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Conserved domains on  [gi|1720429843|ref|XP_030099804|]
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alpha-1,2-mannosyltransferase ALG9 isoform X6 [Mus musculus]

Protein Classification

glycosyltransferase family protein( domain architecture ID 229536)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PMT_2 super family cl21590
Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are ...
 51-336 3.67e-77

Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are not captured by pfam02366.


The actual alignment was detected with superfamily member pfam03901:

Pssm-ID: 473917  Cd Length: 414  Bit Score: 246.89  E-value: 3.67e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429843  51 RLTRAVCKKFGLHVSRMMLAFLVLSTGMFCSSSAFLPSSFCMYTTLIAMTGW--------YMDKTPIAVLGVAAGAILGW 122
Cdd:pfam03901  97 YLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLleygntsvSNYKYLKAVLLIAALAILGR 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429843 123 PFSAALGLPIAFDLL--ARKHRWKSFL--LWSLVALALFLVP--VVVIDSYYYGKLVVAPLNIVLYNVFtSHGPDLYVQN 196
Cdd:pfam03901 177 PTSALLWLPLVLYLLlrLRGKRLKLFLflAISLGLLVALLVLgaVILIDSYFYGRFVFTPLNFLKYNVL-SNGSSFYGTH 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429843 197 LGHPY-------------------------------WLTLAPMYIWFIIFFIQPHKEERFLFPVYPLICLCGAVALSALQ 245
Cdd:pfam03901 256 PWYFYfsnglpnilgpfllafilgplvlllrkvsrlSQLLAPILIWLFIYSLQPHKEERFLYPVYPLILLSAAIALTRLS 335

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429843 246 kcyhfvfQRYRLEHYTVTSNWLalgtvFLFGLLSFSRSVALFRGYHGPLDLYPEFYRIATDPTIHTVPEGRPVNVCVGKE 325
Cdd:pfam03901 336 -------RRSWKVRKKLSLLFL-----LLFFNVSLARLFGLVHQYGAPLAVYDVMSFLNETPRENRNPAGPPVNVCIGME 403

                         330
                  ....*....|.
gi 1720429843 326 WYRFPSSFLLP 336
Cdd:pfam03901 404 CYSTPSSFFLH 414
 
Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 51-336 3.67e-77

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 246.89  E-value: 3.67e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429843  51 RLTRAVCKKFGLHVSRMMLAFLVLSTGMFCSSSAFLPSSFCMYTTLIAMTGW--------YMDKTPIAVLGVAAGAILGW 122
Cdd:pfam03901  97 YLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLleygntsvSNYKYLKAVLLIAALAILGR 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429843 123 PFSAALGLPIAFDLL--ARKHRWKSFL--LWSLVALALFLVP--VVVIDSYYYGKLVVAPLNIVLYNVFtSHGPDLYVQN 196
Cdd:pfam03901 177 PTSALLWLPLVLYLLlrLRGKRLKLFLflAISLGLLVALLVLgaVILIDSYFYGRFVFTPLNFLKYNVL-SNGSSFYGTH 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429843 197 LGHPY-------------------------------WLTLAPMYIWFIIFFIQPHKEERFLFPVYPLICLCGAVALSALQ 245
Cdd:pfam03901 256 PWYFYfsnglpnilgpfllafilgplvlllrkvsrlSQLLAPILIWLFIYSLQPHKEERFLYPVYPLILLSAAIALTRLS 335

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429843 246 kcyhfvfQRYRLEHYTVTSNWLalgtvFLFGLLSFSRSVALFRGYHGPLDLYPEFYRIATDPTIHTVPEGRPVNVCVGKE 325
Cdd:pfam03901 336 -------RRSWKVRKKLSLLFL-----LLFFNVSLARLFGLVHQYGAPLAVYDVMSFLNETPRENRNPAGPPVNVCIGME 403

                         330
                  ....*....|.
gi 1720429843 326 WYRFPSSFLLP 336
Cdd:pfam03901 404 CYSTPSSFFLH 414
ArnT COG1807
PMT family glycosyltransferase ArnT/Agl22, involved in glycosylation of proteins and lipid IVA ...
 70-246 1.51e-04

PMT family glycosyltransferase ArnT/Agl22, involved in glycosylation of proteins and lipid IVA [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441412 [Multi-domain]  Cd Length: 309  Bit Score: 43.46  E-value: 1.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429843  70 AFLVLSTGMFCSSSAFLPSSFCMYTTLIAMTGWYM-----DKTPIAVLGVAAG-AIL--GWPFSAALGLPIAFDLLARKH 141
Cdd:COG1807   119 LLLLTSPLLLLFGRLATPDALLLLFWTLALYALLRalerrRLRWLLLAGLALGlGFLtkGPVALLLPGLALLLYLLLTRR 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429843 142 RWKSFLLWSLVALALFLvpvvvidsyyygkLVVAPLNIVLYNVftsHGPDLYVQNLGHPYWLTlapmyiwFIIFFIQPHK 221
Cdd:COG1807   199 WRRLRRLRLLLGLLLAL-------------LLALPWYIANDWA---TGPAFLEYFFGYENLVP-------LLFFSLSATK 255

                         170       180
                  ....*....|....*....|....*
gi 1720429843 222 EERFLFPVYPLICLCGAVALSALQK 246
Cdd:COG1807   256 LPRYLLPLLPALALLAAAGLARLRR 280
 
Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 51-336 3.67e-77

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 246.89  E-value: 3.67e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429843  51 RLTRAVCKKFGLHVSRMMLAFLVLSTGMFCSSSAFLPSSFCMYTTLIAMTGW--------YMDKTPIAVLGVAAGAILGW 122
Cdd:pfam03901  97 YLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLleygntsvSNYKYLKAVLLIAALAILGR 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429843 123 PFSAALGLPIAFDLL--ARKHRWKSFL--LWSLVALALFLVP--VVVIDSYYYGKLVVAPLNIVLYNVFtSHGPDLYVQN 196
Cdd:pfam03901 177 PTSALLWLPLVLYLLlrLRGKRLKLFLflAISLGLLVALLVLgaVILIDSYFYGRFVFTPLNFLKYNVL-SNGSSFYGTH 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429843 197 LGHPY-------------------------------WLTLAPMYIWFIIFFIQPHKEERFLFPVYPLICLCGAVALSALQ 245
Cdd:pfam03901 256 PWYFYfsnglpnilgpfllafilgplvlllrkvsrlSQLLAPILIWLFIYSLQPHKEERFLYPVYPLILLSAAIALTRLS 335

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429843 246 kcyhfvfQRYRLEHYTVTSNWLalgtvFLFGLLSFSRSVALFRGYHGPLDLYPEFYRIATDPTIHTVPEGRPVNVCVGKE 325
Cdd:pfam03901 336 -------RRSWKVRKKLSLLFL-----LLFFNVSLARLFGLVHQYGAPLAVYDVMSFLNETPRENRNPAGPPVNVCIGME 403

                         330
                  ....*....|.
gi 1720429843 326 WYRFPSSFLLP 336
Cdd:pfam03901 404 CYSTPSSFFLH 414
ArnT COG1807
PMT family glycosyltransferase ArnT/Agl22, involved in glycosylation of proteins and lipid IVA ...
 70-246 1.51e-04

PMT family glycosyltransferase ArnT/Agl22, involved in glycosylation of proteins and lipid IVA [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441412 [Multi-domain]  Cd Length: 309  Bit Score: 43.46  E-value: 1.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429843  70 AFLVLSTGMFCSSSAFLPSSFCMYTTLIAMTGWYM-----DKTPIAVLGVAAG-AIL--GWPFSAALGLPIAFDLLARKH 141
Cdd:COG1807   119 LLLLTSPLLLLFGRLATPDALLLLFWTLALYALLRalerrRLRWLLLAGLALGlGFLtkGPVALLLPGLALLLYLLLTRR 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720429843 142 RWKSFLLWSLVALALFLvpvvvidsyyygkLVVAPLNIVLYNVftsHGPDLYVQNLGHPYWLTlapmyiwFIIFFIQPHK 221
Cdd:COG1807   199 WRRLRRLRLLLGLLLAL-------------LLALPWYIANDWA---TGPAFLEYFFGYENLVP-------LLFFSLSATK 255

                         170       180
                  ....*....|....*....|....*
gi 1720429843 222 EERFLFPVYPLICLCGAVALSALQK 246
Cdd:COG1807   256 LPRYLLPLLPALALLAAAGLARLRR 280
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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