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Conserved domains on  [gi|1720433272|ref|XP_030100589|]
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NCK-interacting protein with SH3 domain isoform X2 [Mus musculus]

Protein Classification

DUF2013 domain-containing protein( domain architecture ID 10559551)

DUF2013 domain-containing protein similar to Saccharomyces cerevisiae protein low dye-binding protein 17 (LDB17) that may be involved in protein-linked oligosaccharide phosphorylation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPIN90_LRD pfam09431
SPIN90/Ldb17, leucine-rich domain; This is the conserved leucine-rich domain (LRD) within the ...
 254-367 1.64e-44

SPIN90/Ldb17, leucine-rich domain; This is the conserved leucine-rich domain (LRD) within the C-terminal domain of SPIN90 (also known as NCK interacting protein with SH3 domain (NCKIPSD)) from animals, Ldb17 from budding yeasts and Dip1 from fission yeasts. Ldb17 is involved in the regulation of endocytosis in yeast. SPIN90 is an F-actin binding protein that regulates actin polymerization and endocytosis. It associates with and activates the Arp2/3 complex, without requiring a preformed actin filament. This LRD, within the C-terminal armadillo repeat (ARM) domain of SPIN90, is important for activation of Arp2/3 complex.


:

Pssm-ID: 462796  Cd Length: 135  Bit Score: 150.70  E-value: 1.64e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720433272 254 QNVIMAALSRHTNVKIFSEKLLLLLNRGDDPVRIFrhepqpphSVLKFLQDVFSSSATAAIFYHTDMMALIDITVRQIAD 333
Cdd:pfam09431  29 ENKVLKVLSRLSSSKTFGENLLLLLNREEDPVLQL--------LILKLLYLIFTTPETAEYFYTNDLKVLIDIFIRELND 100

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1720433272 334 LS-PGDKLRMEYLSLMHAVVRSTPYLQHRHRLSDL 367
Cdd:pfam09431 101 LSeEGEKLRHTYLRVLYPLLRNTQLSEHHYKRDDL 135
 
Name Accession Description Interval E-value
SPIN90_LRD pfam09431
SPIN90/Ldb17, leucine-rich domain; This is the conserved leucine-rich domain (LRD) within the ...
 254-367 1.64e-44

SPIN90/Ldb17, leucine-rich domain; This is the conserved leucine-rich domain (LRD) within the C-terminal domain of SPIN90 (also known as NCK interacting protein with SH3 domain (NCKIPSD)) from animals, Ldb17 from budding yeasts and Dip1 from fission yeasts. Ldb17 is involved in the regulation of endocytosis in yeast. SPIN90 is an F-actin binding protein that regulates actin polymerization and endocytosis. It associates with and activates the Arp2/3 complex, without requiring a preformed actin filament. This LRD, within the C-terminal armadillo repeat (ARM) domain of SPIN90, is important for activation of Arp2/3 complex.


Pssm-ID: 462796  Cd Length: 135  Bit Score: 150.70  E-value: 1.64e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720433272 254 QNVIMAALSRHTNVKIFSEKLLLLLNRGDDPVRIFrhepqpphSVLKFLQDVFSSSATAAIFYHTDMMALIDITVRQIAD 333
Cdd:pfam09431  29 ENKVLKVLSRLSSSKTFGENLLLLLNREEDPVLQL--------LILKLLYLIFTTPETAEYFYTNDLKVLIDIFIRELND 100

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1720433272 334 LS-PGDKLRMEYLSLMHAVVRSTPYLQHRHRLSDL 367
Cdd:pfam09431 101 LSeEGEKLRHTYLRVLYPLLRNTQLSEHHYKRDDL 135
 
Name Accession Description Interval E-value
SPIN90_LRD pfam09431
SPIN90/Ldb17, leucine-rich domain; This is the conserved leucine-rich domain (LRD) within the ...
 254-367 1.64e-44

SPIN90/Ldb17, leucine-rich domain; This is the conserved leucine-rich domain (LRD) within the C-terminal domain of SPIN90 (also known as NCK interacting protein with SH3 domain (NCKIPSD)) from animals, Ldb17 from budding yeasts and Dip1 from fission yeasts. Ldb17 is involved in the regulation of endocytosis in yeast. SPIN90 is an F-actin binding protein that regulates actin polymerization and endocytosis. It associates with and activates the Arp2/3 complex, without requiring a preformed actin filament. This LRD, within the C-terminal armadillo repeat (ARM) domain of SPIN90, is important for activation of Arp2/3 complex.


Pssm-ID: 462796  Cd Length: 135  Bit Score: 150.70  E-value: 1.64e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720433272 254 QNVIMAALSRHTNVKIFSEKLLLLLNRGDDPVRIFrhepqpphSVLKFLQDVFSSSATAAIFYHTDMMALIDITVRQIAD 333
Cdd:pfam09431  29 ENKVLKVLSRLSSSKTFGENLLLLLNREEDPVLQL--------LILKLLYLIFTTPETAEYFYTNDLKVLIDIFIRELND 100

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1720433272 334 LS-PGDKLRMEYLSLMHAVVRSTPYLQHRHRLSDL 367
Cdd:pfam09431 101 LSeEGEKLRHTYLRVLYPLLRNTQLSEHHYKRDDL 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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