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Conserved domains on  [gi|1370484583|ref|XP_024309396|]
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presenilin-associated rhomboid-like protein, mitochondrial isoform X5 [Homo sapiens]

Protein Classification

rhomboid family intramembrane serine protease( domain architecture ID 10483871)

rhomboid family intramembrane serine protease is a membrane-bound protein that catalyzes regulated intramembrane proteolysis, resulting in the release of functional polypeptides from their membrane anchor

CATH:  1.20.1540.10
EC:  3.4.21.-
Gene Ontology:  GO:0004252
MEROPS:  S54
PubMed:  22035660|24099005
SCOP:  4000471

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 18-159 9.52e-25

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


:

Pssm-ID: 426384  Cd Length: 147  Bit Score: 94.21  E-value: 9.52e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484583  18 MLLSTFSHFSLFHMAANMYVLWSFSSSIVNILGQEQFMAVYLSAGVISNFVSYvgkVATGRYGPSLGASGAIMTVLAAVC 97
Cdd:pfam01694  10 LITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSY---LFSPLSTPSVGASGAIFGLLGALL 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370484583  98 TKIPEGRLAIIFLPMFTFtagnALKAIIAMDTAGMILGWKFFDHAAHLGGALFGMISLYTWR 159
Cdd:pfam01694  87 VLGPRNRILLFGLIGALL----ALLLFILLNLVLGLLPGNGVSNLAHLGGLLVGLLLGFILL 144
 
Name Accession Description Interval E-value
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 18-159 9.52e-25

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 94.21  E-value: 9.52e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484583  18 MLLSTFSHFSLFHMAANMYVLWSFSSSIVNILGQEQFMAVYLSAGVISNFVSYvgkVATGRYGPSLGASGAIMTVLAAVC 97
Cdd:pfam01694  10 LITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSY---LFSPLSTPSVGASGAIFGLLGALL 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370484583  98 TKIPEGRLAIIFLPMFTFtagnALKAIIAMDTAGMILGWKFFDHAAHLGGALFGMISLYTWR 159
Cdd:pfam01694  87 VLGPRNRILLFGLIGALL----ALLLFILLNLVLGLLPGNGVSNLAHLGGLLVGLLLGFILL 144
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
 18-160 1.91e-20

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 84.14  E-value: 1.91e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484583  18 MLLSTFSHFSLFHMAANMYVLWSFSSSIVNILGQEQFMAVYLSAGVISNFVSYVgkVATGRYGPSLGASGAIMTVLAAVC 97
Cdd:COG0705    46 LLTSMFLHGGFLHLLFNMLALWVFGPLLERRLGSKRFLLLYLLSGLGGGLLQLL--FSPGSGYPLVGASGAIFGLLGALL 123

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370484583  98 TKIPEGRLAIIFLPMftfTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGMISLYTWRL 160
Cdd:COG0705   124 VLGPRRRVLLLFIPI---PALLFLLVWLLLGLLFGLLGGGGIAWEAHLGGLLAGLLLALLLRK 183
 
Name Accession Description Interval E-value
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 18-159 9.52e-25

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 94.21  E-value: 9.52e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484583  18 MLLSTFSHFSLFHMAANMYVLWSFSSSIVNILGQEQFMAVYLSAGVISNFVSYvgkVATGRYGPSLGASGAIMTVLAAVC 97
Cdd:pfam01694  10 LITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSY---LFSPLSTPSVGASGAIFGLLGALL 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370484583  98 TKIPEGRLAIIFLPMFTFtagnALKAIIAMDTAGMILGWKFFDHAAHLGGALFGMISLYTWR 159
Cdd:pfam01694  87 VLGPRNRILLFGLIGALL----ALLLFILLNLVLGLLPGNGVSNLAHLGGLLVGLLLGFILL 144
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
 18-160 1.91e-20

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 84.14  E-value: 1.91e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484583  18 MLLSTFSHFSLFHMAANMYVLWSFSSSIVNILGQEQFMAVYLSAGVISNFVSYVgkVATGRYGPSLGASGAIMTVLAAVC 97
Cdd:COG0705    46 LLTSMFLHGGFLHLLFNMLALWVFGPLLERRLGSKRFLLLYLLSGLGGGLLQLL--FSPGSGYPLVGASGAIFGLLGALL 123

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370484583  98 TKIPEGRLAIIFLPMftfTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGMISLYTWRL 160
Cdd:COG0705   124 VLGPRRRVLLLFIPI---PALLFLLVWLLLGLLFGLLGGGGIAWEAHLGGLLAGLLLALLLRK 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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