transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta superfamily consists of a large group of cell regulatory proteins, such as TFG-betas, Nodal, Activins/Inhibins, glial cell-line-derived neurotrophic factor (GDNF) family of ligands, bone morphogenetic proteins (BMPs), and growth and differentiation factors (GDFs). They play important roles in developmental and physiological processes in a variety of species, including invertebrates as well as vertebrates, through specific receptor complexes that are composed of type I and type II serine/threonine receptor kinases. The receptor kinases subsequently activate Smad proteins, which then propagate the signals into the nucleus to regulate target gene expression. Proteins from the TGF-beta superfamily are only active as homo- or heterodimer.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370454308 203 RQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 258
Cdd:cd19398     1 RQVCKRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 56

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 8A (BMP-8A), 8B (BMP-8B) and similar proteins; BMP-8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis. BMP-8B, also termed BMP-8, or osteogenic protein 2 (OP-2), may act as secreted factor in cancer progression. It also plays an essential role in bone metabolism and can regulate thermogenesis and energy balance. Like BMP-8A, BMP-8B plays a role in spermatogenesis and placental development. Mutation in either of the genes encoding BMP-8A or BMP-8B causes postnatal depletion of spermatogonia in mice.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370454308 203 RQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 258
Cdd:cd19398     1 RQVCKRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 56

Transforming growth factor beta like domain;

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370454308 206 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 258
Cdd:pfam00019   2 CRRHSLYVDFEDLGWDDWIIAPKGYNAYYCSGSCPSHLNPQLSATNHAILQSL 54

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 8A (BMP-8A), 8B (BMP-8B) and similar proteins; BMP-8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis. BMP-8B, also termed BMP-8, or osteogenic protein 2 (OP-2), may act as secreted factor in cancer progression. It also plays an essential role in bone metabolism and can regulate thermogenesis and energy balance. Like BMP-8A, BMP-8B plays a role in spermatogenesis and placental development. Mutation in either of the genes encoding BMP-8A or BMP-8B causes postnatal depletion of spermatogonia in mice.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370454308 203 RQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 258
Cdd:cd19398     1 RQVCKRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 56

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 (BMP-7) and similar proteins; BMP-7, also termed osteogenic protein 1 (OP-1), or eptotermin alfa, induces cartilage and bone formation. It may act as the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis and play a role in calcium regulation and bone homeostasis.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370454308 203 RQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 258
Cdd:cd19397     3 RQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTL 58

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 5 (BMP-5) and similar proteins; BMP-5 induces cartilage and bone formation.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370454308 196 DVHGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 258
Cdd:cd19395     2 DYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTL 64

transforming growth factor beta (TGF-beta) like domain found in the BMP/GDF family; The BMP/GDF family consists of bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and similar proteins. BMPs are a group of growth factors also known as cytokines and as metabologens. They induce the formation of bone and cartilage and functions as pivotal morphogenetic signals, orchestrating tissue architecture throughout the body. GDFs have functions predominantly in development.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370454308 206 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 258
Cdd:cd13756     1 CRRRPLYVDFSDLGWDDWIIAPKGYNANYCAGSCPFPLSSHANATNHAILQAL 53

transforming growth factor beta (TGF-beta) like domain found in Strongylocentrotus purpuratus univin and similar proteins; Univin may have a critical role in early developmental decisions in the sea urchin embryo.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1370454308 205 VCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 258
Cdd:cd19387     2 ICQRHSLYVDFKDVGWSDWIIAPRGYQAYRCAGECPFPLNEHLNGTNHAIIQTL 55

transforming growth factor beta (TGF-beta) like domain found in anti-dorsalizing morphogenetic protein (ADMP) and similar proteins; ADMP is a bone morphogenetic protein (BMP)-like transforming growth factor beta ligand, functions in the trunk organizer to antagonize head formation, thereby regulating organizer patterning. It negatively affects the formation of the organizer, although it is robustly expressed within the organizer itself. The organizer-promoting signal of ADMP is mediated by the activin A type I receptor, ACVR1 (also known as activin receptor-like kinase-2, ALK2).

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370454308 206 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 258
Cdd:cd13765     3 CQRHELYVDFEEIGWSGWIISPKGYNAYHCKGSCPFPLGQNQKPTNHATVQSI 55

transforming growth factor beta (TGF-beta) like domain found in embryonic growth/differentiation factor 1 (GDF1), factor 3 (GDF3) and similar proteins; The family includes GDF-1 and GDF-3. GDF1 may mediate cell differentiation events during embryonic development. GDF3 is a growth factor involved in early embryonic development and adipose-tissue homeostasis. The family also contains protein DVR-1, also termed vegetal hemisphere VG1 protein (VG-1), which serves to facilitate the differentiation of either mesoderm or endoderm either as a cofactor in an instructive signal or by providing permissive environment.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370454308 206 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 258
Cdd:cd13764     1 CKKRRLYISFRDVGWQNWIIAPQGYMANYCHGECPFPLTESLNGTNHAILQTL 53

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins; BMP-4, also termed BMP-2B, induces cartilage and bone formation. It also acts in mesoderm induction, tooth development, limb formation and fracture repair.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370454308 206 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 258
Cdd:cd19391     7 CRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTL 59

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 (BMP-3), growth/differentiation factor 10 (GDF10) and similar proteins; The family includes BMP-3 (also known as BMP-3A or osteogenin) and GDF10 (also known as BMP-3B). BMP-3 negatively regulates bone density. It antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification. GDF10 is a growth factor involved in osteogenesis and adipogenesis.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370454308 206 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 258
Cdd:cd13763     1 CSRRPLTVDFADIGWSDWIISPKSFDAYYCAGSCPFPLTKELRPSNHATIQSI 53

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 5 (GDF5) and similar proteins; GDF5, also termed bone morphogenetic protein 14 (BMP-14), or cartilage-derived morphogenetic protein 1 (CDMP-1), or lipopolysaccharide-associated protein 4 (LAP-4), or LPS-associated protein 4, or radotermin, is a growth factor involved in bone and cartilage formation.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370454308 206 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 258
Cdd:cd19399     2 CSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTL 54

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 9 (GDF-9), growth/differentiation factor 9B (GDF-9B) and similar proteins; The family includes GDF-9B (also known as BMP15) and GDF9. GDF-9B acts as oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. GDF-9 is required for ovarian folliculogenesis. It promotes primordial follicle development and stimulates granulosa cell proliferation.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370454308 206 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 258
Cdd:cd13762     3 CRRHRLRVRFRDLKWNGWIIAPTRYTANYCKGTCPRVLGQDLNPTNHAIVQNI 55

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 10 (BMP-10) and similar proteins; BMP-10 is required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. It inhibits endothelial cell migration and growth. It may reduce cell migration and cell matrix adhesion in breast cancer cell lines.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370454308 206 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 258
Cdd:cd19401     3 CKRSPLYVDFKEIGWDSWIIAPTGYEAYECRGVCYYPLTEHVTPTKHAIVQTL 55

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 (BMP-3) and similar proteins; BMP-3, also termed BMP-3A, or osteogenin, negatively regulates bone density. It antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370454308 206 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 258
Cdd:cd19393     8 CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSI 60

transforming growth factor beta (TGF-beta) like domain found in mammalian growth/differentiation factor 15 (GDF-15) and similar proteins; GDF-15, also termed macrophage inhibitory cytokine 1 (MIC-1), or NSAID-activated gene 1 protein (NAG-1), or NSAID-regulated gene 1 protein (NRG-1), or placental TGF-beta, or placental bone morphogenetic protein, or prostate differentiation factor, regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370454308 206 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSfplDSCMNATNHAILQSL 258
Cdd:cd19376     3 CCRFSLRVSFKEIGWADWVLAPESYNAYYCDGSCP---HNYKPANMHAQIKSR 52

transforming growth factor beta (TGF-beta) like domain found in inhibin alpha chain (INHA), beta chain (INHB) and similar proteins; INHA is a component of inhibins (inhibin A or inhibin B) that inhibit the secretion of follitropin by the pituitary gland. INHB includes inhibin beta A chain (INHBA), B chain (INHBB), C chain (INHBC), and E chain (INHBE). INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBB, also termed activin beta-B chain, is a component of inhibin B, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBC, also termed activin beta-C chain, might play important roles in carcinogenesis. It may function as a negative regulator of liver growth. INHBE, also termed activin beta-E chain, is a possible insulin resistance-associated hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. It also acts as a possible new marker for drug-induced endoplasmic reticulum stress.

                          10        20        30
                  ....*....|....*....|....*....|....
gi 1370454308 206 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGEC 239
Cdd:cd19377     1 CCRVALFVSFEELGWNRWIIAPPGFNFHFCHGGC 34

transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins; INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland.

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1370454308 205 VCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGEC 239
Cdd:cd19404     2 ICCKKQFYVSFKDIGWSDWIIAPSGYHANYCEGEC 36

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 8 (GDF8) and similar proteins; GDF8, also termed myostatin, acts specifically as a negative regulator of skeletal muscle growth.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1370454308 196 DVHGSHGRqvCRRHELYVSFQDLGWlDWVIAPQGYSAYYCEGECSF 241
Cdd:cd19388     6 DEHSTESR--CCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGECEF 48

transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1), beta-2 (TGF-beta-2), beta-3 (TGF-beta-3) and similar proteins; The family includes TGF-beta-1, TGF-beta-2 and TGF-beta-3, which are polypeptide members of the transforming growth factor beta superfamily of cytokines. TGF-beta-1 is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, and apoptosis. TGF-beta-2 is a secreted protein that performs many cellular functions and has a vital role during embryonic development. It can suppress the effects of interleukin-2 dependent T-cell growth. TGF-beta-3 is involved in embryogenesis and cell differentiation. It regulates molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1370454308 206 CRRHELYVSFQ-DLGWlDWVIAPQGYSAYYCEGECSFPLDSCMNAT 250
Cdd:cd13753     1 CCLRPLYINFRrDLGW-KWIHEPKGFNANYCAGACPYLWSADTQHS 45

transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster maverick and similar proteins; Maverick, also termed MAV, is a novel member of the TGF-beta superfamily in Drosophila. It's a bone morphogenetic protein (BMP)/TGF-beta related ligand.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1370454308 206 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECsfPLDScmN-ATNHAILQSL 258
Cdd:cd13755     4 CCRHSLKVDFKKLPGFEWIIQPKEFDAGYCKGRC--PPRY--NyANNHALIQSL 53

transforming growth factor beta (TGF-beta) like domain found in Caenorhabditis elegans Dauer larva development regulatory growth factor DAF-7 and similar proteins; DAF-7, also termed abnormal dauer formation protein 7, may act as a negative regulator of dauer larva development by transducing chemosensory information from ASI neurons. It is involved in sensitivity to CO2 levels.

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1370454308 206 CRRHELYVSFQDLGWlDWVIAPQGYSAYYCEGECS 240
Cdd:cd19378     3 CCLYDLTIDFEEIGW-NFIIAPKKYNANMCRGDCK 36

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 11 (GDF11) and similar proteins; GDF11, also termed bone morphogenetic protein 11 (BMP-11), is a secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1370454308 192 GIFDDVHGSHGRqvCRRHELYVSFQDLGWlDWVIAPQGYSAYYCEGECSF 241
Cdd:cd19389     3 GLDCDEHSTESR--CCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGQCEY 49

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 9 (GDF-9) and similar proteins; GDF-9 is required for ovarian folliculogenesis. It promotes primordial follicle development and stimulates granulosa cell proliferation.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370454308 206 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 258
Cdd:cd19403     5 CELHDFRLSFSQLKWDHWIIAPHRYNPRYCKGSCPRAVGHRYGSPVHTMVQNI 57

transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-2 (TGF-beta-2) and similar proteins; TGF-beta-2, also termed BSC-1 cell growth inhibitor, or cetermin, or glioblastoma-derived T-cell suppressor factor (G-TSF), or polyergin, is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions and has a vital role during embryonic development. It can suppress the effects of interleukin-2 dependent T-cell growth.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1370454308 206 CRRHELYVSFQ-DLGWlDWVIAPQGYSAYYCEGECSFPLDScmnATNHAILQSL 258
Cdd:cd19385     1 CCLRPLYIDFKrDLGW-KWIHEPKGYNANFCAGACPYLWSS---DTQHSRVLSL 50

transforming growth factor beta (TGF-beta) like domain found in Danio rerio gonadal somatic cell derived factor (GSDF) and similar proteins; GSDF is a new member of transforming growth factor beta (TGF-beta) superfamily. It is a teleost- and gonad-specific growth factor that controls sex determination in some fish and plays an important role in mediating germ cell/soma signaling.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1370454308 206 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGecsfpldsCMNATNHAILQSLE 259
Cdd:cd19379     3 CCQETSEIFFKDLGWENWVIYPESFTYVQCVG--------CNAGRNSSESQCRQ 48