|
Name |
Accession |
Description |
Interval |
E-value |
| ADAMTS_spacer1 |
pfam05986 |
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ... |
212-321 |
2.63e-32 |
|
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.
:
Pssm-ID: 461796 Cd Length: 115 Bit Score: 121.53 E-value: 2.63e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 212 TVSRTFKETEGQGYVDIGLIPAGAREILIEEVAEAANFLALRSeDPDKYFLNGGWTIQ-WNGDYRVAGTTFTYARKGN-W 289
Cdd:pfam05986 1 TVSGSFTEGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKN-VQGKYILNGKGSISlNPTYPSLLGTVLEYRRSLPaL 79
|
90 100 110
....*....|....*....|....*....|....*
gi 1720429990 290 ENLTSPGPTSEPVWIQLLFQ---EKNPGVHYQYTI 321
Cdd:pfam05986 80 EELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFI 114
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
1072-1127 |
3.36e-13 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
:
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 65.17 E-value: 3.36e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720429990 1072 WVVGPWGQCSAPCGGGVQRRLVRCVNTqTGLAEEDSDLCSHEAWPESSRPCATEDC 1127
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQK-GGGSIVPDSECSAQKKPPETQSCNLKPC 55
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
54-106 |
4.10e-13 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
:
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 64.92 E-value: 4.10e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1720429990 54 WSGWSAWSDCSRSCGVGVRSSERQCTQPVPKNRGKYCVGERKRSQLCNLPACP 106
Cdd:smart00209 1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
|
|
| ADAMTS_CR_2 |
pfam17771 |
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ... |
2-41 |
4.44e-12 |
|
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.
:
Pssm-ID: 465496 Cd Length: 68 Bit Score: 62.36 E-value: 4.44e-12
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1720429990 2 DDVCHTLWCSVGT--TCHSKLDAAVDGTSCGKNKWCLKGECV 41
Cdd:pfam17771 27 EDVCSKLWCSNPGgsTCTTKNLPAADGTPCGNKKWCLNGKCV 68
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
336-390 |
1.06e-11 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
:
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 60.93 E-value: 1.06e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720429990 336 WHYGPWSKCTVTCGTGVQRQSLYCM-ERQAGVVAEEYCNTLNRPDERQRkCSEEPC 390
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVqKGGGSIVPDSECSAQKKPPETQS-CNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
965-1020 |
1.97e-10 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
:
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 57.46 E-value: 1.97e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720429990 965 WRTGNWSKCSRNCGGGSSTRDVQCVDTRDLRPLRPFHCqPGPTKPPNRQLCGTQPC 1020
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSEC-SAQKKPPETQSCNLKPC 55
|
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
593-931 |
2.36e-10 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 65.34 E-value: 2.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 593 PHPDLVDNGGWTAPPHIRPTESPSDTPVPTAGALGAEAEDIQGSWSPSPLLSEASYSPPGLE------------------ 654
Cdd:PHA03247 2601 PVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSrprrarrlgraaqasspp 2680
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 655 --------QTSINPLANFL---TEEDTPMGAPELGFPSLPWPPA-SVDDMMTPVGPGNPdellvkedeqSPPSTPwsdrN 722
Cdd:PHA03247 2681 qrprrraaRPTVGSLTSLAdppPPPPTPEPAPHALVSATPLPPGpAAARQASPALPAAP----------APPAVP----A 2746
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 723 KLSTDGNPLGHTSPALPQSPI-PTQPSPPSISPTQASPSPDVVEVSTGWNAA---WDP------------VLEADLKPGH 786
Cdd:PHA03247 2747 GPATPGGPARPARPPTTAGPPaPAPPAAPAAGPPRRLTRPAVASLSESRESLpspWDPadppaavlapaaALPPAASPAG 2826
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 787 GELPSTVEVASPPLLPMATVPGIWGRDSPLEPGTPTFSSPELSSQHLK--TLTMPGTLLLTVPTDLRSPGPSGQPQTPnl 864
Cdd:PHA03247 2827 PLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKpaAPARPPVRRLARPAVSRSTESFALPPDQ-- 2904
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720429990 865 egtqsPGLLPTPARETQTNSSKDPEVQPL-QPSLEEDGDPADPLPARNASWQVGNWSQCSTTCGLGAI 931
Cdd:PHA03247 2905 -----PERPPQPQAPPPPQPQPQPPPPPQpQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGAL 2967
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
457-505 |
9.69e-10 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
:
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 55.15 E-value: 9.69e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1720429990 457 WGVGNWSQCSVTCGAGIRQRSVLCI---NNTDVP---CDEAERPITETFCFLQPC 505
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVqkgGGSIVPdseCSAQKKPPETQSCNLKPC 55
|
|
| ADAMTS_CR_3 super family |
cl41950 |
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ... |
112-210 |
1.90e-09 |
|
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.
The actual alignment was detected with superfamily member pfam19236:
Pssm-ID: 437068 Cd Length: 115 Bit Score: 56.64 E-value: 1.90e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 112 FRHTQCSQFDGMLYK-----GKLHKW---VPVPNDDNPCELHCRPSNSSNTEKLRDAVVDGTPCYQSRISRD----ICLN 179
Cdd:pfam19236 5 FMSQQCARTDGQPLRsspggASFYHWgaaVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDgtlsLCVL 84
|
90 100 110
....*....|....*....|....*....|.
gi 1720429990 180 GICKNVGCDFVIDSGAEEDRCGVCRGDGSTC 210
Cdd:pfam19236 85 GSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
|
|
| TSP1_ADAMTS super family |
cl40597 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
914-962 |
4.38e-09 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
The actual alignment was detected with superfamily member pfam19030:
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 53.61 E-value: 4.38e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1720429990 914 WQVGNWSQCSTTCGLGAIWRLVSCSSG------NDEDCTLASRPQPARHCHLRPC 962
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKgggsivPDSECSAQKKPPETQSCNLKPC 55
|
|
| TSP1_ADAMTS super family |
cl40597 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
394-450 |
2.78e-08 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
The actual alignment was detected with superfamily member pfam19030:
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 51.30 E-value: 2.78e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 1720429990 394 WWAGEWQPCSRSCGPeGLSRRAVFCIRSMGLDEQRAlelSACEHLPRPLAETPCNRH 450
Cdd:pfam19030 1 WVAGPWGECSVTCGG-GVQTRLVQCVQKGGGSIVPD---SECSAQKKPPETQSCNLK 53
|
|
| TSP1_ADAMTS super family |
cl40597 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
1023-1069 |
4.25e-07 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
The actual alignment was detected with superfamily member pfam19030:
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 47.83 E-value: 4.25e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1720429990 1023 WYTSSWRECSEACGGGEQQRLVTCPEPG--------LCEESLRPNNSRPCNTHPC 1069
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKGggsivpdsECSAQKKPPETQSCNLKPC 55
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| ADAMTS_spacer1 |
pfam05986 |
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ... |
212-321 |
2.63e-32 |
|
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.
Pssm-ID: 461796 Cd Length: 115 Bit Score: 121.53 E-value: 2.63e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 212 TVSRTFKETEGQGYVDIGLIPAGAREILIEEVAEAANFLALRSeDPDKYFLNGGWTIQ-WNGDYRVAGTTFTYARKGN-W 289
Cdd:pfam05986 1 TVSGSFTEGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKN-VQGKYILNGKGSISlNPTYPSLLGTVLEYRRSLPaL 79
|
90 100 110
....*....|....*....|....*....|....*
gi 1720429990 290 ENLTSPGPTSEPVWIQLLFQ---EKNPGVHYQYTI 321
Cdd:pfam05986 80 EELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFI 114
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
1072-1127 |
3.36e-13 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 65.17 E-value: 3.36e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720429990 1072 WVVGPWGQCSAPCGGGVQRRLVRCVNTqTGLAEEDSDLCSHEAWPESSRPCATEDC 1127
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQK-GGGSIVPDSECSAQKKPPETQSCNLKPC 55
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
54-106 |
4.10e-13 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 64.92 E-value: 4.10e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1720429990 54 WSGWSAWSDCSRSCGVGVRSSERQCTQPVPKNRGKYCVGERKRSQLCNLPACP 106
Cdd:smart00209 1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
|
|
| ADAMTS_CR_2 |
pfam17771 |
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ... |
2-41 |
4.44e-12 |
|
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.
Pssm-ID: 465496 Cd Length: 68 Bit Score: 62.36 E-value: 4.44e-12
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1720429990 2 DDVCHTLWCSVGT--TCHSKLDAAVDGTSCGKNKWCLKGECV 41
Cdd:pfam17771 27 EDVCSKLWCSNPGgsTCTTKNLPAADGTPCGNKKWCLNGKCV 68
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
336-390 |
1.06e-11 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 60.93 E-value: 1.06e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720429990 336 WHYGPWSKCTVTCGTGVQRQSLYCM-ERQAGVVAEEYCNTLNRPDERQRkCSEEPC 390
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVqKGGGSIVPDSECSAQKKPPETQS-CNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
965-1020 |
1.97e-10 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 57.46 E-value: 1.97e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720429990 965 WRTGNWSKCSRNCGGGSSTRDVQCVDTRDLRPLRPFHCqPGPTKPPNRQLCGTQPC 1020
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSEC-SAQKKPPETQSCNLKPC 55
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
593-931 |
2.36e-10 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 65.34 E-value: 2.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 593 PHPDLVDNGGWTAPPHIRPTESPSDTPVPTAGALGAEAEDIQGSWSPSPLLSEASYSPPGLE------------------ 654
Cdd:PHA03247 2601 PVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSrprrarrlgraaqasspp 2680
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 655 --------QTSINPLANFL---TEEDTPMGAPELGFPSLPWPPA-SVDDMMTPVGPGNPdellvkedeqSPPSTPwsdrN 722
Cdd:PHA03247 2681 qrprrraaRPTVGSLTSLAdppPPPPTPEPAPHALVSATPLPPGpAAARQASPALPAAP----------APPAVP----A 2746
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 723 KLSTDGNPLGHTSPALPQSPI-PTQPSPPSISPTQASPSPDVVEVSTGWNAA---WDP------------VLEADLKPGH 786
Cdd:PHA03247 2747 GPATPGGPARPARPPTTAGPPaPAPPAAPAAGPPRRLTRPAVASLSESRESLpspWDPadppaavlapaaALPPAASPAG 2826
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 787 GELPSTVEVASPPLLPMATVPGIWGRDSPLEPGTPTFSSPELSSQHLK--TLTMPGTLLLTVPTDLRSPGPSGQPQTPnl 864
Cdd:PHA03247 2827 PLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKpaAPARPPVRRLARPAVSRSTESFALPPDQ-- 2904
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720429990 865 egtqsPGLLPTPARETQTNSSKDPEVQPL-QPSLEEDGDPADPLPARNASWQVGNWSQCSTTCGLGAI 931
Cdd:PHA03247 2905 -----PERPPQPQAPPPPQPQPQPPPPPQpQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGAL 2967
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
457-505 |
9.69e-10 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 55.15 E-value: 9.69e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1720429990 457 WGVGNWSQCSVTCGAGIRQRSVLCI---NNTDVP---CDEAERPITETFCFLQPC 505
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVqkgGGSIVPdseCSAQKKPPETQSCNLKPC 55
|
|
| ADAMTS_CR_3 |
pfam19236 |
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ... |
112-210 |
1.90e-09 |
|
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.
Pssm-ID: 437068 Cd Length: 115 Bit Score: 56.64 E-value: 1.90e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 112 FRHTQCSQFDGMLYK-----GKLHKW---VPVPNDDNPCELHCRPSNSSNTEKLRDAVVDGTPCYQSRISRD----ICLN 179
Cdd:pfam19236 5 FMSQQCARTDGQPLRsspggASFYHWgaaVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDgtlsLCVL 84
|
90 100 110
....*....|....*....|....*....|.
gi 1720429990 180 GICKNVGCDFVIDSGAEEDRCGVCRGDGSTC 210
Cdd:pfam19236 85 GSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
914-962 |
4.38e-09 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 53.61 E-value: 4.38e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1720429990 914 WQVGNWSQCSTTCGLGAIWRLVSCSSG------NDEDCTLASRPQPARHCHLRPC 962
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKgggsivPDSECSAQKKPPETQSCNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
394-450 |
2.78e-08 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 51.30 E-value: 2.78e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 1720429990 394 WWAGEWQPCSRSCGPeGLSRRAVFCIRSMGLDEQRAlelSACEHLPRPLAETPCNRH 450
Cdd:pfam19030 1 WVAGPWGECSVTCGG-GVQTRLVQCVQKGGGSIVPD---SECSAQKKPPETQSCNLK 53
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
1023-1069 |
4.25e-07 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 47.83 E-value: 4.25e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1720429990 1023 WYTSSWRECSEACGGGEQQRLVTCPEPG--------LCEESLRPNNSRPCNTHPC 1069
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKGggsivpdsECSAQKKPPETQSCNLKPC 55
|
|
| TSP_1 |
pfam00090 |
Thrombospondin type 1 domain; |
55-105 |
1.19e-06 |
|
Thrombospondin type 1 domain;
Pssm-ID: 459668 [Multi-domain] Cd Length: 49 Bit Score: 46.26 E-value: 1.19e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1720429990 55 SGWSAWSDCSRSCGVGVRSSERQCTQPVPKnrGKYCVGERKRSQLCNLPAC 105
Cdd:pfam00090 1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFPG--GEPCTGDDIETQACKMDKC 49
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
336-391 |
9.35e-05 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 41.03 E-value: 9.35e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720429990 336 WHYGPWSKCTVTCGTGVQRQSLYCmERQAGVVAEEYCNTlnrPDERQRKCSEEPCP 391
Cdd:smart00209 2 SEWSEWSPCSVTCGGGVQTRTRSC-CSPPPQNGGGPCTG---EDVETRACNEQPCP 53
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
596-887 |
3.16e-04 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 44.91 E-value: 3.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 596 DLVDNGGWTAPPHIRPTESPSDTPVPTAGALGAEAEDiqgSWSPSPLLSEASYSPPgleqtsiNPLANFLTEEDTPMgap 675
Cdd:pfam05109 390 DITVSGLGTAPKTLIITRTATNATTTTHKVIFSKAPE---STTTSPTLNTTGFAAP-------NTTTGLPSSTHVPT--- 456
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 676 ELGFPSLPWPPASVDDMMTPVGPGNPdellvkedEQSPPSTPWSDRNKLSTDGNPLGHTSP-ALPQSPIP--TQPSPPSI 752
Cdd:pfam05109 457 NLTAPASTGPTVSTADVTSPTPAGTT--------SGASPVTPSPSPRDNGTESKAPDMTSPtSAVTTPTPnaTSPTPAVT 528
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 753 SPTQASPSPDVVEVSTgwnaawdpvLEADLKPGHGELPSTVEVASPPllPMATVPGIwGRDSP---LEPGTPTFSSP--- 826
Cdd:pfam05109 529 TPTPNATSPTLGKTSP---------TSAVTTPTPNATSPTPAVTTPT--PNATIPTL-GKTSPtsaVTTPTPNATSPtvg 596
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720429990 827 ELSSQHLKT-LTMPGT----LLLTVPTDLRSPGPSGQPQTPNlEGTQSPGLLPTPARETQTNSSKD 887
Cdd:pfam05109 597 ETSPQANTTnHTLGGTsstpVVTSPPKNATSAVTTGQHNITS-SSTSSMSLRPSSISETLSPSTSD 661
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
1069-1128 |
4.47e-04 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 39.11 E-value: 4.47e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 1069 CTQWvvGPWGQCSAPCGGGVQRRLVRCVNtqtGLAEEDSDLCSHEAwpESSRPCATEDCE 1128
Cdd:smart00209 1 WSEW--SEWSPCSVTCGGGVQTRTRSCCS---PPPQNGGGPCTGED--VETRACNEQPCP 53
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
455-505 |
5.55e-04 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 39.11 E-value: 5.55e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1720429990 455 STWGvgNWSQCSVTCGAGIRQRSVLCINNTDVPCDEA-ERPITET-FCFLQPC 505
Cdd:smart00209 2 SEWS--EWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPcTGEDVETrACNEQPC 52
|
|
| PspC_subgroup_2 |
NF033839 |
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ... |
575-908 |
1.16e-03 |
|
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.
Pssm-ID: 468202 [Multi-domain] Cd Length: 557 Bit Score: 42.83 E-value: 1.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 575 DYNFINFHEDLS----YGSFEEPHPDLVDNggwtaPPHIRP-TESPSDTPVPTAGALGAEAEDI-QGSWSPSPLLSEASY 648
Cdd:NF033839 137 DEAVSKFEKDSSssssSGSSTKPETPQPEN-----PEHQKPtTPAPDTKPSPQPEGKKPSVPDInQEKEKAKLAVATYMS 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 649 SPPGLEQTSINPLANFLTEEDTPMGAPELGFPSLPwppaSVDDMMTPVGPGNP--------DELLVKEDEQSPPSTPWSD 720
Cdd:NF033839 212 KILDDIQKHHLQKEKHRQIVALIKELDELKKQALS----EIDNVNTKVEIENTvhkifadmDAVVTKFKKGLTQDTPKEP 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 721 RNKLSTDGNPLGHTSPALPQSPIPTQPSP--PSISPTQASPSPDVVEVSTGWNAAWDPVLEADlKPGHGELPST--VEVA 796
Cdd:NF033839 288 GNKKPSAPKPGMQPSPQPEKKEVKPEPETpkPEVKPQLEKPKPEVKPQPEKPKPEVKPQLETP-KPEVKPQPEKpkPEVK 366
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 797 SPPLLPMATVPGiwgrdsplEPGTPTFS-SPELSSQHLKTLTMPGTLLLTVPTDLRSPGPS--GQPQTPNLEGTQSPgll 873
Cdd:NF033839 367 PQPEKPKPEVKP--------QPETPKPEvKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEvkPQPEKPKPEVKPQP--- 435
|
330 340 350
....*....|....*....|....*....|....*...
gi 1720429990 874 PTPARETQTNSSK-DPEV--QPLQPSLEEDGDPADPLP 908
Cdd:NF033839 436 EKPKPEVKPQPEKpKPEVkpQPETPKPEVKPQPEKPKP 473
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| ADAMTS_spacer1 |
pfam05986 |
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ... |
212-321 |
2.63e-32 |
|
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.
Pssm-ID: 461796 Cd Length: 115 Bit Score: 121.53 E-value: 2.63e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 212 TVSRTFKETEGQGYVDIGLIPAGAREILIEEVAEAANFLALRSeDPDKYFLNGGWTIQ-WNGDYRVAGTTFTYARKGN-W 289
Cdd:pfam05986 1 TVSGSFTEGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKN-VQGKYILNGKGSISlNPTYPSLLGTVLEYRRSLPaL 79
|
90 100 110
....*....|....*....|....*....|....*
gi 1720429990 290 ENLTSPGPTSEPVWIQLLFQ---EKNPGVHYQYTI 321
Cdd:pfam05986 80 EELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFI 114
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
1072-1127 |
3.36e-13 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 65.17 E-value: 3.36e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720429990 1072 WVVGPWGQCSAPCGGGVQRRLVRCVNTqTGLAEEDSDLCSHEAWPESSRPCATEDC 1127
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQK-GGGSIVPDSECSAQKKPPETQSCNLKPC 55
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
54-106 |
4.10e-13 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 64.92 E-value: 4.10e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1720429990 54 WSGWSAWSDCSRSCGVGVRSSERQCTQPVPKNRGKYCVGERKRSQLCNLPACP 106
Cdd:smart00209 1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
|
|
| ADAMTS_CR_2 |
pfam17771 |
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ... |
2-41 |
4.44e-12 |
|
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.
Pssm-ID: 465496 Cd Length: 68 Bit Score: 62.36 E-value: 4.44e-12
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1720429990 2 DDVCHTLWCSVGT--TCHSKLDAAVDGTSCGKNKWCLKGECV 41
Cdd:pfam17771 27 EDVCSKLWCSNPGgsTCTTKNLPAADGTPCGNKKWCLNGKCV 68
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
336-390 |
1.06e-11 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 60.93 E-value: 1.06e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720429990 336 WHYGPWSKCTVTCGTGVQRQSLYCM-ERQAGVVAEEYCNTLNRPDERQRkCSEEPC 390
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVqKGGGSIVPDSECSAQKKPPETQS-CNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
965-1020 |
1.97e-10 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 57.46 E-value: 1.97e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720429990 965 WRTGNWSKCSRNCGGGSSTRDVQCVDTRDLRPLRPFHCqPGPTKPPNRQLCGTQPC 1020
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSEC-SAQKKPPETQSCNLKPC 55
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
593-931 |
2.36e-10 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 65.34 E-value: 2.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 593 PHPDLVDNGGWTAPPHIRPTESPSDTPVPTAGALGAEAEDIQGSWSPSPLLSEASYSPPGLE------------------ 654
Cdd:PHA03247 2601 PVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSrprrarrlgraaqasspp 2680
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 655 --------QTSINPLANFL---TEEDTPMGAPELGFPSLPWPPA-SVDDMMTPVGPGNPdellvkedeqSPPSTPwsdrN 722
Cdd:PHA03247 2681 qrprrraaRPTVGSLTSLAdppPPPPTPEPAPHALVSATPLPPGpAAARQASPALPAAP----------APPAVP----A 2746
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 723 KLSTDGNPLGHTSPALPQSPI-PTQPSPPSISPTQASPSPDVVEVSTGWNAA---WDP------------VLEADLKPGH 786
Cdd:PHA03247 2747 GPATPGGPARPARPPTTAGPPaPAPPAAPAAGPPRRLTRPAVASLSESRESLpspWDPadppaavlapaaALPPAASPAG 2826
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 787 GELPSTVEVASPPLLPMATVPGIWGRDSPLEPGTPTFSSPELSSQHLK--TLTMPGTLLLTVPTDLRSPGPSGQPQTPnl 864
Cdd:PHA03247 2827 PLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKpaAPARPPVRRLARPAVSRSTESFALPPDQ-- 2904
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720429990 865 egtqsPGLLPTPARETQTNSSKDPEVQPL-QPSLEEDGDPADPLPARNASWQVGNWSQCSTTCGLGAI 931
Cdd:PHA03247 2905 -----PERPPQPQAPPPPQPQPQPPPPPQpQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGAL 2967
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
457-505 |
9.69e-10 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 55.15 E-value: 9.69e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1720429990 457 WGVGNWSQCSVTCGAGIRQRSVLCI---NNTDVP---CDEAERPITETFCFLQPC 505
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVqkgGGSIVPdseCSAQKKPPETQSCNLKPC 55
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
539-955 |
1.13e-09 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 63.03 E-value: 1.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 539 PRPSPASSPKPvsisnaiDEEELDPPGPVfvddfyydynfinfhedlsygsfEEPHPDLVDNGGWTAPPhirPTESPSDT 618
Cdd:PHA03247 2609 RGPAPPSPLPP-------DTHAPDPPPPS-----------------------PSPAANEPDPHPPPTVP---PPERPRDD 2655
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 619 PVPTAGALGAEAEdiQGSWSPSPLLSEASYSPPGLEQTsINPLANFL---TEEDTPMGAPELGFPSLPWPPA-SVDDMMT 694
Cdd:PHA03247 2656 PAPGRVSRPRRAR--RLGRAAQASSPPQRPRRRAARPT-VGSLTSLAdppPPPPTPEPAPHALVSATPLPPGpAAARQAS 2732
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 695 PVGPGNPdellvkedeqSPPSTPwsdrNKLSTDGNPLGHTSPALPQSPI-PTQPSPPSISPTQASPSPDVVEVSTGWNAA 773
Cdd:PHA03247 2733 PALPAAP----------APPAVP----AGPATPGGPARPARPPTTAGPPaPAPPAAPAAGPPRRLTRPAVASLSESRESL 2798
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 774 ---WDP------------VLEADLKPGHGELPSTVEVASPPLLPMATVPGIWGRDSPLEPGTPTFSSPELSSQHLK--TL 836
Cdd:PHA03247 2799 pspWDPadppaavlapaaALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKpaAP 2878
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 837 TMPGTLLLTVPTDLRSPGPSGQPQTPnlegtqsPGLLPTPARETQTNsskdPEVQPLQPSLEEDGDPADPLPARNASWQV 916
Cdd:PHA03247 2879 ARPPVRRLARPAVSRSTESFALPPDQ-------PERPPQPQAPPPPQ----PQPQPPPPPQPQPPPPPPPRPQPPLAPTT 2947
|
410 420 430
....*....|....*....|....*....|....*....
gi 1720429990 917 GNWSQCSTTCGLGAIWRLVSCSSGNDEDCTLASRPQPAR 955
Cdd:PHA03247 2948 DPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSR 2986
|
|
| ADAMTS_CR_3 |
pfam19236 |
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ... |
112-210 |
1.90e-09 |
|
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.
Pssm-ID: 437068 Cd Length: 115 Bit Score: 56.64 E-value: 1.90e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 112 FRHTQCSQFDGMLYK-----GKLHKW---VPVPNDDNPCELHCRPSNSSNTEKLRDAVVDGTPCYQSRISRD----ICLN 179
Cdd:pfam19236 5 FMSQQCARTDGQPLRsspggASFYHWgaaVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDgtlsLCVL 84
|
90 100 110
....*....|....*....|....*....|.
gi 1720429990 180 GICKNVGCDFVIDSGAEEDRCGVCRGDGSTC 210
Cdd:pfam19236 85 GSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
605-906 |
4.32e-09 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 61.11 E-value: 4.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 605 APPHIRPTESPSDTPVPTAGALGAEAEDIQGSWSPSP-----------LLSEASYSPPGLEQTSINPLANFLT----EED 669
Cdd:PHA03247 2770 APPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADppaavlapaaaLPPAASPAGPLPPPTSAQPTAPPPPpgppPPS 2849
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 670 TPMG------------APELGFPSLPWPPA--SVDDMMTPVGPGNPDELLVKEDEQSPPSTPWSDRNKLSTDGNPlghtS 735
Cdd:PHA03247 2850 LPLGgsvapggdvrrrPPSRSPAAKPAAPArpPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPP----P 2925
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 736 PALPQSPIPTQPSPPSisptQASPSPDVVEVSTGWNAAWDPVLEAdLKPGHGELPSTVEVASPPLLPMATVPGIWGRDSP 815
Cdd:PHA03247 2926 PPQPQPPPPPPPRPQP----PLAPTTDPAGAGEPSGAVPQPWLGA-LVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHS 3000
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 816 LEPGTPTFSSPELssqHLKTLTMPGTLLLT--VPTDLR-SPGPSGQPQTPNLEGTQSPGLLPTParetqtnsSKDPEVQP 892
Cdd:PHA03247 3001 LSRVSSWASSLAL---HEETDPPPVSLKQTlwPPDDTEdSDADSLFDSDSERSDLEALDPLPPE--------PHDPFAHE 3069
|
330
....*....|....
gi 1720429990 893 LQPSLEEDGDPADP 906
Cdd:PHA03247 3070 PDPATPEAGARESP 3083
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
914-962 |
4.38e-09 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 53.61 E-value: 4.38e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1720429990 914 WQVGNWSQCSTTCGLGAIWRLVSCSSG------NDEDCTLASRPQPARHCHLRPC 962
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKgggsivPDSECSAQKKPPETQSCNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
394-450 |
2.78e-08 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 51.30 E-value: 2.78e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 1720429990 394 WWAGEWQPCSRSCGPeGLSRRAVFCIRSMGLDEQRAlelSACEHLPRPLAETPCNRH 450
Cdd:pfam19030 1 WVAGPWGECSVTCGG-GVQTRLVQCVQKGGGSIVPD---SECSAQKKPPETQSCNLK 53
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
605-909 |
1.01e-07 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 56.87 E-value: 1.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 605 APPHIRPTE--SPSdTPVPTAGALGAEAEDIQGSWSPS----PLLSEASYSPP----------GLEQtsinplanfLTEE 668
Cdd:PHA03247 2477 APVYRRPAEarFPF-AAGAAPDPGGGGPPDPDAPPAPSrlapAILPDEPVGEPvhprmltwirGLEE---------LASD 2546
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 669 DTpmGAPELGFPSLPWPPASVDDMMTPVGPGNPDELLVKEDEQSPPSTPWSDRNKlsTDGNPLGhtSPALPQSPIPTQPS 748
Cdd:PHA03247 2547 DA--GDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPR--APVDDRG--DPRGPAPPSPLPPD 2620
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 749 PPSISPTQASPSPDVVEVSTGWNAAWDPVLEADLKPGHGEL---------------PSTVEVASPPLLPMATVPGIWGRD 813
Cdd:PHA03247 2621 THAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVsrprrarrlgraaqaSSPPQRPRRRAARPTVGSLTSLAD 2700
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 814 SPLEPGTPTfSSPELSSQHLKTLTMPGTLLLTVPTDLRSPGPSGQPQTPNLEGTQS-PGLLPTPARETQTNSSKDP---- 888
Cdd:PHA03247 2701 PPPPPPTPE-PAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPArPARPPTTAGPPAPAPPAAPaagp 2779
|
330 340
....*....|....*....|....*...
gi 1720429990 889 -------EVQPLQPSLEEDGDPADPLPA 909
Cdd:PHA03247 2780 prrltrpAVASLSESRESLPSPWDPADP 2807
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
1023-1069 |
4.25e-07 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 47.83 E-value: 4.25e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1720429990 1023 WYTSSWRECSEACGGGEQQRLVTCPEPG--------LCEESLRPNNSRPCNTHPC 1069
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKGggsivpdsECSAQKKPPETQSCNLKPC 55
|
|
| TSP_1 |
pfam00090 |
Thrombospondin type 1 domain; |
55-105 |
1.19e-06 |
|
Thrombospondin type 1 domain;
Pssm-ID: 459668 [Multi-domain] Cd Length: 49 Bit Score: 46.26 E-value: 1.19e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1720429990 55 SGWSAWSDCSRSCGVGVRSSERQCTQPVPKnrGKYCVGERKRSQLCNLPAC 105
Cdd:pfam00090 1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFPG--GEPCTGDDIETQACKMDKC 49
|
|
| TSP1_spondin |
pfam19028 |
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ... |
55-105 |
3.35e-06 |
|
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.
Pssm-ID: 465948 Cd Length: 52 Bit Score: 45.35 E-value: 3.35e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1720429990 55 SGWSAWSDCSRSCGVGVRSSERQCTQPvPKNRGKYCvGERKRSQLCNLPAC 105
Cdd:pfam19028 4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLPPC 52
|
|
| PLN03209 |
PLN03209 |
translocon at the inner envelope of chloroplast subunit 62; Provisional |
670-909 |
3.38e-05 |
|
translocon at the inner envelope of chloroplast subunit 62; Provisional
Pssm-ID: 178748 [Multi-domain] Cd Length: 576 Bit Score: 48.00 E-value: 3.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 670 TPMGAPELGFPSLPWPPASvddmmtPVGPGNPDELLVKEDEQSPPSTPwSDR---NKLSTDGNPLghtSPAL-------P 739
Cdd:PLN03209 314 TPMEELLAKIPSQRVPPKE------SDAADGPKPVPTKPVTPEAPSPP-IEEeppQPKAVVPRPL---SPYTayedlkpP 383
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 740 QSPIPTQPS--PPSISPTQASPSPDVVEVSTGWNAAWD-PVLEA------------------DLKPGHGELPSTVEVASP 798
Cdd:PLN03209 384 TSPIPTPPSssPASSKSVDAVAKPAEPDVVPSPGSASNvPEVEPaqveakktrplspyaryeDLKPPTSPSPTAPTGVSP 463
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 799 PLLPMATVPGIWGRDSPLEPGTPTFSSPELSSQHLKTLTMPGTLLLTVPTDLrSPGPSGQPQTPNLEGTQSPGLLPTPAR 878
Cdd:PLN03209 464 SVSSTSSVPAVPDTAPATAATDAAAPPPANMRPLSPYAVYDDLKPPTSPSPA-APVGKVAPSSTNEVVKVGNSAPPTALA 542
|
250 260 270
....*....|....*....|....*....|...
gi 1720429990 879 ETQTNssKDPEVQPLQP--SLEEDGDPADPLPA 909
Cdd:PLN03209 543 DEQHH--AQPKPRPLSPytMYEDLKPPTSPTPS 573
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
608-905 |
4.50e-05 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 47.76 E-value: 4.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 608 HIRPTESPSDTPVPTAG-----ALGAEAEDIQGSWSPSpllseaSYSPPGLEQTSINPLANFLTEEDTPMGAPELG-FPS 681
Cdd:PTZ00449 507 HDEPPEGPEASGLPPKApgdkeGEEGEHEDSKESDEPK------EGGKPGETKEGEVGKKPGPAKEHKPSKIPTLSkKPE 580
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 682 LPWPPASVDDMMTPVGPGNPdelLVKEDEQSPPSTPWSDRNKL-STDGNPLGHTSPALPQSPI----PTQPSPPSISPTQ 756
Cdd:PTZ00449 581 FPKDPKHPKDPEEPKKPKRP---RSAQRPTRPKSPKLPELLDIpKSPKRPESPKSPKRPPPPQrpssPERPEGPKIIKSP 657
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 757 ASP-SPDVvevstgwnaAWDPVLEADLKPGHGELPSTVEVASPPLLPMATVPGIWGRDSPLEPGTPTFSSPELSSQHLKT 835
Cdd:PTZ00449 658 KPPkSPKP---------PFDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLPRD 728
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 836 LTMPgtllLTVPTDLRSPGPS-GQPQTPNLE----------GTQSPGLLP----TPARETQTNSSKDPEVQPLQPSLEED 900
Cdd:PTZ00449 729 EEFP----FEPIGDPDAEQPDdIEFFTPPEEertffhetpaDTPLPDILAeefkEEDIHAETGEPDEAMKRPDSPSEHED 804
|
....*
gi 1720429990 901 GDPAD 905
Cdd:PTZ00449 805 KPPGD 809
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
336-391 |
9.35e-05 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 41.03 E-value: 9.35e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720429990 336 WHYGPWSKCTVTCGTGVQRQSLYCmERQAGVVAEEYCNTlnrPDERQRKCSEEPCP 391
Cdd:smart00209 2 SEWSEWSPCSVTCGGGVQTRTRSC-CSPPPQNGGGPCTG---EDVETRACNEQPCP 53
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
596-887 |
3.16e-04 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 44.91 E-value: 3.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 596 DLVDNGGWTAPPHIRPTESPSDTPVPTAGALGAEAEDiqgSWSPSPLLSEASYSPPgleqtsiNPLANFLTEEDTPMgap 675
Cdd:pfam05109 390 DITVSGLGTAPKTLIITRTATNATTTTHKVIFSKAPE---STTTSPTLNTTGFAAP-------NTTTGLPSSTHVPT--- 456
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 676 ELGFPSLPWPPASVDDMMTPVGPGNPdellvkedEQSPPSTPWSDRNKLSTDGNPLGHTSP-ALPQSPIP--TQPSPPSI 752
Cdd:pfam05109 457 NLTAPASTGPTVSTADVTSPTPAGTT--------SGASPVTPSPSPRDNGTESKAPDMTSPtSAVTTPTPnaTSPTPAVT 528
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 753 SPTQASPSPDVVEVSTgwnaawdpvLEADLKPGHGELPSTVEVASPPllPMATVPGIwGRDSP---LEPGTPTFSSP--- 826
Cdd:pfam05109 529 TPTPNATSPTLGKTSP---------TSAVTTPTPNATSPTPAVTTPT--PNATIPTL-GKTSPtsaVTTPTPNATSPtvg 596
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720429990 827 ELSSQHLKT-LTMPGT----LLLTVPTDLRSPGPSGQPQTPNlEGTQSPGLLPTPARETQTNSSKD 887
Cdd:pfam05109 597 ETSPQANTTnHTLGGTsstpVVTSPPKNATSAVTTGQHNITS-SSTSSMSLRPSSISETLSPSTSD 661
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
1069-1128 |
4.47e-04 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 39.11 E-value: 4.47e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 1069 CTQWvvGPWGQCSAPCGGGVQRRLVRCVNtqtGLAEEDSDLCSHEAwpESSRPCATEDCE 1128
Cdd:smart00209 1 WSEW--SEWSPCSVTCGGGVQTRTRSCCS---PPPQNGGGPCTGED--VETRACNEQPCP 53
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
57-105 |
5.52e-04 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 38.97 E-value: 5.52e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1720429990 57 WSA--WSDCSRSCGVGVRSSERQCTQPVPK--NRGKYCVGERK--RSQLCNLPAC 105
Cdd:pfam19030 1 WVAgpWGECSVTCGGGVQTRLVQCVQKGGGsiVPDSECSAQKKppETQSCNLKPC 55
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
455-505 |
5.55e-04 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 39.11 E-value: 5.55e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1720429990 455 STWGvgNWSQCSVTCGAGIRQRSVLCINNTDVPCDEA-ERPITET-FCFLQPC 505
Cdd:smart00209 2 SEWS--EWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPcTGEDVETrACNEQPC 52
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
680-896 |
8.10e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 43.60 E-value: 8.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 680 PSLPWPPASVDD----MMTPVGPGNPDELLVKEDEQSPPSTPWSDRNKLSTDGNPLGHTSpalpqspIPTQPSPPSISPT 755
Cdd:pfam03154 146 PSIPSPQDNESDsdssAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPS-------VPPQGSPATSQPP 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 756 QASPSPdvvevstgwnaawdpvleadlKPGHGELPSTVEVaSPPLLPMAtvpgiwgrDSPLEPGTPTFSSPELSSQHLKT 835
Cdd:pfam03154 219 NQTQST---------------------AAPHTLIQQTPTL-HPQRLPSP--------HPPLQPMTQPPPPSQVSPQPLPQ 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 836 LTMPGTL------LLTVPTDLRSPGP---------SGQPQTPNLEGTQSPG----LLPTPARETQTNSSKDPEVQPLQPS 896
Cdd:pfam03154 269 PSLHGQMppmphsLQTGPSHMQHPVPpqpfpltpqSSQSQVPPGPSPAAPGqsqqRIHTPPSQSQLQSQQPPREQPLPPA 348
|
|
| PspC_subgroup_2 |
NF033839 |
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ... |
575-908 |
1.16e-03 |
|
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.
Pssm-ID: 468202 [Multi-domain] Cd Length: 557 Bit Score: 42.83 E-value: 1.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 575 DYNFINFHEDLS----YGSFEEPHPDLVDNggwtaPPHIRP-TESPSDTPVPTAGALGAEAEDI-QGSWSPSPLLSEASY 648
Cdd:NF033839 137 DEAVSKFEKDSSssssSGSSTKPETPQPEN-----PEHQKPtTPAPDTKPSPQPEGKKPSVPDInQEKEKAKLAVATYMS 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 649 SPPGLEQTSINPLANFLTEEDTPMGAPELGFPSLPwppaSVDDMMTPVGPGNP--------DELLVKEDEQSPPSTPWSD 720
Cdd:NF033839 212 KILDDIQKHHLQKEKHRQIVALIKELDELKKQALS----EIDNVNTKVEIENTvhkifadmDAVVTKFKKGLTQDTPKEP 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 721 RNKLSTDGNPLGHTSPALPQSPIPTQPSP--PSISPTQASPSPDVVEVSTGWNAAWDPVLEADlKPGHGELPST--VEVA 796
Cdd:NF033839 288 GNKKPSAPKPGMQPSPQPEKKEVKPEPETpkPEVKPQLEKPKPEVKPQPEKPKPEVKPQLETP-KPEVKPQPEKpkPEVK 366
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 797 SPPLLPMATVPGiwgrdsplEPGTPTFS-SPELSSQHLKTLTMPGTLLLTVPTDLRSPGPS--GQPQTPNLEGTQSPgll 873
Cdd:NF033839 367 PQPEKPKPEVKP--------QPETPKPEvKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEvkPQPEKPKPEVKPQP--- 435
|
330 340 350
....*....|....*....|....*....|....*...
gi 1720429990 874 PTPARETQTNSSK-DPEV--QPLQPSLEEDGDPADPLP 908
Cdd:NF033839 436 EKPKPEVKPQPEKpKPEVkpQPETPKPEVKPQPEKPKP 473
|
|
| DUF4045 |
pfam13254 |
Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. ... |
649-913 |
1.98e-03 |
|
Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. This domain family is found in bacteria and eukaryotes, and is typically between 384 and 430 amino acids in length.
Pssm-ID: 433066 [Multi-domain] Cd Length: 415 Bit Score: 42.08 E-value: 1.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 649 SPPGLEQT--------SINPLANFLTEEDTPMGAPELGFP-SLPWPPAS------VDDMMTPVGPGNPDELLVKedeqsp 713
Cdd:pfam13254 32 LPPGLSRQnsfasnrgSVAGPSGSLSPGLSPTKLSREGSPeSTSRPSSShseatiVRHSKDDERPSTPDEGFVK------ 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 714 PSTPWSDRNKLSTDGNPLGHTSPALPQSPiptqPSPPSI------SPTQASpspdvvevstgwnaaWdpvLEADL-KPgh 786
Cdd:pfam13254 106 PALPRHSRSSSALSNTGSEEDSPSLPTSP----PSPSKTmdpkrwSPTKSS---------------W---LESALnRP-- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 787 gELPSTVEVASPPLLP--MATVPGI--------WGRDSPLEPGTPT-FSSPELSSQHLKTLTMPGTLLLTVPTdlrSPGP 855
Cdd:pfam13254 162 -ESPKPKAQPSQPAQPawMKELNKIrqsrasvdLGRPNSFKEVTPVgLMRSPAPGGHSKSPSVSGISADSSPT---KEEP 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1720429990 856 SGQPQTPNLEGTQSPGLLPTPARETQTNSSKDPEVQPLQPSLEEDGDPADPLPARNAS 913
Cdd:pfam13254 238 SEEADTLSTDKEQSPAPTSASEPPPKTKELPKDSEEPAAPSKSAEASTEKKEPDTESS 295
|
|
| PLN03209 |
PLN03209 |
translocon at the inner envelope of chloroplast subunit 62; Provisional |
533-793 |
4.88e-03 |
|
translocon at the inner envelope of chloroplast subunit 62; Provisional
Pssm-ID: 178748 [Multi-domain] Cd Length: 576 Bit Score: 41.07 E-value: 4.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 533 IPNQLAPRPSP--ASSPKPVSISNAIDE-----EELDPPGPVFVDDfyydynfinfhEDLS-YGSFEEPHPDlvdnggwT 604
Cdd:PLN03209 323 IPSQRVPPKESdaADGPKPVPTKPVTPEapsppIEEEPPQPKAVVP-----------RPLSpYTAYEDLKPP-------T 384
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 605 APPHIRPTESPSDTPVPTAGALGAEAEDIQgswSPSPLLSEASYSPPGLEQTSINPLANFLTEED-TPMGAPELGFPSLP 683
Cdd:PLN03209 385 SPIPTPPSSSPASSKSVDAVAKPAEPDVVP---SPGSASNVPEVEPAQVEAKKTRPLSPYARYEDlKPPTSPSPTAPTGV 461
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 684 WPPASVDDMMTPVGPGNPDELLVKEDEQSPPSTPWSDRNKLSTDGNPLGHTSPALPQSPIPTQPSPPsiSPTQASPSPDV 763
Cdd:PLN03209 462 SPSVSSTSSVPAVPDTAPATAATDAAAPPPANMRPLSPYAVYDDLKPPTSPSPAAPVGKVAPSSTNE--VVKVGNSAPPT 539
|
250 260 270
....*....|....*....|....*....|....*.
gi 1720429990 764 VEVSTGWNAAWDP------VLEADLKPGHGELPSTV 793
Cdd:PLN03209 540 ALADEQHHAQPKPrplspyTMYEDLKPPTSPTPSPV 575
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
534-878 |
5.59e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 40.91 E-value: 5.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 534 PNQLAPRPSPASSPKPVSISNAIDEEELdPPGPvfvddfyydynfinfhEDLSYGSFEEPHPdlvdngGWTAPPHIRPTE 613
Cdd:pfam03154 248 PLQPMTQPPPPSQVSPQPLPQPSLHGQM-PPMP----------------HSLQTGPSHMQHP------VPPQPFPLTPQS 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 614 SPSDTPVPTAGALGAEAEdiQGSWSPSPLLSEASYSPPgleqtsinplanflteEDTPMGAPELGFPSLPWPPAS-VDDM 692
Cdd:pfam03154 305 SQSQVPPGPSPAAPGQSQ--QRIHTPPSQSQLQSQQPP----------------REQPLPPAPLSMPHIKPPPTTpIPQL 366
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 693 MTPVGPGNPDELLVKEDEQS----PPSTPWSDRNKLSTDGNPLGHTSPA--LPQS-PIPTQPS-PPSISPTQASPSPDVV 764
Cdd:pfam03154 367 PNPQSHKHPPHLSGPSPFQMnsnlPPPPALKPLSSLSTHHPPSAHPPPLqlMPQSqQLPPPPAqPPVLTQSQSLPPPAAS 446
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 765 EVSTGwnaAWDPVLEADLKPGHGELPStvevASPPLLPmatvpgiwgrdsplePGTPTFSSPELSSQHLKTLTMPGTLLL 844
Cdd:pfam03154 447 HPPTS---GLHQVPSQSPFPQHPFVPG----GPPPITP---------------PSGPPTSTSSAMPGIQPPSSASVSSSG 504
|
330 340 350
....*....|....*....|....*....|....
gi 1720429990 845 TVPTDLRSPGPSGQPQTPNLEGTQSPGLLPTPAR 878
Cdd:pfam03154 505 PVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPR 538
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
593-764 |
5.88e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 40.91 E-value: 5.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 593 PHPDLVDNGGWTAPPHI---RPTESPSDTPVPTA-GALGAEAEDIQGSWSPSPL--------LSEASYSPPGLEQTSINP 660
Cdd:pfam03154 362 PIPQLPNPQSHKHPPHLsgpSPFQMNSNLPPPPAlKPLSSLSTHHPPSAHPPPLqlmpqsqqLPPPPAQPPVLTQSQSLP 441
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 661 L--ANFLTEEDTPMGAPELGFPSLPWPPASVDDMMTPVGP---GNPDELLVKEDEQSPPSTPWSDRNKLSTDGNPLGHTS 735
Cdd:pfam03154 442 PpaASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPptsTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKE 521
|
170 180
....*....|....*....|....*....
gi 1720429990 736 PALPQSPIPTQPSPPSISPtqaSPSPDVV 764
Cdd:pfam03154 522 EALDEAEEPESPPPPPRSP---SPEPTVV 547
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
593-787 |
7.04e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 40.69 E-value: 7.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 593 PHPDLVDNGGWTAPPHIRP--TESPSDTPVPTAGALG----AEAEDIQGSWSPSPLLSE--ASYSPPGLEQTSINPLANF 664
Cdd:PHA03247 2806 DPPAAVLAPAAALPPAASPagPLPPPTSAQPTAPPPPpgppPPSLPLGGSVAPGGDVRRrpPSRSPAAKPAAPARPPVRR 2885
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429990 665 LTEEDTPMGAPELGFPSLPWPPASVDDMMTPvgPGNPDELLVKEDEQSPPSTPWSDRNKLSTDGNP-------------- 730
Cdd:PHA03247 2886 LARPAVSRSTESFALPPDQPERPPQPQAPPP--PQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPagagepsgavpqpw 2963
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1720429990 731 LGHTSPALPQSPIPTQPSPPSISPTQASPSPDVVEVSTGWNAAWDPVLEADLKPGHG 787
Cdd:PHA03247 2964 LGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPP 3020
|
|
| |
