NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1622147285|ref|XP_028558210|]
View 

protein ABHD4 isoform X3 [Podarcis muralis]

Protein Classification

alpha/beta hydrolase domain-containing protein( domain architecture ID 1005082)

alpha/beta hydrolase (abhydrolase) domain-containing protein

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  19508187|12369917

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PLN02894 super family cl30398
hydrolase, alpha/beta fold family protein
 32-315 8.17e-63

hydrolase, alpha/beta fold family protein


The actual alignment was detected with superfamily member PLN02894:

Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 204.37  E-value: 8.17e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285  32 IWTVSLSPERGKgrTPLVMVHGFGGGIGLWILNLDSLSQRRPLHAFDLLGFGRSSRPPFP-RDAQGAEEEFVNSIEAWRR 110
Cdd:PLN02894   94 INTVTFDSKEDA--PTLVMVHGYGASQGFFFRNFDALASRFRVIAIDQLGWGGSSRPDFTcKSTEETEAWFIDSFEEWRK 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285 111 EMGIPSMILLGHSLGGFLAASYSLQYPERVKHLILVDPWGFPMRPSDPAQ--IRAPPTWVKAVATVLGRSN--PLAVLRA 186
Cdd:PLN02894  172 AKNLSNFILLGHSFGGYVAAKYALKHPEHVQHLILVGPAGFSSESDDKSEwlTKFRATWKGAVLNHLWESNftPQKIIRG 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285 187 AGPWGPGLVQRFRpdfKQKFADFFDDDTISE--------YIYHCNAQTPSGEAGFKAMSEAFGWARRPMLERIHLVRrdL 258
Cdd:PLN02894  252 LGPWGPNLVRRYT---TARFGAHSTGDILSEeesklltdYVYHTLAAKASGELCLKYIFSFGAFARKPLLESASEWK--V 326

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622147285 259 PITLIYGANSWIDTSTGEKV--KILRPGSYVcdmAIPGASHHVYADQPHAFNAAVAEIC 315
Cdd:PLN02894  327 PTTFIYGRHDWMNYEGAVEArkRMKVPCEII---RVPQGGHFVFLDNPSGFHSAVLYAC 382
 
Name Accession Description Interval E-value
PLN02894 PLN02894
hydrolase, alpha/beta fold family protein
 32-315 8.17e-63

hydrolase, alpha/beta fold family protein


Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 204.37  E-value: 8.17e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285  32 IWTVSLSPERGKgrTPLVMVHGFGGGIGLWILNLDSLSQRRPLHAFDLLGFGRSSRPPFP-RDAQGAEEEFVNSIEAWRR 110
Cdd:PLN02894   94 INTVTFDSKEDA--PTLVMVHGYGASQGFFFRNFDALASRFRVIAIDQLGWGGSSRPDFTcKSTEETEAWFIDSFEEWRK 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285 111 EMGIPSMILLGHSLGGFLAASYSLQYPERVKHLILVDPWGFPMRPSDPAQ--IRAPPTWVKAVATVLGRSN--PLAVLRA 186
Cdd:PLN02894  172 AKNLSNFILLGHSFGGYVAAKYALKHPEHVQHLILVGPAGFSSESDDKSEwlTKFRATWKGAVLNHLWESNftPQKIIRG 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285 187 AGPWGPGLVQRFRpdfKQKFADFFDDDTISE--------YIYHCNAQTPSGEAGFKAMSEAFGWARRPMLERIHLVRrdL 258
Cdd:PLN02894  252 LGPWGPNLVRRYT---TARFGAHSTGDILSEeesklltdYVYHTLAAKASGELCLKYIFSFGAFARKPLLESASEWK--V 326

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622147285 259 PITLIYGANSWIDTSTGEKV--KILRPGSYVcdmAIPGASHHVYADQPHAFNAAVAEIC 315
Cdd:PLN02894  327 PTTFIYGRHDWMNYEGAVEArkRMKVPCEII---RVPQGGHFVFLDNPSGFHSAVLYAC 382
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 40-318 5.76e-27

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 105.47  E-value: 5.76e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285  40 ERGKGRTPLVMVHGFGGGIGLWILNLDSLSQRRPLHAFDLLGFGRSSRPPFPRDAqgaeEEFVNSIEAWRREMGIPSMIL 119
Cdd:COG0596    18 EAGPDGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGGYTL----DDLADDLAALLDALGLERVVL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285 120 LGHSLGGFLAASYSLQYPERVKHLILVdpwgfpmrpsdpaqirapptwvkavatvlgrsnplavlraagpwgpglvqrfr 199
Cdd:COG0596    94 VGHSMGGMVALELAARHPERVAGLVLV----------------------------------------------------- 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285 200 pdfkqkfadffdDDTISEYIYHCNAQTPSGEAGFKAMSEAFGWARRPMLERIhlvrrDLPITLIYGANS-WIDTSTGEKV 278
Cdd:COG0596   121 ------------DEVLAALAEPLRRPGLAPEALAALLRALARTDLRERLARI-----TVPTLVIWGEKDpIVPPALARRL 183

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1622147285 279 KILRPGSYVCDmaIPGASHHVYADQPHAFNAAVAEICDSV 318
Cdd:COG0596   184 AELLPNAELVV--LPGAGHFPPLEQPEAFAAALRDFLARL 221
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 46-304 4.47e-22

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 92.95  E-value: 4.47e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285  46 TPLVMVHGFGGGIGLWILNLDSLS-QRRPLHAFDLLGFGRSSRPPFPRDaqGAEEEFVNSIEAWRREMGIPSMILLGHSL 124
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALArDGFRVIALDLRGFGKSSRPKAQDD--YRTDDLAEDLEYILEALGLEKVNLVGHSM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285 125 GGFLAASYSLQYPERVKHLILVDP--WGFPMRPSDPAQIRAPPTWVKAVATVLGRsNPLAVLRA---AGPWGPGLVQRFR 199
Cdd:pfam00561  79 GGLIALAYAAKYPDRVKALVLLGAldPPHELDEADRFILALFPGFFDGFVADFAP-NPLGRLVAkllALLLLRLRLLKAL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285 200 PDFKQKFADFFDDDTISEYIYHcnaqtpsgeAGFKAmseafGWARRPMLERIHlvRRDLPITLIYGANSWIDT-STGEKV 278
Cdd:pfam00561 158 PLLNKRFPSGDYALAKSLVTGA---------LLFIE-----TWSTELRAKFLG--RLDEPTLIIWGDQDPLVPpQALEKL 221

                         250       260
                  ....*....|....*....|....*.
gi 1622147285 279 KILRPGSYVCdmAIPGASHHVYADQP 304
Cdd:pfam00561 222 AQLFPNARLV--VIPDAGHFAFLEGP 245
Esterase_713_like-1 cd12808
Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated ...
 70-188 6.46e-06

Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; This family contains uncharacterized proteins similar to a novel bacterial esterase (Alcaligenes esterase 713) with the alpha/beta hydrolase fold but does not contain the GXSXXG pentapeptide around the active site serine residue as commonly seen in other enzymes of this class. Esterase 713 shows negligible sequence homology to other esterase and lipase enzymes. It is active as a dimer and cleaves esters on halogenated cyclic compounds though its natural substrate is unknown.


Pssm-ID: 214007  Cd Length: 309  Bit Score: 46.85  E-value: 6.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285  70 QRRPLHAFDllGFGRSSRPPFPRDAQGAEEEFVNSIEawrremGIPSMILLGHSLGGFLAASYSLQYPERVKHLILVDPW 149
Cdd:cd12808   151 QQFPLAAFD--AFAKQFVPRWLGTDALTLAAYDALLD------RVGPCIVVAHSQGGGFAFEAARARPDLVRAVVALEPS 222

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622147285 150 GFPMRPSDPA------------QIRAPPTWVKAVATVlgrSNPLAVLRAAG 188
Cdd:cd12808   223 GAPDPAEAAPladvphllvwgdYIDADPRWPRYRATV---DAYAAALRAAG 270
 
Name Accession Description Interval E-value
PLN02894 PLN02894
hydrolase, alpha/beta fold family protein
 32-315 8.17e-63

hydrolase, alpha/beta fold family protein


Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 204.37  E-value: 8.17e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285  32 IWTVSLSPERGKgrTPLVMVHGFGGGIGLWILNLDSLSQRRPLHAFDLLGFGRSSRPPFP-RDAQGAEEEFVNSIEAWRR 110
Cdd:PLN02894   94 INTVTFDSKEDA--PTLVMVHGYGASQGFFFRNFDALASRFRVIAIDQLGWGGSSRPDFTcKSTEETEAWFIDSFEEWRK 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285 111 EMGIPSMILLGHSLGGFLAASYSLQYPERVKHLILVDPWGFPMRPSDPAQ--IRAPPTWVKAVATVLGRSN--PLAVLRA 186
Cdd:PLN02894  172 AKNLSNFILLGHSFGGYVAAKYALKHPEHVQHLILVGPAGFSSESDDKSEwlTKFRATWKGAVLNHLWESNftPQKIIRG 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285 187 AGPWGPGLVQRFRpdfKQKFADFFDDDTISE--------YIYHCNAQTPSGEAGFKAMSEAFGWARRPMLERIHLVRrdL 258
Cdd:PLN02894  252 LGPWGPNLVRRYT---TARFGAHSTGDILSEeesklltdYVYHTLAAKASGELCLKYIFSFGAFARKPLLESASEWK--V 326

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622147285 259 PITLIYGANSWIDTSTGEKV--KILRPGSYVcdmAIPGASHHVYADQPHAFNAAVAEIC 315
Cdd:PLN02894  327 PTTFIYGRHDWMNYEGAVEArkRMKVPCEII---RVPQGGHFVFLDNPSGFHSAVLYAC 382
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 40-318 5.76e-27

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 105.47  E-value: 5.76e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285  40 ERGKGRTPLVMVHGFGGGIGLWILNLDSLSQRRPLHAFDLLGFGRSSRPPFPRDAqgaeEEFVNSIEAWRREMGIPSMIL 119
Cdd:COG0596    18 EAGPDGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGGYTL----DDLADDLAALLDALGLERVVL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285 120 LGHSLGGFLAASYSLQYPERVKHLILVdpwgfpmrpsdpaqirapptwvkavatvlgrsnplavlraagpwgpglvqrfr 199
Cdd:COG0596    94 VGHSMGGMVALELAARHPERVAGLVLV----------------------------------------------------- 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285 200 pdfkqkfadffdDDTISEYIYHCNAQTPSGEAGFKAMSEAFGWARRPMLERIhlvrrDLPITLIYGANS-WIDTSTGEKV 278
Cdd:COG0596   121 ------------DEVLAALAEPLRRPGLAPEALAALLRALARTDLRERLARI-----TVPTLVIWGEKDpIVPPALARRL 183

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1622147285 279 KILRPGSYVCDmaIPGASHHVYADQPHAFNAAVAEICDSV 318
Cdd:COG0596   184 AELLPNAELVV--LPGAGHFPPLEQPEAFAAALRDFLARL 221
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 46-304 4.47e-22

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 92.95  E-value: 4.47e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285  46 TPLVMVHGFGGGIGLWILNLDSLS-QRRPLHAFDLLGFGRSSRPPFPRDaqGAEEEFVNSIEAWRREMGIPSMILLGHSL 124
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALArDGFRVIALDLRGFGKSSRPKAQDD--YRTDDLAEDLEYILEALGLEKVNLVGHSM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285 125 GGFLAASYSLQYPERVKHLILVDP--WGFPMRPSDPAQIRAPPTWVKAVATVLGRsNPLAVLRA---AGPWGPGLVQRFR 199
Cdd:pfam00561  79 GGLIALAYAAKYPDRVKALVLLGAldPPHELDEADRFILALFPGFFDGFVADFAP-NPLGRLVAkllALLLLRLRLLKAL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285 200 PDFKQKFADFFDDDTISEYIYHcnaqtpsgeAGFKAmseafGWARRPMLERIHlvRRDLPITLIYGANSWIDT-STGEKV 278
Cdd:pfam00561 158 PLLNKRFPSGDYALAKSLVTGA---------LLFIE-----TWSTELRAKFLG--RLDEPTLIIWGDQDPLVPpQALEKL 221

                         250       260
                  ....*....|....*....|....*.
gi 1622147285 279 KILRPGSYVCdmAIPGASHHVYADQP 304
Cdd:pfam00561 222 AQLFPNARLV--VIPDAGHFAFLEGP 245
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 40-151 3.09e-19

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 86.92  E-value: 3.09e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285  40 ERGKG-RTPLVMVHGFGGGIGLWILNLDSLSQRRPLHAFDLLGFGRSSrppfPRDAQGAEEEFVNSIEAWRREMGIPSMI 118
Cdd:PRK14875  125 RLGEGdGTPVVLIHGFGGDLNNWLFNHAALAAGRPVIALDLPGHGASS----KAVGAGSLDELAAAVLAFLDALGIERAH 200

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1622147285 119 LLGHSLGGFLAASYSLQYPERVKHLILVDPWGF 151
Cdd:PRK14875  201 LVGHSMGGAVALRLAARAPQRVASLTLIAPAGL 233
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
21-149 1.39e-15

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 74.27  E-value: 1.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285  21 ARYISLPNHAKIWTVSLSPErGKGRTPLVMVHGFGGGIGLWILNLDSLSQRR-PLHAFDLLGFGRSSRPpfpRDAQGAEE 99
Cdd:COG2267     5 LVTLPTRDGLRLRGRRWRPA-GSPRGTVVLVHGLGEHSGRYAELAEALAAAGyAVLAFDLRGHGRSDGP---RGHVDSFD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622147285 100 EFVNSIEAW----RREMGIPsMILLGHSLGGFLAASYSLQYPERVKHLILVDPW 149
Cdd:COG2267    81 DYVDDLRAAldalRARPGLP-VVLLGHSMGGLIALLYAARYPDRVAGLVLLAPA 133
PLN02578 PLN02578
hydrolase
 40-313 1.04e-14

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 73.72  E-value: 1.04e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285  40 ERGKGrTPLVMVHGFGGGIGLWILNLDSLSQRRPLHAFDLLGFGRSSRPPFPRDAQGAEEEfvnsIEAWRREMGIPSMIL 119
Cdd:PLN02578   82 VQGEG-LPIVLIHGFGASAFHWRYNIPELAKKYKVYALDLLGFGWSDKALIEYDAMVWRDQ----VADFVKEVVKEPAVL 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285 120 LGHSLGGFLAASYSLQYPERVKHLILVDPWGFPMRPSDPaqiraPPTWVKAVATVLGRSnplaVLRAAGPWGPGLV---- 195
Cdd:PLN02578  157 VGNSLGGFTALSTAVGYPELVAGVALLNSAGQFGSESRE-----KEEAIVVEETVLTRF----VVKPLKEWFQRVVlgfl 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285 196 -------QRFRPDFKQKFADFFD-DDTISEYIYHCNAQTPSGEAGFKAMSEAFGWARRPMLERIhLVRRDLPITLIYG-A 266
Cdd:PLN02578  228 fwqakqpSRIESVLKSVYKDKSNvDDYLVESITEPAADPNAGEVYYRLMSRFLFNQSRYTLDSL-LSKLSCPLLLLWGdL 306

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1622147285 267 NSWIDTSTGEKVKILRPGSYVCDMAipgASHHVYADQPHAFNAAVAE 313
Cdd:PLN02578  307 DPWVGPAKAEKIKAFYPDTTLVNLQ---AGHCPHDEVPEQVNKALLE 350
PLN03087 PLN03087
BODYGUARD 1 domain containing hydrolase; Provisional
 38-152 9.55e-11

BODYGUARD 1 domain containing hydrolase; Provisional


Pssm-ID: 215567  Cd Length: 481  Bit Score: 62.52  E-value: 9.55e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285  38 SPERGKGRTPLVMVHGFGGGIGLWILNL-----DSLSQRRPLHAFDLLGFGRSsrpPFPRDAQGAEEEFVNSIE-AWRRE 111
Cdd:PLN03087  194 QPKDNKAKEDVLFIHGFISSSAFWTETLfpnfsDAAKSTYRLFAVDLLGFGRS---PKPADSLYTLREHLEMIErSVLER 270

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1622147285 112 MGIPSMILLGHSLGGFLAASYSLQYPERVKHLILVDPWGFP 152
Cdd:PLN03087  271 YKVKSFHIVAHSLGCILALALAVKHPGAVKSLTLLAPPYYP 311
PLN02679 PLN02679
hydrolase, alpha/beta fold family protein
 33-147 1.42e-10

hydrolase, alpha/beta fold family protein


Pssm-ID: 178283 [Multi-domain]  Cd Length: 360  Bit Score: 61.39  E-value: 1.42e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285  33 WTVSLSPERGKGRTPLVMVHGFGGGIGLWILNLDSLSQRRPLHAFDLLGFGRSSRPP-FPRDAQGAEEEFVNSIEawrRE 111
Cdd:PLN02679   76 YLVKGSPEVTSSGPPVLLVHGFGASIPHWRRNIGVLAKNYTVYAIDLLGFGASDKPPgFSYTMETWAELILDFLE---EV 152

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1622147285 112 MGIPSmILLGHSLGGF---LAASYSlqYPERVKHLILVD 147
Cdd:PLN02679  153 VQKPT-VLIGNSVGSLacvIAASES--TRDLVRGLVLLN 188
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 43-148 2.97e-10

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 56.38  E-value: 2.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285  43 KGRTPLVMVHGFGGGIGLWILNLDSLSQR-RPLHAFDLlgfgrssrPPFPRDAQGAEEEFVNSIEAWRREMGIPSMILLG 121
Cdd:COG1075     3 ATRYPVVLVHGLGGSAASWAPLAPRLRAAgYPVYALNY--------PSTNGSIEDSAEQLAAFVDAVLAATGAEKVDLVG 74

                          90       100
                  ....*....|....*....|....*....
gi 1622147285 122 HSLGGFLAASY--SLQYPERVKHLILVDP 148
Cdd:COG1075    75 HSMGGLVARYYlkRLGGAAKVARVVTLGT 103
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 48-310 8.77e-10

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 57.87  E-value: 8.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285  48 LVMVHGFGGGIGLWilnLDSLSQRRPLHAFDLLGFGRSSRPPFPRDAQGAEEEFVNSIEAWRREmgipsmILLGHSLGGF 127
Cdd:pfam12697   1 VVLVHGAGLSAAPL---AALLAAGVAVLAPDLPGHGSSSPPPLDLADLADLAALLDELGAARPV------VLVGHSLGGA 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285 128 LAASYSLQYperVKHLILVDPWGFPmrpsdPAQIRAPPTWVKAVATVLGrsnplavlraagpwgpglvqRFRPDFKQKFA 207
Cdd:pfam12697  72 VALAAAAAA---LVVGVLVAPLAAP-----PGLLAALLALLARLGAALA--------------------APAWLAAESLA 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285 208 DFFDDDTISEYIYHCNAQTPSGEAGFKAMSEAFGWARRPMlerihlvrrdlPITLIYGANSWIDTSTGEKVKILRPGSYV 287
Cdd:pfam12697 124 RGFLDDLPADAEWAAALARLAALLAALALLPLAAWRDLPV-----------PVLVLAEEDRLVPELAQRLLAALAGARLV 192

                         250       260
                  ....*....|....*....|...
gi 1622147285 288 cdmAIPGASHHVYaDQPHAFNAA 310
Cdd:pfam12697 193 ---VLPGAGHLPL-DDPEEVAEA 211
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 48-180 2.78e-09

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 56.45  E-value: 2.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285  48 LVMVHGFGGGIGL-----WILNLDSLSqrrpLHAFDLLGFGRSSRPP--------FPRDAQgaeeEFVNSIeawRREMGI 114
Cdd:pfam12146   7 VVLVHGLGEHSGRyahlaDALAAQGFA----VYAYDHRGHGRSDGKRghvpsfddYVDDLD----TFVDKI---REEHPG 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622147285 115 PSMILLGHSLGGFLAASYSLQYPERVKHLILVDPWGFPmrpsdpaQIRAPPTWVKAVATVLGRSNP 180
Cdd:pfam12146  76 LPLFLLGHSMGGLIAALYALRYPDKVDGLILSAPALKI-------KPYLAPPILKLLAKLLGKLFP 134
PRK10349 PRK10349
pimeloyl-ACP methyl ester esterase BioH;
41-146 9.37e-09

pimeloyl-ACP methyl ester esterase BioH;


Pssm-ID: 137836 [Multi-domain]  Cd Length: 256  Bit Score: 55.41  E-value: 9.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285  41 RGKGRTPLVMVHGFGGGIGLWILNLDSLSQRRPLHAFDLLGFGRSSRPPFPRDAQGAEEEFVNSIEawrremgipSMILL 120
Cdd:PRK10349    9 KGQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGFGALSLADMAEAVLQQAPD---------KAIWL 79

                          90       100
                  ....*....|....*....|....*.
gi 1622147285 121 GHSLGGFLAASYSLQYPERVKHLILV 146
Cdd:PRK10349   80 GWSLGGLVASQIALTHPERVQALVTV 105
PLN02824 PLN02824
hydrolase, alpha/beta fold family protein
 46-148 5.15e-08

hydrolase, alpha/beta fold family protein


Pssm-ID: 178419 [Multi-domain]  Cd Length: 294  Bit Score: 53.20  E-value: 5.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285  46 TPLVMVHGFGGGIGLWILNLDSLSQRRPLHAFDLLGFGRSSRPPfPRDAQgaeEEFVNSIEAWRREM--------GIPSM 117
Cdd:PLN02824   30 PALVLVHGFGGNADHWRKNTPVLAKSHRVYAIDLLGYGYSDKPN-PRSAP---PNSFYTFETWGEQLndfcsdvvGDPAF 105

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1622147285 118 ILLgHSLGGFLAASYSLQYPERVKHLILVDP 148
Cdd:PLN02824  106 VIC-NSVGGVVGLQAAVDAPELVRGVMLINI 135
PRK10673 PRK10673
esterase;
38-163 2.07e-07

esterase;


Pssm-ID: 182637 [Multi-domain]  Cd Length: 255  Bit Score: 51.27  E-value: 2.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285  38 SPERGKGRTPLVMVHG-FGGGIGLWILNLDsLSQRRPLHAFDLLGFGRSSRPP---FPRDAQgaeeEFVNSIEawrrEMG 113
Cdd:PRK10673    9 TAQNPHNNSPIVLVHGlFGSLDNLGVLARD-LVNDHDIIQVDMRNHGLSPRDPvmnYPAMAQ----DLLDTLD----ALQ 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622147285 114 IPSMILLGHSLGGFLAASYSLQYPERVKHLILVD--PWGFPMRPSDP--AQIRA 163
Cdd:PRK10673   80 IEKATFIGHSMGGKAVMALTALAPDRIDKLVAIDiaPVDYHVRRHDEifAAINA 133
PRK03592 PRK03592
haloalkane dehalogenase; Provisional
 40-312 5.34e-06

haloalkane dehalogenase; Provisional


Pssm-ID: 235135  Cd Length: 295  Bit Score: 47.30  E-value: 5.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285  40 ERGKGRtPLVMVHGFGGGIGLWILNLDSLSQRRPLHAFDLLGFGRSSRPpfprDAQGAEEEFVNSIEAWRREMGIPSMIL 119
Cdd:PRK03592   23 ETGEGD-PIVFLHGNPTSSYLWRNIIPHLAGLGRCLAPDLIGMGASDKP----DIDYTFADHARYLDAWFDALGLDDVVL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285 120 LGHSLGGFLAASYSLQYPERVKHLILVDPwgfpmrpsdpaqIRAPPTWVKavatvlgrsnplavlraagpWGPGLVQRFR 199
Cdd:PRK03592   98 VGHDWGSALGFDWAARHPDRVRGIAFMEA------------IVRPMTWDD--------------------FPPAVRELFQ 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285 200 ----PDFKQKFAdfFDDDTISEYIYHCNAQTPSGEAGFKAMSEAF--GWARRPMLErihlVRRDLPI--------TLIYG 265
Cdd:PRK03592  146 alrsPGEGEEMV--LEENVFIERVLPGSILRPLSDEEMAVYRRPFptPESRRPTLS----WPRELPIdgepadvvALVEE 219

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622147285 266 ANSWIDTS-------TGEKVKILRPGSyVCDMA-----------IPGASHHVYADQPHAFNAAVA 312
Cdd:PRK03592  220 YAQWLATSdvpklliNAEPGAILTTGA-IRDWCrswpnqleitvFGAGLHFAQEDSPEEIGAAIA 283
Esterase_713_like-1 cd12808
Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated ...
 70-188 6.46e-06

Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; This family contains uncharacterized proteins similar to a novel bacterial esterase (Alcaligenes esterase 713) with the alpha/beta hydrolase fold but does not contain the GXSXXG pentapeptide around the active site serine residue as commonly seen in other enzymes of this class. Esterase 713 shows negligible sequence homology to other esterase and lipase enzymes. It is active as a dimer and cleaves esters on halogenated cyclic compounds though its natural substrate is unknown.


Pssm-ID: 214007  Cd Length: 309  Bit Score: 46.85  E-value: 6.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285  70 QRRPLHAFDllGFGRSSRPPFPRDAQGAEEEFVNSIEawrremGIPSMILLGHSLGGFLAASYSLQYPERVKHLILVDPW 149
Cdd:cd12808   151 QQFPLAAFD--AFAKQFVPRWLGTDALTLAAYDALLD------RVGPCIVVAHSQGGGFAFEAARARPDLVRAVVALEPS 222

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622147285 150 GFPMRPSDPA------------QIRAPPTWVKAVATVlgrSNPLAVLRAAG 188
Cdd:cd12808   223 GAPDPAEAAPladvphllvwgdYIDADPRWPRYRATV---DAYAAALRAAG 270
YpfH COG0400
Predicted esterase [General function prediction only];
42-145 2.69e-05

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 44.13  E-value: 2.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285  42 GKGRTPLVMVHGFGG----GIGLW-ILNLDSL------SQRRPLHA----FDLLGFGRSSRPPfprDAQGAEEEFVNSIE 106
Cdd:COG0400     2 GPAAPLVVLLHGYGGdeedLLPLApELALPGAavlaprAPVPEGPGgrawFDLSFLEGREDEE---GLAAAAEALAAFID 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1622147285 107 AWRREMGIPS--MILLGHSLGGFLAASYSLQYPERVKHLIL 145
Cdd:COG0400    79 ELEARYGIDPerIVLAGFSQGAAMALSLALRRPELLAGVVA 119
PLN03084 PLN03084
alpha/beta hydrolase fold protein; Provisional
 47-148 2.19e-04

alpha/beta hydrolase fold protein; Provisional


Pssm-ID: 178633  Cd Length: 383  Bit Score: 42.56  E-value: 2.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285  47 PLVMVHGFGGGIGLWILNLDSLSQRRPLHAFDLLGFGRSSRPPFPRDAQGAEEEFVNSIEAWRREMGIPSMILLGHSLGG 126
Cdd:PLN03084  129 PVLLIHGFPSQAYSYRKVLPVLSKNYHAIAFDWLGFGFSDKPQPGYGFNYTLDEYVSSLESLIDELKSDKVSLVVQGYFS 208

                          90       100
                  ....*....|....*....|..
gi 1622147285 127 FLAASYSLQYPERVKHLILVDP 148
Cdd:PLN03084  209 PPVVKYASAHPDKIKKLILLNP 230
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 29-149 5.09e-04

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 41.05  E-value: 5.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285  29 HAKIWTvslsPERGKGRTP-LVMVHGFGGGIGLWILNLDSLSQRRpLH--AFDLLGFGRSS-RP-----PFPRDAQGA-- 97
Cdd:COG1073    24 AGDLYL----PAGASKKYPaVVVAHGNGGVKEQRALYAQRLAELG-FNvlAFDYRGYGESEgEPreegsPERRDARAAvd 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622147285  98 ---EEEFVNsieawRREMGIpsmilLGHSLGGFLAASYSLQYPeRVKHLILVDPW 149
Cdd:COG1073    99 ylrTLPGVD-----PERIGL-----LGISLGGGYALNAAATDP-RVKAVILDSPF 142
MET2 COG2021
Homoserine O-acetyltransferase [Amino acid transport and metabolism]; Homoserine ...
 90-167 1.83e-03

Homoserine O-acetyltransferase [Amino acid transport and metabolism]; Homoserine O-acetyltransferase is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 441624 [Multi-domain]  Cd Length: 355  Bit Score: 39.69  E-value: 1.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285  90 FP----RDaqgaeeeFVNSIEAWRREMGIPS-MILLGHSLGGFLAASYSLQYPERVKHLILV------DPWG----FPMR 154
Cdd:COG2021   105 FPvvtiRD-------MVRAQKRLLDHLGIERlAAVIGGSMGGMQALEWAVSYPDRVRRAIVIataarlSAQNiafnEVQR 177

                          90
                  ....*....|...
gi 1622147285 155 psdpAQIRAPPTW 167
Cdd:COG2021   178 ----QAIRADPNW 186
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
44-164 2.90e-03

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 38.38  E-value: 2.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285  44 GRTPLVMVHGFGGG---IGLWIlnlDSLSQR-RPLHAFDLLGFGRSSRPPFPRDAqgaeEEFVNSIEAWRREM--GIPSM 117
Cdd:COG1647    14 GRKGVLLLHGFTGSpaeMRPLA---EALAKAgYTVYAPRLPGHGTSPEDLLKTTW----EDWLEDVEEAYEILkaGYDKV 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1622147285 118 ILLGHSLGGFLAASYSLQYPErVKHLILVDPwgfPMRPSDPAQIRAP 164
Cdd:COG1647    87 IVIGLSMGGLLALLLAARYPD-VAGLVLLSP---ALKIDDPSAPLLP 129
EntF2 COG3319
Thioesterase domain of type I polyketide synthase or non-ribosomal peptide synthetase ...
 33-187 9.39e-03

Thioesterase domain of type I polyketide synthase or non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442548 [Multi-domain]  Cd Length: 855  Bit Score: 37.76  E-value: 9.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285  33 WTVSLSPERGKGRTPLVMVHGfGGGIGLWILNL-DSLSQRRPLHAFDLLGFGRSSRPPfprdaqgaeeefvNSIEAWRRE 111
Cdd:COG3319   589 LSPLVPLRAGGSGPPLFCVHP-AGGNVLCYRPLaRALGPDRPVYGLQAPGLDGGEPPP-------------ASVEEMAAR 654

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622147285 112 MgIPSM---------ILLGHSLGGFLA---ASYSLQYPERVKHLILVDPWgfpmrPSDPAQIRAPPTWVKAVATVLGRSN 179
Cdd:COG3319   655 Y-VEAIravqpegpyHLLGWSFGGLVAyemARQLEAQGEEVALLVLLDSY-----APGALARLDEAELLAALLRDLARGV 728


                  ....*...
gi 1622147285 180 PLAVLRAA 187
Cdd:COG3319   729 DLPLDAEE 736
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH