BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720387360  305 SLGLLVTDFGAMVNNPHLSDVQFQLDSGEVLYAHKFVLYARCPLLIQYVSTESFSSEEDG-DLTQRALLSDVSSEAAHAF 383
Cdd:cd18288      1 SLGKLAADFSAMVNNPHLSDVQFQTDSGEVLYAHSFVLYARCPLLIQMVHSEGFSVEEEGgVTTRRVLLGDVSGEAARCF 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1720387360  384 LNYLYMADTDMPPSLVPDLRSLALRFGVSDLVQLCE 419
Cdd:cd18288     81 LQYLYTADTGLPPGLSPHVSELADRFGVSELVHLCE 116

Slx4 endonuclease; The Slx4 protein is a heteromeric structure-specific endonuclease found from fungi to mammals. Slx4 with Slx1 acts as a nuclease on branched DNA substrates, particularly simple-Y, 5'-flap, or replication fork structures by cleaving the strand bearing the 5' non-homologous arm at the branch junction and thus generating ligatable nicked products from 5'-flap or replication fork substrates.

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720387360 1344 EEAVRRYIRSKPALHRQVLRYQPVELAELQAELKQNG--IPVAMGKLSDILDAQCITFTT 1401
Cdd:pfam09494    1 FEAITELIKSDPSLYEKILTYEPIVLEDLTAWLNEGGflIEVDPGTLKEWCDSQGICFTN 60

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Structure-specific endonuclease subunit SLX4; SLX4, also called BTB/POZ domain-containing protein 12 (BTBD12), is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases and is required for DNA repair. Mutations of the SLX4 gene are found in Fanconi anemia. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720387360  305 SLGLLVTDFGAMVNNPHLSDVQFQLDSGEVLYAHKFVLYARCPLLIQYVSTESFSSEEDG-DLTQRALLSDVSSEAAHAF 383
Cdd:cd18288      1 SLGKLAADFSAMVNNPHLSDVQFQTDSGEVLYAHSFVLYARCPLLIQMVHSEGFSVEEEGgVTTRRVLLGDVSGEAARCF 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1720387360  384 LNYLYMADTDMPPSLVPDLRSLALRFGVSDLVQLCE 419
Cdd:cd18288     81 LQYLYTADTGLPPGLSPHVSELADRFGVSELVHLCE 116

Slx4 endonuclease; The Slx4 protein is a heteromeric structure-specific endonuclease found from fungi to mammals. Slx4 with Slx1 acts as a nuclease on branched DNA substrates, particularly simple-Y, 5'-flap, or replication fork structures by cleaving the strand bearing the 5' non-homologous arm at the branch junction and thus generating ligatable nicked products from 5'-flap or replication fork substrates.

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720387360 1344 EEAVRRYIRSKPALHRQVLRYQPVELAELQAELKQNG--IPVAMGKLSDILDAQCITFTT 1401
Cdd:pfam09494    1 FEAITELIKSDPSLYEKILTYEPIVLEDLTAWLNEGGflIEVDPGTLKEWCDSQGICFTN 60

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720387360   324 DVQFQLDsGEVLYAHKFVLYARCPLLiqyvsTESFSSEEDGDLTQRALLSDVSSEAAHAFLNYLYMADTDMPPSLVPDLR 403
Cdd:smart00225    1 DVTLVVG-GKKFHAHKAVLAAHSPYF-----KALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELL 74

                            90
                    ....*....|....*..
gi 1720387360   404 SLALRFGVSDLVQLCEQ 420
Cdd:smart00225   75 ELADYLQIPGLVELCEE 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Structure-specific endonuclease subunit SLX4; SLX4, also called BTB/POZ domain-containing protein 12 (BTBD12), is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases and is required for DNA repair. Mutations of the SLX4 gene are found in Fanconi anemia. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720387360  305 SLGLLVTDFGAMVNNPHLSDVQFQLDSGEVLYAHKFVLYARCPLLIQYVSTESFSSEEDG-DLTQRALLSDVSSEAAHAF 383
Cdd:cd18288      1 SLGKLAADFSAMVNNPHLSDVQFQTDSGEVLYAHSFVLYARCPLLIQMVHSEGFSVEEEGgVTTRRVLLGDVSGEAARCF 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1720387360  384 LNYLYMADTDMPPSLVPDLRSLALRFGVSDLVQLCE 419
Cdd:cd18288     81 LQYLYTADTGLPPGLSPHVSELADRFGVSELVHLCE 116

Slx4 endonuclease; The Slx4 protein is a heteromeric structure-specific endonuclease found from fungi to mammals. Slx4 with Slx1 acts as a nuclease on branched DNA substrates, particularly simple-Y, 5'-flap, or replication fork structures by cleaving the strand bearing the 5' non-homologous arm at the branch junction and thus generating ligatable nicked products from 5'-flap or replication fork substrates.

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720387360 1344 EEAVRRYIRSKPALHRQVLRYQPVELAELQAELKQNG--IPVAMGKLSDILDAQCITFTT 1401
Cdd:pfam09494    1 FEAITELIKSDPSLYEKILTYEPIVLEDLTAWLNEGGflIEVDPGTLKEWCDSQGICFTN 60

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720387360  309 LVTDFGAMVNNPHLSDVQFQL-DSGEVLYAHKFVLYARCPLLIQYVSTESFSSEEdgdlTQRALLSDVSSEAAHAFLNYL 387
Cdd:cd18294      1 FAADMKSLINNPEFSDVKFLVgPERQEIFAHKCILAARCEVFRAMFLTGPQKEST----QSPLVLSDIEPEVFRAVLEFI 76

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1720387360  388 YMADTDMPPSLVPDLRSLALRFGVSDLVQLCEQ 420
Cdd:cd18294     77 YTNCVTLSNHTVIEVLAAAVEYGLDELRKLCER 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720387360  322 LSDVQFQLDsGEVLYAHKFVLYARCPLLIQYvstesFSSEEDGDLTQRALLSDVSSEAAHAFLNYLYMADTDMPPSLVPD 401
Cdd:cd18186      1 LCDVTLVVG-GREFPAHRAVLAARSPYFRAM-----FSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEE 74

                   ....*...
gi 1720387360  402 LRSLALRF 409
Cdd:cd18186     75 LLAAADKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720387360  316 MVNNPHLSDVQFQLDsGEVLYAHKFVLYARcplliqyvsTESFSSEEDGDlTQRALLSDVSSEAAHAFLNYLY--MADTD 393
Cdd:cd18303     12 LFDKELYSDITIKLA-DKSIPAHKFVLAAR---------SEKWSNENLAS-TNELDLSDISYEVVLALLRWLYtdELDLT 80

                           90       100
                   ....*....|....*....|....*..
gi 1720387360  394 MPPSLVPDLRSLALRFGVSDLVQLCEQ 420
Cdd:cd18303     81 LDDEFLLELMKAAKRFQLTDLVERCER 107

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720387360  312 DFGAMVNNPHLSDVQFQLDSGEVLYAHKFVLYARCP---LLIqyvstesfsseedGDLTQRALLSDVSSEAAHAFLNYLY 388
Cdd:cd18299      2 DLRNLLHSPSCADVVFILQGGVRIFAHRIVLAAASSvfaDLF-------------LMMTVVTLDSDITPEAFRRVLEFLY 68

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1720387360  389 MADTDMPPSLVPDLRSLALRFGVSDLVQLCEQV 421
Cdd:cd18299     69 TGVLDENEDDLKELKDAAELLELFDLVMMCTNV 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720387360  324 DVQFQLDSGEVlYAHKFVLYARCPLLIqyvstESFSSEEDGDLTQRALLSDVSSEAAHAFLNYLYMADTDMPPSLVPDLR 403
Cdd:cd18306     20 DVILQVGGHEI-PAHRAVLACASPYLF-----ELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTSRLEVPADLVKSVY 93

                           90
                   ....*....|....*..
gi 1720387360  404 SLALRFGVSDLVQLCEQ 420
Cdd:cd18306     94 SAAKKLKMDRVKKACGD 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720387360  318 NNPHLSDVQFQLDsGEVLYAHKFVLYARCplliqyvstESFSS---EEDGDLTQralLSDVSSEAAHAFLNYLYMADTDM 394
Cdd:cd18354     16 DNPDTADLKFLVD-GKYIYVHKVLLKIRC---------EHFRSllnENEEEIIE---MSQFSYPVYRAFLEYLYTDSISL 82

                           90       100
                   ....*....|....*....|....*.
gi 1720387360  395 PPSLVPDLRSLALRFGVSDLVQLCEQ 420
Cdd:cd18354     83 SPEDAIGLLDLATFYRENRLKKLCQQ 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720387360  318 NNPHLSDVQFQLDsGEVLYAHKFVLYARCplliQYVSTeSFSSEEDGDLTQRALLSDVSSEAAHAFLNYLYMADTDMPPS 397
Cdd:cd18298      8 NDPRTSDLKFRVD-GKYIYVHKAILKIRC----EYFRS-MFQSHWNEDDKNVIEIDQYSYPVYYAFLRYLYTDQVDLPPE 81

                           90       100
                   ....*....|....*....|...
gi 1720387360  398 LVPDLRSLALRFGVSDLVQLCEQ 420
Cdd:cd18298     82 DAIGLLDLANSYCEERLKKLCED 104

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720387360  316 MVNNPHLSDVQFQLDSGEVLyAHKFVLYARCPL---LIQYVSTESFSSEedgdltqrALLSDVSSEAAHAFLNYLYMADT 392
Cdd:cd18286     11 LFLNGEDSDITIKVDGKTFK-AHRCILCARSSYfaaMLSGSWAESNSSE--------ITLTGVSHAAVSFVLLFIYGGVL 81

                           90
                   ....*....|....*
gi 1720387360  393 DMPPSLVP-DLRSLA 406
Cdd:cd18286     82 DLPDDVNLgELLSLA 96

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720387360  317 VNNPHLSDVQFQLDsGEVLYAHKFVLYArcplliqyvSTESFSSEEDGDLTQRALLS----DVSSEAAHAFLNYLYMADT 392
Cdd:cd18352      8 VNNATLSDVTFLVE-GRRFYAHRIALLA---------SSDAFRAMFDGGYREKEARDieipNIRWEVFELMMRFIYTGSV 77

                           90       100
                   ....*....|....*....|....*..
gi 1720387360  393 DMPPSLVPDLRSLALRFGVSDLVQLCE 419
Cdd:cd18352     78 DITNDIAKDLLRAADQYLLEGLKRLCE 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720387360  338 HKFVLYARCPLLIQYvstesFSSEEDGDLTQRALLSDVSSEAAHAFLNYLYMADTDMPPSLVPDLRSLALRFGVSDLVQL 417
Cdd:cd18341     42 HRLILAACSPYFREY-----FLSEESEEKKKEVVLDNVDPNIMDMILKYLYSAEIDLNDGNVQDIFALASRFQIPSVFTV 116

                   .
gi 1720387360  418 C 418
Cdd:cd18341    117 C 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720387360  318 NNPHLSDVQFQLDsGEVLYAHKFVLYARCPlliqYVSTE-SFSSEEDGDLTQRALLSDVSSEAAHAFLNYLYMADTDMPP 396
Cdd:cd18245     10 EEPHLCDATLVVG-GEEIPVQKNVLAAASP----YFRAKlNYNPPKDDGSTYKIELEGISVEVMEEILDYIYTGQIKLSE 84

                           90       100
                   ....*....|....*....|..
gi 1720387360  397 SLVPDLRSLALRFGVSDLVQLC 418
Cdd:cd18245     85 DNIQDIVQAADLLLMTDLKDLC 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720387360  309 LVTDFGAMVNNPHLSDVQFQLdSGEVLYAHKFVLYARCPlliqyVSTESFSSEEDGDLTQRALLSDVSSEAAHAFLNYLY 388
Cdd:cd18345      5 LSDDLGLLFERSAFSDVTLCV-GGREFQAHKAILAARSP-----VFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIY 78

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1720387360  389 MADTDMPPSLVPDLRSLALRFGVSDLVQLCEQ 420
Cdd:cd18345     79 TGKAPNLDKMADDLLAAADKYALERLKVMCEE 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720387360  313 FGAMVNNPHLSDVQFQLDSGEV---LYAHKFVLYarcplliqyVSTESFSSEEDGDLTQRAL---LSDVSSEAAHAFLNY 386
Cdd:cd18281     13 FAFLFNNETLSDVHFIVGKGDNeqrIPAHKFVLS---------IGSAVFDAMFNGGMATTSAeieLPDVEPAAFLALLRF 83

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1720387360  387 LYMADTDMPPSLVPDLRSLALRFGVSDLVQLC 418
Cdd:cd18281     84 LYSDEVQIGPETVMTTLYTAKKYAVPALESAC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720387360  308 LLVTDFGAMVNNPHLSDVQFqLDSGEVLYAHKFVLYARCPlliqyVSTESFSSEEDGDLTQRALLSDVSSEAAHAFLNYL 387
Cdd:cd18279      4 RLAEDLGNLWENSRFTDCCL-CVGGQEFQAHKAILAARSP-----VFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFI 77

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1720387360  388 YMADTDMPPSLVPDLRSLALRFGVSDLVQLCEQV 421
Cdd:cd18279     78 YTGKAPNLDKMADDLLAAADKYALERLKVMCEDA 111