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Conserved domains on  [gi|1333701020|ref|XP_023502916|]
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ataxin-2 isoform X6 [Equus caballus]

Protein Classification

Sm_like and LsmAD domain-containing protein( domain architecture ID 10627809)

protein containing domains Sm_like, LsmAD, PAM2, and PHA03247

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 263-336 5.21e-21

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


:

Pssm-ID: 464173  Cd Length: 78  Bit Score: 88.38  E-value: 5.21e-21
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1333701020  263 MVHILTSVVGSKCEVQVKNGGIYEGVFKTYSP--KCDLVLDAAHEKSTESSSG--PKREEIMESILFKCSDFVVVQFK 336
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASLekDFGVVLKMARRIKKSNGSGlnPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 404-465 9.86e-16

LsmAD domain; This domain is found associated with Lsm domain.


:

Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 72.60  E-value: 9.86e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1333701020  404 YGVVSTYDSSLssYTVPLERdNSEEFLKREARANQLAEEIESSAQYKARVALENDDR------SEEEK 465
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERGLDvddsglDEEDK 65
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 924-1240 8.25e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 8.25e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020  924 PKPSTTPTSPRPQAQPSP--SMVGHQQPTPVYTQPVCFAPNMMYPVPVSPGVQ------PLYPIPMTPMPVNQAKTYRAV 995
Cdd:PHA03247  2674 AQASSPPQRPRRRAARPTvgSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAaarqasPALPAAPAPPAVPAGPATPGG 2753

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020  996 PNMPQQRQDQHHQSAMMHPAS-AAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPhyqSQHPHVYSPVIQGNARMMAP 1074
Cdd:PHA03247  2754 PARPARPPTTAGPPAPAPPAApAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPAGPLPP 2830

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020 1075 PTHAQP-------GLVSSSATQYGA------------HEQTHAMYACPKLPYNKETsPSFYFAISTGSLAQQyahPNATL 1135
Cdd:PHA03247  2831 PTSAQPtapppppGPPPPSLPLGGSvapggdvrrrppSRSPAAKPAAPARPPVRRL-ARPAVSRSTESFALP---PDQPE 2906

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020 1136 HPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNSfpa 1215
Cdd:PHA03247  2907 RPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA--- 2983

                          330       340
                   ....*....|....*....|....*
gi 1333701020 1216 aqqtvftihPSHVQPAYTNPPHMAH 1240
Cdd:PHA03247  2984 ---------PSREAPASSTPPLTGH 2999
PAM2 pfam07145
Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various ...
 905-920 5.45e-03

Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various eukaryotic proteins as an important binding site for pfam00658. It has been found in a wide range of eukaryotic proteins. Strikingly, this motif appears to occur solely outside of globular domains.


:

Pssm-ID: 429316  Cd Length: 17  Bit Score: 35.28  E-value: 5.45e-03
                           10
                   ....*....|....*.
gi 1333701020  905 RKSTLNPNAKEFNPRS 920
Cdd:pfam07145    1 SKSKLNPNAKEFVPSF 16
 
Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 263-336 5.21e-21

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


Pssm-ID: 464173  Cd Length: 78  Bit Score: 88.38  E-value: 5.21e-21
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1333701020  263 MVHILTSVVGSKCEVQVKNGGIYEGVFKTYSP--KCDLVLDAAHEKSTESSSG--PKREEIMESILFKCSDFVVVQFK 336
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASLekDFGVVLKMARRIKKSNGSGlnPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 404-465 9.86e-16

LsmAD domain; This domain is found associated with Lsm domain.


Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 72.60  E-value: 9.86e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1333701020  404 YGVVSTYDSSLssYTVPLERdNSEEFLKREARANQLAEEIESSAQYKARVALENDDR------SEEEK 465
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERGLDvddsglDEEDK 65
PHA03247 PHA03247
large tegument protein UL36; Provisional
 924-1240 8.25e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 8.25e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020  924 PKPSTTPTSPRPQAQPSP--SMVGHQQPTPVYTQPVCFAPNMMYPVPVSPGVQ------PLYPIPMTPMPVNQAKTYRAV 995
Cdd:PHA03247  2674 AQASSPPQRPRRRAARPTvgSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAaarqasPALPAAPAPPAVPAGPATPGG 2753

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020  996 PNMPQQRQDQHHQSAMMHPAS-AAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPhyqSQHPHVYSPVIQGNARMMAP 1074
Cdd:PHA03247  2754 PARPARPPTTAGPPAPAPPAApAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPAGPLPP 2830

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020 1075 PTHAQP-------GLVSSSATQYGA------------HEQTHAMYACPKLPYNKETsPSFYFAISTGSLAQQyahPNATL 1135
Cdd:PHA03247  2831 PTSAQPtapppppGPPPPSLPLGGSvapggdvrrrppSRSPAAKPAAPARPPVRRL-ARPAVSRSTESFALP---PDQPE 2906

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020 1136 HPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNSfpa 1215
Cdd:PHA03247  2907 RPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA--- 2983

                          330       340
                   ....*....|....*....|....*
gi 1333701020 1216 aqqtvftihPSHVQPAYTNPPHMAH 1240
Cdd:PHA03247  2984 ---------PSREAPASSTPPLTGH 2999
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 925-1097 8.61e-06

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 50.42  E-value: 8.61e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020  925 KPSTTPTSPRPQAQPSPSMVGHQ--------------QPTPVYTQPvcfaPNMMYPVPVSPGVQPLYPIPMTPMPVNQAK 990
Cdd:pfam09770  169 KAAAPAPAPQPAAQPASLPAPSRkmmsleeveaamraQAKKPAQQP----APAPAQPPAAPPAQQAQQQQQFPPQIQQQQ 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020  991 TYRAVPNMPQQRQDQHHQ-SAMMHPASAAGPPIVATPPaystqyvAYSPQQFPNQPLVQHVPHYQSQHPHVYSPV---IQ 1066
Cdd:pfam09770  245 QPQQQPQQPQQHPGQGHPvTILQRPQSPQPDPAQPSIQ-------PQAQQFHQQPPPVPVQPTQILQNPNRLSAArvgYP 317

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1333701020 1067 GNARMMAPPTHAQPGLVSSSATQYGAHEQTH 1097
Cdd:pfam09770  318 QNPQPGVQPAPAHQAHRQQGSFGRQAPIITH 348
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 932-1045 6.92e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 47.11  E-value: 6.92e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020  932 SPRPQAQPSPS-MVGHQQPTPVYTQpvcfAPNMMYP-VPVSPGVQPLYPIPMTPMPVNQAKTYravPNMPQQRQDQHHQS 1009
Cdd:TIGR01628  379 QPRMRQLPMGSpMGGAMGQPPYYGQ----GPQQQFNgQPLGWPRMSMMPTPMGPGGPLRPNGL---APMNAVRAPSRNAQ 451

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1333701020 1010 AMMHPASAagPPIVATPPAYSTQyvaySPQQFPNQP 1045
Cdd:TIGR01628  452 NAAQKPPM--QPVMYPPNYQSLP----LSQDLPQPQ 481
PAM2 pfam07145
Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various ...
 905-920 5.45e-03

Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various eukaryotic proteins as an important binding site for pfam00658. It has been found in a wide range of eukaryotic proteins. Strikingly, this motif appears to occur solely outside of globular domains.


Pssm-ID: 429316  Cd Length: 17  Bit Score: 35.28  E-value: 5.45e-03
                           10
                   ....*....|....*.
gi 1333701020  905 RKSTLNPNAKEFNPRS 920
Cdd:pfam07145    1 SKSKLNPNAKEFVPSF 16
Sm_like cd00600
Sm and related proteins; The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to ...
 267-334 9.26e-03

Sm and related proteins; The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of this family share a highly conserved Sm fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta-sheet. Sm-like proteins exist in archaea as well as prokaryotes that form heptameric and hexameric ring structures similar to those found in eukaryotes.


Pssm-ID: 212462 [Multi-domain]  Cd Length: 63  Bit Score: 36.07  E-value: 9.26e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1333701020  267 LTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTEsssgpKREEIMESILFKCSDFVVVQ 334
Cdd:cd00600      1 LKDFIGKTVSVELKDGRVLTGTLVAFDKYMNLVLDDVVETGRD-----GKVRVLGLVLIRGSNIVSIR 63
 
Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 263-336 5.21e-21

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


Pssm-ID: 464173  Cd Length: 78  Bit Score: 88.38  E-value: 5.21e-21
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1333701020  263 MVHILTSVVGSKCEVQVKNGGIYEGVFKTYSP--KCDLVLDAAHEKSTESSSG--PKREEIMESILFKCSDFVVVQFK 336
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASLekDFGVVLKMARRIKKSNGSGlnPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 404-465 9.86e-16

LsmAD domain; This domain is found associated with Lsm domain.


Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 72.60  E-value: 9.86e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1333701020  404 YGVVSTYDSSLssYTVPLERdNSEEFLKREARANQLAEEIESSAQYKARVALENDDR------SEEEK 465
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERGLDvddsglDEEDK 65
PHA03247 PHA03247
large tegument protein UL36; Provisional
 924-1240 8.25e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 8.25e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020  924 PKPSTTPTSPRPQAQPSP--SMVGHQQPTPVYTQPVCFAPNMMYPVPVSPGVQ------PLYPIPMTPMPVNQAKTYRAV 995
Cdd:PHA03247  2674 AQASSPPQRPRRRAARPTvgSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAaarqasPALPAAPAPPAVPAGPATPGG 2753

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020  996 PNMPQQRQDQHHQSAMMHPAS-AAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPhyqSQHPHVYSPVIQGNARMMAP 1074
Cdd:PHA03247  2754 PARPARPPTTAGPPAPAPPAApAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPAGPLPP 2830

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020 1075 PTHAQP-------GLVSSSATQYGA------------HEQTHAMYACPKLPYNKETsPSFYFAISTGSLAQQyahPNATL 1135
Cdd:PHA03247  2831 PTSAQPtapppppGPPPPSLPLGGSvapggdvrrrppSRSPAAKPAAPARPPVRRL-ARPAVSRSTESFALP---PDQPE 2906

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020 1136 HPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNSfpa 1215
Cdd:PHA03247  2907 RPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA--- 2983

                          330       340
                   ....*....|....*....|....*
gi 1333701020 1216 aqqtvftihPSHVQPAYTNPPHMAH 1240
Cdd:PHA03247  2984 ---------PSREAPASSTPPLTGH 2999
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 925-1097 8.61e-06

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 50.42  E-value: 8.61e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020  925 KPSTTPTSPRPQAQPSPSMVGHQ--------------QPTPVYTQPvcfaPNMMYPVPVSPGVQPLYPIPMTPMPVNQAK 990
Cdd:pfam09770  169 KAAAPAPAPQPAAQPASLPAPSRkmmsleeveaamraQAKKPAQQP----APAPAQPPAAPPAQQAQQQQQFPPQIQQQQ 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020  991 TYRAVPNMPQQRQDQHHQ-SAMMHPASAAGPPIVATPPaystqyvAYSPQQFPNQPLVQHVPHYQSQHPHVYSPV---IQ 1066
Cdd:pfam09770  245 QPQQQPQQPQQHPGQGHPvTILQRPQSPQPDPAQPSIQ-------PQAQQFHQQPPPVPVQPTQILQNPNRLSAArvgYP 317

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1333701020 1067 GNARMMAPPTHAQPGLVSSSATQYGAHEQTH 1097
Cdd:pfam09770  318 QNPQPGVQPAPAHQAHRQQGSFGRQAPIITH 348
PHA03247 PHA03247
large tegument protein UL36; Provisional
 918-1287 2.18e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 2.18e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020  918 PRSFSQPKPSTTPTSPRPQAQPSPSmvghqQPTPVYTQPVCFAPNmmyPVPVSPGVQPLYPIPMTPMPVNQAKTYRAVPN 997
Cdd:PHA03247  2593 PQSARPRAPVDDRGDPRGPAPPSPL-----PPDTHAPDPPPPSPS---PAANEPDPHPPPTVPPPERPRDDPAPGRVSRP 2664

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020  998 MPQQRQDQhhqsammhPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMMAPPTH 1077
Cdd:PHA03247  2665 RRARRLGR--------AAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALP 2736

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020 1078 AQP-------GLVSSSATQYGAHEQTHAMYACPKLPYNKETSPSFYFAISTGSLAQQYAHPNATLHPHTPHPQPSATPTG 1150
Cdd:PHA03247  2737 AAPappavpaGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAA 2816

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020 1151 ---QQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPqnSFPAAQQTVFTIHPSH 1227
Cdd:PHA03247  2817 alpPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAP--ARPPVRRLARPAVSRS 2894

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020 1228 VQPAYTNPPHMAHVPQAHVQSGMVPSHPTAHAPMMLMTTQPPGGPQAALAQSAlQPIPVS 1287
Cdd:PHA03247  2895 TESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTT-DPAGAG 2953
PHA03247 PHA03247
large tegument protein UL36; Provisional
 925-1285 2.43e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 2.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020  925 KPSTTPTSPRPQAQPSPSMVGHQQPTPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAVPNMPQQRQd 1004
Cdd:PHA03247  2588 RPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRR- 2666

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020 1005 qhhQSAMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMMAPPTHAQP---- 1080
Cdd:PHA03247  2667 ---ARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPappa 2743

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020 1081 ---GLVSSSATQYGAHEQTHAMYACPKLPYNKETSPSFyfAISTGSLAQQYAHPNATLHPHTPHPQPSATPtGQQQSQHG 1157
Cdd:PHA03247  2744 vpaGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR--RLTRPAVASLSESRESLPSPWDPADPPAAVL-APAAALPP 2820

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020 1158 GSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAP----------TPPSMTPASNTQSPQNSF--PAAQQTV--FTI 1223
Cdd:PHA03247  2821 AASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvrrrppsRSPAAKPAAPARPPVRRLarPAVSRSTesFAL 2900

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1333701020 1224 HPSHVQPAYTNPPHMAHVPQAHVQSGMVPSHPTAHAPMMLMTTQPPGGPQAALAQSALQPIP 1285
Cdd:PHA03247  2901 PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQP 2962
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 1013-1267 4.46e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 48.11  E-value: 4.46e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020 1013 HPASAAGPPIVATPPAYSTQY-VAYSPQQFPNQPLVQHVPHYQSQHP----HVySPVIQGNARMMAPPTHAQPGLVSSSA 1087
Cdd:pfam09770  106 QPAARAAQSSAQPPASSLPQYqYASQQSQQPSKPVRTGYEKYKEPEPipdlQV-DASLWGVAPKKAAAPAPAPQPAAQPA 184

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020 1088 TQYGAH-------EQTHAMYACPKLPYNKETSPSFYFAistgslaQQYAHPNATLHPHTPHPQPSATPTGQQQSQHGGSH 1160
Cdd:pfam09770  185 SLPAPSrkmmsleEVEAAMRAQAKKPAQQPAPAPAQPP-------AAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHP 257

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020 1161 PAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPqNSFPAAQQTVFTIHPSHVQPAytnPPHMAH 1240
Cdd:pfam09770  258 GQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNP-NRLSAARVGYPQNPQPGVQPA---PAHQAH 333

                          250       260
                   ....*....|....*....|....*..
gi 1333701020 1241 vPQAHVQSGMVPSHpTAHAPMMLMTTQ 1267
Cdd:pfam09770  334 -RQQGSFGRQAPII-THPQQLAQLSEE 358
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 932-1045 6.92e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 47.11  E-value: 6.92e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020  932 SPRPQAQPSPS-MVGHQQPTPVYTQpvcfAPNMMYP-VPVSPGVQPLYPIPMTPMPVNQAKTYravPNMPQQRQDQHHQS 1009
Cdd:TIGR01628  379 QPRMRQLPMGSpMGGAMGQPPYYGQ----GPQQQFNgQPLGWPRMSMMPTPMGPGGPLRPNGL---APMNAVRAPSRNAQ 451

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1333701020 1010 AMMHPASAagPPIVATPPAYSTQyvaySPQQFPNQP 1045
Cdd:TIGR01628  452 NAAQKPPM--QPVMYPPNYQSLP----LSQDLPQPQ 481
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 922-1210 9.34e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 47.00  E-value: 9.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020  922 SQPKPSTTPTSPRPQAQPSPsmvGHQQPTPVYT-QPVCFAPNMMYPVPVSPGVQPLYPiPMTPMPVNQAKTYRAVPNMPQ 1000
Cdd:PRK10263   345 PVASVDVPPAQPTVAWQPVP---GPQTGEPVIApAPEGYPQQSQYAQPAVQYNEPLQQ-PVQPQQPYYAPAAEQPAQQPY 420

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020 1001 QRQDQHHQSAMMHPASAAGPPIVATPpaystqyvaysPQQFPNQPLVQHVPHYQSQHPHVySPVIQgnarmmaPPTHAQP 1080
Cdd:PRK10263   421 YAPAPEQPAQQPYYAPAPEQPVAGNA-----------WQAEEQQSTFAPQSTYQTEQTYQ-QPAAQ-------EPLYQQP 481

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020 1081 GLVsssatqygahEQTHAMYACPKLPYNKETSPSFYFaisTGSLAQQYAHPNATLHP-HTPHPQPSATPTGQQQSQHGGS 1159
Cdd:PRK10263   482 QPV----------EQQPVVEPEPVVEETKPARPPLYY---FEEVEEKRAREREQLAAwYQPIPEPVKEPEPIKSSLKAPS 548

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1333701020 1160 HPAPSPVQHHQHQAAQALHLaspqqQSAIYHAGLAPTP--PSMTPASN-TQSPQ 1210
Cdd:PRK10263   549 VAAVPPVEAAAAVSPLASGV-----KKATLATGAAATVaaPVFSLANSgGPRPQ 597
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 923-1163 2.13e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 45.80  E-value: 2.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020  923 QPKPSTTPTSPRPQAQPSPSMVGHQQPTPVYTQPVCFA-PNMMYPVPVSP--------GVQPLYPIPMTPMPVNQAKTYR 993
Cdd:pfam09770  106 QPAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRTGyEKYKEPEPIPDlqvdaslwGVAPKKAAAPAPAPQPAAQPAS 185

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020  994 AVPNMPQQRQDQHHQSAMM---HPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPhvysPVIQGNAR 1070
Cdd:pfam09770  186 LPAPSRKMMSLEEVEAAMRaqaKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQP----QQHPGQGH 261

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020 1071 MMAPPTHAQPGLVSSSATQYGAHEQTHAMYACPKLPynketSPSfyfaistgslaQQYAHPN------ATLHPHTPHPQP 1144
Cdd:pfam09770  262 PVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPV-----QPT-----------QILQNPNrlsaarVGYPQNPQPGVQ 325

                          250
                   ....*....|....*....
gi 1333701020 1145 SATPTGQQQSQHGGSHPAP 1163
Cdd:pfam09770  326 PAPAHQAHRQQGSFGRQAP 344
PHA03378 PHA03378
EBNA-3B; Provisional
 907-1260 2.44e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 45.44  E-value: 2.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020  907 STLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPTPVytQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPV 986
Cdd:PHA03378   583 SQLASSAPSYAQTPWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPL--RPIPMRPLRMQPITFNVLVFPTPHQPPQVEIT 660

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020  987 NQAKTYRAVPNMPQQRQDQHHqsAMMHPASAAgPPIVATPPAYSTQYvaySPQQFPNQPlvqhvphyqSQHPHvyspviq 1066
Cdd:PHA03378   661 PYKPTWTQIGHIPYQPSPTGA--NTMLPIQWA-PGTMQPPPRAPTPM---RPPAAPPGR---------AQRPA------- 718

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020 1067 gNARMMAPPTHAQPGLVSSSATQYGAHEQTHAMYACPKLPYNKETspsfyfaistgslaqQYAHPNATLHPHTPHPQPSA 1146
Cdd:PHA03378   719 -AATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPG---------------RARPPAAAPGAPTPQPPPQA 782

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020 1147 TPTGQQQSQHGgshPAPSPVQHHQHQAAQALHLASPQQQSAIYH----------------------------AGLAPTPP 1198
Cdd:PHA03378   783 PPAPQQRPRGA---PTPQPPPQAGPTSMQLMPRAAPGQQGPTKQilrqlltggvkrgrpslkkpaalerqaaAGPTPSPG 859

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1333701020 1199 SMTPASNTQSPQNSFPAAQqtvftihPSHV--QPAYTNPPHMAHVPQAHVQ-----SGMVPSHPTAHAP 1260
Cdd:PHA03378   860 SGTSDKIVQAPVFYPPVLQ-------PIQVmrQLGSVRAAAASTVTQAPTEytgerRGVGPMHPTDIPP 921
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 905-1061 2.58e-04

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 45.18  E-value: 2.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020  905 RKSTLNpnaKEFNPRSFSQPKPSTTptSPRPQAQPSPSMVGHQQPTPVYTQPVCFAPNMMYPVPVSPGVQ--PLYPIPMT 982
Cdd:TIGR01628  367 RRAHLQ---DQFMQLQPRMRQLPMG--SPMGGAMGQPPYYGQGPQQQFNGQPLGWPRMSMMPTPMGPGGPlrPNGLAPMN 441

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020  983 PMpvnqaktyRAVPNMPQQRQDQHHQSAMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQ------ 1056
Cdd:TIGR01628  442 AV--------RAPSRNAQNAAQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVLASATPQMQKQvlgerl 513


                   ....*
gi 1333701020 1057 HPHVY 1061
Cdd:TIGR01628  514 FPLVE 518
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 866-1236 1.70e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.83  E-value: 1.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020  866 NTEHKRGPEVTSQGVQTSSPGCKQEKDDKEEKKDAAEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVG 945
Cdd:pfam03154  127 NDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSV 206

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020  946 HQQPTPVYTQPVCFAPNMMYPV-------------------PVSPGVQPLYPIPMTPMPVNQAKTYRAVPNMPQQRQDQh 1006
Cdd:pfam03154  207 PPQGSPATSQPPNQTQSTAAPHtliqqtptlhpqrlpsphpPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTG- 285

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020 1007 hQSAMMHPASAAGPPIVAT------PPAYSTQyVAYSPQQFPNQPLVQhvPHYQSQHPHVYSPVIQGNARM---MAPPTH 1077
Cdd:pfam03154  286 -PSHMQHPVPPQPFPLTPQssqsqvPPGPSPA-APGQSQQRIHTPPSQ--SQLQSQQPPREQPLPPAPLSMphiKPPPTT 361

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020 1078 AQPGLVSSSATQYGAHEQTHAMYacpKLPYNKETSPSFYFAISTGSLAQQYAHPNA-TLHPHT-PHPQPSATPTGQQQSQ 1155
Cdd:pfam03154  362 PIPQLPNPQSHKHPPHLSGPSPF---QMNSNLPPPPALKPLSSLSTHHPPSAHPPPlQLMPQSqQLPPPPAQPPVLTQSQ 438

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020 1156 hggSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNSFPAAQQTVFTIHPSHVQPAYTNP 1235
Cdd:pfam03154  439 ---SLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLP 515


                   .
gi 1333701020 1236 P 1236
Cdd:pfam03154  516 P 516
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 1137-1290 2.02e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 2.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020 1137 PHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHL----------ASPQQQSAIYHAGLAPTPPSMTPASNT 1206
Cdd:PRK07764   610 EEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHhpkhvavpdaSDGGDGWPAKAGGAAPAAPPPAPAPAA 689

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020 1207 QSPQNSFPAAQQTVFTIHPSHVQPAYTNPPHMAHVPQA-----HVQSGMVPSHPTAHAPMMLMTT--QPPGGPQAALAQS 1279
Cdd:PRK07764   690 PAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGasapsPAADDPVPLPPEPDDPPDPAGApaQPPPPPAPAPAAA 769

                          170
                   ....*....|.
gi 1333701020 1280 ALQPIPVSTTA 1290
Cdd:PRK07764   770 PAAAPPPSPPS 780
PHA03247 PHA03247
large tegument protein UL36; Provisional
 930-1293 3.89e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 3.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020  930 PTSPRPQAQPSPSmVGHQQPTPVYTqpvcfapnmmyPVPVSPGVQPLYPIPMTPMPVNQAKTYRAVPNMPQQRQdqhhQS 1009
Cdd:PHA03247  2551 PPPPLPPAAPPAA-PDRSVPPPRPA-----------PRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPA----PP 2614

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020 1010 AMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMMAPPTHAQPGLVSSSATQ 1089
Cdd:PHA03247  2615 SPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGS 2694

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020 1090 YGAHEQTHAMyacPKLPYNKETSPSFYFAISTGSLAQQYAHPNATLHPHTP----HPQPSATPTGQQQSQHGGSHPAPSP 1165
Cdd:PHA03247  2695 LTSLADPPPP---PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPavpaGPATPGGPARPARPPTTAGPPAPAP 2771

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020 1166 VQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNSFPAAQQTVFTIHPSHVQPAYTNPPHMAHVPQAH 1245
Cdd:PHA03247  2772 PAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP 2851

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 1333701020 1246 VQSGMVPSHPTAHAPMMLMTTQPPGGPQAALAQSALQPIPVSTTAHFP 1293
Cdd:PHA03247  2852 LGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFA 2899
PAM2 pfam07145
Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various ...
 905-920 5.45e-03

Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various eukaryotic proteins as an important binding site for pfam00658. It has been found in a wide range of eukaryotic proteins. Strikingly, this motif appears to occur solely outside of globular domains.


Pssm-ID: 429316  Cd Length: 17  Bit Score: 35.28  E-value: 5.45e-03
                           10
                   ....*....|....*.
gi 1333701020  905 RKSTLNPNAKEFNPRS 920
Cdd:pfam07145    1 SKSKLNPNAKEFVPSF 16
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 970-1082 5.71e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.22  E-value: 5.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333701020  970 SPGVQPLYPiPMTPMPVNQAKTYRAVPNMPQQRQDQHHQSAMMHPASAAGPPIVATPPAYST--QYVAYSPQ-QFPNQPL 1046
Cdd:PRK10263   746 TPIVEPVQQ-PQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQpqQPVAPQPQyQQPQQPV 824

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1333701020 1047 VQHVPHYQSQHPHVYSP---------VIQGNARMMAPPTHAQPGL 1082
Cdd:PRK10263   825 APQPQYQQPQQPVAPQPqdtllhpllMRNGDSRPLHKPTTPLPSL 869
Sm_like cd00600
Sm and related proteins; The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to ...
 267-334 9.26e-03

Sm and related proteins; The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of this family share a highly conserved Sm fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta-sheet. Sm-like proteins exist in archaea as well as prokaryotes that form heptameric and hexameric ring structures similar to those found in eukaryotes.


Pssm-ID: 212462 [Multi-domain]  Cd Length: 63  Bit Score: 36.07  E-value: 9.26e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1333701020  267 LTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTEsssgpKREEIMESILFKCSDFVVVQ 334
Cdd:cd00600      1 LKDFIGKTVSVELKDGRVLTGTLVAFDKYMNLVLDDVVETGRD-----GKVRVLGLVLIRGSNIVSIR 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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