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Conserved domains on  [gi|1720361139|ref|XP_030100901|]
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rab-3A-interacting protein isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rab11BD_RAB3IP cd21068
Rab11 binding domain of Rab-3A-interacting protein (RAB3IP); RAB3IP, also called Rabin-3, or ...
 234-426 2.83e-144

Rab11 binding domain of Rab-3A-interacting protein (RAB3IP); RAB3IP, also called Rabin-3, or SSX2-interacting protein, or Rabin8, acts as a guanine nucleotide exchange factor (GEF) which promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. It mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. It modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. The model corresponds to the Rab11a/Rab11b-binding region of RAB3IP lies within its carboxy-terminus, a region distinct from its GEF domain and Rab3a-binding region.


:

Pssm-ID: 411032  Cd Length: 193  Bit Score: 408.92  E-value: 2.83e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361139 234 GHTRNKSTSSAMGGSHQDLSVIQPIVKDCKEADLSLYNEFRSWKDEPTMDRTCPFLDKIYQEDIFPCLTFAKSELASAVL 313
Cdd:cd21068     1 GHARNKSTSSAMSGSHQDLSVIQPIVKDCKEADLSLYNEFRLWKEEPTMDRTCPFLDRIYQEDIFPCLTFSKSELASAVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361139 314 EAVENNTLSIEPVGLQPIRFVKASAVECGGPKKCALTGQSKPCRHRIRLGDSSCCYYISPFCRYRITSVCNFFTYIRYIQ 393
Cdd:cd21068    81 EAVENNTLSIEPVGLQPLRFVKASAVECGGPKKCALSGQTKSCKHRIKLGDSSNYYYISPFCRYRITSVCNFFTYIRYIQ 160

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1720361139 394 QGLVKQQDVDQMFWEVMQLRKEMSLAKLGYFKE 426
Cdd:cd21068   161 QGLVKQQDVDQMFWEVMQLRKEMSLAKLGYYKE 193
ATG16 super family cl25514
Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for ...
 103-209 1.40e-04

Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway.


The actual alignment was detected with superfamily member pfam08614:

Pssm-ID: 462536 [Multi-domain]  Cd Length: 176  Bit Score: 42.23  E-value: 1.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361139 103 TKLTSRKDSCNAEREFLQGATITEASAGNDdifglSTDSLSRLRSPSVLEVREKGYeRLKEELAKAQR---EAHKMVREA 179
Cdd:pfam08614  10 NRLLDRTALLEAENAKLQSEPESVLPSTSS-----SKLSKASPQSASIQSLEQLLA-QLREELAELYRsrgELAQRLVDL 83

                          90       100       110
                  ....*....|....*....|....*....|
gi 1720361139 180 NVKQATAEKQLKEAQGKIDVLQAEVAALKT 209
Cdd:pfam08614  84 NEELQELEKKLREDERRLAALEAERAQLEE 113
 
Name Accession Description Interval E-value
Rab11BD_RAB3IP cd21068
Rab11 binding domain of Rab-3A-interacting protein (RAB3IP); RAB3IP, also called Rabin-3, or ...
 234-426 2.83e-144

Rab11 binding domain of Rab-3A-interacting protein (RAB3IP); RAB3IP, also called Rabin-3, or SSX2-interacting protein, or Rabin8, acts as a guanine nucleotide exchange factor (GEF) which promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. It mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. It modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. The model corresponds to the Rab11a/Rab11b-binding region of RAB3IP lies within its carboxy-terminus, a region distinct from its GEF domain and Rab3a-binding region.


Pssm-ID: 411032  Cd Length: 193  Bit Score: 408.92  E-value: 2.83e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361139 234 GHTRNKSTSSAMGGSHQDLSVIQPIVKDCKEADLSLYNEFRSWKDEPTMDRTCPFLDKIYQEDIFPCLTFAKSELASAVL 313
Cdd:cd21068     1 GHARNKSTSSAMSGSHQDLSVIQPIVKDCKEADLSLYNEFRLWKEEPTMDRTCPFLDRIYQEDIFPCLTFSKSELASAVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361139 314 EAVENNTLSIEPVGLQPIRFVKASAVECGGPKKCALTGQSKPCRHRIRLGDSSCCYYISPFCRYRITSVCNFFTYIRYIQ 393
Cdd:cd21068    81 EAVENNTLSIEPVGLQPLRFVKASAVECGGPKKCALSGQTKSCKHRIKLGDSSNYYYISPFCRYRITSVCNFFTYIRYIQ 160

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1720361139 394 QGLVKQQDVDQMFWEVMQLRKEMSLAKLGYFKE 426
Cdd:cd21068   161 QGLVKQQDVDQMFWEVMQLRKEMSLAKLGYYKE 193
ATG16 pfam08614
Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for ...
 103-209 1.40e-04

Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway.


Pssm-ID: 462536 [Multi-domain]  Cd Length: 176  Bit Score: 42.23  E-value: 1.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361139 103 TKLTSRKDSCNAEREFLQGATITEASAGNDdifglSTDSLSRLRSPSVLEVREKGYeRLKEELAKAQR---EAHKMVREA 179
Cdd:pfam08614  10 NRLLDRTALLEAENAKLQSEPESVLPSTSS-----SKLSKASPQSASIQSLEQLLA-QLREELAELYRsrgELAQRLVDL 83

                          90       100       110
                  ....*....|....*....|....*....|
gi 1720361139 180 NVKQATAEKQLKEAQGKIDVLQAEVAALKT 209
Cdd:pfam08614  84 NEELQELEKKLREDERRLAALEAERAQLEE 113
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 158-208 2.59e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 42.89  E-value: 2.59e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1720361139 158 YERLKEELAKAQREAHKMVREANVKQATAEKQLKEAQGKIDVLQAEVAALK 208
Cdd:COG3883   145 LEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAE 195
 
Name Accession Description Interval E-value
Rab11BD_RAB3IP cd21068
Rab11 binding domain of Rab-3A-interacting protein (RAB3IP); RAB3IP, also called Rabin-3, or ...
 234-426 2.83e-144

Rab11 binding domain of Rab-3A-interacting protein (RAB3IP); RAB3IP, also called Rabin-3, or SSX2-interacting protein, or Rabin8, acts as a guanine nucleotide exchange factor (GEF) which promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. It mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. It modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. The model corresponds to the Rab11a/Rab11b-binding region of RAB3IP lies within its carboxy-terminus, a region distinct from its GEF domain and Rab3a-binding region.


Pssm-ID: 411032  Cd Length: 193  Bit Score: 408.92  E-value: 2.83e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361139 234 GHTRNKSTSSAMGGSHQDLSVIQPIVKDCKEADLSLYNEFRSWKDEPTMDRTCPFLDKIYQEDIFPCLTFAKSELASAVL 313
Cdd:cd21068     1 GHARNKSTSSAMSGSHQDLSVIQPIVKDCKEADLSLYNEFRLWKEEPTMDRTCPFLDRIYQEDIFPCLTFSKSELASAVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361139 314 EAVENNTLSIEPVGLQPIRFVKASAVECGGPKKCALTGQSKPCRHRIRLGDSSCCYYISPFCRYRITSVCNFFTYIRYIQ 393
Cdd:cd21068    81 EAVENNTLSIEPVGLQPLRFVKASAVECGGPKKCALSGQTKSCKHRIKLGDSSNYYYISPFCRYRITSVCNFFTYIRYIQ 160

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1720361139 394 QGLVKQQDVDQMFWEVMQLRKEMSLAKLGYFKE 426
Cdd:cd21068   161 QGLVKQQDVDQMFWEVMQLRKEMSLAKLGYYKE 193
Rab11BD_RAB3IL1 cd21069
Rab11 binding domain of Rab-3A-interacting-like protein 1 (RAB3IL1); RAB3IL1, also called ...
 261-424 2.20e-92

Rab11 binding domain of Rab-3A-interacting-like protein 1 (RAB3IL1); RAB3IL1, also called guanine nucleotide exchange factor for Rab-3A (GRAB), or Rab3A-interacting-like protein 1, or Rabin3-like 1, acts as a guanine nucleotide exchange factor (GEF) which promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. As a dual Rab-binding protein, RAB3IL1 could potentially link Rab3 and Rab11 and/or Rab8 and Rab11-mediated intracellular trafficking processes. It may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. It may also activate RAB8A and RAB8B. In addition, RAB3IL1 interacts with InsP6K1 and plays a role for InsP7 in vesicle exocytosis. The model corresponds to the Rab11a/Rab11b-binding region of RAB3IL1 lies within its carboxy-terminus, a region distinct from its GEF domain and Rab3a-binding region.


Pssm-ID: 411033  Cd Length: 163  Bit Score: 275.59  E-value: 2.20e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361139 261 DCKEADLSLYNEFRSWKDEPTMDRTCPFLDKIYQEDIFPCLTFAKSELASAVLEAVENNTLSIEPVGLQPIRFVKASAVE 340
Cdd:cd21069     1 EGKEVDTVLFAEFQAWKESPTLDRSCPFLSRIYREDIGPCLDFTKRELSDLVQSAVENNTLTIEPVASQALPVVKASAVE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361139 341 CGGPKKCALTGQSKPCRHRIRLGDSSCCYYISPFCRYRITSVCNFFTYIRYIQQGLVKqQDVDQMFWEVMQLRKEMSLAK 420
Cdd:cd21069    81 CGGPKKCALSGLSRTCRHRIKLGDSGNYYYISPSCRARITAVCNFFTYIRYIQQGLVR-QDAEQMFWEVMRLRREMSLAK 159


                  ....
gi 1720361139 421 LGYF 424
Cdd:cd21069   160 LGFY 163
Rab11BD_RAB3IP_like cd21044
Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 ...
 263-422 2.29e-56

Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and similar proteins; The family includes RAB3IP and RAB3IL1, as well as Rab guanine nucleotide exchange factor SEC2 from yeast. RAB3IP, also called Rabin-3, or SSX2-interacting protein, or Rabin8, acts as a guanine nucleotide exchange factor (GEF) which promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. It mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. It modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. RAB3IL1, also called guanine nucleotide exchange factor for Rab-3A (GRAB), or Rab3A-interacting-like protein 1, or Rabin3-like 1, acts as a guanine nucleotide exchange factor (GEF) which promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. As a dual Rab-binding protein, RAB3IL1 could potentially link Rab3 and Rab11 and/or Rab8 and Rab11-mediated intracellular trafficking processes. It may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. It may also activate RAB8A and RAB8B. In addition, RAB3IL1 interacts with InsP6K1 and plays a role for InsP7 in vesicle exocytosis. SEC2 is a guanine nucleotide exchange factor for SEC4, catalyzing the dissociation of GDP from SEC4 and also potently promoting binding of GTP. Activation of SEC4 by SEC2 is needed for the directed transport of vesicles to sites of exocytosis. SEC2 binds the Rab GTPase YPT32 but does not have exchange activity on YPT32. The model corresponds to the Rab11a/Rab11b-binding region of family members which lies within the carboxy-terminus, a region distinct from their GEF domain and Rab3a-binding region.


Pssm-ID: 411031  Cd Length: 178  Bit Score: 183.72  E-value: 2.29e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361139 263 KEADLSLYNEFRSWKDEP-----TMDRTCPFLDKIYQEDIFPCLTFAKS----ELASAVLEAVENNTLSIEPVGLQPIRF 333
Cdd:cd21044     1 FEVDLVLFEEFQEFLKAPsslslSLLKSSPFLKRILAEDIEPCLRFDPAllnwLLKKRLLAAILENTLEIEPISGSTETS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361139 334 VK------ASAVECGGPKKCALTGQSK--PCRHRIRLGDSSCC-YYISPFCRYRITSVCNFFTYIRYIQQGLVKQQDVDQ 404
Cdd:cd21044    81 SSsnntapVSSPPPASPKKCALCGESRldACLYRLRLSDSDSEwYPICSYCRNRLRAVCDFFAYLRYIRQGLVKSRSIEK 160

                         170
                  ....*....|....*...
gi 1720361139 405 MFWEVMQLRKEMSLAKLG 422
Cdd:cd21044   161 LYLEILRLRLRMFLARLG 178
ATG16 pfam08614
Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for ...
 103-209 1.40e-04

Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway.


Pssm-ID: 462536 [Multi-domain]  Cd Length: 176  Bit Score: 42.23  E-value: 1.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361139 103 TKLTSRKDSCNAEREFLQGATITEASAGNDdifglSTDSLSRLRSPSVLEVREKGYeRLKEELAKAQR---EAHKMVREA 179
Cdd:pfam08614  10 NRLLDRTALLEAENAKLQSEPESVLPSTSS-----SKLSKASPQSASIQSLEQLLA-QLREELAELYRsrgELAQRLVDL 83

                          90       100       110
                  ....*....|....*....|....*....|
gi 1720361139 180 NVKQATAEKQLKEAQGKIDVLQAEVAALKT 209
Cdd:pfam08614  84 NEELQELEKKLREDERRLAALEAERAQLEE 113
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 158-208 2.59e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 42.89  E-value: 2.59e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1720361139 158 YERLKEELAKAQREAHKMVREANVKQATAEKQLKEAQGKIDVLQAEVAALK 208
Cdd:COG3883   145 LEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAE 195
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
151-209 5.59e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 41.81  E-value: 5.59e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720361139 151 LEVREKGYERLKEELAKAQRE----------AHKMVREANVKQATAEKQLKEAQGKIDVLQAEVAALKT 209
Cdd:COG4372    54 LEQAREELEQLEEELEQARSEleqleeeleeLNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQK 122
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 158-209 1.71e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 40.58  E-value: 1.71e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720361139 158 YERLKEELAKAQREAHKMVREANVKQATAEKQLKEAQGKIDVLQAEVAALKT 209
Cdd:COG3883   138 LKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSA 189
DivIVA COG3599
Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle ...
 140-208 2.29e-03

Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442818 [Multi-domain]  Cd Length: 125  Bit Score: 37.91  E-value: 2.29e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720361139 140 DSLSRlrspsVLEVREKGYERLKEElakAQREAHKMVREANVKqatAEKQLKEAQGKIDVLQAEVAALK 208
Cdd:COG3599    65 ETLQK-----TLVVAQETAEEVKEN---AEKEAELIIKEAELE---AEKIIEEAQEKARKIVREIEELK 122
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
151-222 2.84e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 39.50  E-value: 2.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361139 151 LEVREKGYERLKEELAKAQREAHKMVREANVKQA----------TAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPT 220
Cdd:COG4372   103 LESLQEEAEELQEELEELQKERQDLEQQRKQLEAqiaelqseiaEREEELKELEEQLESLQEELAALEQELQALSEAEAE 182


                  ..
gi 1720361139 221 QE 222
Cdd:COG4372   183 QA 184
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 151-211 3.73e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 39.43  E-value: 3.73e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720361139 151 LEVREKGYERLKEELAKAQREAHKMVREANVKQA---TAEKQLKEAQGKIDVLQAEVAALKTLV 211
Cdd:COG3883    18 IQAKQKELSELQAELEAAQAELDALQAELEELNEeynELQAELEALQAEIDKLQAEIAEAEAEI 81
Borrelia_P83 pfam05262
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.
 152-216 4.62e-03

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.


Pssm-ID: 114011 [Multi-domain]  Cd Length: 489  Bit Score: 39.22  E-value: 4.62e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720361139 152 EVREKGYERLKEELAKAQREAHKMVREANVKQATAEKQLKEAQGKidvLQAEVAALKTLVLSSSP 216
Cdd:pfam05262 209 QEDAKRAQQLKEELDKKQIDADKAQQKADFAQDNADKQRDEVRQK---QQEAKNLPKPADTSSPK 270
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 151-248 8.81e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 38.27  E-value: 8.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361139 151 LEVREKGYERLKEELAKAQREAHKMVREANVKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLAAAKTP 230
Cdd:COG3883   145 LEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAA 224

                          90
                  ....*....|....*...
gi 1720361139 231 FKRGHTRNKSTSSAMGGS 248
Cdd:COG3883   225 AAAAAAAAAAAAAAAAAA 242
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 151-208 9.08e-03

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 37.19  E-value: 9.08e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720361139 151 LEVREKGYERLKEELAKAQREahkmVREANVKQATAEK---QLKEAQGKIDVLQAEVAALK 208
Cdd:pfam13851  49 MSEIQQENKRLTEPLQKAQEE----VEELRKQLENYEKdkqSLKNLKARLKVLEKELKDLK 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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