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Conserved domains on  [gi|1039770402|ref|XP_017176130|]
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citron Rho-interacting kinase isoform X23 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CNH smart00036
Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;
1200-1496 1.49e-78

Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;


:

Pssm-ID: 214481  Cd Length: 302  Bit Score: 262.29  E-value: 1.49e-78
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  1200 DMNCTLPFSDQ--VVLVGTEEGLYALNVLK--NSLTHIPGIGAVFQIYIIKDLEKLLMIAGE---ERALCLVDVKKVKQS 1272
Cdd:smart00036    2 TAKWNHPITCDgkWLLVGTEEGLYVLNISDqpGTLEKLIGRRSVTQIWVLEENNVLLMISGKkpqLYSHPLSALVEKKEA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  1273 LAQSHLPAQPDVSPNiFEAVKGCHLFAAGKIENSLCICAAMPSKVVIL-RYNDNLSKYCIR-----KEIETSEPCSCIHF 1346
Cdd:smart00036   82 LGSARLVIRKNVLTK-IPDVKGCHLCAVVNGKRSLFLCVALQSSVVLLqWYNPLKKFKLFKskflfPLISPVPVFVELVS 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  1347 TNY---SILIGTNKfYEIDMKQYTLDeFLDKNDHSLAPAVFASSSNSFPVSIVQANsagqreEYLLCFHEFGVFVDSYG- 1422
Cdd:smart00036  161 SSFerpGICIGSDK-GGGDVVQFHES-LVSKEDLSLPFLSEETSLKPISVVQVPRD------EVLLCYDEFGVFVNLYGk 232

                           250       260       270       280       290       300       310
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039770402  1423 RRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSLGSPARAylEIPNPRYLGPaiSSGAIYLASSY 1496
Cdd:smart00036  233 RRSRNPILHWEFMPESFAYHSPYLLAFHDNGIEIRSIKTGELLQELADR--ETRKIRLLGS--SDRKILLSSSP 302
CRIK cd20814
protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) ...
 951-1006 3.88e-38

protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins; CRIK, also called serine/threonine-protein kinase 21, is an effector of the small GTPase Rho. It plays an important function during cytokinesis and affects its contractile process. CRIK-deficient mice show severe ataxia and epilepsy as a result of abnormal cytokinesis and massive apoptosis in neuronal precursors. A Down syndrome critical region protein TTC3 interacts with CRIK and inhibits CRIK-dependent neuronal differentiation and neurite extension. CRIK contains a catalytic domain, a central coiled-coil domain, and a C-terminal region containing a Rho-binding domain (RBD), a zinc finger (C1 domain), and a pleckstrin homology (PH) domain, in addition to other motifs. This model corresponds to C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


:

Pssm-ID: 410364  Cd Length: 56  Bit Score: 136.61  E-value: 3.88e-38
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770402  951 HNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLP 1006
Cdd:cd20814      1 HNIPHRFTTGLNMRATKCAVCLDGVPFGRQASKCSECGIVCHPKCSSSLPNTCGLP 56
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 72-786 1.06e-24

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 112.84  E-value: 1.06e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   72 EDDKALQLLHDIREQSRKLQEIKEQ--------------EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAA 137
Cdd:TIGR02168  197 ELERQLKSLERQAEKAERYKELKAElrelelallvlrleELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEV 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  138 EEFKRKANECQHKL--------------MKAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNI 203
Cdd:TIGR02168  277 SELEEEIEELQKELyalaneisrleqqkQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESL 356

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  204 RQAKERAERELEKLHNR----EDSSEGIKKKLVEAEERRHSLENKVKRLET----MERRENRLKDDIQTKSEQIQ--QMA 273
Cdd:TIGR02168  357 EAELEELEAELEELESRleelEEQLETLRSKVAQLELQIASLNNEIERLEArlerLEDRRERLQQEIEELLKKLEeaELK 436

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  274 DKILELEEKHREAQVSAQHLEVH------LKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQK 347
Cdd:TIGR02168  437 ELQAELEELEEELEELQEELERLeealeeLREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQS 516

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  348 AM---INAMDSKIRSLEQRIVELSEAnkLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIS 424
Cdd:TIGR02168  517 GLsgiLGVLSELISVDEGYEAAIEAA--LGGRLQAVVVENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREIL 594

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  425 HQDHSDKSRLLELETRLREVSL------------EHEEQKLELKRQL------------------------TELQLSLQE 468
Cdd:TIGR02168  595 KNIEGFLGVAKDLVKFDPKLRKalsyllggvlvvDDLDNALELAKKLrpgyrivtldgdlvrpggvitggsAKTNSSILE 674

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  469 RESQLTALQAARAALESQLRQAKteleettaeaeeeiQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNN 548
Cdd:TIGR02168  675 RRREIEELEEKIEELEEKIAELE--------------KALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEA 740

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  549 QNFYLSKQLDEASGANDEIVQLRSEVDhLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDEL 628
Cdd:TIGR02168  741 EVEQLEERIAQLSKELTELEAEIEELE-ERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEA 819

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  629 LEKERQWEAWRSVLGDEKSQFECRVRELQRM-LDTEKQSRARADQRITESRQvvELAVKEHKAEILALQQALKEQKLKAE 707
Cdd:TIGR02168  820 ANLRERLESLERRIAATERRLEDLEEQIEELsEDIESLAAEIEELEELIEEL--ESELEALLNERASLEEALALLRSELE 897

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  708 SLSDKLNDLEKKHAMLEMNARSLQQKLETER----ELKQRLLEEQAKL--QQQMDLQ--KNHIFRLTQGLQEALDRADLL 779
Cdd:TIGR02168  898 ELSEELRELESKRSELRRELEELREKLAQLElrleGLEVRIDNLQERLseEYSLTLEeaEALENKIEDDEEEARRRLKRL 977


                   ....*..
gi 1039770402  780 KTERSDL 786
Cdd:TIGR02168  978 ENKIKEL 984
PH pfam00169
PH domain; PH stands for pleckstrin homology.
 1036-1155 7.52e-08

PH domain; PH stands for pleckstrin homology.


:

Pssm-ID: 459697 [Multi-domain]  Cd Length: 105  Bit Score: 52.18  E-value: 7.52e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402 1036 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVeefelclpdGDVSIHGAVgASELANTAKADVPY 1115
Cdd:pfam00169    1 VVKEGWLLKKGGGKKK--SWKKRYFVLFDGSLLYYKDDKSGKSKEPK---------GSISLSGCE-VVEVVASDSPKRKF 68

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1039770402 1116 ILKMESHPHTtcwPGRTLYLLAPSFPDKQRWVTALESVVA 1155
Cdd:pfam00169   69 CFELRTGERT---GKRTYLLQAESEEERKDWIKAIQSAIR 105
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 666-943 3.05e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


:

Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 51.37  E-value: 3.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  666 SRARADQRITESRQvvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLET-ERELKQR- 743
Cdd:COG3883     10 TPAFADPQIQAKQK----ELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEaEAEIEERr 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  744 -LLEEQAKLQQQMDLQKNHIFRLT--QGLQEALDRADLLKTErsdleyqleniqvlyshekvkmegtISQQTKLIDFLQA 820
Cdd:COG3883     86 eELGERARALYRSGGSVSYLDVLLgsESFSDFLDRLSALSKI-------------------------ADADADLLEELKA 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  821 KMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPA 900
Cdd:COG3883    141 DKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAA 220

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 1039770402  901 TARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKESSTPEEFSR 943
Cdd:COG3883    221 AAAAAAAAAAAAAAAAAAAAAAAASAAGAGAAGAAGAAAGSAG 263
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 1512-1603 1.32e-05

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 50.07  E-value: 1.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402 1512 ESGTEQHRVPSTSRSSPNKRGPP--TYNEHITKR--------------VASSPAPPEGPSHPREPSTPHRYRDREGRTEL 1575
Cdd:PTZ00449   527 KEGEEGEHEDSKESDEPKEGGKPgeTKEGEVGKKpgpakehkpskiptLSKKPEFPKDPKHPKDPEEPKKPKRPRSAQRP 606

                           90       100       110
                   ....*....|....*....|....*....|
gi 1039770402 1576 RRDKSPGRP--LEREKSPGRMLSTRRERSP 1603
Cdd:PTZ00449   607 TRPKSPKLPelLDIPKSPKRPESPKSPKRP 636
 
Name Accession Description Interval E-value
CNH smart00036
Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;
1200-1496 1.49e-78

Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;


Pssm-ID: 214481  Cd Length: 302  Bit Score: 262.29  E-value: 1.49e-78
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  1200 DMNCTLPFSDQ--VVLVGTEEGLYALNVLK--NSLTHIPGIGAVFQIYIIKDLEKLLMIAGE---ERALCLVDVKKVKQS 1272
Cdd:smart00036    2 TAKWNHPITCDgkWLLVGTEEGLYVLNISDqpGTLEKLIGRRSVTQIWVLEENNVLLMISGKkpqLYSHPLSALVEKKEA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  1273 LAQSHLPAQPDVSPNiFEAVKGCHLFAAGKIENSLCICAAMPSKVVIL-RYNDNLSKYCIR-----KEIETSEPCSCIHF 1346
Cdd:smart00036   82 LGSARLVIRKNVLTK-IPDVKGCHLCAVVNGKRSLFLCVALQSSVVLLqWYNPLKKFKLFKskflfPLISPVPVFVELVS 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  1347 TNY---SILIGTNKfYEIDMKQYTLDeFLDKNDHSLAPAVFASSSNSFPVSIVQANsagqreEYLLCFHEFGVFVDSYG- 1422
Cdd:smart00036  161 SSFerpGICIGSDK-GGGDVVQFHES-LVSKEDLSLPFLSEETSLKPISVVQVPRD------EVLLCYDEFGVFVNLYGk 232

                           250       260       270       280       290       300       310
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039770402  1423 RRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSLGSPARAylEIPNPRYLGPaiSSGAIYLASSY 1496
Cdd:smart00036  233 RRSRNPILHWEFMPESFAYHSPYLLAFHDNGIEIRSIKTGELLQELADR--ETRKIRLLGS--SDRKILLSSSP 302
CNH pfam00780
CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished ...
 1208-1460 5.07e-68

CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.


Pssm-ID: 459938  Cd Length: 261  Bit Score: 230.21  E-value: 5.07e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402 1208 SDQVVLVGTEEGLYALNV-LKNSLTHIPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKkvkqSLAQSHLPAQPDVSP 1286
Cdd:pfam00780    1 GGQNLLLGTEEGLYVLNRsGPREPVRIIDKKRVTQLAVLEEFNLLLLLSGKDKRLYVYPLS----ALDSREENDRKDAAK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402 1287 NIFEAVKGCHLFAAGKIENSLCICAAMPSKVVILRYNDNLS-KYCIRKEIETSEPCSCIHFTNYSILIGTNKFYE-IDMK 1364
Cdd:pfam00780   77 NKLPETKGCHFFKVGRHSNGRFLVVAVKRTIKLLEWYEPLLdKFRKFKEFYLPSPPVSIELLKSKLCVGCAKGFEiVSLD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402 1365 QYTLDEFLdkndhsLAPAVFASSSNSFPVSIVQANsagqREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREP 1444
Cdd:pfam00780  157 SKATESLL------TSLLFANRQENLKPLAVVRLD----RSEFLLCYNEFGVYVNLQGRRSRPWEIEWEGAPEAVAYLYP 226

                          250
                   ....*....|....*.
gi 1039770402 1445 YLFVTHFNSLEVIEIQ 1460
Cdd:pfam00780  227 YLLAFHDNFIEIRDVE 242
CRIK cd20814
protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) ...
 951-1006 3.88e-38

protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins; CRIK, also called serine/threonine-protein kinase 21, is an effector of the small GTPase Rho. It plays an important function during cytokinesis and affects its contractile process. CRIK-deficient mice show severe ataxia and epilepsy as a result of abnormal cytokinesis and massive apoptosis in neuronal precursors. A Down syndrome critical region protein TTC3 interacts with CRIK and inhibits CRIK-dependent neuronal differentiation and neurite extension. CRIK contains a catalytic domain, a central coiled-coil domain, and a C-terminal region containing a Rho-binding domain (RBD), a zinc finger (C1 domain), and a pleckstrin homology (PH) domain, in addition to other motifs. This model corresponds to C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410364  Cd Length: 56  Bit Score: 136.61  E-value: 3.88e-38
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770402  951 HNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLP 1006
Cdd:cd20814      1 HNIPHRFTTGLNMRATKCAVCLDGVPFGRQASKCSECGIVCHPKCSSSLPNTCGLP 56
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 72-786 1.06e-24

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 112.84  E-value: 1.06e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   72 EDDKALQLLHDIREQSRKLQEIKEQ--------------EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAA 137
Cdd:TIGR02168  197 ELERQLKSLERQAEKAERYKELKAElrelelallvlrleELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEV 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  138 EEFKRKANECQHKL--------------MKAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNI 203
Cdd:TIGR02168  277 SELEEEIEELQKELyalaneisrleqqkQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESL 356

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  204 RQAKERAERELEKLHNR----EDSSEGIKKKLVEAEERRHSLENKVKRLET----MERRENRLKDDIQTKSEQIQ--QMA 273
Cdd:TIGR02168  357 EAELEELEAELEELESRleelEEQLETLRSKVAQLELQIASLNNEIERLEArlerLEDRRERLQQEIEELLKKLEeaELK 436

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  274 DKILELEEKHREAQVSAQHLEVH------LKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQK 347
Cdd:TIGR02168  437 ELQAELEELEEELEELQEELERLeealeeLREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQS 516

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  348 AM---INAMDSKIRSLEQRIVELSEAnkLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIS 424
Cdd:TIGR02168  517 GLsgiLGVLSELISVDEGYEAAIEAA--LGGRLQAVVVENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREIL 594

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  425 HQDHSDKSRLLELETRLREVSL------------EHEEQKLELKRQL------------------------TELQLSLQE 468
Cdd:TIGR02168  595 KNIEGFLGVAKDLVKFDPKLRKalsyllggvlvvDDLDNALELAKKLrpgyrivtldgdlvrpggvitggsAKTNSSILE 674

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  469 RESQLTALQAARAALESQLRQAKteleettaeaeeeiQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNN 548
Cdd:TIGR02168  675 RRREIEELEEKIEELEEKIAELE--------------KALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEA 740

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  549 QNFYLSKQLDEASGANDEIVQLRSEVDhLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDEL 628
Cdd:TIGR02168  741 EVEQLEERIAQLSKELTELEAEIEELE-ERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEA 819

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  629 LEKERQWEAWRSVLGDEKSQFECRVRELQRM-LDTEKQSRARADQRITESRQvvELAVKEHKAEILALQQALKEQKLKAE 707
Cdd:TIGR02168  820 ANLRERLESLERRIAATERRLEDLEEQIEELsEDIESLAAEIEELEELIEEL--ESELEALLNERASLEEALALLRSELE 897

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  708 SLSDKLNDLEKKHAMLEMNARSLQQKLETER----ELKQRLLEEQAKL--QQQMDLQ--KNHIFRLTQGLQEALDRADLL 779
Cdd:TIGR02168  898 ELSEELRELESKRSELRRELEELREKLAQLElrleGLEVRIDNLQERLseEYSLTLEeaEALENKIEDDEEEARRRLKRL 977


                   ....*..
gi 1039770402  780 KTERSDL 786
Cdd:TIGR02168  978 ENKIKEL 984
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 236-805 8.77e-23

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 106.17  E-value: 8.77e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  236 ERRHSLENKvkrLETMERRENRLKDDIQTKSEQIQQMAD--------KILELEEKHREAQVSAQHLEvHLKQKEQHYEEK 307
Cdd:COG1196    172 ERKEEAERK---LEATEENLERLEDILGELERQLEPLERqaekaeryRELKEELKELEAELLLLKLR-ELEAELEELEAE 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  308 IKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAansslftQRNMKA 387
Cdd:COG1196    248 LEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRREL-------EERLEE 320

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  388 QEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVS----------LEHEEQKLELKR 457
Cdd:COG1196    321 LEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEeeleelaeelLEALRAAAELAA 400

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  458 QLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLN 537
Cdd:COG1196    401 QLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALA 480

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  538 QLTEDNAELNNQNFYLSKQLDEASGAND----------------EIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDL 601
Cdd:COG1196    481 ELLEELAEAAARLLLLLEAEADYEGFLEgvkaalllaglrglagAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAA 560

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  602 QTMEALKTT----CTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITES 677
Cdd:COG1196    561 AAIEYLKAAkagrATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAV 640

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  678 RQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDL 757
Cdd:COG1196    641 TLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEE 720

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*...
gi 1039770402  758 QKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKME 805
Cdd:COG1196    721 LEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERE 768
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 22-890 9.08e-20

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 96.58  E-value: 9.08e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   22 EVEAVLSQKEVElkasetqRSLLEQDLATYItecssLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQ 101
Cdd:pfam02463  143 KIEIIAMMKPER-------RLEIEEEAAGSR-----LKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKAL 210

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  102 VEEMRLMMNQLEEDLVSARRRSDLYESELRES----RLAAEEFKRKANECQHKLMKAKDQGKPEVGEYSKLEKINAEQQL 177
Cdd:pfam02463  211 EYYQLKEKLELEEEYLLYLDYLKLNEERIDLLqellRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKL 290

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  178 KIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENR 257
Cdd:pfam02463  291 LAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQ 370

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  258 LKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAH 337
Cdd:pfam02463  371 LEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEK 450

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  338 EKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELrqqkfyletqAGKLEAQNRKLE 417
Cdd:pfam02463  451 EELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSG----------LKVLLALIKDGV 520

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  418 EQLEKISHQDHSDKSRLLELETRLREVSLehEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEET 497
Cdd:pfam02463  521 GGRIISAHGRLGDLGVAVENYKVAISTAV--IVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLE 598

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  498 TAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHL 577
Cdd:pfam02463  599 IDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEI 678

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  578 RREITEREMQLtsQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQ 657
Cdd:pfam02463  679 QELQEKAESEL--AKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSR 756

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  658 RMLDTEKQSRARADQRITEsrqvvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETE 737
Cdd:pfam02463  757 LKKEEKEEEKSELSLKEKE-------LAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEK 829

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  738 RELKQRLLEEQAKLQQQMDLQKNhifrlTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDF 817
Cdd:pfam02463  830 IKEEELEELALELKEEQKLEKLA-----EEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEE 904

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039770402  818 LQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKA 890
Cdd:pfam02463  905 ESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNL 977
PTZ00121 PTZ00121
MAEBL; Provisional
 12-787 7.51e-19

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 94.05  E-value: 7.51e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   12 EMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQdlatyitecsslKRSLEQARMEVSQEDDKALQLLHDIR--EQSRK 89
Cdd:PTZ00121  1068 QDEGLKPSYKDFDFDAKEDNRADEATEEAFGKAEE------------AKKTETGKAEEARKAEEAKKKAEDARkaEEARK 1135

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   90 LQEIKEQEYQAQVEEMRlmmnqleeDLVSARRRSDLYESElrESRLAAE----EFKRKANECQ--HKLMKAKDQGKPEvg 163
Cdd:PTZ00121  1136 AEDARKAEEARKAEDAK--------RVEIARKAEDARKAE--EARKAEDakkaEAARKAEEVRkaEELRKAEDARKAE-- 1203

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  164 EYSKLEKINAEQQLKIQELQEKLEkAVKASTEATELLQNIRQA-KERAERELEKLHNREDSSEGIKKKLVEAEERRHSLE 242
Cdd:PTZ00121  1204 AARKAEEERKAEEARKAEDAKKAE-AVKKAEEAKKDAEEAKKAeEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADE 1282

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  243 nkVKRLETMERRENRLKDDIQTKSEQIQQMAD---KILELEEKHREAQVSAQHLEVHLKQKEQHYEEKiKVLDNQIKKDL 319
Cdd:PTZ00121  1283 --LKKAEEKKKADEAKKAEEKKKADEAKKKAEeakKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAA-KAEAEAAADEA 1359

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  320 ADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQK 399
Cdd:PTZ00121  1360 EAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKK 1439

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  400 FYLETQAGKLEA---QNRKLEEQLEKISHQDHSDKSRLLELETRLREvslEHEEQKLELKRQLTELQLSLQERESQLTAL 476
Cdd:PTZ00121  1440 AEEAKKADEAKKkaeEAKKAEEAKKKAEEAKKADEAKKKAEEAKKAD---EAKKKAEEAKKKADEAKKAAEAKKKADEAK 1516

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  477 QAARAALESQLRQAKTELeettaeaeeeiQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQ 556
Cdd:PTZ00121  1517 KAEEAKKADEAKKAEEAK-----------KADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEE 1585

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  557 LDEASGANDEIVQLRSEvdhlrREITEREMQLTSQKQAQLSAPDLQTMEALKTTCTMLEEQVLDlEALNDELLEKERQWE 636
Cdd:PTZ00121  1586 AKKAEEARIEEVMKLYE-----EEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAE-EKKKAEELKKAEEEN 1659

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  637 AWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQ---KLKAESLSDKL 713
Cdd:PTZ00121  1660 KIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEeenKIKAEEAKKEA 1739

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  714 NDLEKK---------------HAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADL 778
Cdd:PTZ00121  1740 EEDKKKaeeakkdeeekkkiaHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNL 1819


                   ....*....
gi 1039770402  779 LKTERSDLE 787
Cdd:PTZ00121  1820 VINDSKEME 1828
C1 smart00109
Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol ...
 955-1003 1.79e-10

Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol esters and diacylglycerol. Some bind RasGTP. Zinc-binding domains.


Pssm-ID: 197519  Cd Length: 50  Bit Score: 57.48  E-value: 1.79e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 1039770402   955 HRFNVGLNMRATKCAVCLDTVHFGR-QASKCLECQVMCHPKCSTCLPATC 1003
Cdd:smart00109    1 HKHVFRTFTKPTFCCVCRKSIWGSFkQGLRCSECKVKCHKKCADKVPKAC 50
ROM1 COG5422
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction ...
 1208-1459 2.11e-09

RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms];


Pssm-ID: 227709 [Multi-domain]  Cd Length: 1175  Bit Score: 62.60  E-value: 2.11e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402 1208 SDQVVLVGTEEGLYALNVLKNS--------LTHIPGIGavfQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLp 1279
Cdd:COG5422    868 SGRKLLTGTNKGLYISNRKDNVnrfnkpidLLQEPNIS---QIIVIEEYKLMLLLSDKKLYSCPLDVIDASTEENVKKS- 943

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402 1280 aqpDVSPNIFEAVK-----GCHLFAAGKiENSLCICAAMPSKVVILRYNDN------LSKYCIRKEIETSEPCScIHFTN 1348
Cdd:COG5422    944 ---RIVNGHVSFFKqgfcnGKRLVCAVK-SSSLSATLAVIEAPLALKKNKSgnlkkaLTIELSTELYVPSEPLS-VHFLK 1018

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402 1349 YSILIGTNKFYEI-DMKQYTLDEFLDKNDHSlaPAVFASSSNSFPVSIVQANSagqreEYLLCFHEFGVFVDSYGRRSRT 1427
Cdd:COG5422   1019 NKLCIGCKKGFEIvSLENLRTESLLNPADTS--PLFFEKKENTKPIAIFRVSG-----EFLLCYSEFAFFVNDQGWRKRT 1091

                          250       260       270
                   ....*....|....*....|....*....|...
gi 1039770402 1428 DDL-KWSRLPLAFAYREPYlfVTHFNSlEVIEI 1459
Cdd:COG5422   1092 SWIfHWEGEPQEFALSYPY--ILAFEP-NFIEI 1121
PH pfam00169
PH domain; PH stands for pleckstrin homology.
 1036-1155 7.52e-08

PH domain; PH stands for pleckstrin homology.


Pssm-ID: 459697 [Multi-domain]  Cd Length: 105  Bit Score: 52.18  E-value: 7.52e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402 1036 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVeefelclpdGDVSIHGAVgASELANTAKADVPY 1115
Cdd:pfam00169    1 VVKEGWLLKKGGGKKK--SWKKRYFVLFDGSLLYYKDDKSGKSKEPK---------GSISLSGCE-VVEVVASDSPKRKF 68

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1039770402 1116 ILKMESHPHTtcwPGRTLYLLAPSFPDKQRWVTALESVVA 1155
Cdd:pfam00169   69 CFELRTGERT---GKRTYLLQAESEEERKDWIKAIQSAIR 105
PH smart00233
Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The ...
 1036-1155 2.81e-07

Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids.


Pssm-ID: 214574 [Multi-domain]  Cd Length: 102  Bit Score: 50.24  E-value: 2.81e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  1036 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELClpdgDVSIhgavgaSELANTAKADVPY 1115
Cdd:smart00233    1 VIKEGWLYKKSGGGKK--SWKKRYFVLFNSTLLYYKSKKDKKSYKPKGSIDLS----GCTV------REAPDPDSSKKPH 68

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|
gi 1039770402  1116 ILKMeshphtTCWPGRTLYLLAPSFPDKQRWVTALESVVA 1155
Cdd:smart00233   69 CFEI------KTSDRKTLLLQAESEEEREKWVEALRKAIA 102
C1_1 pfam00130
Phorbol esters/diacylglycerol binding domain (C1 domain); This domain is also known as the ...
 950-1005 1.94e-06

Phorbol esters/diacylglycerol binding domain (C1 domain); This domain is also known as the Protein kinase C conserved region 1 (C1) domain.


Pssm-ID: 395079  Cd Length: 53  Bit Score: 46.28  E-value: 1.94e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039770402  950 HHNIPHRFNvglnmRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCGL 1005
Cdd:pfam00130    1 HHFVHRNFK-----QPTFCDHCGEFLwGLGKQGLKCSWCKLNVHKRCHEKVPPECGC 52
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 666-943 3.05e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 51.37  E-value: 3.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  666 SRARADQRITESRQvvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLET-ERELKQR- 743
Cdd:COG3883     10 TPAFADPQIQAKQK----ELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEaEAEIEERr 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  744 -LLEEQAKLQQQMDLQKNHIFRLT--QGLQEALDRADLLKTErsdleyqleniqvlyshekvkmegtISQQTKLIDFLQA 820
Cdd:COG3883     86 eELGERARALYRSGGSVSYLDVLLgsESFSDFLDRLSALSKI-------------------------ADADADLLEELKA 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  821 KMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPA 900
Cdd:COG3883    141 DKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAA 220

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 1039770402  901 TARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKESSTPEEFSR 943
Cdd:COG3883    221 AAAAAAAAAAAAAAAAAAAAAAAASAAGAGAAGAAGAAAGSAG 263
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1512-1603 1.32e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 50.07  E-value: 1.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402 1512 ESGTEQHRVPSTSRSSPNKRGPP--TYNEHITKR--------------VASSPAPPEGPSHPREPSTPHRYRDREGRTEL 1575
Cdd:PTZ00449   527 KEGEEGEHEDSKESDEPKEGGKPgeTKEGEVGKKpgpakehkpskiptLSKKPEFPKDPKHPKDPEEPKKPKRPRSAQRP 606

                           90       100       110
                   ....*....|....*....|....*....|
gi 1039770402 1576 RRDKSPGRP--LEREKSPGRMLSTRRERSP 1603
Cdd:PTZ00449   607 TRPKSPKLPelLDIPKSPKRPESPKSPKRP 636
PH_ROCK cd01242
Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain; ROCK is ...
 1037-1082 7.00e-05

Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain; ROCK is a serine/threonine kinase that binds GTP-Rho. It consists of a kinase domain, a coiled coil region and a PH domain. The ROCK PH domain is interrupted by a C1 domain. ROCK plays a role in cellular functions, such as contraction, adhesion, migration, and proliferation and in the regulation of apoptosis. There are two ROCK isoforms, ROCK1 and ROCK2. In ROCK2 the Rho Binding Domain (RBD) and the PH domain work together in membrane localization with RBD receiving the RhoA signal and the PH domain receiving the phospholipid signal. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.


Pssm-ID: 269948  Cd Length: 110  Bit Score: 43.50  E-value: 7.00e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1039770402 1037 HLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPV 1082
Cdd:cd01242      2 RLEGWLSLPNKQNIRRHGWKKQYVVVSSKKILFYNSEQDKANSNPI 47
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 10-335 2.12e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 42.69  E-value: 2.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   10 EQEMTRLHRRVSEVEAVLSQKEvelKASETQRsllEQDLATYITEC-SSLKRSLEQARMEVSQEDdkaLQLLHDIREQSR 88
Cdd:NF033838   131 KKDTLEPGKKVAEATKKVEEAE---KKAKDQK---EEDRRNYPTNTyKTLELEIAESDVEVKKAE---LELVKEEAKEPR 201

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   89 KLQEIKEQEY-----QAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEE-------FKRKANECQHKLMKAKD 156
Cdd:NF033838   202 DEEKIKQAKAkveskKAEATRLEKIKTDREKAEEEAKRRADAKLKEAVEKNVATSEqdkpkrrAKRGVLGEPATPDKKEN 281

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  157 QGK---PEVGEYS------KLEKINAEQQLKIQELQEKLEK----------AVKASTEATELLQNIRQAKErAERELEKL 217
Cdd:NF033838   282 DAKssdSSVGEETlpspslKPEKKVAEAEKKVEEAKKKAKDqkeedrrnypTNTYKTLELEIAESDVKVKE-AELELVKE 360

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  218 HNREDSSEgikKKLVEAEERRHSLENKVKRLEtmerrenRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVhl 297
Cdd:NF033838   361 EAKEPRNE---EKIKQAKAKVESKKAEATRLE-------KIKTDRKKAEEEAKRKAAEEDKVKEKPAEQPQPAPAPQP-- 428

                          330       340       350
                   ....*....|....*....|....*....|....*...
gi 1039770402  298 kQKEQHYEEKIKVLDNQIKKDlaDKESLENMMQRHEEE 335
Cdd:NF033838   429 -EKPAPKPEKPAEQPKAEKPA--DQQAEEDYARRSEEE 463
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
 505-624 3.02e-03

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 41.59  E-value: 3.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  505 IQALTahrDEIQRKFDALRNSCT-VITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAN--DEIVQLRSEVDHLRREI 581
Cdd:cd22656    119 IKALL---DDLLKEAKKYQDKAAkVVDKLTDFENQTEKDQTALETLEKALKDLLTDEGGAIarKEIKDLQKELEKLNEEY 195

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1039770402  582 TER---EMQLTSQKQAQLSApDLQTMEALKTTCTMLEEQVLDLEAL 624
Cdd:cd22656    196 AAKlkaKIDELKALIADDEA-KLAAALRLIADLTAADTDLDNLLAL 240
 
Name Accession Description Interval E-value
CNH smart00036
Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;
1200-1496 1.49e-78

Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;


Pssm-ID: 214481  Cd Length: 302  Bit Score: 262.29  E-value: 1.49e-78
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  1200 DMNCTLPFSDQ--VVLVGTEEGLYALNVLK--NSLTHIPGIGAVFQIYIIKDLEKLLMIAGE---ERALCLVDVKKVKQS 1272
Cdd:smart00036    2 TAKWNHPITCDgkWLLVGTEEGLYVLNISDqpGTLEKLIGRRSVTQIWVLEENNVLLMISGKkpqLYSHPLSALVEKKEA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  1273 LAQSHLPAQPDVSPNiFEAVKGCHLFAAGKIENSLCICAAMPSKVVIL-RYNDNLSKYCIR-----KEIETSEPCSCIHF 1346
Cdd:smart00036   82 LGSARLVIRKNVLTK-IPDVKGCHLCAVVNGKRSLFLCVALQSSVVLLqWYNPLKKFKLFKskflfPLISPVPVFVELVS 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  1347 TNY---SILIGTNKfYEIDMKQYTLDeFLDKNDHSLAPAVFASSSNSFPVSIVQANsagqreEYLLCFHEFGVFVDSYG- 1422
Cdd:smart00036  161 SSFerpGICIGSDK-GGGDVVQFHES-LVSKEDLSLPFLSEETSLKPISVVQVPRD------EVLLCYDEFGVFVNLYGk 232

                           250       260       270       280       290       300       310
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039770402  1423 RRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSLGSPARAylEIPNPRYLGPaiSSGAIYLASSY 1496
Cdd:smart00036  233 RRSRNPILHWEFMPESFAYHSPYLLAFHDNGIEIRSIKTGELLQELADR--ETRKIRLLGS--SDRKILLSSSP 302
CNH pfam00780
CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished ...
 1208-1460 5.07e-68

CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.


Pssm-ID: 459938  Cd Length: 261  Bit Score: 230.21  E-value: 5.07e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402 1208 SDQVVLVGTEEGLYALNV-LKNSLTHIPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKkvkqSLAQSHLPAQPDVSP 1286
Cdd:pfam00780    1 GGQNLLLGTEEGLYVLNRsGPREPVRIIDKKRVTQLAVLEEFNLLLLLSGKDKRLYVYPLS----ALDSREENDRKDAAK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402 1287 NIFEAVKGCHLFAAGKIENSLCICAAMPSKVVILRYNDNLS-KYCIRKEIETSEPCSCIHFTNYSILIGTNKFYE-IDMK 1364
Cdd:pfam00780   77 NKLPETKGCHFFKVGRHSNGRFLVVAVKRTIKLLEWYEPLLdKFRKFKEFYLPSPPVSIELLKSKLCVGCAKGFEiVSLD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402 1365 QYTLDEFLdkndhsLAPAVFASSSNSFPVSIVQANsagqREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREP 1444
Cdd:pfam00780  157 SKATESLL------TSLLFANRQENLKPLAVVRLD----RSEFLLCYNEFGVYVNLQGRRSRPWEIEWEGAPEAVAYLYP 226

                          250
                   ....*....|....*.
gi 1039770402 1445 YLFVTHFNSLEVIEIQ 1460
Cdd:pfam00780  227 YLLAFHDNFIEIRDVE 242
CRIK cd20814
protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) ...
 951-1006 3.88e-38

protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins; CRIK, also called serine/threonine-protein kinase 21, is an effector of the small GTPase Rho. It plays an important function during cytokinesis and affects its contractile process. CRIK-deficient mice show severe ataxia and epilepsy as a result of abnormal cytokinesis and massive apoptosis in neuronal precursors. A Down syndrome critical region protein TTC3 interacts with CRIK and inhibits CRIK-dependent neuronal differentiation and neurite extension. CRIK contains a catalytic domain, a central coiled-coil domain, and a C-terminal region containing a Rho-binding domain (RBD), a zinc finger (C1 domain), and a pleckstrin homology (PH) domain, in addition to other motifs. This model corresponds to C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410364  Cd Length: 56  Bit Score: 136.61  E-value: 3.88e-38
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770402  951 HNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLP 1006
Cdd:cd20814      1 HNIPHRFTTGLNMRATKCAVCLDGVPFGRQASKCSECGIVCHPKCSSSLPNTCGLP 56
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 72-786 1.06e-24

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 112.84  E-value: 1.06e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   72 EDDKALQLLHDIREQSRKLQEIKEQ--------------EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAA 137
Cdd:TIGR02168  197 ELERQLKSLERQAEKAERYKELKAElrelelallvlrleELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEV 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  138 EEFKRKANECQHKL--------------MKAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNI 203
Cdd:TIGR02168  277 SELEEEIEELQKELyalaneisrleqqkQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESL 356

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  204 RQAKERAERELEKLHNR----EDSSEGIKKKLVEAEERRHSLENKVKRLET----MERRENRLKDDIQTKSEQIQ--QMA 273
Cdd:TIGR02168  357 EAELEELEAELEELESRleelEEQLETLRSKVAQLELQIASLNNEIERLEArlerLEDRRERLQQEIEELLKKLEeaELK 436

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  274 DKILELEEKHREAQVSAQHLEVH------LKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQK 347
Cdd:TIGR02168  437 ELQAELEELEEELEELQEELERLeealeeLREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQS 516

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  348 AM---INAMDSKIRSLEQRIVELSEAnkLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIS 424
Cdd:TIGR02168  517 GLsgiLGVLSELISVDEGYEAAIEAA--LGGRLQAVVVENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREIL 594

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  425 HQDHSDKSRLLELETRLREVSL------------EHEEQKLELKRQL------------------------TELQLSLQE 468
Cdd:TIGR02168  595 KNIEGFLGVAKDLVKFDPKLRKalsyllggvlvvDDLDNALELAKKLrpgyrivtldgdlvrpggvitggsAKTNSSILE 674

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  469 RESQLTALQAARAALESQLRQAKteleettaeaeeeiQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNN 548
Cdd:TIGR02168  675 RRREIEELEEKIEELEEKIAELE--------------KALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEA 740

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  549 QNFYLSKQLDEASGANDEIVQLRSEVDhLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDEL 628
Cdd:TIGR02168  741 EVEQLEERIAQLSKELTELEAEIEELE-ERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEA 819

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  629 LEKERQWEAWRSVLGDEKSQFECRVRELQRM-LDTEKQSRARADQRITESRQvvELAVKEHKAEILALQQALKEQKLKAE 707
Cdd:TIGR02168  820 ANLRERLESLERRIAATERRLEDLEEQIEELsEDIESLAAEIEELEELIEEL--ESELEALLNERASLEEALALLRSELE 897

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  708 SLSDKLNDLEKKHAMLEMNARSLQQKLETER----ELKQRLLEEQAKL--QQQMDLQ--KNHIFRLTQGLQEALDRADLL 779
Cdd:TIGR02168  898 ELSEELRELESKRSELRRELEELREKLAQLElrleGLEVRIDNLQERLseEYSLTLEeaEALENKIEDDEEEARRRLKRL 977


                   ....*..
gi 1039770402  780 KTERSDL 786
Cdd:TIGR02168  978 ENKIKEL 984
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 236-805 8.77e-23

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 106.17  E-value: 8.77e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  236 ERRHSLENKvkrLETMERRENRLKDDIQTKSEQIQQMAD--------KILELEEKHREAQVSAQHLEvHLKQKEQHYEEK 307
Cdd:COG1196    172 ERKEEAERK---LEATEENLERLEDILGELERQLEPLERqaekaeryRELKEELKELEAELLLLKLR-ELEAELEELEAE 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  308 IKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAansslftQRNMKA 387
Cdd:COG1196    248 LEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRREL-------EERLEE 320

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  388 QEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVS----------LEHEEQKLELKR 457
Cdd:COG1196    321 LEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEeeleelaeelLEALRAAAELAA 400

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  458 QLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLN 537
Cdd:COG1196    401 QLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALA 480

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  538 QLTEDNAELNNQNFYLSKQLDEASGAND----------------EIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDL 601
Cdd:COG1196    481 ELLEELAEAAARLLLLLEAEADYEGFLEgvkaalllaglrglagAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAA 560

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  602 QTMEALKTT----CTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITES 677
Cdd:COG1196    561 AAIEYLKAAkagrATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAV 640

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  678 RQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDL 757
Cdd:COG1196    641 TLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEE 720

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*...
gi 1039770402  758 QKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKME 805
Cdd:COG1196    721 LEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERE 768
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 173-793 9.97e-23

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 106.17  E-value: 9.97e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  173 AEQQLKIQELQEKLEKAvkastEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEerrhslenkvKRLETME 252
Cdd:COG1196    209 AEKAERYRELKEELKEL-----EAELLLLKLRELEAELEELEAELEELEAELEELEAELAELE----------AELEELR 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  253 RRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEvhlkQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRH 332
Cdd:COG1196    274 LELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELE----ERLEELEEELAELEEELEELEEELEELEEELEEA 349

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  333 EEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQ 412
Cdd:COG1196    350 EEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEA 429

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  413 NRKLEEQLEKISHQDHSDKSRLLELETR---LREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQ 489
Cdd:COG1196    430 LAELEEEEEEEEEALEEAAEEEAELEEEeeaLLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEG 509

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  490 AKTELEETTAEAEeeIQALTAHRDEIQRKFDALRnsctviTDLEEQLNQLTEDNAElnnqnfylskqldeasgandeivQ 569
Cdd:COG1196    510 VKAALLLAGLRGL--AGAVAVLIGVEAAYEAALE------AALAAALQNIVVEDDE-----------------------V 558

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  570 LRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALkttctmLEEQVLDLEALNDELLEKERQ----WEAWRSVLGDE 645
Cdd:COG1196    559 AAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGA------IGAAVDLVASDLREADARYYVlgdtLLGRTLVAARL 632

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  646 KSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEM 725
Cdd:COG1196    633 EAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEA 712

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770402  726 NARSLQQKLETERElKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENI 793
Cdd:COG1196    713 EEERLEEELEEEAL-EEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEAL 779
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 12-794 8.94e-22

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 103.21  E-value: 8.94e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   12 EMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVsqeddkaLQLLHDIREQSRKLQ 91
Cdd:TIGR02168  233 RLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKEL-------YALANEISRLEQQKQ 305

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   92 EIKEQEYQAQVEEMRLmmnqlEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLmkakdqgkpevgeySKLEKI 171
Cdd:TIGR02168  306 ILRERLANLERQLEEL-----EAQLEELESKLDELAEELAELEEKLEELKEELESLEAEL--------------EELEAE 366

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  172 NAEQQLKIQELQEKLEKAVKASTEATE-------LLQNIRQAKERAERELEKLHNrEDSSEGIKKKLVEAEERRHSLENK 244
Cdd:TIGR02168  367 LEELESRLEELEEQLETLRSKVAQLELqiaslnnEIERLEARLERLEDRRERLQQ-EIEELLKKLEEAELKELQAELEEL 445

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  245 VKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKD-----L 319
Cdd:TIGR02168  446 EEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSgilgvL 525

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  320 ADKESLENMMQRHEEEAHEK--GKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQ 397
Cdd:TIGR02168  526 SELISVDEGYEAAIEAALGGrlQAVVVENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAK 605

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  398 QKFYLETQAGKL---------------EAQN--RKLEEQLEKISHQDHSDKSR-LLELETRLREVSLEHEEQKL-ELKRQ 458
Cdd:TIGR02168  606 DLVKFDPKLRKAlsyllggvlvvddldNALElaKKLRPGYRIVTLDGDLVRPGgVITGGSAKTNSSILERRREIeELEEK 685

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  459 LTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQ 538
Cdd:TIGR02168  686 IEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEE 765

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  539 LTEDNAELNNQnfyLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSapdlqtmeaLKTTCTMLEEQV 618
Cdd:TIGR02168  766 LEERLEEAEEE---LAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAAN---------LRERLESLERRI 833

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  619 LDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESR---QVVELAVKEHKAEILAL 695
Cdd:TIGR02168  834 AATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRselEELSEELRELESKRSEL 913

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  696 QQALKEqklkaesLSDKLNDLEKKHAMLEMNARSLQQKLeteRELKQRLLEEQAKLQQQMDLQ----KNHIFRLTQGLQE 771
Cdd:TIGR02168  914 RRELEE-------LREKLAQLELRLEGLEVRIDNLQERL---SEEYSLTLEEAEALENKIEDDeeeaRRRLKRLENKIKE 983

                          810       820       830
                   ....*....|....*....|....*....|....*..
gi 1039770402  772 -------ALD-------RADLLKTERSDLEYQLENIQ 794
Cdd:TIGR02168  984 lgpvnlaAIEeyeelkeRYDFLTAQKEDLTEAKETLE 1020
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 174-886 2.35e-21

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 101.67  E-value: 2.35e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  174 EQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEkLHNREDSSEG--IKKKLVEAEERRHSLENKVKRletM 251
Cdd:TIGR02168  176 ETERKLERTRENLDRLEDILNELERQLKSLERQAEKAERYKE-LKAELRELELalLVLRLEELREELEELQEELKE---A 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  252 ERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQ---VSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENM 328
Cdd:TIGR02168  252 EEELEELTAELQELEEKLEELRLEVSELEEEIEELQkelYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESK 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  329 MQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKlaansslftqrnmkAQEEMISELRQQKFYLETQAGK 408
Cdd:TIGR02168  332 LDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLE--------------ELEEQLETLRSKVAQLELQIAS 397

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  409 LEAQNRKLEEQLEKISHQDHSDKSRLLELETRLrevsleHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLR 488
Cdd:TIGR02168  398 LNNEIERLEARLERLEDRRERLQQEIEELLKKL------EEAELKELQAELEELEEELEELQEELERLEEALEELREELE 471

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  489 QAKteleettaeaeeeiQALTAHRDEIQRkfdaLRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASgandEIV 568
Cdd:TIGR02168  472 EAE--------------QALDAAERELAQ----LQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLS----ELI 529

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  569 QLRSEvdhLRREITE-----REMQLTSQKQAQLSAPDLQTmEALKTTCTMLEEQVL---DLEALNDELLEKERQWEAWRS 640
Cdd:TIGR02168  530 SVDEG---YEAAIEAalggrLQAVVVENLNAAKKAIAFLK-QNELGRVTFLPLDSIkgtEIQGNDREILKNIEGFLGVAK 605

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  641 VLGDEKSQFEcrvRELQRMLD-----------TEKQSRARADQRIT-------ESRQVVELAVKEHKAEILALQQALKEQ 702
Cdd:TIGR02168  606 DLVKFDPKLR---KALSYLLGgvlvvddldnaLELAKKLRPGYRIVtldgdlvRPGGVITGGSAKTNSSILERRREIEEL 682

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  703 KLKAESLSDKLNDLEKKHAMLemnaRSLQQKLETERELKQRLLEEqakLQQQMDLQKNHIFRLTQGLQEALDRADLLKTE 782
Cdd:TIGR02168  683 EEKIEELEEKIAELEKALAEL----RKELEELEEELEQLRKELEE---LSRQISALRKDLARLEAEVEQLEERIAQLSKE 755

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  783 RSDLEYQLEniqvLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKA 862
Cdd:TIGR02168  756 LTELEAEIE----ELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLER 831

                          730       740
                   ....*....|....*....|....
gi 1039770402  863 RCAELEEALQKTRIELRSAREEAA 886
Cdd:TIGR02168  832 RIAATERRLEDLEEQIEELSEDIE 855
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2-746 2.05e-20

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 98.59  E-value: 2.05e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402    2 LLGEEAMMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLH 81
Cdd:TIGR02168  244 LQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEA 323

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   82 DIREQSRKLQEIKE---------QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLM 152
Cdd:TIGR02168  324 QLEELESKLDELAEelaeleeklEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIE 403

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  153 KAKDQGKPEVGEYSKLEKINAEQQ-----LKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGi 227
Cdd:TIGR02168  404 RLEARLERLEDRRERLQQEIEELLkkleeAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAER- 482

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  228 kkKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKIlELEEKHREA-----QVSAQHLEV------- 295
Cdd:TIGR02168  483 --ELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELI-SVDEGYEAAieaalGGRLQAVVVenlnaak 559

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  296 ----HLKQKE----------QHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSL- 360
Cdd:TIGR02168  560 kaiaFLKQNElgrvtflpldSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVVDDLDNALELAk 639

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  361 ----EQRIVEL-----------SEANKLAANSSLFTQRN-------MKAQEEMISELRQQKFYLETQAGKLEAQNRKLEE 418
Cdd:TIGR02168  640 klrpGYRIVTLdgdlvrpggviTGGSAKTNSSILERRREieeleekIEELEEKIAELEKALAELRKELEELEEELEQLRK 719

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  419 QLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKR---QLTELQLSLQERESQLTALQAARAALESQLRQAKTELE 495
Cdd:TIGR02168  720 ELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTEleaEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELK 799

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  496 ETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEdnaelnnqnfylskqldEASGANDEIVQLRSEVD 575
Cdd:TIGR02168  800 ALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEE-----------------QIEELSEDIESLAAEIE 862

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  576 HLRREITEREMQLTSQKQAQLSAPdlqtmEALKTTCTMLEEQVLDLEALNDELLEKERQWEAwrsvLGDEKSQFECRVRE 655
Cdd:TIGR02168  863 ELEELIEELESELEALLNERASLE-----EALALLRSELEELSEELRELESKRSELRRELEE----LREKLAQLELRLEG 933

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  656 LQRMLDtEKQSRARADQRITEsrQVVELAVKEHKAEILALQQALK--EQKLKA------------ESLSDKLNDLEKKHA 721
Cdd:TIGR02168  934 LEVRID-NLQERLSEEYSLTL--EEAEALENKIEDDEEEARRRLKrlENKIKElgpvnlaaieeyEELKERYDFLTAQKE 1010

                          810       820
                   ....*....|....*....|....*.
gi 1039770402  722 MLEMNARSLQQKL-ETERELKQRLLE 746
Cdd:TIGR02168 1011 DLTEAKETLEEAIeEIDREARERFKD 1036
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 22-890 9.08e-20

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 96.58  E-value: 9.08e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   22 EVEAVLSQKEVElkasetqRSLLEQDLATYItecssLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQ 101
Cdd:pfam02463  143 KIEIIAMMKPER-------RLEIEEEAAGSR-----LKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKAL 210

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  102 VEEMRLMMNQLEEDLVSARRRSDLYESELRES----RLAAEEFKRKANECQHKLMKAKDQGKPEVGEYSKLEKINAEQQL 177
Cdd:pfam02463  211 EYYQLKEKLELEEEYLLYLDYLKLNEERIDLLqellRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKL 290

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  178 KIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENR 257
Cdd:pfam02463  291 LAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQ 370

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  258 LKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAH 337
Cdd:pfam02463  371 LEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEK 450

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  338 EKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELrqqkfyletqAGKLEAQNRKLE 417
Cdd:pfam02463  451 EELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSG----------LKVLLALIKDGV 520

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  418 EQLEKISHQDHSDKSRLLELETRLREVSLehEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEET 497
Cdd:pfam02463  521 GGRIISAHGRLGDLGVAVENYKVAISTAV--IVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLE 598

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  498 TAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHL 577
Cdd:pfam02463  599 IDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEI 678

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  578 RREITEREMQLtsQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQ 657
Cdd:pfam02463  679 QELQEKAESEL--AKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSR 756

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  658 RMLDTEKQSRARADQRITEsrqvvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETE 737
Cdd:pfam02463  757 LKKEEKEEEKSELSLKEKE-------LAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEK 829

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  738 RELKQRLLEEQAKLQQQMDLQKNhifrlTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDF 817
Cdd:pfam02463  830 IKEEELEELALELKEEQKLEKLA-----EEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEE 904

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039770402  818 LQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKA 890
Cdd:pfam02463  905 ESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNL 977
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 9-581 5.33e-19

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 93.85  E-value: 5.33e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402    9 MEQEMTRLHRRVSEVEAVLS----QKEV-----ELKASETQRSL---------LEQDLATYITECSSLKRSLEQARMEVS 70
Cdd:COG1196    184 TEENLERLEDILGELERQLEplerQAEKaeryrELKEELKELEAellllklreLEAELEELEAELEELEAELEELEAELA 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   71 QEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLmmnqlEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHK 150
Cdd:COG1196    264 ELEAELEELRLELEELELELEEAQAEEYELLAELARL-----EQDIARLEERRRELEERLEELEEELAELEEELEELEEE 338

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  151 LMKAKDQgkpevgeyskLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKK 230
Cdd:COG1196    339 LEELEEE----------LEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEA 408

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  231 LVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQqmadkilELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKV 310
Cdd:COG1196    409 EEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAA-------EEEAELEEEEEALLELLAELLEEAALLEAALAE 481

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  311 LDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEE 390
Cdd:COG1196    482 LLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAA 561

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  391 MISELRQQK-----FYLETQAGKLEAQNRKLEEQLEK-----------------------------ISHQDHSDKSRLLE 436
Cdd:COG1196    562 AIEYLKAAKagratFLPLDKIRARAALAAALARGAIGaavdlvasdlreadaryyvlgdtllgrtlVAARLEAALRRAVT 641

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  437 LETRLREVSLEHEEQkleLKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQ 516
Cdd:COG1196    642 LAGRLREVTLEGEGG---SAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLE 718

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039770402  517 RKFDALRNSCTVITDLEEQLNQLTEDNAElnnqnfyLSKQLDEASGANDEIVQLRSEVDHLRREI 581
Cdd:COG1196    719 EELEEEALEEQLEAEREELLEELLEEEEL-------LEEEALEELPEPPDLEELERELERLEREI 776
PTZ00121 PTZ00121
MAEBL; Provisional
 12-787 7.51e-19

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 94.05  E-value: 7.51e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   12 EMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQdlatyitecsslKRSLEQARMEVSQEDDKALQLLHDIR--EQSRK 89
Cdd:PTZ00121  1068 QDEGLKPSYKDFDFDAKEDNRADEATEEAFGKAEE------------AKKTETGKAEEARKAEEAKKKAEDARkaEEARK 1135

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   90 LQEIKEQEYQAQVEEMRlmmnqleeDLVSARRRSDLYESElrESRLAAE----EFKRKANECQ--HKLMKAKDQGKPEvg 163
Cdd:PTZ00121  1136 AEDARKAEEARKAEDAK--------RVEIARKAEDARKAE--EARKAEDakkaEAARKAEEVRkaEELRKAEDARKAE-- 1203

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  164 EYSKLEKINAEQQLKIQELQEKLEkAVKASTEATELLQNIRQA-KERAERELEKLHNREDSSEGIKKKLVEAEERRHSLE 242
Cdd:PTZ00121  1204 AARKAEEERKAEEARKAEDAKKAE-AVKKAEEAKKDAEEAKKAeEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADE 1282

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  243 nkVKRLETMERRENRLKDDIQTKSEQIQQMAD---KILELEEKHREAQVSAQHLEVHLKQKEQHYEEKiKVLDNQIKKDL 319
Cdd:PTZ00121  1283 --LKKAEEKKKADEAKKAEEKKKADEAKKKAEeakKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAA-KAEAEAAADEA 1359

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  320 ADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQK 399
Cdd:PTZ00121  1360 EAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKK 1439

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  400 FYLETQAGKLEA---QNRKLEEQLEKISHQDHSDKSRLLELETRLREvslEHEEQKLELKRQLTELQLSLQERESQLTAL 476
Cdd:PTZ00121  1440 AEEAKKADEAKKkaeEAKKAEEAKKKAEEAKKADEAKKKAEEAKKAD---EAKKKAEEAKKKADEAKKAAEAKKKADEAK 1516

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  477 QAARAALESQLRQAKTELeettaeaeeeiQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQ 556
Cdd:PTZ00121  1517 KAEEAKKADEAKKAEEAK-----------KADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEE 1585

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  557 LDEASGANDEIVQLRSEvdhlrREITEREMQLTSQKQAQLSAPDLQTMEALKTTCTMLEEQVLDlEALNDELLEKERQWE 636
Cdd:PTZ00121  1586 AKKAEEARIEEVMKLYE-----EEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAE-EKKKAEELKKAEEEN 1659

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  637 AWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQ---KLKAESLSDKL 713
Cdd:PTZ00121  1660 KIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEeenKIKAEEAKKEA 1739

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  714 NDLEKK---------------HAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADL 778
Cdd:PTZ00121  1740 EEDKKKaeeakkdeeekkkiaHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNL 1819


                   ....*....
gi 1039770402  779 LKTERSDLE 787
Cdd:PTZ00121  1820 VINDSKEME 1828
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 79-718 3.15e-18

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 91.54  E-value: 3.15e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   79 LLHDIREQSRKLQEIKEQ--EYQAQVEEMRlmmnqleedlvsaRRRSDLYESELRESRLAAEEFKRKANECQhklmkakd 156
Cdd:COG1196    194 ILGELERQLEPLERQAEKaeRYRELKEELK-------------ELEAELLLLKLRELEAELEELEAELEELE-------- 252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  157 qgkpevgeySKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEE 236
Cdd:COG1196    253 ---------AELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEE 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  237 RRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIK 316
Cdd:COG1196    324 ELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLE 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  317 KDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELR 396
Cdd:COG1196    404 ELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELL 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  397 QQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLE------LKRQLTELQLSLQERE 470
Cdd:COG1196    484 EELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEaalaaaLQNIVVEDDEVAAAAI 563

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  471 SQLTALQAARAA---LESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELN 547
Cdd:COG1196    564 EYLKAAKAGRATflpLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLA 643

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  548 NQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSApdlqtmealkttctmLEEQVLDLEALNDE 627
Cdd:COG1196    644 GRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELE---------------LEEALLAEEEEERE 708

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  628 LLEKERQWEAWRSVLGDEKSQFE-CRVRELQRMLDTEKQSRARADQRITE--SRQVVELAVKEHKAEI--------LALQ 696
Cdd:COG1196    709 LAEAEEERLEEELEEEALEEQLEaEREELLEELLEEEELLEEEALEELPEppDLEELERELERLEREIealgpvnlLAIE 788

                          650       660
                   ....*....|....*....|..
gi 1039770402  697 QaLKEQKLKAESLSDKLNDLEK 718
Cdd:COG1196    789 E-YEELEERYDFLSEQREDLEE 809
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 10-753 9.41e-18

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 90.03  E-value: 9.41e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   10 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDI--REQS 87
Cdd:pfam02463  264 EEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIeeLEKE 343

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   88 RKLQEIKEQEYQAQVEEMRLMM----NQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKAKDQGKPEVG 163
Cdd:pfam02463  344 LKELEIKREAEEEEEEELEKLQekleQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKE 423

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  164 EYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLEN 243
Cdd:pfam02463  424 EKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKES 503

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  244 KVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKH-----REAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKd 318
Cdd:pfam02463  504 KARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVaistaVIVEVSATADEVEERQKLVRALTELPLGARKLRL- 582

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  319 LADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQ 398
Cdd:pfam02463  583 LIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKS 662

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  399 KFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQA 478
Cdd:pfam02463  663 EVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLK 742

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  479 ARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLD 558
Cdd:pfam02463  743 QKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQL 822

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  559 EASGANDEIVQLRSEvdhlrreitEREMQLTSQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAW 638
Cdd:pfam02463  823 LIEQEEKIKEEELEE---------LALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEE 893

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  639 RSVLGDEKSQFECRVRELQRMLDTEKQSR-ARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLE 717
Cdd:pfam02463  894 KEKEEKKELEEESQKLNLLEEKENEIEERiKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELG 973

                          730       740       750
                   ....*....|....*....|....*....|....*.
gi 1039770402  718 KKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQ 753
Cdd:pfam02463  974 KVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIR 1009
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 200-742 5.74e-17

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 87.00  E-value: 5.74e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  200 LQNIRQAKERAERELEK--------LHNREDSSEGIKKKLVEAEERRHSLENKVKRLETmerRENRLKDDIQTKSEQIQQ 271
Cdd:TIGR04523   24 YKNIANKQDTEEKQLEKklktikneLKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQ---QIKDLNDKLKKNKDKINK 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  272 M-AD-KILELEEKHREAQVSAQHLEV-HLKQKEQHYEEKIKVLDNQIKKDLAD--------------KESLENMMQRHEE 334
Cdd:TIGR04523  101 LnSDlSKINSEIKNDKEQKNKLEVELnKLEKQKKENKKNIDKFLTEIKKKEKEleklnnkyndlkkqKEELENELNLLEK 180

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  335 EAHEKGKILSEQKAMINAMD---SKIRSLEQRIVEL-SEANKL-AANSSLFTQRNMKAQEemISELRQQKFYLETQAGKL 409
Cdd:TIGR04523  181 EKLNIQKNIDKIKNKLLKLElllSNLKKKIQKNKSLeSQISELkKQNNQLKDNIEKKQQE--INEKTTEISNTQTQLNQL 258

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  410 EAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLE------------HEEQKLELK---RQLTELQLSLQERESQLT 474
Cdd:TIGR04523  259 KDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEisdlnnqkeqdwNKELKSELKnqeKKLEEIQNQISQNNKIIS 338

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  475 ALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQ--NFY 552
Cdd:TIGR04523  339 QLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQikKLQ 418

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  553 LSKQLDEASGAN--DEIVQLRSEVDHLRREITEREM------QLTSQKQAQLSA--------------------PDLQTM 604
Cdd:TIGR04523  419 QEKELLEKEIERlkETIIKNNSEIKDLTNQDSVKELiiknldNTRESLETQLKVlsrsinkikqnleqkqkelkSKEKEL 498

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  605 EALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTE--KQSRARADQRITESRQV-- 680
Cdd:TIGR04523  499 KKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDDFELKKEnlEKEIDEKNKEIEELKQTqk 578

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039770402  681 --------VELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLET-ERELKQ 742
Cdd:TIGR04523  579 slkkkqeeKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKlKQEVKQ 649
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
83-633 5.77e-17

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 87.04  E-value: 5.77e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   83 IREQSRKLQEIKEqeYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRkanecqhklmkakdqgkpev 162
Cdd:PRK03918   171 IKEIKRRIERLEK--FIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEK-------------------- 228

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  163 gEYSKLEKINAEqqlkIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLE 242
Cdd:PRK03918   229 -EVKELEELKEE----IEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEYIKLSEFYE 303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  243 NKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVhLKQKEQHYEEKIKVLDN--QIKKDLA 320
Cdd:PRK03918   304 EYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEE-LEERHELYEEAKAKKEEleRLKKRLT 382

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  321 DK--ESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEA-NKLAANSSLFTQRN----MKAQEEMIS 393
Cdd:PRK03918   383 GLtpEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAkGKCPVCGRELTEEHrkelLEEYTAELK 462

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  394 ELRQQKFYLETQAGKLEAQNRKLEEQLEKISH--QDHSDKSRLLELETRLREVSLEHEEQKLE----LKRQLTEL---QL 464
Cdd:PRK03918   463 RIEKELKEIEEKERKLRKELRELEKVLKKESEliKLKELAEQLKELEEKLKKYNLEELEKKAEeyekLKEKLIKLkgeIK 542

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  465 SLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEE-----------IQALtahrDEIQRKFDALRNSCTVITDLE 533
Cdd:PRK03918   543 SLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELgfesveeleerLKEL----EPFYNEYLELKDAEKELEREE 618

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  534 EQLNQLTEDnaelnnqnfyLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTCTM 613
Cdd:PRK03918   619 KELKKLEEE----------LDKAFEELAETEKRLEELRKELEELEKKYSEEEYEELREEYLELSRELAGLRAELEELEKR 688

                          570       580
                   ....*....|....*....|
gi 1039770402  614 LEEQVLDLEALNDELLEKER 633
Cdd:PRK03918   689 REEIKKTLEKLKEELEEREK 708
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 236-887 1.24e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 86.26  E-value: 1.24e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  236 ERRHSLENKvkrLETMERRENRLKDDI-----QTKSEQIQ-QMADKILELEEKHREAQ--VSAQHLEVHLKQKEQ----- 302
Cdd:TIGR02168  172 ERRKETERK---LERTRENLDRLEDILnelerQLKSLERQaEKAERYKELKAELRELElaLLVLRLEELREELEElqeel 248

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  303 -HYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELseanklaansslft 381
Cdd:TIGR02168  249 kEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANL-------------- 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  382 QRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQK---LELKRQ 458
Cdd:TIGR02168  315 ERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRskvAQLELQ 394

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  459 LTELQLSLQERESQLTALQAARAALESQLRQ--------AKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvIT 530
Cdd:TIGR02168  395 IASLNNEIERLEARLERLEDRRERLQQEIEEllkkleeaELKELQAELEELEEELEELQEELERLEEALEELREE---LE 471

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  531 DLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQL---RSEVDHLRREITER-------------------EMQL 588
Cdd:TIGR02168  472 EAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALlknQSGLSGILGVLSELisvdegyeaaieaalggrlQAVV 551

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  589 TSQKQAQLSAPDLQTmEALKTTCTMLEEQVL---DLEALNDELLEKERQWEAWRSVLGDEKSQFE---------CRV--- 653
Cdd:TIGR02168  552 VENLNAAKKAIAFLK-QNELGRVTFLPLDSIkgtEIQGNDREILKNIEGFLGVAKDLVKFDPKLRkalsyllggVLVvdd 630

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  654 ----RELQRMLD------TEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAML 723
Cdd:TIGR02168  631 ldnaLELAKKLRpgyrivTLDGDLVRPGGVITGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEEL 710

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  724 EMNARSLQQKLET-------ERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVL 796
Cdd:TIGR02168  711 EEELEQLRKELEElsrqisaLRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQ 790

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  797 YSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVplqyNELKLALEKEKARCAELEEALQKTRI 876
Cdd:TIGR02168  791 IEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRL----EDLEEQIEELSEDIESLAAEIEELEE 866

                          730
                   ....*....|.
gi 1039770402  877 ELRSAREEAAH 887
Cdd:TIGR02168  867 LIEELESELEA 877
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
19-585 1.56e-16

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 85.89  E-value: 1.56e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   19 RVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEqaRMEVSQEDDKALQLLHDIREQSRKLQEIKEQEY 98
Cdd:PRK03918   187 RTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVK--ELEELKEEIEELEKELESLEGSKRKLEEKIREL 264

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   99 QAQVEEMRLMMNQLEEdlvSARRRSDLYESELRESRLaaEEFKRKANECQHKLMKakdqgkpevgEYSKLEKINAEQQLK 178
Cdd:PRK03918   265 EERIEELKKEIEELEE---KVKELKELKEKAEEYIKL--SEFYEEYLDELREIEK----------RLSRLEEEINGIEER 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  179 IQELQEKLEKAVKASTEATELLQNIRQAKERAErELEKLHNREDSSEGIKKKL--VEAEERRHSLENKVKRLETMERREN 256
Cdd:PRK03918   330 IKELEEKEERLEELKKKLKELEKRLEELEERHE-LYEEAKAKKEELERLKKRLtgLTPEKLEKELEELEKAKEEIEEEIS 408

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  257 RLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEvhlkqkEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEA 336
Cdd:PRK03918   409 KITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELT------EEHRKELLEEYTAELKRIEKELKEIEEKERKLRKEL 482

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  337 HEKGKILSEQKAMI--NAMDSKIRSLEQRIVELsEANKLAANSSLFTqrnmKAQEEMIsELRQQKFYLETQAGKLEAQNR 414
Cdd:PRK03918   483 RELEKVLKKESELIklKELAEQLKELEEKLKKY-NLEELEKKAEEYE----KLKEKLI-KLKGEIKSLKKELEKLEELKK 556

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  415 KLEEQLEKIshqdHSDKSRLLELETRLREVSLEHEEqklELKRQLTELQ------LSLQERESQLTALQAARAALESQLR 488
Cdd:PRK03918   557 KLAELEKKL----DELEEELAELLKELEELGFESVE---ELEERLKELEpfyneyLELKDAEKELEREEKELKKLEEELD 629

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  489 QAktelEETTAEAEEEIQALTAHRDEIQRKFDalrnsctvitdlEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIv 568
Cdd:PRK03918   630 KA----FEELAETEKRLEELRKELEELEKKYS------------EEEYEELREEYLELSRELAGLRAELEELEKRREEI- 692

                          570
                   ....*....|....*..
gi 1039770402  569 qlRSEVDHLRREITERE 585
Cdd:PRK03918   693 --KKTLEKLKEELEERE 707
PTZ00121 PTZ00121
MAEBL; Provisional
 10-489 1.61e-16

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 86.35  E-value: 1.61e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   10 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARM-----EVSQEDDKALQLLHDIR 84
Cdd:PTZ00121  1259 EARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKadeakKKAEEAKKKADAAKKKA 1338

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   85 EQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLV---SARRRSDLYESELRESRLA------AEEFKRKANECQHKLMKAK 155
Cdd:PTZ00121  1339 EEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKkkeEAKKKADAAKKKAEEKKKAdeakkkAEEDKKKADELKKAAAAKK 1418

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  156 --DQGKPEVGEYSKLE--KINAEQQLKIQELQEKLEKAVKA----------------------STEATELLQNIRQAKER 209
Cdd:PTZ00121  1419 kaDEAKKKAEEKKKADeaKKKAEEAKKADEAKKKAEEAKKAeeakkkaeeakkadeakkkaeeAKKADEAKKKAEEAKKK 1498

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  210 AErELEKLHNREDSSEGIKK--------KLVEAEERRHSLENK----------VKRLETMERRENRLKDDIQTKSEQIQQ 271
Cdd:PTZ00121  1499 AD-EAKKAAEAKKKADEAKKaeeakkadEAKKAEEAKKADEAKkaeekkkadeLKKAEELKKAEEKKKAEEAKKAEEDKN 1577

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  272 MADKILE----LEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQK 347
Cdd:PTZ00121  1578 MALRKAEeakkAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEE 1657

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  348 aminamDSKIRSLEQRIVElsEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLEtQAGKLEAQNRKLEEQLEKishQD 427
Cdd:PTZ00121  1658 ------ENKIKAAEEAKKA--EEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAE-ELKKKEAEEKKKAEELKK---AE 1725

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039770402  428 HSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQ 489
Cdd:PTZ00121  1726 EENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDE 1787
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 33-741 3.93e-16

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 84.73  E-value: 3.93e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   33 ELKASETQRSLLEQDLAtyitecsSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEY-------------- 98
Cdd:TIGR02169  231 EKEALERQKEAIERQLA-------SLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQlrvkekigeleaei 303

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   99 ---QAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKAKDQGKPEVGEYSKLEKINAEQ 175
Cdd:TIGR02169  304 aslERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAET 383

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  176 QLKIQELQEKLEKAVKastEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRhslENKVKRLETMERRE 255
Cdd:TIGR02169  384 RDELKDYREKLEKLKR---EINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEK---EDKALEIKKQEWKL 457

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  256 NRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQ---HYEEKIKVLDNQIKK--------------- 317
Cdd:TIGR02169  458 EQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEErvrGGRAVEEVLKASIQGvhgtvaqlgsvgery 537

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  318 ----DLADKESLENMMQRHEEEAHEKGKILSEQKAM------INAMDSKIRSLE--------QRIVELSEANKLAANSSL 379
Cdd:TIGR02169  538 ataiEVAAGNRLNNVVVEDDAVAKEAIELLKRRKAGratflpLNKMRDERRDLSilsedgviGFAVDLVEFDPKYEPAFK 617

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  380 FTQRNMKAQEEMISELRQQ-KFYLETQAGKLeaqnrkleeqLEKI-SHQDHSDKSRLLELETR-LREVSLEHEEQKLELK 456
Cdd:TIGR02169  618 YVFGDTLVVEDIEAARRLMgKYRMVTLEGEL----------FEKSgAMTGGSRAPRGGILFSRsEPAELQRLRERLEGLK 687

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  457 RQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQL 536
Cdd:TIGR02169  688 RELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARI 767

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  537 NQLTED----NAELNNQNFYLSKQL-----DEASGANDEIVQLRSEVDHLRREITER--EMQLTSQKQAQLSAPDLQTME 605
Cdd:TIGR02169  768 EELEEDlhklEEALNDLEARLSHSRipeiqAELSKLEEEVSRIEARLREIEQKLNRLtlEKEYLEKEIQELQEQRIDLKE 847

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  606 ALKTTCTMLEEQVLDLEALNDELLEKE---RQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRI---TESRQ 679
Cdd:TIGR02169  848 QIKSIEKEIENLNGKKEELEEELEELEaalRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLselKAKLE 927

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  680 VVELAVKEH--------------------KAEILALQ---QALKEQKLKA----ESLSDKLNDLEKKHAMLEMNARSLQQ 732
Cdd:TIGR02169  928 ALEEELSEIedpkgedeeipeeelsledvQAELQRVEeeiRALEPVNMLAiqeyEEVLKRLDELKEKRAKLEEERKAILE 1007


                   ....*....
gi 1039770402  733 KLETERELK 741
Cdd:TIGR02169 1008 RIEEYEKKK 1016
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 135-787 1.05e-15

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 83.09  E-value: 1.05e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  135 LAAEEFKrkanecQHKLMKAKDQGKPEvgEYSKLEKINAEQQLKIQELQEKLEKAVKastEATELLQNIRQAKERAEREL 214
Cdd:TIGR00618  181 LALMEFA------KKKSLHGKAELLTL--RSQLLTLCTPCMPDTYHERKQVLEKELK---HLREALQQTQQSHAYLTQKR 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  215 EKLHNREDSSEGIKKKLVEAEErrhsLENKVKRLETMERRENRlkddiQTKSEQIQQMADKILELEEKHREAQVSAQHLE 294
Cdd:TIGR00618  250 EAQEEQLKKQQLLKQLRARIEE----LRAQEAVLEETQERINR-----ARKAAPLAAHIKAVTQIEQQAQRIHTELQSKM 320

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  295 VHLKQKEQHYEEKIKVldnqiKKDLADKESLENMMQRHEEE---AHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEAN 371
Cdd:TIGR00618  321 RSRAKLLMKRAAHVKQ-----QSSIEEQRRLLQTLHSQEIHirdAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQKL 395

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  372 KLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLRevSLEHEEQ 451
Cdd:TIGR00618  396 QSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQ--SLKEREQ 473

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  452 KLELKRQLTelqlslqERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITD 531
Cdd:TIGR00618  474 QLQTKEQIH-------LQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNPGPLTRRMQRGEQTYAQLETSEED 546

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  532 LEEQLNQLTEDNAELNNQ------NFYLSKQLDEASGANDEIV-QLRSEVDHLRREITEREMQLTSQKQAQLSA--PDLQ 602
Cdd:TIGR00618  547 VYHQLTSERKQRASLKEQmqeiqqSFSILTQCDNRSKEDIPNLqNITVRLQDLTEKLSEAEDMLACEQHALLRKlqPEQD 626

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  603 TMEALKTTCTMLEEQVLDLEALNDELLE--KERQWEAWRSVLGDEKSQFECRVRELQRMldtekQSRARADQRITESRQV 680
Cdd:TIGR00618  627 LQDVRLHLQQCSQELALKLTALHALQLTltQERVREHALSIRVLPKELLASRQLALQKM-----QSEKEQLTYWKEMLAQ 701

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  681 VELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKN 760
Cdd:TIGR00618  702 CQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELS 781

                          650       660
                   ....*....|....*....|....*...
gi 1039770402  761 HIFRLTQGLQEALD-RADLLKTERSDLE 787
Cdd:TIGR00618  782 HLAAEIQFFNRLREeDTHLLKTLEAEIG 809
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 2-756 1.33e-15

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 82.81  E-value: 1.33e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402    2 LLGEEAMMEQEMTRLHRRVSEVEAVLSQKEVELkasetqrslleQDLATyitECSSLKRSLEQARMEVSQE-DDKALQLL 80
Cdd:TIGR02169  228 LLKEKEALERQKEAIERQLASLEEELEKLTEEI-----------SELEK---RLEEIEQLLEELNKKIKDLgEEEQLRVK 293

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   81 HDIREQSRKLQEIkeqeyQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKAKDQGKP 160
Cdd:TIGR02169  294 EKIGELEAEIASL-----ERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELED 368

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  161 EVGEYSKLEKINAEQQLKIQELQEKLEKAVKastEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRhs 240
Cdd:TIGR02169  369 LRAELEEVDKEFAETRDELKDYREKLEKLKR---EINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEK-- 443

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  241 lENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQ---HYEEKIKVLDNQIKK 317
Cdd:TIGR02169  444 -EDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEErvrGGRAVEEVLKASIQG 522

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  318 -------------------DLADKESLENMMQRHEEEAHEKGKILSEQKAM------INAMDSKIRSLE--------QRI 364
Cdd:TIGR02169  523 vhgtvaqlgsvgeryataiEVAAGNRLNNVVVEDDAVAKEAIELLKRRKAGratflpLNKMRDERRDLSilsedgviGFA 602

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  365 VELSEANKLAANSSLFTQRNMKAQEEMISELRQQ-KFYLETQAGKLeaqnrkleeqLEKI-SHQDHSDKSRLLELETR-L 441
Cdd:TIGR02169  603 VDLVEFDPKYEPAFKYVFGDTLVVEDIEAARRLMgKYRMVTLEGEL----------FEKSgAMTGGSRAPRGGILFSRsE 672

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  442 REVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDA 521
Cdd:TIGR02169  673 PAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQE 752

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  522 LRNSCTVITDLEEQLNQLTEDnaelnnqnfylskqldeasgandeIVQLRSEVDHLRREITEREMQltsQKQAQlsapdl 601
Cdd:TIGR02169  753 IENVKSELKELEARIEELEED------------------------LHKLEEALNDLEARLSHSRIP---EIQAE------ 799

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  602 qtMEALKTTCTMLEEQVLDLEA-LNDELLEKErqweawrsvLGDEKSQfecrvRELQRMLDTEKQSRARADQritesrqv 680
Cdd:TIGR02169  800 --LSKLEEEVSRIEARLREIEQkLNRLTLEKE---------YLEKEIQ-----ELQEQRIDLKEQIKSIEKE-------- 855

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  681 velaVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQK---LETERE-LKQRLLEEQAKLQQQMD 756
Cdd:TIGR02169  856 ----IENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKieeLEAQIEkKRKRLSELKAKLEALEE 931
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 235-947 3.76e-15

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 81.32  E-value: 3.76e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  235 EERRHSLENKVKRL----ETMERRENRLKD---DIQTKSEQIQQMADKILELeeKHREAQvSAQHLEVHLkQKEQHYEEK 307
Cdd:pfam15921   81 EEYSHQVKDLQRRLnesnELHEKQKFYLRQsviDLQTKLQEMQMERDAMADI--RRRESQ-SQEDLRNQL-QNTVHELEA 156

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  308 IKVLDNQIKKDLADK-ESLENMMQRHEEEAHE-----------KGKILSEQKAM---------------INAMDSKIRSL 360
Cdd:pfam15921  157 AKCLKEDMLEDSNTQiEQLRKMMLSHEGVLQEirsilvdfeeaSGKKIYEHDSMstmhfrslgsaiskiLRELDTEISYL 236

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  361 EQRIVELSEA-NKLAANSS----LFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKS--- 432
Cdd:pfam15921  237 KGRIFPVEDQlEALKSESQnkieLLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSmym 316

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  433 -RLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAH 511
Cdd:pfam15921  317 rQLSDLESTVSQLRSELREAKRMYEDKIEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLE 396

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  512 RDEIQRKFDALRNSCTVITDLEEQLNQ-----------LTEDNAELNNQnfyLSKQLDEASGANDEI-------VQLRSE 573
Cdd:pfam15921  397 KEQNKRLWDRDTGNSITIDHLRRELDDrnmevqrlealLKAMKSECQGQ---MERQMAAIQGKNESLekvssltAQLEST 473

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  574 VDHLRR---EITEREMQLTS-------------QKQAQLSAPD-------------LQTMEALKTTCTMLEEQVLDLEAL 624
Cdd:pfam15921  474 KEMLRKvveELTAKKMTLESsertvsdltaslqEKERAIEATNaeitklrsrvdlkLQELQHLKNEGDHLRNVQTECEAL 553

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  625 NDELLEKERQWEAWRSVLGD-----------------EKSQFECRVRELQRMLDTEKQSRARADQRITE-SRQVVELAVK 686
Cdd:pfam15921  554 KLQMAEKDKVIEILRQQIENmtqlvgqhgrtagamqvEKAQLEKEINDRRLELQEFKILKDKKDAKIRElEARVSDLELE 633

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  687 EHK-----AEILALQQALKEQKLK----AESLSDKLNDLEKKHAMLEMNARSLQQKLE-TERELKQRLLEEQAKLQQ--- 753
Cdd:pfam15921  634 KVKlvnagSERLRAVKDIKQERDQllneVKTSRNELNSLSEDYEVLKRNFRNKSEEMEtTTNKLKMQLKSAQSELEQtrn 713

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  754 ---QMDLQKNHIFRLTQGLQEALD----RADLLKTERSDLEYQLENI---QVLYSHEKVKMegtiSQQTKLIDFLQAKMD 823
Cdd:pfam15921  714 tlkSMEGSDGHAMKVAMGMQKQITakrgQIDALQSKIQFLEEAMTNAnkeKHFLKEEKNKL----SQELSTVATEKNKMA 789

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  824 QPAKKKKGLFSRRKEDPAlptqvplqynELKLALEKEKARCAELEEALQktRIELRSAREEAAHR---KATDHP-HPSTP 899
Cdd:pfam15921  790 GELEVLRSQERRLKEKVA----------NMEVALDKASLQFAECQDIIQ--RQEQESVRLKLQHTldvKELQGPgYTSNS 857

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*....
gi 1039770402  900 ATARQQIAMSAIVRSPEHQPSAMSLLAPPSSR-RKESSTPEEFSRRLKE 947
Cdd:pfam15921  858 SMKPRLLQPASFTRTHSNVPSSQSTASFLSHHsRKTNALKEDPTRDLKQ 906
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2-492 1.01e-14

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 79.98  E-value: 1.01e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402    2 LLGEEAMMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLH 81
Cdd:COG1196    293 LLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEA 372

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   82 DIREQSRKLQEIKEQEYQAQVEEMRLM--MNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKAKdqgk 159
Cdd:COG1196    373 ELAEAEEELEELAEELLEALRAAAELAaqLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAA---- 448

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  160 pevgeySKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRH 239
Cdd:COG1196    449 ------EEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGL 522

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  240 S-------------------------LENKVKRLETMERRENRLKDDIQTKSEQIQqmADKILELEEKHREAQVSAQHLE 294
Cdd:COG1196    523 AgavavligveaayeaaleaalaaalQNIVVEDDEVAAAAIEYLKAAKAGRATFLP--LDKIRARAALAAALARGAIGAA 600

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  295 VHLKQKEQHYEEKIKVLDNQIKK----DLADKESLENMMQRHEEEAHEK---GKILSEQKAMI----NAMDSKIRSLEQR 363
Cdd:COG1196    601 VDLVASDLREADARYYVLGDTLLgrtlVAARLEAALRRAVTLAGRLREVtleGEGGSAGGSLTggsrRELLAALLEAEAE 680

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  364 IVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDkSRLLELETRLRE 443
Cdd:COG1196    681 LEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEEL-LEEEALEELPEP 759

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039770402  444 VSLEHEEQKLE-LKRQLTEL----QLSLQEresqLTALQAARAALESQ---LRQAKT 492
Cdd:COG1196    760 PDLEELERELErLEREIEALgpvnLLAIEE----YEELEERYDFLSEQredLEEARE 812
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 173-872 1.51e-14

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 79.34  E-value: 1.51e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  173 AEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEgiKKKLVEAEERRHSLENKVKRLETME 252
Cdd:TIGR02169  166 AEFDRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREKAERYQALLK--EKREYEGYELLKEKEALERQKEAIE 243

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  253 RRENRLKDDIQTKSEQIQQMADKILELEEKHRE-------------AQVSAQHLEVH-----LKQKEQHYEEKIKVLDNQ 314
Cdd:TIGR02169  244 RQLASLEEELEKLTEEISELEKRLEEIEQLLEElnkkikdlgeeeqLRVKEKIGELEaeiasLERSIAEKERELEDAEER 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  315 IKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLaansslfTQRNMKAQEEMISE 394
Cdd:TIGR02169  324 LAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAE-------TRDELKDYREKLEK 396

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  395 LRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKR---QLTELQLSLQERES 471
Cdd:TIGR02169  397 LKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQlaaDLSKYEQELYDLKE 476

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  472 QLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALR---------------------NSCTVIT 530
Cdd:TIGR02169  477 EYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAqlgsvgeryataievaagnrlNNVVVED 556

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  531 DL--EEQLNQLTEDNA------ELNN-QNFYLSKQLDEASGANDEIVQL--------------------RSEVDHLRR-- 579
Cdd:TIGR02169  557 DAvaKEAIELLKRRKAgratflPLNKmRDERRDLSILSEDGVIGFAVDLvefdpkyepafkyvfgdtlvVEDIEAARRlm 636

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  580 ----------EITEREMQLTSQKQAQLSAPDLQTmeALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQF 649
Cdd:TIGR02169  637 gkyrmvtlegELFEKSGAMTGGSRAPRGGILFSR--SEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDA 714

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  650 ECRVRELQRMLDTEKQSRARADQRITESR---QVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMn 726
Cdd:TIGR02169  715 SRKIGEIEKEIEQLEQEEEKLKERLEELEedlSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRI- 793

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  727 aRSLQQKLETERELKQRLLEEQAKLQQqmDLQKNHIFR--LTQGLQEALDRADLLKTERSDLEYQLENIQVlyshEKVKM 804
Cdd:TIGR02169  794 -PEIQAELSKLEEEVSRIEARLREIEQ--KLNRLTLEKeyLEKEIQELQEQRIDLKEQIKSIEKEIENLNG----KKEEL 866

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770402  805 EGTISQqtklidfLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQ 872
Cdd:TIGR02169  867 EEELEE-------LEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLE 927
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
204-805 3.22e-14

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 78.18  E-value: 3.22e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  204 RQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKH 283
Cdd:PRK03918   144 DESREKVVRQILGLDDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREEL 223

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  284 REAQVSAQHLEVHlkqkeqhyEEKIKVLDNQIKKDLADKESLENMMQRHEEeahekgkilseqkaMINAMDSKIRSLEQR 363
Cdd:PRK03918   224 EKLEKEVKELEEL--------KEEIEELEKELESLEGSKRKLEEKIRELEE--------------RIEELKKEIEELEEK 281

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  364 IVELSEANKLAansslftqRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIShqdhSDKSRLLELETRLRE 443
Cdd:PRK03918   282 VKELKELKEKA--------EEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELE----EKEERLEELKKKLKE 349

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  444 V-----SLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALEsqLRQAKTELEETTAEAEEEIQALTAHRDEIQRK 518
Cdd:PRK03918   350 LekrleELEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKELEE--LEKAKEEIEEEISKITARIGELKKEIKELKKA 427

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  519 FDALRNS------CTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREM--QLTS 590
Cdd:PRK03918   428 IEELKKAkgkcpvCGRELTEEHRKELLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKLKELaeQLKE 507

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  591 QKQaQLSAPDLQTMEALKTTCTMLEEQVLDLEA----LNDELLEKErqweawrsvlgdeksQFECRVRELQRMLDTEKQS 666
Cdd:PRK03918   508 LEE-KLKKYNLEELEKKAEEYEKLKEKLIKLKGeiksLKKELEKLE---------------ELKKKLAELEKKLDELEEE 571

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  667 RARADQRITE----SRQVVELAVKEHKA---EILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERE 739
Cdd:PRK03918   572 LAELLKELEElgfeSVEELEERLKELEPfynEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEE 651

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039770402  740 LKQRLLEEQ-AKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIqvlyshEKVKME 805
Cdd:PRK03918   652 LEKKYSEEEyEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEER------EKAKKE 712
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
5-485 1.55e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 75.87  E-value: 1.55e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402    5 EEAMMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQdLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIR 84
Cdd:PRK03918   246 ELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKE-LKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEIN 324

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   85 EQSRKLQEIKEQEyqAQVEEMRLMMNQLEEDLvsarrrsdlyeSELRESRLAAEEFKRKANECQhKLMKAKDQGKPE--V 162
Cdd:PRK03918   325 GIEERIKELEEKE--ERLEELKKKLKELEKRL-----------EELEERHELYEEAKAKKEELE-RLKKRLTGLTPEklE 390

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  163 GEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAE---RELEKLHNREDSSE------GIKKKLVE 233
Cdd:PRK03918   391 KELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPvcgRELTEEHRKELLEEytaelkRIEKELKE 470

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  234 AEERRHSLENKVKRLETMERRENRLKddiqtkseQIQQMADKILELEEKHREaqVSAQHLEVHLKQKEQHYEEKIKVLDN 313
Cdd:PRK03918   471 IEEKERKLRKELRELEKVLKKESELI--------KLKELAEQLKELEEKLKK--YNLEELEKKAEEYEKLKEKLIKLKGE 540

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  314 Q--IKKDLADKESLENMMQRHEEEAHEKGKILSE-QKAMINAMDSKIRSLEQRIVELSEANK---LAANSSLFTQRNMKA 387
Cdd:PRK03918   541 IksLKKELEKLEELKKKLAELEKKLDELEEELAElLKELEELGFESVEELEERLKELEPFYNeylELKDAEKELEREEKE 620

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  388 QEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKS-RLLELETRLREVslehEEQKLELKRQLTELQLSL 466
Cdd:PRK03918   621 LKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSEEEYEELReEYLELSRELAGL----RAELEELEKRREEIKKTL 696

                          490
                   ....*....|....*....
gi 1039770402  467 QERESQLTALQAARAALES 485
Cdd:PRK03918   697 EKLKEELEEREKAKKELEK 715
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
10-573 2.69e-13

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 75.08  E-value: 2.69e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   10 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLatyiTECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRK 89
Cdd:PRK02224   198 EKEEKDLHERLNGLESELAELDEEIERYEEQREQARETR----DEADEVLEEHEERREELETLEAEIEDLRETIAETERE 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   90 LQEIKEQeyqaqVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMkakdqgkpevgeyskle 169
Cdd:PRK02224   274 REELAEE-----VRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLE----------------- 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  170 kinaEQQLKIQElqeklekavkASTEATELLQNIRQAKERAERELEKlhnREDSSEGIKKKLVEAEERRHSLENKVKRLE 249
Cdd:PRK02224   332 ----ECRVAAQA----------HNEEAESLREDADDLEERAEELREE---AAELESELEEAREAVEDRREEIEELEEEIE 394

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  250 TMERRENRLkddiqtkSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLD-------NQIKKDLADK 322
Cdd:PRK02224   395 ELRERFGDA-------PVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEagkcpecGQPVEGSPHV 467

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  323 ESLENMMQRHEEEAHEkgkiLSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQR------NMKAQEEMISELR 396
Cdd:PRK02224   468 ETIEEDRERVEELEAE----LEDLEEEVEEVEERLERAEDLVEAEDRIERLEERREDLEELiaerreTIEEKRERAEELR 543

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  397 QQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVS--------LEHEEQKLE-LKRQLTELQLSLQ 467
Cdd:PRK02224   544 ERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLErirtllaaIADAEDEIErLREKREALAELND 623

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  468 ERESQLTALQAARAALES--------QLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCtvitdleEQLNQL 539
Cdd:PRK02224   624 ERRERLAEKRERKRELEAefdearieEAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENEL-------EELEEL 696

                          570       580       590
                   ....*....|....*....|....*....|....
gi 1039770402  540 TEDNAELNNQNFYLSKQLDEASGANDEIVQLRSE 573
Cdd:PRK02224   697 RERREALENRVEALEALYDEAEELESMYGDLRAE 730
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
65-660 3.50e-13

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 74.69  E-value: 3.50e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   65 ARMEVSQEDDKALQLLHDIREQsrkLQEIKEQEYQAQVEEMRLMMNQLEEDLvsarrrsdlyeSELRESRLAAEEFKRKA 144
Cdd:PRK02224   174 ARLGVERVLSDQRGSLDQLKAQ---IEEKEEKDLHERLNGLESELAELDEEI-----------ERYEEQREQARETRDEA 239

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  145 NEcqhklMKAKDQGKPEvgeysKLEKINAEqqlkIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSS 224
Cdd:PRK02224   240 DE-----VLEEHEERRE-----ELETLEAE----IEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLD 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  225 EGIKKKLveaEERRHSLEnkvKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKE--- 301
Cdd:PRK02224   306 DADAEAV---EARREELE---DRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAReav 379

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  302 QHYEEKIKVLDNQI---KKDLAD-KESLENMMQRHEEEAHEKgkilSEQKAMINAMDSKIRSLEQRIVELSEAnkLAANS 377
Cdd:PRK02224   380 EDRREEIEELEEEIeelRERFGDaPVDLGNAEDFLEELREER----DELREREAELEATLRTARERVEEAEAL--LEAGK 453

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  378 SLFTQRNMKAQE--EMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIShqdhsdksRLLELETRLREVslehEEQKLEL 455
Cdd:PRK02224   454 CPECGQPVEGSPhvETIEEDRERVEELEAELEDLEEEVEEVEERLERAE--------DLVEAEDRIERL----EERREDL 521

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  456 KRQLTELQLSLQERESQLTALQAARAALES---QLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTV---I 529
Cdd:PRK02224   522 EELIAERRETIEEKRERAEELRERAAELEAeaeEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLERIRTLlaaI 601

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  530 TDLEEQLNQLTEDNAELNNQNFYLSKQLDEASganDEIVQLRSEVDHLRRE---------------ITEREMQLTSQKQA 594
Cdd:PRK02224   602 ADAEDEIERLREKREALAELNDERRERLAEKR---ERKRELEAEFDEARIEearedkeraeeyleqVEEKLDELREERDD 678

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039770402  595 QLSA-----PDLQTMEALKTTCTMLEEQVLDLEALNDELlekerqwEAWRSVLGDEKSQFECR-VRELQRML 660
Cdd:PRK02224   679 LQAEigaveNELEELEELRERREALENRVEALEALYDEA-------EELESMYGDLRAELRQRnVETLERML 743
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 13-769 6.04e-13

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 74.23  E-value: 6.04e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   13 MTRLHRRVSEVEAVLSQKEVELkasETQrsLLEQDLATYITECSSLKRSLEQARMEVSQE---DDKALQLLHDIREQSRK 89
Cdd:TIGR00618  184 MEFAKKKSLHGKAELLTLRSQL---LTL--CTPCMPDTYHERKQVLEKELKHLREALQQTqqsHAYLTQKREAQEEQLKK 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   90 LQEIKEQeyQAQVEEMRLMMNQLEEdLVSARRRSDLYESELRESRlAAEEFKRKANECQHKLMKAKDQGKPEVGEYSKLE 169
Cdd:TIGR00618  259 QQLLKQL--RARIEELRAQEAVLEE-TQERINRARKAAPLAAHIK-AVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHV 334

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  170 KINAEQQLKIQELQEkLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLE 249
Cdd:TIGR00618  335 KQQSSIEEQRRLLQT-LHSQEIHIRDAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATID 413

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  250 TMERRENRLKDDIQTKSEQiQQMADKILELEEKHREAQVSAQHLE-VHLKQKEQHYEEKIKVLDNqikkdladkesLENM 328
Cdd:TIGR00618  414 TRTSAFRDLQGQLAHAKKQ-QELQQRYAELCAAAITCTAQCEKLEkIHLQESAQSLKEREQQLQT-----------KEQI 481

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  329 MQRHEEEAHEKGKILSEQKaminamdSKIRSLEQRIVELSEANKLAANSSLFTQRnmkaqeemISELRQQKFYLETQAGK 408
Cdd:TIGR00618  482 HLQETRKKAVVLARLLELQ-------EEPCPLCGSCIHPNPARQDIDNPGPLTRR--------MQRGEQTYAQLETSEED 546

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  409 LEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLR 488
Cdd:TIGR00618  547 VYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQD 626

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  489 QAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQL---NQLTEDNAE-LNNQNFYLSKQLDEASGAN 564
Cdd:TIGR00618  627 LQDVRLHLQQCSQELALKLTALHALQLTLTQERVREHALSIRVLPKELlasRQLALQKMQsEKEQLTYWKEMLAQCQTLL 706

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  565 DEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERqweawrsvLGD 644
Cdd:TIGR00618  707 RELETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQ--------TGA 778

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  645 EKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKehkAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLE 724
Cdd:TIGR00618  779 ELSHLAAEIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILN---LQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYE 855

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*
gi 1039770402  725 MNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGL 769
Cdd:TIGR00618  856 ECSKQLAQLTQEQAKIIQLSDKLNGINQIKIQFDGDALIKFLHEI 900
C1_MgcRacGAP cd20821
protein kinase C conserved region 1 (C1 domain) found in male germ cell RacGap (MgcRacGAP) and ...
 953-1007 1.94e-12

protein kinase C conserved region 1 (C1 domain) found in male germ cell RacGap (MgcRacGAP) and similar proteins; MgcRacGAP, also called Rac GTPase-activating protein 1 (RACGAP1) or protein CYK4, plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling; and ii) after phosphorylation by aurora B, MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain an N-terminal C1 domain, and a C-terminal RhoGAP domain. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410371  Cd Length: 55  Bit Score: 63.19  E-value: 1.94e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1039770402  953 IPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLPA 1007
Cdd:cd20821      1 RPHRFVSKTVIKPETCVVCGKRIKFGKKALKCKDCRVVCHPDCKDKLPLPCVPTS 55
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 33-590 1.97e-12

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 72.36  E-value: 1.97e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   33 ELKASETQRSLLEqdlatyiTECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQeyqaqVEEMRLMMNQL 112
Cdd:TIGR04523  111 EIKNDKEQKNKLE-------VELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQ-----KEELENELNLL 178

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  113 EEDLVSARRRSDLYESELRESRL---AAEEFKRKANECQHKLMKAKDQgkpevgeYSKLEKINAEQQLKIQELQEKLEKA 189
Cdd:TIGR04523  179 EKEKLNIQKNIDKIKNKLLKLELllsNLKKKIQKNKSLESQISELKKQ-------NNQLKDNIEKKQQEINEKTTEISNT 251

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  190 VkasteatellQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRE--NRLKDDIQTKSE 267
Cdd:TIGR04523  252 Q----------TQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQDwnKELKSELKNQEK 321

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  268 QIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLD---NQIKKDLADKESLENMMQRHEEEAHEKGKILS 344
Cdd:TIGR04523  322 KLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEekqNEIEKLKKENQSYKQEIKNLESQINDLESKIQ 401

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  345 EQKAMINAMDSKIRSLEQrivelsEANKLAANSSLFTQRNMKAQEEmISELRQQKFYLETQAGKLEAQNRKLEEQLEKIS 424
Cdd:TIGR04523  402 NQEKLNQQKDEQIKKLQQ------EKELLEKEIERLKETIIKNNSE-IKDLTNQDSVKELIIKNLDNTRESLETQLKVLS 474

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  425 HQDHSDKSRLLELETRLREVSLEHE---EQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKteleettaea 501
Cdd:TIGR04523  475 RSINKIKQNLEQKQKELKSKEKELKklnEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLE---------- 544

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  502 eeeiqaltahrDEIQRKFDALRNSC--TVITDLEEQLNQLTEDNAELNNQNFYLSKQLDeasgandeivQLRSEVDHLRR 579
Cdd:TIGR04523  545 -----------DELNKDDFELKKENleKEIDEKNKEIEELKQTQKSLKKKQEEKQELID----------QKEKEKKDLIK 603

                          570
                   ....*....|.
gi 1039770402  580 EITEREMQLTS 590
Cdd:TIGR04523  604 EIEEKEKKISS 614
PRK01156 PRK01156
chromosome segregation protein; Provisional
 44-602 2.14e-12

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 72.24  E-value: 2.14e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   44 LEQDLATYITECSSLKRSLEQarmevsqeDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEdlvsarrrS 123
Cdd:PRK01156   188 LEEKLKSSNLELENIKKQIAD--------DEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDM--------K 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  124 DLYESELR--ESRLAAEEFKR-KANECQHKLMKAKDQ----GKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEA 196
Cdd:PRK01156   252 NRYESEIKtaESDLSMELEKNnYYKELEERHMKIINDpvykNRNYINDYFKYKNDIENKKQILSNIDAEINKYHAIIKKL 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  197 TELlQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEErrhSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKI 276
Cdd:PRK01156   332 SVL-QKDYNDYIKKKSRYDDLNNQILELEGYEMDYNSYLK---SIESLKKKIEEYSKNIERMSAFISEILKIQEIDPDAI 407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  277 L-ELEEKHREAQ------VSAQHLEVHLKQKEQHYEEKIKVLDNQIK-----KDLADKESlENMMQRHEEEAHEKGKILS 344
Cdd:PRK01156   408 KkELNEINVKLQdisskvSSLNQRIRALRENLDELSRNMEMLNGQSVcpvcgTTLGEEKS-NHIINHYNEKKSRLEEKIR 486

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  345 EQKAMINAMDSKIRSLEQRI--VELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEK 422
Cdd:PRK01156   487 EIEIEVKDIDEKIVDLKKRKeyLESEEINKSINEYNKIESARADLEDIKIKINELKDKHDKYEEIKNRYKSLKLEDLDSK 566

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  423 ISHQDHSDKSR-LLELETrlrevsleHEEQKLELKRQLTELQLSLQERESQLTALQAAraaLESQLRQAKTELEETTAEA 501
Cdd:PRK01156   567 RTSWLNALAVIsLIDIET--------NRSRSNEIKKQLNDLESRLQEIEIGFPDDKSY---IDKSIREIENEANNLNNKY 635

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  502 EEeIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEA----SGANDEIVQLRSEVDHL 577
Cdd:PRK01156   636 NE-IQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDDAkanrARLESTIEILRTRINEL 714

                          570       580
                   ....*....|....*....|....*
gi 1039770402  578 RREITEREMQLTSQKQAQLSAPDLQ 602
Cdd:PRK01156   715 SDRINDINETLESMKKIKKAIGDLK 739
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 69-873 3.00e-12

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 72.02  E-value: 3.00e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   69 VSQEDDKALQLLHDIREQSRKLQEIkeqeyQAQVEEMRLMMNQLEEDLVSARRRSDLyESELRESRLAAEEFKRKANECQ 148
Cdd:TIGR02169  165 VAEFDRKKEKALEELEEVEENIERL-----DLIIDEKRQQLERLRREREKAERYQAL-LKEKREYEGYELLKEKEALERQ 238

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  149 HKLMKAkdqgkpevgEYSKLEKINAEQQLKIQELQEKLEKAVK-------------------------------ASTEAT 197
Cdd:TIGR02169  239 KEAIER---------QLASLEEELEKLTEEISELEKRLEEIEQlleelnkkikdlgeeeqlrvkekigeleaeiASLERS 309

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  198 --ELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVK----RLETMERRENRLKDDIQTKSEQIQQ 271
Cdd:TIGR02169  310 iaEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAelkeELEDLRAELEEVDKEFAETRDELKD 389

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  272 MADKILELEEKHREAQVSAQHLEVHLKQKEQHYEE---KIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKA 348
Cdd:TIGR02169  390 YREKLEKLKREINELKRELDRLQEELQRLSEELADlnaAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQ 469

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  349 MINAMDSKIRSLEQRIVELS---EANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEE-----QL 420
Cdd:TIGR02169  470 ELYDLKEEYDRVEKELSKLQrelAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQLGSVGERYATAIEvaagnRL 549

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  421 EKISHQDHSDKSRLLELETR----------LREVSLEHEEQKLELKRQLTELQLSLQERESQLtalqaaRAALESQLRQA 490
Cdd:TIGR02169  550 NNVVVEDDAVAKEAIELLKRrkagratflpLNKMRDERRDLSILSEDGVIGFAVDLVEFDPKY------EPAFKYVFGDT 623

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  491 KTELEETTAEAEEEIQALTAHRDEIQRK-------FDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGA 563
Cdd:TIGR02169  624 LVVEDIEAARRLMGKYRMVTLEGELFEKsgamtggSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENR 703

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  564 NDEIVQLRSEVDHLRREItEREMQLTSQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLG 643
Cdd:TIGR02169  704 LDELSQELSDASRKIGEI-EKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALN 782

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  644 DeksqfecrvreLQRMLDTEKQsraradQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAML 723
Cdd:TIGR02169  783 D-----------LEARLSHSRI------PEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDL 845

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  724 EMNARSLQQKLETERELKQRLLEEQAKLQQQmdlqknhifrltqgLQEALDRADLLKTERSDLEYQLENIQvlyshekvK 803
Cdd:TIGR02169  846 KEQIKSIEKEIENLNGKKEELEEELEELEAA--------------LRDLESRLGDLKKERDELEAQLRELE--------R 903

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039770402  804 MEGTISQQtklIDFLQAKMDQPAKKKKGLFSRRKE-DPALPTQVPlqYNELKLALEKEKARCAELEEALQK 873
Cdd:TIGR02169  904 KIEELEAQ---IEKKRKRLSELKAKLEALEEELSEiEDPKGEDEE--IPEEELSLEDVQAELQRVEEEIRA 969
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
155-595 3.79e-12

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 71.34  E-value: 3.79e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  155 KDQGKPEVGEYSKLEKinAEQQLK-IQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKkklvE 233
Cdd:COG4717     60 KPQGRKPELNLKELKE--LEEELKeAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQ----E 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  234 AEERRHSLENKVKRLETMERRENRLKD---DIQTKSEQIQQMADKILELEE-----KHREAQVSAQHLEvHLKQKEQHYE 305
Cdd:COG4717    134 LEALEAELAELPERLEELEERLEELREleeELEELEAELAELQEELEELLEqlslaTEEELQDLAEELE-ELQQRLAELE 212

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  306 EKIKVLDNQIKKDLADKESLENMMQRHEEEAH-EKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKL-AANSSLFTQR 383
Cdd:COG4717    213 EELEEAQEELEELEEELEQLENELEAAALEERlKEARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLvLGLLALLFLL 292

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  384 NMKAQEEMISELRQqkfyLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREV-----SLEHEEQKLELKRQ 458
Cdd:COG4717    293 LAREKASLGKEAEE----LQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELqellrEAEELEEELQLEEL 368

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  459 LTELQLSLQ--------------ERESQLTALQAARAALESQLRQAKTELEEttaeaeeeiQALTAHRDEIQRKFDALRN 524
Cdd:COG4717    369 EQEIAALLAeagvedeeelraalEQAEEYQELKEELEELEEQLEELLGELEE---------LLEALDEEELEEELEELEE 439

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039770402  525 SctvITDLEEQLNQLTEDNAELNNQNFYLSKQldeasganDEIVQLRSEVDHLRREITEREMQLTSQKQAQ 595
Cdd:COG4717    440 E---LEELEEELEELREELAELEAELEQLEED--------GELAELLQELEELKAELRELAEEWAALKLAL 499
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 57-828 3.83e-12

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 71.91  E-value: 3.83e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   57 SLKRSLEQARMEVSQEDDKALQLLHDIREQSRkLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESE--LRESR 134
Cdd:COG3096    289 ELRRELFGARRQLAEEQYRLVEMARELEELSA-RESDLEQDYQAASDHLNLVQTALRQQEKIERYQEDLEELTerLEEQE 367

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  135 LAAEEFKRKANECQHKLMKAKDqgkpevgEYSKLEKINAEQQLKIQELQeklekavkasTEATELlQNIRQAKERAEREL 214
Cdd:COG3096    368 EVVEEAAEQLAEAEARLEAAEE-------EVDSLKSQLADYQQALDVQQ----------TRAIQY-QQAVQALEKARALC 429

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  215 EK----LHNREDSSEGIKKKLVEAEERRHSLENKVkrletmerrenRLKDDIQTKSEQIQQMADKIL------------- 277
Cdd:COG3096    430 GLpdltPENAEDYLAAFRAKEQQATEEVLELEQKL-----------SVADAARRQFEKAYELVCKIAgeversqawqtar 498

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  278 ELEEKHREAQVSAQ---HLEVHLKQKEQHY------EEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKA 348
Cdd:COG3096    499 ELLRRYRSQQALAQrlqQLRAQLAELEQRLrqqqnaERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAAEAVE 578

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  349 MINAMDSKIRSLEQRIVELS--EANKLAANSSLFTQRNMKAQE----EMISELRQQKFYLETQA----GKLEAQNRKLEE 418
Cdd:COG3096    579 QRSELRQQLEQLRARIKELAarAPAWLAAQDALERLREQSGEAladsQEVTAAMQQLLEREREAtverDELAARKQALES 658

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  419 QLEKISHQDHSDKSRLLELETRLREV--SLEHEEQKLE-----------------------LKRQLTELQ-----LSLQE 468
Cdd:COG3096    659 QIERLSQPGGAEDPRLLALAERLGGVllSEIYDDVTLEdapyfsalygparhaivvpdlsaVKEQLAGLEdcpedLYLIE 738

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  469 R------ESQLTALQAARAAL----ESQLRQAKTELEET--TAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQL 536
Cdd:COG3096    739 GdpdsfdDSVFDAEELEDAVVvklsDRQWRYSRFPEVPLfgRAAREKRLEELRAERDELAEQYAKASFDVQKLQRLHQAF 818

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  537 NQLtednaelnnqnfyLSKQLDEASGANDE--IVQLRSEVDHLRREITEREMQLTSQKQAQLSA-PDLQTMEALKTTCTM 613
Cdd:COG3096    819 SQF-------------VGGHLAVAFAPDPEaeLAALRQRRSELERELAQHRAQEQQLRQQLDQLkEQLQLLNKLLPQANL 885

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  614 LEEQVL-----DLEALNDELLEKER----------QWEAWRSVLGDEKSQFEcrvrELQRMLDTEKQSRARADQRI---T 675
Cdd:COG3096    886 LADETLadrleELREELDAAQEAQAfiqqhgkalaQLEPLVAVLQSDPEQFE----QLQADYLQAKEQQRRLKQQIfalS 961

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  676 ESRQVVELAVKEHKAEIL----ALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKL 751
Cdd:COG3096    962 EVVQRRPHFSYEDAVGLLgensDLNEKLRARLEQAEEARREAREQLRQAQAQYSQYNQVLASLKSSRDAKQQTLQELEQE 1041

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039770402  752 QQQMDLQKNHifrltqglqEALDRAdllKTERSDLEYQLeniqvlyshekVKMEGTISQQTKLIDFLQAKMDQPAKK 828
Cdd:COG3096   1042 LEELGVQADA---------EAEERA---RIRRDELHEEL-----------SQNRSRRSQLEKQLTRCEAEMDSLQKR 1095
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 174-756 5.29e-12

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 70.97  E-value: 5.29e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  174 EQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSsegikkkLVEAEERRHSLENKVKRLET--- 250
Cdd:pfam01576    6 EMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETEL-------CAEAEEMRARLAARKQELEEilh 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  251 -MERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLE---VHLKQKEQHYEEKIKVLDNQIKKDLADKESLE 326
Cdd:pfam01576   79 eLESRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQlekVTTEAKIKKLEEDILLLEDQNSKLSKERKLLE 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  327 ---NMMQRHEEEAHEKGKILSEQKAMINAMdskirsleqrIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLE 403
Cdd:pfam01576  159 eriSEFTSNLAEEEEKAKSLSKLKNKHEAM----------ISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQ 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  404 TQAGKLEAQNRKLEEQL-------EKISHQDHSDKSRLLELETRLREV--SLEHE--------EQKLELKRQLTELQLSL 466
Cdd:pfam01576  229 AQIAELRAQLAKKEEELqaalarlEEETAQKNNALKKIRELEAQISELqeDLESEraarnkaeKQRRDLGEELEALKTEL 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  467 QERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTahrdeiQRKFDALRnsctvitDLEEQLNQLTEDNAEL 546
Cdd:pfam01576  309 EDTLDTTAAQQELRSKREQEVTELKKALEEETRSHEAQLQEMR------QKHTQALE-------ELTEQLEQAKRNKANL 375

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  547 NNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREIterEMQLtSQKQAQLSAPDLQTMEALKTTCTMLEEqvldLEALND 626
Cdd:pfam01576  376 EKAKQALESENAELQAELRTLQQAKQDSEHKRKKL---EGQL-QELQARLSESERQRAELAEKLSKLQSE----LESVSS 447

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  627 ELLEKERQweawRSVLGDEKSQFECRVRELQRMLDTEKQS--------RARADQRITESRQVVELAVKEHKAE--ILALQ 696
Cdd:pfam01576  448 LLNEAEGK----NIKLSKDVSSLESQLQDTQELLQEETRQklnlstrlRQLEDERNSLQEQLEEEEEAKRNVErqLSTLQ 523

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  697 QALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMD 756
Cdd:pfam01576  524 AQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELD 583
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 18-588 8.74e-12

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 70.53  E-value: 8.74e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   18 RRVSEVEAVLSQKEVELKAS----ETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEI 93
Cdd:pfam15921  317 RQLSDLESTVSQLRSELREAkrmyEDKIEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLE 396

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   94 KEQeyqaqveEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAeEFKRKANECQHKLMK--AKDQGKPEvgeysKLEKI 171
Cdd:pfam15921  397 KEQ-------NKRLWDRDTGNSITIDHLRRELDDRNMEVQRLEA-LLKAMKSECQGQMERqmAAIQGKNE-----SLEKV 463

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  172 NAeQQLKIQELQEKLEKAVKASTEATELLQNirqakerAERELEKL-HNREDSSEGIKKKLVEAEERRHSLENKVKRLET 250
Cdd:pfam15921  464 SS-LTAQLESTKEMLRKVVEELTAKKMTLES-------SERTVSDLtASLQEKERAIEATNAEITKLRSRVDLKLQELQH 535

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  251 MERRENRLKdDIQTKSEQIQqmadkiLELEEKHREAQVSAQHLEVHLKQKEQHYEE--KIKVLDNQIKKDLADKEsLEnm 328
Cdd:pfam15921  536 LKNEGDHLR-NVQTECEALK------LQMAEKDKVIEILRQQIENMTQLVGQHGRTagAMQVEKAQLEKEINDRR-LE-- 605

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  329 mqrheeeahekgkiLSEQKAMINAMDSKIRSLEQRIVELS-EANKLAANSSlftqRNMKAqeemISELRQQKFYLETQAG 407
Cdd:pfam15921  606 --------------LQEFKILKDKKDAKIRELEARVSDLElEKVKLVNAGS----ERLRA----VKDIKQERDQLLNEVK 663

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  408 KLEAQNRKLEEQLEKishqdhsdksrlleLETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARA-ALESQ 486
Cdd:pfam15921  664 TSRNELNSLSEDYEV--------------LKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGhAMKVA 729

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  487 LRQAKTeleettaeaeeeiqaLTAHRDEIqrkfDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQLD----EASG 562
Cdd:pfam15921  730 MGMQKQ---------------ITAKRGQI----DALQSK---IQFLEEAMTNANKEKHFLKEEKNKLSQELStvatEKNK 787

                          570       580
                   ....*....|....*....|....*.
gi 1039770402  563 ANDEIVQLRSEVDHLRREITEREMQL 588
Cdd:pfam15921  788 MAGELEVLRSQERRLKEKVANMEVAL 813
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
304-889 1.40e-11

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 69.71  E-value: 1.40e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  304 YEEKIKVLDNQIKKDLADKESLENMMQRhEEEAHEKgkiLSEQKAMINAMDSKIRSLEQRIVELSEanKLAANSSLFtqR 383
Cdd:PRK03918   160 YENAYKNLGEVIKEIKRRIERLEKFIKR-TENIEEL---IKEKEKELEEVLREINEISSELPELRE--ELEKLEKEV--K 231

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  384 NMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIshqdhsdKSRLLELETRLREV-SLEHEEQK-LELKRQLTE 461
Cdd:PRK03918   232 ELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEEL-------KKEIEELEEKVKELkELKEKAEEyIKLSEFYEE 304

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  462 LQLSLQERESQLTALQAARAALESQLRQAKTELEEttaeaeeeIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTE 541
Cdd:PRK03918   305 YLDELREIEKRLSRLEEEINGIEERIKELEEKEER--------LEELKKKLKELEKRLEELEERHELYEEAKAKKEELER 376

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  542 DNAELNNQNF-YLSKQLDEASGAN----DEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTCTMLEE 616
Cdd:PRK03918   377 LKKRLTGLTPeKLEKELEELEKAKeeieEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEHRKELLEE 456

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  617 QVLDLEALNDELLEkerqweawrsvLGDEKSQFECRVRELQRMLdtEKQSRARADQRITESRQVVELAVKEHKAEILA-- 694
Cdd:PRK03918   457 YTAELKRIEKELKE-----------IEEKERKLRKELRELEKVL--KKESELIKLKELAEQLKELEEKLKKYNLEELEkk 523

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  695 --LQQALKEQ--KLKAESLS-----DKLNDLEKKHAMLEMNARSLQQKLEterELKQRLLEEQAKLQQQMDLQknhifrl 765
Cdd:PRK03918   524 aeEYEKLKEKliKLKGEIKSlkkelEKLEELKKKLAELEKKLDELEEELA---ELLKELEELGFESVEELEER------- 593

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  766 TQGLQEALDRADLLKTERSDLEYQLENIQVLYShEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDpalptq 845
Cdd:PRK03918   594 LKELEPFYNEYLELKDAEKELEREEKELKKLEE-ELDKAFEELAETEKRLEELRKELEELEKKYSEEEYEELRE------ 666

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....
gi 1039770402  846 vplQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRK 889
Cdd:PRK03918   667 ---EYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEERE 707
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 9-424 1.90e-11

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 68.89  E-value: 1.90e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402    9 MEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSR 88
Cdd:TIGR04523  216 LESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKS 295

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   89 KLQEIKEQEYQAqveemrlMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLM------KAKDQGKPEv 162
Cdd:TIGR04523  296 EISDLNNQKEQD-------WNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTnsesenSEKQRELEE- 367

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  163 gEYSKLEKINAEQQLKIQELQeKLEkavkasTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLE 242
Cdd:TIGR04523  368 -KQNEIEKLKKENQSYKQEIK-NLE------SQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNN 439

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  243 NKVKRLETMERRENRLKDDIQTKSEQIQQmadKILELEEKHREAQVSAQHLEVHLKQKEQHYE---EKIKVLDNQIKKDL 319
Cdd:TIGR04523  440 SEIKDLTNQDSVKELIIKNLDNTRESLET---QLKVLSRSINKIKQNLEQKQKELKSKEKELKklnEEKKELEEKVKDLT 516

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  320 ADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDS---------KIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEE 390
Cdd:TIGR04523  517 KKISSLKEKIEKLESEKKEKESKISDLEDELNKDDFelkkenlekEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEK 596

                          410       420       430
                   ....*....|....*....|....*....|....
gi 1039770402  391 MISELRQQKFYLETQAGKLEAQNRKLEEQLEKIS 424
Cdd:TIGR04523  597 EKKDLIKEIEEKEKKISSLEKELEKAKKENEKLS 630
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 207-890 2.12e-11

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 69.33  E-value: 2.12e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  207 KERAERELEKLHNREDSSEGIKKKLVE-----AEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEE 281
Cdd:TIGR02169  172 KEKALEELEEVEENIERLDLIIDEKRQqlerlRREREKAERYQALLKEKREYEGYELLKEKEALERQKEAIERQLASLEE 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  282 KHREAQVSAQHLEVHLKQKEQHYEE---KIKVLD----NQIKKDLADKESLENMMQRHEEEAHEKGKILSEQ----KAMI 350
Cdd:TIGR02169  252 ELEKLTEEISELEKRLEEIEQLLEElnkKIKDLGeeeqLRVKEKIGELEAEIASLERSIAEKERELEDAEERlaklEAEI 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  351 NAMDSKIRSLEQRIVElsEANKLAANSSLFtqrnmKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHS- 429
Cdd:TIGR02169  332 DKLLAEIEELEREIEE--ERKRRDKLTEEY-----AELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINEl 404

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  430 --DKSRLLELETRLREVSLEH-------EEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAE 500
Cdd:TIGR02169  405 krELDRLQEELQRLSEELADLnaaiagiEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKE 484

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  501 AEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDhlrre 580
Cdd:TIGR02169  485 LSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQLGSVGERYATAIEVAAGNRLNNVVVEDDAV----- 559

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  581 iTEREMQLTSQKQAQ----LSAPDLQTMEALKTtcTMLEEQVLDLeALNdeLLEKERQWE-AWRSVLGDEK--SQFECRV 653
Cdd:TIGR02169  560 -AKEAIELLKRRKAGratfLPLNKMRDERRDLS--ILSEDGVIGF-AVD--LVEFDPKYEpAFKYVFGDTLvvEDIEAAR 633

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  654 RELQ--RM--LDTE------------KQSRARADQRITESRQVVELA--VKEHKAEILALQQALKEQKLKAESLSDKLND 715
Cdd:TIGR02169  634 RLMGkyRMvtLEGElfeksgamtggsRAPRGGILFSRSEPAELQRLRerLEGLKRELSSLQSELRRIENRLDELSQELSD 713

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  716 LEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLT---QGLQEALD--RADLLKTERSDLEYQL 790
Cdd:TIGR02169  714 ASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEariEELEEDLHklEEALNDLEARLSHSRI 793

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  791 ENIQVLYShekvKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEA 870
Cdd:TIGR02169  794 PEIQAELS----KLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEE 869

                          730       740
                   ....*....|....*....|
gi 1039770402  871 LQKTRIELRSAREEAAHRKA 890
Cdd:TIGR02169  870 LEELEAALRDLESRLGDLKK 889
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 564-889 3.06e-11

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 68.54  E-value: 3.06e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  564 NDEIVQLRSEVDHLRR--EITEREMQLTSQK---QAQLSAPDLQTMEA-LKTTCTMLEEQVLDLEALNDELLEKERQWEA 637
Cdd:TIGR02168  192 EDILNELERQLKSLERqaEKAERYKELKAELrelELALLVLRLEELREeLEELQEELKEAEEELEELTAELQELEEKLEE 271

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  638 WRsvlgDEKSQFECRVRELQRMLDTEKQSRARADQRI---TESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLN 714
Cdd:TIGR02168  272 LR----LEVSELEEEIEELQKELYALANEISRLEQQKqilRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLE 347

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  715 DLEKKHAMLEM---NARSLQQKLETERELKQRLLEEQ----AKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLE 787
Cdd:TIGR02168  348 ELKEELESLEAeleELEAELEELESRLEELEEQLETLrskvAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELL 427

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  788 YQLENiqvlysHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEdpalptqVPLQYNELKLALEKEKARCAEL 867
Cdd:TIGR02168  428 KKLEE------AELKELQAELEELEEELEELQEELERLEEALEELREELEE-------AEQALDAAERELAQLQARLDSL 494

                          330       340
                   ....*....|....*....|..
gi 1039770402  868 EEALQKTRIELRSAREEAAHRK 889
Cdd:TIGR02168  495 ERLQENLEGFSEGVKALLKNQS 516
PRK01156 PRK01156
chromosome segregation protein; Provisional
 256-759 3.25e-11

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 68.39  E-value: 3.25e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  256 NRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYeekikvldNQIKKDLADKESLENMMQRHEEE 335
Cdd:PRK01156   186 DYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDY--------NNLKSALNELSSLEDMKNRYESE 257

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  336 AHEkgkiLSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQeemISELRQQKFYLETQAGKLEAQNRK 415
Cdd:PRK01156   258 IKT----AESDLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKND---IENKKQILSNIDAEINKYHAIIKK 330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  416 LEEqLEKISHQDHSDKSRLLELETRLREVSLEH-----------------EEQKLELKRQLTELQLSLQERESQLTALQA 478
Cdd:PRK01156   331 LSV-LQKDYNDYIKKKSRYDDLNNQILELEGYEmdynsylksieslkkkiEEYSKNIERMSAFISEILKIQEIDPDAIKK 409

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  479 ARAALESQLRQakteLEETTAEAEEEIQALTAHRDEIQRKFDAL--RNSCTVI-TDL-EEQLNQLTED-NAELNNQNFYL 553
Cdd:PRK01156   410 ELNEINVKLQD----ISSKVSSLNQRIRALRENLDELSRNMEMLngQSVCPVCgTTLgEEKSNHIINHyNEKKSRLEEKI 485

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  554 SKQLDEASGANDEIVQLRSEVDHL------------------RREITEREMQLTSQKQAQLSAP---------DLQTMEA 606
Cdd:PRK01156   486 REIEIEVKDIDEKIVDLKKRKEYLeseeinksineynkiesaRADLEDIKIKINELKDKHDKYEeiknrykslKLEDLDS 565

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  607 LKTTCTMLEEQV--LDLEALNDELLEKERQWEAWRSVLG-------DEKSQFECRVRELQRMLDT--EKQSRARADQRIT 675
Cdd:PRK01156   566 KRTSWLNALAVIslIDIETNRSRSNEIKKQLNDLESRLQeieigfpDDKSYIDKSIREIENEANNlnNKYNEIQENKILI 645

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  676 ESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETER----ELKQRLLEEQAKL 751
Cdd:PRK01156   646 EKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEILRtrinELSDRINDINETL 725


                   ....*...
gi 1039770402  752 QQQMDLQK 759
Cdd:PRK01156   726 ESMKKIKK 733
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 127-747 3.32e-11

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 68.21  E-value: 3.32e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  127 ESELRESRLAAEEfKRKANECQHKLMKAKDQGKpevgeysklEKINAEQQLKIQElQEKLEKAVKASTEATELLQNI--R 204
Cdd:pfam05483   98 EAELKQKENKLQE-NRKIIEAQRKAIQELQFEN---------EKVSLKLEEEIQE-NKDLIKENNATRHLCNLLKETcaR 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  205 QAKERAERELEKLHNRE---DSSEGIKKKLVEAEERRHSLEN-------KVKR-LETMERRENRLKDDIQTKSEQIQQMA 273
Cdd:pfam05483  167 SAEKTKKYEYEREETRQvymDLNNNIEKMILAFEELRVQAENarlemhfKLKEdHEKIQHLEEEYKKEINDKEKQVSLLL 246

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  274 DKILELEEKHREAQVsaqhLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMqrhEEEAHEKGKILSEQKAMINAM 353
Cdd:pfam05483  247 IQITEKENKMKDLTF----LLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKEL---EDIKMSLQRSMSTQKALEEDL 319

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  354 DSKIRSL----EQRIVELSEANKLAANSSLFT---QRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQ 426
Cdd:pfam05483  320 QIATKTIcqltEEKEAQMEELNKAKAAHSFVVtefEATTCSLEELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKF 399

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  427 DHSDKSRLLELETRLREVSLEHEEQKL------ELKRQLTELQLSLQERES-------QLTALQAARAALESQLRQAKTE 493
Cdd:pfam05483  400 KNNKEVELEELKKILAEDEKLLDEKKQfekiaeELKGKEQELIFLLQAREKeihdleiQLTAIKTSEEHYLKEVEDLKTE 479

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  494 LEETTAEAEEeiqaLTAHRDEIQRKFDALRNSCtviTDLEEQLNQLTEDnaeLNNQNFYLSKQLDEASGANDEIVQLRSE 573
Cdd:pfam05483  480 LEKEKLKNIE----LTAHCDKLLLENKELTQEA---SDMTLELKKHQED---IINCKKQEERMLKQIENLEEKEMNLRDE 549

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  574 VDHLRREITEREMQL-----TSQKQAQLSAPDL----QTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGD 644
Cdd:pfam05483  550 LESVREEFIQKGDEVkckldKSEENARSIEYEVlkkeKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENK 629

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  645 EKSQFECRVRELQRMLDTEKQ---------SRARADQRITE---------SRQVVELAVK---------EHK-AEILALQ 696
Cdd:pfam05483  630 QLNAYEIKVNKLELELASAKQkfeeiidnyQKEIEDKKISEeklleevekAKAIADEAVKlqkeidkrcQHKiAEMVALM 709

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770402  697 QALKEQ---------------KLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEE 747
Cdd:pfam05483  710 EKHKHQydkiieerdselglyKNKEQEQSSAKAALEIELSNIKAELLSLKKQLEIEKEEKEKLKME 775
mukB PRK04863
chromosome partition protein MukB;
81-794 4.65e-11

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 68.06  E-value: 4.65e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   81 HDIREQSRKLQEIK------EQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELR--ESRLAAEEFKRKANECQHKLM 152
Cdd:PRK04863   307 YRLVEMARELAELNeaesdlEQDYQAASDHLNLVQTALRQQEKIERYQADLEELEERleEQNEVVEEADEQQEENEARAE 386

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  153 KAKDqgkpevgEYSKLEKINAEQQLKIQELQEK---LEKAVKASTEATELLQNIRQAKERAERELEKLHNREDssegikk 229
Cdd:PRK04863   387 AAEE-------EVDELKSQLADYQQALDVQQTRaiqYQQAVQALERAKQLCGLPDLTADNAEDWLEEFQAKEQ------- 452

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  230 klvEAEERRHSLENKVkrletmerrenRLKDDIQTKSEQIQQMADKIL-------------ELEEKHREAQ---VSAQHL 293
Cdd:PRK04863   453 ---EATEELLSLEQKL-----------SVAQAAHSQFEQAYQLVRKIAgevsrseawdvarELLRRLREQRhlaEQLQQL 518

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  294 EVHLKQKEQHYEEKIKV--LDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIR----SLEQRIVEL 367
Cdd:PRK04863   519 RMRLSELEQRLRQQQRAerLLAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVSEARERRMALRqqleQLQARIQRL 598

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  368 S--EANKLAANSSLFTQRNMKAQE----EMISELRQQKFYLETQA----GKLEAQNRKLEEQLEKISHQDHSDKSRLLEL 437
Cdd:PRK04863   599 AarAPAWLAAQDALARLREQSGEEfedsQDVTEYMQQLLERERELtverDELAARKQALDEEIERLSQPGGSEDPRLNAL 678

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  438 ETRLREVSLE--HEEQKLE-----------------------LKRQLTELQ-----LSLQE------RESQLTALQAARA 481
Cdd:PRK04863   679 AERFGGVLLSeiYDDVSLEdapyfsalygparhaivvpdlsdAAEQLAGLEdcpedLYLIEgdpdsfDDSVFSVEELEKA 758

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  482 AL----ESQLRQAKTELEET--TAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTednaelnNQNFYLSK 555
Cdd:PRK04863   759 VVvkiaDRQWRYSRFPEVPLfgRAAREKRIEQLRAEREELAERYATLSFDVQKLQRLHQAFSRFI-------GSHLAVAF 831

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  556 QLDEasgaNDEIVQLRSEVDHLRREITEREMQLTSQKQAqlsapdlqtMEALKTTCTMLEE-----QVLDLEALNDELLE 630
Cdd:PRK04863   832 EADP----EAELRQLNRRRVELERALADHESQEQQQRSQ---------LEQAKEGLSALNRllprlNLLADETLADRVEE 898

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  631 KERQWEAWR--------------------SVLGDEKSQFEcrvrELQRMLDTEKQSRARADQRI---TESRQVVELAVKE 687
Cdd:PRK04863   899 IREQLDEAEeakrfvqqhgnalaqlepivSVLQSDPEQFE----QLKQDYQQAQQTQRDAKQQAfalTEVVQRRAHFSYE 974

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  688 HKAEILA----LQQALKEQKLKAESLSDKLNDLEKKHA--MLEMNAR------SLQQKLETERELKQRL----------L 745
Cdd:PRK04863   975 DAAEMLAknsdLNEKLRQRLEQAEQERTRAREQLRQAQaqLAQYNQVlaslksSYDAKRQMLQELKQELqdlgvpadsgA 1054

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*....
gi 1039770402  746 EEQAKLQQQmdlqknhifRLTQGLQEALDRADLLKTERSDLEYQLENIQ 794
Cdd:PRK04863  1055 EERARARRD---------ELHARLSANRSRRNQLEKQLTFCEAEMDNLT 1094
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
132-752 6.43e-11

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 67.37  E-value: 6.43e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  132 ESRLAAEEFKRKANECQHKLmKAKDQGKPEVGEYSKL---EKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKE 208
Cdd:PRK02224   173 DARLGVERVLSDQRGSLDQL-KAQIEEKEEKDLHERLnglESELAELDEEIERYEEQREQARETRDEADEVLEEHEERRE 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  209 RAER---ELEKLhnREDSSEGIKKKLVEAEERRhslENKVKRLETMERRENRLKD------DIQTKSEQIQQMADKILEL 279
Cdd:PRK02224   252 ELETleaEIEDL--RETIAETEREREELAEEVR---DLRERLEELEEERDDLLAEaglddaDAEAVEARREELEDRDEEL 326

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  280 EEKHREAQVSAQHlevHLKQKEQhYEEKIKVLDNQIKKDLADKESLENMMQRHEEEahekgkiLSEQKAMINAMDSKIRS 359
Cdd:PRK02224   327 RDRLEECRVAAQA---HNEEAES-LREDADDLEERAEELREEAAELESELEEAREA-------VEDRREEIEELEEEIEE 395

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  360 LEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQkfyLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELEt 439
Cdd:PRK02224   396 LRERFGDAPVDLGNAEDFLEELREERDELREREAELEAT---LRTARERVEEAEALLEAGKCPECGQPVEGSPHVETIE- 471

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  440 rlrevslEHEEQKLELKRQLTELQLSLQERESQLTALQAARAAlESQLRQAKTELEETTaeaeeeiQALTAHRDEIQRKf 519
Cdd:PRK02224   472 -------EDRERVEELEAELEDLEEEVEEVEERLERAEDLVEA-EDRIERLEERREDLE-------ELIAERRETIEEK- 535

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  520 dalrnsctvitdlEEQLNQLTEDNAELNnqnfylskqlDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAqlsap 599
Cdd:PRK02224   536 -------------RERAEELRERAAELE----------AEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKER----- 587

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  600 dLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSqfecRVRELQRMLDTEKQSRARADQRITESRQ 679
Cdd:PRK02224   588 -IESLERIRTLLAAIADAEDEIERLREKREALAELNDERRERLAEKRE----RKRELEAEFDEARIEEAREDKERAEEYL 662

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039770402  680 vvelavkehkaeilalqqalkeqklkaESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQ 752
Cdd:PRK02224   663 ---------------------------EQVEEKLDELREERDDLQAEIGAVENELEELEELRERREALENRVE 708
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 620-890 6.95e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 67.27  E-value: 6.95e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  620 DLEALNDELLEKERQWEAwrsvLGDEKSQFEcRVRELQRMLDT-EKQSRARADQRITESRQVVELAVKEHKAEILALQQ- 697
Cdd:COG1196    187 NLERLEDILGELERQLEP----LERQAEKAE-RYRELKEELKElEAELLLLKLRELEAELEELEAELEELEAELEELEAe 261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  698 ------ALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQE 771
Cdd:COG1196    262 laeleaELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEE 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  772 ALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDpalptqvpLQYN 851
Cdd:COG1196    342 LEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAE--------EALL 413

                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 1039770402  852 ELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKA 890
Cdd:COG1196    414 ERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEA 452
C1_ScPKC1-like_rpt2 cd20823
second protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae ...
 951-1008 7.42e-11

second protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae protein kinase C-like 1 (ScPKC1) and similar proteins; ScPKC1 is required for cell growth and for the G2 to M transition of the cell division cycle. It mediates a protein kinase cascade, activating BCK1 which itself activates MKK1/MKK2. The family also includes Schizosaccharomyces pombe PKC1 and PKC2, which are involved in the control of cell shape and act as targets of the inhibitor staurosporine. Members of this family contain two copies of C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410373  Cd Length: 59  Bit Score: 58.86  E-value: 7.42e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1039770402  951 HNIPHRFNVGLNMRATKCAVCLDTVHFGR-QASKCLECQVMCHPKCSTCLPATCGLPAE 1008
Cdd:cd20823      1 HRIPHRFEPFTNLGANWCCHCGQMLPLGRkQIRKCTECGKTAHAQCAHLVPNFCGLSME 59
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 212-806 9.48e-11

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 67.12  E-value: 9.48e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  212 RELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLetMERReNRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQ 291
Cdd:pfam01576    2 RQEEEMQAKEEELQKVKERQQKAESELKELEKKHQQL--CEEK-NALQEQLQAETELCAEAEEMRARLAARKQELEEILH 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  292 HLEVHLKQKeqhyEEKIKVLDNQIKKDLADKESLENmmQRHEEEAhekgkilSEQKAMIN--AMDSKIRSLEQRIVELSE 369
Cdd:pfam01576   79 ELESRLEEE----EERSQQLQNEKKKMQQHIQDLEE--QLDEEEA-------ARQKLQLEkvTTEAKIKKLEEDILLLED 145

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  370 AN-KLaansslftQRNMKAQEEMISELRQQKFYLETQAGKL-------EAQNRKLEEQLEKishqDHSDKSRLLELETRL 441
Cdd:pfam01576  146 QNsKL--------SKERKLLEERISEFTSNLAEEEEKAKSLsklknkhEAMISDLEERLKK----EEKGRQELEKAKRKL 213

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  442 REVSLEHEEQKLELKRQLTELQLSLQERESQLTALQaARAALESQLRQAkteleettaeAEEEIQALTAHRDEIQRKFDA 521
Cdd:pfam01576  214 EGESTDLQEQIAELQAQIAELRAQLAKKEEELQAAL-ARLEEETAQKNN----------ALKKIRELEAQISELQEDLES 282

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  522 LRNSCTVIT----DLEEQLNQLTEDnaelnnqnfyLSKQLDEASGANDEIVQLRSEVDHLRREITERemqlTSQKQAQLS 597
Cdd:pfam01576  283 ERAARNKAEkqrrDLGEELEALKTE----------LEDTLDTTAAQQELRSKREQEVTELKKALEEE----TRSHEAQLQ 348

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  598 apdlqtmealkttcTMLEEQVLDLEALNDELLEKER---QWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQri 674
Cdd:pfam01576  349 --------------EMRQKHTQALEELTEQLEQAKRnkaNLEKAKQALESENAELQAELRTLQQAKQDSEHKRKKLEG-- 412

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  675 tesrQVVELAVKEHKAEILALQQALKEQKLKAE--SLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRllEEQAKLQ 752
Cdd:pfam01576  413 ----QLQELQARLSESERQRAELAEKLSKLQSEleSVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQE--ETRQKLN 486

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1039770402  753 -----QQMDLQKNhifrltqGLQEALDRADllkTERSDLEYQLENIQVLYSHEKVKMEG 806
Cdd:pfam01576  487 lstrlRQLEDERN-------SLQEQLEEEE---EAKRNVERQLSTLQAQLSDMKKKLEE 535
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
2-454 9.58e-11

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 67.01  E-value: 9.58e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402    2 LLGEEAMMEQEMTRLHRRVSEVEAVLSQ---KEVELKASETQRSLLEQDLAtyitecsSLKRSLEqarmevsqEDDKALQ 78
Cdd:PRK03918   305 YLDELREIEKRLSRLEEEINGIEERIKEleeKEERLEELKKKLKELEKRLE-------ELEERHE--------LYEEAKA 369

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   79 LLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANEC--------QHK 150
Cdd:PRK03918   370 KKEELERLKKRLTGLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCpvcgreltEEH 449

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  151 LMKAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAER----ELEKLHNREDSSEG 226
Cdd:PRK03918   450 RKELLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKLKELAEQLKELEEKlkkyNLEELEKKAEEYEK 529

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  227 IKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKhreaqvSAQHLEVHLKQKEQHYEE 306
Cdd:PRK03918   530 LKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELGFE------SVEELEERLKELEPFYNE 603

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  307 KIKVLDnqIKKDLadkESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVElsEANKLAANSSLFTQRNMK 386
Cdd:PRK03918   604 YLELKD--AEKEL---EREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSE--EEYEELREEYLELSRELA 676

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770402  387 AQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSdKSRLLELETRLREVSLEHEEQKLE 454
Cdd:PRK03918   677 GLRAELEELEKRREEIKKTLEKLKEELEEREKAKKELEKLEKA-LERVEELREKVKKYKALLKERALS 743
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
111-543 1.23e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 66.33  E-value: 1.23e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  111 QLEEDLVSARRRSDLY---ESELRESRLAAEEFKRKANECQHKL--MKAKDQGKPEVGEYSKLEKINAEQQLKIQELQEK 185
Cdd:COG4717     75 ELEEELKEAEEKEEEYaelQEELEELEEELEELEAELEELREELekLEKLLQLLPLYQELEALEAELAELPERLEELEER 154

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  186 LEKAVKASTEATELLQNIRQAKERAERELEKLhnredsSEGIKKKLVEAEERRHSLENKVKRLetmERRENRLKDDIQTK 265
Cdd:COG4717    155 LEELRELEEELEELEAELAELQEELEELLEQL------SLATEEELQDLAEELEELQQRLAEL---EEELEEAQEELEEL 225

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  266 SEQIQQMADKILELEEKHR-------------------------------------EAQVSAQHLEVHLKQKEQHYEEKI 308
Cdd:COG4717    226 EEELEQLENELEAAALEERlkearlllliaaallallglggsllsliltiagvlflVLGLLALLFLLLAREKASLGKEAE 305

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  309 KVLDNQIKKDLADKEsLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQ 388
Cdd:COG4717    306 ELQALPALEELEEEE-LEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALLAEAGVEDE 384

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  389 EEMISELRQQKFYLETQAgKLEAQNRKLEEQLEKISHQ-DHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQ 467
Cdd:COG4717    385 EELRAALEQAEEYQELKE-ELEELEEQLEELLGELEELlEALDEEELEEELEELEEELEELEEELEELREELAELEAELE 463

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770402  468 ERESQ--LTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKfdalrnsctVITDLEEQLNQLTEDN 543
Cdd:COG4717    464 QLEEDgeLAELLQELEELKAELRELAEEWAALKLALELLEEAREEYREERLPP---------VLERASEYFSRLTDGR 532
C1 smart00109
Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol ...
 955-1003 1.79e-10

Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol esters and diacylglycerol. Some bind RasGTP. Zinc-binding domains.


Pssm-ID: 197519  Cd Length: 50  Bit Score: 57.48  E-value: 1.79e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 1039770402   955 HRFNVGLNMRATKCAVCLDTVHFGR-QASKCLECQVMCHPKCSTCLPATC 1003
Cdd:smart00109    1 HKHVFRTFTKPTFCCVCRKSIWGSFkQGLRCSECKVKCHKKCADKVPKAC 50
C1 cd00029
protein kinase C conserved region 1 (C1 domain) superfamily; The C1 domain is a cysteine-rich ...
 955-1003 1.85e-10

protein kinase C conserved region 1 (C1 domain) superfamily; The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains. It contains the motif HX12CX2CXnCX2CX4HX2CX7C, where C and H are cysteine and histidine, respectively; X represents other residues; and n is either 13 or 14. C1 has a globular fold with two separate Zn(2+)-binding sites. It was originally discovered as lipid-binding modules in protein kinase C (PKC) isoforms. C1 domains that bind and respond to phorbol esters (PE) and diacylglycerol (DAG) are referred to as typical, and those that do not respond to PE and DAG are deemed atypical. A C1 domain may also be referred to as PKC or non-PKC C1, based on the parent protein's activity. Most C1 domain-containing non-PKC proteins act as lipid kinases and scaffolds, except PKD which acts as a protein kinase. PKC C1 domains play roles in membrane translocation and activation of the enzyme.


Pssm-ID: 410341  Cd Length: 50  Bit Score: 57.53  E-value: 1.85e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1039770402  955 HRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 1003
Cdd:cd00029      1 HRFVPTTFSSPTFCDVCGKLIwGLFKQGLKCSDCGLVCHKKCLDKAPSPC 50
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
416-885 2.11e-10

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 65.83  E-value: 2.11e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  416 LEEQLEKISHQDHSDksRLLELETRLREVS--LEH-EEQKLELKRQLTELQLSLQERESQLTALQAARAALEsQLRQAKT 492
Cdd:PRK02224   192 LKAQIEEKEEKDLHE--RLNGLESELAELDeeIERyEEQREQARETRDEADEVLEEHEERREELETLEAEIE-DLRETIA 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  493 ELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTV----ITDLEEQLNQLTEDNAE----LNNQNFYLSKQLDEASGAN 564
Cdd:PRK02224   269 ETEREREELAEEVRDLRERLEELEEERDDLLAEAGLddadAEAVEARREELEDRDEElrdrLEECRVAAQAHNEEAESLR 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  565 DEIVQLRSEVDHLRREITEREMQLTSQKQA------QLSAPDLQtMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAW 638
Cdd:PRK02224   349 EDADDLEERAEELREEAAELESELEEAREAvedrreEIEELEEE-IEELRERFGDAPVDLGNAEDFLEELREERDELRER 427

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  639 RSVLGDEKSQFECRVRELQRMLDTEKQSRAraDQRITESRQVVELAVKEHKAEILALQqaLKEQKLKAESLSDKLN---- 714
Cdd:PRK02224   428 EAELEATLRTARERVEEAEALLEAGKCPEC--GQPVEGSPHVETIEEDRERVEELEAE--LEDLEEEVEEVEERLEraed 503

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  715 --DLEKKHAMLEMNARSLQQKLET-------ERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSD 785
Cdd:PRK02224   504 lvEAEDRIERLEERREDLEELIAErretieeKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAE 583

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  786 LEYQLENIqvlyshekvkmeGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRkedpalptqvplqyNELKLALEKEKARCA 865
Cdd:PRK02224   584 LKERIESL------------ERIRTLLAAIADAEDEIERLREKREALAELN--------------DERRERLAEKRERKR 637

                          490       500
                   ....*....|....*....|.
gi 1039770402  866 ELEEALQKTRIE-LRSAREEA 885
Cdd:PRK02224   638 ELEAEFDEARIEeAREDKERA 658
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 2-756 2.87e-10

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 65.58  E-value: 2.87e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402    2 LLGEEAMMEQEMTR---LHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQarmevSQEDDKALQ 78
Cdd:pfam01576  245 LQAALARLEEETAQknnALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTELED-----TLDTTAAQQ 319

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   79 LLHDIREQS----RKLQEIKEQEYQAQVEEMRLMMNQ----LEEDLVSARR-RSDL------YESELRESRLAAEEFKRK 143
Cdd:pfam01576  320 ELRSKREQEvtelKKALEEETRSHEAQLQEMRQKHTQaleeLTEQLEQAKRnKANLekakqaLESENAELQAELRTLQQA 399

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  144 ANECQHKLMKAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLE-----------KAVKASTEATEL------LQNIRQA 206
Cdd:pfam01576  400 KQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELEsvssllneaegKNIKLSKDVSSLesqlqdTQELLQE 479

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  207 KERAERELE-KLHNREDSSEGIKKKLVEAEERRHSLENKVKRL------------------ETMERRENRLKDDIQTKSE 267
Cdd:pfam01576  480 ETRQKLNLStRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLqaqlsdmkkkleedagtlEALEEGKKRLQRELEALTQ 559

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  268 QIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQ---HYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEK-GKIL 343
Cdd:pfam01576  560 QLEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQlvsNLEKKQKKFDQMLAEEKAISARYAEERDRAEAEAREKeTRAL 639

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  344 SEQKAMINAMDSKirsleqriVELSEANKL--AANSSLFTQRNMKAQEemISELRQQKFYLETQAGKLEAQNRKLEEQLe 421
Cdd:pfam01576  640 SLARALEEALEAK--------EELERTNKQlrAEMEDLVSSKDDVGKN--VHELERSKRALEQQVEEMKTQLEELEDEL- 708

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  422 kishQDHSDKSRLLELETRLREVSLEH---------EEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKT 492
Cdd:pfam01576  709 ----QATEDAKLRLEVNMQALKAQFERdlqardeqgEEKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEA 784

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  493 ELEETTAEAEEEIQAL---TAHRDEIQRKFDALRNSCTVI-----------TDLEEQLNQLTEDNA-------------- 544
Cdd:pfam01576  785 QIDAANKGREEAVKQLkklQAQMKDLQRELEEARASRDEIlaqskesekklKNLEAELLQLQEDLAaserarrqaqqerd 864

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  545 ----ELNNQNFYLSKQLDEASGANDEIVQLRSEvdhLRREITEREMQLTSQKQAQLSAPDLQT-MEALKTTCTMLEEQVL 619
Cdd:pfam01576  865 eladEIASGASGKSALQDEKRRLEARIAQLEEE---LEEEQSNTELLNDRLRKSTLQVEQLTTeLAAERSTSQKSESARQ 941

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  620 DLEALNDELLEKERQWE-AWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITEsrqvvelavKEHKAEILALQqa 698
Cdd:pfam01576  942 QLERQNKELKAKLQEMEgTVKSKFKSSIAALEAKIAQLEEQLEQESRERQAANKLVRR---------TEKKLKEVLLQ-- 1010

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770402  699 LKEQKLKAESLSDKLndlEKKHAMLemnaRSLQQKLETERELKQRLLEEQAKLQQQMD 756
Cdd:pfam01576 1011 VEDERRHADQYKDQA---EKGNSRM----KQLKRQLEEAEEEASRANAARRKLQRELD 1061
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
325-561 3.57e-10

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 64.65  E-value: 3.57e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  325 LENMMQRHEEEAHEKGKILSEQkamINAMDSKIRSLEQRIVELSEANKLAAnsslfTQRNMKAQEEMISELRQQKFYLET 404
Cdd:COG3206    162 LEQNLELRREEARKALEFLEEQ---LPELRKELEEAEAALEEFRQKNGLVD-----LSEEAKLLLQQLSELESQLAEARA 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  405 QAGKLEAQNRKLEEQLEKISHQ--DHSDKSRLLELETRLREvsleheeqkleLKRQLTELQLSLQERESQLTALQAARAA 482
Cdd:COG3206    234 ELAEAEARLAALRAQLGSGPDAlpELLQSPVIQQLRAQLAE-----------LEAELAELSARYTPNHPDVIALRAQIAA 302

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  483 LESQLRQAkteLEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDnAELNNQNF-YLSKQLDEAS 561
Cdd:COG3206    303 LRAQLQQE---AQRILASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRRLERE-VEVARELYeSLLQRLEEAR 378
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
383-787 8.28e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 63.63  E-value: 8.28e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  383 RNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISH--QDHSDKSRLLELETRLREVSlEHEEQKLELKRQLT 460
Cdd:COG4717     71 KELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEElrEELEKLEKLLQLLPLYQELE-ALEAELAELPERLE 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  461 ELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvITDLEEQLNQLT 540
Cdd:COG4717    150 ELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEE---LEEAQEELEELE 226

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  541 EDNAELNNQ--NFYLSKQLDEA-------------SGAND----------EIVQLRSEVDHLRREITEREMQLTSQKQAQ 595
Cdd:COG4717    227 EELEQLENEleAAALEERLKEArlllliaaallalLGLGGsllsliltiaGVLFLVLGLLALLFLLLAREKASLGKEAEE 306

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  596 LSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVL-----GDEKSQFECRVRELQRMLDTEK-QSRAR 669
Cdd:COG4717    307 LQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLreaeeLEEELQLEELEQEIAALLAEAGvEDEEE 386

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  670 ADQRITESRQVVELavkehKAEILALQQALKEQKLKAESLSDKLNDlekkhAMLEMNARSLQQKLETERELKQRLLEEQA 749
Cdd:COG4717    387 LRAALEQAEEYQEL-----KEELEELEEQLEELLGELEELLEALDE-----EELEEELEELEEELEELEEELEELREELA 456

                          410       420       430
                   ....*....|....*....|....*....|....*...
gi 1039770402  750 KLQQQMDLQKNhifrlTQGLQEALDRADLLKTERSDLE 787
Cdd:COG4717    457 ELEAELEQLEE-----DGELAELLQELEELKAELRELA 489
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1-603 8.39e-10

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 63.84  E-value: 8.39e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402    1 MLLGEEAMMEQEMTRLHRRVSEV--EAVLSQKEVELKASETQRSLLEQDLATYITEcsSLKRSLEQARMEVSQEDDKALQ 78
Cdd:pfam02463  385 RLSSAAKLKEEELELKSEEEKEAqlLLELARQLEDLLKEEKKEELEILEEEEESIE--LKQGKLTEEKEELEKQELKLLK 462

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   79 LLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQlEEDLVSARRRSDLYESELRESR------------------LAAEEF 140
Cdd:pfam02463  463 DELELKKSEDLLKETQLVKLQEQLELLLSRQKL-EERSQKESKARSGLKVLLALIKdgvggriisahgrlgdlgVAVENY 541

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  141 KRKA-NECQHKLMKAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEK--- 216
Cdd:pfam02463  542 KVAIsTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDdkr 621

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  217 -LHNREDSSEGIKKKLVEAE-----ERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSA 290
Cdd:pfam02463  622 aKVVEGILKDTELTKLKESAkakesGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEI 701

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  291 QHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEA 370
Cdd:pfam02463  702 KKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEERE 781

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  371 NKLAANSSLFTQRNMKAQEEMISELRQQKFY-LETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHE 449
Cdd:pfam02463  782 KTEKLKVEEEKEEKLKAQEEELRALEEELKEeAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEE 861

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  450 EQKLELKRQLTELQLSLQERESQLTALQAArAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVI 529
Cdd:pfam02463  862 EITKEELLQELLLKEEELEEQKLKDELESK-EEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEEL 940

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039770402  530 TDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQT 603
Cdd:pfam02463  941 LLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEE 1014
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 75-883 9.74e-10

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 63.91  E-value: 9.74e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   75 KALQLLHDIRE-QSRKLQEIKE-----QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRlaaeEFKRKANECQ 148
Cdd:TIGR00606  186 KALETLRQVRQtQGQKVQEHQMelkylKQYKEKACEIRDQITSKEAQLESSREIVKSYENELDPLK----NRLKEIEHNL 261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  149 HKLMKAKDqgkpevgEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERA--------ERELEKLhNR 220
Cdd:TIGR00606  262 SKIMKLDN-------EIKALKSRKKQMEKDNSELELKMEKVFQGTDEQLNDLYHNHQRTVREkerelvdcQRELEKL-NK 333

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  221 EDSSEGIKKKLVEAEERRHSLenKVKRLETMERRENRLKDDIQTKSE--------------------QIQQMADK----- 275
Cdd:TIGR00606  334 ERRLLNQEKTELLVEQGRLQL--QADRHQEHIRARDSLIQSLATRLEldgfergpfserqiknfhtlVIERQEDEaktaa 411

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  276 --ILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLD---NQIKKDLADKESLENMMQRHEEEAHEKGKILSE-QKAM 349
Cdd:TIGR00606  412 qlCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEkkqEELKFVIKELQQLEGSSDRILELDQELRKAERElSKAE 491

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  350 INA------------------MDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLeA 411
Cdd:TIGR00606  492 KNSltetlkkevkslqnekadLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLGYF-P 570

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  412 QNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRqLTELQLSLQERESQLTALQAARAALES---QLR 488
Cdd:TIGR00606  571 NKKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELES-KEEQLSSYEDKLFDVCGSQDEESDLERlkeEIE 649

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  489 QAKTELEETTAEAEEEIQALTAHRDE-------IQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEAS 561
Cdd:TIGR00606  650 KSSKQRAMLAGATAVYSQFITQLTDEnqsccpvCQRVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEML 729

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  562 G-----------ANDEIVQLRSEVDHLRREITEREMQLTSQ-KQAQLSAPDLQTMEALKTTCTMLEEQVLDLE------- 622
Cdd:TIGR00606  730 GlapgrqsiidlKEKEIPELRNKLQKVNRDIQRLKNDIEEQeTLLGTIMPEEESAKVCLTDVTIMERFQMELKdverkia 809

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  623 ----------------ALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRM------LDTEK--------QSRARADQ 672
Cdd:TIGR00606  810 qqaaklqgsdldrtvqQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLksktneLKSEKlqigtnlqRRQQFEEQ 889

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  673 RITESRQVVEL--AVKEHKAEILALQQALKEQKLKAESL-----------SDKLNDLEKKHAMLEMNARSLQQKLE--TE 737
Cdd:TIGR00606  890 LVELSTEVQSLirEIKDAKEQDSPLETFLEKDQQEKEELissketsnkkaQDKVNDIKEKVKNIHGYMKDIENKIQdgKD 969

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  738 RELKQRlLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQL----------ENIQVLYSHEKVKMEGT 807
Cdd:TIGR00606  970 DYLKQK-ETELNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQERWLQDNLtlrkrenelkEVEEELKQHLKEMGQMQ 1048

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770402  808 ISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEdpalptqvplqYNELKLALEKE--KARCAELEEALQKTRIELRSARE 883
Cdd:TIGR00606 1049 VLQMKQEHQKLEENIDLIKRNHVLALGRQKG-----------YEKEIKHFKKElrEPQFRDAEEKYREMMIVMRTTEL 1115
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
197-768 1.37e-09

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 62.86  E-value: 1.37e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  197 TELLQNIRQA-KERAERELEKLHNREDssegikKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADK 275
Cdd:COG4717     37 STLLAFIRAMlLERLEKEADELFKPQG------RKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAE 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  276 ILELEEKHREAQVSAQHLEVHLKQKEqhyeekikvldnqikkdlaDKESLENMMQRHEEeahekgkiLSEQKAMINAMDS 355
Cdd:COG4717    111 LEELREELEKLEKLLQLLPLYQELEA-------------------LEAELAELPERLEE--------LEERLEELRELEE 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  356 KIRSLEQRIVELSEA-NKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIS--HQDHSDKS 432
Cdd:COG4717    164 ELEELEAELAELQEElEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLEneLEAAALEE 243

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  433 RLLELETRLREVSLEHEeqklelkrqLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHR 512
Cdd:COG4717    244 RLKEARLLLLIAAALLA---------LLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALE 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  513 DEIQRKFDALRNSCTVITDLEEqlnqltednaelnnqnfylsKQLDEASGANDEIVQLRSEVDHLRREIteREMQLTSQK 592
Cdd:COG4717    315 ELEEEELEELLAALGLPPDLSP--------------------EELLELLDRIEELQELLREAEELEEEL--QLEELEQEI 372

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  593 QAQLSAPDLQTMEALKTTCTMLEEQV---LDLEALNDELLEKERQWEAWRSVLGDEksqfecrvrELQRMLDTEKQSRAR 669
Cdd:COG4717    373 AALLAEAGVEDEEELRAALEQAEEYQelkEELEELEEQLEELLGELEELLEALDEE---------ELEEELEELEEELEE 443

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  670 ADQRITESRQvvELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQA 749
Cdd:COG4717    444 LEEELEELRE--ELAELEAELEQLEEDGELAELLQELEELKAELRELAEEWAALKLALELLEEAREEYREERLPPVLERA 521

                          570       580
                   ....*....|....*....|
gi 1039770402  750 klqqqmdlqkNHIF-RLTQG 768
Cdd:COG4717    522 ----------SEYFsRLTDG 531
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
72-679 1.39e-09

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 63.01  E-value: 1.39e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   72 EDDKALQLLHDIreQSRK----LQE-IKEQ-----EYQAQVEEMRLMMNQL---EEDLVSARRRSDLyeseLRESRLAAE 138
Cdd:COG4913    189 GSEKALRLLHKT--QSFKpigdLDDfVREYmleepDTFEAADALVEHFDDLeraHEALEDAREQIEL----LEPIRELAE 262

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  139 EFKRKANECQHkLMKAKDQGKPEvgeysklekinaEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLH 218
Cdd:COG4913    263 RYAAARERLAE-LEYLRAALRLW------------FAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDELE 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  219 NREDSSEGIKKKLVEAEerrhsLENKVKRLETMERRENRLKDDIQT--------------KSEQIQQMADKILELEEKHR 284
Cdd:COG4913    330 AQIRGNGGDRLEQLERE-----IERLERELEERERRRARLEALLAAlglplpasaeefaaLRAEAAALLEALEEELEALE 404

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  285 EAQVSAQHLEVHLKQKEQHYEEKIKVLDN----------QIKKDLADKESLE--------NMMQRHEEEAHEKGKI---- 342
Cdd:COG4913    405 EALAEAEAALRDLRRELRELEAEIASLERrksniparllALRDALAEALGLDeaelpfvgELIEVRPEEERWRGAIervl 484

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  343 -------------LSEQKAMINAMDSKIR------------SLEQRIVELSEANKLAANSSLFTQRnmkAQEEM------ 391
Cdd:COG4913    485 ggfaltllvppehYAAALRWVNRLHLRGRlvyervrtglpdPERPRLDPDSLAGKLDFKPHPFRAW---LEAELgrrfdy 561

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  392 -----ISELRQQKFYLeTQAGKLeAQNRKLEEqlekisHQDHSdksrlleletRLREVSL---EHEEQKLELKRQLTELQ 463
Cdd:COG4913    562 vcvdsPEELRRHPRAI-TRAGQV-KGNGTRHE------KDDRR----------RIRSRYVlgfDNRAKLAALEAELAELE 623

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  464 LSLQERESQLTALQAARAALESQLRQakteleettaeaeeeIQALTAHRDEIQRKFDALRNsctvITDLEEQLNQLTEDN 543
Cdd:COG4913    624 EELAEAEERLEALEAELDALQERREA---------------LQRLAEYSWDEIDVASAERE----IAELEAELERLDASS 684

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  544 AELNNqnfyLSKQLDEasgANDEIVQLRSEVDHLRREITEREMQLTS-QKQAQLSAPDLQTMEALKTtctmlEEQVLDLE 622
Cdd:COG4913    685 DDLAA----LEEQLEE---LEAELEELEEELDELKGEIGRLEKELEQaEEELDELQDRLEAAEDLAR-----LELRALLE 752

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039770402  623 ALNDELLEKERQWEAwrsvlgdeksqfecrVRELQRMLDTEKQSRARADQRITESRQ 679
Cdd:COG4913    753 ERFAAALGDAVEREL---------------RENLEERIDALRARLNRAEEELERAMR 794
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
334-792 1.81e-09

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 63.01  E-value: 1.81e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  334 EEAHEKGKILSEQKAM---INAMDSKIRSLEQRIVELSEAnkLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLE 410
Cdd:COG4913    238 ERAHEALEDAREQIELlepIRELAERYAAARERLAELEYL--RAALRLWFAQRRLELLEAELEELRAELARLEAELERLE 315

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  411 AQNRKLEEQLEKISHQ-DHSDKSRLLELETRLREVSLEHEEQK---LELKRQLTELQLSLQERESQLTALQAARAALESQ 486
Cdd:COG4913    316 ARLDALREELDELEAQiRGNGGDRLEQLEREIERLERELEERErrrARLEALLAALGLPLPASAEEFAALRAEAAALLEA 395

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  487 LRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVI--------TDLEEQLN-------------QLTEDNAE 545
Cdd:COG4913    396 LEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIparllalrDALAEALGldeaelpfvgeliEVRPEEER 475

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  546 --------LNNQNFYL---SKQLDEASGANDEIvqlrsevdHLRREITEREMQLTSQKQAQLSAPD---LQTMEALKTTC 611
Cdd:COG4913    476 wrgaiervLGGFALTLlvpPEHYAAALRWVNRL--------HLRGRLVYERVRTGLPDPERPRLDPdslAGKLDFKPHPF 547

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  612 TM-LEEQ---------VLDLEALNDE---------------LLEKERQWEAWRS-VLG----DEKSQFECRVRELQRMLD 661
Cdd:COG4913    548 RAwLEAElgrrfdyvcVDSPEELRRHpraitragqvkgngtRHEKDDRRRIRSRyVLGfdnrAKLAALEAELAELEEELA 627

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  662 T--EKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEqklkAESLSDKLNDLEKKHAMLemnaRSLQQKLETERE 739
Cdd:COG4913    628 EaeERLEALEAELDALQERREALQRLAEYSWDEIDVASAERE----IAELEAELERLDASSDDL----AALEEQLEELEA 699

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039770402  740 LKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRAD-LLKTERSDLEYQLEN 792
Cdd:COG4913    700 ELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEaAEDLARLELRALLEE 753
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 33-487 2.07e-09

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 62.43  E-value: 2.07e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   33 ELKASETQRSLLEQDLATYITECSSLKRSlEQARMEVSQEDDKALQLlhDIREQSRKLQEIKEQEYQAQVEemrlmmnqL 112
Cdd:pfam05483  339 ELNKAKAAHSFVVTEFEATTCSLEELLRT-EQQRLEKNEDQLKIITM--ELQKKSSELEEMTKFKNNKEVE--------L 407

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  113 EE-DLVSARRRSDLYESELRESrlAAEEFKRKANECQHkLMKAKDQGKPEVGEYSKLEKINAEQQLK-IQELQEKLEKAV 190
Cdd:pfam05483  408 EElKKILAEDEKLLDEKKQFEK--IAEELKGKEQELIF-LLQAREKEIHDLEIQLTAIKTSEEHYLKeVEDLKTELEKEK 484

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  191 KASTEATE-----LLQNIRQAKERAERELEKLHNREDSSEGIKKKlveaeerrhslENKVKRLETMERRENRLKDDIQTK 265
Cdd:pfam05483  485 LKNIELTAhcdklLLENKELTQEASDMTLELKKHQEDIINCKKQE-----------ERMLKQIENLEEKEMNLRDELESV 553

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  266 SEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIkvldNQIKKDLADKEslENMMQRHEEEAHEKGKILSE 345
Cdd:pfam05483  554 REEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKC----NNLKKQIENKN--KNIEELHQENKALKKKGSAE 627

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  346 QKAMiNAMDSKIRSLEQrivelseanKLAANSSLFTQRNMKAQEEM-ISELRQQKFYLETQAGKLEAQNR-KLEEQLEKI 423
Cdd:pfam05483  628 NKQL-NAYEIKVNKLEL---------ELASAKQKFEEIIDNYQKEIeDKKISEEKLLEEVEKAKAIADEAvKLQKEIDKR 697

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039770402  424 SHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQER-ESQLTALQAARAALESQL 487
Cdd:pfam05483  698 CQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKNKEQEQSSAKAAlEIELSNIKAELLSLKKQL 762
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 5-480 2.10e-09

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 62.53  E-value: 2.10e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402    5 EEAMMEQEMTRLHRRVSEVEAVLSQKEVE---LKASETQRSLLEQD------LATYI----TECSSLKRSLEQARMEVsq 71
Cdd:pfam10174  179 EDWERTRRIAEAEMQLGHLEVLLDQKEKEnihLREELHRRNQLQPDpaktkaLQTVIemkdTKISSLERNIRDLEDEV-- 256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   72 EDDKALQLLH-DIREQSRKLQEI---------------------KEQEYQAQVEEMRLMMNQ----------LEEDLVSA 119
Cdd:pfam10174  257 QMLKTNGLLHtEDREEEIKQMEVykshskfmknkidqlkqelskKESELLALQTKLETLTNQnsdckqhievLKESLTAK 336

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  120 RRRSDLYESELRESRLAAEEFKRKANECQHKLMKAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATEL 199
Cdd:pfam10174  337 EQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKSTLAGEIRDLKDMLDVKERKINVLQKKIENLQEQLRDKDKQ 416

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  200 LQNIRqakeRAERELEKLHNREDSSEGI-------KKKLVEAEERRHSLENKVKR--LETMERRENRLKDDIQTKSEQIQ 270
Cdd:pfam10174  417 LAGLK----ERVKSLQTDSSNTDTALTTleealseKERIIERLKEQREREDRERLeeLESLKKENKDLKEKVSALQPELT 492

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  271 QMADKILELEEKHREAQVSAQHLEVHLKQKE----QHYEEKIKvLDNQIKK------------DLADK-ESLENMMQRHE 333
Cdd:pfam10174  493 EKESSLIDLKEHASSLASSGLKKDSKLKSLEiaveQKKEECSK-LENQLKKahnaeeavrtnpEINDRiRLLEQEVARYK 571

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  334 EEAHEKG-------KILSEQKAMINAMDSKIRSLEQRIV-ELSEANKLAANSSLFTQRNMKAQEEMISELRQqkfylETQ 405
Cdd:pfam10174  572 EESGKAQaeverllGILREVENEKNDKDKKIAELESLTLrQMKEQNKKVANIKHGQQEMKKKGAQLLEEARR-----RED 646

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770402  406 AGKLEAQNRKLEEQLEkishqdhsdksrlleletrlrevSLEHEEQKLE-LKRQLTELQLSLQERESQLTALQAAR 480
Cdd:pfam10174  647 NLADNSQQLQLEELMG-----------------------ALEKTRQELDaTKARLSSTQQSLAEKDGHLTNLRAER 699
ROM1 COG5422
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction ...
 1208-1459 2.11e-09

RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms];


Pssm-ID: 227709 [Multi-domain]  Cd Length: 1175  Bit Score: 62.60  E-value: 2.11e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402 1208 SDQVVLVGTEEGLYALNVLKNS--------LTHIPGIGavfQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLp 1279
Cdd:COG5422    868 SGRKLLTGTNKGLYISNRKDNVnrfnkpidLLQEPNIS---QIIVIEEYKLMLLLSDKKLYSCPLDVIDASTEENVKKS- 943

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402 1280 aqpDVSPNIFEAVK-----GCHLFAAGKiENSLCICAAMPSKVVILRYNDN------LSKYCIRKEIETSEPCScIHFTN 1348
Cdd:COG5422    944 ---RIVNGHVSFFKqgfcnGKRLVCAVK-SSSLSATLAVIEAPLALKKNKSgnlkkaLTIELSTELYVPSEPLS-VHFLK 1018

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402 1349 YSILIGTNKFYEI-DMKQYTLDEFLDKNDHSlaPAVFASSSNSFPVSIVQANSagqreEYLLCFHEFGVFVDSYGRRSRT 1427
Cdd:COG5422   1019 NKLCIGCKKGFEIvSLENLRTESLLNPADTS--PLFFEKKENTKPIAIFRVSG-----EFLLCYSEFAFFVNDQGWRKRT 1091

                          250       260       270
                   ....*....|....*....|....*....|...
gi 1039770402 1428 DDL-KWSRLPLAFAYREPYlfVTHFNSlEVIEI 1459
Cdd:COG5422   1092 SWIfHWEGEPQEFALSYPY--ILAFEP-NFIEI 1121
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 10-789 3.61e-09

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 61.99  E-value: 3.61e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   10 EQEMTRLHRRVSEVEA---VLSQKEVELKASETQRSLLEQdlatyITECSSLKRSLEQARMEVSQEDDkALQLLHDIREQ 86
Cdd:TIGR00606  318 ERELVDCQRELEKLNKerrLLNQEKTELLVEQGRLQLQAD-----RHQEHIRARDSLIQSLATRLELD-GFERGPFSERQ 391

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   87 SRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKAKDQGKPEVGEYS 166
Cdd:TIGR00606  392 IKNFHTLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSD 471

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  167 KLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQA----KERAERELEKLHNREDSS----EGIKKKLVEAEER- 237
Cdd:TIGR00606  472 RILELDQELRKAERELSKAEKNSLTETLKKEVKSLQNEKAdldrKLRKLDQEMEQLNHHTTTrtqmEMLTKDKMDKDEQi 551

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  238 -----RHSLEnkVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQH---YEEKIK 309
Cdd:TIGR00606  552 rkiksRHSDE--LTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQlssYEDKLF 629

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  310 vldnqikkDLADKESLENMMQRHEEEAHEKGKilseQKAMINAmdsKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQE 389
Cdd:TIGR00606  630 --------DVCGSQDEESDLERLKEEIEKSSK----QRAMLAG---ATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQ 694

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  390 EMISELRQQKFYLETQAGKLEAQNRKLEEQLEKI--------SHQDHSDKsRLLELETRLREVSLEHEEQKLELKRQLTE 461
Cdd:TIGR00606  695 EFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMlglapgrqSIIDLKEK-EIPELRNKLQKVNRDIQRLKNDIEEQETL 773

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  462 LQLSLQERES------QLTALQAARAALESQLRQ-AKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSC----TVIT 530
Cdd:TIGR00606  774 LGTIMPEEESakvcltDVTIMERFQMELKDVERKiAQQAAKLQGSDLDRTVQQVNQEKQEKQHELDTVVSKIelnrKLIQ 853

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  531 DLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREIteremqltSQKQAQLSaPDLQTMEalktt 610
Cdd:TIGR00606  854 DQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREI--------KDAKEQDS-PLETFLE----- 919

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  611 ctmleeqvlDLEALNDELLEKERQweawrsvlgdEKSQFECRVRELQRMLDTEKQSRARADQRITESRqvvELAVKEHKA 690
Cdd:TIGR00606  920 ---------KDQQEKEELISSKET----------SNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGK---DDYLKQKET 977

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  691 EILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKL----------ETERELKQRLLE-----------EQA 749
Cdd:TIGR00606  978 ELNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQERWLQDNLtlrkrenelkEVEEELKQHLKEmgqmqvlqmkqEHQ 1057

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|
gi 1039770402  750 KLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQ 789
Cdd:TIGR00606 1058 KLEENIDLIKRNHVLALGRQKGYEKEIKHFKKELREPQFR 1097
PTZ00121 PTZ00121
MAEBL; Provisional
 159-892 4.10e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 61.70  E-value: 4.10e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  159 KPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAE--RELEKLHNREDSSEGIKKKLVEaEE 236
Cdd:PTZ00121  1073 KPSYKDFDFDAKEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEdaRKAEEARKAEDARKAEEARKAE-DA 1151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  237 RRHSLENKV---KRLETMERRENRLKDDIQTKSEQIQQMADkiLELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVldN 313
Cdd:PTZ00121  1152 KRVEIARKAedaRKAEEARKAEDAKKAEAARKAEEVRKAEE--LRKAEDARKAEAARKAEEERKAEEARKAEDAKKA--E 1227

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  314 QIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMdskirslEQRIVELSEANKlaansslfTQRNMKAQE-EMI 392
Cdd:PTZ00121  1228 AVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFAR-------RQAAIKAEEARK--------ADELKKAEEkKKA 1292

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  393 SELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDhsdKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESq 472
Cdd:PTZ00121  1293 DEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEA---KKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEA- 1368

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  473 ltalqaarAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEqlnqlTEDNAELNNQNFY 552
Cdd:PTZ00121  1369 --------AEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADE-----AKKKAEEKKKADE 1435

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  553 LSKQLDEASGANDeiVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTCtmlEEQVLDLEALNDELLEKE 632
Cdd:PTZ00121  1436 AKKKAEEAKKADE--AKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKA---EEAKKKADEAKKAAEAKK 1510

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  633 RQWEAWRSvlgDEKSQFEcRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQAlKEQKLKAESLSDK 712
Cdd:PTZ00121  1511 KADEAKKA---EEAKKAD-EAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKA-EEDKNMALRKAEE 1585

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  713 LNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLEN 792
Cdd:PTZ00121  1586 AKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAE 1665

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  793 IQVLYSHEKVKMEgtisqqtklidflQAKMDQPAKKKKGLFSRRKEDPALPTQvplqynELKLALEKEKARCAEL--EEA 870
Cdd:PTZ00121  1666 EAKKAEEDKKKAE-------------EAKKAEEDEKKAAEALKKEAEEAKKAE------ELKKKEAEEKKKAEELkkAEE 1726

                          730       740
                   ....*....|....*....|..
gi 1039770402  871 LQKTRIELRSAREEAAHRKATD 892
Cdd:PTZ00121  1727 ENKIKAEEAKKEAEEDKKKAEE 1748
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 5-463 4.41e-09

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 61.60  E-value: 4.41e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402    5 EEAMMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDL------ATYITECSSLKRSLEQARMEVSQEDDKAL- 77
Cdd:TIGR00606  585 EINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLfdvcgsQDEESDLERLKEEIEKSSKQRAMLAGATAv 664

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   78 --QLLHDIREQSRKLQEIKEQEYQAQvEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKAnECQHKLMKAK 155
Cdd:TIGR00606  665 ysQFITQLTDENQSCCPVCQRVFQTE-AELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLA-PGRQSIIDLK 742

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  156 DQGKPEVGEysKLEKINAEQQLKIQEL--QEKLEKAVKASTEATE-------LLQNIRQAKERAERELEKLHNREDSSEG 226
Cdd:TIGR00606  743 EKEIPELRN--KLQKVNRDIQRLKNDIeeQETLLGTIMPEEESAKvcltdvtIMERFQMELKDVERKIAQQAAKLQGSDL 820

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  227 IKKklveAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKH---REAQVSAQHLEVHLKQKEQH 303
Cdd:TIGR00606  821 DRT----VQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKlqiGTNLQRRQQFEEQLVELSTE 896

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  304 YEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKI-------RSLEQRIVE---------L 367
Cdd:TIGR00606  897 VQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVknihgymKDIENKIQDgkddylkqkE 976

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  368 SEANKLAANSSLFTQRNMKAQEEM------ISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLE----- 436
Cdd:TIGR00606  977 TELNTVNAQLEECEKHQEKINEDMrlmrqdIDTQKIQERWLQDNLTLRKRENELKEVEEELKQHLKEMGQMQVLQmkqeh 1056

                          490       500       510
                   ....*....|....*....|....*....|....*....
gi 1039770402  437 --LETRLREVSLEH----------EEQKLELKRQLTELQ 463
Cdd:TIGR00606 1057 qkLEENIDLIKRNHvlalgrqkgyEKEIKHFKKELREPQ 1095
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 2-338 7.47e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 60.85  E-value: 7.47e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402    2 LLGEEAMMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYI-------TECSSLKRSLEQARMEVSQEDD 74
Cdd:TIGR02169  686 LKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKerleeleEDLSSLEQEIENVKSELKELEA 765

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   75 KALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKA 154
Cdd:TIGR02169  766 RIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDL 845

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  155 KDQGKpevgeysKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEgikkklVEA 234
Cdd:TIGR02169  846 KEQIK-------SIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELE------AQI 912

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  235 EERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADkILELEEKHREAQVSAQHLE-VHLKQKEQHYEEKIKVLDN 313
Cdd:TIGR02169  913 EKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEELS-LEDVQAELQRVEEEIRALEpVNMLAIQEYEEVLKRLDEL 991

                          330       340
                   ....*....|....*....|....*..
gi 1039770402  314 QIKKD--LADKESLENMMQRHEEEAHE 338
Cdd:TIGR02169  992 KEKRAklEEERKAILERIEEYEKKKRE 1018
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 137-881 8.41e-09

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 60.74  E-value: 8.41e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  137 AEEFKRKANECQHKLMKAKDQgkpEVGEYSKLEKINAEQQL---------KIQELQEKLEKAVKASTEATELLQNIRQAK 207
Cdd:COG3096    270 AADYMRHANERRELSERALEL---RRELFGARRQLAEEQYRlvemareleELSARESDLEQDYQAASDHLNLVQTALRQQ 346

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  208 ERAER------EL-EKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQM------AD 274
Cdd:COG3096    347 EKIERyqedleELtERLEEQEEVVEEAAEQLAEAEARLEAAEEEVDSLKSQLADYQQALDVQQTRAIQYQQAvqalekAR 426

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  275 KILELEEKHREAqvSAQHLEVHLKQKEQHYEEkikVLDNQIKKDLAD--KESLENMMQRHE--------EEAHEKGKIL- 343
Cdd:COG3096    427 ALCGLPDLTPEN--AEDYLAAFRAKEQQATEE---VLELEQKLSVADaaRRQFEKAYELVCkiageverSQAWQTARELl 501

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  344 ---SEQKAMI---NAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQ---EEMISELRQQKFYLETQAGKLEAQNR 414
Cdd:COG3096    502 rryRSQQALAqrlQQLRAQLAELEQRLRQQQNAERLLEEFCQRIGQQLDAAeelEELLAELEAQLEELEEQAAEAVEQRS 581

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  415 KLEEQLEKISHQDHSDKSR---LLELETRLREVSlEHEEQKLELKRQLTELQLSLQERESQLTA----LQAARAALESQL 487
Cdd:COG3096    582 ELRQQLEQLRARIKELAARapaWLAAQDALERLR-EQSGEALADSQEVTAAMQQLLEREREATVerdeLAARKQALESQI 660

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  488 RQAKTELEETTAEAEEEIQALTAH-----RDEIQRK----FDAL----RNScTVITDLE---EQLNQLT---------ED 542
Cdd:COG3096    661 ERLSQPGGAEDPRLLALAERLGGVllseiYDDVTLEdapyFSALygpaRHA-IVVPDLSavkEQLAGLEdcpedlyliEG 739

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  543 NAELNNQNFYLSKQLDEASGANDEIVQLR----SEVDHLRR-------EITEREMQLTSQKQAQLSApDLQTMEALKTTC 611
Cdd:COG3096    740 DPDSFDDSVFDAEELEDAVVVKLSDRQWRysrfPEVPLFGRaarekrlEELRAERDELAEQYAKASF-DVQKLQRLHQAF 818

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  612 TMLEEQVLDLEALNDEllekerqwEAWRSVLGDEKSQFEcrvRELQRMLDTEKQSRARADQ---RITESRQVVELAVKEH 688
Cdd:COG3096    819 SQFVGGHLAVAFAPDP--------EAELAALRQRRSELE---RELAQHRAQEQQLRQQLDQlkeQLQLLNKLLPQANLLA 887

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  689 KAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEeqakLQQQMDLQKNHIFRLTQG 768
Cdd:COG3096    888 DETLADRLEELREELDAAQEAQAFIQQHGKALAQLEPLVAVLQSDPEQFEQLQADYLQ----AKEQQRRLKQQIFALSEV 963

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  769 LQ--EAL---DRADLLkTERSD----LEYQLENIQVLYSHEKVKMEGtisQQTKLIDFLQAKMDQPAK---KKKGLFSRR 836
Cdd:COG3096    964 VQrrPHFsyeDAVGLL-GENSDlnekLRARLEQAEEARREAREQLRQ---AQAQYSQYNQVLASLKSSrdaKQQTLQELE 1039

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1039770402  837 KEDPALPTQVP--------LQYNELKLALEKEKARCAELEEALQKTRIELRSA 881
Cdd:COG3096   1040 QELEELGVQADaeaeerarIRRDELHEELSQNRSRRSQLEKQLTRCEAEMDSL 1092
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 5-472 9.21e-09

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 60.52  E-value: 9.21e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402    5 EEAMMEQEMTRLHRRVSEVEAVLSQKEVELKASETQ-RSLLEQDLATYITeCSSLKRSLEQARMEV-----------SQE 72
Cdd:pfam15921  364 ERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQnKRLWDRDTGNSIT-IDHLRRELDDRNMEVqrleallkamkSEC 442

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   73 DDKALQLLHDIREQSRKLQEIkeQEYQAQVEEMRLMMNQLEEDLV--------SARRRSDLYESeLRESRLAAE------ 138
Cdd:pfam15921  443 QGQMERQMAAIQGKNESLEKV--SSLTAQLESTKEMLRKVVEELTakkmtlesSERTVSDLTAS-LQEKERAIEatnaei 519

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  139 -----EFKRKANECQHkLMKAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVK-----ASTEATELLQNIRQAKE 208
Cdd:pfam15921  520 tklrsRVDLKLQELQH-LKNEGDHLRNVQTECEALKLQMAEKDKVIEILRQQIENMTQlvgqhGRTAGAMQVEKAQLEKE 598

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  209 RAERELEK-----LHNREDSsegikkKLVEAEERRHSLE-NKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEK 282
Cdd:pfam15921  599 INDRRLELqefkiLKDKKDA------KIRELEARVSDLElEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRNELNSL 672

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  283 HREAQVsaqhLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQ 362
Cdd:pfam15921  673 SEDYEV----LKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQS 748

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  363 RIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEqlekishqdhsdksRLLELETRLR 442
Cdd:pfam15921  749 KIQFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKE--------------KVANMEVALD 814

                          490       500       510
                   ....*....|....*....|....*....|....*
gi 1039770402  443 EVSLEHEEQKLELKRQLTE-----LQLSLQERESQ 472
Cdd:pfam15921  815 KASLQFAECQDIIQRQEQEsvrlkLQHTLDVKELQ 849
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
416-885 1.15e-08

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 59.78  E-value: 1.15e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  416 LEEQLEKISHQDHSDKSRLLELE-TRLREVSLEHEEQKlELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTEL 494
Cdd:COG4717     47 LLERLEKEADELFKPQGRKPELNlKELKELEEELKEAE-EKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLL 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  495 EETTAEAEeeIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQ------------NFYLSKQLDEASG 562
Cdd:COG4717    126 QLLPLYQE--LEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEEleelleqlslatEEELQDLAEELEE 203

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  563 ANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTcTMLEEQVLDLEALNDELLEKERQWEAWRSVL 642
Cdd:COG4717    204 LQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLL-LLIAAALLALLGLGGSLLSLILTIAGVLFLV 282

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  643 GdeksqfecrvrelqRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKham 722
Cdd:COG4717    283 L--------------GLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDR--- 345

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  723 lemnARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHI-----FRltqGLQEALDRADLLKTERSDLEYQLENI---- 793
Cdd:COG4717    346 ----IEELQELLREAEELEEELQLEELEQEIAALLAEAGVedeeeLR---AALEQAEEYQELKEELEELEEQLEELlgel 418

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  794 -QVLYSHEKVKMEGTISQQTKLIDFLQAKMDQpAKKKKGLFSRRKEDpaLPTQVPLQynELKLALEKEKARCAELEE--- 869
Cdd:COG4717    419 eELLEALDEEELEEELEELEEELEELEEELEE-LREELAELEAELEQ--LEEDGELA--ELLQELEELKAELRELAEewa 493

                          490
                   ....*....|....*.
gi 1039770402  870 ALQKTRIELRSAREEA 885
Cdd:COG4717    494 ALKLALELLEEAREEY 509
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 10-238 1.58e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 58.62  E-value: 1.58e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   10 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRK 89
Cdd:COG4942     26 EAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEE 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   90 LQE-IKEQEYQAQVEEMRLMMNQleEDLVSARRRSDLYESELRESRLAAEEFKRKANEcqhkLMKAKDQgkpevgeyskL 168
Cdd:COG4942    106 LAElLRALYRLGRQPPLALLLSP--EDFLDAVRRLQYLKYLAPARREQAEELRADLAE----LAALRAE----------L 169

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  169 EKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERR 238
Cdd:COG4942    170 EAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAA 239
C1_KSR cd20812
protein kinase C conserved region 1 (C1 domain) found in the kinase suppressor of Ras (KSR) ...
 953-1004 2.12e-08

protein kinase C conserved region 1 (C1 domain) found in the kinase suppressor of Ras (KSR) family; KSR is a scaffold protein that functions downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. KSR proteins regulate the assembly and activation of the Raf/MEK/ERK module upon Ras activation at the membrane by direct association of its components. They are widely regarded as pseudokinases, but there is some debate in this designation as a few groups have reported detecting kinase catalytic activity for KSRs, specifically KSR1. Vertebrates contain two KSR proteins, KSR1 and KSR2. KSR proteins contain a SAM-like domain, a zinc finger cysteine-rich domain (C1), and a pseudokinase domain. This model describes the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410362  Cd Length: 48  Bit Score: 51.56  E-value: 2.12e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039770402  953 IPHRFNVGLNMRATkCAVCLDTVHFGRqasKCLECQVMCHPKCSTCLPATCG 1004
Cdd:cd20812      1 IKHRFSKKLFMRQT-CDYCHKQMFFGL---KCKDCKYKCHKKCAKKAPPSCG 48
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 200-795 2.18e-08

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 59.47  E-value: 2.18e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  200 LQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSlenkvkRLETMERRENRLKDDIQTKSEQIQQMADKiLEL 279
Cdd:pfam12128  236 IMKIRPEFTKLQQEFNTLESAELRLSHLHFGYKSDETLIAS------RQEERQETSAELNQLLRTLDDQWKEKRDE-LNG 308

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  280 EEKHREAQVSA--QHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKI 357
Cdd:pfam12128  309 ELSAADAAVAKdrSELEALEDQHGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQDVTAKYNRRRSKIKEQN 388

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  358 RSLEQRIVELSEANKLAANSSLFTQRNMKAQEEmiSELRQQkfyletqagkLEAQNRKLEEQLEKIshqdhsdKSRLLEL 437
Cdd:pfam12128  389 NRDIAGIKDKLAKIREARDRQLAVAEDDLQALE--SELREQ----------LEAGKLEFNEEEYRL-------KSRLGEL 449

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  438 ETRLREVSLEHEEqklelKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEettaeaeeeiQALTAHRDEIQR 517
Cdd:pfam12128  450 KLRLNQATATPEL-----LLQLENFDERIERAREEQEAANAEVERLQSELRQARKRRD----------QASEALRQASRR 514

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  518 kfdalrnsctvitdLEEQLNQLTEdnaelnnqnfyLSKQLDEASGANDEIvqLRSEV----DHLRREITEREMQLTSQKQ 593
Cdd:pfam12128  515 --------------LEERQSALDE-----------LELQLFPQAGTLLHF--LRKEApdweQSIGKVISPELLHRTDLDP 567

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  594 AQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEawrSVLGDEKS---QFECRVRELQRMLDTEKQSRARA 670
Cdd:pfam12128  568 EVWDGSVGGELNLYGVKLDLKRIDVPEWAASEEELRERLDKAE---EALQSAREkqaAAEEQLVQANGELEKASREETFA 644

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  671 DQRITESRQVVELAVKEHKAEILALQQALKEQKLKAE----SLSDKLNDLEKKH-AMLEMNARSLQ----QKLETERELK 741
Cdd:pfam12128  645 RTALKNARLDLRRLFDEKQSEKDKKNKALAERKDSANerlnSLEAQLKQLDKKHqAWLEEQKEQKReartEKQAYWQVVE 724

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770402  742 QRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRaDL------------LKTERSDLEYQLENIQV 795
Cdd:pfam12128  725 GALDAQLALLKAAIAARRSGAKAELKALETWYKR-DLaslgvdpdviakLKREIRTLERKIERIAV 789
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 45-791 2.69e-08

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 59.03  E-value: 2.69e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   45 EQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQeiKEQEYQAQVEEM--RLMMNQLEEDLVSARRR 122
Cdd:pfam01576    4 EEEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQ--AETELCAEAEEMraRLAARKQELEEILHELE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  123 SDLYESELRESRLAAEefkRKANECQHKLMKAKDQGKPEVGEYSKLEKINAEQQLK--------IQELQEKLEKAVKAST 194
Cdd:pfam01576   82 SRLEEEEERSQQLQNE---KKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKkleedillLEDQNSKLSKERKLLE 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  195 EATELLQNIRQAKERAERELEKLHNREDSSegikkkLVEAEERRHSLENKVKRLETMERRENRLKDDIQTK-SEQIQQMA 273
Cdd:pfam01576  159 ERISEFTSNLAEEEEKAKSLSKLKNKHEAM------ISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQiAELQAQIA 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  274 DKILELEEKHREAQVSAQHLEVHLKQKEQhYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMI--- 350
Cdd:pfam01576  233 ELRAQLAKKEEELQAALARLEEETAQKNN-ALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTELedt 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  351 ---NAMDSKIRS-LEQRIVEL-----SEANKLAANSSLFTQRNMKAQEEMISELRQQKFY---LETQAGKLEAQNRKLEE 418
Cdd:pfam01576  312 ldtTAAQQELRSkREQEVTELkkaleEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNkanLEKAKQALESENAELQA 391

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  419 QLEKISHQDHSDKSRLLELETRLREVSLEH---EEQKLELKRQLTELQL-------SLQERESQLTALQAARAALESQLR 488
Cdd:pfam01576  392 ELRTLQQAKQDSEHKRKKLEGQLQELQARLsesERQRAELAEKLSKLQSelesvssLLNEAEGKNIKLSKDVSSLESQLQ 471

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  489 QAKTELEETTAEAEEEIQALTAHRDEiqrkfdalRNSctvitdLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIV 568
Cdd:pfam01576  472 DTQELLQEETRQKLNLSTRLRQLEDE--------RNS------LQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDA 537

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  569 QLRSEVDHLRREItEREMQLTSQKQAQLSApdlqTMEALKTTCTMLEEQVLDL-------EALNDELLEKERQWE----- 636
Cdd:pfam01576  538 GTLEALEEGKKRL-QRELEALTQQLEEKAA----AYDKLEKTKNRLQQELDDLlvdldhqRQLVSNLEKKQKKFDqmlae 612

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  637 --AWRSVLGDEKSQFECRVRElqrmLDTEKQSRARADQRITESRQVVELAVKEHKAEI---------------------L 693
Cdd:pfam01576  613 ekAISARYAEERDRAEAEARE----KETRALSLARALEEALEAKEELERTNKQLRAEMedlvsskddvgknvhelerskR 688

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  694 ALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQ-------------------------QKLETER--ELKQRLLE 746
Cdd:pfam01576  689 ALEQQVEEMKTQLEELEDELQATEDAKLRLEVNMQALKaqferdlqardeqgeekrrqlvkqvRELEAELedERKQRAQA 768

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*..
gi 1039770402  747 EQAKLQQQMDLQ--KNHIFRLTQGLQEALDRADLLKTERSDLEYQLE 791
Cdd:pfam01576  769 VAAKKKLELDLKelEAQIDAANKGREEAVKQLKKLQAQMKDLQRELE 815
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 314-792 3.73e-08

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 58.21  E-value: 3.73e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  314 QIKKDLADKEsLENMMQRHEEE--AHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKlaansslftqrnmkaqeEM 391
Cdd:pfam05557   13 QLQNEKKQME-LEHKRARIELEkkASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALR-----------------EQ 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  392 ISELRQQKFYLETQAGKLEAQnrklEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLE---LKRQLTELQLSLQE 468
Cdd:pfam05557   75 AELNRLKKKYLEALNKKLNEK----ESQLADAREVISCLKNELSELRRQIQRAELELQSTNSEleeLQERLDLLKAKASE 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  469 RE---SQLTALQAARAALESQLR--QAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRnsctvitDLEEQLNQLTEDN 543
Cdd:pfam05557  151 AEqlrQNLEKQQSSLAEAEQRIKelEFEIQSQEQDSEIVKNSKSELARIPELEKELERLR-------EHNKHLNENIENK 223

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  544 AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREmqltsqKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEA 623
Cdd:pfam05557  224 LLLKEEVEDLKRKLEREEKYREEAATLELEKEKLEQELQSWV------KLAQDTGLNLRSPEDLSRRIEQLQQREIVLKE 297

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  624 LNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRI---TESRQVVELAVKEHKAEiLALQQALK 700
Cdd:pfam05557  298 ENSSLTSSARQLEKARRELEQELAQYLKKIEDLNKKLKRHKALVRRLQRRVlllTKERDGYRAILESYDKE-LTMSNYSP 376

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  701 EQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQ-----KNHIFRLTQGLQEALDR 775
Cdd:pfam05557  377 QLLERIEEAEDMTQKMQAHNEEMEAQLSVAEEELGGYKQQAQTLERELQALRQQESLAdpsysKEEVDSLRRKLETLELE 456

                          490
                   ....*....|....*..
gi 1039770402  776 ADLLKTERSDLEYQLEN 792
Cdd:pfam05557  457 RQRLREQKNELEMELER 473
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 416-872 3.81e-08

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 58.59  E-value: 3.81e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  416 LEEQLEKISHQdhsdksrLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAAR-------AALESQLR 488
Cdd:pfam15921   76 IERVLEEYSHQ-------VKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRrresqsqEDLRNQLQ 148

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  489 QAKTELEETTAEAEEEIQALTAHRDEIQRKF----DALRNSCTVITDLEEQ--------------------------LNQ 538
Cdd:pfam15921  149 NTVHELEAAKCLKEDMLEDSNTQIEQLRKMMlsheGVLQEIRSILVDFEEAsgkkiyehdsmstmhfrslgsaiskiLRE 228

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  539 LTEDNAELNNQNFYLSKQLD--EASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPdlQTMEALKTTCTMLEE 616
Cdd:pfam15921  229 LDTEISYLKGRIFPVEDQLEalKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSAR--SQANSIQSQLEIIQE 306

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  617 QVLDLEALN-DELLEKERQWEAWRSVLGDEKSQFECRVRELQRML---DTE-KQSRARADQRITES----RQVVELAVKE 687
Cdd:pfam15921  307 QARNQNSMYmRQLSDLESTVSQLRSELREAKRMYEDKIEELEKQLvlaNSElTEARTERDQFSQESgnldDQLQKLLADL 386

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  688 HKAEilaLQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQ-QKLETerELKQRLLEEQAKLQQQMdlqknhifRLT 766
Cdd:pfam15921  387 HKRE---KELSLEKEQNKRLWDRDTGNSITIDHLRRELDDRNMEvQRLEA--LLKAMKSECQGQMERQM--------AAI 453

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  767 QGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQakmdqpaKKKKGLFSRRKEDPALPTQV 846
Cdd:pfam15921  454 QGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQ-------EKERAIEATNAEITKLRSRV 526

                          490       500
                   ....*....|....*....|....*...
gi 1039770402  847 PLQYNELK-LALEKEKARCAELE-EALQ 872
Cdd:pfam15921  527 DLKLQELQhLKNEGDHLRNVQTEcEALK 554
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 175-423 3.88e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.47  E-value: 3.88e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  175 QQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLhnrEDSSEGIKKKLVEAEERRHSLENKVKRLetmERR 254
Cdd:COG4942     18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAAL---ERRIAALARRIRALEQELAALEAELAEL---EKE 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  255 ENRLKDDIQTKSEQIQQMAdkileleekhREAQVSAQHlevhlkqkeqhyeEKIKVLDNQikKDLADKESLENMMQRHEE 334
Cdd:COG4942     92 IAELRAELEAQKEELAELL----------RALYRLGRQ-------------PPLALLLSP--EDFLDAVRRLQYLKYLAP 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  335 EAHEKGKILSEQKAMINAmdsKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNR 414
Cdd:COG4942    147 ARREQAEELRADLAELAA---LRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAE 223


                   ....*....
gi 1039770402  415 KLEEQLEKI 423
Cdd:COG4942    224 ELEALIARL 232
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
15-584 5.70e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 58.00  E-value: 5.70e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   15 RLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATyitecssLKRSLEQARMEVSQEDDKAL-QLLHDIREQSRKLQEI 93
Cdd:COG4913    285 FAQRRLELLEAELEELRAELARLEAELERLEARLDA-------LREELDELEAQIRGNGGDRLeQLEREIERLERELEER 357

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   94 KE--QEYQAQVEEMRLMMNQLEEDLVSARRrsdlyesELRESRLAAEEFKRKANECQHKLMKAKDQGKpevgeySKLEKI 171
Cdd:COG4913    358 ERrrARLEALLAALGLPLPASAEEFAALRA-------EAAALLEALEEELEALEEALAEAEAALRDLR------RELREL 424

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  172 NAE-QQLK---------IQELQEKLEKAVKASTE----ATELLQnIRQAKERAERELEK-LHNR------EDSSEGIKKK 230
Cdd:COG4913    425 EAEiASLErrksniparLLALRDALAEALGLDEAelpfVGELIE-VRPEEERWRGAIERvLGGFaltllvPPEHYAAALR 503

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  231 LVEAEERRHSL-----ENKVKRLETMERRENRLKDDIQTKSEQIQQMADKIL-------------ELEEKHR----EAQV 288
Cdd:COG4913    504 WVNRLHLRGRLvyervRTGLPDPERPRLDPDSLAGKLDFKPHPFRAWLEAELgrrfdyvcvdspeELRRHPRaitrAGQV 583

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  289 SAQHlEVHLKQKeQHYEEKIKVL--DNQIKKDLAdkeslenmmqrhEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVE 366
Cdd:COG4913    584 KGNG-TRHEKDD-RRRIRSRYVLgfDNRAKLAAL------------EAELAELEEELAEAEERLEALEAELDALQERREA 649

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  367 LSEANKLAansslFTQRNMKAQEEMISELRQQKFYLETQAGKLEAqnrkLEEQLEKIshqdhsdKSRLLELETRLREVSL 446
Cdd:COG4913    650 LQRLAEYS-----WDEIDVASAEREIAELEAELERLDASSDDLAA----LEEQLEEL-------EAELEELEEELDELKG 713

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  447 EHEEQKLELKrQLTELQLSLQERESQLTALQAA--RAALESQLRQAKTELEETTAEAEEEiQALTAHRDEIQRKFDALRN 524
Cdd:COG4913    714 EIGRLEKELE-QAEEELDELQDRLEAAEDLARLelRALLEERFAAALGDAVERELRENLE-ERIDALRARLNRAEEELER 791

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770402  525 ------------SCTVITDLE------EQLNQLTEDNAELNNQNFylSKQLDEASgaNDEIVQLRSEVDHLRREITER 584
Cdd:COG4913    792 amrafnrewpaeTADLDADLEslpeylALLDRLEEDGLPEYEERF--KELLNENS--IEFVADLLSKLRRAIREIKER 865
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
195-735 7.16e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 57.62  E-value: 7.16e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  195 EATELLQNIRQAKE------RAERELEKLHNREDSSEGIkkklVEAEERRHSLENKVKRLETMERREnrlkdDIQTKSEQ 268
Cdd:COG4913    219 EEPDTFEAADALVEhfddleRAHEALEDAREQIELLEPI----RELAERYAAARERLAELEYLRAAL-----RLWFAQRR 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  269 IQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEkikvLDNQIKK-DLADKESLENMMQRHEEEAHEKGKILSEQK 347
Cdd:COG4913    290 LELLEAELEELRAELARLEAELERLEARLDALREELDE----LEAQIRGnGGDRLEQLEREIERLERELEERERRRARLE 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  348 AMINAMDSKIRSLEQRIVELSEANKLAANSSlftqrnmkaqEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQD 427
Cdd:COG4913    366 ALLAALGLPLPASAEEFAALRAEAAALLEAL----------EEELEALEEALAEAEAALRDLRRELRELEAEIASLERRK 435

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  428 HSDKSRLLELETRLREvSLEHEEQKL----ELkrqlteLQLSLQERESQLTA-----------------LQAARAALES- 485
Cdd:COG4913    436 SNIPARLLALRDALAE-ALGLDEAELpfvgEL------IEVRPEEERWRGAIervlggfaltllvppehYAAALRWVNRl 508

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  486 QLRQAKTELEETTAEAEEEIQALTAH-----------------RDEIQRKFD--------ALRNSCTVIT---------- 530
Cdd:COG4913    509 HLRGRLVYERVRTGLPDPERPRLDPDslagkldfkphpfrawlEAELGRRFDyvcvdspeELRRHPRAITragqvkgngt 588

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  531 -------DLEEQLNQLTEDNAELNNQnfyLSKQLDEAsgaNDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQT 603
Cdd:COG4913    589 rhekddrRRIRSRYVLGFDNRAKLAA---LEAELAEL---EEELAEAEERLEALEAELDALQERREALQRLAEYSWDEID 662

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  604 MEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSvlgdEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVEL 683
Cdd:COG4913    663 VASAEREIAELEAELERLDASSDDLAALEEQLEELEA----ELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEA 738

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039770402  684 AVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLE 735
Cdd:COG4913    739 AEDLARLELRALLEERFAAALGDAVERELRENLEERIDALRARLNRAEEELE 790
PH pfam00169
PH domain; PH stands for pleckstrin homology.
 1036-1155 7.52e-08

PH domain; PH stands for pleckstrin homology.


Pssm-ID: 459697 [Multi-domain]  Cd Length: 105  Bit Score: 52.18  E-value: 7.52e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402 1036 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVeefelclpdGDVSIHGAVgASELANTAKADVPY 1115
Cdd:pfam00169    1 VVKEGWLLKKGGGKKK--SWKKRYFVLFDGSLLYYKDDKSGKSKEPK---------GSISLSGCE-VVEVVASDSPKRKF 68

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1039770402 1116 ILKMESHPHTtcwPGRTLYLLAPSFPDKQRWVTALESVVA 1155
Cdd:pfam00169   69 CFELRTGERT---GKRTYLLQAESEEERKDWIKAIQSAIR 105
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 260-490 7.75e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 56.31  E-value: 7.75e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  260 DDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQhyeeKIKVLDNQIKKDLADKESLENMMQRHEEEAHEK 339
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALER----RIAALARRIRALEQELAALEAELAELEKEIAEL 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  340 GKILSEQKAMINAMdskIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQ 419
Cdd:COG4942     96 RAELEAQKEELAEL---LRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAE 172

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039770402  420 lekishqdhsdKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQA 490
Cdd:COG4942    173 -----------RAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARL 232
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 2-757 8.95e-08

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 57.11  E-value: 8.95e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402    2 LLGEEAMMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSL---KRSLEQARMEVSQEddkalq 78
Cdd:pfam01576   94 LQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLskeRKLLEERISEFTSN------ 167

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   79 lLHDIREQSRKLQEIKEQeYQAQVEEMRLMMNQLE---EDLVSARRRSDLYESELRES----RLAAEEFKRKANECQHKL 151
Cdd:pfam01576  168 -LAEEEEKAKSLSKLKNK-HEAMISDLEERLKKEEkgrQELEKAKRKLEGESTDLQEQiaelQAQIAELRAQLAKKEEEL 245

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  152 MKAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEkavkasteatellqNIRQAKERAEREleklhnREDSSEgikkkl 231
Cdd:pfam01576  246 QAALARLEEETAQKNNALKKIRELEAQISELQEDLE--------------SERAARNKAEKQ------RRDLGE------ 299

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  232 vEAEERRHSLENKVKRLETMErrenrlkdDIQTKSEQIQQMADKILELEEKHREAQVSaqhlevhlkQKEQHYEEKIKVL 311
Cdd:pfam01576  300 -ELEALKTELEDTLDTTAAQQ--------ELRSKREQEVTELKKALEEETRSHEAQLQ---------EMRQKHTQALEEL 361

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  312 DNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVEL-SEANKLAANSSLFTQRNMKAQEE 390
Cdd:pfam01576  362 TEQLEQAKRNKANLEKAKQALESENAELQAELRTLQQAKQDSEHKRKKLEGQLQELqARLSESERQRAELAEKLSKLQSE 441

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  391 ------MISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELE---TRLREVSLEHEEQKLELKRQLTE 461
Cdd:pfam01576  442 lesvssLLNEAEGKNIKLSKDVSSLESQLQDTQELLQEETRQKLNLSTRLRQLEderNSLQEQLEEEEEAKRNVERQLST 521

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  462 LQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQA---------------------------LTAHRDE 514
Cdd:pfam01576  522 LQAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAydklektknrlqqelddllvdldhqrqLVSNLEK 601

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  515 IQRKFD-ALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEI----VQLRSEVDHLrreiteremqLT 589
Cdd:pfam01576  602 KQKKFDqMLAEEKAISARYAEERDRAEAEAREKETRALSLARALEEALEAKEELertnKQLRAEMEDL----------VS 671

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  590 SQKQAQLSAPDL--------QTMEALKTTCTMLEEQvldLEALNDELLEKERQWEAW----------RSVLGDEK-SQFE 650
Cdd:pfam01576  672 SKDDVGKNVHELerskraleQQVEEMKTQLEELEDE---LQATEDAKLRLEVNMQALkaqferdlqaRDEQGEEKrRQLV 748

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  651 CRVRELQRMLDTEKQSRARAdqriTESRQVVELAVKEHKAEILALQQ----ALKEQKLKAESLSDKLNDLEKKHAMLEmn 726
Cdd:pfam01576  749 KQVRELEAELEDERKQRAQA----VAAKKKLELDLKELEAQIDAANKgreeAVKQLKKLQAQMKDLQRELEEARASRD-- 822

                          810       820       830
                   ....*....|....*....|....*....|.
gi 1039770402  727 aRSLQQKLETERELKQRlleEQAKLQQQMDL 757
Cdd:pfam01576  823 -EILAQSKESEKKLKNL---EAELLQLQEDL 849
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 58-755 9.99e-08

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 57.16  E-value: 9.99e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   58 LKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQeyqaqVEEMRLMMNQLEEDLVSARRRSdlyeselrESRLaa 137
Cdd:pfam12128  214 PKSRLNRQQVEHWIRDIQAIAGIMKIRPEFTKLQQEFNT-----LESAELRLSHLHFGYKSDETLI--------ASRQ-- 278

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  138 EEFKRKANECQHKLMKAKDQGKPEVGEysklekinAEQQLKIQElqekleKAVKASTEATELLQNirQAKERAERELEKL 217
Cdd:pfam12128  279 EERQETSAELNQLLRTLDDQWKEKRDE--------LNGELSAAD------AAVAKDRSELEALED--QHGAFLDADIETA 342

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  218 HNREDSSEGIKKKLVEAEERRHSLENKVKRLE-TMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSA-QHLEV 295
Cdd:pfam12128  343 AADQEQLPSWQSELENLEERLKALTGKHQDVTaKYNRRRSKIKEQNNRDIAGIKDKLAKIREARDRQLAVAEDDlQALES 422

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  296 HLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAA 375
Cdd:pfam12128  423 ELREQLEAGKLEFNEEEYRLKSRLGELKLRLNQATATPELLLQLENFDERIERAREEQEAANAEVERLQSELRQARKRRD 502

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  376 NSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKlEEQLEKISHQDHSDKSRLL--ELETRLREVSLEHEEQ-- 451
Cdd:pfam12128  503 QASEALRQASRRLEERQSALDELELQLFPQAGTLLHFLRK-EAPDWEQSIGKVISPELLHrtDLDPEVWDGSVGGELNly 581

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  452 --KLELKR----QLTELQLSLQERESQL-TALQAAR---AALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDA 521
Cdd:pfam12128  582 gvKLDLKRidvpEWAASEEELRERLDKAeEALQSARekqAAAEEQLVQANGELEKASREETFARTALKNARLDLRRLFDE 661

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  522 LRNsctvitdLEEQLNQLTEDNAELNNQNFylsKQLDEASGANDEIVQLRSEvdHLRREITEREMQLTSQKQAQLSAPDL 601
Cdd:pfam12128  662 KQS-------EKDKKNKALAERKDSANERL---NSLEAQLKQLDKKHQAWLE--EQKEQKREARTEKQAYWQVVEGALDA 729

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  602 QtMEALKTTCTMLEEQvldLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRaradQRITESRQVV 681
Cdd:pfam12128  730 Q-LALLKAAIAARRSG---AKAELKALETWYKRDLASLGVDPDVIAKLKREIRTLERKIERIAVRR----QEVLRYFDWY 801

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770402  682 ELAVKEHKaeilalqQALKEQKLKAESlsdKLNDLEKKHAMLEMNARSLQQKLETER----ELKQRLLEEQAKLQQQM 755
Cdd:pfam12128  802 QETWLQRR-------PRLATQLSNIER---AISELQQQLARLIADTKLRRAKLEMERkaseKQQVRLSENLRGLRCEM 869
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 675-886 1.13e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 55.93  E-value: 1.13e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  675 TESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQ 754
Cdd:COG4942     19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  755 MDLQKNHIFRLTQGLQ------------------EALDRADLLKTERSDLEYQLENIQvlysHEKVKMEGTISQQTKLID 816
Cdd:COG4942     99 LEAQKEELAELLRALYrlgrqpplalllspedflDAVRRLQYLKYLAPARREQAEELR----ADLAELAALRAELEAERA 174

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  817 FLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAA 886
Cdd:COG4942    175 ELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTP 244
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 6-301 1.19e-07

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 56.67  E-value: 1.19e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402    6 EAMMEQEMTRLHRRVSEVEAVLSQKEVELK--ASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLhdi 83
Cdd:pfam17380  322 EKARQAEMDRQAAIYAEQERMAMERERELEriRQEERKRELERIRQEEIAMEISRMRELERLQMERQQKNERVRQEL--- 398

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   84 rEQSRKlQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLaaEEFKRKANECQHKLMKAKDQGKPEVG 163
Cdd:pfam17380  399 -EAARK-VKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEERAREM--ERVRLEEQERQQQVERLRQQEEERKR 474

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  164 EYSKLEKINAEQQLKIQELQEKLEKAVKASTEATellqnirQAKERAERELEKlhnredSSEGIKKKLVEAEERRHSLEN 243
Cdd:pfam17380  475 KKLELEKEKRDRKRAEEQRRKILEKELEERKQAM-------IEEERKRKLLEK------EMEERQKAIYEEERRREAEEE 541

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770402  244 KVKRLETMERREnrlkddIQtksEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKE 301
Cdd:pfam17380  542 RRKQQEMEERRR------IQ---EQMRKATEERSRLEAMEREREMMRQIVESEKARAE 590
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
 409-756 1.38e-07

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 55.84  E-value: 1.38e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  409 LEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEeqklELKRQLTELQLSLQERESQLTALQAARAALESQLR 488
Cdd:pfam19220   25 LKADFSQLIEPIEAILRELPQAKSRLLELEALLAQERAAYG----KLRRELAGLTRRLSAAEGELEELVARLAKLEAALR 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  489 QAKTELEETTAeaeeeiqaltahrdeiqrkfdALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASgandeiv 568
Cdd:pfam19220  101 EAEAAKEELRI---------------------ELRDKTAQAEALERQLAAETEQNRALEEENKALREEAQAAE------- 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  569 QLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTCTMLE-EQVLD-----LEALNDELLEK-------ERQW 635
Cdd:pfam19220  153 KALQRAEGELATARERLALLEQENRRLQALSEEQAAELAELTRRLAElETQLDatrarLRALEGQLAAEqaereraEAQL 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  636 EAWRSVLGDEKSQFECRVRELQ-RMLDTEK---QSRARADQRiTESRQVVELAVKEHKAEILALQQALKEQKLKAESLSD 711
Cdd:pfam19220  233 EEAVEAHRAERASLRMKLEALTaRAAATEQllaEARNQLRDR-DEAIRAAERRLKEASIERDTLERRLAGLEADLERRTQ 311

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 1039770402  712 KLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMD 756
Cdd:pfam19220  312 QFQEMQRARAELEERAEMLTKALAAKDAALERAEERIASLSDRIA 356
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
2-366 1.56e-07

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 56.20  E-value: 1.56e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402    2 LLGEEAMMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATY----------ITECSSLKRSLEQARMEVSQ 71
Cdd:PRK02224   347 LREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELrerfgdapvdLGNAEDFLEELREERDELRE 426

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   72 ---EDDKALQLLHDIREQSRKL----------QEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELREsrlaAE 138
Cdd:PRK02224   427 reaELEATLRTARERVEEAEALleagkcpecgQPVEGSPHVETIEEDRERVEELEAELEDLEEEVEEVEERLER----AE 502

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  139 EFKRKANECQHKLMKAKDQGKpevgEYSKLEKINAEQQLKIQELQEKLE----KAVKASTEATELLQNIRQAKERA---E 211
Cdd:PRK02224   503 DLVEAEDRIERLEERREDLEE----LIAERRETIEEKRERAEELRERAAeleaEAEEKREAAAEAEEEAEEAREEVaelN 578

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  212 RELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILE--LEEKHREAQVS 289
Cdd:PRK02224   579 SKLAELKERIESLERIRTLLAAIADAEDEIERLREKREALAELNDERRERLAEKRERKRELEAEFDEarIEEAREDKERA 658

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  290 AQHLEvHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHE--EEAHEKGKILSEQKAMINAMDSKIRS-LEQRIVE 366
Cdd:PRK02224   659 EEYLE-QVEEKLDELREERDDLQAEIGAVENELEELEELRERREalENRVEALEALYDEAEELESMYGDLRAeLRQRNVE 737
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 323-905 2.09e-07

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 56.13  E-value: 2.09e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  323 ESLENMMQRHEEEAHEKGKILSEQ--------KAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMiSE 394
Cdd:TIGR00618  179 TQLALMEFAKKKSLHGKAELLTLRsqlltlctPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKREAQEEQ-LK 257

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  395 LRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHsdKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQEREsqlt 474
Cdd:TIGR00618  258 KQQLLKQLRARIEELRAQEAVLEETQERINRARK--AAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRA---- 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  475 ALQAARAALESQLRQAKTELEETTAEAEEEIQALT--AHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFY 552
Cdd:TIGR00618  332 AHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSirEISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQAT 411

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  553 LSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTctMLEEQVLDLEALNDELLEKE 632
Cdd:TIGR00618  412 IDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLK--EREQQLQTKEQIHLQETRKK 489

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  633 RQWEAWRSVLGDEKSQFECRVREL--QRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLS 710
Cdd:TIGR00618  490 AVVLARLLELQEEPCPLCGSCIHPnpARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQ 569

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  711 DKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKL---QQQMDLQKN---HIFRLTQGLQEALDRADLLKT--- 781
Cdd:TIGR00618  570 QSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLaceQHALLRKLQpeqDLQDVRLHLQQCSQELALKLTalh 649

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  782 -ERSDLEYQLENIQVLYSHEKVKMEGTISQqtKLIDFLQAKMDQPAKKKKGLFSR----RKEDPALPTQVPlQYNELKLA 856
Cdd:TIGR00618  650 aLQLTLTQERVREHALSIRVLPKELLASRQ--LALQKMQSEKEQLTYWKEMLAQCqtllRELETHIEEYDR-EFNEIENA 726

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*....
gi 1039770402  857 LEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQ 905
Cdd:TIGR00618  727 SSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQ 775
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
555-801 2.09e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 56.08  E-value: 2.09e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  555 KQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSapdlQTMEALKTTCTMLEEQVLDLEALNDELLEKERQ 634
Cdd:COG4913    252 ELLEPIRELAERYAAARERLAELEYLRAALRLWFAQRRLELLE----AELEELRAELARLEAELERLEARLDALREELDE 327

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  635 WE-AWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRItesrQVVELAVKEHKAEILALQQALKEQKLKAESLSDKl 713
Cdd:COG4913    328 LEaQIRGNGGDRLEQLEREIERLERELEERERRRARLEALL----AALGLPLPASAEEFAALRAEAAALLEALEEELEA- 402

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  714 ndlekkhamlemnarsLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDR-ADLLKTERSDLEYQLEN 792
Cdd:COG4913    403 ----------------LEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLALRDAlAEALGLDEAELPFVGEL 466


                   ....*....
gi 1039770402  793 IQVLYSHEK 801
Cdd:COG4913    467 IEVRPEEER 475
PH smart00233
Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The ...
 1036-1155 2.81e-07

Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids.


Pssm-ID: 214574 [Multi-domain]  Cd Length: 102  Bit Score: 50.24  E-value: 2.81e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  1036 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELClpdgDVSIhgavgaSELANTAKADVPY 1115
Cdd:smart00233    1 VIKEGWLYKKSGGGKK--SWKKRYFVLFNSTLLYYKSKKDKKSYKPKGSIDLS----GCTV------REAPDPDSSKKPH 68

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|
gi 1039770402  1116 ILKMeshphtTCWPGRTLYLLAPSFPDKQRWVTALESVVA 1155
Cdd:smart00233   69 CFEI------KTSDRKTLLLQAESEEEREKWVEALRKAIA 102
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 374-599 2.86e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 54.77  E-value: 2.86e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  374 AANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKL 453
Cdd:COG4942     18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRA 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  454 ELKRQLTELQ-----LSLQERESQLTALQAARAALESQ-----LRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALR 523
Cdd:COG4942     98 ELEAQKEELAellraLYRLGRQPPLALLLSPEDFLDAVrrlqyLKYLAPARREQAEELRADLAELAALRAELEAERAELE 177

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770402  524 nscTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASganDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAP 599
Cdd:COG4942    178 ---ALLAELEEERAALEALKAERQKLLARLEKELAELA---AELAELQQEAEELEALIARLEAEAAAAAERTPAAG 247
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
515-756 4.19e-07

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 55.02  E-value: 4.19e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  515 IQRKFDALRNSctvITDLEEQLNQLTE--DNAELNNQNFYLSKQL----DEASGANDEIVQLRSEVDHLRREITEREMQL 588
Cdd:COG3206    166 LELRREEARKA---LEFLEEQLPELRKelEEAEAALEEFRQKNGLvdlsEEAKLLLQQLSELESQLAEARAELAEAEARL 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  589 tSQKQAQLSAPDLQTMEALKTTctmleeqvlDLEALNDELLEKERQWEAWRSVLGDEKSQfecrVRELQRMLDTEKQSRA 668
Cdd:COG3206    243 -AALRAQLGSGPDALPELLQSP---------VIQQLRAQLAELEAELAELSARYTPNHPD----VIALRAQIAALRAQLQ 308

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  669 RADQRITESRQVvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLekkhamlemnaRSLQQKLETERELKQRLLE-- 746
Cdd:COG3206    309 QEAQRILASLEA---ELEALQAREASLQAQLAQLEARLAELPELEAEL-----------RRLEREVEVARELYESLLQrl 374

                          250
                   ....*....|
gi 1039770402  747 EQAKLQQQMD 756
Cdd:COG3206    375 EEARLAEALT 384
mukB PRK04863
chromosome partition protein MukB;
204-585 4.98e-07

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 54.96  E-value: 4.98e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  204 RQAKERAERELEKLHNREDSSeGIKKKLVEAEERrhsLENKVKRLETMERRENRLKDDIQTKS-------------EQIQ 270
Cdd:PRK04863   276 RHANERRVHLEEALELRRELY-TSRRQLAAEQYR---LVEMARELAELNEAESDLEQDYQAASdhlnlvqtalrqqEKIE 351

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  271 QMADKILELEEK-------HREAQVSAQHLEVHLKQKEQHYEEkikvldnqIKKDLADKESLENMMQRHEEEAHEKGKIL 343
Cdd:PRK04863   352 RYQADLEELEERleeqnevVEEADEQQEENEARAEAAEEEVDE--------LKSQLADYQQALDVQQTRAIQYQQAVQAL 423

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  344 SEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQN-----RKLEE 418
Cdd:PRK04863   424 ERAKQLCGLPDLTADNAEDWLEEFQAKEQEATEELLSLEQKLSVAQAAHSQFEQAYQLVRKIAGEVSRSEawdvaRELLR 503

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  419 QLEKISHQDhsdkSRLLELETRLREVSLEHEEQKlELKRQLTELQLSLQ---ERESQLTALQAARAALESQLRQAKTELE 495
Cdd:PRK04863   504 RLREQRHLA----EQLQQLRMRLSELEQRLRQQQ-RAERLLAEFCKRLGknlDDEDELEQLQEELEARLESLSESVSEAR 578

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  496 ETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVD 575
Cdd:PRK04863   579 ERRMALRQQLEQLQARIQRLAARAPAWLAAQDALARLREQSGEEFEDSQDVTEYMQQLLERERELTVERDELAARKQALD 658

                          410
                   ....*....|
gi 1039770402  576 HLRREITERE 585
Cdd:PRK04863   659 EEIERLSQPG 668
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 10-838 6.29e-07

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 54.67  E-value: 6.29e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   10 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQarmEVSQEDDKALQLLHDIREQsrk 89
Cdd:TIGR01612  806 DEDAKQNYDKSKEYIKTISIKEDEIFKIINEMKFMKDDFLNKVDKFINFENNCKE---KIDSEHEQFAELTNKIKAE--- 879

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   90 LQEIKEQEYQAQVEEMRLMMNQ----LEEDL--VSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKAKDQGKpEVG 163
Cdd:TIGR01612  880 ISDDKLNDYEKKFNDSKSLINEinksIEEEYqnINTLKKVDEYIKICENTKESIEKFHNKQNILKEILNKNIDTIK-ESN 958

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  164 EYSKLEKINAEQQL--KIQELQEKLEKAVKASTEA--TELLQNIRQAKERAERELEK-LHNREDSSEgikKKLVEAEERR 238
Cdd:TIGR01612  959 LIEKSYKDKFDNTLidKINELDKAFKDASLNDYEAknNELIKYFNDLKANLGKNKENmLYHQFDEKE---KATNDIEQKI 1035

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  239 HSLENKVKRLETMerrenrLKDDIQTKSEQIQQMADKILELEEKH--REAQVSAQHLEvHLKQKEQHY-------EEKIK 309
Cdd:TIGR01612 1036 EDANKNIPNIEIA------IHTSIYNIIDEIEKEIGKNIELLNKEilEEAEINITNFN-EIKEKLKHYnfddfgkEENIK 1108

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  310 VLD--NQIKKDLadkeslENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQrivelsEANKLAANSSLftQRNMKA 387
Cdd:TIGR01612 1109 YADeiNKIKDDI------KNLDQKIDHHIKALEEIKKKSENYIDEIKAQINDLED------VADKAISNDDP--EEIEKK 1174

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  388 QEEMISELRQQKfYLETQAGKLEAQNRKLEE---QLEKIshqdhsdKSRLLELETRLREVSLEH--EEQKlelkrqltel 462
Cdd:TIGR01612 1175 IENIVTKIDKKK-NIYDEIKKLLNEIAEIEKdktSLEEV-------KGINLSYGKNLGKLFLEKidEEKK---------- 1236

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  463 qlslqERESQLTALQAARAALESQLRQAKTELEET--TAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLT 540
Cdd:TIGR01612 1237 -----KSEHMIKAMEAYIEDLDEIKEKSPEIENEMgiEMDIKAEMETFNISHDDDKDHHIISKKHDENISDIREKSLKII 1311

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  541 EDNAELNNQNFY---LSKQLDEASGANDEIVQLRSEVDHL-------------------RREITEREMQLTSQ------- 591
Cdd:TIGR01612 1312 EDFSEESDINDIkkeLQKNLLDAQKHNSDINLYLNEIANIynilklnkikkiidevkeyTKEIEENNKNIKDEldksekl 1391

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  592 -------------KQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVL------GDEKSQFECR 652
Cdd:TIGR01612 1392 ikkikddinleecKSKIESTLDDKDIDECIKKIKELKNHILSEESNIDTYFKNADENNENVLLLfkniemADNKSQHILK 1471

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  653 VR-------------ELQRMLDTEKQSRARADQRITESRQVVELaVKEHKAEILALQQALKEQKLK---AESLSDK---L 713
Cdd:TIGR01612 1472 IKkdnatndhdfninELKEHIDKSKGCKDEADKNAKAIEKNKEL-FEQYKKDVTELLNKYSALAIKnkfAKTKKDSeiiI 1550

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  714 NDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQ----MDLQKNhifrlTQGLQEALDRADLLKTERSDLEYQ 789
Cdd:TIGR01612 1551 KEIKDAHKKFILEAEKSEQKIKEIKKEKFRIEDDAAKNDKSnkaaIDIQLS-----LENFENKFLKISDIKKKINDCLKE 1625

                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|
gi 1039770402  790 LENIQVLYSHEKVKMEGT-ISQQTKLIDFLQAKMDQPAKKKKGLFSRRKE 838
Cdd:TIGR01612 1626 TESIEKKISSFSIDSQDTeLKENGDNLNSLQEFLESLKDQKKNIEDKKKE 1675
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 6-491 6.91e-07

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 54.46  E-value: 6.91e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402    6 EAMMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQD-----------LATYITECSSLKRSL------------ 62
Cdd:pfam12128  296 DDQWKEKRDELNGELSAADAAVAKDRSELEALEDQHGAFLDAdietaaadqeqLPSWQSELENLEERLkaltgkhqdvta 375

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   63 --EQARMEVSQEDDKALQLLHD----IREQSRKLQEIKEQEYQAQVEEMRlmmNQLEEDLVSARRRSDLYESELRESRL- 135
Cdd:pfam12128  376 kyNRRRSKIKEQNNRDIAGIKDklakIREARDRQLAVAEDDLQALESELR---EQLEAGKLEFNEEEYRLKSRLGELKLr 452

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  136 -----AAEEFKRKANECQHKLMKAKdqgkpevgeySKLEKINAEQqlkiQELQEKLEKAVKASTEATELLQNIRQAKERA 210
Cdd:pfam12128  453 lnqatATPELLLQLENFDERIERAR----------EEQEAANAEV----ERLQSELRQARKRRDQASEALRQASRRLEER 518

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  211 ERELEKLHNR----------------EDSSEGIKKKLVEAEERR------------------HSLENKVKRL-------- 248
Cdd:pfam12128  519 QSALDELELQlfpqagtllhflrkeaPDWEQSIGKVISPELLHRtdldpevwdgsvggelnlYGVKLDLKRIdvpewaas 598

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  249 -ETMERRENRLKDDIQTKSEQIQ----QMADKILELEEKHREAQVSAQHL--------------EVHLKQKEQHYEEKIK 309
Cdd:pfam12128  599 eEELRERLDKAEEALQSAREKQAaaeeQLVQANGELEKASREETFARTALknarldlrrlfdekQSEKDKKNKALAERKD 678

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  310 VLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQK-----AMINAMDSKIRSLEQRIVELSEANKlAANSSLFTQ-- 382
Cdd:pfam12128  679 SANERLNSLEAQLKQLDKKHQAWLEEQKEQKREARTEKqaywqVVEGALDAQLALLKAAIAARRSGAK-AELKALETWyk 757

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  383 RNMKAQ---EEMISELRQQKFYLETqagKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQL 459
Cdd:pfam12128  758 RDLASLgvdPDVIAKLKREIRTLER---KIERIAVRRQEVLRYFDWYQETWLQRRPRLATQLSNIERAISELQQQLARLI 834

                          570       580       590
                   ....*....|....*....|....*....|..
gi 1039770402  460 TELQLSLQERESQLTALQAARAALESQLRQAK 491
Cdd:pfam12128  835 ADTKLRRAKLEMERKASEKQQVRLSENLRGLR 866
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 177-326 8.86e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 51.85  E-value: 8.86e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  177 LKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNRedsSEGIKKKLVEAEERRHSLENKVKRLET--MERR 254
Cdd:COG1579     10 LDLQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTE---LEDLEKEIKRLELEIEEVEARIKKYEEqlGNVR 86

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770402  255 ENR----LKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLE 326
Cdd:COG1579     87 NNKeyeaLQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELE 162
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 164-326 9.36e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 51.85  E-value: 9.36e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  164 EYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEgikKKLVEAeerrhsleN 243
Cdd:COG1579     18 ELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYE---EQLGNV--------R 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  244 KVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKE 323
Cdd:COG1579     87 NNKEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAERE 166


                   ...
gi 1039770402  324 SLE 326
Cdd:COG1579    167 ELA 169
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 320-517 1.44e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.46  E-value: 1.44e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  320 ADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQk 399
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE- 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  400 fyLETQAGKLEAQNRKL-----EEQLEKISHQDHSDKS------------RLLELETRLREVSLEHEEQKLELKRQLTEL 462
Cdd:COG4942     99 --LEAQKEELAELLRALyrlgrQPPLALLLSPEDFLDAvrrlqylkylapARREQAEELRADLAELAALRAELEAERAEL 176

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1039770402  463 QLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQR 517
Cdd:COG4942    177 EALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIAR 231
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 169-828 1.80e-06

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 53.13  E-value: 1.80e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  169 EKINAEQQLKIQELQEKLEKAVKASTEATEL-LQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKR 247
Cdd:TIGR00606  177 EIFSATRYIKALETLRQVRQTQGQKVQEHQMeLKYLKQYKEKACEIRDQITSKEAQLESSREIVKSYENELDPLKNRLKE 256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  248 LETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAqvsAQHLEVHLKQKEQHYEEKIKvldnQIKKDLAD-KESLE 326
Cdd:TIGR00606  257 IEHNLSKIMKLDNEIKALKSRKKQMEKDNSELELKMEKV---FQGTDEQLNDLYHNHQRTVR----EKERELVDcQRELE 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  327 NMMQRHEEEAHEKGKILSEQKAM----------INAMDSKIRSLEQR-----------------------IVELSEANKL 373
Cdd:TIGR00606  330 KLNKERRLLNQEKTELLVEQGRLqlqadrhqehIRARDSLIQSLATRleldgfergpfserqiknfhtlvIERQEDEAKT 409

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  374 AANSSLFTQRNMKAQEEMISELRQQKFYLetqAGKLEAQNRKLEEQLEKISH------QDHSDKSRLLELETRL----RE 443
Cdd:TIGR00606  410 AAQLCADLQSKERLKQEQADEIRDEKKGL---GRTIELKKEILEKKQEELKFvikelqQLEGSSDRILELDQELrkaeRE 486

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  444 VSLEHE---------------EQKLELKRQLTELQLSLQERE------SQLTALQAARAALESQLRQAKTELEETTAEAE 502
Cdd:TIGR00606  487 LSKAEKnsltetlkkevkslqNEKADLDRKLRKLDQEMEQLNhhtttrTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLL 566

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  503 EEI-------QALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVD 575
Cdd:TIGR00606  567 GYFpnkkqleDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLFDVCGSQDEESDLERLKE 646

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  576 HLRREITEREM-------------QLTSQKQA--QLSAPDLQTMEALKTTCTMLEEQVL----DLEALNDELLEKERQWE 636
Cdd:TIGR00606  647 EIEKSSKQRAMlagatavysqfitQLTDENQSccPVCQRVFQTEAELQEFISDLQSKLRlapdKLKSTESELKKKEKRRD 726

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  637 AWRSVLGDEKSQFECRVRELQRMLD-TEKQSRARADQRITESRQVVELAV---KEHKAEIL--------ALQQALKEQKL 704
Cdd:TIGR00606  727 EMLGLAPGRQSIIDLKEKEIPELRNkLQKVNRDIQRLKNDIEEQETLLGTimpEEESAKVCltdvtimeRFQMELKDVER 806

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  705 KAESLSDKLN--DLEKKHAMLEMNARSLQQKLET---ERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLL 779
Cdd:TIGR00606  807 KIAQQAAKLQgsDLDRTVQQVNQEKQEKQHELDTvvsKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQF 886

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*....
gi 1039770402  780 KTErsdLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKK 828
Cdd:TIGR00606  887 EEQ---LVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSK 932
C1_1 pfam00130
Phorbol esters/diacylglycerol binding domain (C1 domain); This domain is also known as the ...
 950-1005 1.94e-06

Phorbol esters/diacylglycerol binding domain (C1 domain); This domain is also known as the Protein kinase C conserved region 1 (C1) domain.


Pssm-ID: 395079  Cd Length: 53  Bit Score: 46.28  E-value: 1.94e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039770402  950 HHNIPHRFNvglnmRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCGL 1005
Cdd:pfam00130    1 HHFVHRNFK-----QPTFCDHCGEFLwGLGKQGLKCSWCKLNVHKRCHEKVPPECGC 52
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 346-618 2.24e-06

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 52.75  E-value: 2.24e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  346 QKAMINAMDSKIRSLEQRIVELSEANKLaansslftQRNMKAQEEMISELRQQKFYLETQAGKLEAQ--NRKLEEQLEKI 423
Cdd:PRK10929    43 QAEIVEALQSALNWLEERKGSLERAKQY--------QQVIDNFPKLSAELRQQLNNERDEPRSVPPNmsTDALEQEILQV 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  424 SHQdHSDKSRLLELET-RLREVS---LEHEEQKLELKRQLTELQLSLQERESQLTAL-QAARAAL--ESQLRQAKTELEE 496
Cdd:PRK10929   115 SSQ-LLEKSRQAQQEQdRAREISdslSQLPQQQTEARRQLNEIERRLQTLGTPNTPLaQAQLTALqaESAALKALVDELE 193

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  497 TTAEAEEEIQALTAHRDEI-QRKFDALRNSctvITDLEEQLNQLTEDNAElnnQNFYLSKQLDEASG--ANDEIVQLRse 573
Cdd:PRK10929   194 LAQLSANNRQELARLRSELaKKRSQQLDAY---LQALRNQLNSQRQREAE---RALESTELLAEQSGdlPKSIVAQFK-- 265

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1039770402  574 vdhLRREITE------REMQLTSQKQAQLSAPDLQTMEALKTtctmLEEQV 618
Cdd:PRK10929   266 ---INRELSQalnqqaQRMDLIASQQRQAASQTLQVRQALNT----LREQS 309
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 148-455 2.86e-06

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 52.05  E-value: 2.86e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  148 QHKLMKAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERaeRELEKLHNREDSSEGI 227
Cdd:pfam17380  298 QERLRQEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAMERERELERIRQEERK--RELERIRQEEIAMEIS 375

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  228 K-KKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVsaQHLEvhlkqkeqhyEE 306
Cdd:pfam17380  376 RmRELERLQMERQQKNERVRQELEAARKVKILEEERQRKIQQQKVEMEQIRAEQEEARQREV--RRLE----------EE 443

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  307 KIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMK 386
Cdd:pfam17380  444 RAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKLLEKEME 523

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039770402  387 AQEEMISELRQQKFYLETQAGKLEAQNRK-LEEQLEKISHQdhsdKSRL--LELETRLREVSLEHEEQKLEL 455
Cdd:pfam17380  524 ERQKAIYEEERRREAEEERRKQQEMEERRrIQEQMRKATEE----RSRLeaMEREREMMRQIVESEKARAEY 591
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 666-943 3.05e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 51.37  E-value: 3.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  666 SRARADQRITESRQvvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLET-ERELKQR- 743
Cdd:COG3883     10 TPAFADPQIQAKQK----ELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEaEAEIEERr 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  744 -LLEEQAKLQQQMDLQKNHIFRLT--QGLQEALDRADLLKTErsdleyqleniqvlyshekvkmegtISQQTKLIDFLQA 820
Cdd:COG3883     86 eELGERARALYRSGGSVSYLDVLLgsESFSDFLDRLSALSKI-------------------------ADADADLLEELKA 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  821 KMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPA 900
Cdd:COG3883    141 DKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAA 220

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 1039770402  901 TARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKESSTPEEFSR 943
Cdd:COG3883    221 AAAAAAAAAAAAAAAAAAAAAAAASAAGAGAAGAAGAAAGSAG 263
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 172-880 3.70e-06

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 51.75  E-value: 3.70e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  172 NAEQQLKIQELQEKLekavKASTEATELLQNIRQAKERAEREleKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETM 251
Cdd:pfam10174   69 NQHLQLTIQALQDEL----RAQRDLNQLLQQDFTTSPVDGED--KFSTPELTEENFRRLQSEHERQAKELFLLRKTLEEM 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  252 ERRENRLKDDIQTKSEQIQQMAD--------KILELEEKHR-----EAQVSAQHLEVHLKQKEqhyeekikvldnqiKKD 318
Cdd:pfam10174  143 ELRIETQKQTLGARDESIKKLLEmlqskglpKKSGEEDWERtrriaEAEMQLGHLEVLLDQKE--------------KEN 208

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  319 LADKESLENMMQRHEEEAHEKGkilseQKAMINAMDSKIRSLEQRIVELS-EANKLAANSSLFTqrnmkaqEEMISELRQ 397
Cdd:pfam10174  209 IHLREELHRRNQLQPDPAKTKA-----LQTVIEMKDTKISSLERNIRDLEdEVQMLKTNGLLHT-------EDREEEIKQ 276

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  398 QKFYletqagkleaqnrkleeqlekishQDHSDKsrlleletrlrevsleheeqkleLKRQLTELQLSLQERESQLTALQ 477
Cdd:pfam10174  277 MEVY------------------------KSHSKF-----------------------MKNKIDQLKQELSKKESELLALQ 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  478 AARAALESQLRQAKTELEETTaeaeeeiQALTAHRDE---IQRKFDALRNSC----TVITDLEEQLNQLTEDNAELNNQN 550
Cdd:pfam10174  310 TKLETLTNQNSDCKQHIEVLK-------ESLTAKEQRaaiLQTEVDALRLRLeekeSFLNKKTKQLQDLTEEKSTLAGEI 382

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  551 FYLSKQLDEAsgaNDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSapdLQTMEALKTTCtmleeqvldLEALNDELLE 630
Cdd:pfam10174  383 RDLKDMLDVK---ERKINVLQKKIENLQEQLRDKDKQLAGLKERVKS---LQTDSSNTDTA---------LTTLEEALSE 447

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  631 KERQWEAWRsvlgdEKSQFECRVR--ELQRMLDTEKQSRARAD--QRITESRQVVELAVKEHkAEILALQQALKEQKLKA 706
Cdd:pfam10174  448 KERIIERLK-----EQREREDRERleELESLKKENKDLKEKVSalQPELTEKESSLIDLKEH-ASSLASSGLKKDSKLKS 521

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  707 ---------ESLSDKLNDLEKKHAMlEMNARSLQQKLETERELKQ---RLLEEQAKLQQQMDlqknhifRLTQGLQEAld 774
Cdd:pfam10174  522 leiaveqkkEECSKLENQLKKAHNA-EEAVRTNPEINDRIRLLEQevaRYKEESGKAQAEVE-------RLLGILREV-- 591

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  775 radllKTERSDLEYQLENIQVLYSHEkvkmegtISQQTKLIDflQAKMDQPAKKKKGLfsrRKEDPALPTQVPLQYNELK 854
Cdd:pfam10174  592 -----ENEKNDKDKKIAELESLTLRQ-------MKEQNKKVA--NIKHGQQEMKKKGA---QLLEEARRREDNLADNSQQ 654

                          730       740
                   ....*....|....*....|....*.
gi 1039770402  855 LALEkekarcaELEEALQKTRIELRS 880
Cdd:pfam10174  655 LQLE-------ELMGALEKTRQELDA 673
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
96-302 3.73e-06

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 51.94  E-value: 3.73e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   96 QEYQAQVEEMRlmMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRkanecQHKLMKAKDQGKPEVGEYSKLEK--INA 173
Cdd:COG3206    159 EAYLEQNLELR--REEARKALEFLEEQLPELRKELEEAEAALEEFRQ-----KNGLVDLSEEAKLLLQQLSELESqlAEA 231

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  174 EQQL-----KIQELQEKLEKAVKASTEATE--LLQNIRQAKERAERELEKLHNR--EDSSE--GIKKKLVEAEERRHSLE 242
Cdd:COG3206    232 RAELaeaeaRLAALRAQLGSGPDALPELLQspVIQQLRAQLAELEAELAELSARytPNHPDviALRAQIAALRAQLQQEA 311

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039770402  243 NKVK-----RLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQ 302
Cdd:COG3206    312 QRILasleaELEALQAREASLQAQLAQLEARLAELPELEAELRRLEREVEVARELYESLLQRLEE 376
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 560-888 4.43e-06

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 51.76  E-value: 4.43e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  560 ASGANDEIVQL-----RSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALkttctMLEEQVLDLEALNDELLEKERQ 634
Cdd:pfam12128  204 AILEDDGVVPPksrlnRQQVEHWIRDIQAIAGIMKIRPEFTKLQQEFNTLESA-----ELRLSHLHFGYKSDETLIASRQ 278

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  635 wEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLN 714
Cdd:pfam12128  279 -EERQETSAELNQLLRTLDDQWKEKRDELNGELSAADAAVAKDRSELEALEDQHGAFLDADIETAAADQEQLPSWQSELE 357

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  715 DLEKKHAMLEMNARSLQQKLETEREL-KQRLLEEQAKLQQQMDLQKNHIFRltqglQEALDRADLLKTErSDLEYQLENI 793
Cdd:pfam12128  358 NLEERLKALTGKHQDVTAKYNRRRSKiKEQNNRDIAGIKDKLAKIREARDR-----QLAVAEDDLQALE-SELREQLEAG 431

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  794 QVLYSHEKVKMEGTISQQTKLIDFLQAkmdqpakkkkglfsrrkeDPALPTQVPLQYNELKLALEKEKARCAELEeALQK 873
Cdd:pfam12128  432 KLEFNEEEYRLKSRLGELKLRLNQATA------------------TPELLLQLENFDERIERAREEQEAANAEVE-RLQS 492

                          330
                   ....*....|....*
gi 1039770402  874 TRIELRSAREEAAHR 888
Cdd:pfam12128  493 ELRQARKRRDQASEA 507
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 387-623 5.06e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 50.92  E-value: 5.06e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  387 AQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVslehEEQKLELKRQLTELQLSL 466
Cdd:COG4942     17 AQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRAL----EQELAALEAELAELEKEI 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  467 QERESQLTALqaaRAALESQLRQAKTELEETTAeaeeeiqALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAEL 546
Cdd:COG4942     93 AELRAELEAQ---KEELAELLRALYRLGRQPPL-------ALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAEL 162

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039770402  547 NNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQlsapdLQTMEALKTTCTMLEEQVLDLEA 623
Cdd:COG4942    163 AALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAEL-----AAELAELQQEAEELEALIARLEA 234
COG5022 COG5022
Myosin heavy chain [General function prediction only];
10-789 5.78e-06

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 51.23  E-value: 5.78e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   10 EQEMTRLHRRVSEVEAVLSQ---KEVELKASETQRSLLEQDLATyitECSSLKRSL---EQARMEVSQEDDKALQLLHDI 83
Cdd:COG5022    799 LQPLLSLLGSRKEYRSYLACiikLQKTIKREKKLRETEEVEFSL---KAEVLIQKFgrsLKAKKRFSLLKKETIYLQSAQ 875

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   84 REQS--RKLQEIKEQEyqAQVEEMRLMMNQLEEDLVsaRRRSDLYESELRESRLAAEEFKRKanECQHKLMKAKDQGKPE 161
Cdd:COG5022    876 RVELaeRQLQELKIDV--KSISSLKLVNLELESEII--ELKKSLSSDLIENLEFKTELIARL--KKLLNNIDLEEGPSIE 949

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  162 VGEYSKLEKINaEQQLKIQELQEKLEKAVKASTEatellqnirqakeraerELEKLHNREDSSEGIKKKLVEAEERRHSL 241
Cdd:COG5022    950 YVKLPELNKLH-EVESKLKETSEEYEDLLKKSTI-----------------LVREGNKANSELKNFKKELAELSKQYGAL 1011

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  242 ENKVKRLETMERRENRLKDDIQTKSEqiqqmadkilELEEKHREAQVsaQHLEVHLKQKEQHYEEKIKVLDNQIkkdlad 321
Cdd:COG5022   1012 QESTKQLKELPVEVAELQSASKIISS----------ESTELSILKPL--QKLKGLLLLENNQLQARYKALKLRR------ 1073

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  322 keslenmmqrheeeahEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANklAANSSLFTQRNMKAqeemiselrQQKFY 401
Cdd:COG5022   1074 ----------------ENSLLDDKQLYQLESTENLLKTINVKDLEVTNRN--LVKPANVLQFIVAQ---------MIKLN 1126

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  402 LETQAGKLEAQNRKLEEQLEKishqdhSDKSRLLELETRLREVSLEHEEQKLELKRQltelqlsLQERESQLTALQAARA 481
Cdd:COG5022   1127 LLQEISKFLSQLVNTLEPVFQ------KLSVLQLELDGLFWEANLEALPSPPPFAAL-------SEKRLYQSALYDEKSK 1193

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  482 ALESQLRQAKTELeettaeaeeeiqaltahrDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEAS 561
Cdd:COG5022   1194 LSSSEVNDLKNEL------------------IALFSKIFSGWPRGDKLKKLISEGWVPTEYSTSLKGFNNLNKKFDTPAS 1255

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  562 GANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEkerQWeawrsv 641
Cdd:COG5022   1256 MSNEKLLSLLNSIDNLLSSYKLEEEVLPATINSLLQYINVGLFNALRTKASSLRWKSATEVNYNSEELD---DW------ 1326

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  642 lgdeksqfeCRVRELQRmLDTEKQSraradqrITESRQVVELAVK--EHKAEILALQQALKE---QKLKAE-SLSDKLND 715
Cdd:COG5022   1327 ---------CREFEISD-VDEELEE-------LIQAVKVLQLLKDdlNKLDELLDACYSLNPaeiQNLKSRyDPADKENN 1389

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770402  716 LEKKHaMLEMNARSLQQKLETERELKQRLleeQAKLQQQMDLQKNHIFRLTQGLQ--EALDR--ADLLKTERSDLEYQ 789
Cdd:COG5022   1390 LPKEI-LKKIEALLIKQELQLSLEGKDET---EVHLSEIFSEEKSLISLDRNSIYkeEVLSSlsALLTKEKIALLDRK 1463
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 506-735 8.03e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 50.15  E-value: 8.03e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  506 QALTAHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQLDEAsgaNDEIVQLRSEVDHLRREITERE 585
Cdd:COG4942     16 AAQADAAAEAEAELEQLQQE---IAELEKELAALKKEEKALLKQLAALERRIAAL---ARRIRALEQELAALEAELAELE 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  586 MQLtSQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQfecrVRELQRMLDTEKQ 665
Cdd:COG4942     90 KEI-AELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQ----AEELRADLAELAA 164

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  666 SRaradQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLE 735
Cdd:COG4942    165 LR----AELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIA 230
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 10-572 9.68e-06

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 50.56  E-value: 9.68e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   10 EQEMTRLHRRVSEVEAVLsQKEVELKASETQRSLleqDLATYITECSSLKRSLEQaRMEVSQEDDKALQllhdireqsRK 89
Cdd:pfam01576  453 EGKNIKLSKDVSSLESQL-QDTQELLQEETRQKL---NLSTRLRQLEDERNSLQE-QLEEEEEAKRNVE---------RQ 518

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   90 LQEIKEQ--EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKL---MKAKDQGKPEVGE 164
Cdd:pfam01576  519 LSTLQAQlsDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELddlLVDLDHQRQLVSN 598

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  165 YSKLEK----INAEQQLKIQELQEKLEKAVKASTEA-------TELLQNIRQAKERAER-------ELEKLHNREDSS-- 224
Cdd:pfam01576  599 LEKKQKkfdqMLAEEKAISARYAEERDRAEAEAREKetralslARALEEALEAKEELERtnkqlraEMEDLVSSKDDVgk 678

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  225 ----------------EGIKKKLVEAEERRHSLENKVKRLE-TMERRENRLKDDIQTKSEQ--------IQQMADKILEL 279
Cdd:pfam01576  679 nvhelerskraleqqvEEMKTQLEELEDELQATEDAKLRLEvNMQALKAQFERDLQARDEQgeekrrqlVKQVRELEAEL 758

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  280 EE--KHREAQVSA-QHLEVHLKQKEQHYEEKIKVLDNQIKKdLADKESLENMMQRHEEEAHekgkiLSEQKAMINAMDS- 355
Cdd:pfam01576  759 EDerKQRAQAVAAkKKLELDLKELEAQIDAANKGREEAVKQ-LKKLQAQMKDLQRELEEAR-----ASRDEILAQSKESe 832

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  356 -KIRSLEQRIVELSEanKLAANSSLFTQRNM---KAQEEMI------SELRQQKFYLETQAGKLEAQNRklEEQLEKISH 425
Cdd:pfam01576  833 kKLKNLEAELLQLQE--DLAASERARRQAQQerdELADEIAsgasgkSALQDEKRRLEARIAQLEEELE--EEQSNTELL 908

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  426 QDHSDKSRLL--ELETRL---REVSLEHEEQKLELKRQLTELQLSLQERESQ--------LTALQAARAALESQLRQ--- 489
Cdd:pfam01576  909 NDRLRKSTLQveQLTTELaaeRSTSQKSESARQQLERQNKELKAKLQEMEGTvkskfkssIAALEAKIAQLEEQLEQesr 988

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  490 -----AKTELEETTAEAEEEIQALTAHRDEIQRKfDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAN 564
Cdd:pfam01576  989 erqaaNKLVRRTEKKLKEVLLQVEDERRHADQYK-DQAEKGNSRMKQLKRQLEEAEEEASRANAARRKLQRELDDATESN 1067

                          650
                   ....*....|..
gi 1039770402  565 D----EIVQLRS 572
Cdd:pfam01576 1068 EsmnrEVSTLKS 1079
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 560-831 1.02e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.76  E-value: 1.02e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  560 ASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDlqtmealkttctmleeqvlDLEALNDELLEKERQweawr 639
Cdd:COG4942     15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLK-------------------QLAALERRIAALARR----- 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  640 svlgdeksqfecrVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKK 719
Cdd:COG4942     71 -------------IRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRR 137

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  720 HAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKnhifRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSH 799
Cdd:COG4942    138 LQYLKYLAPARREQAEELRADLAELAALRAELEAERAELE----ALLAELEEERAALEALKAERQKLLARLEKELAELAA 213

                          250       260       270
                   ....*....|....*....|....*....|..
gi 1039770402  800 EKVKMEGTISQQTKLIDFLQAKMDQPAKKKKG 831
Cdd:COG4942    214 ELAELQQEAEELEALIARLEAEAAAAAERTPA 245
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
15-364 1.12e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 50.15  E-value: 1.12e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   15 RLHRRVSEVEAVLSQKEV---ELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQ-LLHDIREQSRKL 90
Cdd:COG4717    129 PLYQELEALEAELAELPErleELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQdLAEELEELQQRL 208

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   91 QEIKEQEYQAQVEEMRLM--MNQLEEDLVSARRRSDLYE--------SELRESRLAAEEFKRKANE-------------- 146
Cdd:COG4717    209 AELEEELEEAQEELEELEeeLEQLENELEAAALEERLKEarlllliaAALLALLGLGGSLLSLILTiagvlflvlgllal 288

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  147 CQHKLMKAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKAS-TEATELLQNIRQAK------ERAERELEKLHN 219
Cdd:COG4717    289 LFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSpEELLELLDRIEELQellreaEELEEELQLEEL 368

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  220 REDSSEGIKKKLVEAEErrhSLENKVKRLEtmerRENRLKDDIQTKSEQIQQMADKILELEEKHREAQvsaqhlevhLKQ 299
Cdd:COG4717    369 EQEIAALLAEAGVEDEE---ELRAALEQAE----EYQELKEELEELEEQLEELLGELEELLEALDEEE---------LEE 432

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039770402  300 KEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEahekgKILSEQKAMINAMDSKIRSLEQRI 364
Cdd:COG4717    433 ELEELEEELEELEEELEELREELAELEAELEQLEED-----GELAELLQELEELKAELRELAEEW 492
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 529-760 1.19e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.38  E-value: 1.19e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  529 ITDLEEQLNQLTEDNAELNNQnfyLSKQLDEASGANDEIVQLRSEVDHLRREI--TEREMQLTSQKQAQLSAPdlqtMEA 606
Cdd:COG4942     22 AAEAEAELEQLQQEIAELEKE---LAALKKEEKALLKQLAALERRIAALARRIraLEQELAALEAELAELEKE----IAE 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  607 LKTTctmLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLdtekQSRARADQRITESRQVVELAVK 686
Cdd:COG4942     95 LRAE---LEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLA----PARREQAEELRADLAELAALRA 167

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039770402  687 EHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKN 760
Cdd:COG4942    168 ELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
256-794 1.19e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 50.04  E-value: 1.19e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  256 NRLKDDiqtKSEQIQQMADKILELEEKHREAQVSAqhlevhLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEE 335
Cdd:PRK02224   179 ERVLSD---QRGSLDQLKAQIEEKEEKDLHERLNG------LESELAELDEEIERYEEQREQARETRDEADEVLEEHEER 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  336 AHEkgkilseqkaminamdskIRSLEQRIVELSEanKLAAnsslfTQRNMKAQEEMISELRQQKFYLETQagkleaqnrk 415
Cdd:PRK02224   250 REE------------------LETLEAEIEDLRE--TIAE-----TEREREELAEEVRDLRERLEELEEE---------- 294

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  416 LEEQLEKISHQDHSDKSRLLELEtrlrevslEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELE 495
Cdd:PRK02224   295 RDDLLAEAGLDDADAEAVEARRE--------ELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAA 366

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  496 ETTaeaeeeiqaltahrDEIQRKFDALRNSCTVITDLEEQLNQLTE--DNAELnnqnfylskQLDEASGANDEivqLRSE 573
Cdd:PRK02224   367 ELE--------------SELEEAREAVEDRREEIEELEEEIEELRErfGDAPV---------DLGNAEDFLEE---LREE 420

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  574 VDHLRreitEREMQLTSqkqaqlsapDLQTmealkttctmLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRV 653
Cdd:PRK02224   421 RDELR----EREAELEA---------TLRT----------ARERVEEAEALLEAGKCPECGQPVEGSPHVETIEEDRERV 477

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  654 RELQRMLDTEKQSRARADQRITESRQVVELAVK----EHKAEilALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARS 729
Cdd:PRK02224   478 EELEAELEDLEEEVEEVEERLERAEDLVEAEDRierlEERRE--DLEELIAERRETIEEKRERAEELRERAAELEAEAEE 555

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039770402  730 LQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQgLQEALDRADLLKTERSDLEYQLENIQ 794
Cdd:PRK02224   556 KREAAAEAEEEAEEAREEVAELNSKLAELKERIESLER-IRTLLAAIADAEDEIERLREKREALA 619
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1512-1603 1.32e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 50.07  E-value: 1.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402 1512 ESGTEQHRVPSTSRSSPNKRGPP--TYNEHITKR--------------VASSPAPPEGPSHPREPSTPHRYRDREGRTEL 1575
Cdd:PTZ00449   527 KEGEEGEHEDSKESDEPKEGGKPgeTKEGEVGKKpgpakehkpskiptLSKKPEFPKDPKHPKDPEEPKKPKRPRSAQRP 606

                           90       100       110
                   ....*....|....*....|....*....|
gi 1039770402 1576 RRDKSPGRP--LEREKSPGRMLSTRRERSP 1603
Cdd:PTZ00449   607 TRPKSPKLPelLDIPKSPKRPESPKSPKRP 636
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
 141-336 1.44e-05

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 48.10  E-value: 1.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  141 KRKANECQHKLMKAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNR 220
Cdd:pfam00261    7 KEELDEAEERLKEAMKKLEEAEKRAEKAEAEVAALNRRIQLLEEELERTEERLAEALEKLEEAEKAADESERGRKVLENR 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  221 ----EDSSEGIKKKLVEAEERRHSLEnkvKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVH 296
Cdd:pfam00261   87 alkdEEKMEILEAQLKEAKEIAEEAD---RKYEEVARKLVVVEGDLERAEERAELAESKIVELEEELKVVGNNLKSLEAS 163

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1039770402  297 LK---QKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEA 336
Cdd:pfam00261  164 EEkasEREDKYEEQIRFLTEKLKEAETRAEFAERSVQKLEKEV 206
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
 197-542 1.59e-05

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 49.30  E-value: 1.59e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  197 TELLQNIRQAKERAErELEKLHNRE-DSSEGIKKKLVEAEERRHSLENKVKRLET-MERRENRLKDDIQTKSEQIQQMAD 274
Cdd:pfam19220   37 EAILRELPQAKSRLL-ELEALLAQErAAYGKLRRELAGLTRRLSAAEGELEELVArLAKLEAALREAEAAKEELRIELRD 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  275 KILELEEKHREAQVSAQHLEvHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMD 354
Cdd:pfam19220  116 KTAQAEALERQLAAETEQNR-ALEEENKALREEAQAAEKALQRAEGELATARERLALLEQENRRLQALSEEQAAELAELT 194

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  355 SKIRSLEQRI------VELSEANKLAANSSlfTQRNMKAQEEMISELRQQKfylETQAGKLEAQNRKLE--EQLekishq 426
Cdd:pfam19220  195 RRLAELETQLdatrarLRALEGQLAAEQAE--RERAEAQLEEAVEAHRAER---ASLRMKLEALTARAAatEQL------ 263

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  427 dhsdksrLLELETRLRevslEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQ 506
Cdd:pfam19220  264 -------LAEARNQLR----DRDEAIRAAERRLKEASIERDTLERRLAGLEADLERRTQQFQEMQRARAELEERAEMLTK 332

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1039770402  507 ALTAHRdeiqrkfDALRNSCTVITDLEEQLNQLTED 542
Cdd:pfam19220  333 ALAAKD-------AALERAEERIASLSDRIAELTKR 361
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 165-599 1.66e-05

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 49.74  E-value: 1.66e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  165 YSKLEKINAEQQLKIQELQEKLEKAvkasteatELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHS---- 240
Cdd:pfam05557    6 ESKARLSQLQNEKKQMELEHKRARI--------ELEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALREqael 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  241 LENKVKRLETMERRENRlKDDIQTKSEQIQ------------QMADKILELEEKHREAQVSAQHLEVhLKQKEQHYEEKI 308
Cdd:pfam05557   78 NRLKKKYLEALNKKLNE-KESQLADAREVIsclknelselrrQIQRAELELQSTNSELEELQERLDL-LKAKASEAEQLR 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  309 KVLDNQiKKDLADKE----SLENMMQRHEEEAHEKGKILSEQkAMINAMDSKIRSLEQRIVELSEANKlaaNSSLFTQ-- 382
Cdd:pfam05557  156 QNLEKQ-QSSLAEAEqrikELEFEIQSQEQDSEIVKNSKSEL-ARIPELEKELERLREHNKHLNENIE---NKLLLKEev 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  383 --------RNMKAQEEMIS-ELRQQKFYLETQAGKLEAQNRKLE--------EQLEKISHQDHSDKSRLLELETRLREVS 445
Cdd:pfam05557  231 edlkrkleREEKYREEAATlELEKEKLEQELQSWVKLAQDTGLNlrspedlsRRIEQLQQREIVLKEENSSLTSSARQLE 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  446 ---LEHEEQKLELKRQLTELQLSLQERESQLTALQ-----------AARAALES-----QLRQAKTELEETTAEAEEEIQ 506
Cdd:pfam05557  311 karRELEQELAQYLKKIEDLNKKLKRHKALVRRLQrrvllltkerdGYRAILESydkelTMSNYSPQLLERIEEAEDMTQ 390

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  507 ALTAHRDEIQRKFDALRNSCTVITD----LEEQLNQLTEDnaELNNQNFYLSKQLDEASGANDEivqLRSEVDHLRREIT 582
Cdd:pfam05557  391 KMQAHNEEMEAQLSVAEEELGGYKQqaqtLERELQALRQQ--ESLADPSYSKEEVDSLRRKLET---LELERQRLREQKN 465

                          490
                   ....*....|....*..
gi 1039770402  583 EREMQLTSQKQAQLSAP 599
Cdd:pfam05557  466 ELEMELERRCLQGDYDP 482
C1_SpBZZ1-like cd20824
protein kinase C conserved region 1 (C1 domain) found in Schizosaccharomyces pombe protein ...
 954-1004 2.00e-05

protein kinase C conserved region 1 (C1 domain) found in Schizosaccharomyces pombe protein BZZ1 and similar proteins; BZZ1 is a syndapin-like F-BAR protein that plays a role in endocytosis and trafficking to the vacuole. It functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress. BZZ1 contains an N-terminal F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs), a central coiled-coil, and two C-terminal SH3 domains. Schizosaccharomyces pombe BZZ1 also harbors a C1 domain, but Saccharomyces cerevisiae BZZ1 doesn't have any. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410374  Cd Length: 53  Bit Score: 43.46  E-value: 2.00e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039770402  954 PHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCG 1004
Cdd:cd20824      1 PHNFKPHSFSIPTKCDYCGEKIwGLSKKGLSCKDCGFNCHIKCELKVPPECP 52
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
58-317 2.08e-05

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 48.37  E-value: 2.08e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   58 LKRSLEQARMEVSQEDDKalqlLHDIREQSRKLQEiKEQEYQAQVEEMRLMMNQLEEdlvsarRRSDLYEsELRESRLAA 137
Cdd:COG1340     13 LEEKIEELREEIEELKEK----RDELNEELKELAE-KRDELNAQVKELREEAQELRE------KRDELNE-KVKELKEER 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  138 EEFKRKANECQHKLMKAKDQGKPEVG----------EYSKLEK--------INAEQQL--KIQELQEKLE---KAVKAST 194
Cdd:COG1340     81 DELNEKLNELREELDELRKELAELNKaggsidklrkEIERLEWrqqtevlsPEEEKELveKIKELEKELEkakKALEKNE 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  195 EATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLenkVKRLETMERRENRLKDDIQTKSEQIQQMAD 274
Cdd:COG1340    161 KLKELRAELKELRKEAEEIHKKIKELAEEAQELHEEMIELYKEADEL---RKEADELHKEIVEAQEKADELHEEIIELQK 237

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 1039770402  275 KILELEEKHREAQVSAQHLEVHLKQKEqhYEEKIKVLDNQIKK 317
Cdd:COG1340    238 ELRELRKELKKLRKKQRALKREKEKEE--LEEKAEEIFEKLKK 278
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 84-793 2.15e-05

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 49.44  E-value: 2.15e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   84 REQSRKLQEIKEQEYQAQVE--EMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKAKDQGKPE 161
Cdd:pfam10174   49 KEEAARISVLKEQYRVTQEEnqHLQLTIQALQDELRAQRDLNQLLQQDFTTSPVDGEDKFSTPELTEENFRRLQSEHERQ 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  162 VGEYSKLEKINAEQQLKIQELQEKLEkavkASTEATELLQNIRQAKERAERELEKLHNRedssegiKKKLVEAEERRHSL 241
Cdd:pfam10174  129 AKELFLLRKTLEEMELRIETQKQTLG----ARDESIKKLLEMLQSKGLPKKSGEEDWER-------TRRIAEAEMQLGHL 197

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  242 ENKV--KRLETMERRE-----NRLKDDiQTKSEQIQQMAD----KILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKV 310
Cdd:pfam10174  198 EVLLdqKEKENIHLREelhrrNQLQPD-PAKTKALQTVIEmkdtKISSLERNIRDLEDEVQMLKTNGLLHTEDREEEIKQ 276

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  311 LD-------------NQIKKDLADKESLENMMQRHEEEAHEKGkilSEQKAMINAMDSKIRSLEQRIVEL-SEANKLaan 376
Cdd:pfam10174  277 MEvykshskfmknkiDQLKQELSKKESELLALQTKLETLTNQN---SDCKQHIEVLKESLTAKEQRAAILqTEVDAL--- 350

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  377 sslftQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREvsleHEEQKLELK 456
Cdd:pfam10174  351 -----RLRLEEKESFLNKKTKQLQDLTEEKSTLAGEIRDLKDMLDVKERKINVLQKKIENLQEQLRD----KDKQLAGLK 421

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  457 RQLTELQLSLQERESQLTALQAARAALEsqlrqakteleettaeaeEEIQALTAHRD-EIQRKFDALRNSCTVITDLEEQ 535
Cdd:pfam10174  422 ERVKSLQTDSSNTDTALTTLEEALSEKE------------------RIIERLKEQRErEDRERLEELESLKKENKDLKEK 483

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  536 LNQLtedNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREItEREMQLTSQKQAQLsaPDLQTMEALKTTCTMLE 615
Cdd:pfam10174  484 VSAL---QPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAV-EQKKEECSKLENQL--KKAHNAEEAVRTNPEIN 557

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  616 EQVldlealndELLEKERQWEAWRSvlgdEKSQFEC-RVRELQRMLDTEKQSRaraDQRITEsrqvvelavkehkAEILA 694
Cdd:pfam10174  558 DRI--------RLLEQEVARYKEES----GKAQAEVeRLLGILREVENEKNDK---DKKIAE-------------LESLT 609

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  695 LQQaLKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQ--RLLEEQAKLQQQMDLQKNHIFRLTQGLQEa 772
Cdd:pfam10174  610 LRQ-MKEQNKKVANIKHGQQEMKKKGAQLLEEARRREDNLADNSQQLQleELMGALEKTRQELDATKARLSSTQQSLAE- 687

                          730       740
                   ....*....|....*....|.
gi 1039770402  773 ldRADLLKTERSDLEYQLENI 793
Cdd:pfam10174  688 --KDGHLTNLRAERRKQLEEI 706
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 346-549 2.17e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.61  E-value: 2.17e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  346 QKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISH 425
Cdd:COG4942     18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRA 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  426 QDHSDKSRLLEL-------ETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETT 498
Cdd:COG4942     98 ELEAQKEELAELlralyrlGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELE 177

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1039770402  499 AEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQ 549
Cdd:COG4942    178 ALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEAL 228
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
507-885 2.29e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 49.27  E-value: 2.29e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  507 ALTAHRDEIQRKFDAlrNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREM 586
Cdd:PRK02224   188 SLDQLKAQIEEKEEK--DLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREELETLEAEIEDLRE 265

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  587 QLTSqkqaqlsapDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQS 666
Cdd:PRK02224   266 TIAE---------TEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVA 336

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  667 -----------RARADQRITESRQVVELAvKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLE 735
Cdd:PRK02224   337 aqahneeaeslREDADDLEERAEELREEA-AELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLE 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  736 TERELKQRLLEEQAKLQQQMDLQKNHIfRLTQGLQEA---------------LDRADLLKTERSDLEYQLENIQVlyshE 800
Cdd:PRK02224   416 ELREERDELREREAELEATLRTARERV-EEAEALLEAgkcpecgqpvegsphVETIEEDRERVEELEAELEDLEE----E 490

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  801 KVKMEGTISQQTKLIDfLQAKMDQPAKKKKGLFSRRKEDPAlptqvplQYNELKLALEKEKARCAELEEALQKTRIELRS 880
Cdd:PRK02224   491 VEEVEERLERAEDLVE-AEDRIERLEERREDLEELIAERRE-------TIEEKRERAEELRERAAELEAEAEEKREAAAE 562


                   ....*
gi 1039770402  881 AREEA 885
Cdd:PRK02224   563 AEEEA 567
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 450-721 2.38e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.61  E-value: 2.38e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  450 EQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKteleettaeaeeeiQALTAHRDEIQrkfdalrnsctvi 529
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALE--------------RRIAALARRIR------------- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  530 tDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEivQLRSevdHLRREITEREMQLTSQKQAQLSAPDLQTMEALKT 609
Cdd:COG4942     73 -ALEQELAALEAELAELEKEIAELRAELEAQKEELAE--LLRA---LYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAP 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  610 TctmLEEQVLDLEALNDELLEKERQWEAWRsvlgdeksqfecrvRELQRMLDTEKQSRARADQRITESRQVvelaVKEHK 689
Cdd:COG4942    147 A---RREQAEELRADLAELAALRAELEAER--------------AELEALLAELEEERAALEALKAERQKL----LARLE 205

                          250       260       270
                   ....*....|....*....|....*....|..
gi 1039770402  690 AEILALQQALKEQKLKAESLSDKLNDLEKKHA 721
Cdd:COG4942    206 KELAELAAELAELQQEAEELEALIARLEAEAA 237
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 12-472 2.75e-05

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 48.97  E-value: 2.75e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   12 EMTRLHRRVSEVEAVLSQKEV---------ELKASETQRSLLE-----QDLATYIT---ECSSLKRSLEQARMEVSQEDD 74
Cdd:pfam05557    3 ELIESKARLSQLQNEKKQMELehkrarielEKKASALKRQLDResdrnQELQKRIRlleKREAEAEEALREQAELNRLKK 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   75 KALQLLHD-IREQSRKLQEIKE---------QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESrlaaeEFKRKA 144
Cdd:pfam05557   83 KYLEALNKkLNEKESQLADAREvisclknelSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEA-----EQLRQN 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  145 NECQHKLMKAKDQGKPEVGEYSKLEKINAEQQLKIQELQE---KLEKAVKASTEATELLQNIRQAKERAERELEKLHNRE 221
Cdd:pfam05557  158 LEKQQSSLAEAEQRIKELEFEIQSQEQDSEIVKNSKSELAripELEKELERLREHNKHLNENIENKLLLKEEVEDLKRKL 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  222 DSSEGIKKKLVEAEERRHSLENKVK---RLETMERRENRLKDDIQTKSEQIQQmadkilelEEKHREAQVSAqhlevhLK 298
Cdd:pfam05557  238 EREEKYREEAATLELEKEKLEQELQswvKLAQDTGLNLRSPEDLSRRIEQLQQ--------REIVLKEENSS------LT 303

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  299 QKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEkgkiLSEQKAMInamdSKIRSLEQRIVELSEANKLAANSS 378
Cdd:pfam05557  304 SSARQLEKARRELEQELAQYLKKIEDLNKKLKRHKALVRR----LQRRVLLL----TKERDGYRAILESYDKELTMSNYS 375

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  379 LFTQRNMKAQEEMI-------SELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQ-DHSDKSRLLELETRLREVSLEHEE 450
Cdd:pfam05557  376 PQLLERIEEAEDMTqkmqahnEEMEAQLSVAEEELGGYKQQAQTLERELQALRQQeSLADPSYSKEEVDSLRRKLETLEL 455

                          490       500
                   ....*....|....*....|..
gi 1039770402  451 QKLELKRQLTELQLSLQERESQ 472
Cdd:pfam05557  456 ERQRLREQKNELEMELERRCLQ 477
COG5281 COG5281
Phage-related minor tail protein [Mobilome: prophages, transposons];
340-776 3.13e-05

Phage-related minor tail protein [Mobilome: prophages, transposons];


Pssm-ID: 444092 [Multi-domain]  Cd Length: 603  Bit Score: 48.84  E-value: 3.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  340 GKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQ 419
Cdd:COG5281      3 ALAAAAALAAAAAAAAASAAAAAAAAALAAAAAAAAAAAGLAAAAAAAAAASLAAAAAAAALAAAAAAAAAAAAADALAA 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  420 LEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQlslQERESQLTALQAARAALESQLRQAKTELEETTA 499
Cdd:COG5281     83 ALAEDAAAAAAAAEAALAALAAAALALAAAALAEAALAAAAAAA---AAAAAAAAAAAAAAAAAAEAAKAAAAAAAAAAL 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  500 EAEEEIQALTAHRDEIQRKFDALRNSctvitDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRR 579
Cdd:COG5281    160 AAAAAAAAAAAAAAAAAAALAAASAA-----AAAAAAKAAAEAAAEAAAAAEAAAAAAAAAAEAAAAEAQALAAAALAEQ 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  580 EITEREMQLTSQKQAQLSapDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQfecRVRELQRM 659
Cdd:COG5281    235 AALAAASAAAQALAALAA--AAAAAALALAAAAELALTAQAEAAAAAAAAAAAAAQAAEAAAAAAEAQA---LAAAAAAA 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  660 LDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDlekkhAMLEMNARSLQQKLETERE 739
Cdd:COG5281    310 AAQLAAAAAAAAQALRAAAQALAALAQRALAAAALAAAAQEAALAAAAAALQAALE-----AAAAAAAAELAAAGDWAAG 384

                          410       420       430
                   ....*....|....*....|....*....|....*..
gi 1039770402  740 LKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRA 776
Cdd:COG5281    385 AKAALAEYADSATNVAAQVAQAATSAFSGLTDALAGA 421
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
166-521 3.18e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 48.36  E-value: 3.18e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  166 SKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNredssegikkklvEAEERRHSLENKV 245
Cdd:COG4372     27 AALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEE-------------ELEELNEQLQAAQ 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  246 KRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEqhyeEKIKVLDNQIKKDLADKESL 325
Cdd:COG4372     94 AELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAERE----EELKELEEQLESLQEELAAL 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  326 ENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQ 405
Cdd:COG4372    170 EQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKE 249

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  406 AGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALES 485
Cdd:COG4372    250 ELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLE 329

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1039770402  486 QLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDA 521
Cdd:COG4372    330 LALAILLAELADLLQLLLVGLLDNDVLELLSKGAEA 365
COG5022 COG5022
Myosin heavy chain [General function prediction only];
179-798 3.85e-05

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 48.54  E-value: 3.85e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  179 IQELQEKLEKavkasteatELLQNIRQAKERAERELEkLHNREDSSEGIKKKlVEAEERRHSLENKVKRLETMERRENRL 258
Cdd:COG5022    819 IIKLQKTIKR---------EKKLRETEEVEFSLKAEV-LIQKFGRSLKAKKR-FSLLKKETIYLQSAQRVELAERQLQEL 887

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  259 KDDIqtksEQIQQMADKILELEEKHREAQVSAQHLEV-HLKQKEQHYEEKIKVLDN-QIKKDLA-DKESLENMMQRHEEE 335
Cdd:COG5022    888 KIDV----KSISSLKLVNLELESEIIELKKSLSSDLIeNLEFKTELIARLKKLLNNiDLEEGPSiEYVKLPELNKLHEVE 963

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  336 A--HEKGKILSeqkAMINAMDSKIRSLEQRIVELSEANKLAAnsslftqrnmkaqeemisELRQQKFYLETQAGKLEAQN 413
Cdd:COG5022    964 SklKETSEEYE---DLLKKSTILVREGNKANSELKNFKKELA------------------ELSKQYGALQESTKQLKELP 1022

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  414 RKLEE--QLEKISHQDHSDKSRLLELEtrlrEVSLEHEEQKLELKRQLTELQLslqERESQLTalqaaraaLESQLRQAK 491
Cdd:COG5022   1023 VEVAElqSASKIISSESTELSILKPLQ----KLKGLLLLENNQLQARYKALKL---RRENSLL--------DDKQLYQLE 1087

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  492 TELEETTAEAEEEIQALTahrdeiqRKFDALRNSCTVITDLEEQLNqLTEDNAELNNQNFYLSKQLDEASGANDEIVQLR 571
Cdd:COG5022   1088 STENLLKTINVKDLEVTN-------RNLVKPANVLQFIVAQMIKLN-LLQEISKFLSQLVNTLEPVFQKLSVLQLELDGL 1159

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  572 SEVDHLRREITEREMQLTSQKQAQLSApdlqtmeALKTTCTMLEEQVLDLEalnDELLEKERQ-WEAWRSVLGDEKSQFE 650
Cdd:COG5022   1160 FWEANLEALPSPPPFAALSEKRLYQSA-------LYDEKSKLSSSEVNDLK---NELIALFSKiFSGWPRGDKLKKLISE 1229

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  651 CRVRELQRMLDTEKQSRAR--ADQRITESRQVVELAVKehkaeilaLQQALKEQKLKAESLSDKLNDLEKKHAM-----L 723
Cdd:COG5022   1230 GWVPTEYSTSLKGFNNLNKkfDTPASMSNEKLLSLLNS--------IDNLLSSYKLEEEVLPATINSLLQYINVglfnaL 1301

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039770402  724 EMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNhifrltqgLQEALDRADLLKTERSDLEYQLENIQVLYS 798
Cdd:COG5022   1302 RTKASSLRWKSATEVNYNSEELDDWCREFEISDVDEE--------LEELIQAVKVLQLLKDDLNKLDELLDACYS 1368
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 297-490 3.86e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 47.90  E-value: 3.86e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  297 LKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINA----MDSKIRSLEQRIVELSEANK 372
Cdd:COG3883     28 LQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEErreeLGERARALYRSGGSVSYLDV 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  373 LAANSSL--FTQRN------MKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEkishqdhsdksrllELETRLREV 444
Cdd:COG3883    108 LLGSESFsdFLDRLsalskiADADADLLEELKADKAELEAKKAELEAKLAELEALKA--------------ELEAAKAEL 173

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1039770402  445 slehEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQA 490
Cdd:COG3883    174 ----EAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAA 215
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 286-510 4.00e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 47.90  E-value: 4.00e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  286 AQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIV 365
Cdd:COG3883      3 ALALAAPTPAFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIE 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  366 ELSEA-NKLAA----NSSLFTQRNMKAQEEMISELRQQKFYLETQAgklEAQNRKLEEQLEkishqdhsDKSRLLELETR 440
Cdd:COG3883     83 ERREElGERARalyrSGGSVSYLDVLLGSESFSDFLDRLSALSKIA---DADADLLEELKA--------DKAELEAKKAE 151

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  441 LREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTA 510
Cdd:COG3883    152 LEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAA 221
mukB PRK04863
chromosome partition protein MukB;
254-770 4.23e-05

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 48.41  E-value: 4.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  254 RENRLKD---DIQTKSEQIQQMADKILELEEKHREA-QVSAQHLEVHLkqkEQHYEEKIKVLD---NQIKKDLADKESLE 326
Cdd:PRK04863   784 REKRIEQlraEREELAERYATLSFDVQKLQRLHQAFsRFIGSHLAVAF---EADPEAELRQLNrrrVELERALADHESQE 860

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  327 nmmQRHEEEAhekgKILSEQKAMINAMDSKIR-----SLEQRIVELSEANKLAANSSLFTQRNMKA-------------Q 388
Cdd:PRK04863   861 ---QQQRSQL----EQAKEGLSALNRLLPRLNlladeTLADRVEEIREQLDEAEEAKRFVQQHGNAlaqlepivsvlqsD 933

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  389 EEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLL----ELETRLREVSLEHEEQKLELKRQLTELQL 464
Cdd:PRK04863   934 PEQFEQLKQDYQQAQQTQRDAKQQAFALTEVVQRRAHFSYEDAAEMLaknsDLNEKLRQRLEQAEQERTRAREQLRQAQA 1013

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  465 SLQERESQLTALQAARAALESQLRQAKTELEET-TAEAEEEIQALTAHRDEIQrkfDALRNSCTVITDLEEQLnQLTEdn 543
Cdd:PRK04863  1014 QLAQYNQVLASLKSSYDAKRQMLQELKQELQDLgVPADSGAEERARARRDELH---ARLSANRSRRNQLEKQL-TFCE-- 1087

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  544 AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITER--EMQLTSQKQAQLSAPDLQTMeALKttctmleeqvlDL 621
Cdd:PRK04863  1088 AEMDNLTKKLRKLERDYHEMREQVVNAKAGWCAVLRLVKDNgvERRLHRRELAYLSADELRSM-SDK-----------AL 1155

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  622 EAL------NDELLEKERQWEAWRSVlgDEKSQFECRVRELQRmldtekqSRARADqrITESRQVVElavkehkaeilAL 695
Cdd:PRK04863  1156 GALrlavadNEHLRDVLRLSEDPKRP--ERKVQFYIAVYQHLR-------ERIRQD--IIRTDDPVE-----------AI 1213

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039770402  696 QQalkeqklkaesLSDKLNDLEKkhamlEMNARslQQKLETERElkqrllEEQAKLQQQMDLQKNHIFRLTQGLQ 770
Cdd:PRK04863  1214 EQ-----------MEIELSRLTE-----ELTSR--EQKLAISSE------SVANIIRKTIQREQNRIRMLNQGLQ 1264
C1_CeDKF1-like_rpt2 cd20798
second protein kinase C conserved region 1 (C1 domain) found in Caenorhabditis elegans serine ...
 954-1005 5.02e-05

second protein kinase C conserved region 1 (C1 domain) found in Caenorhabditis elegans serine/threonine-protein kinase DKF-1 and similar proteins; DKF-1 converts transient diacylglycerol (DAG) signals into prolonged physiological effects, independently of PKC. It plays a role in the regulation of growth and neuromuscular control of movement. It is involved in immune response to Staphylococcus aureus bacterium by activating transcription factor hlh-30 downstream of phospholipase plc-1. Members of this group contain two copies of the C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410348  Cd Length: 54  Bit Score: 42.49  E-value: 5.02e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039770402  954 PHRFNVGLNMRATKCAVClDTVHFG--RQASKCLECQVMCHPKCSTCLPATCGL 1005
Cdd:cd20798      1 PHTLAEHNYKKPTVCKVC-DKLLVGlvRQGLKCRDCGVNVHKKCASLLPSNCRL 53
PRK11281 PRK11281
mechanosensitive channel MscK;
441-767 5.13e-05

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 48.37  E-value: 5.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  441 LREVSLEHEEQKLeLKRQLTELQLSLQERESQ---LTALQAARAALESQLRQAKTEleettaeaeeeIQALTAHRDEIQR 517
Cdd:PRK11281    48 LNKQKLLEAEDKL-VQQDLEQTLALLDKIDRQkeeTEQLKQQLAQAPAKLRQAQAE-----------LEALKDDNDEETR 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  518 KfdalRNSCTVITDLEEQLNQLTEDNAELNNqnfylskqldEASGANDEIVQLRSEVDHLRREITE---REMQLTSQK-- 592
Cdd:PRK11281   116 E----TLSTLSLRQLESRLAQTLDQLQNAQN----------DLAEYNSQLVSLQTQPERAQAALYAnsqRLQQIRNLLkg 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  593 ----QAQLSAPDLQTMEAlkttctmleEQVLdLEALNDEllekERQWEAWRSVLGDeksqfecrVRELQRMLDTEKQsrA 668
Cdd:PRK11281   182 gkvgGKALRPSQRVLLQA---------EQAL-LNAQNDL----QRKSLEGNTQLQD--------LLQKQRDYLTARI--Q 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  669 RADQRITESRQVV---ELAVKEHKAEilALQQALKEQKLKAESLsdklndlekkhamlemnarsLQQKLETERELKQRLL 745
Cdd:PRK11281   238 RLEHQLQLLQEAInskRLTLSEKTVQ--EAQSQDEAARIQANPL--------------------VAQELEINLQLSQRLL 295

                          330       340
                   ....*....|....*....|....*
gi 1039770402  746 EEQAKLQQ--QMDLQ-KNHIFRLTQ 767
Cdd:PRK11281   296 KATEKLNTltQQNLRvKNWLDRLTQ 320
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 489-767 6.33e-05

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 47.11  E-value: 6.33e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  489 QAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANdEIV 568
Cdd:pfam15905   66 QKNLKESKDQKELEKEIRALVQERGEQDKRLQALEEE---LEKVEAKLNAAVREKTSLSASVASLEKQLLELTRVN-ELL 141

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  569 QLRSEVDHLRREITEREMQLT------SQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEawrsvl 642
Cdd:pfam15905  142 KAKFSEDGTQKKMSSLSMELMklrnklEAKMKEVMAKQEGMEGKLQVTQKNLEHSKGKVAQLEEKLVSTEKEKI------ 215

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  643 gDEKSQFECRVRELQRMldteKQSRARADQRITESRQVVELAvKEHKAEILALQQALKEqklKAESLSDKLNDLEKKHAM 722
Cdd:pfam15905  216 -EEKSETEKLLEYITEL----SCVSEQVEKYKLDIAQLEELL-KEKNDEIESLKQSLEE---KEQELSKQIKDLNEKCKL 286

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 1039770402  723 LEmnaRSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQ 767
Cdd:pfam15905  287 LE---SEKEELLREYEEKEQTLNAELEELKEKLTLEEQEHQKLQQ 328
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 241-422 6.85e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 47.13  E-value: 6.85e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  241 LENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIK---- 316
Cdd:COG3883     18 IQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARalyr 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  317 -----------------KDLADKESLENMMQRHEeeahekGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSL 379
Cdd:COG3883     98 sggsvsyldvllgsesfSDFLDRLSALSKIADAD------ADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKA 171

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1039770402  380 FTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEK 422
Cdd:COG3883    172 ELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAA 214
PH_ROCK cd01242
Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain; ROCK is ...
 1037-1082 7.00e-05

Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain; ROCK is a serine/threonine kinase that binds GTP-Rho. It consists of a kinase domain, a coiled coil region and a PH domain. The ROCK PH domain is interrupted by a C1 domain. ROCK plays a role in cellular functions, such as contraction, adhesion, migration, and proliferation and in the regulation of apoptosis. There are two ROCK isoforms, ROCK1 and ROCK2. In ROCK2 the Rho Binding Domain (RBD) and the PH domain work together in membrane localization with RBD receiving the RhoA signal and the PH domain receiving the phospholipid signal. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.


Pssm-ID: 269948  Cd Length: 110  Bit Score: 43.50  E-value: 7.00e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1039770402 1037 HLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPV 1082
Cdd:cd01242      2 RLEGWLSLPNKQNIRRHGWKKQYVVVSSKKILFYNSEQDKANSNPI 47
C1_aPKC cd20794
protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) ...
 956-1004 7.44e-05

protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) family; PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. They contain a C2-like region, instead of a calcium-binding (C2) region found in classical PKCs, in their regulatory domain. There are two aPKC isoforms, zeta and iota. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes. PKC-zeta plays a critical role in activating the glucose transport response. It is activated by glucose, insulin, and exercise through diverse pathways. PKC-zeta also plays a central role in maintaining cell polarity in yeast and mammalian cells. In addition, it affects actin remodeling in muscle cells. PKC-iota is directly implicated in carcinogenesis. It is critical to oncogenic signaling mediated by Ras and Bcr-Abl. The PKC-iota gene is the target of tumor-specific gene amplification in many human cancers, and has been identified as a human oncogene. In addition to its role in transformed growth, PKC-iota also promotes invasion, chemoresistance, and tumor cell survival. Expression profiling of PKC-iota is a prognostic marker of poor clinical outcome in several human cancers. PKC-iota also plays a role in establishing cell polarity, and has critical embryonic functions. Members of this family contain one C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410344  Cd Length: 55  Bit Score: 41.87  E-value: 7.44e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1039770402  956 RFNvglnmRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCG 1004
Cdd:cd20794      9 RFN-----RRAVCAYCSDRIwGLGRQGYKCINCKLLVHKKCHKLVKVACG 53
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 9-372 8.07e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 47.32  E-value: 8.07e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402    9 MEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSR 88
Cdd:TIGR04523  340 LNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQ 419

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   89 KLQEIkEQEYQaqveemrlmmNQLEEDLVSARRRSDLyESELRESRLAAEEFKRKANECQHKLMKAKDQGKpevGEYSKL 168
Cdd:TIGR04523  420 EKELL-EKEIE----------RLKETIIKNNSEIKDL-TNQDSVKELIIKNLDNTRESLETQLKVLSRSIN---KIKQNL 484

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  169 EKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERaERELEKLHNRedssegIKKKLVeaeerrhSLENKVKRL 248
Cdd:TIGR04523  485 EQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEK-IEKLESEKKE------KESKIS-------DLEDELNKD 550

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  249 ETMERRENrLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLE---VHLKQKEQHYEEKIKVLDNQI-------KKD 318
Cdd:TIGR04523  551 DFELKKEN-LEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEkekKDLIKEIEEKEKKISSLEKELekakkenEKL 629

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039770402  319 LADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANK 372
Cdd:TIGR04523  630 SSIIKNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIKESKTKIDDIIELMK 683
PH_MRCK cd01243
MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain; MRCK ...
 1039-1154 8.10e-05

MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain; MRCK is thought to be coincidence detector of signaling by Cdc42 and phosphoinositides. It has been shown to promote cytoskeletal reorganization, which affects many biological processes. There are 2 members of this family: MRCKalpha and MRCKbeta. MRCK consists of a serine/threonine kinase domain, a cysteine rich (C1) region, a PH domain and a p21 binding motif. The MRCK PH domain is responsible for its targeting to cell to cell junctions. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.


Pssm-ID: 269949  Cd Length: 135  Bit Score: 44.21  E-value: 8.10e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402 1039 EGWMKVPrnnKRG--QQGWDRKYIVLEGSKVLIYD-NEAREAGQRPVEEFELCLPDGDVSIhGAVGASELANTAKADVPY 1115
Cdd:cd01243     15 EGYVRVP---KPGgvKKGWQRQFAVVCDFKLFLFDiSEDKASQPSQVASQVLDMRDEEFSV-SSVLASDVIHANKKDIPC 90

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1039770402 1116 ILKME-SHPHTTCWPGRTLyLLAPSFPDKQRWVTALESVV 1154
Cdd:cd01243     91 IFRVSaSQLAPPSLKFSLL-MLADSENEKQKWVDALNELH 129
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 352-521 8.23e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 46.07  E-value: 8.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  352 AMDSKIRSLEQRIVELSEAnklaansslftqrnmkaqeemISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDK 431
Cdd:COG1579     14 ELDSELDRLEHRLKELPAE---------------------LAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVE 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  432 SRLLELETRLREVS-------LEHEEQKLELKRQLTELQLS-----LQERESQLTALQAARAALESQLRQAKTELEETTA 499
Cdd:COG1579     73 ARIKKYEEQLGNVRnnkeyeaLQKEIESLKRRISDLEDEILelmerIEELEEELAELEAELAELEAELEEKKAELDEELA 152

                          170       180
                   ....*....|....*....|..
gi 1039770402  500 EAEEEIQALTAHRDEIQRKFDA 521
Cdd:COG1579    153 ELEAELEELEAEREELAAKIPP 174
C1_Munc13-1 cd20858
protein kinase C conserved region 1 (C1 domain) found in Munc13-1 and similar proteins; ...
 953-1003 8.37e-05

protein kinase C conserved region 1 (C1 domain) found in Munc13-1 and similar proteins; Munc13-1, also called protein unc-13 homolog A (Unc13A), is a diacylglycerol (DAG) receptor that plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Loss of MUNC13-1 function causes microcephaly, cortical hyperexcitability, and fatal myasthenia. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410408  Cd Length: 60  Bit Score: 42.00  E-value: 8.37e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039770402  953 IPHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 1003
Cdd:cd20858      6 TPHNFEVWTATTPTYCYECEGLLwGIARQGMRCTECGVKCHEKCQDLLNADC 57
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
 258-667 9.19e-05

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 47.49  E-value: 9.19e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  258 LKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKikvldNQikkDLADKESLEnmmqrheeEAH 337
Cdd:PRK10246   424 LRQRLVALHGQIVPQQKRLAQLQVAIQNVTQEQTQRNAALNEMRQRYKEK-----TQ---QLADVKTIC--------EQE 487

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  338 EKGKILSEQKAMINAMDS--KIRSLEQRIVELSEANKLAANsslftQRNMKAQEEMISELRQQKFYLEtqaGKLEAqnrk 415
Cdd:PRK10246   488 ARIKDLEAQRAQLQAGQPcpLCGSTSHPAVEAYQALEPGVN-----QSRLDALEKEVKKLGEEGAALR---GQLDA---- 555

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  416 LEEQLekisHQDHSDKSRLLELETRLRE----------VSL-------------EHEEQKLELKRQLTELQLSLQERESQ 472
Cdd:PRK10246   556 LTKQL----QRDESEAQSLRQEEQALTQqwqavcaslnITLqpqddiqpwldaqEEHERQLRLLSQRHELQGQIAAHNQQ 631

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  473 LTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQR------KFDALRNSCTVITDLEEQLNQLTEDNAEL 546
Cdd:PRK10246   632 IIQYQQQIEQRQQQLLTALAGYALTLPQEDEEASWLATRQQEAQSwqqrqnELTALQNRIQQLTPLLETLPQSDDLPHSE 711

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  547 NnqnfylSKQLDEASGANDEIVQLRSEVDHLRREITErEMQLTSQKQAQLSApdlqtmeALKTTCtmLEEQVLDLEALND 626
Cdd:PRK10246   712 E------TVALDNWRQVHEQCLSLHSQLQTLQQQDVL-EAQRLQKAQAQFDT-------ALQASV--FDDQQAFLAALLD 775

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|.
gi 1039770402  627 EllEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSR 667
Cdd:PRK10246   776 E--ETLTQLEQLKQNLENQRQQAQTLVTQTAQALAQHQQHR 814
PRK12704 PRK12704
phosphodiesterase; Provisional
 141-309 1.03e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 46.69  E-value: 1.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  141 KRKANECQHKLMKAKDQGKPEVGEYSKLEKINAEQqlKIQELQEKLEKAVKAST-EATELLQNIRQAKERAERELEKLHN 219
Cdd:PRK12704    30 EAKIKEAEEEAKRILEEAKKEAEAIKKEALLEAKE--EIHKLRNEFEKELRERRnELQKLEKRLLQKEENLDRKLELLEK 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  220 REDssegikkklvEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQM----ADKILeLEEKHREAQVSAQHLev 295
Cdd:PRK12704   108 REE----------ELEKKEKELEQKQQELEKKEEELEELIEEQLQELERISGLtaeeAKEIL-LEKVEEEARHEAAVL-- 174

                          170
                   ....*....|....
gi 1039770402  296 hLKQKEQHYEEKIK 309
Cdd:PRK12704   175 -IKEIEEEAKEEAD 187
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 514-823 1.05e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 46.87  E-value: 1.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  514 EIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFY----LSKQLDEasgandEIVQLRSEVDHLRREITEREMQLT 589
Cdd:COG5185    233 EALKGFQDPESELEDLAQTSDKLEKLVEQNTDLRLEKLGenaeSSKRLNE------NANNLIKQFENTKEKIAEYTKSID 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  590 SQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQF--ECRVRELQRMLDTEKQSR 667
Cdd:COG5185    307 IKKATESLEEQLAAAEAEQELEESKRETETGIQNLTAEIEQGQESLTENLEAIKEEIENIvgEVELSKSSEELDSFKDTI 386

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  668 ARADQRITESRQVVELAVKEHKAeilALQQALKEQKLKAESLSDKLNDLEKKhamlemNARSLQQKLETERELKQRLLEE 747
Cdd:COG5185    387 ESTKESLDEIPQNQRGYAQEILA---TLEDTLKAADRQIEELQRQIEQATSS------NEEVSKLLNELISELNKVMREA 457

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770402  748 QAKLQQQMDLQKNHIFRltqGLQEALDRADLlktERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMD 823
Cdd:COG5185    458 DEESQSRLEEAYDEINR---SVRSKKEDLNE---ELTQIESRVSTLKATLEKLRAKLERQLEGVRSKLDQVAESLK 527
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 41-491 1.18e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 46.87  E-value: 1.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   41 RSLLEQDLATYITECSSLK---RSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQ-AQVEEMRLMMNQLEEDL 116
Cdd:COG5185    120 ISLLYLYKSEIVALKDELIkveKLDEIADIEASYGEVETGIIKDIFGKLTQELNQNLKKLEIfGLTLGLLKGISELKKAE 199

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  117 VSARRRSDLYESELRES------RLAAEEFKRKANEcqhKLMKAKDQGKPEVGEYS-KLEK-INAEQQLKIQELQEKLEK 188
Cdd:COG5185    200 PSGTVNSIKESETGNLGsestllEKAKEIINIEEAL---KGFQDPESELEDLAQTSdKLEKlVEQNTDLRLEKLGENAES 276

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  189 AVKASTEATELLQNIRQAKERAeRELEKLHNREDSSEGIKKKLVEAEERRHsLENKVKRLETMerrenrlkddIQTKSEQ 268
Cdd:COG5185    277 SKRLNENANNLIKQFENTKEKI-AEYTKSIDIKKATESLEEQLAAAEAEQE-LEESKRETETG----------IQNLTAE 344

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  269 IQQMADKILELEEKHREaQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQka 348
Cdd:COG5185    345 IEQGQESLTENLEAIKE-EIENIVGEVELSKSSEELDSFKDTIESTKESLDEIPQNQRGYAQEILATLEDTLKAADRQ-- 421

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  349 mINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLEtqagkLEAQNRKLEEQLEKIshqdh 428
Cdd:COG5185    422 -IEELQRQIEQATSSNEEVSKLLNELISELNKVMREADEESQSRLEEAYDEINRS-----VRSKKEDLNEELTQI----- 490

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039770402  429 sdKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQEREsqlTALQAARAALESQLRQAK 491
Cdd:COG5185    491 --ESRVSTLKATLEKLRAKLERQLEGVRSKLDQVAESLKDFM---RARGYAHILALENLIPAS 548
C1_nPKC_theta-like_rpt2 cd20837
second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) ...
 955-1003 1.19e-04

second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) theta, delta, and similar proteins; PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. PKC-theta is selectively expressed in T-cells and plays an important and non-redundant role in several aspects of T-cell biology. PKC-delta plays a role in cell cycle regulation and programmed cell death in many cell types. Members of this family contain two copies of C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410387  Cd Length: 50  Bit Score: 41.27  E-value: 1.19e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1039770402  955 HRFNVGLNMRATKCAVClDTVHFG--RQASKCLECQVMCHPKCSTCLPATC 1003
Cdd:cd20837      1 HRFKVYNYMSPTFCDHC-GSLLWGlfRQGLKCEECGMNVHHKCQKKVANLC 50
mukB PRK04863
chromosome partition protein MukB;
440-776 1.20e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 47.26  E-value: 1.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  440 RLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEEttaeaeeeIQALTAHRDEIQRKF 519
Cdd:PRK04863   283 VHLEEALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDYQAASDHLNL--------VQTALRQQEKIERYQ 354

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  520 DALrnsctviTDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEI------VQLRSEVDHLRREITEREMQLTSQKQ 593
Cdd:PRK04863   355 ADL-------EELEERLEEQNEVVEEADEQQEENEARAEAAEEEVDELksqladYQQALDVQQTRAIQYQQAVQALERAK 427

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  594 AQLSAPDLqTMEALKTtctMLEEQVLDLEALNDELLEKERQWeawrSVLGDEKSQFECRVRELQRMLDTEKQSRAR--AD 671
Cdd:PRK04863   428 QLCGLPDL-TADNAED---WLEEFQAKEQEATEELLSLEQKL----SVAQAAHSQFEQAYQLVRKIAGEVSRSEAWdvAR 499

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  672 QRITESRQVVELAVKEH--KAEILALQQALKEQKlKAESLsdkLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQA 749
Cdd:PRK04863   500 ELLRRLREQRHLAEQLQqlRMRLSELEQRLRQQQ-RAERL---LAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVS 575

                          330       340
                   ....*....|....*....|....*..
gi 1039770402  750 KLQQQMDLQKNHIFRLTQGLQEALDRA 776
Cdd:PRK04863   576 EARERRMALRQQLEQLQARIQRLAARA 602
PLN02939 PLN02939
transferase, transferring glycosyl groups
 2-245 1.24e-04

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 46.82  E-value: 1.24e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402    2 LLGEEAMMEQEMTRLHRRVSEVEA---VLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEqarMEVSQEDDKALQ 78
Cdd:PLN02939   161 ILTEKEALQGKINILEMRLSETDArikLAAQEKIHVEILEEQLEKLRNELLIRGATEGLCVHSLS---KELDVLKEENML 237

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   79 LLHDIREQSRKLQEIKE-QEYQAQVEEMRLMMNQLEEDLVSarRRSDLYESELRESRLAAEEFKRKANECQHKLMKAKDQ 157
Cdd:PLN02939   238 LKDDIQFLKAELIEVAEtEERVFKLEKERSLLDASLRELES--KFIVAQEDVSKLSPLQYDCWWEKVENLQDLLDRATNQ 315

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  158 gkpeVGEYSKLEKINAEQQLKIQELQEKLEKAV--KASTEATELLQN-IRQAKERAERELEKLHNR----EDSSEGIK-- 228
Cdd:PLN02939   316 ----VEKAALVLDQNQDLRDKVDKLEASLKEANvsKFSSYKVELLQQkLKLLEERLQASDHEIHSYiqlyQESIKEFQdt 391

                          250
                   ....*....|....*...
gi 1039770402  229 -KKLVEAEERRhSLENKV 245
Cdd:PLN02939   392 lSKLKEESKKR-SLEHPA 408
C1_aPKC_iota cd21094
protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) ...
 955-1006 1.37e-04

protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) iota type; PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. They contain a C2-like region, instead of a calcium-binding (C2) region found in classical PKCs, in their regulatory domain. There are two aPKC isoforms, zeta and iota. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes. PKC-iota is directly implicated in carcinogenesis. It is critical to oncogenic signaling mediated by Ras and Bcr-Abl. The PKC-iota gene is the target of tumor-specific gene amplification in many human cancers, and has been identified as a human oncogene. In addition to its role in transformed growth, PKC-iota also promotes invasion, chemoresistance, and tumor cell survival. Expression profiling of PKC-iota is a prognostic marker of poor clinical outcome in several human cancers. PKC-iota also plays a role in establishing cell polarity, and has critical embryonic functions. Members of this family contain C1 domain found in aPKC isoform iota. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410447  Cd Length: 55  Bit Score: 41.14  E-value: 1.37e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1039770402  955 HRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCGLP 1006
Cdd:cd21094      3 HTFQAKRFNRRAHCAICTDRIwGLGRQGYKCINCKLLVHKKCHKLVTIECGRH 55
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
653-907 1.38e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.83  E-value: 1.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  653 VRELqrMLDtEKQSRARAD------QRITESRQVVELAVKEHKA--EILALQQALKEQKLKAESLSDKLNDLEKKHAMLE 724
Cdd:COG4913    213 VREY--MLE-EPDTFEAADalvehfDDLERAHEALEDAREQIELlePIRELAERYAAARERLAELEYLRAALRLWFAQRR 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  725 MNArsLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEA-LDRADLLKTERSDLEYQLENIqvlyshekvk 803
Cdd:COG4913    290 LEL--LEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNgGDRLEQLEREIERLERELEER---------- 357

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  804 mEGTISQQTKLIDFLQAKMDQPAKkkkGLFSRRKEDPALPTQVPLQYNELKLALekekarcAELEEALQKTRIELRSARE 883
Cdd:COG4913    358 -ERRRARLEALLAALGLPLPASAE---EFAALRAEAAALLEALEEELEALEEAL-------AEAEAALRDLRRELRELEA 426

                          250       260
                   ....*....|....*....|....
gi 1039770402  884 EAAHRKATDHPHPSTPATARQQIA 907
Cdd:COG4913    427 EIASLERRKSNIPARLLALRDALA 450
PRK09039 PRK09039
peptidoglycan -binding protein;
577-714 1.53e-04

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 45.73  E-value: 1.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  577 LRREITEREMQLtSQKQAQLSapDLQTMEAL-KTTCTMLEEQVLDLEA-LNDELLEKERqWEAWRSVLGDEKSQFECRVR 654
Cdd:PRK09039    44 LSREISGKDSAL-DRLNSQIA--ELADLLSLeRQGNQDLQDSVANLRAsLSAAEAERSR-LQALLAELAGAGAAAEGRAG 119

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770402  655 ELQRMLDTEKQSRARADQRITE-SRQVVELavkehKAEILALQQAL-------KEQKLKAESLSDKLN 714
Cdd:PRK09039   120 ELAQELDSEKQVSARALAQVELlNQQIAAL-----RRQLAALEAALdasekrdRESQAKIADLGRRLN 182
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 173-477 1.75e-04

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 45.57  E-value: 1.75e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  173 AEQQLKIQELQEKLEKAVKASTEATELLQNIR-QAKERAERElEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETM 251
Cdd:pfam15905   52 TARKVKSLELKKKSQKNLKESKDQKELEKEIRaLVQERGEQD-KRLQALEEELEKVEAKLNAAVREKTSLSASVASLEKQ 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  252 ERRENRLKDDIQTK-SEQIQQMADKILELEekhreaqVSAQHLEVHLKQKEqhyeekikVLDNQIKKDLADKESLENMMQ 330
Cdd:pfam15905  131 LLELTRVNELLKAKfSEDGTQKKMSSLSME-------LMKLRNKLEAKMKE--------VMAKQEGMEGKLQVTQKNLEH 195

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  331 RHEEEAHEKGKILSEQKAMINAmDSKIRSLEQRIVELSEANKLAANSSLftqrnmkaqeemisELRQQKFYLETQAGKLE 410
Cdd:pfam15905  196 SKGKVAQLEEKLVSTEKEKIEE-KSETEKLLEYITELSCVSEQVEKYKL--------------DIAQLEELLKEKNDEIE 260

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039770402  411 AQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQ 477
Cdd:pfam15905  261 SLKQSLEEKEQELSKQIKDLNEKCKLLESEKEELLREYEEKEQTLNAELEELKEKLTLEEQEHQKLQ 327
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 198-536 1.80e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 46.04  E-value: 1.80e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  198 ELLQNIRQAKERAERELEKLHnrEDSSEGIKKKLVEAEERRHSLENKVKRLETmerrenrlkdDIQTKSEQIQQMADKIL 277
Cdd:pfam07888   30 ELLQNRLEECLQERAELLQAQ--EAANRQREKEKERYKRDREQWERQRRELES----------RVAELKEELRQSREKHE 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  278 ELEEKHREAQVS----AQHLEVHLKQKEQH------YEEKIKVLD---------------------NQIKKDLADKESLE 326
Cdd:pfam07888   98 ELEEKYKELSASseelSEEKDALLAQRAAHearireLEEDIKTLTqrvleretelermkerakkagAQRKEEEAERKQLQ 177

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  327 NMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSeaNKLAAnsslfTQRNMKAQEEMISELRQQKFYLETQA 406
Cdd:pfam07888  178 AKLQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLT--QKLTT-----AHRKEAENEALLEELRSLQERLNASE 250

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  407 GKLEAQNRKLEEQlekISHQDHS----DKSRL--LELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAAR 480
Cdd:pfam07888  251 RKVEGLGEELSSM---AAQRDRTqaelHQARLqaAQLTLQLADASLALREGRARWAQERETLQQSAEADKDRIEKLSAEL 327

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770402  481 AALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQL 536
Cdd:pfam07888  328 QRLEERLQEERMEREKLEVELGREKDCNRVQLSESRRELQELKASLRVAQKEKEQL 383
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 671-828 1.83e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 44.92  E-value: 1.83e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  671 DQRITESRQvvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLEterELKQRLLE---- 746
Cdd:COG1579     16 DSELDRLEH----RLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIK---KYEEQLGNvrnn 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  747 -EQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQP 825
Cdd:COG1579     89 kEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREEL 168


                   ...
gi 1039770402  826 AKK 828
Cdd:COG1579    169 AAK 171
C1_MTMR-like cd20828
protein kinase C conserved region 1 (C1 domain) found in uncharacterized proteins similar to ...
 951-1004 1.95e-04

protein kinase C conserved region 1 (C1 domain) found in uncharacterized proteins similar to myotubularin-related proteins; The family includes a group of uncharacterized proteins that show high sequence similarity to vertebrate myotubularin-related proteins (MTMRs), such as MTMR5 and MTMR13. MTMRs may function as guanine nucleotide exchange factors (GEFs). Vertebrate MTMR5 and MTMR13 contain an N-terminal DENN domain, a PH-GRAM domain, an inactive PTP domain, a SET interaction domain, a coiled-coil domain, and a C-terminal PH domain. Members of this family contain these domains and have an additional C1 domain. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410378  Cd Length: 57  Bit Score: 40.89  E-value: 1.95e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1039770402  951 HNIPHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCG 1004
Cdd:cd20828      2 FTQPHNFEPHSFVTPTNCDYCLQILwGIVKKGMKCSECGYNCHEKCQPQVPKQCS 56
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 10-213 2.33e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 46.21  E-value: 2.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   10 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRK 89
Cdd:TIGR02169  818 EQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQ 897

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   90 L--QEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRE------SRLAAEEFKRKANECQHKLMKAKDQGKPE 161
Cdd:TIGR02169  898 LreLERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEdeeipeEELSLEDVQAELQRVEEEIRALEPVNMLA 977

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039770402  162 VGEYsklekinAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERE 213
Cdd:TIGR02169  978 IQEY-------EEVLKRLDELKEKRAKLEEERKAILERIEEYEKKKREVFME 1022
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 183-477 2.35e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 45.88  E-value: 2.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  183 QEKLEKAVKasteatellQNIRQAKERAERELEKlhnredssegiKKKLVEAEERRHSlenKVKRLETMERRENRLKDDI 262
Cdd:pfam17380  290 QEKFEKMEQ---------ERLRQEKEEKAREVER-----------RRKLEEAEKARQA---EMDRQAAIYAEQERMAMER 346

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  263 QTKSEQIQQmadkilelEEKHREAQvsaqhlevHLKQKEQHYE-EKIKVLDNqikkdLADKESLENMMQRHEEEAHEKGK 341
Cdd:pfam17380  347 ERELERIRQ--------EERKRELE--------RIRQEEIAMEiSRMRELER-----LQMERQQKNERVRQELEAARKVK 405

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  342 ILSEQKAminamdskiRSLEQRIVELSEANKLAANSSlftQRNMKAQEEMISElrqqkfylETQAGKLEAQNRklEEQLE 421
Cdd:pfam17380  406 ILEEERQ---------RKIQQQKVEMEQIRAEQEEAR---QREVRRLEEERAR--------EMERVRLEEQER--QQQVE 463

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770402  422 KISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQ 477
Cdd:pfam17380  464 RLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKLLE 519
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 563-756 2.52e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.21  E-value: 2.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  563 ANDEIVQLRSEVDHLRREITEREMQLtSQKQAQLSapdlQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVL 642
Cdd:COG3883     14 ADPQIQAKQKELSELQAELEAAQAEL-DALQAELE----ELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREEL 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  643 GDeksqfecRVRELQR------MLDTEKQSRARAD--QRITESRQVVElavkeHKAEILALQQALKEQ-KLKAESLSDKL 713
Cdd:COG3883     89 GE-------RARALYRsggsvsYLDVLLGSESFSDflDRLSALSKIAD-----ADADLLEELKADKAElEAKKAELEAKL 156

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1039770402  714 NDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMD 756
Cdd:COG3883    157 AELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLA 199
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 203-356 2.55e-04

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 45.97  E-value: 2.55e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  203 IRQAKERAERELEKLhnrEDSSEGIKKKLVEAEERRHSLENKVKRLEtmerrenRLKDDIQTKSEQIQQMADKIL-ELEE 281
Cdd:PRK00409   504 IEEAKKLIGEDKEKL---NELIASLEELERELEQKAEEAEALLKEAE-------KLKEELEEKKEKLQEEEDKLLeEAEK 573

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  282 KHREA-------------QVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKdlADKESLENMMQRHEEEAHEKGKILS-EQK 347
Cdd:PRK00409   574 EAQQAikeakkeadeiikELRQLQKGGYASVKAHELIEARKRLNKANEK--KEKKKKKQKEKQEELKVGDEVKYLSlGQK 651


                   ....*....
gi 1039770402  348 AMINAMDSK 356
Cdd:PRK00409   652 GEVLSIPDD 660
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 52-372 2.57e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 46.20  E-value: 2.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   52 ITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSrKLQEIKEQEYQA----QVEEMRLMMNQLEEDLVSARRRSDLYE 127
Cdd:TIGR01612 1364 IDEVKEYTKEIEENNKNIKDELDKSEKLIKKIKDDI-NLEECKSKIESTlddkDIDECIKKIKELKNHILSEESNIDTYF 1442

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  128 SELRESR----LAAEEFKRKANECQHKLMKAKDQGkpevgeysklekiNAEQQLKIQELQEKLEKAVKASTEATELLQNI 203
Cdd:TIGR01612 1443 KNADENNenvlLLFKNIEMADNKSQHILKIKKDNA-------------TNDHDFNINELKEHIDKSKGCKDEADKNAKAI 1509

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  204 RQAK---ERAERELEKLHNREDSSEgIKKKLVEAEERRHSLENKVKRL--------ETMERRENRLKD------------ 260
Cdd:TIGR01612 1510 EKNKelfEQYKKDVTELLNKYSALA-IKNKFAKTKKDSEIIIKEIKDAhkkfileaEKSEQKIKEIKKekfrieddaakn 1588

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  261 --------DIQTKSEQIQQMADKILELEEKHREAqvsaqhlevhLKQKEQhYEEKIKVLD-NQIKKDLADKESLENMMQR 331
Cdd:TIGR01612 1589 dksnkaaiDIQLSLENFENKFLKISDIKKKINDC----------LKETES-IEKKISSFSiDSQDTELKENGDNLNSLQE 1657

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770402  332 HEEEAHEKGKILSEQKAMINAMDSKIRSLE---------------QRIVELSEANK 372
Cdd:TIGR01612 1658 FLESLKDQKKNIEDKKKELDELDSEIEKIEidvdqhkknyeigiiEKIKEIAIANK 1713
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 172-844 2.81e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 45.81  E-value: 2.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  172 NAEQQLKIQELQEKLEKAVKAsteatelLQNIrqakeraERELEKLH--NREDSSEGIKKKLVEAEERRHSLENKV--KR 247
Cdd:TIGR01612  691 NTEDKAKLDDLKSKIDKEYDK-------IQNM-------ETATVELHlsNIENKKNELLDIIVEIKKHIHGEINKDlnKI 756

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  248 LETMERRENRLKDDIQTKS---EQIQQMADKILELEEKHREaQVSAQHL-EVHLKQ---KEQHYEEKIKVLDNQIKKDLA 320
Cdd:TIGR01612  757 LEDFKNKEKELSNKINDYAkekDELNKYKSKISEIKNHYND-QINIDNIkDEDAKQnydKSKEYIKTISIKEDEIFKIIN 835

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  321 D----KESLENMMQRHEE-EAHEKGKILSEQKA---MINAMDSKIRSLEQRIVElseaNKLAANSSLFTQRNMKAQEEM- 391
Cdd:TIGR01612  836 EmkfmKDDFLNKVDKFINfENNCKEKIDSEHEQfaeLTNKIKAEISDDKLNDYE----KKFNDSKSLINEINKSIEEEYq 911

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  392 -ISELRQQKFYLETQAGKLEA----------QNRKLEEQLEKISHQDHSDKSRLLELETRLrevslehEEQKLELKRQLT 460
Cdd:TIGR01612  912 nINTLKKVDEYIKICENTKESiekfhnkqniLKEILNKNIDTIKESNLIEKSYKDKFDNTL-------IDKINELDKAFK 984

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  461 ELqlSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEiqaltAHRDEIQRKFDALRNSC-------TVITDLE 533
Cdd:TIGR01612  985 DA--SLNDYEAKNNELIKYFNDLKANLGKNKENMLYHQFDEKEK-----ATNDIEQKIEDANKNIPnieiaihTSIYNII 1057

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  534 EQLNQLTEDNAELNNQNFYLS-----------------------------KQLDEASGANDEIVQLRSEVDHLRREITEr 584
Cdd:TIGR01612 1058 DEIEKEIGKNIELLNKEILEEaeinitnfneikeklkhynfddfgkeeniKYADEINKIKDDIKNLDQKIDHHIKALEE- 1136

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  585 emqltSQKQAQlsapdlQTMEALKTTCTMLEEqVLDLEALNDELLEKERQWEAWRSVLGDEKSQFEcrvrELQRMLDteK 664
Cdd:TIGR01612 1137 -----IKKKSE------NYIDEIKAQINDLED-VADKAISNDDPEEIEKKIENIVTKIDKKKNIYD----EIKKLLN--E 1198

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  665 QSRARADQRITESRQVVELAVKEHKAEiLALQQaLKEQKLKAE----SLSDKLNDLE--KKHAMLEMNARSLQQKLETER 738
Cdd:TIGR01612 1199 IAEIEKDKTSLEEVKGINLSYGKNLGK-LFLEK-IDEEKKKSEhmikAMEAYIEDLDeiKEKSPEIENEMGIEMDIKAEM 1276

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  739 EL--------KQRLLEEQAKLQQQMDLqKNHIFRLTQGLQEALDRADLLKT----------ERSDLEYQLENIQVLYSHE 800
Cdd:TIGR01612 1277 ETfnishdddKDHHIISKKHDENISDI-REKSLKIIEDFSEESDINDIKKElqknlldaqkHNSDINLYLNEIANIYNIL 1355

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*...
gi 1039770402  801 KV----KMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPT 844
Cdd:TIGR01612 1356 KLnkikKIIDEVKEYTKEIEENNKNIKDELDKSEKLIKKIKDDINLEE 1403
C1_PKD2_rpt2 cd20843
second protein kinase C conserved region 1 (C1 domain) found in protein kinase D2 (PKD2) and ...
 953-1003 2.83e-04

second protein kinase C conserved region 1 (C1 domain) found in protein kinase D2 (PKD2) and similar proteins; PKD2, also called PRKD2, HSPC187, or serine/threonine-protein kinase D2 (nPKC-D2), is a serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. PKD2 contains N-terminal tandem cysteine-rich zinc binding C1 (PKC conserved region 1), central PH (Pleckstrin Homology), and C-terminal catalytic kinase domains. This model corresponds to the second C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410393  Cd Length: 79  Bit Score: 41.11  E-value: 2.83e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039770402  953 IPHRFNVGLNMRATKCAVCLDTVH-FGRQASKCLECQVMCHPKCSTCLPATC 1003
Cdd:cd20843     10 VPHTFVIHSYTRPTVCQFCKKLLKgLFRQGLQCKDCKFNCHKRCATRVPNDC 61
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 164-341 2.98e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 45.14  E-value: 2.98e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  164 EYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERR----- 238
Cdd:COG4942     35 EIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELlraly 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  239 --------------HSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHY 304
Cdd:COG4942    115 rlgrqpplalllspEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALK 194

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 1039770402  305 EEKIKVLD----------NQIKKDLADKESLENMMQRHEEEAHEKGK 341
Cdd:COG4942    195 AERQKLLArlekelaelaAELAELQQEAEELEALIARLEAEAAAAAE 241
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 388-789 3.14e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 45.50  E-value: 3.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  388 QEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELEtRLREVSLEHEEQKLELKRQLTELQLSLQ 467
Cdd:pfam17380  280 HQKAVSERQQQEKFEKMEQERLRQEKEEKAREVERRRKLEEAEKARQAEMD-RQAAIYAEQERMAMERERELERIRQEER 358

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  468 ERESQltalqaaraalesQLRQakteleettaeaeeeiqaltahrDEIQRKFDALRnsctvitdleeqlnQLTEDNAELN 547
Cdd:pfam17380  359 KRELE-------------RIRQ-----------------------EEIAMEISRMR--------------ELERLQMERQ 388

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  548 NQNFYLSKQLDEASGandeiVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEalkttctmlEEQVLDLEALNDE 627
Cdd:pfam17380  389 QKNERVRQELEAARK-----VKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLE---------EERAREMERVRLE 454

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  628 LLEKERQWEAWRsvlgdeksQFECRVRELQRMLDTEKQSRARADQritESRQVVELAVKEHKaeilalqQALKEQKLKAE 707
Cdd:pfam17380  455 EQERQQQVERLR--------QQEEERKRKKLELEKEKRDRKRAEE---QRRKILEKELEERK-------QAMIEEERKRK 516

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  708 SLSDKLNdlEKKHAMLEMNARslqQKLETERElKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLE 787
Cdd:pfam17380  517 LLEKEME--ERQKAIYEEERR---REAEEERR-KQQEMEERRRIQEQMRKATEERSRLEAMEREREMMRQIVESEKARAE 590


                   ..
gi 1039770402  788 YQ 789
Cdd:pfam17380  591 YE 592
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
552-796 3.33e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 45.39  E-value: 3.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  552 YLSKQLDEASGANDEIVQ-LRSEVDHLRREITEREMQLTS-QKQAQLSAPDLQTMEALKTTcTMLEEQVLDLEAlndELL 629
Cdd:COG3206    161 YLEQNLELRREEARKALEfLEEQLPELRKELEEAEAALEEfRQKNGLVDLSEEAKLLLQQL-SELESQLAEARA---ELA 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  630 EKERQWEAWRSVLGDEKSQF-----ECRVRELQRMLDTEKQSRARADQRITE-SRQVVELavkehKAEILALQQALKEQK 703
Cdd:COG3206    237 EAEARLAALRAQLGSGPDALpellqSPVIQQLRAQLAELEAELAELSARYTPnHPDVIAL-----RAQIAALRAQLQQEA 311

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  704 LKAeslsdkLNDLEKKHAMLEMNARSLQQKLEterELKQRLLEEQAKLQQQMDLQKNhIFRLTQGLQEALDRADLLKTER 783
Cdd:COG3206    312 QRI------LASLEAELEALQAREASLQAQLA---QLEARLAELPELEAELRRLERE-VEVARELYESLLQRLEEARLAE 381

                          250
                   ....*....|...
gi 1039770402  784 SdleYQLENIQVL 796
Cdd:COG3206    382 A---LTVGNVRVI 391
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 11-330 4.08e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 45.01  E-value: 4.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   11 QEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKL 90
Cdd:TIGR04523  433 ETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKV 512

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   91 QEIKEQ--EYQAQVEEMRLMMNQLEEDLvsarrrSDLyESELRE--SRLAAEEFKRKANECQHKLMKAKDqgkpevgEYS 166
Cdd:TIGR04523  513 KDLTKKisSLKEKIEKLESEKKEKESKI------SDL-EDELNKddFELKKENLEKEIDEKNKEIEELKQ-------TQK 578

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  167 KLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVK 246
Cdd:TIGR04523  579 SLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIR 658

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  247 rlETMERRENRLKDDIQTKSEQIQQMADKILELeEKHREAQVSAQHLEVHLKQKEQHYEEkikvldnqIKKDLAD----K 322
Cdd:TIGR04523  659 --NKWPEIIKKIKESKTKIDDIIELMKDWLKEL-SLHYKKYITRMIRIKDLPKLEEKYKE--------IEKELKKldefS 727


                   ....*...
gi 1039770402  323 ESLENMMQ 330
Cdd:TIGR04523  728 KELENIIK 735
C1_Munc13-2-like cd20859
protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar ...
 949-1003 4.16e-04

protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins; Munc13-2, also called protein unc-13 homolog B (Unc13B), plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Munc13-2 is essential for normal release probability at hippocampal mossy fiber synapses. Munc13-3 is almost exclusively expressed in the cerebellum. It acts as a tumor suppressor and plays a critical role in the formation of release sites with calcium channel nanodomains. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410409  Cd Length: 82  Bit Score: 40.82  E-value: 4.16e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770402  949 MHHNIPHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 1003
Cdd:cd20859     14 ISCTTPHNFEVWTATTPTYCYECEGLLwGIARQGMRCSECGVKCHEKCQDLLNADC 69
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 59-222 4.26e-04

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 44.94  E-value: 4.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   59 KRSLEQARMEVSQEDDKALQllHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLV----SARRRSDLYESELRESR 134
Cdd:pfam15709  345 MRRLEVERKRREQEEQRRLQ--QEQLERAEKMREELELEQQRRFEEIRLRKQRLEEERQrqeeEERKQRLQLQAAQERAR 422

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  135 LAAEEFKRKANECQHKlmkaKDQGKPEVGEYSKLEKINAEQQLKiqELQEKLekAVKASTEATELLQNIRQAKERAEREL 214
Cdd:pfam15709  423 QQQEEFRRKLQELQRK----KQQEEAERAEAEKQRQKELEMQLA--EEQKRL--MEMAEEERLEYQRQKQEAEEKARLEA 494


                   ....*...
gi 1039770402  215 EKLHNRED 222
Cdd:pfam15709  495 EERRQKEE 502
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
249-489 4.40e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 45.01  E-value: 4.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  249 ETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQvsAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENM 328
Cdd:COG3206    164 QNLELRREEARKALEFLEEQLPELRKELEEAEAALEEFR--QKNGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEAR 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  329 MQRHEEEAHEKGKILSEQKAminamDSKIRSLEQRIVELSEanKLAANSSLFTQRN--MKAQEEMISELRQQkfyletqa 406
Cdd:COG3206    242 LAALRAQLGSGPDALPELLQ-----SPVIQQLRAQLAELEA--ELAELSARYTPNHpdVIALRAQIAALRAQ-------- 306

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  407 gkLEAQNRKLEEQLEkishqdhsdkSRLLELETRLREVSLEHEEQKLELKRqltelqlsLQERESQLTALQAARAALESQ 486
Cdd:COG3206    307 --LQQEAQRILASLE----------AELEALQAREASLQAQLAQLEARLAE--------LPELEAELRRLEREVEVAREL 366


                   ...
gi 1039770402  487 LRQ 489
Cdd:COG3206    367 YES 369
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 18-486 5.06e-04

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 44.74  E-value: 5.06e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   18 RRVSEV-EAVLSQKEVELKasETQRSLLEQDLATYITECSSLKRSL-EQARMEVSQ-----EDDKALQLLHDIREQSRKL 90
Cdd:pfam07111  184 KRAGEAkQLAEAQKEAELL--RKQLSKTQEELEAQVTLVESLRKYVgEQVPPEVHSqtwelERQELLDTMQHLQEDRADL 261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   91 QEIKEQeYQAQVEEMRLMMNQLEEDLVSARRRSDLYESEL-RESRLAAEEFKRKANECQHKLmKAKDqgkpevgeyskLE 169
Cdd:pfam07111  262 QATVEL-LQVRVQSLTHMLALQEEELTRKIQPSDSLEPEFpKKCRSLLNRWREKVFALMVQL-KAQD-----------LE 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  170 KINAEQQLKIQ--ELQEKlekaVKASTEATELLQNIRQAKErAERELEKLhnredSSEGIKKKLVEAEERRHSLENKVKR 247
Cdd:pfam07111  329 HRDSVKQLRGQvaELQEQ----VTSQSQEQAILQRALQDKA-AEVEVERM-----SAKGLQMELSRAQEARRRQQQQTAS 398

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  248 LETMER----RENRLKDDIQTKSEQIQQMADKILELEEK--------HREAQVSAQHLEV-HLKQKEQHYEEKIKVLDNQ 314
Cdd:pfam07111  399 AEEQLKfvvnAMSSTQIWLETTMTRVEQAVARIPSLSNRlsyavrkvHTIKGLMARKVALaQLRQESCPPPPPAPPVDAD 478

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  315 IKKDLadkESLENMMQRHEEEAHEKGKILSEQKAminamdskiRSLEQRIVELSEANKLAANsslFTQRNMKAQEEMISE 394
Cdd:pfam07111  479 LSLEL---EQLREERNRLDAELQLSAHLIQQEVG---------RAREQGEAERQQLSEVAQQ---LEQELQRAQESLASV 543

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  395 LRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSL-------- 466
Cdd:pfam07111  544 GQQLEVARQGQQESTEEAASLRQELTQQQEIYGQALQEKVAEVETRLREQLSDTKRRLNEARREQAKAVVSLrqiqhrat 623

                          490       500
                   ....*....|....*....|..
gi 1039770402  467 --QERESQLTALQAARAALESQ 486
Cdd:pfam07111  624 qeKERNQELRRLQDEARKEEGQ 645
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 527-755 5.49e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.44  E-value: 5.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  527 TVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASG----ANDEIVQLRSEVDHLRREITEREMQLtSQKQAQLSApDLQ 602
Cdd:COG3883     16 PQIQAKQKELSELQAELEAAQAELDALQAELEELNEeyneLQAELEALQAEIDKLQAEIAEAEAEI-EERREELGE-RAR 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  603 TMEALKTTCTMLEeQVLDLEALNDELlekeRQWEAWRSVLGDEKSQFEcRVRELQRMLDTEKQSRARADQRITESRQVVE 682
Cdd:COG3883     94 ALYRSGGSVSYLD-VLLGSESFSDFL----DRLSALSKIADADADLLE-ELKADKAELEAKKAELEAKLAELEALKAELE 167

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039770402  683 LAVKEhkaeilaLQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQM 755
Cdd:COG3883    168 AAKAE-------LEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAA 233
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 99-441 5.49e-04

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 44.78  E-value: 5.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   99 QAQVEEMRLMMNQLEEDLVS---ARRRSDL--------YESELRESRLAAEEFKRKAN----ECQHKLMKAKDQGKPEVG 163
Cdd:pfam01576  691 EQQVEEMKTQLEELEDELQAtedAKLRLEVnmqalkaqFERDLQARDEQGEEKRRQLVkqvrELEAELEDERKQRAQAVA 770

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  164 EYSKLEkinaeqqLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKklvEAEERRHSLEN 243
Cdd:pfam01576  771 AKKKLE-------LDLKELEAQIDAANKGREEAVKQLKKLQAQMKDLQRELEEARASRDEILAQSK---ESEKKLKNLEA 840

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  244 KVKRLETMERRENRLKDDIQTKSEQIQ------------------QMADKILELEEKHREAQVSAQHLEVHLKQKEQHYE 305
Cdd:pfam01576  841 ELLQLQEDLAASERARRQAQQERDELAdeiasgasgksalqdekrRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVE 920

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  306 EkikvLDNQIKKDLADKESLENMMQRHEEEAHE--------KGKILSEQKAMINAMDSKIRSLEQRIVElsEANKLAANS 377
Cdd:pfam01576  921 Q----LTTELAAERSTSQKSESARQQLERQNKElkaklqemEGTVKSKFKSSIAALEAKIAQLEEQLEQ--ESRERQAAN 994

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  378 SLFTQRNMKAQEEMI--------------------SELRQQKFYL---ETQAGKLEAQNRKLEEQLEKISHQDHSDKSRL 434
Cdd:pfam01576  995 KLVRRTEKKLKEVLLqvederrhadqykdqaekgnSRMKQLKRQLeeaEEEASRANAARRKLQRELDDATESNESMNREV 1074


                   ....*..
gi 1039770402  435 LELETRL 441
Cdd:pfam01576 1075 STLKSKL 1081
46 PHA02562
endonuclease subunit; Provisional
 83-317 6.77e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 44.23  E-value: 6.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   83 IREQSrklQEIKEQEYQAQVEEMRLMM---NQLEEDLVSARRRSDL---YESELREsrlaAEEFKRKANECQHKLMK-AK 155
Cdd:PHA02562   176 IRELN---QQIQTLDMKIDHIQQQIKTynkNIEEQRKKNGENIARKqnkYDELVEE----AKTIKAEIEELTDELLNlVM 248

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  156 DQGKPEvgeySKLEKINAEQ---QLKIQELQeKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLV 232
Cdd:PHA02562   249 DIEDPS----AALNKLNTAAakiKSKIEQFQ-KVIKMYEKGGVCPTCTQQISEGPDRITKIKDKLKELQHSLEKLDTAID 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  233 EAEERRHSLENKVKRLetmerreNRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLD 312
Cdd:PHA02562   324 ELEEIMDEFNEQSKKL-------LELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKLQDELDKIVKTKS 396


                   ....*
gi 1039770402  313 NQIKK 317
Cdd:PHA02562   397 ELVKE 401
C1_dGM13116p-like cd20831
protein kinase C conserved region 1 (C1 domain) found in Drosophila melanogaster GM13116p and ...
 966-1003 6.85e-04

protein kinase C conserved region 1 (C1 domain) found in Drosophila melanogaster GM13116p and similar proteins; This group contains uncharacterized proteins including Drosophila melanogaster GM13116p and Caenorhabditis elegans hypothetical protein R11G1.4, both of which contain C2 (a calcium-binding domain) and C1 domains. This model describes the C1 domain, a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410381  Cd Length: 58  Bit Score: 39.25  E-value: 6.85e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039770402  966 TKCAVCLDTV--HFGRQASKCLECQVMCHPKCSTCLPATC 1003
Cdd:cd20831     17 PSCAVCNKLIpgRFGKQGYQCRDCGLICHKRCHVKVETHC 56
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 460-790 7.22e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 44.12  E-value: 7.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  460 TELQLSLQERESQLTALQAARAALESQLRQAKTEleettaeaeeeiqaltahRDEIQRKFDALRNSctvITDLEEQLNQL 539
Cdd:pfam07888   34 NRLEECLQERAELLQAQEAANRQREKEKERYKRD------------------REQWERQRRELESR---VAELKEELRQS 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  540 TEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTCTMLEEQV- 618
Cdd:pfam07888   93 REKHEELEEKYKELSASSEELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAe 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  619 -----LDLEALNDELLEKERQWEAWRSVLGDEKSQfecrVRELQRMLDTEKQSRARADQRITESRQVvelavkehKAEIL 693
Cdd:pfam07888  173 rkqlqAKLQQTEEELRSLSKEFQELRNSLAQRDTQ----VLQLQDTITTLTQKLTTAHRKEAENEAL--------LEELR 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  694 ALQQALKEQKLKAESLSDKLNDL--EKKHAMLEMNARSLQ------QKLETE---RELKQRLLEEQAKLQQQMDLQKNHI 762
Cdd:pfam07888  241 SLQERLNASERKVEGLGEELSSMaaQRDRTQAELHQARLQaaqltlQLADASlalREGRARWAQERETLQQSAEADKDRI 320

                          330       340
                   ....*....|....*....|....*...
gi 1039770402  763 FRLTQGLQEALDRADLLKTERSDLEYQL 790
Cdd:pfam07888  321 EKLSAELQRLEERLQEERMEREKLEVEL 348
46 PHA02562
endonuclease subunit; Provisional
 661-820 8.38e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 43.85  E-value: 8.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  661 DTEKQSRARADQRITESRQVVELAVKE---HKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQ------ 731
Cdd:PHA02562   202 KNIEEQRKKNGENIARKQNKYDELVEEaktIKAEIEELTDELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQkvikmy 281

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  732 ----------QKLETERELKQRLLEEQAKLQQQMDLQKNHIfrltQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEk 801
Cdd:PHA02562   282 ekggvcptctQQISEGPDRITKIKDKLKELQHSLEKLDTAI----DELEEIMDEFNEQSKKLLELKNKISTNKQSLITL- 356

                          170
                   ....*....|....*....
gi 1039770402  802 vkmEGTISQQTKLIDFLQA 820
Cdd:PHA02562   357 ---VDKAKKVKAAIEELQA 372
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
163-257 8.97e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 44.08  E-value: 8.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  163 GEYSKLEKINAEQQLKIQELQEKLEKAVKAsteatellqniRQAKERAERELEKLHNREDSsegIKKKLVEAEERRHSLE 242
Cdd:COG2433    427 AEVEELEAELEEKDERIERLERELSEARSE-----------ERREIRKDREISRLDREIER---LERELEEERERIEELK 492

                           90
                   ....*....|....*
gi 1039770402  243 NKVKRLETMERRENR 257
Cdd:COG2433    493 RKLERLKELWKLEHS 507
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 68-631 9.05e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 44.27  E-value: 9.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   68 EVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLM-----MNQL------EEDLVSARRRSDLYESELRESRLA 136
Cdd:TIGR01612 1230 KIDEEKKKSEHMIKAMEAYIEDLDEIKEKSPEIENEMGIEMdikaeMETFnishddDKDHHIISKKHDENISDIREKSLK 1309

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  137 -AEEFKRKAN------ECQHKLMKAKDQGKpEVGEYskLEKI-NAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKE 208
Cdd:TIGR01612 1310 iIEDFSEESDindikkELQKNLLDAQKHNS-DINLY--LNEIaNIYNILKLNKIKKIIDEVKEYTKEIEENNKNIKDELD 1386

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  209 RAERELEKLhnREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQV 288
Cdd:TIGR01612 1387 KSEKLIKKI--KDDINLEECKSKIESTLDDKDIDECIKKIKELKNHILSEESNIDTYFKNADENNENVLLLFKNIEMADN 1464

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  289 SAQHLevhLKQKEQHYEEKIKVLDNQIKKDLaDKEslenmmQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELS 368
Cdd:TIGR01612 1465 KSQHI---LKIKKDNATNDHDFNINELKEHI-DKS------KGCKDEADKNAKAIEKNKELFEQYKKDVTELLNKYSALA 1534

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  369 EANKLAansslftqRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEqlEKISHQD---HSDKSrlleletrlrevs 445
Cdd:TIGR01612 1535 IKNKFA--------KTKKDSEIIIKEIKDAHKKFILEAEKSEQKIKEIKK--EKFRIEDdaaKNDKS------------- 1591

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  446 leheeqklelKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEEttaeaeeeIQALTAHRDEiqrkfdalrns 525
Cdd:TIGR01612 1592 ----------NKAAIDIQLSLENFENKFLKISDIKKKINDCLKETESIEKK--------ISSFSIDSQD----------- 1642

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  526 cTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREIterEMQLTsQKQAQLSAPDLQTME 605
Cdd:TIGR01612 1643 -TELKENGDNLNSLQEFLESLKDQKKNIEDKKKELDELDSEIEKIEIDVDQHKKNY---EIGII-EKIKEIAIANKEEIE 1717

                          570       580       590
                   ....*....|....*....|....*....|...
gi 1039770402  606 ALKTTCTMLEEQVL------DLEALN-DELLEK 631
Cdd:TIGR01612 1718 SIKELIEPTIENLIssfntnDLEGIDpNEKLEE 1750
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 59-485 9.17e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 43.73  E-value: 9.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   59 KRSLEQARMEVSQEDD----KALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEdlvsarrrsdlyesELRESR 134
Cdd:pfam07888   28 RAELLQNRLEECLQERaellQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKE--------------ELRQSR 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  135 LAAEEFKRKANEcqhklmkAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEK-AVKASTEATELlqniRQAKERAERE 213
Cdd:pfam07888   94 EKHEELEEKYKE-------LSASSEELSEEKDALLAQRAAHEARIRELEEDIKTlTQRVLERETEL----ERMKERAKKA 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  214 LEKLHNREDSSEGIKKKLVEAEERRHSLENKVKrletmerrenRLKDDIQTKSEQIQQMADKILELEEKHREAQvsaqhl 293
Cdd:pfam07888  163 GAQRKEEEAERKQLQAKLQQTEEELRSLSKEFQ----------ELRNSLAQRDTQVLQLQDTITTLTQKLTTAH------ 226

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  294 evhlkQKEQHYEekikvldnQIKKDLADKESLENMMQRHEEeahekgKILSEQKAMINAMDSKIRSLEQRIVELSEANKL 373
Cdd:pfam07888  227 -----RKEAENE--------ALLEELRSLQERLNASERKVE------GLGEELSSMAAQRDRTQAELHQARLQAAQLTLQ 287

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  374 AANSSLF--------------TQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQL--EKISH--QDHSDKSRLL 435
Cdd:pfam07888  288 LADASLAlregrarwaqeretLQQSAEADKDRIEKLSAELQRLEERLQEERMEREKLEVELgrEKDCNrvQLSESRRELQ 367

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|
gi 1039770402  436 ELETRLReVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALES 485
Cdd:pfam07888  368 ELKASLR-VAQKEKEQLQAEKQELLEYIRQLEQRLETVADAKWSEAALTS 416
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 181-585 1.01e-03

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 44.05  E-value: 1.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  181 ELQEKLEKAVKASTEATELlQNIRQAKERAERELEKLHNREDSSEGIKKK--LVEAEERRHSLE---------NKV---- 245
Cdd:PTZ00440  2171 EIIENIKKEIIEINENTEM-NTLENTADKLKELYENLKKKKNIINNIYKKinFIKLQEIENSSEkyndisklfNNVvetq 2249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  246 -KRLETMERRENRLKDDIQTKsEQIQQMADKILELEEKhREAQVSAQHLEVHLKQKEQHYEEKIKVLDN------QIKKD 318
Cdd:PTZ00440  2250 kKKLLDNKNKINNIKDKINDK-EKELINVDSSFTLESI-KTFNEIYDDIKSNIGDLYKLEDTNNDELKKvklyieNITHL 2327

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  319 LADKESLENMMQRHEEEahekGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLaansslfTQRNMKAQEEMISELRQQ 398
Cdd:PTZ00440  2328 LNRINTLINDLDNYQDE----NYGKDKNIELNNENNSYIIKTKEKINNLKEEFSK-------LLKNIKRNNTLCNNNNIK 2396

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  399 KFYLETqAGKLEAQNRKLEEQLEkishqdhsdksrlleletrLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQA 478
Cdd:PTZ00440  2397 DFISNI-GKSVETIKQRFSSNLP-------------------EKEKLHQIEENLNEIKNIMNETKRISNVDAFTNKILQD 2456

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  479 ARAALEsqlrqaKTELEETTAEAEEEIQALTAHRDEIQRKF----DALRNSCTVITDLEEQLNQLTEDNAELNNQ-NFYL 553
Cdd:PTZ00440  2457 IDNEKN------KENNNMNAEKIDDLIENVTSHNEKIKSELliinDALRRVKEKKDEMNKLFNSLTENNNNNNNSaKNIV 2530

                          410       420       430
                   ....*....|....*....|....*....|..
gi 1039770402  554 SKQLDEASGANDEIVQLRSEVDHLRREITERE 585
Cdd:PTZ00440  2531 DNSTYIINELESHVSKLNELLSYIDNEIKELE 2562
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
83-400 1.06e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 43.35  E-value: 1.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   83 IREQSRKLQEIKEQ--EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKAKDQGKP 160
Cdd:COG4372     33 LRKALFELDKLQEEleQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEE 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  161 EVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHS 240
Cdd:COG4372    113 LQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDELLKEA 192

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  241 LENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLA 320
Cdd:COG4372    193 NRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKD 272

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  321 DKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKF 400
Cdd:COG4372    273 TEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELADLLQLLLVGLLD 352
PLN03229 PLN03229
acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional
 54-334 1.09e-03

acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional


Pssm-ID: 178768 [Multi-domain]  Cd Length: 762  Bit Score: 43.69  E-value: 1.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   54 ECSSLKRSLEQARMEVSQEDDKALQllhdirEQSRKLQEIKEQEYQAQVEEMRLM--MNQLEEDLVSARRRSDLYESELR 131
Cdd:PLN03229   437 EVEKLKEQILKAKESSSKPSELALN------EMIEKLKKEIDLEYTEAVIAMGLQerLENLREEFSKANSQDQLMHPVLM 510

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  132 ESrlaaeefkrkanecQHKLMKAKDQGKPEVGEY----SKLEKINA--------EQQLKIQELQEKLEKAVKASTEATEL 199
Cdd:PLN03229   511 EK--------------IEKLKDEFNKRLSRAPNYlslkYKLDMLNEfsrakalsEKKSKAEKLKAEINKKFKEVMDRPEI 576

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  200 LQNIRQAKerAERELEKLHNREDSSEGIKKKLVEAEE----------RRHSLENKVKRLETMERRENRLKDDIQTKSEQI 269
Cdd:PLN03229   577 KEKMEALK--AEVASSGASSGDELDDDLKEKVEKMKKeielelagvlKSMGLEVIGVTKKNKDTAEQTPPPNLQEKIESL 654

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039770402  270 QQMADKILELEEKHREAQVSAQHLEVHL----KQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEE 334
Cdd:PLN03229   655 NEEINKKIERVIRSSDLKSKIELLKLEVakasKTPDVTEKEKIEALEQQIKQKIAEALNSSELKEKFEE 723
46 PHA02562
endonuclease subunit; Provisional
 367-587 1.22e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 43.46  E-value: 1.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  367 LSEANKLaaNSSLftqrnMKAQEEMISELRQQKFYLETQagkLEAQNRKLEEQlEKISHQDHSDKSrllELETRLREVSL 446
Cdd:PHA02562   165 LSEMDKL--NKDK-----IRELNQQIQTLDMKIDHIQQQ---IKTYNKNIEEQ-RKKNGENIARKQ---NKYDELVEEAK 230

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  447 EHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAK--------------------------TELEETTAE 500
Cdd:PHA02562   231 TIKAEIEELTDELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQkvikmyekggvcptctqqisegpdriTKIKDKLKE 310

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  501 AEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGA----NDEIVQLRSEVDH 576
Cdd:PHA02562   311 LQHSLEKLDTAIDELEEIMDEFNEQSKKLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEfvdnAEELAKLQDELDK 390

                          250
                   ....*....|.
gi 1039770402  577 LRREITEREMQ 587
Cdd:PHA02562   391 IVKTKSELVKE 401
mukB PRK04863
chromosome partition protein MukB;
5-750 1.22e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 43.79  E-value: 1.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402    5 EEAMMEQEMTR--LHRRVSEVEAVLSQKEVELKASETQrslleqdLATYITECSSLKRSLEQARMEVsQEDDKALQLLHD 82
Cdd:PRK04863   361 EERLEEQNEVVeeADEQQEENEARAEAAEEEVDELKSQ-------LADYQQALDVQQTRAIQYQQAV-QALERAKQLCGL 432

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   83 IREQSRKLQEIKEqEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKAnecqhklmkAKDQGKPEV 162
Cdd:PRK04863   433 PDLTADNAEDWLE-EFQAKEQEATEELLSLEQKLSVAQAAHSQFEQAYQLVRKIAGEVSRSE---------AWDVARELL 502

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  163 GEYSKlEKINAEQQlkiQELQEKLekavkasTEATELLQNIRQAkERAERELEKLHNR-EDSSEGIKKKLVEAEERRHSL 241
Cdd:PRK04863   503 RRLRE-QRHLAEQL---QQLRMRL-------SELEQRLRQQQRA-ERLLAEFCKRLGKnLDDEDELEQLQEELEARLESL 570

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  242 ----ENKVKRLETMERRENRLKDDIQ--TKSEQIQQMADKILE-LEEKHREAQVSAQHL----------EVHLKQKEQHY 304
Cdd:PRK04863   571 sesvSEARERRMALRQQLEQLQARIQrlAARAPAWLAAQDALArLREQSGEEFEDSQDVteymqqllerERELTVERDEL 650

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  305 EEKIKVLDNQIKK-DLADKESLENMMQRHEeeaHEKGKILSE---------------------QKAMINAMDSKIRSLEQ 362
Cdd:PRK04863   651 AARKQALDEEIERlSQPGGSEDPRLNALAE---RFGGVLLSEiyddvsledapyfsalygparHAIVVPDLSDAAEQLAG 727

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  363 R-----IVELSEANKLAANSSLFT-------------QRNM-------------KAQEEMISELRQQKFYLETQAGKLEA 411
Cdd:PRK04863   728 LedcpeDLYLIEGDPDSFDDSVFSveelekavvvkiaDRQWrysrfpevplfgrAAREKRIEQLRAEREELAERYATLSF 807

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  412 QNRKLEeqlekishqdhsdksRLLELETRLREVSL-----EHEEQKLELKRQltelqlSLQERESQLTALQAARAALESQ 486
Cdd:PRK04863   808 DVQKLQ---------------RLHQAFSRFIGSHLavafeADPEAELRQLNR------RRVELERALADHESQEQQQRSQ 866

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  487 LRQAKteleettaeaeEEIQALTAHRDEIQRKFDALRNSctVITDLEEQLNQLTEDNAELNNQNFYLSkQLDEasgandE 566
Cdd:PRK04863   867 LEQAK-----------EGLSALNRLLPRLNLLADETLAD--RVEEIREQLDEAEEAKRFVQQHGNALA-QLEP------I 926

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  567 IVQLRS---EVDHLRREITE-REMQLTSQKQAQLSAPDLQTMEALKttctmLEEQVLDLE---ALNDELLEKERQWEAWR 639
Cdd:PRK04863   927 VSVLQSdpeQFEQLKQDYQQaQQTQRDAKQQAFALTEVVQRRAHFS-----YEDAAEMLAknsDLNEKLRQRLEQAEQER 1001

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  640 SVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQ-VVELAVK-EHKAEILA------LQQALKEQKLKAESlsd 711
Cdd:PRK04863  1002 TRAREQLRQAQAQLAQYNQVLASLKSSYDAKRQMLQELKQeLQDLGVPaDSGAEERArarrdeLHARLSANRSRRNQ--- 1078

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|.
gi 1039770402  712 klndLEKKHAMLEMNARSLQQKL-ETERELKQ-RLLEEQAK 750
Cdd:PRK04863  1079 ----LEKQLTFCEAEMDNLTKKLrKLERDYHEmREQVVNAK 1115
PRK12704 PRK12704
phosphodiesterase; Provisional
 258-426 1.27e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 43.23  E-value: 1.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  258 LKDDIQTKSEQIQQMADKIleLEEKHREAqvsaqhlEVHLKQKEQHYEEKIKVLDNQIKKDLADKeslENMMQRHEEEAH 337
Cdd:PRK12704    25 RKKIAEAKIKEAEEEAKRI--LEEAKKEA-------EAIKKEALLEAKEEIHKLRNEFEKELRER---RNELQKLEKRLL 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  338 EKGKILSEQKAMINAMDSKIRSLEQRIVELseanklaansslftQRNMKAQEEMISELR-QQKFYLETQAG--KLEAQNR 414
Cdd:PRK12704    93 QKEENLDRKLELLEKREEELEKKEKELEQK--------------QQELEKKEEELEELIeEQLQELERISGltAEEAKEI 158

                          170
                   ....*....|..
gi 1039770402  415 KLEEQLEKISHQ 426
Cdd:PRK12704   159 LLEKVEEEARHE 170
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 169-369 1.29e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 43.38  E-value: 1.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  169 EKINAEQQLKIQELQEKLEKAV---KASTEATELLQNIRQAKEraERELEKLHNREDSS-EGIKKKLVEAEERRHSLENK 244
Cdd:PRK05771    38 EELSNERLRKLRSLLTKLSEALdklRSYLPKLNPLREEKKKVS--VKSLEELIKDVEEElEKIEKEIKELEEEISELENE 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  245 VKRLETMERRENRLKD-DIqtkseqiqqmaDKILELEEKH---REAQVSAQHLEVHLKQKEQHYEEKIKVLDN------- 313
Cdd:PRK05771   116 IKELEQEIERLEPWGNfDL-----------DLSLLLGFKYvsvFVGTVPEDKLEELKLESDVENVEYISTDKGyvyvvvv 184

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039770402  314 QIKKDLADKESLenmMQRHE---EEAHEKGK---ILSEQKAMINAMDSKIRSLEQRIVELSE 369
Cdd:PRK05771   185 VLKELSDEVEEE---LKKLGferLELEEEGTpseLIREIKEELEEIEKERESLLEELKELAK 243
C1_MRCK cd20809
protein kinase C conserved region 1 (C1 domain) found in the Myotonic dystrophy kinase-related ...
 955-1006 1.39e-03

protein kinase C conserved region 1 (C1 domain) found in the Myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) family; MRCK is thought to be a coincidence detector of signaling by the small GTPase Cdc42 and phosphoinositides. MRCK/Cdc42 signaling mediates myosin-dependent cell motility. MRCK has been shown to promote cytoskeletal reorganization, which affects many biological processes. Three isoforms of MRCK are known, named alpha, beta and gamma. MRCKgamma is expressed in heart and skeletal muscles, unlike MRCKalpha and MRCKbeta, which are expressed ubiquitously. MRCK consists of a serine/threonine kinase domain, a cysteine rich (C1) region, a PH domain and a p21 binding motif. This model corresponds to C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410359  Cd Length: 53  Bit Score: 38.41  E-value: 1.39e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039770402  955 HRFNVGLNMRATKCAVClDTVHFG--RQASKCLECQVMCHPKCSTCLPATCGLP 1006
Cdd:cd20809      1 HKFIVRTFSTPTKCNHC-TSLMVGlvRQGLVCEVCGYACHVSCADKAPQVCPVP 53
C1_MRCKalpha cd20864
protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related ...
 955-1008 1.39e-03

protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins; MRCK alpha, also called Cdc42-binding protein kinase alpha, DMPK-like alpha, or myotonic dystrophy protein kinase-like alpha, is a serine/threonine-protein kinase expressed ubiquitously in many tissues. It plays a role in the regulation of peripheral actin reorganization and neurite outgrowth. It may also play a role in the transferrin iron uptake pathway. MRCK alpha is an important downstream effector of Cdc42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410414  Cd Length: 60  Bit Score: 38.46  E-value: 1.39e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1039770402  955 HRFNVGLNMRATKCAVCLD-TVHFGRQASKCLECQVMCHPKCSTCLPATCGLPAE 1008
Cdd:cd20864      3 HQFVVKSFTTPTKCNQCTSlMVGLIRQGCTCEVCGFSCHVTCADKAPSVCPIPPE 57
Stathmin pfam00836
Stathmin family; The Stathmin family of proteins play an important role in the regulation of ...
 219-306 1.56e-03

Stathmin family; The Stathmin family of proteins play an important role in the regulation of the microtubule cytoskeleton. They regulate microtubule dynamics by promoting depolymerization of microtubules and/or preventing polymerization of tubulin heterodimers.


Pssm-ID: 459956 [Multi-domain]  Cd Length: 136  Bit Score: 40.41  E-value: 1.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  219 NREDSSEGIKKKLVEAEERRHSLE-NKVKRLETMERRENRLKDDIQTKSEQIQQMADKIL----ELEEKHREAQVSAqhL 293
Cdd:pfam00836   39 KKDSSLEEIQKKLEAAEERRKSLEaQKLKQLAEKREKEEEALQKADEENNNFSKMAEEKLkqkmEAYKENREAQIAA--L 116

                           90
                   ....*....|...
gi 1039770402  294 EVHLKQKEQHYEE 306
Cdd:pfam00836  117 KEKLKEKEKHVEE 129
C1_TNS1_v cd20888
protein kinase C conserved region 1 (C1 domain) found in tensin-1 (TNS1) variant and similar ...
 955-1002 1.56e-03

protein kinase C conserved region 1 (C1 domain) found in tensin-1 (TNS1) variant and similar proteins; Tensin-1 (TNS1) plays a role in fibrillar adhesion formation. It may be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton. This model corresponds to the C1 domain found in TNS1 variant. Typical TNS1 does not contain C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410438  Cd Length: 57  Bit Score: 38.31  E-value: 1.56e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1039770402  955 HRFNVGLNMRATKCAVCLDTVhfGRQASKCLECQVMCHPKC-----STCLPAT 1002
Cdd:cd20888      6 HTFKVKTFKKVKSCGICKQAI--TREGSTCRVCKLSCHKKCeakvaTPCVPAV 56
CCDC73 pfam15818
Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil ...
 85-313 1.57e-03

Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil containing proteins. The function is not known. The alternative name is sarcoma antigen NY-SAR-79.


Pssm-ID: 464893 [Multi-domain]  Cd Length: 1048  Bit Score: 43.40  E-value: 1.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   85 EQSRKLQEIKEQEYQAQVEEMR----LMMNQ----------LEEDLVSA----RRRSDLYESELRESRLAAEEFKRKANE 146
Cdd:pfam15818  119 EQKLQLHLLAKEDHHKQLNEIEkyyaTITGQfglvkenhgkLEQNVQEAiqlnKRLSALNKKQESEICSLKKELKKVTSD 198

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  147 cqhkLMKAKDQGKPEVGEysklEKIN-AEQQLKIQELQEKL----EKAVKASTEAT-----------------ELLQNIR 204
Cdd:pfam15818  199 ----LIKSKVTCQYKMGE----ENINlTIKEQKFQELQERLnmelELNKKINEEIThiqeekqdiiisfqhmqQLLQQQT 270

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  205 QAKERAEREL----EKLHNREDSSEGIKKKLVEAEERRHSLENKvkrletMERRENRLKDDIQTKSEQIQQMADKILELE 280
Cdd:pfam15818  271 QANTEMEAELkalkENNQTLERDNELQREKVKENEEKFLNLQNE------HEKALGTWKKHVEELNGEINEIKNELSSLK 344

                          250       260       270
                   ....*....|....*....|....*....|...
gi 1039770402  281 EKHREAQvsaqhlEVHLKQKEQHYEEKIKVLDN 313
Cdd:pfam15818  345 ETHIKLQ------EHYNKLCNQKKFEEDKKFQN 371
C1_ScPKC1-like_rpt1 cd20822
first protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae ...
 950-1003 1.66e-03

first protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae protein kinase C-like 1 (ScPKC1) and similar proteins; ScPKC1 is required for cell growth and for the G2 to M transition of the cell division cycle. It mediates a protein kinase cascade, activating BCK1 which itself activates MKK1/MKK2. The family also includes Schizosaccharomyces pombe PKC1 and PKC2, which are involved in the control of cell shape and act as targets of the inhibitor staurosporine. Members of this family contain two copies of the C1 domain. This model corresponds to the first one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410372  Cd Length: 52  Bit Score: 38.04  E-value: 1.66e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1039770402  950 HHNIPHRF-NVglnmraTKCAVCLDtvHFGRQASKCLECQVMCHPKCSTCLPATC 1003
Cdd:cd20822      3 HKFVQKQFyQI------MRCAVCGE--FLVNAGYQCEDCKYTCHKKCYEKVVTKC 49
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 36-257 1.92e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 42.44  E-value: 1.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   36 ASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQ--EYQAQVEEMRLMMNQLE 113
Cdd:COG4942     17 AQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQElaALEAELAELEKEIAELR 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  114 EDLvsaRRRSDLYESELRE----SRLAAEEFKRKANECQHKLMKAKDQGKPEVGEYSKLEKINAEQQL---KIQELQEKL 186
Cdd:COG4942     97 AEL---EAQKEELAELLRAlyrlGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAElaaLRAELEAER 173

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039770402  187 EKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEgikKKLVEAEERRHSLENKVKRLETMERRENR 257
Cdd:COG4942    174 AELEALLAELEEERAALEALKAERQKLLARLEKELAELA---AELAELQQEAEELEALIARLEAEAAAAAE 241
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 227-587 2.09e-03

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 42.53  E-value: 2.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  227 IKKKLVEAEE--RRHSLeNKVKRleTMERRENRLkDDIQTKSEQIQQMADKILELEEKHREAqvsAQHLEVH-------L 297
Cdd:pfam06160   65 IEELLFEAEElnDKYRF-KKAKK--ALDEIEELL-DDIEEDIKQILEELDELLESEEKNREE---VEELKDKyrelrktL 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  298 KQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHE-EEAHEkgkILSEQKAMINAMDSKIRSLEQRIVELseanklaan 376
Cdd:pfam06160  138 LANRFSYGPAIDELEKQLAEIEEEFSQFEELTESGDyLEARE---VLEKLEEETDALEELMEDIPPLYEEL--------- 205

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  377 sslftQRNMKAQ----EEMISELRQQKFYLETQagKLEAQNRKLEEQLEKISHQdhSDKSRLLELETRLREVS------- 445
Cdd:pfam06160  206 -----KTELPDQleelKEGYREMEEEGYALEHL--NVDKEIQQLEEQLEENLAL--LENLELDEAEEALEEIEeridqly 276

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  446 --LEHE-EQKLELKRQLTELQLSLQERESQLTALQA--ARAALESQLrqakteleetTAEAEEEIQALTAHRDEIQRKFD 520
Cdd:pfam06160  277 dlLEKEvDAKKYVEKNLPEIEDYLEHAEEQNKELKEelERVQQSYTL----------NENELERVRGLEKQLEELEKRYD 346

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039770402  521 ALR----NSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASgaNDEIVqLRSEVDHLRREITE--REMQ 587
Cdd:pfam06160  347 EIVerleEKEVAYSELQEELEEILEQLEEIEEEQEEFKESLQSLR--KDELE-AREKLDEFKLELREikRLVE 416
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 10-335 2.12e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 42.69  E-value: 2.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   10 EQEMTRLHRRVSEVEAVLSQKEvelKASETQRsllEQDLATYITEC-SSLKRSLEQARMEVSQEDdkaLQLLHDIREQSR 88
Cdd:NF033838   131 KKDTLEPGKKVAEATKKVEEAE---KKAKDQK---EEDRRNYPTNTyKTLELEIAESDVEVKKAE---LELVKEEAKEPR 201

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   89 KLQEIKEQEY-----QAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEE-------FKRKANECQHKLMKAKD 156
Cdd:NF033838   202 DEEKIKQAKAkveskKAEATRLEKIKTDREKAEEEAKRRADAKLKEAVEKNVATSEqdkpkrrAKRGVLGEPATPDKKEN 281

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  157 QGK---PEVGEYS------KLEKINAEQQLKIQELQEKLEK----------AVKASTEATELLQNIRQAKErAERELEKL 217
Cdd:NF033838   282 DAKssdSSVGEETlpspslKPEKKVAEAEKKVEEAKKKAKDqkeedrrnypTNTYKTLELEIAESDVKVKE-AELELVKE 360

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  218 HNREDSSEgikKKLVEAEERRHSLENKVKRLEtmerrenRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVhl 297
Cdd:NF033838   361 EAKEPRNE---EKIKQAKAKVESKKAEATRLE-------KIKTDRKKAEEEAKRKAAEEDKVKEKPAEQPQPAPAPQP-- 428

                          330       340       350
                   ....*....|....*....|....*....|....*...
gi 1039770402  298 kQKEQHYEEKIKVLDNQIKKDlaDKESLENMMQRHEEE 335
Cdd:NF033838   429 -EKPAPKPEKPAEQPKAEKPA--DQQAEEDYARRSEEE 463
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 67-628 2.32e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 43.02  E-value: 2.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   67 MEVSQEDDKALQLLHDIREQ----------SRKLQEIKEQEY-QAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRL 135
Cdd:COG3096    488 VERSQAWQTARELLRRYRSQqalaqrlqqlRAQLAELEQRLRqQQNAERLLEEFCQRIGQQLDAAEELEELLAELEAQLE 567

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  136 AAEEFKRKANECQHKLMKAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQN------------- 202
Cdd:COG3096    568 ELEEQAAEAVEQRSELRQQLEQLRARIKELAARAPAWLAAQDALERLREQSGEALADSQEVTAAMQQllerereatverd 647

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  203 -IRQAKERAERELEKLHNR------------------------EDSS-----------------------EGIKKKLV-- 232
Cdd:COG3096    648 eLAARKQALESQIERLSQPggaedprllalaerlggvllseiyDDVTledapyfsalygparhaivvpdlSAVKEQLAgl 727

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  233 ----------------------EAEErrhsLENKV-----------KRLETMER-----RENRLKDDIQTKSEQIQQMAD 274
Cdd:COG3096    728 edcpedlyliegdpdsfddsvfDAEE----LEDAVvvklsdrqwrySRFPEVPLfgraaREKRLEELRAERDELAEQYAK 803

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  275 KILELEEKHREAQ----VSAQHLEVHLkqkEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEkgkiLSEQKAMI 350
Cdd:COG3096    804 ASFDVQKLQRLHQafsqFVGGHLAVAF---APDPEAELAALRQRRSELERELAQHRAQEQQLRQQLDQ----LKEQLQLL 876

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  351 NAMDSKI-----RSLEQRIVELSEANKLAANSSLFTQRNMKAQ---EEMIS----------ELRQQKFYLETQAGKLEAQ 412
Cdd:COG3096    877 NKLLPQAnlladETLADRLEELREELDAAQEAQAFIQQHGKALaqlEPLVAvlqsdpeqfeQLQADYLQAKEQQRRLKQQ 956

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  413 NRKLEEQLEKISHQDHSDKSRLL----ELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLR 488
Cdd:COG3096    957 IFALSEVVQRRPHFSYEDAVGLLgensDLNEKLRARLEQAEEARREAREQLRQAQAQYSQYNQVLASLKSSRDAKQQTLQ 1036

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  489 QAKTELEETTAEAEEEIQALTA-HRDEIQRKFDALRNSCtviTDLEEQLnQLTEdnAELNNQNFYLSKQLDEASGANDEI 567
Cdd:COG3096   1037 ELEQELEELGVQADAEAEERARiRRDELHEELSQNRSRR---SQLEKQL-TRCE--AEMDSLQKRLRKAERDYKQEREQV 1110

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039770402  568 VQLRSEVDHLRREITER--EMQLTSQKQAQLSAPDLQTM--EALKTtctmLEEQVLDLEALNDEL 628
Cdd:COG3096   1111 VQAKAGWCAVLRLARDNdvERRLHRRELAYLSADELRSMsdKALGA----LRLAVADNEHLRDAL 1171
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 37-236 2.70e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 42.12  E-value: 2.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   37 SETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQ--EYQAQVEEMRlmmNQLEE 114
Cdd:COG3883     14 ADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEiaEAEAEIEERR---EELGE 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  115 DLVSARR--RSDLYESELRESRLAAEEFKR-----KANECQHKLMKAKDQGKPEVGEY-SKLEKINAEQQLKIQELQEKL 186
Cdd:COG3883     91 RARALYRsgGSVSYLDVLLGSESFSDFLDRlsalsKIADADADLLEELKADKAELEAKkAELEAKLAELEALKAELEAAK 170

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1039770402  187 EKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEE 236
Cdd:COG3883    171 AELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAA 220
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 9-218 2.70e-03

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 42.15  E-value: 2.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402    9 MEQEMTRLHRRVSEVEAVLSQKEVELKA-----SETQRSLLEQ-------DLATYITEcssLKRSLEQARMEVSQ-EDDK 75
Cdd:pfam06160  184 LEEETDALEELMEDIPPLYEELKTELPDqleelKEGYREMEEEgyalehlNVDKEIQQ---LEEQLEENLALLENlELDE 260

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   76 ALQLLHDIREQSRKLQEIKEQEYQA-------------QVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFK- 141
Cdd:pfam06160  261 AEEALEEIEERIDQLYDLLEKEVDAkkyveknlpeiedYLEHAEEQNKELKEELERVQQSYTLNENELERVRGLEKQLEe 340

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  142 -RKANECQHKLMKAKDQGKPEVGE-----YSKLEKINAEQQlkiqELQEKLEKAVKASTEATELLQNIRQAKERAERELE 215
Cdd:pfam06160  341 lEKRYDEIVERLEEKEVAYSELQEeleeiLEQLEEIEEEQE----EFKESLQSLRKDELEAREKLDEFKLELREIKRLVE 416


                   ...
gi 1039770402  216 KLH 218
Cdd:pfam06160  417 KSN 419
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 102-242 2.93e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 42.51  E-value: 2.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  102 VEEMRLMMNQLEEDLvsarrrSDLYESeLRESRLAAEEfkrKANECQHKLMKAKDQgKPEVGEysKLEKINAEQQLKIQE 181
Cdd:PRK00409   504 IEEAKKLIGEDKEKL------NELIAS-LEELERELEQ---KAEEAEALLKEAEKL-KEELEE--KKEKLQEEEDKLLEE 570

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770402  182 LQEKLEKAVKAST-EATELLQNIR-----QAKERAERELEKLHNR-EDSSEGIKKKLVEAEERRHSLE 242
Cdd:PRK00409   571 AEKEAQQAIKEAKkEADEIIKELRqlqkgGYASVKAHELIEARKRlNKANEKKEKKKKKQKEKQEELK 638
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
 461-829 2.94e-03

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 41.98  E-value: 2.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  461 ELQLSLQERESQLTALQAARAALESQLRQAKteleettaeaeeeiqaltahrdEIQRKFDALRNSCTVIT----DLEEQL 536
Cdd:pfam05622   11 ELAQRCHELDQQVSLLQEEKNSLQQENKKLQ----------------------ERLDQLESGDDSGTPGGkkylLLQKQL 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  537 NQLTEDN--------------AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRrEITER----EMQLTSQKQAqlsa 598
Cdd:pfam05622   69 EQLQEENfrletarddyrikcEELEKEVLELQHRNEELTSLAEEAQALKDEMDILR-ESSDKvkklEATVETYKKK---- 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  599 pdLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQfecrVRELQRMLDTE-----------KQSR 667
Cdd:pfam05622  144 --LEDLGDLRRQVKLLEERNAEYMQRTLQLEEELKKANALRGQLETYKRQ----VQELHGKLSEEskkadklefeyKKLE 217

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  668 A------RADQRITESRQVVELAVKE-----------HKAEILALQQALKEQKLKAESLS----DKLNDLEKKHAMLEMN 726
Cdd:pfam05622  218 EklealqKEKERLIIERDTLRETNEElrcaqlqqaelSQADALLSPSSDPGDNLAAEIMPaeirEKLIRLQHENKMLRLG 297

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  727 AR--------SLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLEniQVLYS 798
Cdd:pfam05622  298 QEgsyrerltELQQLLEDANRRKNELETQNRLANQRILELQQQVEELQKALQEQGSKAEDSSLLKQKLEEHLE--KLHEA 375

                          410       420       430
                   ....*....|....*....|....*....|.
gi 1039770402  799 HEKvkmegtISQQTKLIDFLQAKMDQPAKKK 829
Cdd:pfam05622  376 QSE------LQKKKEQIEELEPKQDSNLAQK 400
PRK12704 PRK12704
phosphodiesterase; Provisional
 670-806 2.94e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.07  E-value: 2.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  670 ADQRITESRQVVELAVKEHKAEILALQQALKEqklKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQA 749
Cdd:PRK12704    62 AKEEIHKLRNEFEKELRERRNELQKLEKRLLQ---KEENLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIE 138

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1039770402  750 KLQQQMDlqknHIFRLTQglQEAldRADLLKTERSDLEYQlenIQVLY--SHEKVKMEG 806
Cdd:PRK12704   139 EQLQELE----RISGLTA--EEA--KEILLEKVEEEARHE---AAVLIkeIEEEAKEEA 186
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
 505-624 3.02e-03

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 41.59  E-value: 3.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  505 IQALTahrDEIQRKFDALRNSCT-VITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAN--DEIVQLRSEVDHLRREI 581
Cdd:cd22656    119 IKALL---DDLLKEAKKYQDKAAkVVDKLTDFENQTEKDQTALETLEKALKDLLTDEGGAIarKEIKDLQKELEKLNEEY 195

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1039770402  582 TER---EMQLTSQKQAQLSApDLQTMEALKTTCTMLEEQVLDLEAL 624
Cdd:cd22656    196 AAKlkaKIDELKALIADDEA-KLAAALRLIADLTAADTDLDNLLAL 240
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
10-217 3.06e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.21  E-value: 3.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   10 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQ---------DLATYITECSS-----------------LKRSLE 63
Cdd:COG4913    616 EAELAELEEELAEAEERLEALEAELDALQERREALQRlaeyswdeiDVASAEREIAEleaelerldassddlaaLEEQLE 695

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   64 QARMEVSQEDDKALQLLHDIREQSRKLQEIKEQ--EYQAQVEEMRLMMNQLEEDLVSARRRS---DLYESELRE---SRL 135
Cdd:COG4913    696 ELEAELEELEEELDELKGEIGRLEKELEQAEEEldELQDRLEAAEDLARLELRALLEERFAAalgDAVERELREnleERI 775

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  136 AAEefKRKANECQHKLMKAKDQGKPE--------------VGEY-SKLEKINAEqqlKIQELQEKLEKAVKASTEA--TE 198
Cdd:COG4913    776 DAL--RARLNRAEEELERAMRAFNREwpaetadldadlesLPEYlALLDRLEED---GLPEYEERFKELLNENSIEfvAD 850

                          250
                   ....*....|....*....
gi 1039770402  199 LLQNIRQAKERAERELEKL 217
Cdd:COG4913    851 LLSKLRRAIREIKERIDPL 869
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 164-771 3.44e-03

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 42.05  E-value: 3.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  164 EYSKLEKINAEQQLKIQELQEKLEKAVKASTE--------ATELLQNIRQAKERAERELEKLHNREDSSegikkkLVEAE 235
Cdd:pfam07111   87 ETSLQQKMRLEAQAMELDALAVAEKAGQAEAEglraalagAEMVRKNLEEGSQRELEEIQRLHQEQLSS------LTQAH 160

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  236 ERrhSLENKVKRLETMERRENRLKddiQTKSEQIQQMAdkileleekhrEAQVSAQHLEVHLKQKEQHYEEKIKVLDNqI 315
Cdd:pfam07111  161 EE--ALSSLTSKAEGLEKSLNSLE---TKRAGEAKQLA-----------EAQKEAELLRKQLSKTQEELEAQVTLVES-L 223

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  316 KKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLaansslftqrnmkaQEEMISEL 395
Cdd:pfam07111  224 RKYVGEQVPPEVHSQTWELERQELLDTMQHLQEDRADLQATVELLQVRVQSLTHMLAL--------------QEEELTRK 289

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  396 RQQKFYLETQAGKleaqnrkleeqleKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQlslqereSQLTA 475
Cdd:pfam07111  290 IQPSDSLEPEFPK-------------KCRSLLNRWREKVFALMVQLKAQDLEHRDSVKQLRGQVAELQ-------EQVTS 349

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  476 LQAARAALESQLrQAKTELEETTAEAEEEIQAltahrdEIQRKFDALRNSCTVITDLEEQL----NQLTEDNAELNNQNF 551
Cdd:pfam07111  350 QSQEQAILQRAL-QDKAAEVEVERMSAKGLQM------ELSRAQEARRRQQQQTASAEEQLkfvvNAMSSTQIWLETTMT 422

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  552 YLSKQLDEASGANDEIVQLRSEVdHLRREITEREMQLTSQKQAQ----LSAPDLQTMEALKTTCTMLEEQVLDLE-ALND 626
Cdd:pfam07111  423 RVEQAVARIPSLSNRLSYAVRKV-HTIKGLMARKVALAQLRQEScpppPPAPPVDADLSLELEQLREERNRLDAElQLSA 501

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  627 ELLEKE-----RQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKE 701
Cdd:pfam07111  502 HLIQQEvgrarEQGEAERQQLSEVAQQLEQELQRAQESLASVGQQLEVARQGQQESTEEAASLRQELTQQQEIYGQALQE 581

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  702 QKLKAES-----LSD---KLNDLEKKHAMLEMNARSLQQKLETERELKQ---RLLEEQAKLQQQmdlqknhifRLTQGLQ 770
Cdd:pfam07111  582 KVAEVETrlreqLSDtkrRLNEARREQAKAVVSLRQIQHRATQEKERNQelrRLQDEARKEEGQ---------RLARRVQ 652


                   .
gi 1039770402  771 E 771
Cdd:pfam07111  653 E 653
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 131-873 3.48e-03

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 42.51  E-value: 3.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  131 RESRLAAEEFKRKANECQHKLMKAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERA 210
Cdd:PTZ00440   435 LYSNLEIIEIKKKYDEKINELKKSINQLKTLISIMKSFYDLIISEKDSMDSKEKKESSDSNYQEKVDELLQIINSIKEKN 514

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  211 ERELEKLHNREDSS---EGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQ 287
Cdd:PTZ00440   515 NIVNNNFKNIEDYYitiEGLKNEIEGLIELIKYYLQSIETLIKDEKLKRSMKNDIKNKIKYIEENVDHIKDIISLNDEID 594

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  288 VSAQHLEVHLKQKEQHYEEKIKVldnqiKKDLADKESlENMMQRHEEEAHE----KGKILSEQKAMINAMDSKirsleQR 363
Cdd:PTZ00440   595 NIIQQIEELINEALFNKEKFINE-----KNDLQEKVK-YILNKFYKGDLQElldeLSHFLDDHKYLYHEAKSK-----ED 663

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  364 IVEL-----SEANKLA-ANSSLFTQ--RNMKAQEEMISELRQQKfyletqagkleaqnrkLEEQLEKIsHQDHSDKSRLL 435
Cdd:PTZ00440   664 LQTLlntskNEYEKLEfMKSDNIDNiiKNLKKELQNLLSLKENI----------------IKKQLNNI-EQDISNSLNQY 726

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  436 -----ELETRLREvsLEHEEQKLELKRQ-----LTELQLSLQERESQLTALQAaraaLESQLRQAKTELEETTAEAEEEI 505
Cdd:PTZ00440   727 tikynDLKSSIEE--YKEEEEKLEVYKHqiinrKNEFILHLYENDKDLPDGKN----TYEEFLQYKDTILNKENKISNDI 800

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  506 QALtahRDEIQRKFDALRNSCTVITDLEeqlNQLTEDNAELNNQNFYLSKQLDEASGANDE--IVQLRSEVDHLRREITE 583
Cdd:PTZ00440   801 NIL---KENKKNNQDLLNSYNILIQKLE---AHTEKNDEELKQLLQKFPTEDENLNLKELEkeFNENNQIVDNIIKDIEN 874

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  584 REMQLTSQKQAQL----SAPDLQTMEALKTTCTMLEEQVLDLEAL--NDELLEKerqweawrsvlgDEKSQFECRVRELQ 657
Cdd:PTZ00440   875 MNKNINIIKTLNIainrSNSNKQLVEHLLNNKIDLKNKLEQHMKIinTDNIIQK------------NEKLNLLNNLNKEK 942

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  658 RMLDtekqsraradqritesRQVVELAVKEHKAEILALQQALKEQKLKAESLSD-KLNDLEKKhamlEMNARSLQQKLET 736
Cdd:PTZ00440   943 EKIE----------------KQLSDTKINNLKMQIEKTLEYYDKSKENINGNDGtHLEKLDKE----KDEWEHFKSEIDK 1002

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  737 ERELKQRLleeQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTER--SDLEYQLENIQVLYSHEKVKMEGTISQQTKL 814
Cdd:PTZ00440  1003 LNVNYNIL---NKKIDDLIKKQHDDIIELIDKLIKEKGKEIEEKVDQyiSLLEKMKTKLSSFHFNIDIKKYKNPKIKEEI 1079

                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1039770402  815 IDFlqakmdqpAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQK 873
Cdd:PTZ00440  1080 KLL--------EEKVEALLKKIDENKNKLIEIKNKSHEHVVNADKEKNKQTEHYNKKKK 1130
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 27-191 3.63e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.06  E-value: 3.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   27 LSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQeyQAQVEEMR 106
Cdd:COG1579     12 LQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQ--LGNVRNNK 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  107 lMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKAKDQGKPEVGEyskLEKINAEQQLKIQELQEKL 186
Cdd:COG1579     90 -EYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAE---LDEELAELEAELEELEAER 165


                   ....*
gi 1039770402  187 EKAVK 191
Cdd:COG1579    166 EELAA 170
PRK12704 PRK12704
phosphodiesterase; Provisional
 59-217 3.65e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 41.69  E-value: 3.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   59 KRSLEQARMEVSQEDDKAL----QLLHDIREQ-----SRKLQEIKEQEYQAQVEEMRLmmNQLEEDLVSARRRSDLYESE 129
Cdd:PRK12704    41 KRILEEAKKEAEAIKKEALleakEEIHKLRNEfekelRERRNELQKLEKRLLQKEENL--DRKLELLEKREEELEKKEKE 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  130 LRESRlaaEEFKRKANECQHKLMKAKDqgkpevgeysKLEKINA--EQQLKiQELQEKLEKavKASTEATELLQNI-RQA 206
Cdd:PRK12704   119 LEQKQ---QELEKKEEELEELIEEQLQ----------ELERISGltAEEAK-EILLEKVEE--EARHEAAVLIKEIeEEA 182

                          170
                   ....*....|.
gi 1039770402  207 KERAERELEKL 217
Cdd:PRK12704   183 KEEADKKAKEI 193
C1_PKD_rpt2 cd20796
second protein kinase C conserved region 1 (C1 domain) found in the family of protein kinase D ...
 954-1003 3.66e-03

second protein kinase C conserved region 1 (C1 domain) found in the family of protein kinase D (PKD); PKDs are important regulators of many intracellular signaling pathways such as ERK and JNK, and cellular processes including the organization of the trans-Golgi network, membrane trafficking, cell proliferation, migration, and apoptosis. They are activated in a PKC-dependent manner by many agents including diacylglycerol (DAG), PDGF, neuropeptides, oxidative stress, and tumor-promoting phorbol esters, among others. Mammals harbor three types of PKDs: PKD1 (or PKCmu), PKD2, and PKD3 (or PKCnu). PKDs contain N-terminal tandem cysteine-rich zinc binding C1 (PKC conserved region 1), central PH (Pleckstrin Homology), and C-terminal catalytic kinase domains. This model corresponds to the second C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410346  Cd Length: 54  Bit Score: 37.27  E-value: 3.66e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1039770402  954 PHRFNVGLNMRATKCAVCLDTVH-FGRQASKCLECQVMCHPKCSTCLPATC 1003
Cdd:cd20796      1 PHTFVVHTYTKPTVCQHCKKLLKgLFRQGLQCKDCKFNCHKKCAEKVPKDC 51
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 67-405 3.74e-03

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 41.76  E-value: 3.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   67 MEVSQEDDKALQLLHDIREQSRK----LQEIKEQEyqaqvEEMRLMMNQLEEDLVSARR----RSDLYES--ELRESRLA 136
Cdd:pfam06160   82 KKAKKALDEIEELLDDIEEDIKQileeLDELLESE-----EKNREEVEELKDKYRELRKtllaNRFSYGPaiDELEKQLA 156

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  137 AEEFKRKANEcqhKLMkakdqgkpEVGEYSKLEKINAEQQLKIQELQEKLEKA----VKASTE----ATELLQNIRQAKE 208
Cdd:pfam06160  157 EIEEEFSQFE---ELT--------ESGDYLEAREVLEKLEEETDALEELMEDIpplyEELKTElpdqLEELKEGYREMEE 225

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  209 --------RAERELEKLHNR-EDSSEGIKK-KLVEAEERRHSLENKVKRL-ETMErRENRLKDDIQTKSEQIQQMadkIL 277
Cdd:pfam06160  226 egyalehlNVDKEIQQLEEQlEENLALLENlELDEAEEALEEIEERIDQLyDLLE-KEVDAKKYVEKNLPEIEDY---LE 301

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  278 ELEEKHREAQVSAQHLEV--HLKQKEqhyEEKIKVLDNQIkkdladkESLENMMQRHEEEAHEKGKILSEQKAMINAMDS 355
Cdd:pfam06160  302 HAEEQNKELKEELERVQQsyTLNENE---LERVRGLEKQL-------EELEKRYDEIVERLEEKEVAYSELQEELEEILE 371

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1039770402  356 KIRSLEQRIVELSEanKLAansSLFTQrNMKAQE---EMISELRQQKFYLETQ 405
Cdd:pfam06160  372 QLEEIEEEQEEFKE--SLQ---SLRKD-ELEAREkldEFKLELREIKRLVEKS 418
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 505-708 4.02e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 41.35  E-value: 4.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  505 IQALTAHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNnqnfylsKQLDEAsgaNDEIVQLRSEVDHLRREITER 584
Cdd:COG3883     25 LSELQAELEAAQAELDALQAE---LEELNEEYNELQAELEALQ-------AEIDKL---QAEIAEAEAEIEERREELGER 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  585 --------------EMQLTSQKQA----------QLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRS 640
Cdd:COG3883     92 aralyrsggsvsylDVLLGSESFSdfldrlsalsKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKA 171

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770402  641 VLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAES 708
Cdd:COG3883    172 ELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 239
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 11-244 4.07e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 41.34  E-value: 4.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   11 QEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQE-DDKALQLLHDIREQSRK 89
Cdd:pfam15905   87 QERGEQDKRLQALEEELEKVEAKLNAAVREKTSLSASVASLEKQLLELTRVNELLKAKFSEDgTQKKMSSLSMELMKLRN 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   90 LQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFK---RKANECQHKLMKAKDQGKPEVGEYS 166
Cdd:pfam15905  167 KLEAKMKEVMAKQEGMEGKLQVTQKNLEHSKGKVAQLEEKLVSTEKEKIEEKsetEKLLEYITELSCVSEQVEKYKLDIA 246

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  167 KLEKINAEQQLKIQELQEKL-EKAVKAST---EATELLQNIRQAKERAEREL-EKLHNREDSSEGIKKKLVEAEERRHSL 241
Cdd:pfam15905  247 QLEELLKEKNDEIESLKQSLeEKEQELSKqikDLNEKCKLLESEKEELLREYeEKEQTLNAELEELKEKLTLEEQEHQKL 326


                   ...
gi 1039770402  242 ENK 244
Cdd:pfam15905  327 QQK 329
C1_TNS2 cd20887
protein kinase C conserved region 1 (C1 domain) found in tensin-2 and similar proteins; ...
 954-1006 4.30e-03

protein kinase C conserved region 1 (C1 domain) found in tensin-2 and similar proteins; Tensin-2 (TNS2), also called C1 domain-containing phosphatase and tensin (C1-TEN), or tensin-like C1 domain-containing phosphatase (TENC1), is an essential component for the maintenance of glomerular basement membrane (GBM) structures. It regulates cell motility and proliferation. It may have phosphatase activity. TNS2 reduces AKT1 phosphorylation, lowers AKT1 kinase activity, and interferes with AKT1 signaling. It contains an N-terminal region with a zinc finger (C1 domain), a protein tyrosine phosphatase (PTP)-like domain and a protein kinase 2 (C2) domain, and a C-terminal region with SH2 and pTyr binding (PTB) domains. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410437  Cd Length: 53  Bit Score: 37.07  E-value: 4.30e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1039770402  954 PHRFNVGLNMRATKCAVCLDTVhfGRQASKCLECQVMCHPKCSTCLPATCGLP 1006
Cdd:cd20887      2 PHSFKEKTFKKKRACAVCREPV--GGQGLVCRVCKVASHKKCEAKVTSACQPP 52
PRK12704 PRK12704
phosphodiesterase; Provisional
 686-813 5.78e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 41.30  E-value: 5.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  686 KEHKAEILAlQQALKEQKLKAESLsdklndleKKHAMLEMNARSLQQKLETERELKQRLLEEQA---KLQQQMDLQKNHI 762
Cdd:PRK12704    32 KIKEAEEEA-KRILEEAKKEAEAI--------KKEALLEAKEEIHKLRNEFEKELRERRNELQKlekRLLQKEENLDRKL 102

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1039770402  763 FRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEgTISQQTK 813
Cdd:PRK12704   103 ELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELE-RISGLTA 152
C1_Munc13 cd20807
protein kinase C conserved region 1 (C1 domain) found in the Munc13 family; The Munc13 gene ...
 955-1003 6.17e-03

protein kinase C conserved region 1 (C1 domain) found in the Munc13 family; The Munc13 gene family encodes a family of neuron-specific, synaptic molecules that bind to syntaxin, an essential mediator of neurotransmitter release. Munc13-1 is a component of presynaptic active zones in which it acts as an essential synaptic vesicle priming protein. Munc13-2 is essential for normal release probability at hippocampal mossy fiber synapses. Munc13-3 is almost exclusively expressed in the cerebellum. It acts as a tumor suppressor and plays a critical role in the formation of release sites with calcium channel nanodomains. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410357  Cd Length: 53  Bit Score: 36.30  E-value: 6.17e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1039770402  955 HRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 1003
Cdd:cd20807      1 HNFEVWTATTPTYCYECEGLLwGIARQGVRCTECGVKCHEKCKDLLNADC 50
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 173-398 6.40e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 40.97  E-value: 6.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  173 AEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSsegIKKKLVEAEERRHSLENKV-KRLETM 251
Cdd:COG3883     19 QAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDK---LQAEIAEAEAEIEERREELgERARAL 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  252 ERRENRLKD-DIQTKSEQIQQMADKILELEekhreaQVSAQHLEVHLKQKEQhyEEKIKVLDNQIKKDLADKESLENMMQ 330
Cdd:COG3883     96 YRSGGSVSYlDVLLGSESFSDFLDRLSALS------KIADADADLLEELKAD--KAELEAKKAELEAKLAELEALKAELE 167

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770402  331 RHEEEAHEKgkiLSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQ 398
Cdd:COG3883    168 AAKAELEAQ---QAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAA 232
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 198-298 6.43e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 41.22  E-value: 6.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  198 ELLQNIRQAKERAERELEKLhnREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKIL 277
Cdd:COG0542    411 EELDELERRLEQLEIEKEAL--KKEQDEASFERLAELRDELAELEEELEALKARWEAEKELIEEIQELKEELEQRYGKIP 488

                           90       100
                   ....*....|....*....|.
gi 1039770402  278 ELEEKHREAQVSAQHLEVHLK 298
Cdd:COG0542    489 ELEKELAELEEELAELAPLLR 509
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 305-487 7.01e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 39.91  E-value: 7.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  305 EEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRivelseanklaanssLFTQRN 384
Cdd:COG1579     23 EHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQ---------------LGNVRN 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  385 MKAQEEMISELRqqkfYLETQAGKLEAQNRKLEEQLEkishqdhsdksrllELETRLREVSLEHEEQKLELKRQLTELQL 464
Cdd:COG1579     88 NKEYEALQKEIE----SLKRRISDLEDEILELMERIE--------------ELEEELAELEAELAELEAELEEKKAELDE 149

                          170       180
                   ....*....|....*....|...
gi 1039770402  465 SLQERESQLTALQAARAALESQL 487
Cdd:COG1579    150 ELAELEAELEELEAEREELAAKI 172
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 457-888 7.38e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 41.19  E-value: 7.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  457 RQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITD----- 531
Cdd:PRK10929     2 RLIITFLMAWLLSWGAYAATAPDEKQITQELEQAKAAKTPAQAEIVEALQSALNWLEERKGSLERAKQYQQVIDNfpkls 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  532 --LEEQLNQLTED---------NAELNNQNFYLSKQLDEASGandeivQLRSEVDHLrREITEREMQLTSQKQA---QLS 597
Cdd:PRK10929    82 aeLRQQLNNERDEprsvppnmsTDALEQEILQVSSQLLEKSR------QAQQEQDRA-REISDSLSQLPQQQTEarrQLN 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  598 APDlQTMEALKTTCTMLEE-QVLDLEAlndellekerqweawrsvlgdEKSQFECRVRELQrmldtekQSRARADQRITE 676
Cdd:PRK10929   155 EIE-RRLQTLGTPNTPLAQaQLTALQA---------------------ESAALKALVDELE-------LAQLSANNRQEL 205

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  677 SRQVVELAVKEHkAEILALQQALKEQklkaeslsdkLNDLEKKHA--------MLEMNA----RSLQQKLETERELKQrL 744
Cdd:PRK10929   206 ARLRSELAKKRS-QQLDAYLQALRNQ----------LNSQRQREAeralesteLLAEQSgdlpKSIVAQFKINRELSQ-A 273

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  745 LEEQAklqQQMDL----QK---NHIFRLTQGLQ----------------EALdRADLLKTERSDLEYQLENIQVLYSHEK 801
Cdd:PRK10929   274 LNQQA---QRMDLiasqQRqaaSQTLQVRQALNtlreqsqwlgvsnalgEAL-RAQVARLPEMPKPQQLDTEMAQLRVQR 349

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  802 VKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFsrrkeDPALPTQVPL------QYNELKLALEKEKARCAELEEALQKTR 875
Cdd:PRK10929   350 LRYEDLLNKQPQLRQIRQADGQPLTAEQNRIL-----DAQLRTQRELlnsllsGGDTLILELTKLKVANSQLEDALKEVN 424

                          490
                   ....*....|...
gi 1039770402  876 ielrsareEAAHR 888
Cdd:PRK10929   425 --------EATHR 429
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 569-898 8.24e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.88  E-value: 8.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  569 QLRSEVDHLRREItEREMQLTSQKQAQLSAPDLQ-TMEALKTTCTMLEEQVLDLEALNDELLEKERqweawrsVLGDEKS 647
Cdd:pfam17380  300 RLRQEKEEKAREV-ERRRKLEEAEKARQAEMDRQaAIYAEQERMAMERERELERIRQEERKRELER-------IRQEEIA 371

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  648 QFECRVRELQRMLDTEKQSRARADQRITESRQvVELAVKEHkaeilalQQALKEQKLKAESLSDKlndlekkhamlEMNA 727
Cdd:pfam17380  372 MEISRMRELERLQMERQQKNERVRQELEAARK-VKILEEER-------QRKIQQQKVEMEQIRAE-----------QEEA 432

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  728 RSLQ-QKLETERELK-QRLLEEQAKLQQQMDlqknhifRLTQglQEALDRADLLKTERSDLEYQL---ENIQVLYSHEKV 802
Cdd:pfam17380  433 RQREvRRLEEERAREmERVRLEEQERQQQVE-------RLRQ--QEEERKRKKLELEKEKRDRKRaeeQRRKILEKELEE 503

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  803 KMEGTISQQTKLiDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPL----QYNELKLALEKEKARCaeleEALQKTRIEL 878
Cdd:pfam17380  504 RKQAMIEEERKR-KLLEKEMEERQKAIYEEERRREAEEERRKQQEMeerrRIQEQMRKATEERSRL----EAMEREREMM 578

                          330       340
                   ....*....|....*....|
gi 1039770402  879 RSAREEAAHRKATDHPHPST 898
Cdd:pfam17380  579 RQIVESEKARAEYEATTPIT 598
mukB PRK04863
chromosome partition protein MukB;
331-753 8.35e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 41.10  E-value: 8.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  331 RHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELS-EANKLAANSSLFTQRNMKAQEE---MISELRQQKfYLETQA 406
Cdd:PRK04863   276 RHANERRVHLEEALELRRELYTSRRQLAAEQYRLVEMArELAELNEAESDLEQDYQAASDHlnlVQTALRQQE-KIERYQ 354

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  407 GKLEAQNRKLEEQLEKISHQDhsdkSRLLELETRLREVslehEEQKLELKRQLTELQLSLQeresqltaLQAARAaleSQ 486
Cdd:PRK04863   355 ADLEELEERLEEQNEVVEEAD----EQQEENEARAEAA----EEEVDELKSQLADYQQALD--------VQQTRA---IQ 415

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  487 LRQAKteleettaeaeeeiQALtahrDEIQR--KFDALrnsctVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAN 564
Cdd:PRK04863   416 YQQAV--------------QAL----ERAKQlcGLPDL-----TADNAEDWLEEFQAKEQEATEELLSLEQKLSVAQAAH 472

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  565 DEIVQ----LRSEVDHLRRE-----ITEREMQLTSQKQAQLSAPDLQTmeALKTTCTMLEEQVlDLEALNDELLEKERQW 635
Cdd:PRK04863   473 SQFEQayqlVRKIAGEVSRSeawdvARELLRRLREQRHLAEQLQQLRM--RLSELEQRLRQQQ-RAERLLAEFCKRLGKN 549

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  636 EAWRSVLGDEKSQFECRVRELqrmldteKQSRARADQRITESRQVVElavkEHKAEIlalqQALKEQKLKAESLSDKLND 715
Cdd:PRK04863   550 LDDEDELEQLQEELEARLESL-------SESVSEARERRMALRQQLE----QLQARI----QRLAARAPAWLAAQDALAR 614

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039770402  716 L-EKKHAMLEMNAR---SLQQKLETEREL----------KQRLLEEQAKLQQ 753
Cdd:PRK04863   615 LrEQSGEEFEDSQDvteYMQQLLERERELtverdelaarKQALDEEIERLSQ 666
PRK12704 PRK12704
phosphodiesterase; Provisional
 227-414 9.17e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 40.53  E-value: 9.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  227 IKKKLVEAEERRhslenkVKRLETMERRENRLKDDIqtKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEE 306
Cdd:PRK12704    29 AEAKIKEAEEEA------KRILEEAKKEAEAIKKEA--LLEAKEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDR 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  307 kikvldnqiKKDLADKEslENMMQRHEEEAHEKGKILSEQKAMInamDSKIRSLEQRIVELSEANKLAANSSLFTQRNMK 386
Cdd:PRK12704   101 ---------KLELLEKR--EEELEKKEKELEQKQQELEKKEEEL---EELIEEQLQELERISGLTAEEAKEILLEKVEEE 166

                          170       180
                   ....*....|....*....|....*...
gi 1039770402  387 AQEEMISELRQqkfyLETQAgKLEAQNR 414
Cdd:PRK12704   167 ARHEAAVLIKE----IEEEA-KEEADKK 189
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
 69-321 9.54e-03

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 39.63  E-value: 9.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   69 VSQEDDKALQLLHDIREQSRKLQEiKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRkanecq 148
Cdd:pfam00261    6 IKEELDEAEERLKEAMKKLEEAEK-RAEKAEAEVAALNRRIQLLEEELERTEERLAEALEKLEEAEKAADESER------ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  149 hkLMKAkdqgkpevgeyskLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGik 228
Cdd:pfam00261   79 --GRKV-------------LENRALKDEEKMEILEAQLKEAKEIAEEADRKYEEVARKLVVVEGDLERAEERAELAES-- 141

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  229 kKLVEAEERRHSLENKVKRLETMERRENRLKDDiqtKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQ---HYE 305
Cdd:pfam00261  142 -KIVELEEELKVVGNNLKSLEASEEKASEREDK---YEEQIRFLTEKLKEAETRAEFAERSVQKLEKEVDRLEDeleAEK 217

                          250
                   ....*....|....*.
gi 1039770402  306 EKIKVLDNQIKKDLAD 321
Cdd:pfam00261  218 EKYKAISEELDQTLAE 233
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 11-290 9.99e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 40.71  E-value: 9.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   11 QEMTRLHRRVSE------VEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQ-----------ED 73
Cdd:COG3096    809 QKLQRLHQAFSQfvgghlAVAFAPDPEAELAALRQRRSELERELAQHRAQEQQLRQQLDQLKEQLQLlnkllpqanllAD 888

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402   74 DKALQLLHDIREQSRKLQEIKE--QEYQAQVEEMrlmmnqleEDLVSARRRSDLYESELRESRLAAEEFKRKAnecQHKL 151
Cdd:COG3096    889 ETLADRLEELREELDAAQEAQAfiQQHGKALAQL--------EPLVAVLQSDPEQFEQLQADYLQAKEQQRRL---KQQI 957

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  152 MKAKD--QGKPEVGeYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNI-----------------RQAKER--- 209
Cdd:COG3096    958 FALSEvvQRRPHFS-YEDAVGLLGENSDLNEKLRARLEQAEEARREAREQLRQAqaqysqynqvlaslkssRDAKQQtlq 1036

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770402  210 -AERELEKLHNREDSsegikkklvEAEERRHSLENKVK-RLETMERRENRLKDDIQTKSEQIQQMADKILELEEKH---R 284
Cdd:COG3096   1037 eLEQELEELGVQADA---------EAEERARIRRDELHeELSQNRSRRSQLEKQLTRCEAEMDSLQKRLRKAERDYkqeR 1107


                   ....*.
gi 1039770402  285 EAQVSA 290
Cdd:COG3096   1108 EQVVQA 1113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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