIKHEHK 816
Cdd:PTZ00121  1573 EEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAE---ELKKAE---EEKKKVEQLKKKEAEEK 1646

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  817 SEREKLdfsdctDRVREKDKLYSHQTERCHKDSEKLKNTVRKTDDRERNREKADRKHDREKPERE---RYLAENKEKHLE 893
Cdd:PTZ00121  1647 KKAEEL------KKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEelkKKEAEEKKKAEE 1720

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  894 KRKQSDSSEYSKSEKVRTKDRDREGEKKEKLRDKESVNVTNLKHLQEERksstgdsSGKTQHEKALSLKERARDEPLKTP 973
Cdd:PTZ00121  1721 LKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKK-------AEEIRKEKEAVIEEELDEEDEKRR 1793

                          650
                   ....*....|
gi 1720388715  974 DGKEKDKKDI 983
Cdd:PTZ00121  1794 MEVDKKIKDI 1803
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 161-262 1.13e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 53.72  E-value: 1.13e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  161 RGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKIL--IAAGADVNT--------------- 223
Cdd:PLN03192   557 KGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILyhFASISDPHAagdllctaakrndlt 636

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1720388715  224 -------QGLDDDTPLHDSASS-------GHRDIVKLLLRHGGNPFQANKHGE 262
Cdd:PLN03192   637 amkellkQGLNVDSEDHQGATAlqvamaeDHVDMVRLLIMNGADVDKANTDDD 689
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 155-261 1.34e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 51.36  E-value: 1.34e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  155 INKRNERGETPLHMAAIRGDVKQ--VKELISLGANVNVKdfagwTPLHEACNVGYY---------DVAKILIAAGADVNT 223
Cdd:PHA02859    44 VNDCNDLYETPIFSCLEKDKVNVeiLKFLIENGADVNFK-----TRDNNLSALHHYlsfnknvepEILKILIDSGSSITE 118

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1720388715  224 QGLDDDTPLHDSAS--SGHRDIVKLLLRHGGNPFQANKHG 261
Cdd:PHA02859   119 EDEDGKNLLHMYMCnfNVRINVIKLLIDSGVSFLNKDFDN 158
Ank_5 pfam13857
Ankyrin repeats (many copies);
214-268 2.34e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.57  E-value: 2.34e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720388715  214 LIAAG-ADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVA 268
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 164-253 3.01e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 51.97  E-value: 3.01e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  164 TPLHMA--AIRGDVkqVKELISLGANVNVKDFAGWTPLHEACNVGYY-----DVAKILIAAGADVNTQGLDDDTPLHDSA 236
Cdd:PHA03100    37 LPLYLAkeARNIDV--VKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNGITPLLYAI 114

                           90
                   ....*....|....*....
gi 1720388715  237 S--SGHRDIVKLLLRHGGN 253
Cdd:PHA03100   115 SkkSNSYSIVEYLLDNGAN 133
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 160-268 4.16e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 51.53  E-value: 4.16e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  160 ERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSG 239
Cdd:PHA02875   100 KDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKG 179

                           90       100
                   ....*....|....*....|....*....
gi 1720388715  240 HRDIVKLLLRHGGNPfqaNKHGERPvDVA 268
Cdd:PHA02875   180 DIAICKMLLDSGANI---DYFGKNG-CVA 204
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 161-192 5.34e-06

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 44.97  E-value: 5.34e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1720388715  161 RGETPLHMAAIR-GDVKQVKELISLGANVNVKD 192
Cdd:pfam00023    1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 644-1154 1.03e-05

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 50.74  E-value: 1.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  644 NKDNAKELQRSIEFDREFWKENFFKSDETEDLFLTMEHESIIEKKTKMEKNMKDDRSAKEKHVSKERNFKEEREKTKKEN 723
Cdd:pfam02463  215 LKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKE 294

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  724 EKSLREEKVkdpKEEKDSVSTEKEaeccsvgVSVSQEAAGLHSSEKEMDAEKQERHTKEREKSDRRFQTKEKELDRNERK 803
Cdd:pfam02463  295 EEELKSELL---KLERRKVDDEEK-------LKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKL 364

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  804 FSEKEKKIKHEHKSEREKLDFSDCTDRVREKDKLYSHQTERCHKDSEKLKNTVRKTDDRERNREKADRK---HDREKPER 880
Cdd:pfam02463  365 QEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEeeeESIELKQG 444

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  881 ERYLAENKEKHLEKRKQSDSSEYSKSEKVRTKDRDREGEKKEKLRDKESVNVTNLKHLQEERKSSTGDSSGKTQHEKALS 960
Cdd:pfam02463  445 KLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRI 524

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  961 LKERARDEPLKTPDGKEKDKKDIDRYKERDKRKDKAqlntLIRLKSETEKLKPKLSPASKDTRPKEKRLVNDDLMQTSFE 1040
Cdd:pfam02463  525 ISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEV----EERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEID 600

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715 1041 RMLSLKDLEieqwhrKHKEKIKQKEKERLRNRTCLELKVKDKEKTKHAPTESKS---KELTRSRSSELTDVYSKEKQSKD 1117
Cdd:pfam02463  601 PILNLAQLD------KATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLrkgVSLEEGLAEKSEVKASLSELTKE 674

                          490       500       510
                   ....*....|....*....|....*....|....*..
gi 1720388715 1118 VGSNRSQSVDNRNVLNLGKPSYISESGSNRSPRSEGE 1154
Cdd:pfam02463  675 LLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEE 711
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 162-233 1.12e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 50.40  E-value: 1.12e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  162 GETPLHMAAIRGDVKQVKELISLGANVNV--------------KDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLD 227
Cdd:cd22192     89 GETALHIAVVNQNLNLVRELIARGADVVSpratgtffrpgpknLIYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSL 168


                   ....*.
gi 1720388715  228 DDTPLH 233
Cdd:cd22192    169 GNTVLH 174
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 178-265 1.14e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 49.96  E-value: 1.14e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  178 VKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQA 257
Cdd:PHA02874   107 IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVK 186


                   ....*...
gi 1720388715  258 NKHGERPV 265
Cdd:PHA02874   187 DNNGESPL 194
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 142-253 1.25e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 50.45  E-value: 1.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  142 KKTPSSSSRQKDKINKRNErgetplHMAAIRGDVKQ-----VKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIA 216
Cdd:PHA02876   126 KEAISGNDIHYDKINESIE------YMKLIKERIQQdelliAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLS 199

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1720388715  217 AGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGN 253
Cdd:PHA02876   200 YGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSN 236
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 195-222 1.38e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 43.43  E-value: 1.38e-05
                           10        20
                   ....*....|....*....|....*....
gi 1720388715  195 GWTPLHEAC-NVGYYDVAKILIAAGADVN 222
Cdd:pfam00023    2 GNTPLHLAAgRRGNLEIVKLLLSKGADVN 30
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 211-268 1.41e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 50.28  E-value: 1.41e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720388715  211 AKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVA 268
Cdd:PTZ00322    98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELA 155
PHA03095 PHA03095
ankyrin-like protein; Provisional
 158-249 1.47e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.02  E-value: 1.47e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  158 RNERGETPLHMAAIRGDVK--QVKELISLGANVNVKDFAGWTPLHEAcnvGYYD---VAKILIAAGADVNTQGLDDDTPL 232
Cdd:PHA03095   218 TDMLGNTPLHSMATGSSCKrsLVLPLLIAGISINARNRYGQTPLHYA---AVFNnprACRRLIALGADINAVSSDGNTPL 294

                           90
                   ....*....|....*..
gi 1720388715  233 HDSASSGHRDIVKLLLR 249
Cdd:PHA03095   295 SLMVRNNNGRAVRAALA 311
PHA03095 PHA03095
ankyrin-like protein; Provisional
 155-202 2.52e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 49.25  E-value: 2.52e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1720388715  155 INKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEA 202
Cdd:PHA03095   250 INARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLM 297
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 195-222 2.82e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 42.57  E-value: 2.82e-05
                            10        20
                    ....*....|....*....|....*...
gi 1720388715   195 GWTPLHEACNVGYYDVAKILIAAGADVN 222
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADIN 29
Ank_5 pfam13857
Ankyrin repeats (many copies);
186-233 4.04e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.10  E-value: 4.04e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1720388715  186 ANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLH 233
Cdd:pfam13857    7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 227-254 4.26e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 42.19  E-value: 4.26e-05
                            10        20
                    ....*....|....*....|....*...
gi 1720388715   227 DDDTPLHDSASSGHRDIVKLLLRHGGNP 254
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 161-190 4.43e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 42.19  E-value: 4.43e-05
                            10        20        30
                    ....*....|....*....|....*....|
gi 1720388715   161 RGETPLHMAAIRGDVKQVKELISLGANVNV 190
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02798 PHA02798
ankyrin-like protein; Provisional
 175-261 9.13e-05

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 47.52  E-value: 9.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  175 VKQVKELISLGANVNVKDFAGWTPLheaC----NVGYY----DVAKILIAAGADVNTQGLDDDTPLHDSASSGH---RDI 243
Cdd:PHA02798    51 TDIVKLFINLGANVNGLDNEYSTPL---CtilsNIKDYkhmlDIVKILIENGADINKKNSDGETPLYCLLSNGYinnLEI 127

                           90
                   ....*....|....*...
gi 1720388715  244 VKLLLRHGGNPFQANKHG 261
Cdd:PHA02798   128 LLFMIENGADTTLLDKDG 145
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 726-1024 1.33e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 47.04  E-value: 1.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  726 SLREEKVKDPKEEKDSVSTEKEAECCSVgvsvsQEAAGLHSSEKEMDAE---------KQERHTKEREKSDRRFQTKEKE 796
Cdd:pfam17380  285 SERQQQEKFEKMEQERLRQEKEEKAREV-----ERRRKLEEAEKARQAEmdrqaaiyaEQERMAMERERELERIRQEERK 359

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  797 LDRNERKFSEKEKKIKHEHKSEREKLDFSDCTDRVRE------KDKLYSHQTERCHKDSEKLKNTVRKTDDRERNR---- 866
Cdd:pfam17380  360 RELERIRQEEIAMEISRMRELERLQMERQQKNERVRQeleaarKVKILEEERQRKIQQQKVEMEQIRAEQEEARQRevrr 439

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  867 --EKADRKHDR---EKPERERYLAENKEKHLEKRKQSDSSEYSKSEKVRTKDRDR---------------EGEKKEKLRD 926
Cdd:pfam17380  440 leEERAREMERvrlEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRkilekeleerkqamiEEERKRKLLE 519

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  927 KESVNVTNLKHLQEERKSSTGDSSGKTQHEKALSLKERAR--DEPLKTPDGKEKDKKDIDRYKERDKRKDKAQLNTLIrl 1004
Cdd:pfam17380  520 KEMEERQKAIYEEERRREAEEERRKQQEMEERRRIQEQMRkaTEERSRLEAMEREREMMRQIVESEKARAEYEATTPI-- 597

                          330       340
                   ....*....|....*....|
gi 1720388715 1005 ksetEKLKPKLSPASKDTRP 1024
Cdd:pfam17380  598 ----TTIKPIYRPRISEYQP 613
PHA03095 PHA03095
ankyrin-like protein; Provisional
 158-254 1.54e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 46.56  E-value: 1.54e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  158 RNERGETPLHMAA--IRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKI--LIAAGADVNTQGLDDDTPLH 233
Cdd:PHA03095   183 VDDRFRSLLHHHLqsFKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQTPLH 262

                           90       100
                   ....*....|....*....|.
gi 1720388715  234 DSASSGHRDIVKLLLRHGGNP 254
Cdd:PHA03095   263 YAAVFNNPRACRRLIALGADI 283
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 227-259 1.98e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.35  E-value: 1.98e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1720388715  227 DDDTPLHDSA-SSGHRDIVKLLLRHGGNPFQANK 259
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 169-247 2.64e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 46.01  E-value: 2.64e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720388715  169 AAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLL 247
Cdd:PLN03192   532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRIL 610
Ank_2 pfam12796
Ankyrin repeats (3 copies);
153-192 2.86e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 41.64  E-value: 2.86e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1720388715  153 DKINKRN-ERGETPLHMAAIRGDVKQVKELISLGANVNVKD 192
Cdd:pfam12796   51 EHADVNLkDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 161-190 4.00e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 39.55  E-value: 4.00e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1720388715  161 RGETPLHMAAIRGDVKQVKELISLGANVNV 190
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 195-223 4.28e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 39.16  E-value: 4.28e-04
                           10        20
                   ....*....|....*....|....*....
gi 1720388715  195 GWTPLHEACNVGYYDVAKILIAAGADVNT 223
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 759-1041 8.11e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 44.34  E-value: 8.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  759 QEAAGLHSSEKEMDAEKQERHTKEREKSDRRFQTKEKELDRNERKFSEKEKKIKHEHKSEREKLDFSDCTDRVREKDKly 838
Cdd:pfam17380  281 QKAVSERQQQEKFEKMEQERLRQEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAMERERELERIRQEER-- 358

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  839 SHQTERCHKDS-----------EKLKNTVRKTDDRERNREKADRKHDREKPERERYLAENKEKHLEKRKQsdsSEYSKSE 907
Cdd:pfam17380  359 KRELERIRQEEiameisrmrelERLQMERQQKNERVRQELEAARKVKILEEERQRKIQQQKVEMEQIRAE---QEEARQR 435

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  908 KVRTKDRDREGEkKEKLRDKE---SVNVTNLKHLQEERKSStgdssgKTQHEKALSLKERARDEPLKTPDGKEKDKKDID 984
Cdd:pfam17380  436 EVRRLEEERARE-MERVRLEEqerQQQVERLRQQEEERKRK------KLELEKEKRDRKRAEEQRRKILEKELEERKQAM 508

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720388715  985 RYKERDKRKDKAQLNTLIRLKSETEKLKPKLSPASKDTRPKEKRLVNDDLMQTSFER 1041
Cdd:pfam17380  509 IEEERKRKLLEKEMEERQKAIYEEERRREAEEERRKQQEMEERRRIQEQMRKATEER 565
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 155-268 1.10e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 43.80  E-value: 1.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  155 INKRNERGETPLhMAAIR-GDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILI------------------ 215
Cdd:PHA02874    28 INISVDETTTPL-IDAIRsGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIdngvdtsilpipciekdm 106

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720388715  216 -----AAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVA 268
Cdd:PHA02874   107 iktilDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIA 164
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 818-942 1.27e-03

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 43.75  E-value: 1.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  818 EREKL-DFSDCTDRVREKDKLySHQTERCHKDSEKLKNTvRKTDDRERNREKADRKHDREKPERERYLAENKEK-HLEKR 895
Cdd:TIGR01622    6 ERERLrDSSSAGDRDRRRDKG-RERSRDRSRDRERSRSR-RRDRHRDRDYYRGRERRSRSRRPNRRYRPREKRRrRGDSY 83

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1720388715  896 KQSDSSEYSKSEKVRTKDRDREGEKKEKlRDKESVNVTNLKHLQEER 942
Cdd:TIGR01622   84 RRRRDDRRSRREKPRARDGTPEPLTEDE-RDRRTVFVQQLAARARER 129
Ank_4 pfam13637
Ankyrin repeats (many copies);
155-182 1.38e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.41  E-value: 1.38e-03
                           10        20
                   ....*....|....*....|....*...
gi 1720388715  155 INKRNERGETPLHMAAIRGDVKQVKELI 182
Cdd:pfam13637   27 INAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 162-268 2.25e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 42.67  E-value: 2.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  162 GETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDD-DTPLHDSASSGH 240
Cdd:PHA02875    35 GISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKDgMTPLHLATILKK 114

                           90       100
                   ....*....|....*....|....*...
gi 1720388715  241 RDIVKLLLRHGGNPFQANKHGERPVDVA 268
Cdd:PHA02875   115 LDIMKLLIARGADPDIPNTDKFSPLHLA 142
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 649-1034 3.78e-03

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 42.65  E-value: 3.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  649 KELQRSIEFDREFWKENFFKSDETEDLFLTMEHESIIEKKTKMEKNMKDDRSAKEKHVSKERNFKEEREKTKKENEKSLR 728
Cdd:pfam02463  632 TELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEE 711

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  729 EEKVKDPKEE-KDSVSTEKEAEccsvgVSVSQEAAGLHSSEKEMDAEKQERHTKEREKSDRRFQTKEKELDRNERKFsek 807
Cdd:pfam02463  712 LKKLKLEAEElLADRVQEAQDK-----INEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKT--- 783

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  808 ekKIKHEHKSEREKLDFSDCTDRVREKDKLYSHQTErchkdseklkntvrKTDDRERNREKADRKHDREKPERERYLAEN 887
Cdd:pfam02463  784 --EKLKVEEEKEEKLKAQEEELRALEEELKEEAELL--------------EEEQLLIEQEEKIKEEELEELALELKEEQK 847

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720388715  888 KEKHLEKRKQSDSSEYSKSEKVRTKDRDREGEKKEKLRDKESVNVTNLKH-LQEERKSSTGDSSGKTQHEKALSLKERAR 966
Cdd:pfam02463  848 LEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEeKKELEEESQKLNLLEEKENEIEERIKEEA 927

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720388715  967 DEPLKTPDGKEKDKKDIDRYKERDKRKDKAQLNTLIRLKSETEKLKPKLSPASKDTRPKEKRLVNDDL 1034
Cdd:pfam02463  928 EILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDEL 995
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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