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Conserved domains on  [gi|1046907751|ref|XP_017457609|]
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ankyrin repeat and SOCS box protein 9 isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
32-234 4.99e-35

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 127.76  E-value: 4.99e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  32 DWSPLHDAAIHGRLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCATVLISHGAQVNGMTIDWRTPLFNACVSGSQ 111
Cdd:COG0666    54 GALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNL 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751 112 DCVNLLLQHGAAPH-PESDLASPIHEAAKRGHAKCIESLAAHGANIDYNISHLGTPLYVACKNQQVDCAKKLLESGASVN 190
Cdd:COG0666   134 EIVKLLLEAGADVNaQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1046907751 191 -QGKGSDSPLHVVARMSSGELVHLLMDFGANAQTKNADGKRPVDL 234
Cdd:COG0666   214 aKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLL 258
SOCS super family cl02533
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 249-290 5.91e-17

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


The actual alignment was detected with superfamily member cd03728:

Pssm-ID: 470605  Cd Length: 42  Bit Score: 72.90  E-value: 5.91e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1046907751 249 EGPLSLMQLCRLRIRKCFGIRQHHKITGLLLPEDLKRFLLHL 290
Cdd:cd03728     1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
32-234 4.99e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 127.76  E-value: 4.99e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  32 DWSPLHDAAIHGRLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCATVLISHGAQVNGMTIDWRTPLFNACVSGSQ 111
Cdd:COG0666    54 GALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNL 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751 112 DCVNLLLQHGAAPH-PESDLASPIHEAAKRGHAKCIESLAAHGANIDYNISHLGTPLYVACKNQQVDCAKKLLESGASVN 190
Cdd:COG0666   134 EIVKLLLEAGADVNaQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1046907751 191 -QGKGSDSPLHVVARMSSGELVHLLMDFGANAQTKNADGKRPVDL 234
Cdd:COG0666   214 aKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLL 258
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 249-290 5.91e-17

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 72.90  E-value: 5.91e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1046907751 249 EGPLSLMQLCRLRIRKCFGIRQHHKITGLLLPEDLKRFLLHL 290
Cdd:cd03728     1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
36-122 2.31e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.84  E-value: 2.31e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  36 LHDAAIHGRLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCATVLISHgAQVNGMTIDWrTPLFNACVSGSQDCVN 115
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR-TALHYAARSGHLEIVK 78


                  ....*..
gi 1046907751 116 LLLQHGA 122
Cdd:pfam12796  79 LLLEKGA 85
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 27-214 1.79e-15

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 76.45  E-value: 1.79e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  27 GDVVSDwSPLHDAAIHGRLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCATVLISHGAQVNGMTIDWRTPLFNAC 106
Cdd:PLN03192  521 DDPNMA-SNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAI 599

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751 107 VSGSQDCVNLLLQHGAA--PHPESDLaspIHEAAKRGHAKCIESLAAHGANIDYNISHLGTPLYVACKNQQVDCAKKLLE 184
Cdd:PLN03192  600 SAKHHKIFRILYHFASIsdPHAAGDL---LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIM 676

                         170       180       190
                  ....*....|....*....|....*....|
gi 1046907751 185 SGASVNQGKGSDSplhvvarMSSGELVHLL 214
Cdd:PLN03192  677 NGADVDKANTDDD-------FSPTELRELL 699
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 250-288 1.55e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 55.25  E-value: 1.55e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1046907751 250 GPLSLMQLCRLRIRKCFGIRQHHKITGLLLPEDLKRFLL 288
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 252-289 1.62e-06

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 43.94  E-value: 1.62e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1046907751  252 LSLMQLCRLRIRKCFGirqhhKITGLLLPEDLKRFLLH 289
Cdd:smart00969   1 RSLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLY 33
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 165-190 1.77e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.26  E-value: 1.77e-03
                           10        20
                   ....*....|....*....|....*.
gi 1046907751  165 TPLYVACKNQQVDCAKKLLESGASVN 190
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 98-223 4.45e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 38.52  E-value: 4.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  98 WRTPLFNACVSGS-QDCVNLLLQHGAAPHPESDLaspIHEAAKRGHAKCIESL----AAHGANIDYNI---------SHL 163
Cdd:TIGR00870  52 GRSALFVAAIENEnLELTELLLNLSCRGAVGDTL---LHAISLEYVDAVEAILlhllAAFRKSGPLELandqytsefTPG 128

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1046907751 164 GTPLYVACKNQQVDCAKKLLESGASVN-----------QGKG----SDSPLHVVARMSSGELVHLLMDFGANAQT 223
Cdd:TIGR00870 129 ITALHLAAHRQNYEIVKLLLERGASVParacgdffvksQGVDsfyhGESPLNAAACLGSPSIVALLSEDPADILT 203
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
32-234 4.99e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 127.76  E-value: 4.99e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  32 DWSPLHDAAIHGRLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCATVLISHGAQVNGMTIDWRTPLFNACVSGSQ 111
Cdd:COG0666    54 GALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNL 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751 112 DCVNLLLQHGAAPH-PESDLASPIHEAAKRGHAKCIESLAAHGANIDYNISHLGTPLYVACKNQQVDCAKKLLESGASVN 190
Cdd:COG0666   134 EIVKLLLEAGADVNaQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1046907751 191 -QGKGSDSPLHVVARMSSGELVHLLMDFGANAQTKNADGKRPVDL 234
Cdd:COG0666   214 aKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLL 258
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
32-230 1.70e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 121.21  E-value: 1.70e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  32 DWSPLHDAAIHGRLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCATVLISHGAQVNGMTIDWRTPLFNACVSGSQ 111
Cdd:COG0666    87 GNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751 112 DCVNLLLQHGAAP-HPESDLASPIHEAAKRGHAKCIESLAAHGANIDYNISHLGTPLYVACKNQQVDCAKKLLESGASVN 190
Cdd:COG0666   167 EIVKLLLEAGADVnARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLN 246

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1046907751 191 -QGKGSDSPLHVVARMSSGELVHLLMDFGANAQTKNADGKR 230
Cdd:COG0666   247 aKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
31-234 7.17e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 114.28  E-value: 7.17e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  31 SDWSPLHDAAIHGRLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCATVLISHGAQVNGMTIDWRTPLFNACVSGS 110
Cdd:COG0666    20 LLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGD 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751 111 QDCVNLLLQHGAAPH-PESDLASPIHEAAKRGHAKCIESLAAHGANIDYNISHLGTPLYVACKNQQVDCAKKLLESGASV 189
Cdd:COG0666   100 LEIVKLLLEAGADVNaRDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADV 179

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1046907751 190 N-QGKGSDSPLHVVARMSSGELVHLLMDFGANAQTKNADGKRPVDL 234
Cdd:COG0666   180 NaRDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
31-193 1.27e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 108.12  E-value: 1.27e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  31 SDWSPLHDAAIHGRLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCATVLISHGAQVNGMTIDWRTPLFNACVSGS 110
Cdd:COG0666   119 DGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGH 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751 111 QDCVNLLLQHGAAP-HPESDLASPIHEAAKRGHAKCIESLAAHGANIDYNISHLGTPLYVACKNQQVDCAKKLLESGASV 189
Cdd:COG0666   199 LEIVKLLLEAGADVnAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLL 278


                  ....
gi 1046907751 190 NQGK 193
Cdd:COG0666   279 AAAL 282
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
33-167 1.21e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 81.15  E-value: 1.21e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  33 WSPLHDAAIHGRLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCATVLISHGAQVNGMTIDWRTPLFNACVSGSQD 112
Cdd:COG0666   154 NTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLE 233

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1046907751 113 CVNLLLQHGAAP-HPESDLASPIHEAAKRGHAKCIESLAAHGANIDYNISHLGTPL 167
Cdd:COG0666   234 IVKLLLEAGADLnAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 249-290 5.91e-17

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 72.90  E-value: 5.91e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1046907751 249 EGPLSLMQLCRLRIRKCFGIRQHHKITGLLLPEDLKRFLLHL 290
Cdd:cd03728     1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
36-122 2.31e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.84  E-value: 2.31e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  36 LHDAAIHGRLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCATVLISHgAQVNGMTIDWrTPLFNACVSGSQDCVN 115
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR-TALHYAARSGHLEIVK 78


                  ....*..
gi 1046907751 116 LLLQHGA 122
Cdd:pfam12796  79 LLLEKGA 85
Ank_2 pfam12796
Ankyrin repeats (3 copies);
69-159 3.83e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.07  E-value: 3.83e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  69 LHEACLRGHLSCATVLISHGAQVNGMTIDWRTPLFNACVSGSQDCVNLLLQHGAAPHPESDLaSPIHEAAKRGHAKCIES 148
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNGR-TALHYAARSGHLEIVKL 79

                          90
                  ....*....|.
gi 1046907751 149 LAAHGANIDYN 159
Cdd:pfam12796  80 LLEKGADINVK 90
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 27-214 1.79e-15

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 76.45  E-value: 1.79e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  27 GDVVSDwSPLHDAAIHGRLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCATVLISHGAQVNGMTIDWRTPLFNAC 106
Cdd:PLN03192  521 DDPNMA-SNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAI 599

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751 107 VSGSQDCVNLLLQHGAA--PHPESDLaspIHEAAKRGHAKCIESLAAHGANIDYNISHLGTPLYVACKNQQVDCAKKLLE 184
Cdd:PLN03192  600 SAKHHKIFRILYHFASIsdPHAAGDL---LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIM 676

                         170       180       190
                  ....*....|....*....|....*....|
gi 1046907751 185 SGASVNQGKGSDSplhvvarMSSGELVHLL 214
Cdd:PLN03192  677 NGADVDKANTDDD-------FSPTELRELL 699
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 43-232 2.32e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 72.69  E-value: 2.32e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  43 GRLLTLRNLI-SQGWPVNIITADHVSPLHEACLRGHLSCATVLISHGAQVNGMTIDWRTPLFNACVSGSQDCVNLLLQHG 121
Cdd:PHA02874   12 GDIEAIEKIIkNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNG 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751 122 AaphPESDLASPIHEaakrghAKCIESLAAHGANIDYNISHLGTPLYVACKNQQVDCAKKLLESGASVN-QGKGSDSPLH 200
Cdd:PHA02874   92 V---DTSILPIPCIE------KDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNiEDDNGCYPIH 162

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1046907751 201 VVARMSSGELVHLLMDFGANAQTKNADGKRPV 232
Cdd:PHA02874  163 IAIKHNFFDIIKLLLEKGAYANVKDNNGESPL 194
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 83-244 4.60e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 71.83  E-value: 4.60e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  83 VLISHGAQVNGMTIDW-RTPLFNACVSGSQDCVNLLLQHGAAPH-PESDLASPIHEAAKRGHAKCIESLAAHGANIDYNI 160
Cdd:PHA02878  152 LLLSYGADINMKDRHKgNTALHYATENKDQRLTELLLSYGANVNiPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARD 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751 161 SHLGTPLYVA---CKNqqVDCAKKLLESGASVNqGKGSD---SPLHVVARmsSGELVHLLMDFGANAQTKNADGKRPVDL 234
Cdd:PHA02878  232 KCGNTPLHISvgyCKD--YDILKLLLEHGVDVN-AKSYIlglTALHSSIK--SERKLKLLLEYGADINSLNSYKLTPLSS 306

                         170
                  ....*....|
gi 1046907751 235 VPLESPVIEI 244
Cdd:PHA02878  307 AVKQYLCINI 316
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 249-289 1.22e-13

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 63.67  E-value: 1.22e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1046907751 249 EGPLSLMQLCRLRIRKCFGIRQHHKITGLLLPEDLKRFLLH 289
Cdd:cd03716     1 STPRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLY 41
Ank_2 pfam12796
Ankyrin repeats (3 copies);
134-225 6.39e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.21  E-value: 6.39e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751 134 IHEAAKRGHAKCIESLAAHGANIDYNISHLGTPLYVACKNQQVDCAKKLLESGASVNQGKGsDSPLHVVARMSSGELVHL 213
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNG-RTALHYAARSGHLEIVKL 79

                          90
                  ....*....|..
gi 1046907751 214 LMDFGANAQTKN 225
Cdd:pfam12796  80 LLEKGADINVKD 91
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 251-289 1.82e-12

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 60.56  E-value: 1.82e-12
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1046907751 251 PLSLMQLCRLRIRKCFGIRQHHKITGLLLPEDLKRFLLH 289
Cdd:cd03587     2 PRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLY 40
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 33-221 1.89e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 66.94  E-value: 1.89e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  33 WSPLHDAAIHGRLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCATVLISHGAQVNGMTI-DWRTPLFNACVSGSQ 111
Cdd:PHA02875   36 ISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYkDGMTPLHLATILKKL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751 112 DCVNLLLQHGAAPH-PESDLASPIHEAAKRGHAKCIESLAAHGANIDYNISHLGTPLYVACKNQQVDCAKKLLESGASVN 190
Cdd:PHA02875  116 DIMKLLIARGADPDiPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANID 195

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1046907751 191 Q-GKGSDSPLHVVA-RMSSGELVHLLMDFGANA 221
Cdd:PHA02875  196 YfGKNGCVAALCYAiENNKIDIVRLFIKRGADC 228
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 48-219 4.65e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 66.24  E-value: 4.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  48 LRNLISQGWPVNIITADHVSPLHEA-CLRGHLSCATVLISHGAQVNGMTIDWRTPLFNACVSGSQDCVNLLLQHGAAPHP 126
Cdd:PHA02876  324 IRTLIMLGADVNAADRLYITPLHQAsTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEA 403

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751 127 ESD-LASPIHEAAKRGHA-KCIESLAAHGANIDYNISHLGTPLYVACKNQ-QVDCAKKLLESGASVNQ-GKGSDSPLHVV 202
Cdd:PHA02876  404 LSQkIGTALHFALCGTNPyMSVKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAiNIQNQYPLLIA 483

                         170
                  ....*....|....*..
gi 1046907751 203 ARMSSgeLVHLLMDFGA 219
Cdd:PHA02876  484 LEYHG--IVNILLHYGA 498
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 65-232 1.18e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 64.63  E-value: 1.18e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  65 HVSPLHEACLRGHLSCATVLISHGAQVNGMTIDWRTPLFNACVSGSQDCVNLLLQHGAAP-HPESDLASPIHEAAKRGHA 143
Cdd:PHA02875    2 DQVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPdVKYPDIESELHDAVEEGDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751 144 KCIESLAAHGANIDYNISHLG-TPLYVACKNQQVDCAKKLLESGASVN-QGKGSDSPLHVVARMSSGELVHLLMDFGANA 221
Cdd:PHA02875   82 KAVEELLDLGKFADDVFYKDGmTPLHLATILKKLDIMKLLIARGADPDiPNTDKFSPLHLAVMMGDIKGIELLIDHKACL 161

                         170
                  ....*....|.
gi 1046907751 222 QTKNADGKRPV 232
Cdd:PHA02875  162 DIEDCCGCTPL 172
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 250-288 1.55e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 55.25  E-value: 1.55e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1046907751 250 GPLSLMQLCRLRIRKCFGIRQHHKITGLLLPEDLKRFLL 288
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 35-248 3.75e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 60.28  E-value: 3.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  35 PLHDAAIHGRLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCATVLISHGAQVNgmtidwrtpLFNACVSGSQDCV 114
Cdd:PHA02878   40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCS---------VFYTLVAIKDAFN 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751 115 N-------LLLQHGAAPHPESDLASpIHEAAKRG--HAKCIESLAAHGANIDYNISHLG-TPLYVACKNQQVDCAKKLLE 184
Cdd:PHA02878  111 NrnveifkIILTNRYKNIQTIDLVY-IDKKSKDDiiEAEITKLLLSYGADINMKDRHKGnTALHYATENKDQRLTELLLS 189

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1046907751 185 SGASVNQ-GKGSDSPLHVVARMSSGELVHLLMDFGANAQTKNADGKRPVDLVP---LESPVIEIFLQR 248
Cdd:PHA02878  190 YGANVNIpDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVgycKDYDILKLLLEH 257
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 18-232 4.60e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 59.68  E-value: 4.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  18 LRFLSNPLMGDVVSDWS---PLHDAAIHGRLLTLRNLISQGWPVNIITADHVSPLHEACLRGH-----LSCATVLISHGA 89
Cdd:PHA03100   18 IKYIIMEDDLNDYSYKKpvlPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGA 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  90 QVNGMTIDWRTPLFNACV--SGSQDCVNLLLQHGAAPHP-ESDLASPIHEAAKRGHA--KCIESLAAHGANIDynishlg 164
Cdd:PHA03100   98 NVNAPDNNGITPLLYAISkkSNSYSIVEYLLDNGANVNIkNSDGENLLHLYLESNKIdlKILKLLIDKGVDIN------- 170

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046907751 165 tplyVACKnqqVDCakkLLESGASVN-QGKGSDSPLHVVARMSSGELVHLLMDFGANAQTKNADGKRPV 232
Cdd:PHA03100  171 ----AKNR---VNY---LLSYGVPINiKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPL 229
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 34-163 9.55e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 55.83  E-value: 9.55e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  34 SPLHDAAIH--GRLLTLRNLISQGWPVNIITADHVSPLHEA--CLRGHLSCATVLISHGAQVNGMT-----------IDW 98
Cdd:PHA03100  108 TPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYleSNKIDLKILKLLIDKGVDINAKNrvnyllsygvpINI 187

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1046907751  99 R-----TPLFNACVSGSQDCVNLLLQHGAAPHPESDLA-SPIHEAAKRGHAKCIESLAAHGANIDYNISHL 163
Cdd:PHA03100  188 KdvygfTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGdTPLHIAILNNNKEIFKLLLNNGPSIKTIIETL 258
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 99-258 2.63e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 54.23  E-value: 2.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  99 RTPLFNACVSGSQDCVNLLLQHGAAPHPE-SDLASPIHEAAKRGHAKCIESLAAHGANIDYNISHLGTPLYVACKNQQVD 177
Cdd:PHA02875    3 QVALCDAILFGELDIARRLLDIGINPNFEiYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751 178 CAKKLLESGASVNQ--GKGSDSPLHVVARMSSGELVHLLMDFGANAQTKNADGKRPVDLVPLESPV--IEIFLQREGPLS 253
Cdd:PHA02875   83 AVEELLDLGKFADDvfYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIkgIELLIDHKACLD 162


                  ....*
gi 1046907751 254 LMQLC 258
Cdd:PHA02875  163 IEDCC 167
Ank_4 pfam13637
Ankyrin repeats (many copies);
33-85 2.91e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.20  E-value: 2.91e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1046907751  33 WSPLHDAAIHGRLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCATVLI 85
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 64-235 4.06e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 54.30  E-value: 4.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  64 DHVSPLHEACLRGHLSCATVLISHGAQVNGMTIDWRTPLFNACVSGSQDCVNLLLQHGAAPHPES-DLASPIHEAAKRGH 142
Cdd:PHA02876  144 EYMKLIKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIAlDDLSVLECAVDSKN 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751 143 AKCIESLAAHGANIDYNishlGTPLYVACKNQQVDCAKKLLESGASVNQ-GKGSDSPLHVVARMSS-GELVHLLMDFGAN 220
Cdd:PHA02876  224 IDTIKAIIDNRSNINKN----DLSLLKAIRNEDLETSLLLYDAGFSVNSiDDCKNTPLHHASQAPSlSRLVPKLLERGAD 299

                         170
                  ....*....|....*
gi 1046907751 221 AQTKNADGKRPVDLV 235
Cdd:PHA02876  300 VNAKNIKGETPLYLM 314
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 34-222 4.32e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.91  E-value: 4.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  34 SPLHDAAIHGRLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCATVLISHGAQVNGMTI---------DWRTPLF- 103
Cdd:PHA02876  180 TPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKNDLsllkairneDLETSLLl 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751 104 ---NACVSGSQDCVNLLLQHGAAPHPESDLA------------------SPIHEAAKRGH-AKCIESLAAHGANIDYNIS 161
Cdd:PHA02876  260 ydaGFSVNSIDDCKNTPLHHASQAPSLSRLVpkllergadvnaknikgeTPLYLMAKNGYdTENIRTLIMLGADVNAADR 339

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1046907751 162 HLGTPLYVACK-NQQVDCAKKLLESGASVNQGKGSD-SPLHVVARMSSGELVHLLMDFGANAQ 222
Cdd:PHA02876  340 LYITPLHQASTlDRNKDIVITLLELGANVNARDYCDkTPIHYAAVRNNVVIINTLLDYGADIE 402
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 40-125 1.58e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 52.21  E-value: 1.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  40 AIHGRLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCATVLISHGAQVNGMTIDWRTPLFNACVSGSQDCVNLLLQ 119
Cdd:PTZ00322   90 AASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169


                  ....*.
gi 1046907751 120 HGAAPH 125
Cdd:PTZ00322  170 HSQCHF 175
Ank_4 pfam13637
Ankyrin repeats (many copies);
65-118 1.04e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.96  E-value: 1.04e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1046907751  65 HVSPLHEACLRGHLSCATVLISHGAQVNGMTIDWRTPLFNACVSGSQDCVNLLL 118
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 251-289 1.33e-06

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 44.22  E-value: 1.33e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1046907751 251 PLSLMQLCRLRIRKCFGiRQH-HKITGLLLPEDLKRFLLH 289
Cdd:cd03718     3 PLPLMDLCRRRVRVALG-RDRlEEIEQLPLPPSLKNYLLY 41
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 51-232 1.58e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 49.29  E-value: 1.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  51 LISQGWPVNIITADHVSPLHEACLRGHLS-CATVLISHGAQVNGMTIDWRTPLFNACVSG-SQDCVNLLLQHGAAPHPES 128
Cdd:PHA02876  259 LYDAGFSVNSIDDCKNTPLHHASQAPSLSrLVPKLLERGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAAD 338

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751 129 DL-ASPIHEAAKRGHAK-CIESLAAHGANIDYNISHLGTPLYVACKNQQVDCAKKLLESGASVNQ-GKGSDSPLHVVARM 205
Cdd:PHA02876  339 RLyITPLHQASTLDRNKdIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEAlSQKIGTALHFALCG 418

                         170       180
                  ....*....|....*....|....*...
gi 1046907751 206 SSGEL-VHLLMDFGANAQTKNADGKRPV 232
Cdd:PHA02876  419 TNPYMsVKTLIDRGANVNSKNKDLSTPL 446
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 252-289 1.62e-06

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 43.94  E-value: 1.62e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1046907751  252 LSLMQLCRLRIRKCFGirqhhKITGLLLPEDLKRFLLH 289
Cdd:smart00969   1 RSLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLY 33
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 45-244 1.74e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 49.29  E-value: 1.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  45 LLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCATVLISHGAQVNGMTIDWRTPLFNACVSGSQDCVNLLLQHGAAP 124
Cdd:PHA02876  158 LLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNI 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751 125 HpESDLA-------------------------------SPIHEAAKRGH-AKCIESLAAHGANIDYNISHLGTPLYVACK 172
Cdd:PHA02876  238 N-KNDLSllkairnedletslllydagfsvnsiddcknTPLHHASQAPSlSRLVPKLLERGADVNAKNIKGETPLYLMAK 316

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1046907751 173 N-QQVDCAKKLLESGASVNQGKG-SDSPLHVVARMS-SGELVHLLMDFGANAQTKNADGKRPVDLVPLESPVIEI 244
Cdd:PHA02876  317 NgYDTENIRTLIMLGADVNAADRlYITPLHQASTLDrNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVII 391
Ank_2 pfam12796
Ankyrin repeats (3 copies);
33-92 2.67e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 44.72  E-value: 2.67e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  33 WSPLHDAAIHGRLLTLRNLISQgWPVNIITaDHVSPLHEACLRGHLSCATVLISHGAQVN 92
Cdd:pfam12796  31 RTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGADIN 88
Ank_4 pfam13637
Ankyrin repeats (many copies);
132-183 4.02e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.42  E-value: 4.02e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1046907751 132 SPIHEAAKRGHAKCIESLAAHGANIDYNISHLGTPLYVACKNQQVDCAKKLL 183
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 251-290 4.46e-06

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 42.85  E-value: 4.46e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1046907751 251 PLSLMQLCRLRIRKCFGIRQHHKITGLLLPEDLKRFLLHL 290
Cdd:cd03729     3 PLSLQQLCRINLRKALGTRALEKIAKLNIPNRIIDYLSYN 42
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 26-183 5.50e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 47.57  E-value: 5.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  26 MGDVVSDWSPLHDAAIHGRLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCATVLISHGAQVNGMTIDWRTPLFNA 105
Cdd:PHA02878  162 MKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHIS 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751 106 CVS-GSQDCVNLLLQHGAAPHPESDLA--SPIHEAAKrgHAKCIESLAAHGANIDYNISHLGTPLYVACKNQQ-VDCAKK 181
Cdd:PHA02878  242 VGYcKDYDILKLLLEHGVDVNAKSYILglTALHSSIK--SERKLKLLLEYGADINSLNSYKLTPLSSAVKQYLcINIGRI 319


                  ..
gi 1046907751 182 LL 183
Cdd:PHA02878  320 LI 321
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 251-287 6.84e-06

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 42.17  E-value: 6.84e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1046907751 251 PLSLMQLCRLRIRKCFGIRQHHKITGLLLPEDLKRFL 287
Cdd:cd03724     3 PSSLCQLCRLCIRNYIGRSRLHLIPQLQLPTLLKNFL 39
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 130-231 7.41e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.20  E-value: 7.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751 130 LASPIHEAAKRGHAKCIESLAAHGANIDYNISHLGTPLYVACKNQQVDCAKKLLESGASVN-QGKGSDSPLHVVARMSSG 208
Cdd:PTZ00322   82 LTVELCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTlLDKDGKTPLELAEENGFR 161

                          90       100       110
                  ....*....|....*....|....*....|
gi 1046907751 209 ELVHLLM-------DFGANAQTKNADGKRP 231
Cdd:PTZ00322  162 EVVQLLSrhsqchfELGANAKPDSFTGKPP 191
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 249-289 1.20e-05

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 41.77  E-value: 1.20e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1046907751 249 EGPLSLMQLCRLRIRKCFGIRQHHKITGLLLPEDLKRFLLH 289
Cdd:cd03721     1 EPPRPLAHLCRLKVRTLIGINRIKLIDTLPLPPRLIRYLNH 41
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 36-231 2.34e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 45.34  E-value: 2.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  36 LHDAAIHGRLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCATVLISHGAQVNGMTIDWRTPLFNACVSGSQDCVN 115
Cdd:PHA02874  128 LHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIK 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751 116 LLLQHGAAPHPESDLA-SPIHEAAKrgHAKCIESLAAHGANIDYNISHLGTPLYVACKNQ-QVDCAKKLLESGA--SVNQ 191
Cdd:PHA02874  208 LLIDHGNHIMNKCKNGfTPLHNAII--HNRSAIELLINNASINDQDIDGSTPLHHAINPPcDIDIIDILLYHKAdiSIKD 285

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1046907751 192 GKGS---DSPLHVVARMSsgelvhLLMDFGANAQTKNADGKRP 231
Cdd:PHA02874  286 NKGEnpiDTAFKYINKDP------VIKDIIANAVLIKEADKLK 322
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 251-288 2.44e-05

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 40.89  E-value: 2.44e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1046907751 251 PLSLMQLCRLRIRKCFGIRQHHKITGLLLPEDLKRFLL 288
Cdd:cd03723     3 PRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLL 40
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 251-289 3.63e-05

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 40.10  E-value: 3.63e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1046907751 251 PLSLMQLCRLRIRKCFGIRQHHKITGLLLPEDLKRFLLH 289
Cdd:cd03720     3 PRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLH 41
Ank_4 pfam13637
Ankyrin repeats (many copies);
98-147 5.46e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.95  E-value: 5.46e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1046907751  98 WRTPLFNACVSGSQDCVNLLLQHGAAP-HPESDLASPIHEAAKRGHAKCIE 147
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADInAVDGNGETALHFAASNGNVEVLK 51
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 249-288 5.79e-05

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 39.50  E-value: 5.79e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1046907751 249 EGPLSLMQLCRLRIRKCFGIrqhHKITGLLLPEDLKRFLL 288
Cdd:cd03717     1 TSVRSLQHLCRFVIRQCTRR---DLIDQLPLPRRLKDYLK 37
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 251-287 5.99e-05

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 39.55  E-value: 5.99e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1046907751 251 PLSLMQLCRLRIRKCFGIRQHHKITGLLLPEDLKRFL 287
Cdd:cd03743     3 PLPLMDLCRRSARQALGRHRLHHIQSLPLPQTLKNYL 39
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 34-122 1.82e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 42.64  E-value: 1.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  34 SPLHDAAIHGRLLTLRNLISQGWPVNIITADHVSPLHEACLrgHLSCATVLISHGAQVNGMTIDWRTPLFNA----Cvsg 109
Cdd:PHA02874  192 SPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII--HNRSAIELLINNASINDQDIDGSTPLHHAinppC--- 266

                          90
                  ....*....|...
gi 1046907751 110 SQDCVNLLLQHGA 122
Cdd:PHA02874  267 DIDIIDILLYHKA 279
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 35-172 3.55e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 41.87  E-value: 3.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  35 PLHDAAIHGRLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCATVLISHGAQVNGMTIDWRTPLFNACVSgSQDCV 114
Cdd:PHA02874  160 PIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIH-NRSAI 238

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1046907751 115 NLLLQHGAAPHPESDLASPIHEAAKRGHAK-CIESLAAHGANIDYNISHLGTPLYVACK 172
Cdd:PHA02874  239 ELLINNASINDQDIDGSTPLHHAINPPCDIdIIDILLYHKADISIKDNKGENPIDTAFK 297
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 249-289 8.31e-04

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 36.75  E-value: 8.31e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1046907751 249 EGPLSLMQLCRLRIRKCFG---IRQHHKITGLLLPEDLKRFLLH 289
Cdd:cd03730     1 TNPRSLKHLCRLKIRACMGrlrLRCPVFMSFLPLPNRLKAYILY 44
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
 251-289 9.64e-04

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 36.11  E-value: 9.64e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1046907751 251 PLSLMQLCRLRIRKCFGIRQHHKITGLLLPEDLKRFLLH 289
Cdd:cd03744     3 PLPLMDLCRRSVRLALGRERLSEIHTLPLPASLKNYLLY 41
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 32-122 1.10e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.43  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  32 DWSPLHDAAIHGRLLTLRNLISQGWPVNIITADHVSPLHEA-CLRGHLSCATVLISHGAQVNGMTIDWRTPLFNACVSGS 110
Cdd:PHA02876  375 DKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNC 454

                          90
                  ....*....|...
gi 1046907751 111 Q-DCVNLLLQHGA 122
Cdd:PHA02876  455 KlDVIEMLLDNGA 467
Ank_4 pfam13637
Ankyrin repeats (many copies);
165-214 1.14e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.48  E-value: 1.14e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1046907751 165 TPLYVACKNQQVDCAKKLLESGASVN-QGKGSDSPLHVVARMSSGELVHLL 214
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINaVDGNGETALHFAASNGNVEVLKLL 53
PHA03095 PHA03095
ankyrin-like protein; Provisional
 114-233 1.50e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 39.62  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751 114 VNLLLQHGAAPHPESDLAS-PIHEAAKRGHAKC---IESLAAHGANIDYNISHLGTPL-YVACKNQQVDCAKKLLESGAS 188
Cdd:PHA03095   30 VRRLLAAGADVNFRGEYGKtPLHLYLHYSSEKVkdiVRLLLEAGADVNAPERCGFTPLhLYLYNATTLDVIKLLIKAGAD 109

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1046907751 189 VN-QGKGSDSPLHVVArmsSGELVH-----LLMDFGANAQTKNADGKRPVD 233
Cdd:PHA03095  110 VNaKDKVGRTPLHVYL---SGFNINpkvirLLLRKGADVNALDLYGMTPLA 157
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 165-190 1.77e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.26  E-value: 1.77e-03
                           10        20
                   ....*....|....*....|....*.
gi 1046907751  165 TPLYVACKNQQVDCAKKLLESGASVN 190
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 245-288 3.02e-03

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 34.96  E-value: 3.02e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1046907751  245 FLQREGPLSLMQLCRLRIRKCFGIRQhhkITGLLLPEDLKRFLL 288
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRTDQ---IKTLPLPPKLKDYLS 41
PHA03095 PHA03095
ankyrin-like protein; Provisional
 44-231 4.02e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 38.47  E-value: 4.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  44 RLLTLRNLISQGWPVNIITADHVSPLHeacLRGHLSCATV------LISHGAQVNGMTIDWRTPLF----NACVsgsQDC 113
Cdd:PHA03095   26 TVEEVRRLLAAGADVNFRGEYGKTPLH---LYLHYSSEKVkdivrlLLEAGADVNAPERCGFTPLHlylyNATT---LDV 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751 114 VNLLLQHGAAPHPESDLA-SPIHE--AAKRGHAKCIESLAAHGANIDYNISHLGTPLYVACKNQQVDCA--KKLLESGAS 188
Cdd:PHA03095  100 IKLLIKAGADVNAKDKVGrTPLHVylSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNANVEllRLLIDAGAD 179

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1046907751 189 V----NQGkgsDSPLHVVARM--SSGELVHLLMDFGANAQTKNADGKRP 231
Cdd:PHA03095  180 VyavdDRF---RSLLHHHLQSfkPRARIVRELIRAGCDPAATDMLGNTP 225
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 100-173 4.17e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 38.04  E-value: 4.17e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046907751 100 TPLFNACVSGSQDCVNLLLQHGAAPHPESDLA--SPIHEAAKRGHAKCIESLAAHGANIDYNISHLGTPLYVA---CKN 173
Cdd:PHA02884   72 NPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAkiTPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIELAlmiCNN 150
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 98-223 4.45e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 38.52  E-value: 4.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  98 WRTPLFNACVSGS-QDCVNLLLQHGAAPHPESDLaspIHEAAKRGHAKCIESL----AAHGANIDYNI---------SHL 163
Cdd:TIGR00870  52 GRSALFVAAIENEnLELTELLLNLSCRGAVGDTL---LHAISLEYVDAVEAILlhllAAFRKSGPLELandqytsefTPG 128

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1046907751 164 GTPLYVACKNQQVDCAKKLLESGASVN-----------QGKG----SDSPLHVVARMSSGELVHLLMDFGANAQT 223
Cdd:TIGR00870 129 ITALHLAAHRQNYEIVKLLLERGASVParacgdffvksQGVDsfyhGESPLNAAACLGSPSIVALLSEDPADILT 203
PHA03095 PHA03095
ankyrin-like protein; Provisional
 47-190 4.59e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 38.47  E-value: 4.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046907751  47 TLRNLISQGWPVNIITADHVSPLHeACLRGH-LSCATV--LISHGAQVNGMTIDWRTPLFNACVS--GSQDCVNLLLQHG 121
Cdd:PHA03095  134 VIRLLLRKGADVNALDLYGMTPLA-VLLKSRnANVELLrlLIDAGADVYAVDDRFRSLLHHHLQSfkPRARIVRELIRAG 212

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1046907751 122 AAPHPESDLA-SPIHEAAKRGHAKC--IESLAAHGANIDYNISHLGTPLYVA-CKNQQVDCAkKLLESGASVN 190
Cdd:PHA03095  213 CDPAATDMLGnTPLHSMATGSSCKRslVLPLLIAGISINARNRYGQTPLHYAaVFNNPRACR-RLIALGADIN 284
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 179-234 5.01e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 38.34  E-value: 5.01e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1046907751 179 AKKLLESGASVN-QGKGSDSPLHVVARMSSGELVHLLMDFGANAQTKNADGKRPVDL 234
Cdd:PTZ00322   98 ARILLTGGADPNcRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLEL 154
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 64-92 8.90e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 33.33  E-value: 8.90e-03
                           10        20
                   ....*....|....*....|....*....
gi 1046907751   64 DHVSPLHEACLRGHLSCATVLISHGAQVN 92
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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