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Conserved domains on  [gi|1663440916|ref|XP_029141781|]
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beta/gamma crystallin domain-containing protein 2 [Protobothrops mucrosquamatus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
beta-trefoil_Ricin-like super family cl49609
ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a ...
 692-827 6.88e-80

ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a carbohydrate-binding domain formed from presumed gene triplication. It shows a beta-trefoil fold characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ricin B-type lectin domain was originally found in Ricin, which is a legume lectin from the seeds of the castor bean plant, Ricinus communis. It is also found in many carbohydrate-recognition proteins like plant and bacterial AB-toxins, glycosidases, or proteases, which serve diverse functions such as inhibitory toxicity, enzymatic activity, and signal transduction. The ricin B-type lectin domain can be present in one or more copies and has been shown in some instances to bind simple sugars, such as galactose or lactose. The most characteristic, though not completely conserved, sequence feature is the presence of a Q-W pattern. Consequently, the ricin B-type lectin domain has also been referred as the (QxW)3 domain and the three homologous regions as the QxW repeats. A disulfide bond is also conserved in some QxW repeats.


The actual alignment was detected with superfamily member cd23465:

Pssm-ID: 483949  Cd Length: 136  Bit Score: 253.25  E-value: 6.88e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916 692 QRRIYFRIKNQELKTFLSVPDDVEDMKAGRVLVSEINDQNSCIWYYEEGLMKNQIAPNMSLQVIGAATKGTKVVLWSESR 771
Cdd:cd23465     1 QRRVYFRLRNRELGLYLAVPDGVEDMKAGRVVVTEQQEGMSHVWFYEDGLLKNQMAPTMSLQVIGPPDNGAKVVLWSETR 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1663440916 772 MPRQTWRIDSFGRICSQMFEDKVLDLKGGRTYDRDHAVLWESSEERPTQIWDIQVL 827
Cdd:cd23465    81 QPRQTWSIQPSGHILSQMFEGMILDVKGGRTYDRDHVVLWEVSEERPSQIWDMEVL 136
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 334-420 1.88e-33

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


:

Pssm-ID: 459639  Cd Length: 82  Bit Score: 123.37  E-value: 1.88e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916 334 KILIFERPHFQGRSWEVSRDIYNLRKSENNQDsmmstAGSLRIMGGCWVGYEKEGFRGHQYLLEEGEYCDWTDWGGYNEE 413
Cdd:pfam00030   1 KIVLYEKENFQGRSIELTDDCPSLQERGFNSR-----VNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDR 75


                  ....*..
gi 1663440916 414 LLSLRLI 420
Cdd:pfam00030  76 IGSLRPI 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 429-510 1.52e-27

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


:

Pssm-ID: 459639  Cd Length: 82  Bit Score: 106.42  E-value: 1.52e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916 429 IVLFEAMDFEdGPCVELSEALPDVELASYGIMTQSIHVLNGVWVAYEDKNFNGEQYILEKGVYRNCEDWGATSCQIASVQ 508
Cdd:pfam00030   2 IVLYEKENFQ-GRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLR 80


                  ..
gi 1663440916 509 PV 510
Cdd:pfam00030  81 PI 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 610-690 4.34e-22

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


:

Pssm-ID: 459639  Cd Length: 82  Bit Score: 91.02  E-value: 4.34e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916 610 SIFLHGLECFEGKEIELNSEVRSLKAEGFNNHVLSVRVKGGIWVLCEHSDFRGHQWVLECTEITNWLTYSGI-QQIGSLY 688
Cdd:pfam00030   1 KIVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPnDRIGSLR 80


                  ..
gi 1663440916 689 PI 690
Cdd:pfam00030  81 PI 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 240-320 1.11e-20

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


:

Pssm-ID: 459639  Cd Length: 82  Bit Score: 86.78  E-value: 1.11e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916 240 ITFFAEENGEGRKQRFTDSAEDLRTCGQPLNAASIIVHSGLWLVYSKPFFDDDPYVLEPGGYPNLQAWGAKDPSICSMHP 319
Cdd:pfam00030   2 IVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLRP 81


                  .
gi 1663440916 320 I 320
Cdd:pfam00030  82 I 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 523-602 4.21e-18

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


:

Pssm-ID: 459639  Cd Length: 82  Bit Score: 79.46  E-value: 4.21e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916 523 KIQLFTEPDFSGNSMTFQEDQATLPE---NLILHSCRVNGGSWILYDGHHFDGEQHVLSEGEYPTLSSMGCAfTTAICSL 599
Cdd:pfam00030   1 KIVLYEKENFQGRSIELTDDCPSLQErgfNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAP-NDRIGSL 79


                  ...
gi 1663440916 600 KKI 602
Cdd:pfam00030  80 RPI 82
Crystall super family cl02528
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 141-231 2.46e-14

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


The actual alignment was detected with superfamily member pfam00030:

Pssm-ID: 470604  Cd Length: 82  Bit Score: 68.67  E-value: 2.46e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916 141 KIILYSEAGFGGQKREIWNDVPDATSWELASTI-SIQVIRGGWLMYEKPRFHGRKCVLAEGnvEITNpWRMYCEEESerg 219
Cdd:pfam00030   1 KIVLYEKENFQGRSIELTDDCPSLQERGFNSRVnSIRVLSGAWVLYEHPNFRGRQYVLEPG--EYPD-WSDWGAPND--- 74

                          90
                  ....*....|..
gi 1663440916 220 napfRIGSLKRV 231
Cdd:pfam00030  75 ----RIGSLRPI 82
 
Name Accession Description Interval E-value
beta-trefoil_Ricin_CRYBG2 cd23465
ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin ...
 692-827 6.88e-80

ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin domain-containing protein 2 (CRYBG2) and similar proteins; CRYBG2, also called absent in melanoma 1-like protein (AIM1L), is a beta/gamma-crystallin family protein with a ricin B-type lectin domain at the C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.


Pssm-ID: 467343  Cd Length: 136  Bit Score: 253.25  E-value: 6.88e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916 692 QRRIYFRIKNQELKTFLSVPDDVEDMKAGRVLVSEINDQNSCIWYYEEGLMKNQIAPNMSLQVIGAATKGTKVVLWSESR 771
Cdd:cd23465     1 QRRVYFRLRNRELGLYLAVPDGVEDMKAGRVVVTEQQEGMSHVWFYEDGLLKNQMAPTMSLQVIGPPDNGAKVVLWSETR 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1663440916 772 MPRQTWRIDSFGRICSQMFEDKVLDLKGGRTYDRDHAVLWESSEERPTQIWDIQVL 827
Cdd:cd23465    81 QPRQTWSIQPSGHILSQMFEGMILDVKGGRTYDRDHVVLWEVSEERPSQIWDMEVL 136
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 334-420 1.88e-33

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 123.37  E-value: 1.88e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916 334 KILIFERPHFQGRSWEVSRDIYNLRKSENNQDsmmstAGSLRIMGGCWVGYEKEGFRGHQYLLEEGEYCDWTDWGGYNEE 413
Cdd:pfam00030   1 KIVLYEKENFQGRSIELTDDCPSLQERGFNSR-----VNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDR 75


                  ....*..
gi 1663440916 414 LLSLRLI 420
Cdd:pfam00030  76 IGSLRPI 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 429-510 1.52e-27

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 106.42  E-value: 1.52e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916 429 IVLFEAMDFEdGPCVELSEALPDVELASYGIMTQSIHVLNGVWVAYEDKNFNGEQYILEKGVYRNCEDWGATSCQIASVQ 508
Cdd:pfam00030   2 IVLYEKENFQ-GRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLR 80


                  ..
gi 1663440916 509 PV 510
Cdd:pfam00030  81 PI 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
 334-420 1.32e-26

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 103.74  E-value: 1.32e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916  334 KILIFERPHFQGRSWEVSRDIYNLRKSennqdSMMSTAGSLRIMGGCWVGYEKEGFRGHQYLLEEGEYCDWTDWGGYNEE 413
Cdd:smart00247   1 KITLYEDENFQGRSYELSDDCPSLQDY-----GSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQ 75


                   ....*..
gi 1663440916  414 LLSLRLI 420
Cdd:smart00247  76 ISSIRRI 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 610-690 4.34e-22

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 91.02  E-value: 4.34e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916 610 SIFLHGLECFEGKEIELNSEVRSLKAEGFNNHVLSVRVKGGIWVLCEHSDFRGHQWVLECTEITNWLTYSGI-QQIGSLY 688
Cdd:pfam00030   1 KIVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPnDRIGSLR 80


                  ..
gi 1663440916 689 PI 690
Cdd:pfam00030  81 PI 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 240-320 1.11e-20

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 86.78  E-value: 1.11e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916 240 ITFFAEENGEGRKQRFTDSAEDLRTCGQPLNAASIIVHSGLWLVYSKPFFDDDPYVLEPGGYPNLQAWGAKDPSICSMHP 319
Cdd:pfam00030   2 IVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLRP 81


                  .
gi 1663440916 320 I 320
Cdd:pfam00030  82 I 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
 429-510 2.37e-18

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 80.24  E-value: 2.37e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916  429 IVLFEAMDFEdGPCVELSEALPDveLASYGIM--TQSIHVLNGVWVAYEDKNFNGEQYILEKGVYRNCEDWGATSCQIAS 506
Cdd:smart00247   2 ITLYEDENFQ-GRSYELSDDCPS--LQDYGSRdnVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQISS 78


                   ....
gi 1663440916  507 VQPV 510
Cdd:smart00247  79 IRRI 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 523-602 4.21e-18

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 79.46  E-value: 4.21e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916 523 KIQLFTEPDFSGNSMTFQEDQATLPE---NLILHSCRVNGGSWILYDGHHFDGEQHVLSEGEYPTLSSMGCAfTTAICSL 599
Cdd:pfam00030   1 KIVLYEKENFQGRSIELTDDCPSLQErgfNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAP-NDRIGSL 79


                  ...
gi 1663440916 600 KKI 602
Cdd:pfam00030  80 RPI 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
 619-690 1.39e-17

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 77.93  E-value: 1.39e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1663440916  619 FEGKEIELNSEVRSLKAEGFNNHVLSVRVKGGIWVLCEHSDFRGHQWVLECTEITNWLTYSGIQ-QIGSLYPI 690
Cdd:smart00247  10 FQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNdQISSIRRI 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
 523-602 2.39e-15

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 71.77  E-value: 2.39e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916  523 KIQLFTEPDFSGNSMTFQEDQATLPENLI---LHSCRVNGGSWILYDGHHFDGEQHVLSEGEYPTLSSMGcAFTTAICSL 599
Cdd:smart00247   1 KITLYEDENFQGRSYELSDDCPSLQDYGSrdnVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWG-GFNDQISSI 79


                   ...
gi 1663440916  600 KKI 602
Cdd:smart00247  80 RRI 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
 240-320 3.39e-15

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 71.39  E-value: 3.39e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916  240 ITFFAEENGEGRKQRFTDSAEDLRTCGQPLNAASIIVHSGLWLVYSKPFFDDDPYVLEPGGYPNLQAWGAKDPSICSMHP 319
Cdd:smart00247   2 ITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQISSIRR 81


                   .
gi 1663440916  320 I 320
Cdd:smart00247  82 I 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 141-231 2.46e-14

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 68.67  E-value: 2.46e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916 141 KIILYSEAGFGGQKREIWNDVPDATSWELASTI-SIQVIRGGWLMYEKPRFHGRKCVLAEGnvEITNpWRMYCEEESerg 219
Cdd:pfam00030   1 KIVLYEKENFQGRSIELTDDCPSLQERGFNSRVnSIRVLSGAWVLYEHPNFRGRQYVLEPG--EYPD-WSDWGAPND--- 74

                          90
                  ....*....|..
gi 1663440916 220 napfRIGSLKRV 231
Cdd:pfam00030  75 ----RIGSLRPI 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
 141-231 4.12e-09

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 54.05  E-value: 4.12e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916  141 KIILYSEAGFGGQKREIWNDVPDATSWELASTI-SIQVIRGGWLMYEKPRFHGRKCVLAEGnvEITNPWRMyceeeserG 219
Cdd:smart00247   1 KITLYEDENFQGRSYELSDDCPSLQDYGSRDNVsSVRVESGCWVLYEQPNYRGRQYVLEPG--EYPDYQEW--------G 70

                           90
                   ....*....|..
gi 1663440916  220 NAPFRIGSLKRV 231
Cdd:smart00247  71 GFNDQISSIRRI 82
 
Name Accession Description Interval E-value
beta-trefoil_Ricin_CRYBG2 cd23465
ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin ...
 692-827 6.88e-80

ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin domain-containing protein 2 (CRYBG2) and similar proteins; CRYBG2, also called absent in melanoma 1-like protein (AIM1L), is a beta/gamma-crystallin family protein with a ricin B-type lectin domain at the C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.


Pssm-ID: 467343  Cd Length: 136  Bit Score: 253.25  E-value: 6.88e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916 692 QRRIYFRIKNQELKTFLSVPDDVEDMKAGRVLVSEINDQNSCIWYYEEGLMKNQIAPNMSLQVIGAATKGTKVVLWSESR 771
Cdd:cd23465     1 QRRVYFRLRNRELGLYLAVPDGVEDMKAGRVVVTEQQEGMSHVWFYEDGLLKNQMAPTMSLQVIGPPDNGAKVVLWSETR 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1663440916 772 MPRQTWRIDSFGRICSQMFEDKVLDLKGGRTYDRDHAVLWESSEERPTQIWDIQVL 827
Cdd:cd23465    81 QPRQTWSIQPSGHILSQMFEGMILDVKGGRTYDRDHVVLWEVSEERPSQIWDMEVL 136
beta-trefoil_Ricin_CRYBG cd23430
ricin B-type lectin domain, beta-trefoil fold, found in the beta/gamma crystallin ...
 695-826 7.96e-57

ricin B-type lectin domain, beta-trefoil fold, found in the beta/gamma crystallin domain-containing protein (CRYBG) family; The CRYBG family includes three members: CRYBG1, CRYBG2, and CRYBG3/vlAKAP. CRYBG1, also called absent in melanoma 1 protein (AIM1), may function as a suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton. CRYBG2 is also called absent in melanoma 1-like protein (AIM1L). CRYBG3/vlAKAP, also called very large A-kinase anchor protein, is an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). It binds to the dimeric RII-alpha regulatory subunit of PKA (PRKAR2A/PRKAR2B). CRYBG proteins belong to the beta/gamma-crystallin family. They all contain a ricin B-type lectin domain with a beta-trefoil fold at the C-terminus. The beta-trefoil fold is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.


Pssm-ID: 467308 [Multi-domain]  Cd Length: 133  Bit Score: 190.88  E-value: 7.96e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916 695 IYFRIKNQELKTFLSVPDDVEDMKAGRVLVSEINDQNSCIWYYEEGLMKNQIAPNMSLQVIGA-ATKGTKVVLWSESRMP 773
Cdd:cd23430     1 VYFRLRNKATGLFLSVNGNLEDLKLLRVQVMPDVGADDQIWYYQEGLIKCRIAEDCCLTVIGSlVTPGSKVGLWLEQNAD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1663440916 774 RQTWRIDSFGRICSQMFEDKVLDLKGGRTYDRDHAVLWESSEERPTQIWDIQV 826
Cdd:cd23430    81 RQFWSLKSDGRIYSKLKPNLVLDVKGGTQYDQNHVILNTPSEEKFTQVWEIMV 133
beta-trefoil_Ricin_vlAKAP cd23463
ricin B-type lectin domain, beta-trefoil fold, found in very large A-kinase anchor protein ...
 692-827 9.38e-36

ricin B-type lectin domain, beta-trefoil fold, found in very large A-kinase anchor protein (vlAKAP) and similar proteins; vlAKAP, also called beta/gamma crystallin domain-containing protein 3 (CRYBG3), is an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). It binds to the dimeric RII-alpha regulatory subunit of PKA (PRKAR2A/PRKAR2B). vlAKAP belongs to the beta/gamma-crystallin family. It contains a ricin B-type lectin domain at the C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.


Pssm-ID: 467341  Cd Length: 136  Bit Score: 131.79  E-value: 9.38e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916 692 QRRIYFRIKNQELKTFLSVPDDVEDMKAGRVLVSEINDQNSCIWYYEEGLMKNQiAPNMSLQVIGA-ATKGTKVVLWSES 770
Cdd:cd23463     1 QPRVYLRIKNRAQGLYLTTEGNLADPRATSVCVSQYNGKDTQIWYYCRGLLKSK-ANDACLDVIGGkDNPGSKVALWTEH 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1663440916 771 RMPRQTWRIDSFGRICSQMFEDKVLDLKGGRTYDRDHAVLWESSEERPTQIWDIQVL 827
Cdd:cd23463    80 GKTHQKWRINEDGTISSHLSDDLVLDLKGGNYYDKDHLIVNNPEEDQQTQKWDIELL 136
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 334-420 1.88e-33

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 123.37  E-value: 1.88e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916 334 KILIFERPHFQGRSWEVSRDIYNLRKSENNQDsmmstAGSLRIMGGCWVGYEKEGFRGHQYLLEEGEYCDWTDWGGYNEE 413
Cdd:pfam00030   1 KIVLYEKENFQGRSIELTDDCPSLQERGFNSR-----VNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDR 75


                  ....*..
gi 1663440916 414 LLSLRLI 420
Cdd:pfam00030  76 IGSLRPI 82
beta-trefoil_Ricin_CRYBG1 cd23464
ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin ...
 692-827 5.94e-29

ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin domain-containing protein 1 (CRYBG1) and similar proteins; CRYBG1, also called absent in melanoma 1 protein (AIM1), may function as a suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton. CRYBG1 belongs to the beta/gamma-crystallin family. It contains a ricin B-type lectin domain at the C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.


Pssm-ID: 467342  Cd Length: 137  Bit Score: 112.59  E-value: 5.94e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916 692 QRRIYFRIKNQELKTFLSVPDDVEDMKAGRVLVSEINDQNSCIWYYEEGLMKNQIAPNMSLQVIGA-ATKGTKVVLWSES 770
Cdd:cd23464     1 QKRVYFRLRNKETGCFMSTNGNLDDLKLLRIQVLEDTGSDDQIWVYQDGLIRCRMAEDCCLETVGNlVTAGSKLGLSLEQ 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1663440916 771 RMPRQTWRIDSFGRICSQMFEDKVLDLKGGRTYDRDHAVLWESSEERPTQIWDIQVL 827
Cdd:cd23464    81 GKDNQFWSITSDGRIYSKLKPDLVLDIKGGQQYDQNHVILNTFDEEKLTQRWEVEIL 137
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 429-510 1.52e-27

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 106.42  E-value: 1.52e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916 429 IVLFEAMDFEdGPCVELSEALPDVELASYGIMTQSIHVLNGVWVAYEDKNFNGEQYILEKGVYRNCEDWGATSCQIASVQ 508
Cdd:pfam00030   2 IVLYEKENFQ-GRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLR 80


                  ..
gi 1663440916 509 PV 510
Cdd:pfam00030  81 PI 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
 334-420 1.32e-26

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 103.74  E-value: 1.32e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916  334 KILIFERPHFQGRSWEVSRDIYNLRKSennqdSMMSTAGSLRIMGGCWVGYEKEGFRGHQYLLEEGEYCDWTDWGGYNEE 413
Cdd:smart00247   1 KITLYEDENFQGRSYELSDDCPSLQDY-----GSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQ 75


                   ....*..
gi 1663440916  414 LLSLRLI 420
Cdd:smart00247  76 ISSIRRI 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 610-690 4.34e-22

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 91.02  E-value: 4.34e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916 610 SIFLHGLECFEGKEIELNSEVRSLKAEGFNNHVLSVRVKGGIWVLCEHSDFRGHQWVLECTEITNWLTYSGI-QQIGSLY 688
Cdd:pfam00030   1 KIVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPnDRIGSLR 80


                  ..
gi 1663440916 689 PI 690
Cdd:pfam00030  81 PI 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 240-320 1.11e-20

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 86.78  E-value: 1.11e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916 240 ITFFAEENGEGRKQRFTDSAEDLRTCGQPLNAASIIVHSGLWLVYSKPFFDDDPYVLEPGGYPNLQAWGAKDPSICSMHP 319
Cdd:pfam00030   2 IVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLRP 81


                  .
gi 1663440916 320 I 320
Cdd:pfam00030  82 I 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
 429-510 2.37e-18

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 80.24  E-value: 2.37e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916  429 IVLFEAMDFEdGPCVELSEALPDveLASYGIM--TQSIHVLNGVWVAYEDKNFNGEQYILEKGVYRNCEDWGATSCQIAS 506
Cdd:smart00247   2 ITLYEDENFQ-GRSYELSDDCPS--LQDYGSRdnVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQISS 78


                   ....
gi 1663440916  507 VQPV 510
Cdd:smart00247  79 IRRI 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 523-602 4.21e-18

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 79.46  E-value: 4.21e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916 523 KIQLFTEPDFSGNSMTFQEDQATLPE---NLILHSCRVNGGSWILYDGHHFDGEQHVLSEGEYPTLSSMGCAfTTAICSL 599
Cdd:pfam00030   1 KIVLYEKENFQGRSIELTDDCPSLQErgfNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAP-NDRIGSL 79


                  ...
gi 1663440916 600 KKI 602
Cdd:pfam00030  80 RPI 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
 619-690 1.39e-17

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 77.93  E-value: 1.39e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1663440916  619 FEGKEIELNSEVRSLKAEGFNNHVLSVRVKGGIWVLCEHSDFRGHQWVLECTEITNWLTYSGIQ-QIGSLYPI 690
Cdd:smart00247  10 FQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNdQISSIRRI 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
 523-602 2.39e-15

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 71.77  E-value: 2.39e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916  523 KIQLFTEPDFSGNSMTFQEDQATLPENLI---LHSCRVNGGSWILYDGHHFDGEQHVLSEGEYPTLSSMGcAFTTAICSL 599
Cdd:smart00247   1 KITLYEDENFQGRSYELSDDCPSLQDYGSrdnVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWG-GFNDQISSI 79


                   ...
gi 1663440916  600 KKI 602
Cdd:smart00247  80 RRI 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
 240-320 3.39e-15

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 71.39  E-value: 3.39e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916  240 ITFFAEENGEGRKQRFTDSAEDLRTCGQPLNAASIIVHSGLWLVYSKPFFDDDPYVLEPGGYPNLQAWGAKDPSICSMHP 319
Cdd:smart00247   2 ITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQISSIRR 81


                   .
gi 1663440916  320 I 320
Cdd:smart00247  82 I 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 141-231 2.46e-14

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 68.67  E-value: 2.46e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916 141 KIILYSEAGFGGQKREIWNDVPDATSWELASTI-SIQVIRGGWLMYEKPRFHGRKCVLAEGnvEITNpWRMYCEEESerg 219
Cdd:pfam00030   1 KIVLYEKENFQGRSIELTDDCPSLQERGFNSRVnSIRVLSGAWVLYEHPNFRGRQYVLEPG--EYPD-WSDWGAPND--- 74

                          90
                  ....*....|..
gi 1663440916 220 napfRIGSLKRV 231
Cdd:pfam00030  75 ----RIGSLRPI 82
beta-trefoil_Ricin_SCDase cd23456
ricin B-type lectin domain, beta-trefoil fold, found in Shewanella algae sphingolipid ceramide ...
 696-801 9.62e-10

ricin B-type lectin domain, beta-trefoil fold, found in Shewanella algae sphingolipid ceramide N-deacylase (SCDase) and similar proteins; SCDase (EC 3.5.1.69) is an enzyme which hydrolyzes the N-acyl linkage between fatty acid and sphingosine in ceramide of various glycosphingolipids and sphingomyelin. Shewanella algae SCDase contains two ricin B-type lectin domains at its C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.


Pssm-ID: 467334 [Multi-domain]  Cd Length: 122  Bit Score: 56.98  E-value: 9.62e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916 696 YFRIKNQELKTFLSVPDDVedMKAGRVLVSEINDQNSCIWYYEE-GLMKNQIAPNMSLQVIGAATKGTKVVLWSESRMPR 774
Cdd:cd23456     2 YFQLKSQASGLCLDVSGGA--TNGANVVVYDCNNSNSQKWYYDAtGRLHSKANPGKCLDAGGENSNGANVVLWACNDSAN 79

                          90       100
                  ....*....|....*....|....*..
gi 1663440916 775 QTWRIDSfGRICSQMFEDKVLDLKGGR 801
Cdd:cd23456    80 QRWDFDG-NFIRSRNNTNLALDAYGSQ 105
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
 141-231 4.12e-09

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 54.05  E-value: 4.12e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916  141 KIILYSEAGFGGQKREIWNDVPDATSWELASTI-SIQVIRGGWLMYEKPRFHGRKCVLAEGnvEITNPWRMyceeeserG 219
Cdd:smart00247   1 KITLYEDENFQGRSYELSDDCPSLQDYGSRDNVsSVRVESGCWVLYEQPNYRGRQYVLEPG--EYPDYQEW--------G 70

                           90
                   ....*....|..
gi 1663440916  220 NAPFRIGSLKRV 231
Cdd:smart00247  71 GFNDQISSIRRI 82
beta-trefoil_Ricin_MOA-like cd23416
ricin B-type lectin domain, beta-trefoil fold, found in Marasmius oreades agglutinin (MOA) and ...
 750-825 1.67e-06

ricin B-type lectin domain, beta-trefoil fold, found in Marasmius oreades agglutinin (MOA) and similar proteins; The family includes Marasmius oreades agglutinin (MOA) and Polyporus squamosus Ricin B-related lectin (PSL). MOA is a lectin isolated from fruiting bodies of the mushroom M. oreades. It specifically binds non-reducing terminal Galalpha(1,3)Gal carbohydrates, such as that which occurs in the xenotransplantation epitope Galalpha(1,3)Galbeta(1,4)GlcNAc and the branched blood group B determinant Galalpha(1,3)[Fucalpha(1,2)]Gal. Polyporus squamosus Ricin B-related lectin (PSL) is a lectin specific for glycans terminating with the sequence Neu5Acalpha2-6Galbeta. Like MOA, PSL is a calcium-dependent cysteine protease. Both MOA and PSL contain an N-terminal ricin B-type lectin domain and a C-terminal agglutinin domain. The ricin B-type lectin domain is a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.


Pssm-ID: 467295 [Multi-domain]  Cd Length: 145  Bit Score: 48.50  E-value: 1.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916 750 MSLQViGAATKGTKVVLWSESRMPRQTWRIDSFGRICSQMFEDK----VLDLKGGRTYDRDHAVLWESSEERPTQIWDIQ 825
Cdd:cd23416    66 LDLAG-GSSANGTAIVGWQSTNNPNQQWVIKPANGGTYYKIQNKgtgtFLDLYGGDSANGTKIVGWTGHWGNPNQLWLFE 144
beta-trefoil_Ricin-like cd00161
ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a ...
 696-822 1.98e-06

ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a carbohydrate-binding domain formed from presumed gene triplication. It shows a beta-trefoil fold characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ricin B-type lectin domain was originally found in Ricin, which is a legume lectin from the seeds of the castor bean plant, Ricinus communis. It is also found in many carbohydrate-recognition proteins like plant and bacterial AB-toxins, glycosidases, or proteases, which serve diverse functions such as inhibitory toxicity, enzymatic activity, and signal transduction. The ricin B-type lectin domain can be present in one or more copies and has been shown in some instances to bind simple sugars, such as galactose or lactose. The most characteristic, though not completely conserved, sequence feature is the presence of a Q-W pattern. Consequently, the ricin B-type lectin domain has also been referred as the (QxW)3 domain and the three homologous regions as the QxW repeats. A disulfide bond is also conserved in some QxW repeats.


Pssm-ID: 467293 [Multi-domain]  Cd Length: 134  Bit Score: 47.75  E-value: 1.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916 696 YFRIKNQELKTFLSVPDDveDMKAG-RVLVSEINDQNSCIWYYEE-----GLMKNQiAPNMSLQVIGAATK-GTKVVLWS 768
Cdd:cd00161     2 TYRIVNAASGKCLDVAGG--STANGaPVQQWTCNGGANQQWTLTPvgdgyYTIRNV-ASGKCLDVAGGSTAnGANVQQWT 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1663440916 769 ESRMPRQTWRI----DSFGRICSQMfEDKVLDLKGGRTYDRDHAVLWESSeERPTQIW 822
Cdd:cd00161    79 CNGGDNQQWRLepvgDGYYRIVNKH-SGKCLDVSGGSTANGANVQQWTCN-GGANQQW 134
beta-trefoil_Ricin_SCDase_rpt1 cd23499
first ricin B-type lectin domain, beta-trefoil fold, found in Shewanella algae sphingolipid ...
 696-823 7.40e-04

first ricin B-type lectin domain, beta-trefoil fold, found in Shewanella algae sphingolipid ceramide N-deacylase (SCDase) and similar proteins; SCDase (EC 3.5.1.69) is an enzyme which hydrolyzes the N-acyl linkage between fatty acid and sphingosine in ceramide of various glycosphingolipids and sphingomyelin. Shewanella algae SCDase contains two ricin B-type lectin domains at its C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket. The model corresponds to the first lectin domain.


Pssm-ID: 467377 [Multi-domain]  Cd Length: 131  Bit Score: 40.51  E-value: 7.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663440916 696 YFRIKNQELKTFLSVPDDVEDMKAGRVLV-----SEINDQNsciWYY--EEGLMKNQIAPNMSLQVIGAATKGTKVVLWS 768
Cdd:cd23499     2 FVRIVNRASGKCLDIPGNDNDVVNGANVIlwdcaDKSADQR---WIYdaASGMLRNKANPSYCLDNRGQAYNGGEVVLWQ 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1663440916 769 ESRMPRQTWRIDSfGRICSQMFEDKVLDlKGGRTYDrDHAVLWEsSEERPTQIWD 823
Cdd:cd23499    79 CEDSDNLRWTYDN-GVLRSKHNPNIVLD-AYGRDNN-SQVGQWE-YHGGANQQWE 129
beta-trefoil_Ricin_XLN-like cd23418
ricin B-type lectin domain, beta-trefoil fold, found in Streptomyces olivaceoviridis endo-1, ...
 756-822 7.78e-04

ricin B-type lectin domain, beta-trefoil fold, found in Streptomyces olivaceoviridis endo-1,4-beta-xylanase and similar proteins; The family includes Streptomyces olivaceoviridis endo-1,4-beta-xylanase (XLN, EC 3.2.1.8), Streptomyces avermitilis beta-L-arabinopyranosidase (EC 3.2.1.185), and Streptomyces coelicolor extracellular exo-alpha-L-arabinofuranosidase (ABF, EC 3.2.1.55). XLN, also called xylanase, or 1,4-beta-D-xylan xylanohydrolase, belongs to the glycosyl hydrolase 10 (cellulase F) family. It contributes to hydrolyze hemicellulose, the major component of plant cell walls. XLN contains a (beta/alpha)8-barrel as a catalytic domain, a family 13 carbohydrate binding module (CBM13) as a xylan binding domain (XBD) and a Gly/Pro-rich linker between them. Beta-L-arabinopyranosidase belongs to the glycosyl hydrolase 27 (GH27) family. It has a GH27 catalytic domain, an antiparallel beta-domain containing Greek key motifs, another antiparallel beta-domain forming a jellyroll structure, and a CBM13 module. ScAraf62A, also called ABF, or arabinosidase, or arabinoxylan arabinofuranohydrolase, belongs to the glycosyl hydrolase 62 (GH62) family. It is involved in the degradation of xylan and is a key enzyme in the complete degradation of the plant cell wall. It has a specific arabinofuranose-debranching activity on xylan from gramineae. It acts synergistically with xylanases and binds specifically to xylan. ScAraf62A comprises a CBM13 module at its N-terminus and a catalytic domain at its C-terminus. This model corresponds to the CBM13 module, which is a ricin B-type lectin domain with a beta-trefoil fold, characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may contain a potential sugar-binding pocket.


Pssm-ID: 467297 [Multi-domain]  Cd Length: 130  Bit Score: 40.41  E-value: 7.78e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1663440916 756 GAATKGTKVVLWSESRMPRQTWRIDSFGRICSQMfEDKVLDLKGGRTYDRDHAVLWeSSEERPTQIW 822
Cdd:cd23418    64 GGTTNGTPVVIWPCNGGANQKWRFNSDGTIRNVN-SGLCLDVAGGGTANGTRLILW-SCNGGSNQRW 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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