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Conserved domains on  [gi|1622969675|ref|XP_028697802|]
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ankyrin repeat and SOCS box protein 9 isoform X3 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
36-217 2.28e-30

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 114.67  E-value: 2.28e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675  36 DWSPMHEAAIYGHQLSLRNLISQ---VNGVTTDWHTPLFNACVSGSRDCVNLLLQHGASV-QPESDLASPIHEAARRGHA 111
Cdd:COG0666    87 GNTLLHAAARNGDLEIVKLLLEAgadVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675 112 ECVDSLIAYGSNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLHAVARTASEELACLLMDFGADTQ 190
Cdd:COG0666   167 EIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNaKDNDGKTALDLAAENGNLEIVKLLLEAGADLN 246

                         170       180
                  ....*....|....*....|....*..
gi 1622969675 191 AKNAEGKRPVELVPPDSPLARLFLERE 217
Cdd:COG0666   247 AKDKDGLTALLLAAAAGAALIVKLLLL 273
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 217-258 1.18e-19

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239698  Cd Length: 42  Bit Score: 79.45  E-value: 1.18e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1622969675 217 EGPPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLHL 258
Cdd:cd03728     1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
36-217 2.28e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 114.67  E-value: 2.28e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675  36 DWSPMHEAAIYGHQLSLRNLISQ---VNGVTTDWHTPLFNACVSGSRDCVNLLLQHGASV-QPESDLASPIHEAARRGHA 111
Cdd:COG0666    87 GNTLLHAAARNGDLEIVKLLLEAgadVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675 112 ECVDSLIAYGSNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLHAVARTASEELACLLMDFGADTQ 190
Cdd:COG0666   167 EIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNaKDNDGKTALDLAAENGNLEIVKLLLEAGADLN 246

                         170       180
                  ....*....|....*....|....*..
gi 1622969675 191 AKNAEGKRPVELVPPDSPLARLFLERE 217
Cdd:COG0666   247 AKDKDGLTALLLAAAAGAALIVKLLLL 273
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 217-258 1.18e-19

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 79.45  E-value: 1.18e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1622969675 217 EGPPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLHL 258
Cdd:cd03728     1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
102-193 1.92e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.06  E-value: 1.92e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675 102 IHEAARRGHAECVDSLIAYGSNIDHKISHLGTPLYLACENQQRACVKKLLESgADVNQGKGQDSPLHAVARTASEELACL 181
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|..
gi 1622969675 182 LMDFGADTQAKN 193
Cdd:pfam12796  80 LLEKGADINVKD 91
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 38-200 8.34e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 70.86  E-value: 8.34e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675  38 SPMHEAAIYGHQL-SLRNLISQ---VNGVTTDWHTPLFNA-CVSGSRDCVNLLLQHGASVQPESDL-ASPIHEAARRGHA 111
Cdd:PHA02876  309 TPLYLMAKNGYDTeNIRTLIMLgadVNAADRLYITPLHQAsTLDRNKDIVITLLELGANVNARDYCdKTPIHYAAVRNNV 388

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675 112 ECVDSLIAYGSNIDHKISHLGTPLYLA-CENQQRACVKKLLESGADVN-QGKGQDSPLH-AVARTASEELACLLMDFGAD 188
Cdd:PHA02876  389 VIINTLLDYGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGANVNsKNKDLSTPLHyACKKNCKLDVIEMLLDNGAD 468

                         170
                  ....*....|..
gi 1622969675 189 TQAKNAEGKRPV 200
Cdd:PHA02876  469 VNAINIQNQYPL 480
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 218-256 2.47e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 54.48  E-value: 2.47e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1622969675 218 GPPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLL 256
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 220-257 5.20e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 45.09  E-value: 5.20e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1622969675  220 PSLMQLCRLRIRKCFGiqqhhKITKLVLPEDLKQFLLH 257
Cdd:smart00969   1 RSLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLY 33
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 133-191 2.05e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 45.46  E-value: 2.05e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622969675 133 TPLYLACENQQRACVKKLLESGADVN---------QGKGQD------SPLHAVARTASEELACLLMDFGADTQA 191
Cdd:TIGR00870 130 TALHLAAHRQNYEIVKLLLERGASVParacgdffvKSQGVDsfyhgeSPLNAAACLGSPSIVALLSEDPADILT 203
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 133-158 4.80e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 4.80e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622969675  133 TPLYLACENQQRACVKKLLESGADVN 158
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 40-185 1.27e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 39.61  E-value: 1.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675  40 MHEAAIYGH-QLSL------RNLISQVngVTTDWH---TPLFNACVSGSRDCVNLLLQHGASVQpeSDLASPIheAARRG 109
Cdd:cd22192    55 LHVAALYDNlEAAVvlmeaaPELVNEP--MTSDLYqgeTALHIAVVNQNLNLVRELIARGADVV--SPRATGT--FFRPG 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675 110 haecVDSLIAYGsniDHKIShlgtplYLACENQQRAcVKKLLESGADVnqgKGQDS----PLHAVARTASEELACLLMDF 185
Cdd:cd22192   129 ----PKNLIYYG---EHPLS------FAACVGNEEI-VRLLIEHGADI---RAQDSlgntVLHILVLQPNKTFACQMYDL 191
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
36-217 2.28e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 114.67  E-value: 2.28e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675  36 DWSPMHEAAIYGHQLSLRNLISQ---VNGVTTDWHTPLFNACVSGSRDCVNLLLQHGASV-QPESDLASPIHEAARRGHA 111
Cdd:COG0666    87 GNTLLHAAARNGDLEIVKLLLEAgadVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675 112 ECVDSLIAYGSNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLHAVARTASEELACLLMDFGADTQ 190
Cdd:COG0666   167 EIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNaKDNDGKTALDLAAENGNLEIVKLLLEAGADLN 246

                         170       180
                  ....*....|....*....|....*..
gi 1622969675 191 AKNAEGKRPVELVPPDSPLARLFLERE 217
Cdd:COG0666   247 AKDKDGLTALLLAAAAGAALIVKLLLL 273
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
22-258 5.86e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 113.51  E-value: 5.86e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675  22 IRLLSNPLMSDAVSDWSPMHEAAIYGHQLSLRNLISQ---VNGVTTDWHTPLFNACVSGSRDCVNLLLQHGASV-QPESD 97
Cdd:COG0666    40 LLLALLALALADALGALLLLAAALAGDLLVALLLLAAgadINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVnARDKD 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675  98 LASPIHEAARRGHAECVDSLIAYGSNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLHAVARTASE 176
Cdd:COG0666   120 GETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNaRDNDGETPLHLAAENGHL 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675 177 ELACLLMDFGADTQAKNAEGKRPVEL--VPPDSPLARLFLEREGPPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQF 254
Cdd:COG0666   200 EIVKLLLEAGADVNAKDNDGKTALDLaaENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLA 279


                  ....
gi 1622969675 255 LLHL 258
Cdd:COG0666   280 AALL 283
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
50-199 7.03e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 91.94  E-value: 7.03e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675  50 LSLRNLISQVNGVTTDWHTPLFNACVSGSRDCVNLLLQHGASV-QPESDLASPIHEAARRGHAECVDSLIAYGSNIDHKI 128
Cdd:COG0666    38 LLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADInAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARD 117

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622969675 129 SHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRP 199
Cdd:COG0666   118 KDGETPLHLAAYNGNLEIVKLLLEAGADVNaQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETP 189
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 217-258 1.18e-19

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 79.45  E-value: 1.18e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1622969675 217 EGPPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLHL 258
Cdd:cd03728     1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 217-257 1.71e-14

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 65.59  E-value: 1.71e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1622969675 217 EGPPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLH 257
Cdd:cd03716     1 STPRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLY 41
Ank_2 pfam12796
Ankyrin repeats (3 copies);
102-193 1.92e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.06  E-value: 1.92e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675 102 IHEAARRGHAECVDSLIAYGSNIDHKISHLGTPLYLACENQQRACVKKLLESgADVNQGKGQDSPLHAVARTASEELACL 181
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|..
gi 1622969675 182 LMDFGADTQAKN 193
Cdd:pfam12796  80 LLEKGADINVKD 91
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 38-200 8.34e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 70.86  E-value: 8.34e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675  38 SPMHEAAIYGHQL-SLRNLISQ---VNGVTTDWHTPLFNA-CVSGSRDCVNLLLQHGASVQPESDL-ASPIHEAARRGHA 111
Cdd:PHA02876  309 TPLYLMAKNGYDTeNIRTLIMLgadVNAADRLYITPLHQAsTLDRNKDIVITLLELGANVNARDYCdKTPIHYAAVRNNV 388

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675 112 ECVDSLIAYGSNIDHKISHLGTPLYLA-CENQQRACVKKLLESGADVN-QGKGQDSPLH-AVARTASEELACLLMDFGAD 188
Cdd:PHA02876  389 VIINTLLDYGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGANVNsKNKDLSTPLHyACKKNCKLDVIEMLLDNGAD 468

                         170
                  ....*....|..
gi 1622969675 189 TQAKNAEGKRPV 200
Cdd:PHA02876  469 VNAINIQNQYPL 480
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 219-257 4.58e-13

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 61.72  E-value: 4.58e-13
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1622969675 219 PPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLH 257
Cdd:cd03587     2 PRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLY 40
Ank_2 pfam12796
Ankyrin repeats (3 copies);
40-127 5.01e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.21  E-value: 5.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675  40 MHEAAIYGHQLSLRNLI---SQVNGVTTDWHTPLFNACVSGSRDCVNLLLQHgASVQPESDLASPIHEAARRGHAECVDS 116
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLengADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|.
gi 1622969675 117 LIAYGSNIDHK 127
Cdd:pfam12796  80 LLEKGADINVK 90
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 57-203 2.21e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 66.06  E-value: 2.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675  57 SQVNGVTTDW-HTPLFNACVSGSRDCVNLLLQHGASVQ-PESDLASPIHEAARRGHAECVDSLIAYGSNIDHKISHLGTP 134
Cdd:PHA02878  158 ADINMKDRHKgNTALHYATENKDQRLTELLLSYGANVNiPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTP 237

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622969675 135 LYLA---CENQQraCVKKLLESGADVNQGKG--QDSPLHAVARtaSEELACLLMDFGADTQAKNAEGKRPVELV 203
Cdd:PHA02878  238 LHISvgyCKDYD--ILKLLLEHGVDVNAKSYilGLTALHSSIK--SERKLKLLLEYGADINSLNSYKLTPLSSA 307
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 218-256 2.47e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 54.48  E-value: 2.47e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1622969675 218 GPPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLL 256
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 68-194 2.65e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 53.90  E-value: 2.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675  68 TPLFNACV--SGSRDCVNLLLQHGASVQP-ESDLASPIHEAARRGHAEC------------------VDSLIAYGSNIDH 126
Cdd:PHA03100  108 TPLLYAISkkSNSYSIVEYLLDNGANVNIkNSDGENLLHLYLESNKIDLkilkllidkgvdinaknrVNYLLSYGVPINI 187

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675 127 KISHLGTPLYLACENQQRACVKKLLESGADVN--QGKGqDSPLHAVARTASEELACLLMDFGADTQAKNA 194
Cdd:PHA03100  188 KDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNlvNKYG-DTPLHIAILNNNKEIFKLLLNNGPSIKTIIE 256
Ank_2 pfam12796
Ankyrin repeats (3 copies);
37-92 3.39e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 50.11  E-value: 3.39e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622969675  37 WSPMHEAAIYGHQLSLRNLISQVNG-VTTDWHTPLFNACVSGSRDCVNLLLQHGASV 92
Cdd:pfam12796  31 RTALHLAAKNGHLEIVKLLLEHADVnLKDNGRTALHYAARSGHLEIVKLLLEKGADI 87
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 17-189 2.31e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 51.15  E-value: 2.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675  17 RDSPDIRLLsnpLMSDAVSDW------SPMHEAAIYGHQLSLRNLI---SQVNGVT-TDWHTPLFNACVSGSRDCVNLLL 86
Cdd:PHA02875   46 RDSEAIKLL---MKHGAIPDVkypdieSELHDAVEEGDVKAVEELLdlgKFADDVFyKDGMTPLHLATILKKLDIMKLLI 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675  87 QHGASVQ-PESDLASPIHEAARRGHAECVDSLIAYGSNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQ-GKGQD 164
Cdd:PHA02875  123 ARGADPDiPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYfGKNGC 202

                         170       180
                  ....*....|....*....|....*.
gi 1622969675 165 SPLHAVA-RTASEELACLLMDFGADT 189
Cdd:PHA02875  203 VAALCYAiENNKIDIVRLFIKRGADC 228
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 57-200 2.35e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 51.12  E-value: 2.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675  57 SQVNGVTTDWHTPLFNACVSGSRDCVNLLLQHG--ASVQPESDLASP----------------------IHEAARRGHAE 112
Cdd:PHA02874   59 ADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGvdTSILPIPCIEKDmiktildcgidvnikdaelktfLHYAIKKGDLE 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675 113 CVDSLIAYGSNIDHKISHLGTPLYLACENQQRACVKKLLESGA--DVNQGKGqDSPLHAVARTASEELACLLMDFGADTQ 190
Cdd:PHA02874  139 SIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAyaNVKDNNG-ESPLHNAAEYGDYACIKLLIDHGNHIM 217

                         170
                  ....*....|
gi 1622969675 191 AKNAEGKRPV 200
Cdd:PHA02874  218 NKCKNGFTPL 227
PHA03095 PHA03095
ankyrin-like protein; Provisional
 82-200 4.92e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.02  E-value: 4.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675  82 VNLLLQHGASVQPESDLAS-PIHEAARRGHAEC---VDSLIAYGSNIDHKISHLGTPLYLACENQQRACVKKLL-ESGAD 156
Cdd:PHA03095   30 VRRLLAAGADVNFRGEYGKtPLHLYLHYSSEKVkdiVRLLLEAGADVNAPERCGFTPLHLYLYNATTLDVIKLLiKAGAD 109

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1622969675 157 VN-QGKGQDSPLHAVARTAS--EELACLLMDFGADTQAKNAEGKRPV 200
Cdd:PHA03095  110 VNaKDKVGRTPLHVYLSGFNinPKVIRLLLRKGADVNALDLYGMTPL 156
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 220-257 5.20e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 45.09  E-value: 5.20e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1622969675  220 PSLMQLCRLRIRKCFGiqqhhKITKLVLPEDLKQFLLH 257
Cdd:smart00969   1 RSLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLY 33
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 219-257 9.30e-07

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 44.72  E-value: 9.30e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1622969675 219 PPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLH 257
Cdd:cd03720     3 PRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLH 41
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 219-255 1.36e-06

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 44.10  E-value: 1.36e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1622969675 219 PPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFL 255
Cdd:cd03724     3 PSSLCQLCRLCIRNYIGRSRLHLIPQLQLPTLLKNFL 39
PHA03095 PHA03095
ankyrin-like protein; Provisional
 111-199 1.42e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 48.87  E-value: 1.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675 111 AECVDSLIAYGSNIDHKISHLGTPL--YLACENQQRA-CVKKLLESGADVN-QGKGQDSPLHAVARTASEE-LACLLMDF 185
Cdd:PHA03095   27 VEEVRRLLAAGADVNFRGEYGKTPLhlYLHYSSEKVKdIVRLLLEAGADVNaPERCGFTPLHLYLYNATTLdVIKLLIKA 106

                          90
                  ....*....|....
gi 1622969675 186 GADTQAKNAEGKRP 199
Cdd:PHA03095  107 GADVNAKDKVGRTP 120
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 69-201 2.43e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 48.04  E-value: 2.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675  69 PLFNACVSGSRDCVNLLLQHGASVQ-PESDLASPIHEAARRGHAECVDSLIAYGSNIDHKISHLGTPLYLACENQQRACv 147
Cdd:PHA02874  160 PIHIAIKHNFFDIIKLLLEKGAYANvKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAI- 238

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622969675 148 kKLLESGADVN-QGKGQDSPLH-AVARTASEELACLLMDFGADTQAKNAEGKRPVE 201
Cdd:PHA02874  239 -ELLINNASINdQDIDGSTPLHhAINPPCDIDIIDILLYHKADISIKDNKGENPID 293
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 59-191 5.16e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 47.37  E-value: 5.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675  59 VNGVTTDWHTPLFNACVSGS-RDCVNLLLQHGASVQPES-DLASPIHEAARRGH-AECVDSLIAYGSNIDHKISHLGTPL 135
Cdd:PHA02876  266 VNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKNiKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPL 345

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622969675 136 YLACE-NQQRACVKKLLESGADVNQGKGQD-SPLHAVARTASEELACLLMDFGADTQA 191
Cdd:PHA02876  346 HQASTlDRNKDIVITLLELGANVNARDYCDkTPIHYAAVRNNVVIINTLLDYGADIEA 403
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 219-258 6.06e-06

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 42.46  E-value: 6.06e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1622969675 219 PPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLHL 258
Cdd:cd03729     3 PLSLQQLCRINLRKALGTRALEKIAKLNIPNRIIDYLSYN 42
Ank_4 pfam13637
Ankyrin repeats (many copies);
66-118 8.30e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.26  E-value: 8.30e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622969675  66 WHTPLFNACVSGSRDCVNLLLQHGASV--QPESDLaSPIHEAARRGHAECVDSLI 118
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADInaVDGNGE-TALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
100-151 8.46e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.26  E-value: 8.46e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622969675 100 SPIHEAARRGHAECVDSLIAYGSNIDHKISHLGTPLYLACENQQRACVKKLL 151
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 217-257 8.80e-06

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 41.77  E-value: 8.80e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1622969675 217 EGPPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLH 257
Cdd:cd03721     1 EPPRPLAHLCRLKVRTLIGINRIKLIDTLPLPPRLIRYLNH 41
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 45-202 9.49e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 46.11  E-value: 9.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675  45 IYGHQLSL-RNLISQ----VNGVTTDWHTPLFNACVSGSRDCVNLLLQHGASV-QPESDLASPIHEAARRGHAECVDSLI 118
Cdd:PHA02874    9 IYSGDIEAiEKIIKNkgncINISVDETTTPLIDAIRSGDAKIVELFIKHGADInHINTKIPHPLLTAIKIGAHDIIKLLI 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675 119 AYGsnIDHKIshlgtpLYLACENQQraCVKKLLESGADVN-QGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGK 197
Cdd:PHA02874   89 DNG--VDTSI------LPIPCIEKD--MIKTILDCGIDVNiKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGC 158


                  ....*
gi 1622969675 198 RPVEL 202
Cdd:PHA02874  159 YPIHI 163
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 217-256 1.01e-05

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 41.43  E-value: 1.01e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1622969675 217 EGPPSLMQLCRLRIRKCFGIqqhHKITKLVLPEDLKQFLL 256
Cdd:cd03717     1 TSVRSLQHLCRFVIRQCTRR---DLIDQLPLPRRLKDYLK 37
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 219-256 1.59e-05

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 41.27  E-value: 1.59e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1622969675 219 PPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLL 256
Cdd:cd03723     3 PRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLL 40
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 84-203 1.67e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 45.82  E-value: 1.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675  84 LLLQHGASVQPESDLA-SPIHEAARRGHAECVDSLIAYGS--------------------NID---------HKISHLGT 133
Cdd:PHA02876  163 MLLEGGADVNAKDIYCiTPIHYAAERGNAKMVNLLLSYGAdvniialddlsvlecavdskNIDtikaiidnrSNINKNDL 242

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622969675 134 PLYLACENQQRACVKKLLESGADVNQ-GKGQDSPLHAVARTAS-EELACLLMDFGADTQAKNAEGKRPVELV 203
Cdd:PHA02876  243 SLLKAIRNEDLETSLLLYDAGFSVNSiDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKNIKGETPLYLM 314
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 133-191 2.05e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 45.46  E-value: 2.05e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622969675 133 TPLYLACENQQRACVKKLLESGADVN---------QGKGQD------SPLHAVARTASEELACLLMDFGADTQA 191
Cdd:TIGR00870 130 TALHLAAHRQNYEIVKLLLERGASVParacgdffvKSQGVDsfyhgeSPLNAAACLGSPSIVALLSEDPADILT 203
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 70-202 2.29e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 44.98  E-value: 2.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675  70 LFNACVSGSRDCVNLLLQHGasVQPESDLA---SPIHEAARRGHAECVDSLIAYGSNIDHKISHLGTPLYLACENQQRAC 146
Cdd:PHA02875    6 LCDAILFGELDIARRLLDIG--INPNFEIYdgiSPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKA 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622969675 147 VKKLLESGA---DVNQGKGqDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVEL 202
Cdd:PHA02875   84 VEELLDLGKfadDVFYKDG-MTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHL 141
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 219-257 2.31e-05

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 40.75  E-value: 2.31e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1622969675 219 PPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLH 257
Cdd:cd03718     3 PLPLMDLCRRRVRVALGRDRLEEIEQLPLPPSLKNYLLY 41
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 68-131 5.33e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 43.89  E-value: 5.33e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622969675  68 TPLFNACVSGSRDCVNLLLQHGASVQPESDLA-SPIHEAARRGHAECVDSLIAYGSNIDHKISHL 131
Cdd:PHA03100  194 TPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGdTPLHIAILNNNKEIFKLLLNNGPSIKTIIETL 258
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 38-157 8.26e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 43.70  E-value: 8.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675  38 SPMHEAAIYGHQ---LSLRNLISQVNGVTTDWHTPLFNACVSGSRDCVNLLLQHGASVQPES--DLaspIHEAARRGHAE 112
Cdd:PLN03192  560 TPLHIAASKGYEdcvLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASISDPHAagDL---LCTAAKRNDLT 636

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1622969675 113 CVDSLIAYGSNIDHKISHLGTPLYLACENQQRACVKKLLESGADV 157
Cdd:PLN03192  637 AMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADV 681
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 219-255 3.34e-04

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 37.63  E-value: 3.34e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1622969675 219 PPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFL 255
Cdd:cd03743     3 PLPLMDLCRRSARQALGRHRLHHIQSLPLPQTLKNYL 39
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 68-148 3.57e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 41.12  E-value: 3.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675  68 TPLFNACVSGSRDCVNLLLQHGASVQPESDLA--SPIHEAARRGHAECVDSLIAYGSNIDHKISHLGTPLYLA---CENQ 142
Cdd:PHA02884   72 NPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAkiTPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIELAlmiCNNF 151


                  ....*.
gi 1622969675 143 QRACVK 148
Cdd:PHA02884  152 LAFMIC 157
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 133-158 4.80e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 4.80e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622969675  133 TPLYLACENQQRACVKKLLESGADVN 158
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 216-256 4.95e-04

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 36.89  E-value: 4.95e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1622969675  216 REGPPSLMQLCRLRIRKCFGIQQhhkITKLVLPEDLKQFLL 256
Cdd:smart00253   4 PSNVPSLQHLCRFTIRRCTRTDQ---IKTLPLPPKLKDYLS 41
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 38-158 8.80e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 39.97  E-value: 8.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675  38 SPMHEAAIYGHQLSLRNLI---SQVNGVTTDWHTPLFNACVSGSRDCVNLLLQHGASVQPESDLA-SPIHEAARRGHAEC 113
Cdd:PHA02875  104 TPLHLATILKKLDIMKLLIargADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGcTPLIIAMAKGDIAI 183

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1622969675 114 VDSLIAYGSNIDHkISHLG--TPLYLACENQQRACVKKLLESGADVN 158
Cdd:PHA02875  184 CKMLLDSGANIDY-FGKNGcvAALCYAIENNKIDIVRLFIKRGADCN 229
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 40-185 1.27e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 39.61  E-value: 1.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675  40 MHEAAIYGH-QLSL------RNLISQVngVTTDWH---TPLFNACVSGSRDCVNLLLQHGASVQpeSDLASPIheAARRG 109
Cdd:cd22192    55 LHVAALYDNlEAAVvlmeaaPELVNEP--MTSDLYqgeTALHIAVVNQNLNLVRELIARGADVV--SPRATGT--FFRPG 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675 110 haecVDSLIAYGsniDHKIShlgtplYLACENQQRAcVKKLLESGADVnqgKGQDS----PLHAVARTASEELACLLMDF 185
Cdd:cd22192   129 ----PKNLIYYG---EHPLS------FAACVGNEEI-VRLLIEHGADI---RAQDSlgntVLHILVLQPNKTFACQMYDL 191
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 217-257 2.61e-03

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 35.19  E-value: 2.61e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1622969675 217 EGPPSLMQLCRLRIRKCFGIQQHHK---ITKLVLPEDLKQFLLH 257
Cdd:cd03731     1 ENPRPLKHLCRLKIRKLMGLQKLQQpssMKKLPLPPALKRYILY 44
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 98-209 2.80e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 38.73  E-value: 2.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675  98 LASPIHEAARRGHAECVDSLIAYGSNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLHAVARTASE 176
Cdd:PTZ00322   82 LTVELCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTlLDKDGKTPLELAEENGFR 161

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1622969675 177 ELACLLM-------DFGADTQAKNAEGKRPVELvppDSPL 209
Cdd:PTZ00322  162 EVVQLLSrhsqchfELGANAKPDSFTGKPPSLE---DSPI 198
SOCS_ASB7 cd03726
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a ...
 219-257 3.02e-03

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239696  Cd Length: 45  Bit Score: 34.82  E-value: 3.02e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1622969675 219 PPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLH 257
Cdd:cd03726     3 PRTLQDLCRIKIRHCIGLQNLKLLDELPIAKVMKDYLKH 41
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
 219-257 3.08e-03

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 34.57  E-value: 3.08e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1622969675 219 PPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLH 257
Cdd:cd03744     3 PLPLMDLCRRSVRLALGRERLSEIHTLPLPASLKNYLLY 41
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 124-199 3.30e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 38.49  E-value: 3.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675 124 IDHKISHLGTPLYLACENQQRACVKKLLESGADVNQ-GKGQDSPLHAVAR-----TASEELACLLMDFGADTQAKNAEGK 197
Cdd:PHA03100   28 NDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSsTKNNSTPLHYLSNikynlTDVKEIVKLLLEYGANVNAPDNNGI 107


                  ..
gi 1622969675 198 RP 199
Cdd:PHA03100  108 TP 109
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 65-92 3.31e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 3.31e-03
                           10        20
                   ....*....|....*....|....*...
gi 1622969675   65 DWHTPLFNACVSGSRDCVNLLLQHGASV 92
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 217-257 3.48e-03

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 34.82  E-value: 3.48e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1622969675 217 EGPPSLMQLCRLRIRKCFG---IQQHHKITKLVLPEDLKQFLLH 257
Cdd:cd03730     1 TNPRSLKHLCRLKIRACMGrlrLRCPVFMSFLPLPNRLKAYILY 44
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 66-200 5.61e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 37.68  E-value: 5.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675  66 WHTPLFNACVSGSRDCVN-LLLQHGASVQPESDLA-SPIHEAARRGH-------AECVDSLI--AYGSNIdhkisHLG-T 133
Cdd:cd22192    17 SESPLLLAAKENDVQAIKkLLKCPSCDLFQRGALGeTALHVAALYDNleaavvlMEAAPELVnePMTSDL-----YQGeT 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675 134 PLYLACENQQRACVKKLLESGADVNQG--------KGQDS-------PLHAVARTASEELACLLMDFGADTQAKNAEGKR 198
Cdd:cd22192    92 ALHIAVVNQNLNLVRELIARGADVVSPratgtffrPGPKNliyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNT 171


                  ..
gi 1622969675 199 PV 200
Cdd:cd22192   172 VL 173
PHA03095 PHA03095
ankyrin-like protein; Provisional
 135-202 5.81e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 37.70  E-value: 5.81e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622969675 135 LYLACENQQRAC---VKKLLESGADVNQGKGQDS-PLHAVARTASEELA---CLLMDFGADTQAKNAEGKRPVEL 202
Cdd:PHA03095   15 LYDYLLNASNVTveeVRRLLAAGADVNFRGEYGKtPLHLYLHYSSEKVKdivRLLLEAGADVNAPERCGFTPLHL 89
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 100-125 6.39e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 33.33  E-value: 6.39e-03
                           10        20
                   ....*....|....*....|....*.
gi 1622969675  100 SPIHEAARRGHAECVDSLIAYGSNID 125
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
Ank_4 pfam13637
Ankyrin repeats (many copies);
133-182 7.57e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 33.79  E-value: 7.57e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622969675 133 TPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLHAVARTASEELACLL 182
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINaVDGNGETALHFAASNGNVEVLKLL 53
Ank_4 pfam13637
Ankyrin repeats (many copies);
37-86 8.19e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 33.79  E-value: 8.19e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622969675  37 WSPMHEAAIYGHQLSLRNLIS---QVNGVTTDWHTPLFNACVSGSRDCVNLLL 86
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEkgaDINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 133-158 8.35e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 33.00  E-value: 8.35e-03
                          10        20
                  ....*....|....*....|....*.
gi 1622969675 133 TPLYLACENQQRACVKKLLESGADVN 158
Cdd:pfam13606   4 TPLHLAARNGRLEIVKLLLENGADIN 29
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
83-199 8.57e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 36.86  E-value: 8.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969675  83 NLLLQHGASVQPESDLASPIHEAARRGHAECVDSLIAYGSNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQ-GK 161
Cdd:COG0666     6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAkDD 85

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1622969675 162 GQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRP 199
Cdd:COG0666    86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETP 123
Ank_5 pfam13857
Ankyrin repeats (many copies);
85-138 9.18e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 33.86  E-value: 9.18e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622969675  85 LLQHG--ASVQPESDLASPIHEAARRGHAECVDSLIAYGSNIDHKISHLGTPLYLA 138
Cdd:pfam13857   1 LLEHGpiDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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