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Conserved domains on  [gi|1720375298|ref|XP_030103138|]
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centromere protein H isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
46 super family cl33686
endonuclease subunit; Provisional
 26-113 2.81e-04

endonuclease subunit; Provisional


The actual alignment was detected with superfamily member PHA02562:

Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 40.00  E-value: 2.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375298  26 AEERIEDRISLLLRLRAQTKQQLLEYKSMIDTNEEKTPEQIMQEKQIEVKIEELENEIEDVKSNIEMKSLALSRMKLSVA 105
Cdd:PHA02562  193 IQQQIKTYNKNIEEQRKKNGENIARKQNKYDELVEEAKTIKAEIEELTDELLNLVMDIEDPSAALNKLNTAAAKIKSKIE 272


                  ....*...
gi 1720375298 106 LRDNMENM 113
Cdd:PHA02562  273 QFQKVIKM 280
CENP-H super family cl09387
Centromere protein H (CENP-H); This family consists of several eukaryotic centromere protein H ...
 136-157 7.52e-03

Centromere protein H (CENP-H); This family consists of several eukaryotic centromere protein H (CENP-H) sequences. Macromolecular centromere-kinetochore complex plays a critical role in sister chromatid separation, but its complete protein composition as well as its precise dynamic function during mitosis has not yet been clearly determined. CENP-H contains a coiled-coil structure and a nuclear localization signal. CENP-H is specifically and constitutively localized in kinetochores throughout the cell cycle. CENP-H may play a role in kinetochore organization and function throughout the cell cycle. This the C-terminus of the region, which is conserved from fungi to humans.


The actual alignment was detected with superfamily member pfam05837:

Pssm-ID: 461756 [Multi-domain]  Cd Length: 114  Bit Score: 34.48  E-value: 7.52e-03
                          10        20
                  ....*....|....*....|..
gi 1720375298 136 GLILASKTNWAEDPALRETVLQ 157
Cdd:pfam05837  93 AIIVGSGVDWAEDEKLRELVLD 114
 
Name Accession Description Interval E-value
46 PHA02562
endonuclease subunit; Provisional
 26-113 2.81e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 40.00  E-value: 2.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375298  26 AEERIEDRISLLLRLRAQTKQQLLEYKSMIDTNEEKTPEQIMQEKQIEVKIEELENEIEDVKSNIEMKSLALSRMKLSVA 105
Cdd:PHA02562  193 IQQQIKTYNKNIEEQRKKNGENIARKQNKYDELVEEAKTIKAEIEELTDELLNLVMDIEDPSAALNKLNTAAAKIKSKIE 272


                  ....*...
gi 1720375298 106 LRDNMENM 113
Cdd:PHA02562  273 QFQKVIKM 280
CENP-H pfam05837
Centromere protein H (CENP-H); This family consists of several eukaryotic centromere protein H ...
 136-157 7.52e-03

Centromere protein H (CENP-H); This family consists of several eukaryotic centromere protein H (CENP-H) sequences. Macromolecular centromere-kinetochore complex plays a critical role in sister chromatid separation, but its complete protein composition as well as its precise dynamic function during mitosis has not yet been clearly determined. CENP-H contains a coiled-coil structure and a nuclear localization signal. CENP-H is specifically and constitutively localized in kinetochores throughout the cell cycle. CENP-H may play a role in kinetochore organization and function throughout the cell cycle. This the C-terminus of the region, which is conserved from fungi to humans.


Pssm-ID: 461756 [Multi-domain]  Cd Length: 114  Bit Score: 34.48  E-value: 7.52e-03
                          10        20
                  ....*....|....*....|..
gi 1720375298 136 GLILASKTNWAEDPALRETVLQ 157
Cdd:pfam05837  93 AIIVGSGVDWAEDEKLRELVLD 114
 
Name Accession Description Interval E-value
46 PHA02562
endonuclease subunit; Provisional
 26-113 2.81e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 40.00  E-value: 2.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375298  26 AEERIEDRISLLLRLRAQTKQQLLEYKSMIDTNEEKTPEQIMQEKQIEVKIEELENEIEDVKSNIEMKSLALSRMKLSVA 105
Cdd:PHA02562  193 IQQQIKTYNKNIEEQRKKNGENIARKQNKYDELVEEAKTIKAEIEELTDELLNLVMDIEDPSAALNKLNTAAAKIKSKIE 272


                  ....*...
gi 1720375298 106 LRDNMENM 113
Cdd:PHA02562  273 QFQKVIKM 280
CENP-H pfam05837
Centromere protein H (CENP-H); This family consists of several eukaryotic centromere protein H ...
 136-157 7.52e-03

Centromere protein H (CENP-H); This family consists of several eukaryotic centromere protein H (CENP-H) sequences. Macromolecular centromere-kinetochore complex plays a critical role in sister chromatid separation, but its complete protein composition as well as its precise dynamic function during mitosis has not yet been clearly determined. CENP-H contains a coiled-coil structure and a nuclear localization signal. CENP-H is specifically and constitutively localized in kinetochores throughout the cell cycle. CENP-H may play a role in kinetochore organization and function throughout the cell cycle. This the C-terminus of the region, which is conserved from fungi to humans.


Pssm-ID: 461756 [Multi-domain]  Cd Length: 114  Bit Score: 34.48  E-value: 7.52e-03
                          10        20
                  ....*....|....*....|..
gi 1720375298 136 GLILASKTNWAEDPALRETVLQ 157
Cdd:pfam05837  93 AIIVGSGVDWAEDEKLRELVLD 114
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 55-112 7.91e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 36.06  E-value: 7.91e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720375298  55 IDTNEEKTPEQIMqeKQIEVKIEELENEIEDVKSniEMKSLALSRMKLSVALRDNMEN 112
Cdd:PRK05771  205 LELEEEGTPSELI--REIKEELEEIEKERESLLE--ELKELAKKYLEELLALYEYLEI 258
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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