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Conserved domains on  [gi|1720426314|ref|XP_030099131|]
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protein CBFA2T3 isoform X8 [Mus musculus]

Protein Classification

TAFH and NHR2 domain-containing protein( domain architecture ID 10540113)

TAFH and NHR2 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TAFH pfam07531
NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the ...
 113-202 1.39e-43

NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the product of the nervy gene in Drosophila and the human mtg8b protein, which is hypothesized to be a transcription factor.


:

Pssm-ID: 462195  Cd Length: 90  Bit Score: 145.10  E-value: 1.39e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720426314 113 QLSKLKRFLTTLQQFGSDISPEIGERVRTLVLGLVNSTLTIEEFHAKLQEATNFPLRPFVIPFLKANLPLLQRELLHCAR 192
Cdd:pfam07531   1 NVKKCKNFLSTLIKLAGEQSPETGENVKELVQGLLNGKIEPEEFTSKLQEELNSSPQPYLVPFLKKSLPALRQELLNSAR 80

                          90
                  ....*....|
gi 1720426314 193 LAKQTPAQYL 202
Cdd:pfam07531  81 FIQQCPPQYL 90
NHR2 super family cl07409
NHR2 domain like; The NHR2 (Nervy homology 2) domain is found in the ETO protein where it ...
 321-342 4.48e-04

NHR2 domain like; The NHR2 (Nervy homology 2) domain is found in the ETO protein where it mediates oligomerization and protein-protein interactions. It forms an alpha-helical tetramer.


The actual alignment was detected with superfamily member pfam08788:

Pssm-ID: 430219  Cd Length: 67  Bit Score: 37.98  E-value: 4.48e-04
                          10        20
                  ....*....|....*....|..
gi 1720426314 321 QEEVIDHRLTEREWAEEWKHLN 342
Cdd:pfam08788   1 REEYIDTRLTDREWADEWRHLD 22
 
Name Accession Description Interval E-value
TAFH pfam07531
NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the ...
 113-202 1.39e-43

NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the product of the nervy gene in Drosophila and the human mtg8b protein, which is hypothesized to be a transcription factor.


Pssm-ID: 462195  Cd Length: 90  Bit Score: 145.10  E-value: 1.39e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720426314 113 QLSKLKRFLTTLQQFGSDISPEIGERVRTLVLGLVNSTLTIEEFHAKLQEATNFPLRPFVIPFLKANLPLLQRELLHCAR 192
Cdd:pfam07531   1 NVKKCKNFLSTLIKLAGEQSPETGENVKELVQGLLNGKIEPEEFTSKLQEELNSSPQPYLVPFLKKSLPALRQELLNSAR 80

                          90
                  ....*....|
gi 1720426314 193 LAKQTPAQYL 202
Cdd:pfam07531  81 FIQQCPPQYL 90
TAFH smart00549
TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila ...
 113-203 5.87e-40

TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila TAF110. Also known as nervy homology region 1 (NHR1).


Pssm-ID: 197785 [Multi-domain]  Cd Length: 92  Bit Score: 136.05  E-value: 5.87e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720426314  113 QLSKLKRFLTTLQQFGSDIS-PEIGERVRTLVLGLVNSTLTIEEFHAKLQEATNFPLRPFVIPFLKANLPLLQRELLHCA 191
Cdd:smart00549   1 NVSKCKRFLTTLIQLSNDISqPEVAERVRTLVLGLVNGTITAEEFTSRLQEALNSPLQPYLIPFLKNSLPLLRRELLHCA 80

                           90
                   ....*....|..
gi 1720426314  192 RLAKQTPAQYLA 203
Cdd:smart00549  81 RLIEQSPPQPLA 92
NHR2 pfam08788
NHR2 domain like; The NHR2 (Nervy homology 2) domain is found in the ETO protein where it ...
 321-342 4.48e-04

NHR2 domain like; The NHR2 (Nervy homology 2) domain is found in the ETO protein where it mediates oligomerization and protein-protein interactions. It forms an alpha-helical tetramer.


Pssm-ID: 430219  Cd Length: 67  Bit Score: 37.98  E-value: 4.48e-04
                          10        20
                  ....*....|....*....|..
gi 1720426314 321 QEEVIDHRLTEREWAEEWKHLN 342
Cdd:pfam08788   1 REEYIDTRLTDREWADEWRHLD 22
 
Name Accession Description Interval E-value
TAFH pfam07531
NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the ...
 113-202 1.39e-43

NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the product of the nervy gene in Drosophila and the human mtg8b protein, which is hypothesized to be a transcription factor.


Pssm-ID: 462195  Cd Length: 90  Bit Score: 145.10  E-value: 1.39e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720426314 113 QLSKLKRFLTTLQQFGSDISPEIGERVRTLVLGLVNSTLTIEEFHAKLQEATNFPLRPFVIPFLKANLPLLQRELLHCAR 192
Cdd:pfam07531   1 NVKKCKNFLSTLIKLAGEQSPETGENVKELVQGLLNGKIEPEEFTSKLQEELNSSPQPYLVPFLKKSLPALRQELLNSAR 80

                          90
                  ....*....|
gi 1720426314 193 LAKQTPAQYL 202
Cdd:pfam07531  81 FIQQCPPQYL 90
TAFH smart00549
TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila ...
 113-203 5.87e-40

TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila TAF110. Also known as nervy homology region 1 (NHR1).


Pssm-ID: 197785 [Multi-domain]  Cd Length: 92  Bit Score: 136.05  E-value: 5.87e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720426314  113 QLSKLKRFLTTLQQFGSDIS-PEIGERVRTLVLGLVNSTLTIEEFHAKLQEATNFPLRPFVIPFLKANLPLLQRELLHCA 191
Cdd:smart00549   1 NVSKCKRFLTTLIQLSNDISqPEVAERVRTLVLGLVNGTITAEEFTSRLQEALNSPLQPYLIPFLKNSLPLLRRELLHCA 80

                           90
                   ....*....|..
gi 1720426314  192 RLAKQTPAQYLA 203
Cdd:smart00549  81 RLIEQSPPQPLA 92
NHR2 pfam08788
NHR2 domain like; The NHR2 (Nervy homology 2) domain is found in the ETO protein where it ...
 321-342 4.48e-04

NHR2 domain like; The NHR2 (Nervy homology 2) domain is found in the ETO protein where it mediates oligomerization and protein-protein interactions. It forms an alpha-helical tetramer.


Pssm-ID: 430219  Cd Length: 67  Bit Score: 37.98  E-value: 4.48e-04
                          10        20
                  ....*....|....*....|..
gi 1720426314 321 QEEVIDHRLTEREWAEEWKHLN 342
Cdd:pfam08788   1 REEYIDTRLTDREWADEWRHLD 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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