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Conserved domains on  [gi|1720375720|ref|XP_030103256|]
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ras-responsive element-binding protein 1 isoform X4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1506-1530 6.86e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.90  E-value: 6.86e-06
                           10        20
                   ....*....|....*....|....*
gi 1720375720 1506 DLTRHMRSHTGERPYKCQTCERTFT 1530
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1183-1208 8.10e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.90  E-value: 8.10e-06
                           10        20
                   ....*....|....*....|....*.
gi 1720375720 1183 SLQRHMLTHTGQKPFPCQKCDAFFST 1208
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
29-54 1.83e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 1.83e-05
                           10        20
                   ....*....|....*....|....*.
gi 1720375720   29 SLDRHMLVHSGERPYKCTVCGQSFTT 54
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
587-611 4.74e-05

C2H2-type zinc-finger domain;


:

Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 41.77  E-value: 4.74e-05
                           10        20
                   ....*....|....*....|....*
gi 1720375720  587 YQCNICDYIAADKAALIRHIRTHSG 611
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-C2H2_6 pfam13912
C2H2-type zinc finger;
1493-1514 2.03e-03

C2H2-type zinc finger;


:

Pssm-ID: 433576  Cd Length: 27  Bit Score: 37.22  E-value: 2.03e-03
                           10        20
                   ....*....|....*....|..
gi 1720375720 1493 VCSVCNKRFWSLQDLTRHMRSH 1514
Cdd:pfam13912    3 ECSECGKSFPSYQALGGHKKSH 24
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 124-146 2.13e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


:

Pssm-ID: 464025  Cd Length: 24  Bit Score: 37.24  E-value: 2.13e-03
                           10        20
                   ....*....|....*....|...
gi 1720375720  124 FHCPVCFKEFVCKYELETHMETH 146
Cdd:pfam13894    1 FKCPICGKSFSSKKSLKRHLKTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1520-1542 2.58e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 2.58e-03
                           10        20
                   ....*....|....*....|...
gi 1720375720 1520 YKCQTCERTFTLKHSLVRHQRIH 1542
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 15-37 7.51e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 7.51e-03
                           10        20
                   ....*....|....*....|...
gi 1720375720   15 HACSICGKSLSSASSLDRHMLVH 37
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
ZnF_C2H2 smart00355
zinc finger;
1171-1191 9.81e-03

zinc finger;


:

Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.13  E-value: 9.81e-03
                            10        20
                    ....*....|....*....|.
gi 1720375720  1171 CPHCPRVFPWASSLQRHMLTH 1191
Cdd:smart00355    3 CPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1506-1530 6.86e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.90  E-value: 6.86e-06
                           10        20
                   ....*....|....*....|....*
gi 1720375720 1506 DLTRHMRSHTGERPYKCQTCERTFT 1530
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1183-1208 8.10e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.90  E-value: 8.10e-06
                           10        20
                   ....*....|....*....|....*.
gi 1720375720 1183 SLQRHMLTHTGQKPFPCQKCDAFFST 1208
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
29-54 1.83e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 1.83e-05
                           10        20
                   ....*....|....*....|....*.
gi 1720375720   29 SLDRHMLVHSGERPYKCTVCGQSFTT 54
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
587-611 4.74e-05

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 41.77  E-value: 4.74e-05
                           10        20
                   ....*....|....*....|....*
gi 1720375720  587 YQCNICDYIAADKAALIRHIRTHSG 611
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-C2H2_6 pfam13912
C2H2-type zinc finger;
1493-1514 2.03e-03

C2H2-type zinc finger;


Pssm-ID: 433576  Cd Length: 27  Bit Score: 37.22  E-value: 2.03e-03
                           10        20
                   ....*....|....*....|..
gi 1720375720 1493 VCSVCNKRFWSLQDLTRHMRSH 1514
Cdd:pfam13912    3 ECSECGKSFPSYQALGGHKKSH 24
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 124-146 2.13e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 37.24  E-value: 2.13e-03
                           10        20
                   ....*....|....*....|...
gi 1720375720  124 FHCPVCFKEFVCKYELETHMETH 146
Cdd:pfam13894    1 FKCPICGKSFSSKKSLKRHLKTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1520-1542 2.58e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 2.58e-03
                           10        20
                   ....*....|....*....|...
gi 1720375720 1520 YKCQTCERTFTLKHSLVRHQRIH 1542
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
ZnF_C2H2 smart00355
zinc finger;
43-65 3.61e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 36.29  E-value: 3.61e-03
                            10        20
                    ....*....|....*....|...
gi 1720375720    43 YKCTVCGQSFTTNGNMHRHMKIH 65
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 15-37 7.51e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 7.51e-03
                           10        20
                   ....*....|....*....|...
gi 1720375720   15 HACSICGKSLSSASSLDRHMLVH 37
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
ZnF_C2H2 smart00355
zinc finger;
1171-1191 9.81e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.13  E-value: 9.81e-03
                            10        20
                    ....*....|....*....|.
gi 1720375720  1171 CPHCPRVFPWASSLQRHMLTH 1191
Cdd:smart00355    3 CPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1506-1530 6.86e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.90  E-value: 6.86e-06
                           10        20
                   ....*....|....*....|....*
gi 1720375720 1506 DLTRHMRSHTGERPYKCQTCERTFT 1530
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1183-1208 8.10e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.90  E-value: 8.10e-06
                           10        20
                   ....*....|....*....|....*.
gi 1720375720 1183 SLQRHMLTHTGQKPFPCQKCDAFFST 1208
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
29-54 1.83e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 1.83e-05
                           10        20
                   ....*....|....*....|....*.
gi 1720375720   29 SLDRHMLVHSGERPYKCTVCGQSFTT 54
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
587-611 4.74e-05

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 41.77  E-value: 4.74e-05
                           10        20
                   ....*....|....*....|....*
gi 1720375720  587 YQCNICDYIAADKAALIRHIRTHSG 611
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 43-65 1.37e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 40.36  E-value: 1.37e-04
                           10        20
                   ....*....|....*....|...
gi 1720375720   43 YKCTVCGQSFTTNGNMHRHMKIH 65
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2_6 pfam13912
C2H2-type zinc finger;
1493-1514 2.03e-03

C2H2-type zinc finger;


Pssm-ID: 433576  Cd Length: 27  Bit Score: 37.22  E-value: 2.03e-03
                           10        20
                   ....*....|....*....|..
gi 1720375720 1493 VCSVCNKRFWSLQDLTRHMRSH 1514
Cdd:pfam13912    3 ECSECGKSFPSYQALGGHKKSH 24
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 124-146 2.13e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 37.24  E-value: 2.13e-03
                           10        20
                   ....*....|....*....|...
gi 1720375720  124 FHCPVCFKEFVCKYELETHMETH 146
Cdd:pfam13894    1 FKCPICGKSFSSKKSLKRHLKTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1520-1542 2.58e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 2.58e-03
                           10        20
                   ....*....|....*....|...
gi 1720375720 1520 YKCQTCERTFTLKHSLVRHQRIH 1542
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
ZnF_C2H2 smart00355
zinc finger;
43-65 3.61e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 36.29  E-value: 3.61e-03
                            10        20
                    ....*....|....*....|...
gi 1720375720    43 YKCTVCGQSFTTNGNMHRHMKIH 65
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 43-65 5.37e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 36.08  E-value: 5.37e-03
                           10        20
                   ....*....|....*....|...
gi 1720375720   43 YKCTVCGQSFTTNGNMHRHMKIH 65
Cdd:pfam13894    1 FKCPICGKSFSSKKSLKRHLKTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
601-622 6.99e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 6.99e-03
                           10        20
                   ....*....|....*....|..
gi 1720375720  601 ALIRHIRTHSGERPYICKICHY 622
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGK 22
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 15-37 7.51e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 7.51e-03
                           10        20
                   ....*....|....*....|...
gi 1720375720   15 HACSICGKSLSSASSLDRHMLVH 37
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
ZnF_C2H2 smart00355
zinc finger;
1171-1191 9.81e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.13  E-value: 9.81e-03
                            10        20
                    ....*....|....*....|.
gi 1720375720  1171 CPHCPRVFPWASSLQRHMLTH 1191
Cdd:smart00355    3 CPECGKVFKSKSALREHMRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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