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Conserved domains on  [gi|1207162292|ref|XP_021325026|]
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BTB/POZ domain-containing protein 2 isoform X2 [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHR pfam08005
PHR domain; This domain is called PHR as it was original found in the proteins PAM, highwire ...
 406-554 3.94e-78

PHR domain; This domain is called PHR as it was original found in the proteins PAM, highwire and RPM. This domain can be duplicated in the highwire, PFAM and PRM sequence. The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils.


:

Pssm-ID: 462339  Cd Length: 150  Bit Score: 242.53  E-value: 3.94e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162292 406 RFSQVESRWGYSGTS-DRIRFSVNRRIFVVGFGLYGSIHGPTDYQVNIQIIHTD----SNTVLGQNDTGFSCDGTASTFR 480
Cdd:pfam08005   2 RFQSTGGGWGYSGGSpDAIRFSVDRDIFLVGFGLYGSIGGPADYSVKIELIDGErwesLGEVLGENDTTFSSDGSNDIFR 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207162292 481 VMFKEPVEILPSVNYIACATLKGPDSHYGTKGMRKVTHeapatGTKTCFTFCYAAGNNNGTSVEDGQIPEVIFY 554
Cdd:pfam08005  82 VLFDEPVEIEPNVKYTASAKIKGPSSYYGTNGLREVTC-----DGGVTFQFSSSSLSNNGTSVNRGQIPELLYY 150
BACK_BTBD2 cd18523
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2); ...
 247-352 8.93e-71

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.


:

Pssm-ID: 350598  Cd Length: 106  Bit Score: 222.17  E-value: 8.93e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162292 247 LRADNAFMLLTQARLFDEPQLASLCLENIDKNTADALAAEGFTDVDLDTLVAVLERDTLGVREVRLFGAAVRWAEAEAQR 326
Cdd:cd18523     1 LRADNAFMLLTQARLFDEPQLASLCLENIDKNTSDAINAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWAEAECQR 80

                          90       100
                  ....*....|....*....|....*.
gi 1207162292 327 QQLQPTPENKRRVLGKALALIRFPLM 352
Cdd:cd18523    81 QQLQVTPENKRKVLGKALSLIRFPLM 106
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 165-251 3.79e-53

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18281:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 127  Bit Score: 176.47  E-value: 3.79e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162292 165 NWQATKSTVKERFAFLFNNEVLSDVHFLVGKGMGVQRIPAH--------------------------------------- 205
Cdd:cd18281     1 NWQASKTTVKERFAFLFNNETLSDVHFIVGKGDNEQRIPAHkfvlsigsavfdamfnggmattsaeielpdvepaaflal 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1207162292 206 -RFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 251
Cdd:cd18281    81 lRFLYSDEVQIGPETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127
 
Name Accession Description Interval E-value
PHR pfam08005
PHR domain; This domain is called PHR as it was original found in the proteins PAM, highwire ...
 406-554 3.94e-78

PHR domain; This domain is called PHR as it was original found in the proteins PAM, highwire and RPM. This domain can be duplicated in the highwire, PFAM and PRM sequence. The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils.


Pssm-ID: 462339  Cd Length: 150  Bit Score: 242.53  E-value: 3.94e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162292 406 RFSQVESRWGYSGTS-DRIRFSVNRRIFVVGFGLYGSIHGPTDYQVNIQIIHTD----SNTVLGQNDTGFSCDGTASTFR 480
Cdd:pfam08005   2 RFQSTGGGWGYSGGSpDAIRFSVDRDIFLVGFGLYGSIGGPADYSVKIELIDGErwesLGEVLGENDTTFSSDGSNDIFR 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207162292 481 VMFKEPVEILPSVNYIACATLKGPDSHYGTKGMRKVTHeapatGTKTCFTFCYAAGNNNGTSVEDGQIPEVIFY 554
Cdd:pfam08005  82 VLFDEPVEIEPNVKYTASAKIKGPSSYYGTNGLREVTC-----DGGVTFQFSSSSLSNNGTSVNRGQIPELLYY 150
BACK_BTBD2 cd18523
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2); ...
 247-352 8.93e-71

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.


Pssm-ID: 350598  Cd Length: 106  Bit Score: 222.17  E-value: 8.93e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162292 247 LRADNAFMLLTQARLFDEPQLASLCLENIDKNTADALAAEGFTDVDLDTLVAVLERDTLGVREVRLFGAAVRWAEAEAQR 326
Cdd:cd18523     1 LRADNAFMLLTQARLFDEPQLASLCLENIDKNTSDAINAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWAEAECQR 80

                          90       100
                  ....*....|....*....|....*.
gi 1207162292 327 QQLQPTPENKRRVLGKALALIRFPLM 352
Cdd:cd18523    81 QQLQVTPENKRKVLGKALSLIRFPLM 106
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 165-251 3.79e-53

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 176.47  E-value: 3.79e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162292 165 NWQATKSTVKERFAFLFNNEVLSDVHFLVGKGMGVQRIPAH--------------------------------------- 205
Cdd:cd18281     1 NWQASKTTVKERFAFLFNNETLSDVHFIVGKGDNEQRIPAHkfvlsigsavfdamfnggmattsaeielpdvepaaflal 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1207162292 206 -RFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 251
Cdd:cd18281    81 lRFLYSDEVQIGPETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 259-358 7.99e-14

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 67.37  E-value: 7.99e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162292  259 ARLFDEPQLASLCLENIDKNTADALAAEGFTDVDLDTLVAVLERDTLGVR-EVRLFGAAVRWAEAEaqrqqlqptPENKR 337
Cdd:smart00875   8 ADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSsEEEVFEAVLRWVKHD---------PEKRR 78

                           90       100
                   ....*....|....*....|.
gi 1207162292  338 RVLGKALALIRFPLMTIEEFA 358
Cdd:smart00875  79 EHLPELLEHVRLPLLSPDYLL 99
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 259-353 3.54e-07

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 48.70  E-value: 3.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162292 259 ARLFDEPQLASLCLENIDKNTADALAAEGFTDVDLDTLVAVLERDTLGV-REVRLFGAAVRWaeaeaqrqqLQPTPENKR 337
Cdd:pfam07707   8 ADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVpSEEEVFEAVIRW---------VKHDVERRK 78

                          90
                  ....*....|....*.
gi 1207162292 338 RVLGKALALIRFPLMT 353
Cdd:pfam07707  79 KHLPELLSAVRLPLLS 94
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 180-247 4.08e-07

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 48.41  E-value: 4.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162292 180 LFNNEVLSDVHFLVGKgmgvQRIPAHR-----------------------------------------FLYSDEVqIGPE 218
Cdd:pfam00651   4 LREQGELCDVTLVVGD----KEFRAHKavlaacspyfkalfsgqesessvseitlddvspedfealleFMYTGKL-ISEE 78

                          90       100
                  ....*....|....*....|....*....
gi 1207162292 219 TVMTTLYTAKKYAVPALEAHCVEFLKKNL 247
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
 
Name Accession Description Interval E-value
PHR pfam08005
PHR domain; This domain is called PHR as it was original found in the proteins PAM, highwire ...
 406-554 3.94e-78

PHR domain; This domain is called PHR as it was original found in the proteins PAM, highwire and RPM. This domain can be duplicated in the highwire, PFAM and PRM sequence. The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils.


Pssm-ID: 462339  Cd Length: 150  Bit Score: 242.53  E-value: 3.94e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162292 406 RFSQVESRWGYSGTS-DRIRFSVNRRIFVVGFGLYGSIHGPTDYQVNIQIIHTD----SNTVLGQNDTGFSCDGTASTFR 480
Cdd:pfam08005   2 RFQSTGGGWGYSGGSpDAIRFSVDRDIFLVGFGLYGSIGGPADYSVKIELIDGErwesLGEVLGENDTTFSSDGSNDIFR 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207162292 481 VMFKEPVEILPSVNYIACATLKGPDSHYGTKGMRKVTHeapatGTKTCFTFCYAAGNNNGTSVEDGQIPEVIFY 554
Cdd:pfam08005  82 VLFDEPVEIEPNVKYTASAKIKGPSSYYGTNGLREVTC-----DGGVTFQFSSSSLSNNGTSVNRGQIPELLYY 150
BACK_BTBD2 cd18523
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2); ...
 247-352 8.93e-71

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.


Pssm-ID: 350598  Cd Length: 106  Bit Score: 222.17  E-value: 8.93e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162292 247 LRADNAFMLLTQARLFDEPQLASLCLENIDKNTADALAAEGFTDVDLDTLVAVLERDTLGVREVRLFGAAVRWAEAEAQR 326
Cdd:cd18523     1 LRADNAFMLLTQARLFDEPQLASLCLENIDKNTSDAINAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWAEAECQR 80

                          90       100
                  ....*....|....*....|....*.
gi 1207162292 327 QQLQPTPENKRRVLGKALALIRFPLM 352
Cdd:cd18523    81 QQLQVTPENKRKVLGKALSLIRFPLM 106
BACK_BTBD1_like cd18487
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD1 and ...
 247-341 5.70e-64

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This subfamily includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.


Pssm-ID: 350562  Cd Length: 95  Bit Score: 203.74  E-value: 5.70e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162292 247 LRADNAFMLLTQARLFDEPQLASLCLENIDKNTADALAAEGFTDVDLDTLVAVLERDTLGVREVRLFGAAVRWAEAEAQR 326
Cdd:cd18487     1 LSSDNAFMLLTQARLFDEPQLASLCLETIDKNTAEALAAEGFTDIDLDTLCVVLERDTLGIRECKLFQAVLRWAEAECQR 80

                          90
                  ....*....|....*
gi 1207162292 327 QQLQPTPENKRRVLG 341
Cdd:cd18487    81 QGLSVTPENQRKVLG 95
BACK_BTBD1 cd18522
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 1 (BTBD1); ...
 247-353 3.86e-62

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein specifically expressed in skeletal muscle. It interacts with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. It may serve as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350597  Cd Length: 107  Bit Score: 199.52  E-value: 3.86e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162292 247 LRADNAFMLLTQARLFDEPQLASLCLENIDKNTADALAAEGFTDVDLDTLVAVLERDTLGVREVRLFGAAVRWAEAEAQR 326
Cdd:cd18522     1 LRADNAFMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDLDTLCAVLERDTLSIRESRLFGAVVRWAEAECQR 80

                          90       100
                  ....*....|....*....|....*..
gi 1207162292 327 QQLQPTPENKRRVLGKALALIRFPLMT 353
Cdd:cd18522    81 QQLPVTSENKQKVLGKALSLIRFPLMT 107
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 165-251 3.79e-53

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 176.47  E-value: 3.79e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162292 165 NWQATKSTVKERFAFLFNNEVLSDVHFLVGKGMGVQRIPAH--------------------------------------- 205
Cdd:cd18281     1 NWQASKTTVKERFAFLFNNETLSDVHFIVGKGDNEQRIPAHkfvlsigsavfdamfnggmattsaeielpdvepaaflal 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1207162292 206 -RFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 251
Cdd:cd18281    81 lRFLYSDEVQIGPETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 165-251 5.01e-47

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 160.62  E-value: 5.01e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162292 165 NWQATKSTVKERFAFLFNNEVLSDVHFLVGKGMGVQRIPAHRF------------------------------------- 207
Cdd:cd18347     1 NWQATKPTVQERFAFLFNNEVLSDVHFLVGKGLGSQRIPAHRFvlavgsavfdamfnggmattsteielpdvepaaflal 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1207162292 208 ---LYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 251
Cdd:cd18347    81 lkfLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 127
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 165-251 7.33e-44

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 152.13  E-value: 7.33e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162292 165 NWQATKSTVKERFAFLFNNEVLSDVHFLVGKG------MGVQRIPAH--------------------------------- 205
Cdd:cd18346     1 NWQATKSSLKERFAFLFNNELLSDVRFVVGKGrprgpgPGAQRIPAHrfvlaagsavfdamfnggmattsaeielpdvep 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1207162292 206 -------RFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 251
Cdd:cd18346    81 aaflallRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADN 133
BACK_BTBD3_like cd18488
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and ...
 247-341 1.77e-38

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This subfamily includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.


Pssm-ID: 350563  Cd Length: 95  Bit Score: 136.34  E-value: 1.77e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162292 247 LRADNAFMLLTQARLFDEPQLASLCLENIDKNTADALAAEGFTDVDLDTLVAVLERDTLGVREVRLFGAAVRWAEAEAQR 326
Cdd:cd18488     1 LSARNACVLLSQSRLFEEPELMQRCWEVIDAQAELALKSEGFTEIDYKTLESILRRETLNAKESVVFEAALRWAEAECQR 80

                          90
                  ....*....|....*
gi 1207162292 327 QQLQPTPENKRRVLG 341
Cdd:cd18488    81 RGLEPTPENKRKVLG 95
BACK_BTBD3 cd18524
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 3 (BTBD3); ...
 247-341 5.31e-30

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in mammalian neocortex.


Pssm-ID: 350599  Cd Length: 95  Bit Score: 112.90  E-value: 5.31e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162292 247 LRADNAFMLLTQARLFDEPQLASLCLENIDKNTADALAAEGFTDVDLDTLVAVLERDTLGVREVRLFGAAVRWAEAEAQR 326
Cdd:cd18524     1 LSAKNACVLLSQSCLFEEPDLTQRCWEVIDAQAELALKSEGFCDIDFQTLESILRRETLNAKEIVVFEAALNWAEVECQR 80

                          90
                  ....*....|....*
gi 1207162292 327 QQLQPTPENKRRVLG 341
Cdd:cd18524    81 QELQPTIENKRKVLG 95
BACK_BTBD6 cd18525
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6); ...
 247-341 1.67e-29

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also called lens BTB domain protein, is a BTB-domain-containing Kelch-like protein that is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.


Pssm-ID: 350600  Cd Length: 95  Bit Score: 111.72  E-value: 1.67e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162292 247 LRADNAFMLLTQARLFDEPQLASLCLENIDKNTADALAAEGFTDVDLDTLVAVLERDTLGVREVRLFGAAVRWAEAEAQR 326
Cdd:cd18525     1 LEAKNACVLLSQSRLFEEPELTQRCWEVIDAQAELALKSEGFCEIDQQTLEIILTRETLNTKEVVVFEAVLNWAEAECKR 80

                          90
                  ....*....|....*
gi 1207162292 327 QQLQPTPENKRRVLG 341
Cdd:cd18525    81 QGLPPTARNKRNVLG 95
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 180-247 1.73e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 92.46  E-value: 1.73e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162292 180 LFNNEVLSDVHFLVGKGMGVQRIPAH----------------------------------------RFLYSDEVQIGPET 219
Cdd:cd18282     1 MFNNELMADVHFIVGPPGGTQRIPAHkyvlatgssvfyamfygglaenkneieipdvepaaflnllRYLYCDEIDLEPDT 80

                          90       100
                  ....*....|....*....|....*...
gi 1207162292 220 VMTTLYTAKKYAVPALEAHCVEFLKKNL 247
Cdd:cd18282    81 VLATLYAAKKYLVPHLARACVQFLETSL 108
BTB_POZ_BTBD3 cd18348
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 166-256 6.31e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349657 [Multi-domain]  Cd Length: 131  Bit Score: 83.14  E-value: 6.31e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162292 166 WQATKSTVKERFAFLFNNEVLSDVHFLVGKGMGVQRIPAH---------------------------------------- 205
Cdd:cd18348     1 WQGLYPTIRERNAVMFNNDLMADIHFVVGPPGGTQRLPGHkyvlavgssvfhamfygelaedkdeiripdvepaaflaml 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1207162292 206 RFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLL 256
Cdd:cd18348    81 KYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLL 131
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 180-247 1.31e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 78.49  E-value: 1.31e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162292 180 LFNNEVLSDVHFLVGKGMGVQRIPAHRF----------------------------------------LYSDEVQIGPET 219
Cdd:cd18349     2 MFNNELMADVHFIVGPPGASQRVPAHKYvlavgssvfyamfygdlaevkseihipdvepaaflillkyMYSDEIDLEADT 81

                          90       100
                  ....*....|....*....|....*...
gi 1207162292 220 VMTTLYTAKKYAVPALEAHCVEFLKKNL 247
Cdd:cd18349    82 VLATLYAAKKYIVPALAKACVNFLETSL 109
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 259-358 7.99e-14

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 67.37  E-value: 7.99e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162292  259 ARLFDEPQLASLCLENIDKNTADALAAEGFTDVDLDTLVAVLERDTLGVR-EVRLFGAAVRWAEAEaqrqqlqptPENKR 337
Cdd:smart00875   8 ADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSsEEEVFEAVLRWVKHD---------PEKRR 78

                           90       100
                   ....*....|....*....|.
gi 1207162292  338 RVLGKALALIRFPLMTIEEFA 358
Cdd:smart00875  79 EHLPELLEHVRLPLLSPDYLL 99
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 247-356 1.17e-11

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 61.09  E-value: 1.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162292 247 LRADNAFMLLTQARLFDEPQLASLCLENIDKNTADALAAEGFTDVDLDTLVAVLERDTLGVREVRLFGAAVRWAEAEaqr 326
Cdd:cd14822     1 LNIRNVCLIYDVASLYSLDDLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSRDSFCAPEVDIFNAVRRWCEHN--- 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 1207162292 327 qqlQPTPENKRRVlgkaLALIRFPLMTIEE 356
Cdd:cd14822    78 ---PDSKEDAKEI----LEAVRLPLMSLTE 100
BACK_GPRS_like cd18507
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster serine-enriched ...
 249-320 1.34e-07

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster serine-enriched protein (GPRS) and similar proteins; The family includes uncharacterized Drosophila melanogaster serine-enriched protein (GPRS) and similar proteins.


Pssm-ID: 350582  Cd Length: 80  Bit Score: 49.05  E-value: 1.34e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207162292 249 ADNAFMLLTQARLFDEPQ----LASLCLENIDKNTADALAAEGFTDVDLDTLVAVLERDTLGVREVRLFGAAVRWA 320
Cdd:cd18507     2 VDTVCALLASAERYDQYKctktLVQKVLEFVDKHGTDVLNLPEFLLLPEHVVRLILSRDSLGADEMTKFQAALAWS 77
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 259-353 3.54e-07

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 48.70  E-value: 3.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162292 259 ARLFDEPQLASLCLENIDKNTADALAAEGFTDVDLDTLVAVLERDTLGV-REVRLFGAAVRWaeaeaqrqqLQPTPENKR 337
Cdd:pfam07707   8 ADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVpSEEEVFEAVIRW---------VKHDVERRK 78

                          90
                  ....*....|....*.
gi 1207162292 338 RVLGKALALIRFPLMT 353
Cdd:pfam07707  79 KHLPELLSAVRLPLLS 94
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 180-247 4.08e-07

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 48.41  E-value: 4.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162292 180 LFNNEVLSDVHFLVGKgmgvQRIPAHR-----------------------------------------FLYSDEVqIGPE 218
Cdd:pfam00651   4 LREQGELCDVTLVVGD----KEFRAHKavlaacspyfkalfsgqesessvseitlddvspedfealleFMYTGKL-ISEE 78

                          90       100
                  ....*....|....*....|....*....
gi 1207162292 219 TVMTTLYTAKKYAVPALEAHCVEFLKKNL 247
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 249-302 2.14e-05

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 42.26  E-value: 2.14e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1207162292 249 ADNAFMLLTQARLFDEPQLASLCLENIDKNTADALAAEGFTDVDLDTLVAVLER 302
Cdd:cd14733     2 PENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 256-319 4.70e-05

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 41.80  E-value: 4.70e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207162292 256 LTQARLFDEPQLASLCLENIDKNTADALAAEGFTDVDLDTLVAVLERDTLGVR-EVRLFGAAVRW 319
Cdd:cd18493     9 LQYAKMCGHKELAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEdEYTLFQAVEKW 73
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 247-324 9.65e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 40.95  E-value: 9.65e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207162292 247 LRADNAFMLLTQARLFDEPQLASLCLENIDKNTADALAAEGFTDVDLDTLVAVLERDTLGVR-EVRLFGAAVRWAEAEA 324
Cdd:cd18474     1 IGANNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRsEEVVLEAALRWVDADP 79
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 275-350 1.71e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 40.87  E-value: 1.71e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207162292 275 IDKNTADALAAEGFTDVDLDTLVAVLERDTL-GVREVRLFGAAVRWAEAEAQRQQLQptpenkrrvlGKALALIRFP 350
Cdd:cd18449    29 ILKNFPALLSTGDFVKLPFERLAFVLSSNSLkGCTELELFKAACRWLRHEDDRMQFA----------AKLMENIRFP 95
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 249-351 1.81e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 40.80  E-value: 1.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162292 249 ADNAFMLLTQARLFDEPQLASLCLENIDKNTADALAAEGFTDVDLDTLVAVLERDTLGVR-EVRLFGAAVRWaeaeaqrq 327
Cdd:cd18447     4 ASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRaEDQVYDAAVRW-------- 75

                          90       100
                  ....*....|....*....|....
gi 1207162292 328 qLQPTPENKRRVLGKALALIRFPL 351
Cdd:cd18447    76 -LKYDEPNRQPYMVDILAKVRFPL 98
BACK_BTBD19 cd18494
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); ...
 250-320 2.69e-04

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB-domain-containing Kelch-like protein. Its function remains unclear.


Pssm-ID: 350569  Cd Length: 73  Bit Score: 39.60  E-value: 2.69e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207162292 250 DNAFMLLTQARLFDEPQLASLCLENIDKNTADALAAEGFTDVDLDTLVAVLERDTLGVREVRLFGAAVRWA 320
Cdd:cd18494     3 ETACEALQAAVTYGQDELKERCLAFIEEHTEEVFKTKGFHELSDEALSVILRSDKLRIDELDILKAVREWA 73
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 170-242 3.06e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 40.35  E-value: 3.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162292 170 KSTVKERFAFLFNNEVLSDVHFLVgkgmGVQRIPAH-------------------------------------------- 205
Cdd:cd18292     1 SREFLQDIAQLYNNEELSDIVLRV----GGKVFHAHrlilakssdvfrvmlsndwwseskqseielvedpecaavfekfl 76

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1207162292 206 RFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEF 242
Cdd:cd18292    77 RYLYTGQISVNLETALPLLMLADKYNVTDLKQLCVDF 113
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 247-352 1.11e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 38.60  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162292 247 LRADNAFMLLtqaRLFDEPQLASL--CLEN-IDKNTADALAAEGFTDVDLDTLVAVLERDTLGV-REVRLFGAAVRWAEA 322
Cdd:cd18446     1 LHPENCVGIL---RLADAHSLESLkkQVQNyIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVtEEEQVFETVMRWVRY 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1207162292 323 -EAQRQQLQPtpenkrrvlgKALALIRFPLM 352
Cdd:cd18446    78 kESERLPLLP----------RVLENVRLPLL 98
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 206-247 1.65e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 38.43  E-value: 1.65e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1207162292 206 RFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNL 247
Cdd:cd18296    79 YYIYTDDTDLPPENAYDVLYVADMYLLPGLKRLCGTVLAQSL 120
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 286-352 3.41e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 37.20  E-value: 3.41e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207162292 286 EGFTDVDLDTLVAVLERDTL-GVREVRLFGAAVRWAEAEAQRqqlqptpenkRRVLGKALALIRFPLM 352
Cdd:cd18465    40 EDFLHLPLERLVFFLQSNKLkNCSEIDLFRAAIRWLQHDPSR----------RASASHVLCHIRFPLM 97
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 251-353 8.44e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 35.97  E-value: 8.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162292 251 NAFMLLTQARLFDEPQLASLCLENIDKNTADALAAEGFTDVDLDTLVAVLERDTLGV-REVRLFGAAVRWAEaEAQrqql 329
Cdd:cd18477     5 NCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVeKEEAVFEAVMKWVR-EAK---- 79

                          90       100
                  ....*....|....*....|....
gi 1207162292 330 qptpENKRRVLGKALALIRFPLMT 353
Cdd:cd18477    80 ----ENRQKALPTVFESIRFRLLP 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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