|
Name |
Accession |
Description |
Interval |
E-value |
| SM-ATX |
pfam14438 |
Ataxin 2 SM domain; This SM domain is found in Ataxin-2. |
262-335 |
5.13e-21 |
|
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
:
Pssm-ID: 464173 Cd Length: 78 Bit Score: 88.38 E-value: 5.13e-21
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1777350999 262 MVHILTSVVGSKCEVQVKNGGIYEGVFKTYSP--KCDLVLDAAHEKSTESSSG--PKREEIMESILFKCSDFVVVQFK 335
Cdd:pfam14438 1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASLekDFGVVLKMARRIKKSNGSGlnPVRGEIVDTMIFPAKDIVDIEAK 78
|
|
| LsmAD |
pfam06741 |
LsmAD domain; This domain is found associated with Lsm domain. |
403-464 |
9.72e-16 |
|
LsmAD domain; This domain is found associated with Lsm domain.
:
Pssm-ID: 461998 [Multi-domain] Cd Length: 65 Bit Score: 72.60 E-value: 9.72e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1777350999 403 YGVVSTYDSSLssYTVPLERdNSEEFLKREARANQLAEEIESSAQYKARVALENDDR------SEEEK 464
Cdd:pfam06741 1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERGLDvddsglDEEDK 65
|
|
| PAT1 super family |
cl37801 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
924-1112 |
9.39e-07 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
The actual alignment was detected with superfamily member pfam09770:
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 53.50 E-value: 9.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 924 KPSTTPTSPRPQAQPSPSMVGHQ--------------QPTPVYTQPvcfaPNMMYPVPVSPGVQPLYPIPMTPMPVNQAK 989
Cdd:pfam09770 169 KAAAPAPAPQPAAQPASLPAPSRkmmsleeveaamraQAKKPAQQP----APAPAQPPAAPPAQQAQQQQQFPPQIQQQQ 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 990 TYRAVPNMPQQRQDQHHQ-SAMMHPASAAGPPiaaTPPAYSTQyvaySPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNA 1068
Cdd:pfam09770 245 QPQQQPQQPQQHPGQGHPvTILQRPQSPQPDP---AQPSIQPQ----AQQFHQQPPPVPVQPTQILQNPNRLSAARVGYP 317
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1777350999 1069 RMMAPPTHAQPGlvsssatqygahEQTHAMYVSTGSLAQQYAHP 1112
Cdd:pfam09770 318 QNPQPGVQPAPA------------HQAHRQQGSFGRQAPIITHP 349
|
|
| PRK12323 super family |
cl46901 |
DNA polymerase III subunit gamma/tau; |
562-753 |
1.68e-03 |
|
DNA polymerase III subunit gamma/tau;
The actual alignment was detected with superfamily member PRK12323:
Pssm-ID: 481241 [Multi-domain] Cd Length: 700 Bit Score: 42.56 E-value: 1.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 562 QSGPNSLPPRAAT----PTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSI 637
Cdd:PRK12323 367 QSGGGAGPATAAAapvaQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGG 446
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 638 SSGLEFVSHNPPSEAATPPVARTSPSGGTWSSV-VSGVPRLSPKTHRPRSPRQNSIGNTPSGPVLASPQAGIIPTEAVAM 716
Cdd:PRK12323 447 APAPAPAPAAAPAAAARPAAAGPRPVAAAAAAApARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESI 526
|
170 180 190
....*....|....*....|....*....|....*..
gi 1777350999 717 PIPAASPTPASPASNRAVTPSSEAKDSRLQDQRQNSP 753
Cdd:PRK12323 527 PDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAP 563
|
|
| PAM2 |
pfam07145 |
Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various ... |
904-919 |
8.18e-03 |
|
Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various eukaryotic proteins as an important binding site for pfam00658. It has been found in a wide range of eukaryotic proteins. Strikingly, this motif appears to occur solely outside of globular domains.
:
Pssm-ID: 429316 Cd Length: 17 Bit Score: 34.89 E-value: 8.18e-03
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| SM-ATX |
pfam14438 |
Ataxin 2 SM domain; This SM domain is found in Ataxin-2. |
262-335 |
5.13e-21 |
|
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
Pssm-ID: 464173 Cd Length: 78 Bit Score: 88.38 E-value: 5.13e-21
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1777350999 262 MVHILTSVVGSKCEVQVKNGGIYEGVFKTYSP--KCDLVLDAAHEKSTESSSG--PKREEIMESILFKCSDFVVVQFK 335
Cdd:pfam14438 1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASLekDFGVVLKMARRIKKSNGSGlnPVRGEIVDTMIFPAKDIVDIEAK 78
|
|
| LsmAD |
pfam06741 |
LsmAD domain; This domain is found associated with Lsm domain. |
403-464 |
9.72e-16 |
|
LsmAD domain; This domain is found associated with Lsm domain.
Pssm-ID: 461998 [Multi-domain] Cd Length: 65 Bit Score: 72.60 E-value: 9.72e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1777350999 403 YGVVSTYDSSLssYTVPLERdNSEEFLKREARANQLAEEIESSAQYKARVALENDDR------SEEEK 464
Cdd:pfam06741 1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERGLDvddsglDEEDK 65
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
924-1112 |
9.39e-07 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 53.50 E-value: 9.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 924 KPSTTPTSPRPQAQPSPSMVGHQ--------------QPTPVYTQPvcfaPNMMYPVPVSPGVQPLYPIPMTPMPVNQAK 989
Cdd:pfam09770 169 KAAAPAPAPQPAAQPASLPAPSRkmmsleeveaamraQAKKPAQQP----APAPAQPPAAPPAQQAQQQQQFPPQIQQQQ 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 990 TYRAVPNMPQQRQDQHHQ-SAMMHPASAAGPPiaaTPPAYSTQyvaySPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNA 1068
Cdd:pfam09770 245 QPQQQPQQPQQHPGQGHPvTILQRPQSPQPDP---AQPSIQPQ----AQQFHQQPPPVPVQPTQILQNPNRLSAARVGYP 317
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1777350999 1069 RMMAPPTHAQPGlvsssatqygahEQTHAMYVSTGSLAQQYAHP 1112
Cdd:pfam09770 318 QNPQPGVQPAPA------------HQAHRQQGSFGRQAPIITHP 349
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
923-1221 |
1.18e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.94 E-value: 1.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 923 PKPSTTPTSPRPQAQPSP--SMVGHQQPTPVYTQPVCFAPNMMYPVPVSPGVQ------PLYPIPMTPMPVNQAKTYRAV 994
Cdd:PHA03247 2674 AQASSPPQRPRRRAARPTvgSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAaarqasPALPAAPAPPAVPAGPATPGG 2753
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 995 PNMPQQRQDQHHQSAMMHPAS-AAGPPIAATPPAYSTQYVAYSPQQFPNQPLVQHVPhyqSQHPHVYSPVIQGNARMMAP 1073
Cdd:PHA03247 2754 PARPARPPTTAGPPAPAPPAApAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPAGPLPP 2830
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 1074 PTHAQPGLVSSSATQYGAHEQTHAMYVSTGSLA------QQYAHPNATLHPH---------------------------T 1120
Cdd:PHA03247 2831 PTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRrrppsrSPAAKPAAPARPPvrrlarpavsrstesfalppdqperppQ 2910
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 1121 PHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNSfpaaqqt 1200
Cdd:PHA03247 2911 PQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA------- 2983
|
330 340
....*....|....*....|.
gi 1777350999 1201 vftihPSHVQPAYTNPPHMAH 1221
Cdd:PHA03247 2984 -----PSREAPASSTPPLTGH 2999
|
|
| PABP-1234 |
TIGR01628 |
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ... |
931-1044 |
6.30e-05 |
|
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.
Pssm-ID: 130689 [Multi-domain] Cd Length: 562 Bit Score: 47.11 E-value: 6.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 931 SPRPQAQPSPS-MVGHQQPTPVYTQpvcfAPNMMYP-VPVSPGVQPLYPIPMTPMPVNQAKTYravPNMPQQRQDQHHQS 1008
Cdd:TIGR01628 379 QPRMRQLPMGSpMGGAMGQPPYYGQ----GPQQQFNgQPLGWPRMSMMPTPMGPGGPLRPNGL---APMNAVRAPSRNAQ 451
|
90 100 110
....*....|....*....|....*....|....*.
gi 1777350999 1009 AMMHPASAagPPIAATPPAYSTQyvaySPQQFPNQP 1044
Cdd:TIGR01628 452 NAAQKPPM--QPVMYPPNYQSLP----LSQDLPQPQ 481
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
562-753 |
1.68e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 42.56 E-value: 1.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 562 QSGPNSLPPRAAT----PTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSI 637
Cdd:PRK12323 367 QSGGGAGPATAAAapvaQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGG 446
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 638 SSGLEFVSHNPPSEAATPPVARTSPSGGTWSSV-VSGVPRLSPKTHRPRSPRQNSIGNTPSGPVLASPQAGIIPTEAVAM 716
Cdd:PRK12323 447 APAPAPAPAAAPAAAARPAAAGPRPVAAAAAAApARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESI 526
|
170 180 190
....*....|....*....|....*....|....*..
gi 1777350999 717 PIPAASPTPASPASNRAVTPSSEAKDSRLQDQRQNSP 753
Cdd:PRK12323 527 PDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAP 563
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
654-1101 |
6.55e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 41.08 E-value: 6.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 654 TPPVARTSPSGGTWSSVVSGVPRLSP-------KTHRPRSPRQNSIGNTP---SGPVLASPQAGIIPTEAVAMPIPAASP 723
Cdd:PHA03247 2552 PPPLPPAAPPAAPDRSVPPPRPAPRPsepavtsRARRPDAPPQSARPRAPvddRGDPRGPAPPSPLPPDTHAPDPPPPSP 2631
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 724 TPAS---PASNRAVTPSSEAKDSRLQDQRQNSPAGNKENIKPNETSPSFSKAENKGISPIVSEHRKQIDDLKKFKNDfRL 800
Cdd:PHA03247 2632 SPAAnepDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTP-EP 2710
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 801 QPSSTSESMDQLLNKNREAEKSRDLIKDKIEPSAKDS----FTENSSSNCTSGSSKPNSPSISPSILSNTEHKRGPEVTS 876
Cdd:PHA03247 2711 APHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGpatpGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVAS 2790
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 877 QGVQTSSpackQEKDDKEEKKDAAEQVRKSTLNPNAKefnPRSFSQPKPSTTPTSPRPQAQPSPSMVG-----------H 945
Cdd:PHA03247 2791 LSESRES----LPSPWDPADPPAAVLAPAAALPPAAS---PAGPLPPPTSAQPTAPPPPPGPPPPSLPlggsvapggdvR 2863
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 946 QQPTPVYTQPVCFAPNMMY-------PVPVSPGVQPLYPIPMTPMPVNQAKTY-RAVPNMPQQRQDQHHQSAMMHPASAA 1017
Cdd:PHA03247 2864 RRPPSRSPAAKPAAPARPPvrrlarpAVSRSTESFALPPDQPERPPQPQAPPPpQPQPQPPPPPQPQPPPPPPPRPQPPL 2943
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 1018 gPPIAATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPhvySPVIQGNARMMAPPTHAQPGLVSSSATQYGAHEQTHA 1097
Cdd:PHA03247 2944 -APTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQP---APSREAPASSTPPLTGHSLSRVSSWASSLALHEETDP 3019
|
....
gi 1777350999 1098 MYVS 1101
Cdd:PHA03247 3020 PPVS 3023
|
|
| PAM2 |
pfam07145 |
Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various ... |
904-919 |
8.18e-03 |
|
Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various eukaryotic proteins as an important binding site for pfam00658. It has been found in a wide range of eukaryotic proteins. Strikingly, this motif appears to occur solely outside of globular domains.
Pssm-ID: 429316 Cd Length: 17 Bit Score: 34.89 E-value: 8.18e-03
|
| Sm_like |
cd00600 |
Sm and related proteins; The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to ... |
266-333 |
9.12e-03 |
|
Sm and related proteins; The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of this family share a highly conserved Sm fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta-sheet. Sm-like proteins exist in archaea as well as prokaryotes that form heptameric and hexameric ring structures similar to those found in eukaryotes.
Pssm-ID: 212462 [Multi-domain] Cd Length: 63 Bit Score: 36.07 E-value: 9.12e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1777350999 266 LTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTEsssgpKREEIMESILFKCSDFVVVQ 333
Cdd:cd00600 1 LKDFIGKTVSVELKDGRVLTGTLVAFDKYMNLVLDDVVETGRD-----GKVRVLGLVLIRGSNIVSIR 63
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| SM-ATX |
pfam14438 |
Ataxin 2 SM domain; This SM domain is found in Ataxin-2. |
262-335 |
5.13e-21 |
|
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
Pssm-ID: 464173 Cd Length: 78 Bit Score: 88.38 E-value: 5.13e-21
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1777350999 262 MVHILTSVVGSKCEVQVKNGGIYEGVFKTYSP--KCDLVLDAAHEKSTESSSG--PKREEIMESILFKCSDFVVVQFK 335
Cdd:pfam14438 1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASLekDFGVVLKMARRIKKSNGSGlnPVRGEIVDTMIFPAKDIVDIEAK 78
|
|
| LsmAD |
pfam06741 |
LsmAD domain; This domain is found associated with Lsm domain. |
403-464 |
9.72e-16 |
|
LsmAD domain; This domain is found associated with Lsm domain.
Pssm-ID: 461998 [Multi-domain] Cd Length: 65 Bit Score: 72.60 E-value: 9.72e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1777350999 403 YGVVSTYDSSLssYTVPLERdNSEEFLKREARANQLAEEIESSAQYKARVALENDDR------SEEEK 464
Cdd:pfam06741 1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERGLDvddsglDEEDK 65
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
924-1112 |
9.39e-07 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 53.50 E-value: 9.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 924 KPSTTPTSPRPQAQPSPSMVGHQ--------------QPTPVYTQPvcfaPNMMYPVPVSPGVQPLYPIPMTPMPVNQAK 989
Cdd:pfam09770 169 KAAAPAPAPQPAAQPASLPAPSRkmmsleeveaamraQAKKPAQQP----APAPAQPPAAPPAQQAQQQQQFPPQIQQQQ 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 990 TYRAVPNMPQQRQDQHHQ-SAMMHPASAAGPPiaaTPPAYSTQyvaySPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNA 1068
Cdd:pfam09770 245 QPQQQPQQPQQHPGQGHPvTILQRPQSPQPDP---AQPSIQPQ----AQQFHQQPPPVPVQPTQILQNPNRLSAARVGYP 317
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1777350999 1069 RMMAPPTHAQPGlvsssatqygahEQTHAMYVSTGSLAQQYAHP 1112
Cdd:pfam09770 318 QNPQPGVQPAPA------------HQAHRQQGSFGRQAPIITHP 349
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
923-1221 |
1.18e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.94 E-value: 1.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 923 PKPSTTPTSPRPQAQPSP--SMVGHQQPTPVYTQPVCFAPNMMYPVPVSPGVQ------PLYPIPMTPMPVNQAKTYRAV 994
Cdd:PHA03247 2674 AQASSPPQRPRRRAARPTvgSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAaarqasPALPAAPAPPAVPAGPATPGG 2753
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 995 PNMPQQRQDQHHQSAMMHPAS-AAGPPIAATPPAYSTQYVAYSPQQFPNQPLVQHVPhyqSQHPHVYSPVIQGNARMMAP 1073
Cdd:PHA03247 2754 PARPARPPTTAGPPAPAPPAApAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPAGPLPP 2830
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 1074 PTHAQPGLVSSSATQYGAHEQTHAMYVSTGSLA------QQYAHPNATLHPH---------------------------T 1120
Cdd:PHA03247 2831 PTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRrrppsrSPAAKPAAPARPPvrrlarpavsrstesfalppdqperppQ 2910
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 1121 PHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNSfpaaqqt 1200
Cdd:PHA03247 2911 PQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA------- 2983
|
330 340
....*....|....*....|.
gi 1777350999 1201 vftihPSHVQPAYTNPPHMAH 1221
Cdd:PHA03247 2984 -----PSREAPASSTPPLTGH 2999
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
922-1147 |
1.27e-05 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 49.65 E-value: 1.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 922 QPKPSTTPTSPRPQAQPSPSMVGHQQPTPVYTQPVCFA-PNMMYPVPVSP--------GVQPLYPIPMTPMPVNQAKTYR 992
Cdd:pfam09770 106 QPAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRTGyEKYKEPEPIPDlqvdaslwGVAPKKAAAPAPAPQPAAQPAS 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 993 AVPNMPQQRQDQHHQSAMM---HPASAAGPPIAATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPhvysPVIQGNAR 1069
Cdd:pfam09770 186 LPAPSRKMMSLEEVEAAMRaqaKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQP----QQHPGQGH 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 1070 MMA-----PPTHAQPGLVSSSATQYGAHEQTHAMYVSTGSLAQQYAHPNATLHPHTPHPQPSATPT-GQQQSQHGGSHPA 1143
Cdd:pfam09770 262 PVTilqrpQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQPGVQPApAHQAHRQQGSFGR 341
|
....
gi 1777350999 1144 PSPV 1147
Cdd:pfam09770 342 QAPI 345
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
924-1266 |
1.80e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.55 E-value: 1.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 924 KPSTTPTSPRPQAQPSPSMVGHQQPTPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAVPNMPQQRQd 1003
Cdd:PHA03247 2588 RPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRR- 2666
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 1004 qhhQSAMMHPASAAGPPIAATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMMAPPTHAQPGLVS 1083
Cdd:PHA03247 2667 ---ARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPA 2743
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 1084 SSATQYGAHEQTHAMYVSTGSLAQQYAHPNAtlhPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASP 1163
Cdd:PHA03247 2744 VPAGPATPGGPARPARPPTTAGPPAPAPPAA---PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPP 2820
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 1164 QQQSaiyhAGLAPTPPSMTPASnTQSPQNSFPAAQQTVFTIHP----SHVQPAYTNPPHMAHVPQAHVQSGMVPSHPTAH 1239
Cdd:PHA03247 2821 AASP----AGPLPPPTSAQPTA-PPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRST 2895
|
330 340
....*....|....*....|....*..
gi 1777350999 1240 APMMLMTTQPPGGPQAALAQSALQPIP 1266
Cdd:PHA03247 2896 ESFALPPDQPERPPQPQAPPPPQPQPQ 2922
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
917-1271 |
3.90e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 48.06 E-value: 3.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 917 PRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPTPvytqpvcfAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAVPN 996
Cdd:PRK07764 400 SAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAP--------APAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPA 471
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 997 MPQQRQDQHHQSAMMHPASAAGPPIAATPPAYSTQYVAYSPQQFPNQpLVQHVPHYQ-------SQHPHVYSpvIQGNAR 1069
Cdd:PRK07764 472 AAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATLRERWPE-ILAAVPKRSrktwailLPEATVLG--VRGDTL 548
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 1070 MMApptHAQPGLVSSSATQYGA-------HEQTHA-----MYVSTGSLAQQYAHPNA----TLHPHTPHPQPSATPTGQQ 1133
Cdd:PRK07764 549 VLG---FSTGGLARRFASPGNAevlvtalAEELGGdwqveAVVGPAPGAAGGEGPPApassGPPEEAARPAAPAAPAAPA 625
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 1134 QSQHGGSHPAPSPVQHHQHQAAQALHL----------ASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNSFPAAQQTVFT 1203
Cdd:PRK07764 626 APAPAGAAAAPAEASAAPAPGVAAPEHhpkhvavpdaSDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAP 705
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1777350999 1204 IHPSHVQPAYTNPPHMAHVPQA-----HVQSGMVPSHPTAHAPMMLMTT--QPPGGPQAALAQSALQPIPVSTTA 1271
Cdd:PRK07764 706 AATPPAGQADDPAAQPPQAAQGasapsPAADDPVPLPPEPDDPPDPAGApaQPPPPPAPAPAAAPAAAPPPSPPS 780
|
|
| PABP-1234 |
TIGR01628 |
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ... |
931-1044 |
6.30e-05 |
|
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.
Pssm-ID: 130689 [Multi-domain] Cd Length: 562 Bit Score: 47.11 E-value: 6.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 931 SPRPQAQPSPS-MVGHQQPTPVYTQpvcfAPNMMYP-VPVSPGVQPLYPIPMTPMPVNQAKTYravPNMPQQRQDQHHQS 1008
Cdd:TIGR01628 379 QPRMRQLPMGSpMGGAMGQPPYYGQ----GPQQQFNgQPLGWPRMSMMPTPMGPGGPLRPNGL---APMNAVRAPSRNAQ 451
|
90 100 110
....*....|....*....|....*....|....*.
gi 1777350999 1009 AMMHPASAagPPIAATPPAYSTQyvaySPQQFPNQP 1044
Cdd:TIGR01628 452 NAAQKPPM--QPVMYPPNYQSLP----LSQDLPQPQ 481
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
1012-1248 |
6.38e-05 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 47.34 E-value: 6.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 1012 HPASAAGPPIAATPPAYSTQY-VAYSPQQFPNQPLVQHVPHYQSQHP----HVySPVIQGNA--RMMAPPTHAQPGLVSS 1084
Cdd:pfam09770 106 QPAARAAQSSAQPPASSLPQYqYASQQSQQPSKPVRTGYEKYKEPEPipdlQV-DASLWGVApkKAAAPAPAPQPAAQPA 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 1085 SATQYG----------------AHEQTHAMYVSTGSLAQQYAHPNATLHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQ 1148
Cdd:pfam09770 185 SLPAPSrkmmsleeveaamraqAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVT 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 1149 HHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPqNSFPAAQQTVFTIHPSHVQPAytnPPHMAHvPQAHVQ 1228
Cdd:pfam09770 265 ILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNP-NRLSAARVGYPQNPQPGVQPA---PAHQAH-RQQGSF 339
|
250 260
....*....|....*....|
gi 1777350999 1229 SGMVPSHpTAHAPMMLMTTQ 1248
Cdd:pfam09770 340 GRQAPII-THPQQLAQLSEE 358
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
921-1062 |
3.26e-04 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 45.08 E-value: 3.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 921 SQPKPSTTPTSPRPQAQPSPsmvGHQQPTPVYT-QPVCFAPNMMYPVPVSPGVQPLYPiPMTPMPVNQAKTYRAVPNMPQ 999
Cdd:PRK10263 345 PVASVDVPPAQPTVAWQPVP---GPQTGEPVIApAPEGYPQQSQYAQPAVQYNEPLQQ-PVQPQQPYYAPAAEQPAQQPY 420
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1777350999 1000 QRQDQHHQSAMMHPASAAGPPIAATPPAYSTQYVAYSPQ--QFPNQPLVQHVPHYQSQHPHVYSP 1062
Cdd:PRK10263 421 YAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQstYQTEQTYQQPAAQEPLYQQPQPVE 485
|
|
| PABP-1234 |
TIGR01628 |
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ... |
904-1060 |
6.27e-04 |
|
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.
Pssm-ID: 130689 [Multi-domain] Cd Length: 562 Bit Score: 44.03 E-value: 6.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 904 RKSTLNpnaKEFNPRSFSQPKPSTTptSPRPQAQPSPSMVGHQQPTPVYTQPVCFAPNMMYPVPVSPGVQ--PLYPIPMT 981
Cdd:TIGR01628 367 RRAHLQ---DQFMQLQPRMRQLPMG--SPMGGAMGQPPYYGQGPQQQFNGQPLGWPRMSMMPTPMGPGGPlrPNGLAPMN 441
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 982 PMpvnqaktyRAVPNMPQQRQDQHHQSAMMHPASAAGPPIAATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQ------ 1055
Cdd:TIGR01628 442 AV--------RAPSRNAQNAAQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVLASATPQMQKQvlgerl 513
|
....*
gi 1777350999 1056 HPHVY 1060
Cdd:TIGR01628 514 FPLVE 518
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
562-753 |
1.68e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 42.56 E-value: 1.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 562 QSGPNSLPPRAAT----PTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSI 637
Cdd:PRK12323 367 QSGGGAGPATAAAapvaQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGG 446
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 638 SSGLEFVSHNPPSEAATPPVARTSPSGGTWSSV-VSGVPRLSPKTHRPRSPRQNSIGNTPSGPVLASPQAGIIPTEAVAM 716
Cdd:PRK12323 447 APAPAPAPAAAPAAAARPAAAGPRPVAAAAAAApARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESI 526
|
170 180 190
....*....|....*....|....*....|....*..
gi 1777350999 717 PIPAASPTPASPASNRAVTPSSEAKDSRLQDQRQNSP 753
Cdd:PRK12323 527 PDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAP 563
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
940-1164 |
2.98e-03 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 41.99 E-value: 2.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 940 PSMVGHQQPTPVYTQPVCFAPNMMYPVPVSPgVQPLYPIPMTPMPVNQaktyravPNMPQQRQdqhhqsammhPASAAGP 1019
Cdd:PRK10263 309 PLLNGAPITEPVAVAAAATTATQSWAAPVEP-VTQTPPVASVDVPPAQ-------PTVAWQPV----------PGPQTGE 370
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 1020 PIAATPPAystqyvAYSPQQFPNQPLVQHVPHYQSQHPHvyspviqgnarmmAPPTHAQPGLVSSSATQYGAHEQTHAMY 1099
Cdd:PRK10263 371 PVIAPAPE------GYPQQSQYAQPAVQYNEPLQQPVQP-------------QQPYYAPAAEQPAQQPYYAPAPEQPAQQ 431
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1777350999 1100 vstGSLAQQYAHPNATLHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQ 1164
Cdd:PRK10263 432 ---PYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPE 493
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
908-1266 |
3.29e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 42.23 E-value: 3.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 908 LNPNAKEFNPRSFSQPKPSTTPTSPRPQAQ--PSPSMVGHQQPTPVYTQPVCFAPNMMYPVP--VSPGVQPLYPI--PMT 981
Cdd:PHA03247 2624 PDPPPPSPSPAANEPDPHPPPTVPPPERPRddPAPGRVSRPRRARRLGRAAQASSPPQRPRRraARPTVGSLTSLadPPP 2703
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 982 PMPVNQAKTYRAVPNMPQQRQDQHHQSAMMHPASAAGPPIAATPPAYSTQYVAYSPQQFPNQPLVQHVPHyqsqhphvys 1061
Cdd:PHA03247 2704 PPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPA---------- 2773
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 1062 pviqgnARMMAPPTHAQPGLVSSSATQYGAHEQTHAMYVSTGSLAQQYAHPNATLHPHTPHPQPsatPTGQQQSQHGGSH 1141
Cdd:PHA03247 2774 ------APAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPP---TSAQPTAPPPPPG 2844
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 1142 PAPSPVQHHQHQAAQALHLASPQQQSAIyhagLAPTPPSMTPASNTQSPQnsfPAAQQTVFTIHPSHVQPAYTNPPHMAH 1221
Cdd:PHA03247 2845 PPPPSLPLGGSVAPGGDVRRRPPSRSPA----AKPAAPARPPVRRLARPA---VSRSTESFALPPDQPERPPQPQAPPPP 2917
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1777350999 1222 VPQAHVQSGMVPSHPTAHAPMMLMTTQPPGGPQAALAQSALQPIP 1266
Cdd:PHA03247 2918 QPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQP 2962
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
654-1101 |
6.55e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 41.08 E-value: 6.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 654 TPPVARTSPSGGTWSSVVSGVPRLSP-------KTHRPRSPRQNSIGNTP---SGPVLASPQAGIIPTEAVAMPIPAASP 723
Cdd:PHA03247 2552 PPPLPPAAPPAAPDRSVPPPRPAPRPsepavtsRARRPDAPPQSARPRAPvddRGDPRGPAPPSPLPPDTHAPDPPPPSP 2631
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 724 TPAS---PASNRAVTPSSEAKDSRLQDQRQNSPAGNKENIKPNETSPSFSKAENKGISPIVSEHRKQIDDLKKFKNDfRL 800
Cdd:PHA03247 2632 SPAAnepDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTP-EP 2710
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 801 QPSSTSESMDQLLNKNREAEKSRDLIKDKIEPSAKDS----FTENSSSNCTSGSSKPNSPSISPSILSNTEHKRGPEVTS 876
Cdd:PHA03247 2711 APHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGpatpGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVAS 2790
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 877 QGVQTSSpackQEKDDKEEKKDAAEQVRKSTLNPNAKefnPRSFSQPKPSTTPTSPRPQAQPSPSMVG-----------H 945
Cdd:PHA03247 2791 LSESRES----LPSPWDPADPPAAVLAPAAALPPAAS---PAGPLPPPTSAQPTAPPPPPGPPPPSLPlggsvapggdvR 2863
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 946 QQPTPVYTQPVCFAPNMMY-------PVPVSPGVQPLYPIPMTPMPVNQAKTY-RAVPNMPQQRQDQHHQSAMMHPASAA 1017
Cdd:PHA03247 2864 RRPPSRSPAAKPAAPARPPvrrlarpAVSRSTESFALPPDQPERPPQPQAPPPpQPQPQPPPPPQPQPPPPPPPRPQPPL 2943
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 1018 gPPIAATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPhvySPVIQGNARMMAPPTHAQPGLVSSSATQYGAHEQTHA 1097
Cdd:PHA03247 2944 -APTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQP---APSREAPASSTPPLTGHSLSRVSSWASSLALHEETDP 3019
|
....
gi 1777350999 1098 MYVS 1101
Cdd:PHA03247 3020 PPVS 3023
|
|
| PAM2 |
pfam07145 |
Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various ... |
904-919 |
8.18e-03 |
|
Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various eukaryotic proteins as an important binding site for pfam00658. It has been found in a wide range of eukaryotic proteins. Strikingly, this motif appears to occur solely outside of globular domains.
Pssm-ID: 429316 Cd Length: 17 Bit Score: 34.89 E-value: 8.18e-03
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
865-1274 |
8.42e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 40.52 E-value: 8.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 865 NTEHKRGPEVTSQGVQTSSPACKQEKDDKEEKKDAAEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVG 944
Cdd:pfam03154 127 NDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSV 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 945 HQQPTPVYTQPVCFAPNMMYPVPVSPGVQPLYPiPMTPMPvNQAKTYRAVPNMPQQRQDQHHQSAMMHPASAAGP-PIAA 1023
Cdd:pfam03154 207 PPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHP-QRLPSP-HPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPhSLQT 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 1024 TPPaystqyvaYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMMA--PPTHAQPGLVSSSATQYGAHEQTHAMYVS 1101
Cdd:pfam03154 285 GPS--------HMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIhtPPSQSQLQSQQPPREQPLPPAPLSMPHIK 356
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 1102 TGSLAQQYAHPNATLHPHTPHpqpsatPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSM 1181
Cdd:pfam03154 357 PPPTTPIPQLPNPQSHKHPPH------LSGPSPFQMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQ 430
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777350999 1182 TPASnTQSPQNSFPAAQQ-TVFTIHPSHVQPAYTNPPHMAHVPqahvQSGMVPSHPTAHAPMMLMTTQPPggpqAALAQS 1260
Cdd:pfam03154 431 PPVL-TQSQSLPPPAASHpPTSGLHQVPSQSPFPQHPFVPGGP----PPITPPSGPPTSTSSAMPGIQPP----SSASVS 501
|
410
....*....|....
gi 1777350999 1261 ALQPIPVSTTAHFP 1274
Cdd:pfam03154 502 SSGPVPAAVSCPLP 515
|
|
| Sm_like |
cd00600 |
Sm and related proteins; The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to ... |
266-333 |
9.12e-03 |
|
Sm and related proteins; The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of this family share a highly conserved Sm fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta-sheet. Sm-like proteins exist in archaea as well as prokaryotes that form heptameric and hexameric ring structures similar to those found in eukaryotes.
Pssm-ID: 212462 [Multi-domain] Cd Length: 63 Bit Score: 36.07 E-value: 9.12e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1777350999 266 LTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTEsssgpKREEIMESILFKCSDFVVVQ 333
Cdd:cd00600 1 LKDFIGKTVSVELKDGRVLTGTLVAFDKYMNLVLDDVVETGRD-----GKVRVLGLVLIRGSNIVSIR 63
|
|
| |
