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Conserved domains on  [gi|1720361188|ref|XP_030100910|]
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protein timeless homolog isoform X6 [Mus musculus]

Protein Classification

TIMELESS_C domain-containing protein( domain architecture ID 10523486)

TIMELESS_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIMELESS_C pfam05029
Timeless PAB domain; The timeless (tim) gene is essential for circadian function in Drosophila. ...
 646-732 9.86e-32

Timeless PAB domain; The timeless (tim) gene is essential for circadian function in Drosophila. Putative homologs of Drosophila tim have been identified in both mice and humans (mTim and hTIM, respectively). Mammalian TIM is not the true orthologue of Drosophila TIM, but is the likely orthologue of a fly gene, timeout (also called tim-2). mTim has been shown to be essential for embryonic development, but does not have substantiated circadian function. This entry corresponds to the PAB (PARP-1-binding domain).


:

Pssm-ID: 461529 [Multi-domain]  Cd Length: 87  Bit Score: 118.56  E-value: 9.86e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361188 646 LGESLRQEGLSAPLLWLQSSLIRAANDREEDGCSQAIPLVPLTEENEEAMENEQFQHLLRKLGIRPPSSGQETFWRIPAK 725
Cdd:pfam05029   1 LGEDLVQEGLSEPLEWLQESLSEAAEDREKDGSAESIPLVPLTEEQEEAMENQKFLKLLRKLGIHPPADEQEIFWRIPGF 80


                  ....*..
gi 1720361188 726 LSSTQLR 732
Cdd:pfam05029  81 WSPDQLR 87
 
Name Accession Description Interval E-value
TIMELESS_C pfam05029
Timeless PAB domain; The timeless (tim) gene is essential for circadian function in Drosophila. ...
 646-732 9.86e-32

Timeless PAB domain; The timeless (tim) gene is essential for circadian function in Drosophila. Putative homologs of Drosophila tim have been identified in both mice and humans (mTim and hTIM, respectively). Mammalian TIM is not the true orthologue of Drosophila TIM, but is the likely orthologue of a fly gene, timeout (also called tim-2). mTim has been shown to be essential for embryonic development, but does not have substantiated circadian function. This entry corresponds to the PAB (PARP-1-binding domain).


Pssm-ID: 461529 [Multi-domain]  Cd Length: 87  Bit Score: 118.56  E-value: 9.86e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361188 646 LGESLRQEGLSAPLLWLQSSLIRAANDREEDGCSQAIPLVPLTEENEEAMENEQFQHLLRKLGIRPPSSGQETFWRIPAK 725
Cdd:pfam05029   1 LGEDLVQEGLSEPLEWLQESLSEAAEDREKDGSAESIPLVPLTEEQEEAMENQKFLKLLRKLGIHPPADEQEIFWRIPGF 80


                  ....*..
gi 1720361188 726 LSSTQLR 732
Cdd:pfam05029  81 WSPDQLR 87
 
Name Accession Description Interval E-value
TIMELESS_C pfam05029
Timeless PAB domain; The timeless (tim) gene is essential for circadian function in Drosophila. ...
 646-732 9.86e-32

Timeless PAB domain; The timeless (tim) gene is essential for circadian function in Drosophila. Putative homologs of Drosophila tim have been identified in both mice and humans (mTim and hTIM, respectively). Mammalian TIM is not the true orthologue of Drosophila TIM, but is the likely orthologue of a fly gene, timeout (also called tim-2). mTim has been shown to be essential for embryonic development, but does not have substantiated circadian function. This entry corresponds to the PAB (PARP-1-binding domain).


Pssm-ID: 461529 [Multi-domain]  Cd Length: 87  Bit Score: 118.56  E-value: 9.86e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361188 646 LGESLRQEGLSAPLLWLQSSLIRAANDREEDGCSQAIPLVPLTEENEEAMENEQFQHLLRKLGIRPPSSGQETFWRIPAK 725
Cdd:pfam05029   1 LGEDLVQEGLSEPLEWLQESLSEAAEDREKDGSAESIPLVPLTEEQEEAMENQKFLKLLRKLGIHPPADEQEIFWRIPGF 80


                  ....*..
gi 1720361188 726 LSSTQLR 732
Cdd:pfam05029  81 WSPDQLR 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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