|
Name |
Accession |
Description |
Interval |
E-value |
| ADAMTS_spacer1 |
pfam05986 |
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ... |
212-321 |
2.54e-32 |
|
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.
:
Pssm-ID: 461796 Cd Length: 115 Bit Score: 121.53 E-value: 2.54e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 212 TVSRTFKETEGQGYVDIGLIPAGAREILIEEVAEAANFLALRSeDPDKYFLNGGWTIQ-WNGDYRVAGTTFTYARKGN-W 289
Cdd:pfam05986 1 TVSGSFTEGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKN-VQGKYILNGKGSISlNPTYPSLLGTVLEYRRSLPaL 79
|
90 100 110
....*....|....*....|....*....|....*
gi 1720429992 290 ENLTSPGPTSEPVWIQLLFQ---EKNPGVHYQYTI 321
Cdd:pfam05986 80 EELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFI 114
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
1030-1085 |
2.64e-13 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
:
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 65.55 E-value: 2.64e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720429992 1030 WVVGPWGQCSAPCGGGVQRRLVRCVNTqTGLAEEDSDLCSHEAWPESSRPCATEDC 1085
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQK-GGGSIVPDSECSAQKKPPETQSCNLKPC 55
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
54-106 |
2.92e-13 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
:
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 65.30 E-value: 2.92e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1720429992 54 WSGWSAWSDCSRSCGVGVRSSERQCTQPVPKNRGKYCVGERKRSQLCNLPACP 106
Cdd:smart00209 1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
|
|
| ADAMTS_CR_2 |
pfam17771 |
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ... |
2-41 |
3.07e-12 |
|
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.
:
Pssm-ID: 465496 Cd Length: 68 Bit Score: 62.75 E-value: 3.07e-12
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1720429992 2 DDVCHTLWCSVGT--TCHSKLDAAVDGTSCGKNKWCLKGECV 41
Cdd:pfam17771 27 EDVCSKLWCSNPGgsTCTTKNLPAADGTPCGNKKWCLNGKCV 68
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
336-390 |
7.68e-12 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
:
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 61.31 E-value: 7.68e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720429992 336 WHYGPWSKCTVTCGTGVQRQSLYCM-ERQAGVVAEEYCNTLNRPDERQRkCSEEPC 390
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVqKGGGSIVPDSECSAQKKPPETQS-CNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
923-978 |
1.55e-10 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
:
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 57.46 E-value: 1.55e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720429992 923 WRTGNWSKCSRNCGGGSSTRDVQCVDTRDLRPLRPFHCqPGPTKPPNRQLCGTQPC 978
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSEC-SAQKKPPETQSCNLKPC 55
|
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
551-889 |
3.02e-10 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 64.96 E-value: 3.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 551 PHPDLVDNGGWTAPPHIRPTESPSDTPVPTAGALGAEAEDIQGSWSPSPLLSEASYSPP-----------GLEQTSINPL 619
Cdd:PHA03247 2601 PVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGrvsrprrarrlGRAAQASSPP 2680
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 620 ANFLTEEDTPMGAPELGFPSLPWPPASVDDMMTPVGPGNPDELLVKEDEQSPPSTPWSD-----RNKLSTDGNPLGHTSP 694
Cdd:PHA03247 2681 QRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPappavPAGPATPGGPARPARP 2760
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 695 ALPQSPI-PTQPSPPSISPTQASPSPDVVEVSTGWNAA---WDP------------VLEADLKPGHGELPSTVEVASPPL 758
Cdd:PHA03247 2761 PTTAGPPaPAPPAAPAAGPPRRLTRPAVASLSESRESLpspWDPadppaavlapaaALPPAASPAGPLPPPTSAQPTAPP 2840
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 759 LPMATVPGIWGRDSPLEPGTPTFSSPELSSQHLK--TLTMPGTLLLTVPTDLRSPGPSGQPQTPnlegtqsPGLLPTPAR 836
Cdd:PHA03247 2841 PPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKpaAPARPPVRRLARPAVSRSTESFALPPDQ-------PERPPQPQA 2913
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1720429992 837 ETQTNSSKDPEVQPL-QPSLEEDGDPADPLPARNASWQVGNWSQCSTTCGLGAI 889
Cdd:PHA03247 2914 PPPPQPQPQPPPPPQpQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGAL 2967
|
|
| ADAMTS_CR_3 super family |
cl41950 |
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ... |
112-210 |
1.51e-09 |
|
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.
The actual alignment was detected with superfamily member pfam19236:
Pssm-ID: 437068 Cd Length: 115 Bit Score: 56.64 E-value: 1.51e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 112 FRHTQCSQFDGMLYK-----GKLHKW---VPVPNDDNPCELHCRPSNSSNTEKLRDAVVDGTPCYQSRISRD----ICLN 179
Cdd:pfam19236 5 FMSQQCARTDGQPLRsspggASFYHWgaaVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDgtlsLCVL 84
|
90 100 110
....*....|....*....|....*....|.
gi 1720429992 180 GICKNVGCDFVIDSGAEEDRCGVCRGDGSTC 210
Cdd:pfam19236 85 GSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
|
|
| TSP1_ADAMTS super family |
cl40597 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
872-920 |
3.61e-09 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
The actual alignment was detected with superfamily member pfam19030:
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 53.61 E-value: 3.61e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1720429992 872 WQVGNWSQCSTTCGLGAIWRLVSCSSG------NDEDCTLASRPQPARHCHLRPC 920
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKgggsivPDSECSAQKKPPETQSCNLKPC 55
|
|
| TSP1_ADAMTS super family |
cl40597 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
394-450 |
2.19e-08 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
The actual alignment was detected with superfamily member pfam19030:
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 51.30 E-value: 2.19e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 1720429992 394 WWAGEWQPCSRSCGPeGLSRRAVFCIRSMGLDEQRAlelSACEHLPRPLAETPCNRH 450
Cdd:pfam19030 1 WVAGPWGECSVTCGG-GVQTRLVQCVQKGGGSIVPD---SECSAQKKPPETQSCNLK 53
|
|
| TSP1_ADAMTS super family |
cl40597 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
981-1027 |
3.53e-07 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
The actual alignment was detected with superfamily member pfam19030:
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 48.22 E-value: 3.53e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1720429992 981 WYTSSWRECSEACGGGEQQRLVTCPEPG--------LCEESLRPNNSRPCNTHPC 1027
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKGggsivpdsECSAQKKPPETQSCNLKPC 55
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| ADAMTS_spacer1 |
pfam05986 |
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ... |
212-321 |
2.54e-32 |
|
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.
Pssm-ID: 461796 Cd Length: 115 Bit Score: 121.53 E-value: 2.54e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 212 TVSRTFKETEGQGYVDIGLIPAGAREILIEEVAEAANFLALRSeDPDKYFLNGGWTIQ-WNGDYRVAGTTFTYARKGN-W 289
Cdd:pfam05986 1 TVSGSFTEGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKN-VQGKYILNGKGSISlNPTYPSLLGTVLEYRRSLPaL 79
|
90 100 110
....*....|....*....|....*....|....*
gi 1720429992 290 ENLTSPGPTSEPVWIQLLFQ---EKNPGVHYQYTI 321
Cdd:pfam05986 80 EELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFI 114
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
1030-1085 |
2.64e-13 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 65.55 E-value: 2.64e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720429992 1030 WVVGPWGQCSAPCGGGVQRRLVRCVNTqTGLAEEDSDLCSHEAWPESSRPCATEDC 1085
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQK-GGGSIVPDSECSAQKKPPETQSCNLKPC 55
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
54-106 |
2.92e-13 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 65.30 E-value: 2.92e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1720429992 54 WSGWSAWSDCSRSCGVGVRSSERQCTQPVPKNRGKYCVGERKRSQLCNLPACP 106
Cdd:smart00209 1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
|
|
| ADAMTS_CR_2 |
pfam17771 |
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ... |
2-41 |
3.07e-12 |
|
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.
Pssm-ID: 465496 Cd Length: 68 Bit Score: 62.75 E-value: 3.07e-12
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1720429992 2 DDVCHTLWCSVGT--TCHSKLDAAVDGTSCGKNKWCLKGECV 41
Cdd:pfam17771 27 EDVCSKLWCSNPGgsTCTTKNLPAADGTPCGNKKWCLNGKCV 68
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
336-390 |
7.68e-12 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 61.31 E-value: 7.68e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720429992 336 WHYGPWSKCTVTCGTGVQRQSLYCM-ERQAGVVAEEYCNTLNRPDERQRkCSEEPC 390
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVqKGGGSIVPDSECSAQKKPPETQS-CNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
923-978 |
1.55e-10 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 57.46 E-value: 1.55e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720429992 923 WRTGNWSKCSRNCGGGSSTRDVQCVDTRDLRPLRPFHCqPGPTKPPNRQLCGTQPC 978
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSEC-SAQKKPPETQSCNLKPC 55
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
551-889 |
3.02e-10 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 64.96 E-value: 3.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 551 PHPDLVDNGGWTAPPHIRPTESPSDTPVPTAGALGAEAEDIQGSWSPSPLLSEASYSPP-----------GLEQTSINPL 619
Cdd:PHA03247 2601 PVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGrvsrprrarrlGRAAQASSPP 2680
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 620 ANFLTEEDTPMGAPELGFPSLPWPPASVDDMMTPVGPGNPDELLVKEDEQSPPSTPWSD-----RNKLSTDGNPLGHTSP 694
Cdd:PHA03247 2681 QRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPappavPAGPATPGGPARPARP 2760
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 695 ALPQSPI-PTQPSPPSISPTQASPSPDVVEVSTGWNAA---WDP------------VLEADLKPGHGELPSTVEVASPPL 758
Cdd:PHA03247 2761 PTTAGPPaPAPPAAPAAGPPRRLTRPAVASLSESRESLpspWDPadppaavlapaaALPPAASPAGPLPPPTSAQPTAPP 2840
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 759 LPMATVPGIWGRDSPLEPGTPTFSSPELSSQHLK--TLTMPGTLLLTVPTDLRSPGPSGQPQTPnlegtqsPGLLPTPAR 836
Cdd:PHA03247 2841 PPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKpaAPARPPVRRLARPAVSRSTESFALPPDQ-------PERPPQPQA 2913
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1720429992 837 ETQTNSSKDPEVQPL-QPSLEEDGDPADPLPARNASWQVGNWSQCSTTCGLGAI 889
Cdd:PHA03247 2914 PPPPQPQPQPPPPPQpQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGAL 2967
|
|
| ADAMTS_CR_3 |
pfam19236 |
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ... |
112-210 |
1.51e-09 |
|
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.
Pssm-ID: 437068 Cd Length: 115 Bit Score: 56.64 E-value: 1.51e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 112 FRHTQCSQFDGMLYK-----GKLHKW---VPVPNDDNPCELHCRPSNSSNTEKLRDAVVDGTPCYQSRISRD----ICLN 179
Cdd:pfam19236 5 FMSQQCARTDGQPLRsspggASFYHWgaaVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDgtlsLCVL 84
|
90 100 110
....*....|....*....|....*....|.
gi 1720429992 180 GICKNVGCDFVIDSGAEEDRCGVCRGDGSTC 210
Cdd:pfam19236 85 GSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
872-920 |
3.61e-09 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 53.61 E-value: 3.61e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1720429992 872 WQVGNWSQCSTTCGLGAIWRLVSCSSG------NDEDCTLASRPQPARHCHLRPC 920
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKgggsivPDSECSAQKKPPETQSCNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
394-450 |
2.19e-08 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 51.30 E-value: 2.19e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 1720429992 394 WWAGEWQPCSRSCGPeGLSRRAVFCIRSMGLDEQRAlelSACEHLPRPLAETPCNRH 450
Cdd:pfam19030 1 WVAGPWGECSVTCGG-GVQTRLVQCVQKGGGSIVPD---SECSAQKKPPETQSCNLK 53
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
981-1027 |
3.53e-07 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 48.22 E-value: 3.53e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1720429992 981 WYTSSWRECSEACGGGEQQRLVTCPEPG--------LCEESLRPNNSRPCNTHPC 1027
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKGggsivpdsECSAQKKPPETQSCNLKPC 55
|
|
| TSP_1 |
pfam00090 |
Thrombospondin type 1 domain; |
55-105 |
9.16e-07 |
|
Thrombospondin type 1 domain;
Pssm-ID: 459668 [Multi-domain] Cd Length: 49 Bit Score: 46.64 E-value: 9.16e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1720429992 55 SGWSAWSDCSRSCGVGVRSSERQCTQPVPKnrGKYCVGERKRSQLCNLPAC 105
Cdd:pfam00090 1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFPG--GEPCTGDDIETQACKMDKC 49
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
336-391 |
7.33e-05 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 41.42 E-value: 7.33e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720429992 336 WHYGPWSKCTVTCGTGVQRQSLYCmERQAGVVAEEYCNTlnrPDERQRKCSEEPCP 391
Cdd:smart00209 2 SEWSEWSPCSVTCGGGVQTRTRSC-CSPPPQNGGGPCTG---EDVETRACNEQPCP 53
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
1027-1086 |
3.33e-04 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 39.49 E-value: 3.33e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 1027 CTQWvvGPWGQCSAPCGGGVQRRLVRCVNtqtGLAEEDSDLCSHEAwpESSRPCATEDCE 1086
Cdd:smart00209 1 WSEW--SEWSPCSVTCGGGVQTRTRSCCS---PPPQNGGGPCTGED--VETRACNEQPCP 53
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
554-845 |
4.18e-04 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 44.52 E-value: 4.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 554 DLVDNGGWTAPPHIRPTESPSDTPVPTAGALGAEAEDiqgSWSPSPLLSEASYSPPgleqtsiNPLANFLTEEDTPMgap 633
Cdd:pfam05109 390 DITVSGLGTAPKTLIITRTATNATTTTHKVIFSKAPE---STTTSPTLNTTGFAAP-------NTTTGLPSSTHVPT--- 456
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 634 ELGFPSLPWPPASVDDMMTPVGPGNPdellvkedEQSPPSTPWSDRNKLSTDGNPLGHTSP-ALPQSPIP--TQPSPPSI 710
Cdd:pfam05109 457 NLTAPASTGPTVSTADVTSPTPAGTT--------SGASPVTPSPSPRDNGTESKAPDMTSPtSAVTTPTPnaTSPTPAVT 528
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 711 SPTQASPSPDVVEVSTgwnaawdpvLEADLKPGHGELPSTVEVASPPllPMATVPGIwGRDSP---LEPGTPTFSSP--- 784
Cdd:pfam05109 529 TPTPNATSPTLGKTSP---------TSAVTTPTPNATSPTPAVTTPT--PNATIPTL-GKTSPtsaVTTPTPNATSPtvg 596
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720429992 785 ELSSQHLKT-LTMPGT----LLLTVPTDLRSPGPSGQPQTPNlEGTQSPGLLPTPARETQTNSSKD 845
Cdd:pfam05109 597 ETSPQANTTnHTLGGTsstpVVTSPPKNATSAVTTGQHNITS-SSTSSMSLRPSSISETLSPSTSD 661
|
|
| PspC_subgroup_2 |
NF033839 |
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ... |
533-866 |
2.08e-03 |
|
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.
Pssm-ID: 468202 [Multi-domain] Cd Length: 557 Bit Score: 42.06 E-value: 2.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 533 DYNFINFHEDLS----YGSFEEPHPDLVDNggwtaPPHIRP-TESPSDTPVPTAGALGAEAEDI-QGSWSPSPLLSEASY 606
Cdd:NF033839 137 DEAVSKFEKDSSssssSGSSTKPETPQPEN-----PEHQKPtTPAPDTKPSPQPEGKKPSVPDInQEKEKAKLAVATYMS 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 607 SPPGLEQTSINPLANFLTEEDTPMGAPELGFPSLPwppaSVDDMMTPVGPGNP--------DELLVKEDEQSPPSTPWSD 678
Cdd:NF033839 212 KILDDIQKHHLQKEKHRQIVALIKELDELKKQALS----EIDNVNTKVEIENTvhkifadmDAVVTKFKKGLTQDTPKEP 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 679 RNKLSTDGNPLGHTSPALPQSPIPTQPSP--PSISPTQASPSPDVVEVSTGWNAAWDPVLEADlKPGHGELPST--VEVA 754
Cdd:NF033839 288 GNKKPSAPKPGMQPSPQPEKKEVKPEPETpkPEVKPQLEKPKPEVKPQPEKPKPEVKPQLETP-KPEVKPQPEKpkPEVK 366
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 755 SPPLLPMATVPGiwgrdsplEPGTPTFS-SPELSSQHLKTLTMPGTLLLTVPTDLRSPGPS--GQPQTPNLEGTQSPgll 831
Cdd:NF033839 367 PQPEKPKPEVKP--------QPETPKPEvKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEvkPQPEKPKPEVKPQP--- 435
|
330 340 350
....*....|....*....|....*....|....*...
gi 1720429992 832 PTPARETQTNSSK-DPEV--QPLQPSLEEDGDPADPLP 866
Cdd:NF033839 436 EKPKPEVKPQPEKpKPEVkpQPETPKPEVKPQPEKPKP 473
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| ADAMTS_spacer1 |
pfam05986 |
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ... |
212-321 |
2.54e-32 |
|
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.
Pssm-ID: 461796 Cd Length: 115 Bit Score: 121.53 E-value: 2.54e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 212 TVSRTFKETEGQGYVDIGLIPAGAREILIEEVAEAANFLALRSeDPDKYFLNGGWTIQ-WNGDYRVAGTTFTYARKGN-W 289
Cdd:pfam05986 1 TVSGSFTEGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKN-VQGKYILNGKGSISlNPTYPSLLGTVLEYRRSLPaL 79
|
90 100 110
....*....|....*....|....*....|....*
gi 1720429992 290 ENLTSPGPTSEPVWIQLLFQ---EKNPGVHYQYTI 321
Cdd:pfam05986 80 EELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFI 114
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
1030-1085 |
2.64e-13 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 65.55 E-value: 2.64e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720429992 1030 WVVGPWGQCSAPCGGGVQRRLVRCVNTqTGLAEEDSDLCSHEAWPESSRPCATEDC 1085
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQK-GGGSIVPDSECSAQKKPPETQSCNLKPC 55
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
54-106 |
2.92e-13 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 65.30 E-value: 2.92e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1720429992 54 WSGWSAWSDCSRSCGVGVRSSERQCTQPVPKNRGKYCVGERKRSQLCNLPACP 106
Cdd:smart00209 1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
|
|
| ADAMTS_CR_2 |
pfam17771 |
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ... |
2-41 |
3.07e-12 |
|
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.
Pssm-ID: 465496 Cd Length: 68 Bit Score: 62.75 E-value: 3.07e-12
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1720429992 2 DDVCHTLWCSVGT--TCHSKLDAAVDGTSCGKNKWCLKGECV 41
Cdd:pfam17771 27 EDVCSKLWCSNPGgsTCTTKNLPAADGTPCGNKKWCLNGKCV 68
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
336-390 |
7.68e-12 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 61.31 E-value: 7.68e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720429992 336 WHYGPWSKCTVTCGTGVQRQSLYCM-ERQAGVVAEEYCNTLNRPDERQRkCSEEPC 390
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVqKGGGSIVPDSECSAQKKPPETQS-CNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
923-978 |
1.55e-10 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 57.46 E-value: 1.55e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720429992 923 WRTGNWSKCSRNCGGGSSTRDVQCVDTRDLRPLRPFHCqPGPTKPPNRQLCGTQPC 978
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSEC-SAQKKPPETQSCNLKPC 55
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
551-889 |
3.02e-10 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 64.96 E-value: 3.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 551 PHPDLVDNGGWTAPPHIRPTESPSDTPVPTAGALGAEAEDIQGSWSPSPLLSEASYSPP-----------GLEQTSINPL 619
Cdd:PHA03247 2601 PVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGrvsrprrarrlGRAAQASSPP 2680
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 620 ANFLTEEDTPMGAPELGFPSLPWPPASVDDMMTPVGPGNPDELLVKEDEQSPPSTPWSD-----RNKLSTDGNPLGHTSP 694
Cdd:PHA03247 2681 QRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPappavPAGPATPGGPARPARP 2760
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 695 ALPQSPI-PTQPSPPSISPTQASPSPDVVEVSTGWNAA---WDP------------VLEADLKPGHGELPSTVEVASPPL 758
Cdd:PHA03247 2761 PTTAGPPaPAPPAAPAAGPPRRLTRPAVASLSESRESLpspWDPadppaavlapaaALPPAASPAGPLPPPTSAQPTAPP 2840
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 759 LPMATVPGIWGRDSPLEPGTPTFSSPELSSQHLK--TLTMPGTLLLTVPTDLRSPGPSGQPQTPnlegtqsPGLLPTPAR 836
Cdd:PHA03247 2841 PPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKpaAPARPPVRRLARPAVSRSTESFALPPDQ-------PERPPQPQA 2913
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1720429992 837 ETQTNSSKDPEVQPL-QPSLEEDGDPADPLPARNASWQVGNWSQCSTTCGLGAI 889
Cdd:PHA03247 2914 PPPPQPQPQPPPPPQpQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGAL 2967
|
|
| ADAMTS_CR_3 |
pfam19236 |
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ... |
112-210 |
1.51e-09 |
|
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.
Pssm-ID: 437068 Cd Length: 115 Bit Score: 56.64 E-value: 1.51e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 112 FRHTQCSQFDGMLYK-----GKLHKW---VPVPNDDNPCELHCRPSNSSNTEKLRDAVVDGTPCYQSRISRD----ICLN 179
Cdd:pfam19236 5 FMSQQCARTDGQPLRsspggASFYHWgaaVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDgtlsLCVL 84
|
90 100 110
....*....|....*....|....*....|.
gi 1720429992 180 GICKNVGCDFVIDSGAEEDRCGVCRGDGSTC 210
Cdd:pfam19236 85 GSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
497-913 |
1.59e-09 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 62.65 E-value: 1.59e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 497 PRPSPASSPKPvsisnaiDEEELDPPGPVfvddfyydynfinfhedlsygsfEEPHPDLVDNGGWTAPPhirPTESPSDT 576
Cdd:PHA03247 2609 RGPAPPSPLPP-------DTHAPDPPPPS-----------------------PSPAANEPDPHPPPTVP---PPERPRDD 2655
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 577 PVPTAGALGAEAEdiQGSWSPSPLLSEASYSPPGLEQTsINPLANFL---TEEDTPMGAPELGFPSLPWPPA-SVDDMMT 652
Cdd:PHA03247 2656 PAPGRVSRPRRAR--RLGRAAQASSPPQRPRRRAARPT-VGSLTSLAdppPPPPTPEPAPHALVSATPLPPGpAAARQAS 2732
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 653 PVGPGNPdellvkedeqSPPSTPwsdrNKLSTDGNPLGHTSPALPQSPI-PTQPSPPSISPTQASPSPDVVEVSTGWNAA 731
Cdd:PHA03247 2733 PALPAAP----------APPAVP----AGPATPGGPARPARPPTTAGPPaPAPPAAPAAGPPRRLTRPAVASLSESRESL 2798
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 732 ---WDP------------VLEADLKPGHGELPSTVEVASPPLLPMATVPGIWGRDSPLEPGTPTFSSPELSSQHLK--TL 794
Cdd:PHA03247 2799 pspWDPadppaavlapaaALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKpaAP 2878
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 795 TMPGTLLLTVPTDLRSPGPSGQPQTPnlegtqsPGLLPTPARETQTNsskdPEVQPLQPSLEEDGDPADPLPARNASWQV 874
Cdd:PHA03247 2879 ARPPVRRLARPAVSRSTESFALPPDQ-------PERPPQPQAPPPPQ----PQPQPPPPPQPQPPPPPPPRPQPPLAPTT 2947
|
410 420 430
....*....|....*....|....*....|....*....
gi 1720429992 875 GNWSQCSTTCGLGAIWRLVSCSSGNDEDCTLASRPQPAR 913
Cdd:PHA03247 2948 DPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSR 2986
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
872-920 |
3.61e-09 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 53.61 E-value: 3.61e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1720429992 872 WQVGNWSQCSTTCGLGAIWRLVSCSSG------NDEDCTLASRPQPARHCHLRPC 920
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKgggsivPDSECSAQKKPPETQSCNLKPC 55
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
563-864 |
6.08e-09 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 60.72 E-value: 6.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 563 APPHIRPTESPSDTPVPTAGALGAEAEDIQGSWSPSP-----------LLSEASYSPPGLEQTSINPLANFLT----EED 627
Cdd:PHA03247 2770 APPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADppaavlapaaaLPPAASPAGPLPPPTSAQPTAPPPPpgppPPS 2849
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 628 TPMG------------APELGFPSLPWPPA--SVDDMMTPVGPGNPDELLVKEDEQSPPSTPWSDRNKLSTDGNPlghtS 693
Cdd:PHA03247 2850 LPLGgsvapggdvrrrPPSRSPAAKPAAPArpPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPP----P 2925
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 694 PALPQSPIPTQPSPPSisptQASPSPDVVEVSTGWNAAWDPVLEAdLKPGHGELPSTVEVASPPLLPMATVPGIWGRDSP 773
Cdd:PHA03247 2926 PPQPQPPPPPPPRPQP----PLAPTTDPAGAGEPSGAVPQPWLGA-LVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHS 3000
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 774 LEPGTPTFSSPELssqHLKTLTMPGTLLLT--VPTDLR-SPGPSGQPQTPNLEGTQSPGLLPTParetqtnsSKDPEVQP 850
Cdd:PHA03247 3001 LSRVSSWASSLAL---HEETDPPPVSLKQTlwPPDDTEdSDADSLFDSDSERSDLEALDPLPPE--------PHDPFAHE 3069
|
330
....*....|....
gi 1720429992 851 LQPSLEEDGDPADP 864
Cdd:PHA03247 3070 PDPATPEAGARESP 3083
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
394-450 |
2.19e-08 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 51.30 E-value: 2.19e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 1720429992 394 WWAGEWQPCSRSCGPeGLSRRAVFCIRSMGLDEQRAlelSACEHLPRPLAETPCNRH 450
Cdd:pfam19030 1 WVAGPWGECSVTCGG-GVQTRLVQCVQKGGGSIVPD---SECSAQKKPPETQSCNLK 53
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
563-867 |
1.42e-07 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 56.10 E-value: 1.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 563 APPHIRPTE-----SPSDTPVPTAGA-LGAEAEDIQGSWSPSPLLSEASYSP-PGLEQTSINPLANfLTEEDTpmGAPEL 635
Cdd:PHA03247 2477 APVYRRPAEarfpfAAGAAPDPGGGGpPDPDAPPAPSRLAPAILPDEPVGEPvHPRMLTWIRGLEE-LASDDA--GDPPP 2553
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 636 GFPSLPWPPASVDDMMTPVGPGNPDELLVKEDEQSPPSTPWSDRNKlsTDGNPLGhtSPALPQSPIPTQPSPPSISPTQA 715
Cdd:PHA03247 2554 PLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPR--APVDDRG--DPRGPAPPSPLPPDTHAPDPPPP 2629
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 716 SPSPDVVEVSTGWNAAWDPVLEADLKPGHGEL---------------PSTVEVASPPLLPMATVPGIWGRDSPLEPGTPT 780
Cdd:PHA03247 2630 SPSPAANEPDPHPPPTVPPPERPRDDPAPGRVsrprrarrlgraaqaSSPPQRPRRRAARPTVGSLTSLADPPPPPPTPE 2709
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 781 fSSPELSSQHLKTLTMPGTLLLTVPTDLRSPGPSGQPQTPNLEGTQS-PGLLPTPARETQTNSSKDP-----------EV 848
Cdd:PHA03247 2710 -PAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPArPARPPTTAGPPAPAPPAAPaagpprrltrpAV 2788
|
330
....*....|....*....
gi 1720429992 849 QPLQPSLEEDGDPADPLPA 867
Cdd:PHA03247 2789 ASLSESRESLPSPWDPADP 2807
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
981-1027 |
3.53e-07 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 48.22 E-value: 3.53e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1720429992 981 WYTSSWRECSEACGGGEQQRLVTCPEPG--------LCEESLRPNNSRPCNTHPC 1027
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKGggsivpdsECSAQKKPPETQSCNLKPC 55
|
|
| TSP_1 |
pfam00090 |
Thrombospondin type 1 domain; |
55-105 |
9.16e-07 |
|
Thrombospondin type 1 domain;
Pssm-ID: 459668 [Multi-domain] Cd Length: 49 Bit Score: 46.64 E-value: 9.16e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1720429992 55 SGWSAWSDCSRSCGVGVRSSERQCTQPVPKnrGKYCVGERKRSQLCNLPAC 105
Cdd:pfam00090 1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFPG--GEPCTGDDIETQACKMDKC 49
|
|
| TSP1_spondin |
pfam19028 |
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ... |
55-105 |
2.68e-06 |
|
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.
Pssm-ID: 465948 Cd Length: 52 Bit Score: 45.35 E-value: 2.68e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1720429992 55 SGWSAWSDCSRSCGVGVRSSERQCTQPvPKNRGKYCvGERKRSQLCNLPAC 105
Cdd:pfam19028 4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLPPC 52
|
|
| PLN03209 |
PLN03209 |
translocon at the inner envelope of chloroplast subunit 62; Provisional |
628-867 |
4.01e-05 |
|
translocon at the inner envelope of chloroplast subunit 62; Provisional
Pssm-ID: 178748 [Multi-domain] Cd Length: 576 Bit Score: 47.61 E-value: 4.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 628 TPMGAPELGFPSLPWPPASvddmmtPVGPGNPDELLVKEDEQSPPSTPwSDR---NKLSTDGNPLghtSPAL-------P 697
Cdd:PLN03209 314 TPMEELLAKIPSQRVPPKE------SDAADGPKPVPTKPVTPEAPSPP-IEEeppQPKAVVPRPL---SPYTayedlkpP 383
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 698 QSPIPTQPS--PPSISPTQASPSPDVVEVSTGWNAAWD-PVLEA------------------DLKPGHGELPSTVEVASP 756
Cdd:PLN03209 384 TSPIPTPPSssPASSKSVDAVAKPAEPDVVPSPGSASNvPEVEPaqveakktrplspyaryeDLKPPTSPSPTAPTGVSP 463
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 757 PLLPMATVPGIWGRDSPLEPGTPTFSSPELSSQHLKTLTMPGTLLLTVPTDLrSPGPSGQPQTPNLEGTQSPGLLPTPAR 836
Cdd:PLN03209 464 SVSSTSSVPAVPDTAPATAATDAAAPPPANMRPLSPYAVYDDLKPPTSPSPA-APVGKVAPSSTNEVVKVGNSAPPTALA 542
|
250 260 270
....*....|....*....|....*....|...
gi 1720429992 837 ETQTNssKDPEVQPLQP--SLEEDGDPADPLPA 867
Cdd:PLN03209 543 DEQHH--AQPKPRPLSPytMYEDLKPPTSPTPS 573
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
566-863 |
5.86e-05 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 47.38 E-value: 5.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 566 HIRPTESPSDTPVPTAG-----ALGAEAEDIQGSWSPSpllseaSYSPPGLEQTSINPLANFLTEEDTPMGAPELG-FPS 639
Cdd:PTZ00449 507 HDEPPEGPEASGLPPKApgdkeGEEGEHEDSKESDEPK------EGGKPGETKEGEVGKKPGPAKEHKPSKIPTLSkKPE 580
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 640 LPWPPASVDDMMTPVGPGNPdelLVKEDEQSPPSTPWSDRNKL-STDGNPLGHTSPALPQSPI----PTQPSPPSISPTQ 714
Cdd:PTZ00449 581 FPKDPKHPKDPEEPKKPKRP---RSAQRPTRPKSPKLPELLDIpKSPKRPESPKSPKRPPPPQrpssPERPEGPKIIKSP 657
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 715 ASP-SPDVvevstgwnaAWDPVLEADLKPGHGELPSTVEVASPPLLPMATVPGIWGRDSPLEPGTPTFSSPELSSQHLKT 793
Cdd:PTZ00449 658 KPPkSPKP---------PFDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLPRD 728
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 794 LTMPgtllLTVPTDLRSPGPS-GQPQTPNLE----------GTQSPGLLP----TPARETQTNSSKDPEVQPLQPSLEED 858
Cdd:PTZ00449 729 EEFP----FEPIGDPDAEQPDdIEFFTPPEEertffhetpaDTPLPDILAeefkEEDIHAETGEPDEAMKRPDSPSEHED 804
|
....*
gi 1720429992 859 GDPAD 863
Cdd:PTZ00449 805 KPPGD 809
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
336-391 |
7.33e-05 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 41.42 E-value: 7.33e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720429992 336 WHYGPWSKCTVTCGTGVQRQSLYCmERQAGVVAEEYCNTlnrPDERQRKCSEEPCP 391
Cdd:smart00209 2 SEWSEWSPCSVTCGGGVQTRTRSC-CSPPPQNGGGPCTG---EDVETRACNEQPCP 53
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
1027-1086 |
3.33e-04 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 39.49 E-value: 3.33e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 1027 CTQWvvGPWGQCSAPCGGGVQRRLVRCVNtqtGLAEEDSDLCSHEAwpESSRPCATEDCE 1086
Cdd:smart00209 1 WSEW--SEWSPCSVTCGGGVQTRTRSCCS---PPPQNGGGPCTGED--VETRACNEQPCP 53
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
554-845 |
4.18e-04 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 44.52 E-value: 4.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 554 DLVDNGGWTAPPHIRPTESPSDTPVPTAGALGAEAEDiqgSWSPSPLLSEASYSPPgleqtsiNPLANFLTEEDTPMgap 633
Cdd:pfam05109 390 DITVSGLGTAPKTLIITRTATNATTTTHKVIFSKAPE---STTTSPTLNTTGFAAP-------NTTTGLPSSTHVPT--- 456
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 634 ELGFPSLPWPPASVDDMMTPVGPGNPdellvkedEQSPPSTPWSDRNKLSTDGNPLGHTSP-ALPQSPIP--TQPSPPSI 710
Cdd:pfam05109 457 NLTAPASTGPTVSTADVTSPTPAGTT--------SGASPVTPSPSPRDNGTESKAPDMTSPtSAVTTPTPnaTSPTPAVT 528
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 711 SPTQASPSPDVVEVSTgwnaawdpvLEADLKPGHGELPSTVEVASPPllPMATVPGIwGRDSP---LEPGTPTFSSP--- 784
Cdd:pfam05109 529 TPTPNATSPTLGKTSP---------TSAVTTPTPNATSPTPAVTTPT--PNATIPTL-GKTSPtsaVTTPTPNATSPtvg 596
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720429992 785 ELSSQHLKT-LTMPGT----LLLTVPTDLRSPGPSGQPQTPNlEGTQSPGLLPTPARETQTNSSKD 845
Cdd:pfam05109 597 ETSPQANTTnHTLGGTsstpVVTSPPKNATSAVTTGQHNITS-SSTSSMSLRPSSISETLSPSTSD 661
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
57-105 |
4.64e-04 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 39.36 E-value: 4.64e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1720429992 57 WSA--WSDCSRSCGVGVRSSERQCTQPVPK--NRGKYCVGERK--RSQLCNLPAC 105
Cdd:pfam19030 1 WVAgpWGECSVTCGGGVQTRLVQCVQKGGGsiVPDSECSAQKKppETQSCNLKPC 55
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
638-854 |
1.13e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 43.22 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 638 PSLPWPPASVDD----MMTPVGPGNPDELLVKEDEQSPPSTPWSDRNKLSTDGNPLGHTSpalpqspIPTQPSPPSISPT 713
Cdd:pfam03154 146 PSIPSPQDNESDsdssAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPS-------VPPQGSPATSQPP 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 714 QASPSPdvvevstgwnaawdpvleadlKPGHGELPSTVEVaSPPLLPMAtvpgiwgrDSPLEPGTPTFSSPELSSQHLKT 793
Cdd:pfam03154 219 NQTQST---------------------AAPHTLIQQTPTL-HPQRLPSP--------HPPLQPMTQPPPPSQVSPQPLPQ 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 794 LTMPGTL------LLTVPTDLRSPGP---------SGQPQTPNLEGTQSPG----LLPTPARETQTNSSKDPEVQPLQPS 854
Cdd:pfam03154 269 PSLHGQMppmphsLQTGPSHMQHPVPpqpfpltpqSSQSQVPPGPSPAAPGqsqqRIHTPPSQSQLQSQQPPREQPLPPA 348
|
|
| PspC_subgroup_2 |
NF033839 |
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ... |
533-866 |
2.08e-03 |
|
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.
Pssm-ID: 468202 [Multi-domain] Cd Length: 557 Bit Score: 42.06 E-value: 2.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 533 DYNFINFHEDLS----YGSFEEPHPDLVDNggwtaPPHIRP-TESPSDTPVPTAGALGAEAEDI-QGSWSPSPLLSEASY 606
Cdd:NF033839 137 DEAVSKFEKDSSssssSGSSTKPETPQPEN-----PEHQKPtTPAPDTKPSPQPEGKKPSVPDInQEKEKAKLAVATYMS 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 607 SPPGLEQTSINPLANFLTEEDTPMGAPELGFPSLPwppaSVDDMMTPVGPGNP--------DELLVKEDEQSPPSTPWSD 678
Cdd:NF033839 212 KILDDIQKHHLQKEKHRQIVALIKELDELKKQALS----EIDNVNTKVEIENTvhkifadmDAVVTKFKKGLTQDTPKEP 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 679 RNKLSTDGNPLGHTSPALPQSPIPTQPSP--PSISPTQASPSPDVVEVSTGWNAAWDPVLEADlKPGHGELPST--VEVA 754
Cdd:NF033839 288 GNKKPSAPKPGMQPSPQPEKKEVKPEPETpkPEVKPQLEKPKPEVKPQPEKPKPEVKPQLETP-KPEVKPQPEKpkPEVK 366
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 755 SPPLLPMATVPGiwgrdsplEPGTPTFS-SPELSSQHLKTLTMPGTLLLTVPTDLRSPGPS--GQPQTPNLEGTQSPgll 831
Cdd:NF033839 367 PQPEKPKPEVKP--------QPETPKPEvKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEvkPQPEKPKPEVKPQP--- 435
|
330 340 350
....*....|....*....|....*....|....*...
gi 1720429992 832 PTPARETQTNSSK-DPEV--QPLQPSLEEDGDPADPLP 866
Cdd:NF033839 436 EKPKPEVKPQPEKpKPEVkpQPETPKPEVKPQPEKPKP 473
|
|
| DUF4045 |
pfam13254 |
Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. ... |
607-871 |
3.50e-03 |
|
Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. This domain family is found in bacteria and eukaryotes, and is typically between 384 and 430 amino acids in length.
Pssm-ID: 433066 [Multi-domain] Cd Length: 415 Bit Score: 41.31 E-value: 3.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 607 SPPGLEQT--------SINPLANFLTEEDTPMGAPELGFP-SLPWPPAS------VDDMMTPVGPGNPDELLVKedeqsp 671
Cdd:pfam13254 32 LPPGLSRQnsfasnrgSVAGPSGSLSPGLSPTKLSREGSPeSTSRPSSShseatiVRHSKDDERPSTPDEGFVK------ 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 672 PSTPWSDRNKLSTDGNPLGHTSPALPQSPiptqPSPPSI------SPTQASpspdvvevstgwnaaWdpvLEADL-KPgh 744
Cdd:pfam13254 106 PALPRHSRSSSALSNTGSEEDSPSLPTSP----PSPSKTmdpkrwSPTKSS---------------W---LESALnRP-- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 745 gELPSTVEVASPPLLP--MATVPGI--------WGRDSPLEPGTPT-FSSPELSSQHLKTLTMPGTLLLTVPTdlrSPGP 813
Cdd:pfam13254 162 -ESPKPKAQPSQPAQPawMKELNKIrqsrasvdLGRPNSFKEVTPVgLMRSPAPGGHSKSPSVSGISADSSPT---KEEP 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1720429992 814 SGQPQTPNLEGTQSPGLLPTPARETQTNSSKDPEVQPLQPSLEEDGDPADPLPARNAS 871
Cdd:pfam13254 238 SEEADTLSTDKEQSPAPTSASEPPPKTKELPKDSEEPAAPSKSAEASTEKKEPDTESS 295
|
|
| PLN03209 |
PLN03209 |
translocon at the inner envelope of chloroplast subunit 62; Provisional |
491-751 |
5.51e-03 |
|
translocon at the inner envelope of chloroplast subunit 62; Provisional
Pssm-ID: 178748 [Multi-domain] Cd Length: 576 Bit Score: 40.68 E-value: 5.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 491 IPNQLAPRPSP--ASSPKPVSISNAIDE-----EELDPPGPVFVDDfyydynfinfhEDLS-YGSFEEPHPDlvdnggwT 562
Cdd:PLN03209 323 IPSQRVPPKESdaADGPKPVPTKPVTPEapsppIEEEPPQPKAVVP-----------RPLSpYTAYEDLKPP-------T 384
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 563 APPHIRPTESPSDTPVPTAGALGAEAEDIQgswSPSPLLSEASYSPPGLEQTSINPLANFLTEED-TPMGAPELGFPSLP 641
Cdd:PLN03209 385 SPIPTPPSSSPASSKSVDAVAKPAEPDVVP---SPGSASNVPEVEPAQVEAKKTRPLSPYARYEDlKPPTSPSPTAPTGV 461
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 642 WPPASVDDMMTPVGPGNPDELLVKEDEQSPPSTPWSDRNKLSTDGNPLGHTSPALPQSPIPTQPSPPsiSPTQASPSPDV 721
Cdd:PLN03209 462 SPSVSSTSSVPAVPDTAPATAATDAAAPPPANMRPLSPYAVYDDLKPPTSPSPAAPVGKVAPSSTNE--VVKVGNSAPPT 539
|
250 260 270
....*....|....*....|....*....|....*.
gi 1720429992 722 VEVSTGWNAAWDP------VLEADLKPGHGELPSTV 751
Cdd:PLN03209 540 ALADEQHHAQPKPrplspyTMYEDLKPPTSPTPSPV 575
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
551-722 |
7.28e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 40.52 E-value: 7.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 551 PHPDLVDNGGWTAPPHI---RPTESPSDTPVPTA-GALGAEAEDIQGSWSPSPL--------LSEASYSPPGLEQTSINP 618
Cdd:pfam03154 362 PIPQLPNPQSHKHPPHLsgpSPFQMNSNLPPPPAlKPLSSLSTHHPPSAHPPPLqlmpqsqqLPPPPAQPPVLTQSQSLP 441
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 619 L--ANFLTEEDTPMGAPELGFPSLPWPPASVDDMMTPVGP---GNPDELLVKEDEQSPPSTPWSDRNKLSTDGNPLGHTS 693
Cdd:pfam03154 442 PpaASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPptsTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKE 521
|
170 180
....*....|....*....|....*....
gi 1720429992 694 PALPQSPIPTQPSPPSISPtqaSPSPDVV 722
Cdd:pfam03154 522 EALDEAEEPESPPPPPRSP---SPEPTVV 547
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
551-745 |
8.48e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 40.69 E-value: 8.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 551 PHPDLVDNGGWTAPPHIRP--TESPSDTPVPTAGALG----AEAEDIQGSWSPSPLLSE--ASYSPPGLEQTSINPLANF 622
Cdd:PHA03247 2806 DPPAAVLAPAAALPPAASPagPLPPPTSAQPTAPPPPpgppPPSLPLGGSVAPGGDVRRrpPSRSPAAKPAAPARPPVRR 2885
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 623 LTEEDTPMGAPELGFPSLPWPPASVDDMMTPvgPGNPDELLVKEDEQSPPSTPWSDRNKLSTDGNP-------------- 688
Cdd:PHA03247 2886 LARPAVSRSTESFALPPDQPERPPQPQAPPP--PQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPagagepsgavpqpw 2963
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1720429992 689 LGHTSPALPQSPIPTQPSPPSISPTQASPSPDVVEVSTGWNAAWDPVLEADLKPGHG 745
Cdd:PHA03247 2964 LGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPP 3020
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| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
492-836 |
8.77e-03 |
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Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 40.14 E-value: 8.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 492 PNQLAPRPSPASSPKPVSISNAIDEEELdPPGPvfvddfyydynfinfhEDLSYGSFEEPHPdlvdngGWTAPPHIRPTE 571
Cdd:pfam03154 248 PLQPMTQPPPPSQVSPQPLPQPSLHGQM-PPMP----------------HSLQTGPSHMQHP------VPPQPFPLTPQS 304
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 572 SPSDTPVPTAGALGAEAEdiQGSWSPSPLLSEASYSPPgleqtsinplanflteEDTPMGAPELGFPSLPWPPAS-VDDM 650
Cdd:pfam03154 305 SQSQVPPGPSPAAPGQSQ--QRIHTPPSQSQLQSQQPP----------------REQPLPPAPLSMPHIKPPPTTpIPQL 366
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170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 651 MTPVGPGNPDELLVKEDEQS----PPSTPWSDRNKLSTDGNPLGHTSPA--LPQS-PIPTQPS-PPSISPTQASPSPDVV 722
Cdd:pfam03154 367 PNPQSHKHPPHLSGPSPFQMnsnlPPPPALKPLSSLSTHHPPSAHPPPLqlMPQSqQLPPPPAqPPVLTQSQSLPPPAAS 446
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250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429992 723 EVSTGwnaAWDPVLEADLKPGHGELPStvevASPPLLPmatvpgiwgrdsplePGTPTFSSPELSSQHLKTLTMPGTLLL 802
Cdd:pfam03154 447 HPPTS---GLHQVPSQSPFPQHPFVPG----GPPPITP---------------PSGPPTSTSSAMPGIQPPSSASVSSSG 504
|
330 340 350
....*....|....*....|....*....|....
gi 1720429992 803 TVPTDLRSPGPSGQPQTPNLEGTQSPGLLPTPAR 836
Cdd:pfam03154 505 PVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPR 538
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