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Conserved domains on  [gi|1720364011|ref|XP_030101377|]
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granulocyte colony-stimulating factor isoform X2 [Mus musculus]

Protein Classification

GCSF domain-containing protein( domain architecture ID 11244616)

GCSF domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GCSF pfam16647
Granulocyte colony-stimulating factor; GCSF is a family of higher eukaryotic granulocyte ...
 108-256 5.36e-94

Granulocyte colony-stimulating factor; GCSF is a family of higher eukaryotic granulocyte colony-stimulating factor proteins. Granulocyte colony-stimulating factors are cytokines that are involved in haematopoeisis. They control the production, differentiation and function of white blood cell granulocytes. GCSF binds to the extracellular Ig-like and CRH domain of its receptor GCSFR, thereby triggering the receptor to homodimerize. Homodimerization result in activation of Janus tyrosine kinase-signal transducers and other activators of transcription (JAK-STAT)-type signalling cascades.


:

Pssm-ID: 406939  Cd Length: 149  Bit Score: 273.03  E-value: 5.36e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720364011 108 VRKIQASGSVLLEQLCATYKLCHPEELVLLGHSLGIPKASLSGCSSQALQQTQCLSQLHSGLCLYQGLLQALSGISPALA 187
Cdd:pfam16647   1 VRKIQADGAVLQEQLCATYKLCHPEELVLLGHSLGIPKAPLSSCSSQALQLTGCLSQLHSGLFLYQGLLQALSGISPELA 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720364011 188 PTLDLLQLDVANFATTIWQQMENLGVAPTVQPTQSAMPAFTSAFQRRAGGVLAISYLQGFLETARLALH 256
Cdd:pfam16647  81 PTLDTLQLDVADFATTIWQQMENLGVAPAVQPTQGAMPAFTSAFQRRAGGVLVASYLQGFLETAYRALR 149
 
Name Accession Description Interval E-value
GCSF pfam16647
Granulocyte colony-stimulating factor; GCSF is a family of higher eukaryotic granulocyte ...
 108-256 5.36e-94

Granulocyte colony-stimulating factor; GCSF is a family of higher eukaryotic granulocyte colony-stimulating factor proteins. Granulocyte colony-stimulating factors are cytokines that are involved in haematopoeisis. They control the production, differentiation and function of white blood cell granulocytes. GCSF binds to the extracellular Ig-like and CRH domain of its receptor GCSFR, thereby triggering the receptor to homodimerize. Homodimerization result in activation of Janus tyrosine kinase-signal transducers and other activators of transcription (JAK-STAT)-type signalling cascades.


Pssm-ID: 406939  Cd Length: 149  Bit Score: 273.03  E-value: 5.36e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720364011 108 VRKIQASGSVLLEQLCATYKLCHPEELVLLGHSLGIPKASLSGCSSQALQQTQCLSQLHSGLCLYQGLLQALSGISPALA 187
Cdd:pfam16647   1 VRKIQADGAVLQEQLCATYKLCHPEELVLLGHSLGIPKAPLSSCSSQALQLTGCLSQLHSGLFLYQGLLQALSGISPELA 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720364011 188 PTLDLLQLDVANFATTIWQQMENLGVAPTVQPTQSAMPAFTSAFQRRAGGVLAISYLQGFLETARLALH 256
Cdd:pfam16647  81 PTLDTLQLDVADFATTIWQQMENLGVAPAVQPTQGAMPAFTSAFQRRAGGVLVASYLQGFLETAYRALR 149
IL6 smart00126
Interleukin-6 homologues; Family includes granulocyte colony-stimulating factor (G-CSF) and ...
 108-255 5.33e-45

Interleukin-6 homologues; Family includes granulocyte colony-stimulating factor (G-CSF) and myelomonocytic growth factor (MGF). IL-6 is also known as B-cell stimulatory factor 2.


Pssm-ID: 128431  Cd Length: 154  Bit Score: 148.31  E-value: 5.33e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720364011  108 VRKIQASGSVLLEQLCATYKLCHPEELVLLGHSLGIPKAS-LSGCSSQALQQTQCLSQLHSGLCLYQGLLQALSGISPAL 186
Cdd:smart00126   1 IRKILWDIAELRKELCNRFSLCENSEEALAENNLKLPKMNeKDGCFQSGFNQEICLVKITAGLLEYQVYLEYLQNEFPEN 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720364011  187 APTLDLLQLDVANFATTIWQQMENLG--VAPTVQPTQSAMPAFTSAFQ--RRAGGVLAISYLQGFLETARLAL 255
Cdd:smart00126  81 KENVDTLQLDTKTLIQIIQQEMKDLGkiTYPTPTANRGLLPKLQSQNQwvRNATGFLILSSLERFLQFALRAL 153
 
Name Accession Description Interval E-value
GCSF pfam16647
Granulocyte colony-stimulating factor; GCSF is a family of higher eukaryotic granulocyte ...
 108-256 5.36e-94

Granulocyte colony-stimulating factor; GCSF is a family of higher eukaryotic granulocyte colony-stimulating factor proteins. Granulocyte colony-stimulating factors are cytokines that are involved in haematopoeisis. They control the production, differentiation and function of white blood cell granulocytes. GCSF binds to the extracellular Ig-like and CRH domain of its receptor GCSFR, thereby triggering the receptor to homodimerize. Homodimerization result in activation of Janus tyrosine kinase-signal transducers and other activators of transcription (JAK-STAT)-type signalling cascades.


Pssm-ID: 406939  Cd Length: 149  Bit Score: 273.03  E-value: 5.36e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720364011 108 VRKIQASGSVLLEQLCATYKLCHPEELVLLGHSLGIPKASLSGCSSQALQQTQCLSQLHSGLCLYQGLLQALSGISPALA 187
Cdd:pfam16647   1 VRKIQADGAVLQEQLCATYKLCHPEELVLLGHSLGIPKAPLSSCSSQALQLTGCLSQLHSGLFLYQGLLQALSGISPELA 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720364011 188 PTLDLLQLDVANFATTIWQQMENLGVAPTVQPTQSAMPAFTSAFQRRAGGVLAISYLQGFLETARLALH 256
Cdd:pfam16647  81 PTLDTLQLDVADFATTIWQQMENLGVAPAVQPTQGAMPAFTSAFQRRAGGVLVASYLQGFLETAYRALR 149
IL6 smart00126
Interleukin-6 homologues; Family includes granulocyte colony-stimulating factor (G-CSF) and ...
 108-255 5.33e-45

Interleukin-6 homologues; Family includes granulocyte colony-stimulating factor (G-CSF) and myelomonocytic growth factor (MGF). IL-6 is also known as B-cell stimulatory factor 2.


Pssm-ID: 128431  Cd Length: 154  Bit Score: 148.31  E-value: 5.33e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720364011  108 VRKIQASGSVLLEQLCATYKLCHPEELVLLGHSLGIPKAS-LSGCSSQALQQTQCLSQLHSGLCLYQGLLQALSGISPAL 186
Cdd:smart00126   1 IRKILWDIAELRKELCNRFSLCENSEEALAENNLKLPKMNeKDGCFQSGFNQEICLVKITAGLLEYQVYLEYLQNEFPEN 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720364011  187 APTLDLLQLDVANFATTIWQQMENLG--VAPTVQPTQSAMPAFTSAFQ--RRAGGVLAISYLQGFLETARLAL 255
Cdd:smart00126  81 KENVDTLQLDTKTLIQIIQQEMKDLGkiTYPTPTANRGLLPKLQSQNQwvRNATGFLILSSLERFLQFALRAL 153
IL6 pfam00489
Interleukin-6/G-CSF/MGF family;
103-223 2.58e-03

Interleukin-6/G-CSF/MGF family;


Pssm-ID: 395393  Cd Length: 184  Bit Score: 37.91  E-value: 2.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720364011 103 KSLEQVRKIQASGSVLLEQLCATYKLCHPEELVLLGHSLGIPK-ASLSGCSSQALQQTQCLSQLHSGLCLYQGLLQALSG 181
Cdd:pfam00489  25 KTEELIKYILGEISALRKEMCNNNDKCENSKEALAENNLNLPKmAEKDGCFQSGFNQETCLMKITTGLLEFQIYLDYLQN 104

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1720364011 182 ISPALAPTLDLLQLDVANFATTIWQQMENLGVAPTVQPTQSA 223
Cdd:pfam00489 105 KFEGNKENAKVLQRSTKTLVQILKQKVKNPHEITTPDPTTNA 146
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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