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Conserved domains on  [gi|1333666363|ref|XP_023497009|]
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ADAMTS-like protein 4 isoform X1 [Equus caballus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 507-620 2.25e-29

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


:

Pssm-ID: 461796  Cd Length: 115  Bit Score: 113.06  E-value: 2.25e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  507 LVSGNLTnRGGPLGYQKILLIPAGASRLHIAQLQPSSNYLALRGPGGRSIINGNWAVDP-PGSYTAGGTIFRYNRPPREe 585
Cdd:pfam05986    1 TVSGSFT-EGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISLnPTYPSLLGTVLEYRRSLPA- 78

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1333666363  586 gtGESLSAEGPTTQPVDVYMIFQEE---NPGVFYQYVI 620
Cdd:pfam05986   79 --LEELHAPGPTQEDLEIQVLRQYGkgtNPGITYEYFI 114
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 748-804 1.30e-15

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 71.72  E-value: 1.30e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1333666363  748 WEAGEWTSCSRSCGPGTQHRQLRCRQEfgGGGSSVPPERCGHLPRPNITQPCQLRLC 804
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQK--GGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 936-992 9.01e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 64.01  E-value: 9.01e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1333666363  936 WYTGPWTECSSECGSGTQRRDIICVSKLGteFNVTSPSNCAHLPRPPALQPCQGQDC 992
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGG--GSIVPDSECSAQKKPPETQSCNLKPC 55
ADAMTS_CR_3 super family cl41950
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 411-505 3.78e-11

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


The actual alignment was detected with superfamily member pfam19236:

Pssm-ID: 437068  Cd Length: 115  Bit Score: 61.26  E-value: 3.78e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  411 QCAAFDSQEFM-----GQLYQW-EPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQP------GALDICVAGRCL 478
Cdd:pfam19236    9 QCARTDGQPLRsspggASFYHWgAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPsgpredGTLSLCVLGSCR 88

                           90       100
                   ....*....|....*....|....*..
gi 1333666363  479 SPGCDGILGSGRRRDGCGVCGGDDSTC 505
Cdd:pfam19236   89 TFGCDGRMDSQQVWDRCQVCGGDNSTC 115
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 1055-1084 1.95e-10

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


:

Pssm-ID: 462560  Cd Length: 31  Bit Score: 56.39  E-value: 1.95e-10
                           10        20        30
                   ....*....|....*....|....*....|
gi 1333666363 1055 CKDSSPHCPLVVQARLCVYPYYTATCCRSC 1084
Cdd:pfam08686    1 CKDKFANCSLVVQARLCSHKYYRQFCCRSC 30
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 866-930 7.64e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.84  E-value: 7.64e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1333666363  866 WFHSDWSSkCSAECGTGIQRRSVVCLGSGEahgvgqeetGTGTSEQSCAPGSRPPDMRACSLRPC 930
Cdd:pfam19030    1 WVAGPWGE-CSVTCGGGVQTRLVQCVQKGG---------GSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 996-1047 9.57e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.46  E-value: 9.57e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1333666363  996 WFSTTWSPCSRSCQGGIQTREVQCL-TANQTLSI--RCPAHLRPSRKRPCNSQPC 1047
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqKGGGSIVPdsECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 812-862 1.07e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.46  E-value: 1.07e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1333666363  812 PWSQCSVRCGRGQRSRQVRCVGNNGDEVSERECASGPPRPPNREACDMGPC 862
Cdd:pfam19030    5 PWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
dnaA super family cl42516
chromosomal replication initiator protein DnaA;
208-353 2.68e-05

chromosomal replication initiator protein DnaA;


The actual alignment was detected with superfamily member PRK14086:

Pssm-ID: 455861 [Multi-domain]  Cd Length: 617  Bit Score: 48.28  E-value: 2.68e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  208 ELSQASDLPSLTPRAEPSSANHTPQTQLPPTELSAHTPSPPAEPQSPEmAQTEVPSRTRPDPTWPHPRAQAS-STEPPSS 286
Cdd:PRK14086    94 EPAPPPPHARRTSEPELPRPGRRPYEGYGGPRADDRPPGLPRQDQLPT-ARPAYPAYQQRPEPGAWPRAADDyGWQQQRL 172

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1333666363  287 IFSPGESssfHVSPQPGMPSSQGWASPRVTERypnPFLSVPWGRGQQSREHWRPGGHLHRSLTEPAP 353
Cdd:PRK14086   173 GFPPRAP---YASPASYAPEQERDREPYDAGR---PEYDQRRRDYDHPRPDWDRPRRDRTDRPEPPP 233
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 73-103 1.22e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 40.65  E-value: 1.22e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1333666363    73 WGPWDQWASCSQPCGVGVQRRIRTCQLPTDQ 103
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQ 31
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 695-744 1.98e-04

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 40.13  E-value: 1.98e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1333666363  695 SECSASCGKGVWRPVFLCISRESGEELDERSCALGARPPASlEPCHGPPC 744
Cdd:pfam19030    7 GECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPET-QSCNLKPC 55
PRK07764 super family cl35613
DNA polymerase III subunits gamma and tau; Validated
 122-286 1.28e-03

DNA polymerase III subunits gamma and tau; Validated


The actual alignment was detected with superfamily member PRK07764:

Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.05  E-value: 1.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  122 LPGGQGPRPQTSRATLPLYRPQPRGTSGPLGGPVSQLGREEAQEIQGARRSRVRDPIKPGMFGYGRVPFALPLHRNRRHP 201
Cdd:PRK07764   607 GPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPA 686

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  202 RRSPRSELSQASDLPSLTPRAEPSSANHT---------PQTQLPPTELSAHTPSPPAEPQSPEmaQTEVPSRTRPDPTWP 272
Cdd:PRK07764   687 PAAPAAPAGAAPAQPAPAPAATPPAGQADdpaaqppqaAQGASAPSPAADDPVPLPPEPDDPP--DPAGAPAQPPPPPAP 764

                          170
                   ....*....|....
gi 1333666363  273 HPRAQASSTEPPSS 286
Cdd:PRK07764   765 APAAAPAAAPPPSP 778
 
Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 507-620 2.25e-29

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 113.06  E-value: 2.25e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  507 LVSGNLTnRGGPLGYQKILLIPAGASRLHIAQLQPSSNYLALRGPGGRSIINGNWAVDP-PGSYTAGGTIFRYNRPPREe 585
Cdd:pfam05986    1 TVSGSFT-EGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISLnPTYPSLLGTVLEYRRSLPA- 78

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1333666363  586 gtGESLSAEGPTTQPVDVYMIFQEE---NPGVFYQYVI 620
Cdd:pfam05986   79 --LEELHAPGPTQEDLEIQVLRQYGkgtNPGITYEYFI 114
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 748-804 1.30e-15

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 71.72  E-value: 1.30e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1333666363  748 WEAGEWTSCSRSCGPGTQHRQLRCRQEfgGGGSSVPPERCGHLPRPNITQPCQLRLC 804
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQK--GGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 936-992 9.01e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 64.01  E-value: 9.01e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1333666363  936 WYTGPWTECSSECGSGTQRRDIICVSKLGteFNVTSPSNCAHLPRPPALQPCQGQDC 992
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGG--GSIVPDSECSAQKKPPETQSCNLKPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 411-505 3.78e-11

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 61.26  E-value: 3.78e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  411 QCAAFDSQEFM-----GQLYQW-EPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQP------GALDICVAGRCL 478
Cdd:pfam19236    9 QCARTDGQPLRsspggASFYHWgAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPsgpredGTLSLCVLGSCR 88

                           90       100
                   ....*....|....*....|....*..
gi 1333666363  479 SPGCDGILGSGRRRDGCGVCGGDDSTC 505
Cdd:pfam19236   89 TFGCDGRMDSQQVWDRCQVCGGDNSTC 115
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 1055-1084 1.95e-10

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


Pssm-ID: 462560  Cd Length: 31  Bit Score: 56.39  E-value: 1.95e-10
                           10        20        30
                   ....*....|....*....|....*....|
gi 1333666363 1055 CKDSSPHCPLVVQARLCVYPYYTATCCRSC 1084
Cdd:pfam08686    1 CKDKFANCSLVVQARLCSHKYYRQFCCRSC 30
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 866-930 7.64e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.84  E-value: 7.64e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1333666363  866 WFHSDWSSkCSAECGTGIQRRSVVCLGSGEahgvgqeetGTGTSEQSCAPGSRPPDMRACSLRPC 930
Cdd:pfam19030    1 WVAGPWGE-CSVTCGGGVQTRLVQCVQKGG---------GSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 996-1047 9.57e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.46  E-value: 9.57e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1333666363  996 WFSTTWSPCSRSCQGGIQTREVQCL-TANQTLSI--RCPAHLRPSRKRPCNSQPC 1047
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqKGGGSIVPdsECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 812-862 1.07e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.46  E-value: 1.07e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1333666363  812 PWSQCSVRCGRGQRSRQVRCVGNNGDEVSERECASGPPRPPNREACDMGPC 862
Cdd:pfam19030    5 PWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
dnaA PRK14086
chromosomal replication initiator protein DnaA;
208-353 2.68e-05

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 48.28  E-value: 2.68e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  208 ELSQASDLPSLTPRAEPSSANHTPQTQLPPTELSAHTPSPPAEPQSPEmAQTEVPSRTRPDPTWPHPRAQAS-STEPPSS 286
Cdd:PRK14086    94 EPAPPPPHARRTSEPELPRPGRRPYEGYGGPRADDRPPGLPRQDQLPT-ARPAYPAYQQRPEPGAWPRAADDyGWQQQRL 172

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1333666363  287 IFSPGESssfHVSPQPGMPSSQGWASPRVTERypnPFLSVPWGRGQQSREHWRPGGHLHRSLTEPAP 353
Cdd:PRK14086   173 GFPPRAP---YASPASYAPEQERDREPYDAGR---PEYDQRRRDYDHPRPDWDRPRRDRTDRPEPPP 233
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 73-103 1.22e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 40.65  E-value: 1.22e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1333666363    73 WGPWDQWASCSQPCGVGVQRRIRTCQLPTDQ 103
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQ 31
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 999-1048 1.29e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 40.65  E-value: 1.29e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1333666363   999 TTWSPCSRSCQGGIQTREVQCLTANQTLS-IRCPAHLRpsRKRPCNSQPCS 1048
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGgGPCTGEDV--ETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 695-744 1.98e-04

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 40.13  E-value: 1.98e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1333666363  695 SECSASCGKGVWRPVFLCISRESGEELDERSCALGARPPASlEPCHGPPC 744
Cdd:pfam19030    7 GECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPET-QSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 804-862 6.43e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.72  E-value: 6.43e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1333666363   804 CGHWevrSPWSQCSVRCGRGQRSRQVRCVGNNGDeVSERECasgPPRPPNREACDMGPC 862
Cdd:smart00209    1 WSEW---SEWSPCSVTCGGGVQTRTRSCCSPPPQ-NGGGPC---TGEDVETRACNEQPC 52
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 122-286 1.28e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.05  E-value: 1.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  122 LPGGQGPRPQTSRATLPLYRPQPRGTSGPLGGPVSQLGREEAQEIQGARRSRVRDPIKPGMFGYGRVPFALPLHRNRRHP 201
Cdd:PRK07764   607 GPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPA 686

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  202 RRSPRSELSQASDLPSLTPRAEPSSANHT---------PQTQLPPTELSAHTPSPPAEPQSPEmaQTEVPSRTRPDPTWP 272
Cdd:PRK07764   687 PAAPAAPAGAAPAQPAPAPAATPPAGQADdpaaqppqaAQGASAPSPAADDPVPLPPEPDDPP--DPAGAPAQPPPPPAP 764

                          170
                   ....*....|....
gi 1333666363  273 HPRAQASSTEPPSS 286
Cdd:PRK07764   765 APAAAPAAAPPPSP 778
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 804-859 2.60e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 41.87  E-value: 2.60e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1333666363  804 CGHWEvrsPWSQCSVRCGRGQRSRQ-----VRCVGNNGDEVSERECasgpprPPNREACDM 859
Cdd:PTZ00441   240 CGPWD---EWTPCSVTCGKGTHSRSrpilhEGCTTHMVEECEEEEC------PVEPEPLPV 291
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 748-804 4.06e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.41  E-value: 4.06e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1333666363   748 WEAGEWTSCSRSCGPGTQHRQLRCRqefgGGGSSVPPERCGHLPRpnITQPCQLRLC 804
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCC----SPPPQNGGGPCTGEDV--ETRACNEQPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
74-100 6.25e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 35.86  E-value: 6.25e-03
                           10        20
                   ....*....|....*....|....*..
gi 1333666363   74 GPWDQWASCSQPCGVGVQRRIRTCQLP 100
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSP 27
 
Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 507-620 2.25e-29

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 113.06  E-value: 2.25e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  507 LVSGNLTnRGGPLGYQKILLIPAGASRLHIAQLQPSSNYLALRGPGGRSIINGNWAVDP-PGSYTAGGTIFRYNRPPREe 585
Cdd:pfam05986    1 TVSGSFT-EGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISLnPTYPSLLGTVLEYRRSLPA- 78

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1333666363  586 gtGESLSAEGPTTQPVDVYMIFQEE---NPGVFYQYVI 620
Cdd:pfam05986   79 --LEELHAPGPTQEDLEIQVLRQYGkgtNPGITYEYFI 114
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 748-804 1.30e-15

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 71.72  E-value: 1.30e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1333666363  748 WEAGEWTSCSRSCGPGTQHRQLRCRQEfgGGGSSVPPERCGHLPRPNITQPCQLRLC 804
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQK--GGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 936-992 9.01e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 64.01  E-value: 9.01e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1333666363  936 WYTGPWTECSSECGSGTQRRDIICVSKLGteFNVTSPSNCAHLPRPPALQPCQGQDC 992
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGG--GSIVPDSECSAQKKPPETQSCNLKPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 411-505 3.78e-11

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 61.26  E-value: 3.78e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  411 QCAAFDSQEFM-----GQLYQW-EPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQP------GALDICVAGRCL 478
Cdd:pfam19236    9 QCARTDGQPLRsspggASFYHWgAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPsgpredGTLSLCVLGSCR 88

                           90       100
                   ....*....|....*....|....*..
gi 1333666363  479 SPGCDGILGSGRRRDGCGVCGGDDSTC 505
Cdd:pfam19236   89 TFGCDGRMDSQQVWDRCQVCGGDNSTC 115
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 1055-1084 1.95e-10

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


Pssm-ID: 462560  Cd Length: 31  Bit Score: 56.39  E-value: 1.95e-10
                           10        20        30
                   ....*....|....*....|....*....|
gi 1333666363 1055 CKDSSPHCPLVVQARLCVYPYYTATCCRSC 1084
Cdd:pfam08686    1 CKDKFANCSLVVQARLCSHKYYRQFCCRSC 30
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 866-930 7.64e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.84  E-value: 7.64e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1333666363  866 WFHSDWSSkCSAECGTGIQRRSVVCLGSGEahgvgqeetGTGTSEQSCAPGSRPPDMRACSLRPC 930
Cdd:pfam19030    1 WVAGPWGE-CSVTCGGGVQTRLVQCVQKGG---------GSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 996-1047 9.57e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.46  E-value: 9.57e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1333666363  996 WFSTTWSPCSRSCQGGIQTREVQCL-TANQTLSI--RCPAHLRPSRKRPCNSQPC 1047
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqKGGGSIVPdsECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 812-862 1.07e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.46  E-value: 1.07e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1333666363  812 PWSQCSVRCGRGQRSRQVRCVGNNGDEVSERECASGPPRPPNREACDMGPC 862
Cdd:pfam19030    5 PWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
dnaA PRK14086
chromosomal replication initiator protein DnaA;
208-353 2.68e-05

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 48.28  E-value: 2.68e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  208 ELSQASDLPSLTPRAEPSSANHTPQTQLPPTELSAHTPSPPAEPQSPEmAQTEVPSRTRPDPTWPHPRAQAS-STEPPSS 286
Cdd:PRK14086    94 EPAPPPPHARRTSEPELPRPGRRPYEGYGGPRADDRPPGLPRQDQLPT-ARPAYPAYQQRPEPGAWPRAADDyGWQQQRL 172

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1333666363  287 IFSPGESssfHVSPQPGMPSSQGWASPRVTERypnPFLSVPWGRGQQSREHWRPGGHLHRSLTEPAP 353
Cdd:PRK14086   173 GFPPRAP---YASPASYAPEQERDREPYDAGR---PEYDQRRRDYDHPRPDWDRPRRDRTDRPEPPP 233
PHA03247 PHA03247
large tegument protein UL36; Provisional
 123-312 3.21e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 3.21e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  123 PGGQGPRPQTSRATLPLYRPQPRGTSGPLGGPVSQLG--------REEAQEIQGARRSRVRDPIKPGMfGYGRVPFALPl 194
Cdd:PHA03247  2824 PAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGdvrrrppsRSPAAKPAAPARPPVRRLARPAV-SRSTESFALP- 2901

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  195 hrnrrhprrsprselsqasDLPSLTPRAEPSSANHTPQTQLPPTELSAHTPSPPAEPQSPEMAQTEVPSRTRPDPTWPHP 274
Cdd:PHA03247  2902 -------------------PDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQP 2962

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1333666363  275 -------------RAQASSTEPPSSIFSPgESSSFHVSPQPGMPSsqgWAS 312
Cdd:PHA03247  2963 wlgalvpgrvavpRFRVPQPAPSREAPAS-STPPLTGHSLSRVSS---WAS 3009
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 999-1047 1.00e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 41.11  E-value: 1.00e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1333666363  999 TTWSPCSRSCQGGIQTREVQCLTANQTLSIRCPAHLrpsRKRPCNSQPC 1047
Cdd:pfam19028    7 SEWSECSVTCGGGVQTRTRTVIVEPQNGGRPCPELL---ERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 73-103 1.22e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 40.65  E-value: 1.22e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1333666363    73 WGPWDQWASCSQPCGVGVQRRIRTCQLPTDQ 103
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQ 31
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 999-1048 1.29e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 40.65  E-value: 1.29e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1333666363   999 TTWSPCSRSCQGGIQTREVQCLTANQTLS-IRCPAHLRpsRKRPCNSQPCS 1048
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGgGPCTGEDV--ETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 695-744 1.98e-04

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 40.13  E-value: 1.98e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1333666363  695 SECSASCGKGVWRPVFLCISRESGEELDERSCALGARPPASlEPCHGPPC 744
Cdd:pfam19030    7 GECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPET-QSCNLKPC 55
PHA03247 PHA03247
large tegument protein UL36; Provisional
 120-409 5.88e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 5.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  120 ALLPGGQGPRPqtsRATLPLYRPQPRGTSGPLGGPVSQLGREEAQEIQGARRS--RVRDPIKPGMFGYGR---------- 187
Cdd:PHA03247  2748 PATPGGPARPA---RPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESlpSPWDPADPPAAVLAPaaalppaasp 2824

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  188 ----------VPFALPLHRNRRHPRRSPRSELSQASDL----PSLTPRAEPSSANHTPQTQLPPTELSAHT--------- 244
Cdd:PHA03247  2825 agplppptsaQPTAPPPPPGPPPPSLPLGGSVAPGGDVrrrpPSRSPAAKPAAPARPPVRRLARPAVSRSTesfalppdq 2904

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  245 PSPPAEPQSPEMAQTEVPSRTRPDPTwPHPRAQASSTEPPssifSPGESSSFHVSPQPGMPSSqgWASPRVTERYPNPFL 324
Cdd:PHA03247  2905 PERPPQPQAPPPPQPQPQPPPPPQPQ-PPPPPPPRPQPPL----APTTDPAGAGEPSGAVPQP--WLGALVPGRVAVPRF 2977

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  325 SVPWGRgqQSREHWRPGGHLHRSLTEPAPHHPAGWLPLL--SAGPHSSSLWSLFAP-----SSLVPRCSGESEQLRACIQ 397
Cdd:PHA03247  2978 RVPQPA--PSREAPASSTPPLTGHSLSRVSSWASSLALHeeTDPPPVSLKQTLWPPddtedSDADSLFDSDSERSDLEAL 3055

                          330
                   ....*....|..
gi 1333666363  398 VPCPPEQPDPRA 409
Cdd:PHA03247  3056 DPLPPEPHDPFA 3067
PHA03247 PHA03247
large tegument protein UL36; Provisional
 133-407 6.08e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 6.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  133 SRATLPLYRPQPRGTSGPLGgPVSQLGREEAQEIQGARRSRVRDPikpgmfgygrvpfALPLHRNRRHPRRSPRSELSQA 212
Cdd:PHA03247  2674 AQASSPPQRPRRRAARPTVG-SLTSLADPPPPPPTPEPAPHALVS-------------ATPLPPGPAAARQASPALPAAP 2739

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  213 SDLPSLTPRAEPSSANHTPQTQLPPTELSAHTPSPPAEPQSPEMAQTEVPSRTRPDPTWPHPRAQASSTEPPSSIFSPGE 292
Cdd:PHA03247  2740 APPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALP 2819

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  293 SSSFHVSPQPGMPSSQGWASPRVTERYPNPFLS----VPWG----RGQQSREHWRPGGHLH---RSLTEPAPHHPAGWLP 361
Cdd:PHA03247  2820 PAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLggsvAPGGdvrrRPPSRSPAAKPAAPARppvRRLARPAVSRSTESFA 2899

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 1333666363  362 LLSAGPHSSSLWSLFAPsslvPRCSGESEQLRACIQVPCPPEQPDP 407
Cdd:PHA03247  2900 LPPDQPERPPQPQAPPP----PQPQPQPPPPPQPQPPPPPPPRPQP 2941
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 804-862 6.43e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.72  E-value: 6.43e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1333666363   804 CGHWevrSPWSQCSVRCGRGQRSRQVRCVGNNGDeVSERECasgPPRPPNREACDMGPC 862
Cdd:smart00209    1 WSEW---SEWSPCSVTCGGGVQTRTRSCCSPPPQ-NGGGPC---TGEDVETRACNEQPC 52
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
216-436 7.49e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.71  E-value: 7.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  216 PSLTPRAEPSSANHTPQTQLPPTELSAHTPSPPAEPQSPEMAQTEVPSRTRPDPTWPHPRAQASSTEPPSsifSPGESSS 295
Cdd:PRK12323   377 AAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGG---APAPAPA 453

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  296 FHVSPQPGMPSSQGWASPRVTERYPNPFLSVPWGRGQQSREHWRPGGHLHRSLTEPAPHH----PAGWLPLLSAGPHSSS 371
Cdd:PRK12323   454 PAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQpdaaPAGWVAESIPDPATAD 533

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  372 LWSLF------APSSLVPRCSGESEQLRAciqvPCPPEQPDPRALQCAAFDSQEFMGQL----------YQWEpFTEVQG 435
Cdd:PRK12323   534 PDDAFetlapaPAAAPAPRAAAATEPVVA----PRPPRASASGLPDMFDGDWPALAARLpvrglaqqlaRQSE-LAGVEG 608


                   .
gi 1333666363  436 S 436
Cdd:PRK12323   609 D 609
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 122-286 1.28e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.05  E-value: 1.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  122 LPGGQGPRPQTSRATLPLYRPQPRGTSGPLGGPVSQLGREEAQEIQGARRSRVRDPIKPGMFGYGRVPFALPLHRNRRHP 201
Cdd:PRK07764   607 GPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPA 686

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  202 RRSPRSELSQASDLPSLTPRAEPSSANHT---------PQTQLPPTELSAHTPSPPAEPQSPEmaQTEVPSRTRPDPTWP 272
Cdd:PRK07764   687 PAAPAAPAGAAPAQPAPAPAATPPAGQADdpaaqppqaAQGASAPSPAADDPVPLPPEPDDPP--DPAGAPAQPPPPPAP 764

                          170
                   ....*....|....
gi 1333666363  273 HPRAQASSTEPPSS 286
Cdd:PRK07764   765 APAAAPAAAPPPSP 778
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 804-859 2.60e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 41.87  E-value: 2.60e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1333666363  804 CGHWEvrsPWSQCSVRCGRGQRSRQ-----VRCVGNNGDEVSERECasgpprPPNREACDM 859
Cdd:PTZ00441   240 CGPWD---EWTPCSVTCGKGTHSRSrpilhEGCTTHMVEECEEEEC------PVEPEPLPV 291
PHA03247 PHA03247
large tegument protein UL36; Provisional
 128-413 3.04e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 3.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  128 PRPQTSRATLPLYRPQPRgTSGPlggpvsqlgreeaqeiqgARRSRVRDPIKPGMFGYGRVPFALPLHRNRRhprrsprs 207
Cdd:PHA03247  2559 APPAAPDRSVPPPRPAPR-PSEP------------------AVTSRARRPDAPPQSARPRAPVDDRGDPRGP-------- 2611

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  208 elSQASDLPSLTPRAEPSSANHTPQTQLPPTELSAHTPSPPAEPQSPEMAQTEVPSRTRPD---------PTWPHPRAQ- 277
Cdd:PHA03247  2612 --APPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLgraaqasspPQRPRRRAAr 2689

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  278 ------ASSTEPPSSIFSPGESSSFHVS--PQPGMPSSQGWASPRVT-ERYPNPFLSVPWGRGQQSREHWRPGGHLHRSL 348
Cdd:PHA03247  2690 ptvgslTSLADPPPPPPTPEPAPHALVSatPLPPGPAAARQASPALPaAPAPPAVPAGPATPGGPARPARPPTTAGPPAP 2769

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1333666363  349 TEPA--PHHPAGWLPLLSAGPHSSSLWSLFAPSSLVPRCSGESEQLRA--CIQVPCPPEQPDPRALQCA 413
Cdd:PHA03247  2770 APPAapAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAAlpPAASPAGPLPPPTSAQPTA 2838
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 74-297 3.06e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 41.49  E-value: 3.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363   74 GPWDQWASCSQPCGVGVQRRIRtcqlptDQLHQGLPLPPRPPRLPEALLPggqGPRPQTSRATLPLY----RPQPRGTSG 149
Cdd:PTZ00441   241 GPWDEWTPCSVTCGKGTHSRSR------PILHEGCTTHMVEECEEEECPV---EPEPLPVPAPVPPTpeddNPRPTDDEF 311

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  150 PLGGPVSQLG--REEAQEIQGARRSRVRDPIKPGMFGYG--RVPFALPLHRNRRHPRRSPRSELSQASDLPsltpraePS 225
Cdd:PTZ00441   312 AVPNFNEGLDvpDNPQDPVPPPNEGKDGNPNEENLFPPGddEVPDESNVPPNPPNVPGGSNSEFSSDVENP-------PN 384

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  226 SANHTPQTQLPPTELSAHTPSPPAEPQSPEMAQTE---VPSRTR------PDPTWPHPRAQASSTEPPSSIFSPGESSSF 296
Cdd:PTZ00441   385 PPNPDIPEQEPNIPEDSNKEVPEDVPMEPEDDRDNnfnEPKKPEnkgdgqNEPVIPKPLDNERDQSNKNKQVNPGNRHNS 464


                   .
gi 1333666363  297 H 297
Cdd:PTZ00441   465 E 465
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 748-804 4.06e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.41  E-value: 4.06e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1333666363   748 WEAGEWTSCSRSCGPGTQHRQLRCRqefgGGGSSVPPERCGHLPRpnITQPCQLRLC 804
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCC----SPPPQNGGGPCTGEDV--ETRACNEQPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
74-100 6.25e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 35.86  E-value: 6.25e-03
                           10        20
                   ....*....|....*....|....*..
gi 1333666363   74 GPWDQWASCSQPCGVGVQRRIRTCQLP 100
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSP 27
TSP_1 pfam00090
Thrombospondin type 1 domain;
811-834 7.31e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 35.47  E-value: 7.31e-03
                           10        20
                   ....*....|....*....|....
gi 1333666363  811 SPWSQCSVRCGRGQRSRQVRCVGN 834
Cdd:pfam00090    4 SPWSPCSVTCGKGIQVRQRTCKSP 27
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 219-314 8.91e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.08  E-value: 8.91e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333666363  219 TPRAEPSSANHTPQTQLPPTELSAHTPSPPAEPQSPemAQTEVPSRTRPDPTwPHPRAQASSTEPPSSIFSPGESSSF-- 296
Cdd:PRK14951   388 APAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPP--APVAAPAAAAPAAA-PAAAPAAVALAPAPPAQAAPETVAIpv 464

                           90
                   ....*....|....*...
gi 1333666363  297 HVSPQPGMPSSQGWASPR 314
Cdd:PRK14951   465 RVAPEPAVASAAPAPAAA 482
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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