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Conserved domains on  [gi|1720380237|ref|XP_030103759|]
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actin-related protein 8 isoform X5 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ASKHA_NBD_Arp8-like cd10206
nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The ...
 1-369 8.59e-141

nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The Arp8-like family includes Arp8, also called actin-like protein 8, from vertebrates and fungi. Human Arp8 is encoded by the ACTR8 gene and is also known as INO80 complex subunit N. It plays an important role in the functional organization of mitotic chromosomes. Arp8 exhibits low basal ATPase activity, and is unable to polymerize. It is probably a core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication, and probably DNA repair. it is required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Arp8 strongly prefers nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex. This subfamily also contains Arabidopsis thaliana Arp9.


:

Pssm-ID: 466812 [Multi-domain]  Cd Length: 447  Bit Score: 407.40  E-value: 8.59e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237   1 MILMKMGFAGIVVHQESVCATFGSGLSSTCVVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAGFPYR 80
Cdd:cd10206   207 LLLRRLGFSSVFVHQESVCATFGAGLSSACVVDIGAQKTSVACVEDGLSIPNSRIRLPYGGDDITRCFLWLLRRSGFPYR 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237  81 ECQLTNKMDCLLLQHLKETFCHLDQDISGLQDHEFQIRHPDSPALLYQFRLgdeklqapmalfypatfgivgqkmttlqh 160
Cdd:cd10206   287 ECNLNSPLDFLLLERLKETYCTLDQDDIGVQLHEFYVREPGQPTLKYQFKL----------------------------- 337

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237 161 rsqgdpedphdehyllatqskqeqsakatadrksaskpigfegdlrgqssdlperlhsqevdlassqgdclmagneseea 240
Cdd:cd10206       --------------------------------------------------------------------------------

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237 241 ltalmsrktaislfegkaLGLDKAILHSVDCCSSDDTKKKMYSSILVVGGGLMFHKAQEFLQHRILNKMPPSFrRIIENV 320
Cdd:cd10206   338 ------------------LPLDEAIVQSILSCASDELKRKMYSSILLVGGGAKIPGLAEALEDRLLIKIPSLF-EAVETV 398

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1720380237 321 DVITRPKDMDPRLIAWKGGAVLACLDTTQELWIYQREWQRFGVRMLRER 369
Cdd:cd10206   399 EVLPPPKDMDPSLLAWKGGAVLACLDSAQELWITRKEWQRLGVRALRER 447
 
Name Accession Description Interval E-value
ASKHA_NBD_Arp8-like cd10206
nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The ...
 1-369 8.59e-141

nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The Arp8-like family includes Arp8, also called actin-like protein 8, from vertebrates and fungi. Human Arp8 is encoded by the ACTR8 gene and is also known as INO80 complex subunit N. It plays an important role in the functional organization of mitotic chromosomes. Arp8 exhibits low basal ATPase activity, and is unable to polymerize. It is probably a core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication, and probably DNA repair. it is required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Arp8 strongly prefers nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex. This subfamily also contains Arabidopsis thaliana Arp9.


Pssm-ID: 466812 [Multi-domain]  Cd Length: 447  Bit Score: 407.40  E-value: 8.59e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237   1 MILMKMGFAGIVVHQESVCATFGSGLSSTCVVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAGFPYR 80
Cdd:cd10206   207 LLLRRLGFSSVFVHQESVCATFGAGLSSACVVDIGAQKTSVACVEDGLSIPNSRIRLPYGGDDITRCFLWLLRRSGFPYR 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237  81 ECQLTNKMDCLLLQHLKETFCHLDQDISGLQDHEFQIRHPDSPALLYQFRLgdeklqapmalfypatfgivgqkmttlqh 160
Cdd:cd10206   287 ECNLNSPLDFLLLERLKETYCTLDQDDIGVQLHEFYVREPGQPTLKYQFKL----------------------------- 337

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237 161 rsqgdpedphdehyllatqskqeqsakatadrksaskpigfegdlrgqssdlperlhsqevdlassqgdclmagneseea 240
Cdd:cd10206       --------------------------------------------------------------------------------

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237 241 ltalmsrktaislfegkaLGLDKAILHSVDCCSSDDTKKKMYSSILVVGGGLMFHKAQEFLQHRILNKMPPSFrRIIENV 320
Cdd:cd10206   338 ------------------LPLDEAIVQSILSCASDELKRKMYSSILLVGGGAKIPGLAEALEDRLLIKIPSLF-EAVETV 398

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1720380237 321 DVITRPKDMDPRLIAWKGGAVLACLDTTQELWIYQREWQRFGVRMLRER 369
Cdd:cd10206   399 EVLPPPKDMDPSLLAWKGGAVLACLDSAQELWITRKEWQRLGVRALRER 447
ACTIN smart00268
Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily
 5-369 8.36e-16

Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily


Pssm-ID: 214592 [Multi-domain]  Cd Length: 373  Bit Score: 78.07  E-value: 8.36e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237    5 KMGFAGIVVHQESVCATFGSGLSSTCVVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRcfywLMQRAgFPYRECQL 84
Cdd:smart00268 121 TFNFPALYIAIQAVLSLYASGRTTGLVIDSGDGVTHVVPVVDGYVLPHAIKRIDIAGRDITD----YLKEL-LSERGYQF 195

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237   85 TNKMDCLLLQHLKETFCHLDQDIsglqDHEFQIRHPDSPALL----YQF------RLGDEKLQAPMALFYPatfgivgqk 154
Cdd:smart00268 196 NSSAEFEIVREIKEKLCYVAEDF----EKEMKLARESSESSKlektYELpdgntiKVGNERFRIPEILFSP--------- 262

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237  155 mttlqhrsqgdpedphdehyllatqskqeqsakatadrksasKPIGFEGDlrgqssdlperlhsqevdlassqgdclmag 234
Cdd:smart00268 263 ------------------------------------------ELIGLEQK------------------------------ 270

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237  235 neseealtalmsrktaislfegkalGLDKAILHSVDCCSSDdTKKKMYSSILVVGGGLMFHKAQEFLQHRILNKMPPSFR 314
Cdd:smart00268 271 -------------------------GIHELVYESIQKCDID-VRKDLYENIVLSGGSTLIPGFGERLEKELKQLAPKKLK 324

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1720380237  315 riienVDVITRPkdmDPRLIAWKGGAVLACLDTTQELWIYQREWQRFGVRMLRER 369
Cdd:smart00268 325 -----VKVIAPP---ERKYSVWLGGSILASLSTFEDMWITKKEYEESGSQIVERK 371
Actin pfam00022
Actin;
18-364 1.08e-13

Actin;


Pssm-ID: 394979 [Multi-domain]  Cd Length: 407  Bit Score: 71.95  E-value: 1.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237  18 VCATFGSGLSSTCVVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAGFPYRECQLTNKMDCLllqhlk 97
Cdd:pfam00022 132 VLSAFASGRTTGLVVDSGAGVTSVVPVHDGYVLQKAIRRSDLGGDFLTDYLRELLRSRNIEITPRYLIKSKKPG------ 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237  98 etfchldqdisglqDHEFQIRHPDSPALLYQFRLGDEKlqapmalfypatfGIVGQ-KMTTLQHrsqgdPEDPHdehyll 176
Cdd:pfam00022 206 --------------DPAPAVTKRELPDTTYSYKTYQER-------------RVLEEiKESVCYV-----SDDPF------ 247

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237 177 atqsKQEQSAKATADRksaskpiGFEgdlrgqssdLPErlhsqevdlassqGDCLMAGNE----SEEALTALMSRKTAIS 252
Cdd:pfam00022 248 ----GDETTSSSIPTR-------VYE---------LPD-------------GSTIILGAErfrvPEILFNPSLIGSESEL 294

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237 253 LFEGKALGLDKAILHSVDCCSSDdTKKKMYSSILVVGGGLMFHKAQEFLQHRILNKMPPSFRriienVDVITRPKDMDPR 332
Cdd:pfam00022 295 PPPQTAVGIPELIVDAINACDVD-LRPSLLANIVVTGGNSLFPGFTERLEKELAQLAPPGVK-----VKIIAPGNTVERR 368

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1720380237 333 LIAWKGGAVLACLDTTQELWIYQREWQRFGVR 364
Cdd:pfam00022 369 YSAWIGGSILASLGTFQQMWVSKQEYEEHGAS 400
PTZ00466 PTZ00466
actin-like protein; Provisional
 259-370 1.01e-07

actin-like protein; Provisional


Pssm-ID: 240426 [Multi-domain]  Cd Length: 380  Bit Score: 53.41  E-value: 1.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237 259 LGLDKAILHSVDCCSSDdTKKKMYSSILVVGGGLMFHKAQEflqhRILNKMppsfRRIIenvdvitrPKDMDPRLIA--- 335
Cdd:PTZ00466  277 LGLSELIVTSITRADMD-LRRTLYSHIVLSGGTTMFHGFGD----RLLNEI----RKFA--------PKDITIRISAppe 339

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1720380237 336 -----WKGGAVLACLDTTQELWIYQREWQRFGVRMLRERA 370
Cdd:PTZ00466  340 rkfstFIGGSILASLATFKKIWISKQEFDEYGSVILHRKT 379
 
Name Accession Description Interval E-value
ASKHA_NBD_Arp8-like cd10206
nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The ...
 1-369 8.59e-141

nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The Arp8-like family includes Arp8, also called actin-like protein 8, from vertebrates and fungi. Human Arp8 is encoded by the ACTR8 gene and is also known as INO80 complex subunit N. It plays an important role in the functional organization of mitotic chromosomes. Arp8 exhibits low basal ATPase activity, and is unable to polymerize. It is probably a core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication, and probably DNA repair. it is required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Arp8 strongly prefers nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex. This subfamily also contains Arabidopsis thaliana Arp9.


Pssm-ID: 466812 [Multi-domain]  Cd Length: 447  Bit Score: 407.40  E-value: 8.59e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237   1 MILMKMGFAGIVVHQESVCATFGSGLSSTCVVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAGFPYR 80
Cdd:cd10206   207 LLLRRLGFSSVFVHQESVCATFGAGLSSACVVDIGAQKTSVACVEDGLSIPNSRIRLPYGGDDITRCFLWLLRRSGFPYR 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237  81 ECQLTNKMDCLLLQHLKETFCHLDQDISGLQDHEFQIRHPDSPALLYQFRLgdeklqapmalfypatfgivgqkmttlqh 160
Cdd:cd10206   287 ECNLNSPLDFLLLERLKETYCTLDQDDIGVQLHEFYVREPGQPTLKYQFKL----------------------------- 337

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237 161 rsqgdpedphdehyllatqskqeqsakatadrksaskpigfegdlrgqssdlperlhsqevdlassqgdclmagneseea 240
Cdd:cd10206       --------------------------------------------------------------------------------

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237 241 ltalmsrktaislfegkaLGLDKAILHSVDCCSSDDTKKKMYSSILVVGGGLMFHKAQEFLQHRILNKMPPSFrRIIENV 320
Cdd:cd10206   338 ------------------LPLDEAIVQSILSCASDELKRKMYSSILLVGGGAKIPGLAEALEDRLLIKIPSLF-EAVETV 398

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1720380237 321 DVITRPKDMDPRLIAWKGGAVLACLDTTQELWIYQREWQRFGVRMLRER 369
Cdd:cd10206   399 EVLPPPKDMDPSLLAWKGGAVLACLDSAQELWITRKEWQRLGVRALRER 447
ASKHA_NBD_actin-like cd10169
nucleotide-binding domain (NBD) of actin and actin-related proteins (ARPs); Actin is ...
 1-362 4.07e-24

nucleotide-binding domain (NBD) of actin and actin-related proteins (ARPs); Actin is ubiquitous in eukaryotes, and the major component of the actin cytoskeleton; monomeric globular protein (G-actin) reversibly polymerizes to form filaments (F-actin). Each actin protomer binds one molecule of ATP and either calcium or magnesium ions. F-actin filaments form with the consequent hydrolysis of ATP. Some actin-related proteins (Arps) have roles in cytoskeletal functions, such as actin polymerization (Arp2/3) and dynein motor activity (Arp1). Both conventional actin and specific Arps have been implicated in chromatin remodeling and/or transcription regulation. The actin/ARP family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466810 [Multi-domain]  Cd Length: 258  Bit Score: 99.87  E-value: 4.07e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237   1 MILMKMGFAGIVVHQESVCATFGSGLSSTCVVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAGFPYr 80
Cdd:cd10169    69 ILFETFNVPSLYIANQAVLSLYASGRTTGLVVDSGEGVTHIVPVYEGYVLPHAVRRLDIGGRDLTDYLAKLLREKGYSF- 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237  81 ecqlTNKMDCLLLQHLKETFChldqdisglqdhefqirhpdspallyqfrlgdeklqapmalfypatfgivgqkmttlqh 160
Cdd:cd10169   148 ----STSAEREIVRDIKEKLC----------------------------------------------------------- 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237 161 rsqgdpedphdehyllatqskqeqsakatadrksaskpigfegdlrgqssdlperlhsqevdlassqgdclmagneseea 240
Cdd:cd10169       --------------------------------------------------------------------------------

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237 241 ltalmsrktaislfegkalGLDKAILHSVDCCSsDDTKKKMYSSILVVGGGLMFHKAQEFLQHRILNKMPPSFRriienV 320
Cdd:cd10169   165 -------------------GLHELIYDSIMKCD-IDLRKELYSNIVLSGGTTLFPGFAERLQKELSKLAPSSVK-----V 219

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1720380237 321 DVITRPkdmDPRLIAWKGGAVLACLDTTQELWIYQREWQRFG 362
Cdd:cd10169   220 KVIAPP---ERKYSAWIGGSILASLSTFQQMWITKEEYEEHG 258
ACTIN smart00268
Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily
 5-369 8.36e-16

Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily


Pssm-ID: 214592 [Multi-domain]  Cd Length: 373  Bit Score: 78.07  E-value: 8.36e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237    5 KMGFAGIVVHQESVCATFGSGLSSTCVVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRcfywLMQRAgFPYRECQL 84
Cdd:smart00268 121 TFNFPALYIAIQAVLSLYASGRTTGLVIDSGDGVTHVVPVVDGYVLPHAIKRIDIAGRDITD----YLKEL-LSERGYQF 195

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237   85 TNKMDCLLLQHLKETFCHLDQDIsglqDHEFQIRHPDSPALL----YQF------RLGDEKLQAPMALFYPatfgivgqk 154
Cdd:smart00268 196 NSSAEFEIVREIKEKLCYVAEDF----EKEMKLARESSESSKlektYELpdgntiKVGNERFRIPEILFSP--------- 262

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237  155 mttlqhrsqgdpedphdehyllatqskqeqsakatadrksasKPIGFEGDlrgqssdlperlhsqevdlassqgdclmag 234
Cdd:smart00268 263 ------------------------------------------ELIGLEQK------------------------------ 270

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237  235 neseealtalmsrktaislfegkalGLDKAILHSVDCCSSDdTKKKMYSSILVVGGGLMFHKAQEFLQHRILNKMPPSFR 314
Cdd:smart00268 271 -------------------------GIHELVYESIQKCDID-VRKDLYENIVLSGGSTLIPGFGERLEKELKQLAPKKLK 324

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1720380237  315 riienVDVITRPkdmDPRLIAWKGGAVLACLDTTQELWIYQREWQRFGVRMLRER 369
Cdd:smart00268 325 -----VKVIAPP---ERKYSVWLGGSILASLSTFEDMWITKKEYEESGSQIVERK 371
Actin pfam00022
Actin;
18-364 1.08e-13

Actin;


Pssm-ID: 394979 [Multi-domain]  Cd Length: 407  Bit Score: 71.95  E-value: 1.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237  18 VCATFGSGLSSTCVVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAGFPYRECQLTNKMDCLllqhlk 97
Cdd:pfam00022 132 VLSAFASGRTTGLVVDSGAGVTSVVPVHDGYVLQKAIRRSDLGGDFLTDYLRELLRSRNIEITPRYLIKSKKPG------ 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237  98 etfchldqdisglqDHEFQIRHPDSPALLYQFRLGDEKlqapmalfypatfGIVGQ-KMTTLQHrsqgdPEDPHdehyll 176
Cdd:pfam00022 206 --------------DPAPAVTKRELPDTTYSYKTYQER-------------RVLEEiKESVCYV-----SDDPF------ 247

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237 177 atqsKQEQSAKATADRksaskpiGFEgdlrgqssdLPErlhsqevdlassqGDCLMAGNE----SEEALTALMSRKTAIS 252
Cdd:pfam00022 248 ----GDETTSSSIPTR-------VYE---------LPD-------------GSTIILGAErfrvPEILFNPSLIGSESEL 294

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237 253 LFEGKALGLDKAILHSVDCCSSDdTKKKMYSSILVVGGGLMFHKAQEFLQHRILNKMPPSFRriienVDVITRPKDMDPR 332
Cdd:pfam00022 295 PPPQTAVGIPELIVDAINACDVD-LRPSLLANIVVTGGNSLFPGFTERLEKELAQLAPPGVK-----VKIIAPGNTVERR 368

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1720380237 333 LIAWKGGAVLACLDTTQELWIYQREWQRFGVR 364
Cdd:pfam00022 369 YSAWIGGSILASLGTFQQMWVSKQEYEEHGAS 400
ASKHA_NBD_actin_Arp-T1-3 cd13397
nucleotide-binding domain (NBD) of actin, actin-related proteins T1-T3 (Arp-T1-3), and similar ...
 252-362 8.83e-12

nucleotide-binding domain (NBD) of actin, actin-related proteins T1-T3 (Arp-T1-3), and similar proteins; The family includes actin and human actin-related proteins T1, T2, and T3. Actin is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. It is a highly dynamic structural protein network involved in processes such as cell contraction, cell motility, vesicle trafficking, intracellular organization, cytokinesis, endocytosis and apoptosis. Arp-T1, encoded by ACTRT1/ARPT1 gene expressed in testis, negatively regulates the Hedgehog (SHH) signaling, binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression. Arp-T2 (also called actin-related protein M2; encoded by ACTRT2/ARPM2 gene expressed in testis and various other cell types) and Arp-T3 (also called actin-related protein M1; encoded by ACTRT3/ARPM1 gene expressed in all tested human tissues) play general roles in the organization of the cytoskeleton like other cytoplasmic actin-related proteins.


Pssm-ID: 466848 [Multi-domain]  Cd Length: 359  Bit Score: 65.67  E-value: 8.83e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237 252 SLFEGKALGLDKAILHSVDCCSSDdTKKKMYSSILVVGGGLMFHKAQEFLQHRILNKMPPSfrriiENVDVITRPkdmDP 331
Cdd:cd13397   258 SLIGREAPGIHKLVYNSIMKCDID-IRKDLYSNIVLSGGSTMFPGLPERLQKELEALAPSS-----TKVKVIAPP---ER 328

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1720380237 332 RLIAWKGGAVLACLDTTQELWIYQREWQRFG 362
Cdd:cd13397   329 KYSVWIGGSILASLSTFKSMWITRAEYDEFG 359
ASKHA_NBD_Arp4_ACTL6-like cd13395
nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The ...
 255-358 8.58e-10

nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The Arp4-like subfamily includes Arp4, also called actin-like protein 4, from fungi and plants. Saccharomyces cerevisiae Arp4 acts synergistically with Arp8 to depolymerize F-actin; it binds ATP, but unlike conventional actin, does not form filaments. It is a component of the NuA4 histone acetyltransferase complex, the chromatin-remodeling INO80 complex and the SWR1 chromatin remodeling complex. Arabidopsis thaliana Arp4 is involved in several developmental processes including organization of plant organs, flowering time, anther development, flower senescence and fertility, probably by regulating the chromatin structure. This family also includes human homologs of yeast and plant, which are actin-like protein 6A (encoded by the ACTL6A gene; also known as ArpNbeta, 53 kDa BRG1-associated factor A/BRG1-associated factor 53A/BAF35A, and INO80 complex subunit K/INO80K) and actin-like protein 6B (encoded by the ACTL6B gene; also known as ArpNalpha, 53 kDa BRG1-associated factor B/BRG1-associated factor 53B/BAF35B). ACTL6A and ACTL6B are involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). They are components of numerous complexes with chromatin remodeling and histone acetyltransferase activity. ACTL6A is also a putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Schizosaccharomyces pombe actin-related protein 42 (Arp42) is also included in this family. It is also a component of SWI/SNF and RSC complexes.


Pssm-ID: 466846 [Multi-domain]  Cd Length: 413  Bit Score: 59.89  E-value: 8.58e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237 255 EGKALGLDKAILHSVDCCSSDdTKKKMYSSILVVGGGLMFHKAQEFLQHRILNKMPPSFRriienVDVITRPKDMDPRLI 334
Cdd:cd13395   312 GNELLGLPQLVYTSIGSCDVD-IRPELYGNVVLTGGNSLLPGFTDRLNRELSEKAPGSLK-----LKILASGNTVERRFS 385

                          90       100
                  ....*....|....*....|....
gi 1720380237 335 AWKGGAVLACLDTTQELWIYQREW 358
Cdd:cd13395   386 SWIGGSILASLGSFQQMWISKQEY 409
ASKHA_NBD_ACTL7 cd10214
nucleotide-binding domain (NBD) of the actin-like protein 7 (ACTL7)-like family; The ...
 252-362 2.34e-09

nucleotide-binding domain (NBD) of the actin-like protein 7 (ACTL7)-like family; The ACTL7-like family includes ACTL7A, ACTL7B and ACTL9 (also known as ACTL7C). In mammalian, ACTL7A is expressed in a wide variety of adult tissues, while the ACTL7B is expressed in spermatids through the elongation phase of spermatid development. ACTL7A, also called actin-like-7-alpha, or T-ACTIN-2 in mouse, may play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis. ACTL7B, also called actin-like-7-beta, acts as a key regulator of spermiogenesis that is required for male fertility. ACTL9 is a testis-specific protein that plays an important role in fusion of proacrosomal vesicles and perinuclear theca formation.


Pssm-ID: 466819 [Multi-domain]  Cd Length: 368  Bit Score: 58.20  E-value: 2.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237 252 SLFEGKALGLDKAILHSVDCCSSDdTKKKMYSSILVVGGGLMFHKAQEFLQhRILNKMPPSfrriiENVDVITRPkdmDP 331
Cdd:cd10214   260 SLIGSKQPGLHTLTMNSLNKCDAN-LKKDLAKNILLCGGSTMFDGFPDRFQ-KELSKLCPN-----DNPIVAASP---ER 329

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1720380237 332 RLIAWKGGAVLACLDTTQELWIYQREWQRFG 362
Cdd:cd10214   330 KYSVWTGGSILASLKSFQQLWVRRREYEERG 360
PTZ00466 PTZ00466
actin-like protein; Provisional
 259-370 1.01e-07

actin-like protein; Provisional


Pssm-ID: 240426 [Multi-domain]  Cd Length: 380  Bit Score: 53.41  E-value: 1.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237 259 LGLDKAILHSVDCCSSDdTKKKMYSSILVVGGGLMFHKAQEflqhRILNKMppsfRRIIenvdvitrPKDMDPRLIA--- 335
Cdd:PTZ00466  277 LGLSELIVTSITRADMD-LRRTLYSHIVLSGGTTMFHGFGD----RLLNEI----RKFA--------PKDITIRISAppe 339

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1720380237 336 -----WKGGAVLACLDTTQELWIYQREWQRFGVRMLRERA 370
Cdd:PTZ00466  340 rkfstFIGGSILASLATFKKIWISKQEFDEYGSVILHRKT 379
ASKHA_NBD_Arp1 cd10216
nucleotide-binding domain (NBD) of actin-related protein 1 (Arp1) and similar proteins; Arp1, ...
 274-370 2.03e-07

nucleotide-binding domain (NBD) of actin-related protein 1 (Arp1) and similar proteins; Arp1, also called centractin, actin-like protein, alpha-centractin, actin-RPV, or centrosome-associated actin homolog, may be a component of a multi-subunit centrosomal complex involved in microtubule-based vesicle motility. In yeast, actin-related protein is essential for viability and is associated with the centrosome. In vertebrates, Arp1 is a core component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding. The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint. ARP1 forms the backbone filament of the dynactin rod structure and serves as the scaffold for the remaining subunits. It is required for proper orientation of the mitotic spindle. Arp1 is the only actin-related protein known to form actin-like filaments. Human Arp1/centractin is encoded by the ACTR1A gene.


Pssm-ID: 466820 [Multi-domain]  Cd Length: 370  Bit Score: 52.16  E-value: 2.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237 274 SD-DTKKKMYSSILVVGGGLMFhkaQEFLQhRILNKMppsfRRIIenvdvitrPKDMDPRLIA--------WKGGAVLAC 344
Cdd:cd10216   281 SDlDLRKTLYSNIVLSGGSTLF---KGFGD-RLLSEV----KKLA--------PKDVKIRISApperlystWIGGSILAS 344

                          90       100
                  ....*....|....*....|....*.
gi 1720380237 345 LDTTQELWIYQREWQRFGVRMLRERA 370
Cdd:cd10216   345 LSTFKKMWVSKKEYEEDGARILHRKT 370
ASKHA_NBD_Arp2 cd10220
nucleotide-binding domain (NBD) of actin-related protein2 (Arp2) and similar proteins; Arp2, ...
 5-152 2.38e-07

nucleotide-binding domain (NBD) of actin-related protein2 (Arp2) and similar proteins; Arp2, also called actin-like protein 2, is the ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex is comprised of 7 proteins (Arp2, Arp3, and five conserved proteins, ARPC1-5). It generates cytoplasmic branched filaments networks, by promoting nucleation of actin filaments as 70 degrees branches on the side of older filaments. It is activated, by simultaneously binding to a pre-existing filament and a nucleation promoting factor plus an actin monomer. Daughter branches subsequently detach/debranch from the mother filament. Its Arp2 and Arp3 subunits must be loaded with ATP for it to initiate the assembly of branched actin filaments. ATP hydrolysis may be required for branch initiation or debranching. The Arp2/3 complex is also found in the nucleus where it plays a role in promoting de novo actin polymerization and in RNA polymerase II-dependent transcription. This may in part be through regulating nuclear actin polymerization in a way like its function in the cytoplasm. Human Arp2 is encoded by the ACTR2 gene.


Pssm-ID: 466821  Cd Length: 381  Bit Score: 52.18  E-value: 2.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237   5 KMGFAGIVVHQESVCATFGSGLSSTCVVDVGDQKTSVCCVEDGVS--HRNTRLCLAygGSDVSRCFYWLMQRAGFPYrec 82
Cdd:cd10220   123 KYGFAGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHIVPVYEGFSlpHLTRRLDVA--GRDITRYLIKLLLLRGYAF--- 197

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720380237  83 qltNK-MDCLLLQHLKETFCHLDQDIsglqDHEFQIRHpDSPALLYQF--------RLGDEKLQAPMALFYPATFGIVG 152
Cdd:cd10220   198 ---NRtADFETVREIKEKLCYVAYDI----ELEQKLAL-ETTVLVESYtlpdgrviKVGGERFEAPEALFQPHLIDVEG 268
PTZ00281 PTZ00281
actin; Provisional
 174-369 2.70e-07

actin; Provisional


Pssm-ID: 173506 [Multi-domain]  Cd Length: 376  Bit Score: 52.01  E-value: 2.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237 174 YLLATQSKQEQSAKATADR--------KSASKPIGFEGDLRGQSSDlperlHSQEVDLASSQGDCLMAGNESEEALTALm 245
Cdd:PTZ00281  189 YMMKILTERGYSFTTTAEReivrdikeKLAYVALDFEAEMQTAASS-----SALEKSYELPDGQVITIGNERFRCPEAL- 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237 246 srktaislFEGKALGLDKAILH-----SVDCCSSDdTKKKMYSSILVVGGGLMFHKAQEFLQHRILNKMPPSFRriienV 320
Cdd:PTZ00281  263 --------FQPSFLGMESAGIHettynSIMKCDVD-IRKDLYGNVVLSGGTTMFPGIADRMNKELTALAPSTMK-----I 328

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1720380237 321 DVITRPkdmDPRLIAWKGGAVLACLDTTQELWIYQREWQRFGVRMLRER 369
Cdd:PTZ00281  329 KIIAPP---ERKYSVWIGGSILASLSTFQQMWISKEEYDESGPSIVHRK 374
ASKHA_NBD_actin cd10224
nucleotide-binding domain (NBD) of actin and similar proteins; Actin is a ubiquitous protein ...
 253-362 7.06e-07

nucleotide-binding domain (NBD) of actin and similar proteins; Actin is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. It is a highly dynamic structural protein network involved in processes such as cell contraction, cell motility, vesicle trafficking, intracellular organization, cytokinesis, endocytosis and apoptosis. Actin is a monomeric globular protein (G-actin) that reversibly polymerizes to form filaments (F-actin). Each actin protomer binds one molecule of ATP and either calcium or magnesium ions. At low salt concentrations, actin exists as a monomer, and as the salt concentration rises F-actin forms, with the consequent hydrolysis of ATP. F-actin assembly is in constant flux with G-actin association occurring at the barbed end (+) and its disassociation at the pointed end (-). Actin monomers that have been released from the pointed end can be reused, if the ADP is exchanged for ATP. F-actin filaments can assemble into higher order structures, for example branched F-actin, and stress fibers. Actin binding proteins regulate actin filament dynamics by a range of functions including actin severing, depolymerizing, capping, stabilizing and de novo actin polymerization. Actins interaction with myosin is the basis of muscular contraction and many aspects of cell motility. In vertebrates there are three main groups of actin isoforms, alpha, beta and gamma. The alpha actins found in muscle tissues are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. In plants there are many isoforms which are probably involved in a variety of functions such as cytoplasmic streaming, cell shape determination, tip growth, graviperception, cell wall deposition, etc.


Pssm-ID: 466823  Cd Length: 365  Bit Score: 50.44  E-value: 7.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237 253 LFEGKALGLDKAILH-----SVDCCSSDdTKKKMYSSILVVGGGLMFHKAQEFLQHRILNKMPPSFRriienVDVITRPk 327
Cdd:cd10224   256 LFQPSFLGMEAAGIHettynSIMKCDVD-IRKDLYANIVLSGGTTMFPGIADRMQKEITALAPSTMK-----IKIVAPP- 328

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1720380237 328 dmDPRLIAWKGGAVLACLDTTQELWIYQREWQRFG 362
Cdd:cd10224   329 --ERKYSVWIGGSILASLSTFQQMWISKQEYDESG 361
PTZ00004 PTZ00004
actin-2; Provisional
 258-362 7.46e-07

actin-2; Provisional


Pssm-ID: 240225 [Multi-domain]  Cd Length: 378  Bit Score: 50.54  E-value: 7.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237 258 ALGLDKAILHSVDCCSSDdTKKKMYSSILVVGGGLMFHKAQEFLQHRILNKMPPSFRriienVDVITRPKDMDPrliAWK 337
Cdd:PTZ00004  274 PPGIHELTFQSINKCDID-IRKDLYGNIVLSGGTTMYRGLPERLTKELTTLAPSTMK-----IKVVAPPERKYS---VWI 344

                          90       100
                  ....*....|....*....|....*
gi 1720380237 338 GGAVLACLDTTQELWIYQREWQRFG 362
Cdd:PTZ00004  345 GGSILSSLPTFQQMWVTKEEYDESG 369
ASKHA_NBD_AtARP7-like cd10209
nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 7 and similar ...
 9-150 9.36e-06

nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 7 and similar proteins; Arabidopsis thaliana ARP7 is an essential nuclear protein, ubiquitously expressed in all cell types. It is needed for normal embryogenesis, plant architecture, and floral organ abscission. It may play a role in regulating various phases of plant development through chromatin-mediated gene regulation.


Pssm-ID: 466815 [Multi-domain]  Cd Length: 354  Bit Score: 47.00  E-value: 9.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237   9 AGIVVHQESVCATFGSGLSSTCVVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAGfPYRecqltnKM 88
Cdd:cd10209   111 SGLYASEQAVLSLYAVGRISGCVVDVGHGKIDIAPVWEGAIQHNAVRRFEIGGRDLTELLAAELGKSN-PKV------KL 183

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720380237  89 DCLLLQHLKETFCHLDQD-------ISGLQDHEFQIrhPDSPallyQFRLGDEKLQAPMALFYPATFGI 150
Cdd:cd10209   184 DRSIVERLKEAVAWSADDeeayekkVLTCSPETYTL--PDGR----VISVGKERYCVGEALFRPSILGI 246
PTZ00452 PTZ00452
actin; Provisional
 253-369 1.43e-05

actin; Provisional


Pssm-ID: 185631  Cd Length: 375  Bit Score: 46.67  E-value: 1.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237 253 LFEGKALGLDKAILH-----SVDCCSSDdTKKKMYSSILVVGGGLMFHKAQEFLQHRILNKMPPSFRriienVDVITRPk 327
Cdd:PTZ00452  261 LFQPKLIGLEVAGIHhlaysSIKKCDLD-LRQELCRNIVLSGGTTLFPGIANRLSNELTNLVPSQLK-----IQVAAPP- 333

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1720380237 328 dmDPRLIAWKGGAVLACLDTTQELWIYQREWQRFGVRMLRER 369
Cdd:PTZ00452  334 --DRRFSAWIGGSIQCTLSTQQPQWIKRQEYDEQGPSIVHRK 373
ASKHA_NBD_Arp6 cd10210
nucleotide-binding domain (NBD) of actin-related protein6 (Arp6) and similar proteins; Arp6, ...
 260-362 2.21e-05

nucleotide-binding domain (NBD) of actin-related protein6 (Arp6) and similar proteins; Arp6, also called actin-like protein 6, is required for formation and/or maintenance of proper nucleolar structure and function, plays a dual role in the regulation of ribosomal DNA (rDNA) transcription. In the presence of high glucose, Arp6 maintains active rDNA transcription through H2A.Z deposition and under glucose starvation, it is required for the repression of rDNA transcription, and this function may be independent of H2A.Z. Arp6 is also required for telomere silencing in both fission and budding yeast. It is a component of the budding yeast and Arabidopsis SWR1 complex (SWR1C) and the human SWI2/SNF2-related CBP activator protein (SRCAP) chromatin remodeling complexes which catalyze the exchange of the histone H2A with the H2AZ. Drosophila Arp6 colocalizes with HP1 (heterochromatin protein 1) in the pericentric heterochromatin, and vertebrate Arp6 also interacts with HP1. Human Arp6 is encoded by the ACTR6 gene. Arabidopsis thaliana ACTIN RELATED PROTEIN 6/EARLY IN SHORT DAYS 1/SUPPRESSOR OF FRIGIDA 3 (encoded by ARP6/ESD1/SUF3) participates in regulating several leaf and flower development stages. It is needed for Flowering locus C (FLC, the master repressor of flowering) and FLC-like gene expression in the shoot and root apex, and for the activity of the floral repressor pathway.


Pssm-ID: 466816 [Multi-domain]  Cd Length: 389  Bit Score: 46.00  E-value: 2.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237 260 GLDKAILHSVDCCSSDdTKKKMYSSILVVGGGLMFhkaqeflqhrilnkmpPSFRRIIEN---------VDV-ITRPkdM 329
Cdd:cd10210   296 GIAEAIVQSINACPEE-LQPLLYANIVLTGGNALF----------------PGFRERLEAelrslapddYDVnVTLP--E 356

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1720380237 330 DPRLIAWKGGAVLACLDTTQELWIYQREWQRFG 362
Cdd:cd10210   357 DPITYAWEGGSLLAQSPEFEELAVTRAEYEEHG 389
ASKHA_NBD_ScArp9-like cd10208
nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein 9 (Arp9) and ...
 9-66 2.13e-04

nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein 9 (Arp9) and similar proteins; Saccharomyces cerevisiae Arp9, also called actin-like protein 9, chromatin structure-remodeling complex protein ARP9, or SWI/SNF complex component ARP9, is a component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. It is also part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of many genes. Arp9 forms a stable heterodimer with Arp7 protein in both the RSC and SWI/SNF chromatin-remodeling complexes. It has been suggested that this dimer functions as a module with DNA bending proteins, to achieve correct architecture and facilitate complex-complex interactions. Fission yeast SWI/SNF and RSC complexes do not contain Arp7 and Arp8, but instead contain Arp9 and Arp42.


Pssm-ID: 466814  Cd Length: 356  Bit Score: 42.68  E-value: 2.13e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720380237   9 AGIVVHQESVCATFGSGLSSTCVVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSR 66
Cdd:cd10208   100 PAFAILEAPLAALYAAGATSGIVVDIGHEKTDITPIVDSQVVPHALVSIPIGGQDCTA 157
ASKHA_NBD_Arp5 cd10211
nucleotide-binding domain (NBD) of actin-related protein5 (Arp5) and similar proteins; Arp5, ...
 260-368 3.78e-04

nucleotide-binding domain (NBD) of actin-related protein5 (Arp5) and similar proteins; Arp5, also called actin-like protein 5, may act as a core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. It is involved in DNA double-strand break repair and UV-damage excision repair. Human Arp5 is encoded by the ACTR5 gene. Arabidopsis thaliana ARP5 (AtARp5) is a ubiquitously expressed nuclear protein involved in DNA repair and required for multicellular development of all organs. AtARp5 may be part of other chromatin remodeling machines in addition to INO80.


Pssm-ID: 466817 [Multi-domain]  Cd Length: 345  Bit Score: 42.17  E-value: 3.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380237 260 GLDKAILHSVdCCSSDDTKKKMYSSILVVGGGLMFhkaqEFLQHRILNkmppSFRRIIENVDVITRPKDMDPRLIAWKGG 339
Cdd:cd10211   245 GLVETIEFVL-KRYPAEQQDRLVQNVFLTGGNALF----PGLKERLEK----ELRAIRPFGSPFNVVRAKDPVLDAWRGA 315

                          90       100
                  ....*....|....*....|....*....
gi 1720380237 340 AVLACLDTTQELWIYQREWQRFGVRMLRE 368
Cdd:cd10211   316 AKWALDSTFEKVWITKQEYEEKGGEYLKE 344
Actin_micro pfam17003
Putative actin-like family; This is a family of microsporidial-specific proteins of unknown ...
 335-372 1.01e-03

Putative actin-like family; This is a family of microsporidial-specific proteins of unknown function. There is distant homology to the Actin family.


Pssm-ID: 374929  Cd Length: 350  Bit Score: 40.90  E-value: 1.01e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1720380237 335 AWKGGAVLACLDTTQELWIYQREWQRFGVRMLRERAAF 372
Cdd:pfam17003 311 ILRGAKVFNNLELSKELWLTDKEWNSVRLRVLKEKVLF 348
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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