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Conserved domains on  [gi|1191883066|ref|XP_020948846|]
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aquaporin-4 isoform X1 [Sus scrofa]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 11088534)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11473620|8849412|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 31-248 1.76e-84

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


:

Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 254.16  E-value: 1.76e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066  31 TQAFWKAVTAEFLAMLIFVLLSLGSTINWGGA-EKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRK 109
Cdd:pfam00230   4 SVSFLRAVIAEFLATLLFVFFGVGSALGVKKLvSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066 110 ISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGNLSAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSI 189
Cdd:pfam00230  84 FSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSLGTV 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066 190 A-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLY 248
Cdd:pfam00230 164 ApLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 31-248 1.76e-84

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 254.16  E-value: 1.76e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066  31 TQAFWKAVTAEFLAMLIFVLLSLGSTINWGGA-EKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRK 109
Cdd:pfam00230   4 SVSFLRAVIAEFLATLLFVFFGVGSALGVKKLvSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066 110 ISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGNLSAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSI 189
Cdd:pfam00230  84 FSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSLGTV 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066 190 A-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLY 248
Cdd:pfam00230 164 ApLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 36-251 4.97e-73

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 224.83  E-value: 4.97e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066  36 KAVTAEFLAMLIFVLLSLGSTINWGGAEKpLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKS 115
Cdd:cd00333     1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGG-ASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066 116 VFYIAAQCLGAIIGAGILYLVTPPSVVGGLGV---------TTVHGNLSAGHGLLVELIITFQLVFTIFASCDSKRTDVT 186
Cdd:cd00333    80 IPYIIAQLLGAILGAALLYGLYYGLYLEFLGAnnivagifgTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNGPPP 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1191883066 187 GSIA-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGN---WENHWIYWVGPIIGAVLAGGLYEYV 251
Cdd:cd00333   160 GGLApLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLarhWHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 40-248 5.16e-68

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 211.77  E-value: 5.16e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066  40 AEFLAMLIFVLLSLGST--INWGGAEKPLPV-DMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSV 116
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSAlgVNVAGAYGAVGGgQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066 117 FYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGN-LSAGHGLLVELIITFQLVFTIFASCD-SKRTDVTGSIALAIG 194
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAgVSSGQAFFVEFIGTAILVLVIFATTDdRNRVPRGGFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1191883066 195 FSVAIGHLFAINYTGASMNPARSFGPAVI--MGNWENHWIYWVGPIIGAVLAGGLY 248
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFagLAGWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 34-252 1.95e-61

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 195.35  E-value: 1.95e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066  34 FWKAVTAEFLAMLIFVLLSLGSTINWGGAekPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIA 113
Cdd:COG0580     2 LMKRLLAEFLGTFILVLLGCGVVAVLAGT--KGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066 114 KSVFYIAAQCLGAIIGAGILYLV--------TPPSVVGGLGVTTVHGNLSAGHGLLVELIITFQLVFTIFASCDSKRTDv 185
Cdd:COG0580    80 DVLPYIIAQLLGAFLGAALVYLIygghfdatEDGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAAP- 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1191883066 186 TGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIM------GNWENHWIYWVGPIIGAVLAGGLYEYVF 252
Cdd:COG0580   159 GGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHalgkggSDWGYLWVPIVAPILGAALAALLYRALF 231
PLN00166 PLN00166
aquaporin TIP2; Provisional
 36-252 2.92e-44

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 152.01  E-value: 2.92e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066  36 KAVTAEFLAMLIFVLLSLGSTINWGGAEKPLPVD---MVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISI 112
Cdd:PLN00166   19 KAYLSEFIATLLFVFAGVGSAIAFAKLTSDAALDpagLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGGNITI 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066 113 AKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTTvhgNLSAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIA-L 191
Cdd:PLN00166   99 ITGFFYWIAQCLGSIVACLLLVFVTNGESVPTHGVAA---GLGAIEGVVMEIVVTFALVYTVYATAADPKKGSLGTIApI 175

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1191883066 192 AIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVF 252
Cdd:PLN00166  176 AIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFSQIWIYWVGPLVGGALAGLIYGDVF 236
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 31-248 1.76e-84

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 254.16  E-value: 1.76e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066  31 TQAFWKAVTAEFLAMLIFVLLSLGSTINWGGA-EKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRK 109
Cdd:pfam00230   4 SVSFLRAVIAEFLATLLFVFFGVGSALGVKKLvSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066 110 ISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGNLSAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSI 189
Cdd:pfam00230  84 FSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSLGTV 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066 190 A-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLY 248
Cdd:pfam00230 164 ApLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 36-251 4.97e-73

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 224.83  E-value: 4.97e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066  36 KAVTAEFLAMLIFVLLSLGSTINWGGAEKpLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKS 115
Cdd:cd00333     1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGG-ASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066 116 VFYIAAQCLGAIIGAGILYLVTPPSVVGGLGV---------TTVHGNLSAGHGLLVELIITFQLVFTIFASCDSKRTDVT 186
Cdd:cd00333    80 IPYIIAQLLGAILGAALLYGLYYGLYLEFLGAnnivagifgTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNGPPP 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1191883066 187 GSIA-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGN---WENHWIYWVGPIIGAVLAGGLYEYV 251
Cdd:cd00333   160 GGLApLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLarhWHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 40-248 5.16e-68

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 211.77  E-value: 5.16e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066  40 AEFLAMLIFVLLSLGST--INWGGAEKPLPV-DMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSV 116
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSAlgVNVAGAYGAVGGgQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066 117 FYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGN-LSAGHGLLVELIITFQLVFTIFASCD-SKRTDVTGSIALAIG 194
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAgVSSGQAFFVEFIGTAILVLVIFATTDdRNRVPRGGFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1191883066 195 FSVAIGHLFAINYTGASMNPARSFGPAVI--MGNWENHWIYWVGPIIGAVLAGGLY 248
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFagLAGWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 34-252 1.95e-61

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 195.35  E-value: 1.95e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066  34 FWKAVTAEFLAMLIFVLLSLGSTINWGGAekPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIA 113
Cdd:COG0580     2 LMKRLLAEFLGTFILVLLGCGVVAVLAGT--KGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066 114 KSVFYIAAQCLGAIIGAGILYLV--------TPPSVVGGLGVTTVHGNLSAGHGLLVELIITFQLVFTIFASCDSKRTDv 185
Cdd:COG0580    80 DVLPYIIAQLLGAFLGAALVYLIygghfdatEDGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAAP- 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1191883066 186 TGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIM------GNWENHWIYWVGPIIGAVLAGGLYEYVF 252
Cdd:COG0580   159 GGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHalgkggSDWGYLWVPIVAPILGAALAALLYRALF 231
PLN00166 PLN00166
aquaporin TIP2; Provisional
 36-252 2.92e-44

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 152.01  E-value: 2.92e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066  36 KAVTAEFLAMLIFVLLSLGSTINWGGAEKPLPVD---MVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISI 112
Cdd:PLN00166   19 KAYLSEFIATLLFVFAGVGSAIAFAKLTSDAALDpagLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGGNITI 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066 113 AKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTTvhgNLSAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIA-L 191
Cdd:PLN00166   99 ITGFFYWIAQCLGSIVACLLLVFVTNGESVPTHGVAA---GLGAIEGVVMEIVVTFALVYTVYATAADPKKGSLGTIApI 175

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1191883066 192 AIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVF 252
Cdd:PLN00166  176 AIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFSQIWIYWVGPLVGGALAGLIYGDVF 236
PLN00027 PLN00027
aquaporin TIP; Provisional
 36-252 9.02e-44

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 150.71  E-value: 9.02e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066  36 KAVTAEFLAMLIFVLLSLGSTINW-----GGAEKPLPVDMVLISLCFGLSIATMVQCfgHISGGHINPAVTVAMVCTRKI 110
Cdd:PLN00027   21 KAALAEFISTLIFVFAGEGSGMAFnkltdNGSTTPAGLVAAALAHAFALFVAVSVGA--NISGGHVNPAVTFGAFIGGNI 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066 111 SIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTTvhgNLSAGHGLLVELIITFQLVFTIFASC-DSKRTDVtGSI 189
Cdd:PLN00027   99 TLLRGILYWIAQLLGSVVACLLLKFSTGGLETSAFSLSS---GVGVWNAFVFEIVMTFGLVYTVYATAvDPKKGDL-GII 174

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1191883066 190 A-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVF 252
Cdd:PLN00027  175 ApIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELIF 238
PRK05420 PRK05420
aquaporin Z; Provisional
 36-252 3.15e-39

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 138.18  E-value: 3.15e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066  36 KAVTAEFLAMLIFVLLSLGSTInWGGAEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKS 115
Cdd:PRK05420    3 KKLAAEFFGTFWLVFGGCGSAV-LAAAFPELGIGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKEL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066 116 VFYIAAQCLGAIIGAGILYLVTPP----SVVGGLGVTTVHGNLSAGH-----GLLVELIITFQLVFTIFASCDsKRTDVt 186
Cdd:PRK05420   82 VPYIIAQVVGGIAAAAVLYLIASGkagfDLAGSGFASNGYGEHSPGGysllaALVCEVVLTAFFLLVILGATD-KRAPA- 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1191883066 187 GSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNW--ENHWIYWVGPIIGAVLAGGLYEYVF 252
Cdd:PRK05420  160 GFAPIAIGLALTLIHLISIPVTNTSVNPARSTGVALFVGGWalEQLWLFWVAPIVGAIIGGLIYRLLL 227
PLN00167 PLN00167
aquaporin TIP5; Provisional
 21-254 6.79e-36

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 130.02  E-value: 6.79e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066  21 TIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINW-----GGAEKPLPVDMVLISLCFGLSIATMVQcfGHISGGH 95
Cdd:PLN00167    8 SLSARFQQSVTRNALRSYLAEFISTFFFVFAAVGSAMSSrklmpDAASDPSSLLIVAIANAFALSSAVYIA--ANISGGH 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066  96 INPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTppsVVGGLGVTTVHGNLSAGHGLLVELIITFQLVFTIF 175
Cdd:PLN00167   86 VNPAVTFGMAVGGHISVPTAMFYWISQMLASVMACLFLKVTT---VGQHVPTYKIAEEMTGFGASVLEGVLTFGLVYTVY 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1191883066 176 ASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCP 254
Cdd:PLN00167  163 AAGDPRRGLLGAIGPLAIGLVAGANVLAAGPFSGGSMNPACAFGSAVVAGSFKNQAVYWVGPLLGGAVAGLLYDNVVFP 241
PLN00026 PLN00026
aquaporin NIP; Provisional
 36-257 5.36e-33

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 123.43  E-value: 5.36e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066  36 KAVTAEFLAMLIFVLLSLGSTI---NWGGAEKPLPvdmvlISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISI 112
Cdd:PLN00026   72 RKLGAEFVGTFILIFAATAGPIvnqKYDGAETLIG-----NAACAGLAVMIVILSTGHISGAHLNPSLTIAFAALRHFPW 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066 113 AKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTTVhgnlSAGHGLLVELIITFQLVFTIFASCDSKRTdvTGSIA-L 191
Cdd:PLN00026  147 KHVPAYIAAQVSASICASFALKGVFHPFMSGGVTVPSV----STGQAFALEFIITFNLLFVVTAVATDTRA--VGELAgI 220

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1191883066 192 AIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVE 257
Cdd:PLN00026  221 AVGATVMLNILVAGPSTGGSMNPVRTLGPAVAAGNYRAIWIYLVAPTLGALAGAGTYTAVKLREED 286
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 73-276 7.50e-31

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 117.70  E-value: 7.50e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066  73 ISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYL---VTPPSVVGglgvTT 149
Cdd:PLN00182   78 ICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWYQVPLYIGAQLTGSLLASLTLRLmfnVTPEAFFG----TT 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066 150 VHGnlSAGHGLLVELIITFQLVFTIFASCDSKRTdvTGSIA-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWE 228
Cdd:PLN00182  154 PTD--SSGQALVAEIIISFLLMFVISGVATDSRA--VGELAgIAVGMTIILNVFVAGPISGASMNPARSLGPAIVMGRYK 229

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1191883066 229 NHWIYWVGPIIGAVLAGGLYEYVFCPDVELKRRFKEA-FSKA-SQQTKGS 276
Cdd:PLN00182  230 GIWVYIVGPFVGIIAGGFVYNLIRFTDKPLRELTKSAsFLRSvSQKHNAS 279
PLN00184 PLN00184
aquaporin NIP1; Provisional
 34-259 4.14e-27

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 107.80  E-value: 4.14e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066  34 FWKAVTAEFLAMLIFVLLSLGSTINwgGAEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIA 113
Cdd:PLN00184   53 FLQKLIAEVLGTYFLVFTGCASVVV--NMQNDNVVTLPGIAIVWGLTIMVLIYSLGHISGAHINPAVTIAFASCGRFPLK 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066 114 KSVFYIAAQCLGAIIGAGILYLV--TPPSVVGG-----LGVTTVHGNLSAghgLLVELIITFQLVFTIFASCDSKRTdvT 186
Cdd:PLN00184  131 QVPAYVISQVIGSTLAAATLRLLfgLDHDVCSGkhdvfIGSSPVGSDLQA---FVMEFIVTFYLMFIISGVATDNRA--I 205

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1191883066 187 GSIA-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVELK 259
Cdd:PLN00184  206 GELAgLAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYGCYKGIWIYIVAPTLGAIAGAWVYNTVRYTDKPLR 279
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 78-248 6.98e-22

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 93.00  E-value: 6.98e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066  78 GLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIG---AGILYLVTPPsvvgglgVTTVHGNL 154
Cdd:PLN00183   86 GLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPWSKVPLYITAQTVGSVLAtyvGVSVYGVKAD-------LMTTKPAQ 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066 155 SAGHGLLVELIITFQLVFtIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYW 234
Cdd:PLN00183  159 GCSSAFWVEFIATFIVMF-LAASLTSQPQSLGHLSGFVIGIAIGLAVLITGPVSGGSMNPARSLGPAIVSWDFKDIWIYI 237

                         170
                  ....*....|....
gi 1191883066 235 VGPIIGAVLAGGLY 248
Cdd:PLN00183  238 TAPTIGAVAGALMF 251
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 35-257 5.43e-21

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 90.96  E-value: 5.43e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066  35 WKAVTAEFLAMliFVLLSLGS----TINWGGAEKPLpvdmvlISLCFGLSIATMVQCF--GHISGGHINPAVTVAMVCTR 108
Cdd:PTZ00016   50 VREYVAEFLGT--FVLLFFGEgvvaTTHTVGNNGDY------LAITIGWGLGVTFGLLvsAGISGGHLNPAVTLGNAVFG 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066 109 KISIAKSVFYIAAQCLGAIIGAGILY--------------LVTPPSVVGGLGVTTVHGNLSAGHGLLVELIITFQLVFTI 174
Cdd:PTZ00016  122 KFPWKKLPGYFVAQLLGAFVGAACVYglyygffkdhgipeLPWETMANGFAGVFATYPREGNFYAIFSELILTAILLLVI 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191883066 175 FASCDSKRTDVTGSIALAIGFSV-AIGHLFAINyTGASMNPARSFGP----AVIMGN----WENH--WIYWVGPIIGAVL 243
Cdd:PTZ00016  202 LAITDPNNCPAFNYLPVAVGLLVfVIGISFGGN-TGYALNPARDLGPrlfsAILWGSevftKDNYyfWVPLVAPFVGAVL 280

                         250
                  ....*....|....
gi 1191883066 244 AGGLYEYVFCPDVE 257
Cdd:PTZ00016  281 GMFLYDKFIPPLIE 294
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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