|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02885 |
PLN02885 |
nicotinate phosphoribosyltransferase |
2-358 |
7.74e-125 |
|
nicotinate phosphoribosyltransferase
Pssm-ID: 178473 [Multi-domain] Cd Length: 545 Bit Score: 370.14 E-value: 7.74e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 2 GLRRAQGPDGGFTASIYSYLGGFDSSSNTLAGQLRGVPVAGTLAHSFVTSFSGSEVPPDPMLAPASSEGPTVDLPARVNL 81
Cdd:PLN02885 166 GLRRAQGPDGGISASKYCYLGGFDATSNVEAGRLFGIPVRGTHSHAFVSSYMGLDEIVDKTLRSADGSSVCEDFVSLVQE 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 82 WLKRVCLYLGLEEQ--EPHPGERAAFVAYALAFPRAFQGLLDSYSVRRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQ 159
Cdd:PLN02885 246 WLSKLQESSSLRGVfsETNQSELAAFTSYALAFPNSFLALVDTYDVMKSGIPNFCAVALALNDLGYKAVGIRLDSGDLAY 325
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 160 QAKEIRGIFRTAGAQFQMPWLESVPIAVSNNIDESELMRLAQKGSEVNVIGIGTSVVTCPKQPSMGCVYKLVSVGGQPRI 239
Cdd:PLN02885 326 LSLEARKFFRTIEEELGVPGFGKMSITASNDINEETLDALNKQGHEIDAFGIGTHLVTCYAQPALGCVYKLVEINGQPRI 405
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 240 KLTEDPEKQTLPGSKAAFRFLGPDGSLLLDLLQLAEEPPPKAGQelRVW---PRGTQEPCTVKPAQVEPLLRLYLQ--QG 314
Cdd:PLN02885 406 KLSEDVEKVTIPCKKRCYRLYGKEGYPLVDLMTGENEPPPKVGE--RILcrhPFNESKRAYVVPQRVEELLKCYWDgsSG 483
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1720383952 315 QLCEPLPSLDESRRFAQQSLSLLRPAHKQLQSPAVYPVALSEKL 358
Cdd:PLN02885 484 KPREELPSLKEIRERCMKQLERMRPDHMRRLNPTPYKVSVSAKL 527
|
|
| NAPRTase_put |
TIGR01513 |
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ... |
1-358 |
3.07e-117 |
|
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 273666 [Multi-domain] Cd Length: 443 Bit Score: 347.42 E-value: 3.07e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 1 MGLRRAQGPDGGFTASIYSYLGGFDSSSNTLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapassegptvdlparvn 80
Cdd:TIGR01513 150 FGLRRAQGPDAALKAARAAYIGGADGTSNVLAGRLYGIPVSGTMAHSFVMSF---------------------------- 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 81 lwlkrvclylgleeqephPGERAAFVAYALAFPRAFQGLLDSYSVRRSGLPNFLAVALALGELGYrAVGVRLDSGDLLQQ 160
Cdd:TIGR01513 202 ------------------DNELAAFRAYAKLYPKATVLLVDTYDTLRSGLPNAIAVAKELGEQGK-VVGVRIDSGDLLYL 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 161 AKEIRGIFRTAGaqfqmpwLESVPIAVSNNIDESELMRLAQKGSEVNVIGIGTSVVTCPKQPSMGCVYKLVSVGGQPRIK 240
Cdd:TIGR01513 263 SKQARKQLDAAG-------LTQVKIVVSNDLDENSIAALKAEGAPIDVYGVGTSLVTASDAPALGGVYKLVAYEGRPVMK 335
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 241 LTEDPEKQTLPGSKAAFRFLGPDGSLLLDLLQLAEEPPPKAgqelrvwprgTQEPCTVKPAQVEPLLRLYLQQGQLCEPL 320
Cdd:TIGR01513 336 LSENPEKSTLPGRKQVFRLYDATGKFLGDELTLADEPIEDL----------NQEKCTPVFAPVEPLLRLVMKNGQRVRPL 405
|
330 340 350
....*....|....*....|....*....|....*...
gi 1720383952 321 PSLDESRRFAQQSLSLLRPAHKQLQSPAVYPVALSEKL 358
Cdd:TIGR01513 406 PSLAEIRARAREQLSKLPPEYLRLLNPHVYPVSLSPRL 443
|
|
| NAPRTase_A |
cd01570 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ... |
1-231 |
5.63e-79 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).
Pssm-ID: 238804 [Multi-domain] Cd Length: 327 Bit Score: 245.18 E-value: 5.63e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 1 MGLRRAQGPDGGFTASIYSYLGGFDSSSNTLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapassegptvdlparvn 80
Cdd:cd01570 150 FGLRRAQGPDAALSAARAAYIGGFDGTSNVLAGKLYGIPVSGTMAHSFVQAF---------------------------- 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 81 lwlkrvclylgleeqephPGERAAFVAYALAFPRAFQGLLDSYSVRRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQ 160
Cdd:cd01570 202 ------------------DDELAAFRAFAEAYPDNFTLLVDTYDTLRSGLPNAIAVAKELGALGYRLVGVRIDSGDLAYL 263
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720383952 161 AKEIRGIFRTAGaqfqmpwLESVPIAVSNNIDESELMRLAQKGSEVNVIGIGTSVVTCPKQPSMGCVYKLV 231
Cdd:cd01570 264 SKEARKMLDEAG-------LTKVKIVASNDLDEYTIAALNAQGAPIDAFGVGTRLVTSQSQPALGGVYKLV 327
|
|
| PncB |
COG1488 |
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ... |
1-365 |
5.53e-72 |
|
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 441097 [Multi-domain] Cd Length: 445 Bit Score: 231.19 E-value: 5.53e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 1 MGLRRAQGPDGGFTASIYSYLGGFDSSSNTLAGQLRGVPVAGTLAHSFVTSfsgsevppdpmlapassegptvdlparvn 80
Cdd:COG1488 154 FGLRRAHGLEAAVAAARAAYLAGFAGTSNVLAGRYYGIPSVGTMAHSFVQA----------------------------- 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 81 lwlkrvclylgleeqepHPGERAAFVAYALAFPRAFQGLLDSYSVRrSGLPNflAVALAlGELG--YRAVGVRLDSGDLL 158
Cdd:COG1488 205 -----------------HDDELEAFRAFAEAYPDGTTLLVDTYDTL-SGVPN--AIELA-KELLarGGLLGIRLDSGDLA 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 159 QQAKEIRGIFRTAGaqfqmpwLESVPIAVSNNIDESELMRLAQKGSEVNVIGIGTSVVTCPKQPSMGCVYKLVSVGG--- 235
Cdd:COG1488 264 YLSKQARELLDEAG-------LPDVRIIASDDLDEYRIAALLEQGAPIDVFGVGTRLVTSSDRPTLGFVYKLVAVEGdge 336
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 236 -QPRIKLTEDPEKQTLPGSKAAFRFlGPDGSLLLDLLQLAEEPPpkagqelrvwprgtqepctvkPAQVEPLLRLYLQQG 314
Cdd:COG1488 337 wRPVIKLSETPGKKSKPGRKQVYRR-DEDGKATADLVALEDEPL---------------------PGEPEPLLVPVFRDG 394
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1720383952 315 QLCEPLPSLDESRRFAQQSLSLLRPAHKQLQSPAVYPVALSEKLRALVDSL 365
Cdd:COG1488 395 KLVYELPSLEEIRERAAAQLAELPEELKRLRNPPAYPVDLSEALWDLKEQL 445
|
|
| NAPRTase_C |
pfam17956 |
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus ... |
254-361 |
8.63e-30 |
|
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus of some Nicotinate phosphoribosyltransferase enzymes. The function of this domain is uncertain.
Pssm-ID: 465585 [Multi-domain] Cd Length: 111 Bit Score: 110.73 E-value: 8.63e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 254 KAAFRFLGPDGSLLLDLLQLAEEPPPKAGQELRVW-PRGTQEPCTVKPAQVEPLLRLYLQQGQLCEPLPSLDESRRFAQQ 332
Cdd:pfam17956 2 KQVYRLYDKDGKAIADLITLADEPPPDPGEEILCFhPFDEWKRKTVTPFTVEPLLKPVFEDGKLVYELPTLEEIRAYVQE 81
|
90 100
....*....|....*....|....*....
gi 1720383952 333 SLSLLRPAHKQLQSPAVYPVALSEKLRAL 361
Cdd:pfam17956 82 QLSRLWPEHKRLLNPHPYKVDLSEKLYQL 110
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02885 |
PLN02885 |
nicotinate phosphoribosyltransferase |
2-358 |
7.74e-125 |
|
nicotinate phosphoribosyltransferase
Pssm-ID: 178473 [Multi-domain] Cd Length: 545 Bit Score: 370.14 E-value: 7.74e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 2 GLRRAQGPDGGFTASIYSYLGGFDSSSNTLAGQLRGVPVAGTLAHSFVTSFSGSEVPPDPMLAPASSEGPTVDLPARVNL 81
Cdd:PLN02885 166 GLRRAQGPDGGISASKYCYLGGFDATSNVEAGRLFGIPVRGTHSHAFVSSYMGLDEIVDKTLRSADGSSVCEDFVSLVQE 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 82 WLKRVCLYLGLEEQ--EPHPGERAAFVAYALAFPRAFQGLLDSYSVRRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQ 159
Cdd:PLN02885 246 WLSKLQESSSLRGVfsETNQSELAAFTSYALAFPNSFLALVDTYDVMKSGIPNFCAVALALNDLGYKAVGIRLDSGDLAY 325
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 160 QAKEIRGIFRTAGAQFQMPWLESVPIAVSNNIDESELMRLAQKGSEVNVIGIGTSVVTCPKQPSMGCVYKLVSVGGQPRI 239
Cdd:PLN02885 326 LSLEARKFFRTIEEELGVPGFGKMSITASNDINEETLDALNKQGHEIDAFGIGTHLVTCYAQPALGCVYKLVEINGQPRI 405
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 240 KLTEDPEKQTLPGSKAAFRFLGPDGSLLLDLLQLAEEPPPKAGQelRVW---PRGTQEPCTVKPAQVEPLLRLYLQ--QG 314
Cdd:PLN02885 406 KLSEDVEKVTIPCKKRCYRLYGKEGYPLVDLMTGENEPPPKVGE--RILcrhPFNESKRAYVVPQRVEELLKCYWDgsSG 483
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1720383952 315 QLCEPLPSLDESRRFAQQSLSLLRPAHKQLQSPAVYPVALSEKL 358
Cdd:PLN02885 484 KPREELPSLKEIRERCMKQLERMRPDHMRRLNPTPYKVSVSAKL 527
|
|
| NAPRTase_put |
TIGR01513 |
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ... |
1-358 |
3.07e-117 |
|
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 273666 [Multi-domain] Cd Length: 443 Bit Score: 347.42 E-value: 3.07e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 1 MGLRRAQGPDGGFTASIYSYLGGFDSSSNTLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapassegptvdlparvn 80
Cdd:TIGR01513 150 FGLRRAQGPDAALKAARAAYIGGADGTSNVLAGRLYGIPVSGTMAHSFVMSF---------------------------- 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 81 lwlkrvclylgleeqephPGERAAFVAYALAFPRAFQGLLDSYSVRRSGLPNFLAVALALGELGYrAVGVRLDSGDLLQQ 160
Cdd:TIGR01513 202 ------------------DNELAAFRAYAKLYPKATVLLVDTYDTLRSGLPNAIAVAKELGEQGK-VVGVRIDSGDLLYL 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 161 AKEIRGIFRTAGaqfqmpwLESVPIAVSNNIDESELMRLAQKGSEVNVIGIGTSVVTCPKQPSMGCVYKLVSVGGQPRIK 240
Cdd:TIGR01513 263 SKQARKQLDAAG-------LTQVKIVVSNDLDENSIAALKAEGAPIDVYGVGTSLVTASDAPALGGVYKLVAYEGRPVMK 335
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 241 LTEDPEKQTLPGSKAAFRFLGPDGSLLLDLLQLAEEPPPKAgqelrvwprgTQEPCTVKPAQVEPLLRLYLQQGQLCEPL 320
Cdd:TIGR01513 336 LSENPEKSTLPGRKQVFRLYDATGKFLGDELTLADEPIEDL----------NQEKCTPVFAPVEPLLRLVMKNGQRVRPL 405
|
330 340 350
....*....|....*....|....*....|....*...
gi 1720383952 321 PSLDESRRFAQQSLSLLRPAHKQLQSPAVYPVALSEKL 358
Cdd:TIGR01513 406 PSLAEIRARAREQLSKLPPEYLRLLNPHVYPVSLSPRL 443
|
|
| PRK09243 |
PRK09243 |
nicotinate phosphoribosyltransferase; Validated |
1-358 |
9.59e-90 |
|
nicotinate phosphoribosyltransferase; Validated
Pssm-ID: 236426 [Multi-domain] Cd Length: 464 Bit Score: 277.42 E-value: 9.59e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 1 MGLRRAQGPDGGFTASIYSYLGGFDSSSNTLAGQLRGVPVAGTLAHSFVTSfsgsevppdpmlapassegptvdlparvn 80
Cdd:PRK09243 159 FGSRRAQGPDAAVWAARAAYIGGFDATSNVLAGKRYGIPVSGTMAHSFVQA----------------------------- 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 81 lwlkrvclylgleeqepHPGERAAFVAYALAFPRAFQGLLDSYSVRRSGLPNflAVALAlGEL--GYRAVGVRLDSGDLL 158
Cdd:PRK09243 210 -----------------FDDEYEAFRAYAETYPDNTVLLVDTYDTLKSGVPN--AIKVA-KELgdGIELGGVRIDSGDLA 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 159 QQAKEIRGIFRTAGaqfqmpwLESVPIAVSNNIDESELMRLAQKGSEVNVIGIGTSVVTCPKQPSMGCVYKLVSVGG--- 235
Cdd:PRK09243 270 YLSKKVRKMLDEAG-------FTDTKIVASNDLDEYTIASLKLQGAPIDGFGVGTKLVTGSDAPALGGVYKLVAIEGegg 342
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 236 -QPRIKLTEDPEKQTLPGSKAAFRFLGPDGSLLLDLLQLAEEPPPKAGqeLRVWPRGTQEPCTVKPAQVEPLLRLYLQQG 314
Cdd:PRK09243 343 mIPKIKLSNSPEKVTTPGRKQVYRIYDKGGKAEADVITLADEEEEEPL--KMFHPVHTYKSKTVKNFDAEPLLVPVMENG 420
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1720383952 315 QLCEPLPSLDESRRFAQQSLSLLRPAHKQLQSPAVYPVALSEKL 358
Cdd:PRK09243 421 KRVYELPSLEEIRAYAAAQLASLPEEYKRLLNPHAYPVDLSQAL 464
|
|
| NAPRTase_A |
cd01570 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ... |
1-231 |
5.63e-79 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).
Pssm-ID: 238804 [Multi-domain] Cd Length: 327 Bit Score: 245.18 E-value: 5.63e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 1 MGLRRAQGPDGGFTASIYSYLGGFDSSSNTLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapassegptvdlparvn 80
Cdd:cd01570 150 FGLRRAQGPDAALSAARAAYIGGFDGTSNVLAGKLYGIPVSGTMAHSFVQAF---------------------------- 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 81 lwlkrvclylgleeqephPGERAAFVAYALAFPRAFQGLLDSYSVRRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQ 160
Cdd:cd01570 202 ------------------DDELAAFRAFAEAYPDNFTLLVDTYDTLRSGLPNAIAVAKELGALGYRLVGVRIDSGDLAYL 263
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720383952 161 AKEIRGIFRTAGaqfqmpwLESVPIAVSNNIDESELMRLAQKGSEVNVIGIGTSVVTCPKQPSMGCVYKLV 231
Cdd:cd01570 264 SKEARKMLDEAG-------LTKVKIVASNDLDEYTIAALNAQGAPIDAFGVGTRLVTSQSQPALGGVYKLV 327
|
|
| PncB |
COG1488 |
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ... |
1-365 |
5.53e-72 |
|
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 441097 [Multi-domain] Cd Length: 445 Bit Score: 231.19 E-value: 5.53e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 1 MGLRRAQGPDGGFTASIYSYLGGFDSSSNTLAGQLRGVPVAGTLAHSFVTSfsgsevppdpmlapassegptvdlparvn 80
Cdd:COG1488 154 FGLRRAHGLEAAVAAARAAYLAGFAGTSNVLAGRYYGIPSVGTMAHSFVQA----------------------------- 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 81 lwlkrvclylgleeqepHPGERAAFVAYALAFPRAFQGLLDSYSVRrSGLPNflAVALAlGELG--YRAVGVRLDSGDLL 158
Cdd:COG1488 205 -----------------HDDELEAFRAFAEAYPDGTTLLVDTYDTL-SGVPN--AIELA-KELLarGGLLGIRLDSGDLA 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 159 QQAKEIRGIFRTAGaqfqmpwLESVPIAVSNNIDESELMRLAQKGSEVNVIGIGTSVVTCPKQPSMGCVYKLVSVGG--- 235
Cdd:COG1488 264 YLSKQARELLDEAG-------LPDVRIIASDDLDEYRIAALLEQGAPIDVFGVGTRLVTSSDRPTLGFVYKLVAVEGdge 336
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 236 -QPRIKLTEDPEKQTLPGSKAAFRFlGPDGSLLLDLLQLAEEPPpkagqelrvwprgtqepctvkPAQVEPLLRLYLQQG 314
Cdd:COG1488 337 wRPVIKLSETPGKKSKPGRKQVYRR-DEDGKATADLVALEDEPL---------------------PGEPEPLLVPVFRDG 394
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1720383952 315 QLCEPLPSLDESRRFAQQSLSLLRPAHKQLQSPAVYPVALSEKLRALVDSL 365
Cdd:COG1488 395 KLVYELPSLEEIRERAAAQLAELPEELKRLRNPPAYPVDLSEALWDLKEQL 445
|
|
| PRK12484 |
PRK12484 |
nicotinate phosphoribosyltransferase; Provisional |
2-368 |
9.89e-54 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 237112 [Multi-domain] Cd Length: 443 Bit Score: 183.41 E-value: 9.89e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 2 GLRRAQGPDGGFTASIYSYLGGFDSSSNTLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapassegptvdlparvnl 81
Cdd:PRK12484 154 GARRAHGTDAACYVARASYLAGAAGTSNVLAARQYGIPASGTMAHSFVEAF----------------------------- 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 82 wlkrvclylgleeqephPGERAAFVAYALAFPRAFQGLLDSYSVRRsGLPNFLAVALALGElGYRAVGVRLDSGDLLQQA 161
Cdd:PRK12484 205 -----------------PDEVAAFRAFARLYPDATTLLVDTYDTLR-GVRNAIEVAKELGN-RFDPRGVRLDSGDLAELS 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 162 KEIRGIFRTAGaqfqmpwLESVPIAVSNNIDESELMRLAQKGSEVNVIGIGTSVVTCPKQPSMGCVYKLVSVGGQPRIKL 241
Cdd:PRK12484 266 KATRAILDAAG-------LEQVKIVASGGLDEYRIAALLAAGAPIDGFGVGTRLGVAADAPVLDSAYKLVAYEGRGVTKL 338
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 242 TedPEKQTLPGSKAAFRFLGPDGSLLLDLLQLAEEPPPKAgqelrvwprgtqepctvkpaqvEPLLRLYLQQGQLCEPLP 321
Cdd:PRK12484 339 S--SGKVTYPGRKQVFRLYEHGTACGDVIGLHTENIPDGR----------------------EPLLVPVMTNGRRIQHAP 394
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1720383952 322 SLDESRRFAQQSLSLLRPAHKQLQSPAVYPVALSEKLRALVDSLSAR 368
Cdd:PRK12484 395 TLDGARDWCEAQLAALPPEARRLVDPVAVSVTLSGELARLRHADTAE 441
|
|
| NAPRTase_PncB |
cd01567 |
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase ... |
1-229 |
1.32e-37 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.
Pssm-ID: 238801 [Multi-domain] Cd Length: 343 Bit Score: 138.17 E-value: 1.32e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 1 MGLRRAQGPDGGFTASIYSYLGGFDSSSNTLAGQLRGVPVAGTLAHSFVTSFSGSEVppdpmlapassegptvdlparvn 80
Cdd:cd01567 161 FGTRRRHSPEAALSGGRAALIGGFGGTSNVAAAKKLGIPPIGTMAHSWIQAFGALEE----------------------- 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 81 lwlkrvclylgleeqephpgerAAFVAYALAFPRAFQGLL----DSYSVRRsGLPNFLAVALALGElGYRAVGVRLDSGD 156
Cdd:cd01567 218 ----------------------AAFEAFARWLPQFGGGLGialiDTYDTDN-GFLNALKLAKALGA-GGGLLGVRLDSGD 273
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720383952 157 LLQQAKEIRGIFRTAGAqfqmpWLESVPIAVSNNIDESELMR--LAQKGSEVNVIGIGTSVVTCPKQPSMGCVYK 229
Cdd:cd01567 274 PVELIKKVRKHLDELGI-----DLNKKKIIISGDLDTEEAIEllLEQGASPNDAFGVGTSLTNDLGRPPLGFVYK 343
|
|
| NAPRTase_C |
pfam17956 |
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus ... |
254-361 |
8.63e-30 |
|
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus of some Nicotinate phosphoribosyltransferase enzymes. The function of this domain is uncertain.
Pssm-ID: 465585 [Multi-domain] Cd Length: 111 Bit Score: 110.73 E-value: 8.63e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 254 KAAFRFLGPDGSLLLDLLQLAEEPPPKAGQELRVW-PRGTQEPCTVKPAQVEPLLRLYLQQGQLCEPLPSLDESRRFAQQ 332
Cdd:pfam17956 2 KQVYRLYDKDGKAIADLITLADEPPPDPGEEILCFhPFDEWKRKTVTPFTVEPLLKPVFEDGKLVYELPTLEEIRAYVQE 81
|
90 100
....*....|....*....|....*....
gi 1720383952 333 SLSLLRPAHKQLQSPAVYPVALSEKLRAL 361
Cdd:pfam17956 82 QLSRLWPEHKRLLNPHPYKVDLSEKLYQL 110
|
|
| PRTase_typeII |
cd00516 |
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an ... |
1-229 |
8.89e-19 |
|
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate phosphoribosyltransferase (NAPRTase), to be used in the synthesis of NAD. QAPRTase catalyses the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide, an important step in the de novo synthesis of NAD. NAPRTase catalyses a similar reaction leading to NAMN and pyrophosphate, using nicotinic acid an PPRP as substrates, used in the NAD salvage pathway.
Pssm-ID: 238286 [Multi-domain] Cd Length: 281 Bit Score: 85.37 E-value: 8.89e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 1 MGLRRAQgPDGGFTASIYSYLGGFDSSSNTLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapassegptvdlparvn 80
Cdd:cd00516 116 FGTRKTT-PGLRLLEKYAVLIGGGDGHRNGLSDAILIKDNHGTMAHSIIQAF---------------------------- 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 81 lwlkrvclylgleeqephpGERAAFVAYALAFPRAFQGLLDSYSvrrSGLPNFLAVALALgelgyRAVGVRLDSG----- 155
Cdd:cd00516 167 -------------------GELAAVKALRRWLPELFIALIDVEV---DTLEEALEAAKAG-----GADGIRLDSGspeel 219
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720383952 156 DLLQQAKEIRGIFRTAGaqfqmpwLESVPIAVSNNIDESELMRLAQKGseVNVIGIGTSVVTCpkqPSMGCVYK 229
Cdd:cd00516 220 DPAVLILKARAHLDGKG-------LPRVKIEASGGLDEENIRAYAETG--VDVFGVGTLLHSA---PPLDIVLK 281
|
|
| PncB_like |
cd01401 |
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate ... |
148-249 |
6.88e-03 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria, archea and funghi.
Pssm-ID: 238695 [Multi-domain] Cd Length: 377 Bit Score: 38.00 E-value: 6.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383952 148 VGVRLDSGDLLQQAKEIRGifrtagaqfqmpWLESVPIA-------VSNNIDES---ELMRLAQKGseVNVI-GIGTS-- 214
Cdd:cd01401 275 DGVRHDSGDPFEWGEKAIA------------HYEKLGIDpktktlvFSDGLDVEkalELYEYFKGR--IKVSfGIGTNlt 340
|
90 100 110
....*....|....*....|....*....|....*..
gi 1720383952 215 --VVTCPKQPSMGCVYKLVSVGGQPRIKLTEDPEKQT 249
Cdd:cd01401 341 ndFGNKEKSTPLNIVIKLVECNGRPVAKISDSPGKNM 377
|
|
| PRK05321 |
PRK05321 |
nicotinate phosphoribosyltransferase; Provisional |
206-249 |
9.99e-03 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 235406 [Multi-domain] Cd Length: 400 Bit Score: 37.82 E-value: 9.99e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1720383952 206 VNVI-GIGTSVvTC--PKQPSMGCVYKLVSVGGQPRIKLTEDPEKQT 249
Cdd:PRK05321 332 IKLSfGIGTNL-TNdfPGVKPLNIVIKLVECNGRPVAKLSDSPGKTM 377
|
|
| |
