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Conserved domains on  [gi|1370476235|ref|XP_024307549|]
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zinc finger protein 561 isoform X4 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
202-398 4.00e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 4.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370476235 202 PVKTHKGEKSFECKECGRSFRNSSCLNDHIQIHTG-------IKPHKCTYCGKAFTRSTQLTEHVRT--HTG--IKPYEC 270
Cdd:COG5048   245 PSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSC 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370476235 271 KE--CGQAFAQYSGLSIHIRSHSGKKPYQCK--ECGKAFTT-----STSLIQHTRIHTGEKPYECV--ECGKTFITSSRR 339
Cdd:COG5048   325 PYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPllnnePPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNL 404

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370476235 340 SKHLKTHSGEKPFVCK--ICGKAFLYSSRLNVHLRTHTGEKPFVCkECGKAFAVSSRLSRH 398
Cdd:COG5048   405 SLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
202-398 4.00e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 4.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370476235 202 PVKTHKGEKSFECKECGRSFRNSSCLNDHIQIHTG-------IKPHKCTYCGKAFTRSTQLTEHVRT--HTG--IKPYEC 270
Cdd:COG5048   245 PSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSC 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370476235 271 KE--CGQAFAQYSGLSIHIRSHSGKKPYQCK--ECGKAFTT-----STSLIQHTRIHTGEKPYECV--ECGKTFITSSRR 339
Cdd:COG5048   325 PYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPllnnePPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNL 404

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370476235 340 SKHLKTHSGEKPFVCK--ICGKAFLYSSRLNVHLRTHTGEKPFVCkECGKAFAVSSRLSRH 398
Cdd:COG5048   405 SLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
366-390 2.70e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 2.70e-04
                          10        20
                  ....*....|....*....|....*
gi 1370476235 366 RLNVHLRTHTGEKPFVCKECGKAFA 390
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
PHA00733 PHA00733
hypothetical protein
 265-314 9.09e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.39  E-value: 9.09e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1370476235 265 IKPYECKECGQAFAQYSGLSIHIR--SHSGKKPYqckeCGKAFTTSTSLIQH 314
Cdd:PHA00733   71 VSPYVCPLCLMPFSSSVSLKQHIRytEHSKVCPV----CGKEFRNTDSTLDH 118
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
202-398 4.00e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 4.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370476235 202 PVKTHKGEKSFECKECGRSFRNSSCLNDHIQIHTG-------IKPHKCTYCGKAFTRSTQLTEHVRT--HTG--IKPYEC 270
Cdd:COG5048   245 PSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSC 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370476235 271 KE--CGQAFAQYSGLSIHIRSHSGKKPYQCK--ECGKAFTT-----STSLIQHTRIHTGEKPYECV--ECGKTFITSSRR 339
Cdd:COG5048   325 PYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPllnnePPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNL 404

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370476235 340 SKHLKTHSGEKPFVCK--ICGKAFLYSSRLNVHLRTHTGEKPFVCkECGKAFAVSSRLSRH 398
Cdd:COG5048   405 SLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
193-347 1.46e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 1.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370476235 193 FTNFSQLYAPVKTHKGEKSFECKE--CGRSFRNSSCLNDHIQIHTGIKPHKCTYC-------GKAFTRSTQLTEHVRTHT 263
Cdd:COG5048   303 SPLTRHLRSVNHSGESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLK 382

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370476235 264 GIKPYEC--KECGQAFAQYSGLSIHIRSHSGKKPYQCK--ECGKAFTTSTSLIQHTRIHTGEKPYECVECGktfitSSRR 339
Cdd:COG5048   383 NDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILK-----SFRR 457


                  ....*...
gi 1370476235 340 SKHLKTHS 347
Cdd:COG5048   458 DLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
210-291 7.84e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 7.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370476235 210 KSFECKECGRSFRNSSCLNDHIQIHTGIKPHKCTY--CGKAFTRSTQLTEHVRTHTGIKPYECKECGQAFAQYSGLSIHI 287
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111


                  ....
gi 1370476235 288 RSHS 291
Cdd:COG5048   112 SSSS 115
zf-H2C2_2 pfam13465
Zinc-finger double domain;
366-390 2.70e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 2.70e-04
                          10        20
                  ....*....|....*....|....*
gi 1370476235 366 RLNVHLRTHTGEKPFVCKECGKAFA 390
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
283-307 8.11e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.11e-04
                          10        20
                  ....*....|....*....|....*
gi 1370476235 283 LSIHIRSHSGKKPYQCKECGKAFTT 307
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
227-251 8.86e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.86e-04
                          10        20
                  ....*....|....*....|....*
gi 1370476235 227 LNDHIQIHTGIKPHKCTYCGKAFTR 251
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
255-279 1.13e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.13e-03
                          10        20
                  ....*....|....*....|....*
gi 1370476235 255 LTEHVRTHTGIKPYECKECGQAFAQ 279
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
266-326 1.43e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 1.43e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370476235 266 KPYECKECGQAFAQYSGLSIHIRSHSGKKPYQC--KECGKAFTTSTSLIQHTRIHTGEKPYEC 326
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN 94
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
293-366 1.56e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 1.56e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370476235 293 KKPYQCKECGKAFTTSTSLIQHTRIHTGEKPYEC--VECGKTFITSSRRSKHLKTHSGEKPFVCKICGKAFLYSSR 366
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKAS 106
zf-H2C2_2 pfam13465
Zinc-finger double domain;
310-335 3.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.43e-03
                          10        20
                  ....*....|....*....|....*.
gi 1370476235 310 SLIQHTRIHTGEKPYECVECGKTFIT 335
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 240-262 3.53e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 3.53e-03
                          10        20
                  ....*....|....*....|...
gi 1370476235 240 HKCTYCGKAFTRSTQLTEHVRTH 262
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 296-318 5.87e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 5.87e-03
                          10        20
                  ....*....|....*....|...
gi 1370476235 296 YQCKECGKAFTTSTSLIQHTRIH 318
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
 265-314 9.09e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.39  E-value: 9.09e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1370476235 265 IKPYECKECGQAFAQYSGLSIHIR--SHSGKKPYqckeCGKAFTTSTSLIQH 314
Cdd:PHA00733   71 VSPYVCPLCLMPFSSSVSLKQHIRytEHSKVCPV----CGKEFRNTDSTLDH 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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