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Conserved domains on  [gi|1039770060|ref|XP_017176062|]
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volume-regulated anion channel subunit LRRC8C isoform X1 [Mus musculus]

Protein Classification

Pannexin_like and LRR domain-containing protein( domain architecture ID 12117038)

Pannexin_like and LRR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-338 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


:

Pssm-ID: 463622  Cd Length: 345  Bit Score: 590.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060   1 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQPAQNHSSVPNVSQAvISTTP 80
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLDDSYANS-LSPTQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060  81 LPPPKPSPTNPATVEMKGLKTDLDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFIS 160
Cdd:pfam12534  80 SAPTVSSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 161 ILGKCFDSPWTTRALSEVSGEDSEEKD--NRKNNMN-----RSGTIQSGPEGNLVRSQSLKSIPEKFVVD-KSAAGALDK 232
Cdd:pfam12534 160 ILGKCFDSPWTTRALSETSGEDSEEKKqrLEGNTVLpkvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDK 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 233 KEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTM 312
Cdd:pfam12534 240 KEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNL 319

                         330       340
                  ....*....|....*....|....*.
gi 1039770060 313 AHLFSKLSFCYLCFVSIYGLTCLYTL 338
Cdd:pfam12534 320 AFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
582-772 5.67e-36

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 141.22  E-value: 5.67e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 582 LNNLKKMTNLTELELVHCDleriphAVFSLLSLQELDLKENNLKSIEEivSFQHLRKLTVLKLWYNSIAYIPEHIKKLTS 661
Cdd:COG4886    89 LTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 662 LERLFFSHNKVEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSL 741
Cdd:COG4886   161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1039770060 742 SVLsPKIGNLLFLSYLDIKGNHFEVLPPELG 772
Cdd:COG4886   241 TDL-PELGNLTNLEELDLSNNQLTDLPPLAN 270
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 512-622 6.05e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 6.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 512 GLRNLEELYLVGSLshdISKNVTLESLRDLKSLKILS--IKSNVSKI--PQAVVDVSSHLQKMCVHNDgtKLVMLNNLKK 587
Cdd:cd21340    66 NLVNLKKLYLGGNR---ISVVEGLENLTNLEELHIENqrLPPGEKLTfdPRSLAALSNSLRVLNISGN--NIDSLEPLAP 140

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1039770060 588 MTNLTELELVHCDLERIP---HAVFSLLSLQELDLKEN 622
Cdd:cd21340   141 LRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGN 178
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-338 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 590.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060   1 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQPAQNHSSVPNVSQAvISTTP 80
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLDDSYANS-LSPTQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060  81 LPPPKPSPTNPATVEMKGLKTDLDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFIS 160
Cdd:pfam12534  80 SAPTVSSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 161 ILGKCFDSPWTTRALSEVSGEDSEEKD--NRKNNMN-----RSGTIQSGPEGNLVRSQSLKSIPEKFVVD-KSAAGALDK 232
Cdd:pfam12534 160 ILGKCFDSPWTTRALSETSGEDSEEKKqrLEGNTVLpkvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDK 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 233 KEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTM 312
Cdd:pfam12534 240 KEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNL 319

                         330       340
                  ....*....|....*....|....*.
gi 1039770060 313 AHLFSKLSFCYLCFVSIYGLTCLYTL 338
Cdd:pfam12534 320 AFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
582-772 5.67e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 141.22  E-value: 5.67e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 582 LNNLKKMTNLTELELVHCDleriphAVFSLLSLQELDLKENNLKSIEEivSFQHLRKLTVLKLWYNSIAYIPEHIKKLTS 661
Cdd:COG4886    89 LTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 662 LERLFFSHNKVEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSL 741
Cdd:COG4886   161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1039770060 742 SVLsPKIGNLLFLSYLDIKGNHFEVLPPELG 772
Cdd:COG4886   241 TDL-PELGNLTNLEELDLSNNQLTDLPPLAN 270
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 441-777 4.83e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 69.88  E-value: 4.83e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 441 FEITELQSLK-LEIIKNVM---IPATIAQLDNLQELclhqcsvkihsaalsFLKENlkvlsvKFDDmrELPPWMYGLRNL 516
Cdd:PLN00113  230 YEIGGLTSLNhLDLVYNNLtgpIPSSLGNLKNLQYL---------------FLYQN------KLSG--PIPPSIFSLQKL 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 517 EELYLV-GSLSHDISknvtlESLRDLKSLKILSIKSN--VSKIPQAVVDVSsHLQKMCVHNDGTKLVMLNNLKKMTNLTE 593
Cdd:PLN00113  287 ISLDLSdNSLSGEIP-----ELVIQLQNLEILHLFSNnfTGKIPVALTSLP-RLQVLQLWSNKFSGEIPKNLGKHNNLTV 360

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 594 LELVHCDLE-RIPHAVFSLLSLQELDLKENNL-----KSIEEIVSFQHLR------------KLTVLKLWY-------NS 648
Cdd:PLN00113  361 LDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLegeipKSLGACRSLRRVRlqdnsfsgelpsEFTKLPLVYfldisnnNL 440

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 649 IAYIPEHIKKLTSLERLFFSHNKVEVLPSHLFLCNKIRYLDLSYNDIR-FIPPEIGVLQSLQYFSITCNKVES-LPDELY 726
Cdd:PLN00113  441 QGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGeIPDELS 520

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1039770060 727 FCKKLKTLKIGKNSLSVLSP-KIGNLLFLSYLDIKGNHFE-VLPPELGDCRAL 777
Cdd:PLN00113  521 SCKKLVSLDLSHNQLSGQIPaSFSEMPVLSQLDLSQNQLSgEIPKNLGNVESL 573
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 578-764 1.29e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.95  E-value: 1.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 578 KLVMLNNLKKMTNLTELELVHCDLERIPHaVFSLLSLQELDLKENNLKSIEeivSFQHLRKLTVLKLWYNSIAYIpEHIK 657
Cdd:cd21340    13 NITKIDNLSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIE---NLENLVNLKKLYLGGNRISVV-EGLE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 658 KLTSLERLFFSHNKvevLPSHLFLCNKIRYLDlsyndirfippeiGVLQSLQYFSITCNKVESLpDELYFCKKLKTLKIG 737
Cdd:cd21340    88 NLTNLEELHIENQR---LPPGEKLTFDPRSLA-------------ALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDAS 150

                         170       180       190
                  ....*....|....*....|....*....|
gi 1039770060 738 KN---SLSVLSPKIGNLLFLSYLDIKGNHF 764
Cdd:cd21340   151 NNqisDLEELLDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
589-649 1.50e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.50e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039770060 589 TNLTELELVHCDLERIPHAVFS-LLSLQELDLKENNLKSIEEiVSFQHLRKLTVLKLWYNSI 649
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 512-622 6.05e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 6.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 512 GLRNLEELYLVGSLshdISKNVTLESLRDLKSLKILS--IKSNVSKI--PQAVVDVSSHLQKMCVHNDgtKLVMLNNLKK 587
Cdd:cd21340    66 NLVNLKKLYLGGNR---ISVVEGLENLTNLEELHIENqrLPPGEKLTfdPRSLAALSNSLRVLNISGN--NIDSLEPLAP 140

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1039770060 588 MTNLTELELVHCDLERIP---HAVFSLLSLQELDLKEN 622
Cdd:cd21340   141 LRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGN 178
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 425-665 6.10e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 40.24  E-value: 6.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060  425 RLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELCLHQCSVKIH-SAALSFLKEnLKVLSVKFDDM 503
Cdd:PLN03210   615 KLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCSSLVElPSSIQYLNK-LEDLDMSRCEN 693

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060  504 RELPPWMYGLR---------------------NLEELYLVGSLSHDISKNVTLESLRDLKSLKILSIKSNVSKIPQA--V 560
Cdd:PLN03210   694 LEILPTGINLKslyrlnlsgcsrlksfpdistNISWLDLDETAIEEFPSNLRLENLDELILCEMKSEKLWERVQPLTplM 773

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060  561 VDVSSHLQKMCVHNDGTKLVMLNNLKKMTNLTELELVHC-DLERIPHAVfSLLSLQELDLKE-NNLKSIEEIVSfqhlrK 638
Cdd:PLN03210   774 TMLSPSLTRLFLSDIPSLVELPSSIQNLHKLEHLEIENCiNLETLPTGI-NLESLESLDLSGcSRLRTFPDIST-----N 847

                          250       260
                   ....*....|....*....|....*..
gi 1039770060  639 LTVLKLWYNSIAYIPEHIKKLTSLERL 665
Cdd:PLN03210   848 ISDLNLSRTGIEEVPWWIEKFSNLSFL 874
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-338 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 590.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060   1 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQPAQNHSSVPNVSQAvISTTP 80
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLDDSYANS-LSPTQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060  81 LPPPKPSPTNPATVEMKGLKTDLDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFIS 160
Cdd:pfam12534  80 SAPTVSSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 161 ILGKCFDSPWTTRALSEVSGEDSEEKD--NRKNNMN-----RSGTIQSGPEGNLVRSQSLKSIPEKFVVD-KSAAGALDK 232
Cdd:pfam12534 160 ILGKCFDSPWTTRALSETSGEDSEEKKqrLEGNTVLpkvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDK 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 233 KEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTM 312
Cdd:pfam12534 240 KEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNL 319

                         330       340
                  ....*....|....*....|....*.
gi 1039770060 313 AHLFSKLSFCYLCFVSIYGLTCLYTL 338
Cdd:pfam12534 320 AFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
582-772 5.67e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 141.22  E-value: 5.67e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 582 LNNLKKMTNLTELELVHCDleriphAVFSLLSLQELDLKENNLKSIEEivSFQHLRKLTVLKLWYNSIAYIPEHIKKLTS 661
Cdd:COG4886    89 LTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 662 LERLFFSHNKVEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSL 741
Cdd:COG4886   161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1039770060 742 SVLsPKIGNLLFLSYLDIKGNHFEVLPPELG 772
Cdd:COG4886   241 TDL-PELGNLTNLEELDLSNNQLTDLPPLAN 270
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
515-779 1.74e-31

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 127.74  E-value: 1.74e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 515 NLEELYLVGSLSHDISKNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCVHNDGTKLVMLNNLKKMTNLTEL 594
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 595 ELVHCDLerIPHAVFSLLSLQELDLKENNlksieeivSFQHLRKLTVLKLWYNSIAYIPEHIKKLTSLERLFFSHNKVEV 674
Cdd:COG4886    81 LLSLLLL--GLTDLGDLTNLTELDLSGNE--------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTD 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 675 LPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFL 754
Cdd:COG4886   151 LPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNL 230

                         250       260
                  ....*....|....*....|....*
gi 1039770060 755 SYLDIKGNHFEVLpPELGDCRALKR 779
Cdd:COG4886   231 ETLDLSNNQLTDL-PELGNLTNLEE 254
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
510-771 2.28e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 112.72  E-value: 2.28e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 510 MYGLRNLEELYLVGSLSHDISknvtlESLRDLKSLKILSIKSN-VSKIPqavvdvsshlqkmcvhndgtklvmlNNLKKM 588
Cdd:COG4886   109 LSNLTNLESLDLSGNQLTDLP-----EELANLTNLKELDLSNNqLTDLP-------------------------EPLGNL 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 589 TNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEivSFQHLRKLTVLKLWYNSIAYIPEHIKKLTSLERLFFS 668
Cdd:COG4886   159 TNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE--PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLS 236

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 669 HNKVEVLPShLFLCNKIRYLDLSYNDIRFIPPEIGvLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKI 748
Cdd:COG4886   237 NNQLTDLPE-LGNLTNLEELDLSNNQLTDLPPLAN-LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314

                         250       260
                  ....*....|....*....|...
gi 1039770060 749 GNLLFLSYLDIKGNHFEVLPPEL 771
Cdd:COG4886   315 ILLLLLTTLLLLLLLLKGLLVTL 337
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
356-758 7.27e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.85  E-value: 7.27e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 356 QETGIDDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSG 435
Cdd:COG4886     2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 436 LPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELCLHQCSVKIHSAALSFLKeNLKVLSVKFDDMRELPPWMYGLRN 515
Cdd:COG4886    82 LSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLT-NLKELDLSNNQLTDLPEPLGNLTN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 516 LEELYLVGSLSHDISknvtlESLRDLKSLKILSIKSN-VSKIPQAvvdvsshlqkmcvhndgtklvmlnnLKKMTNLTEL 594
Cdd:COG4886   161 LKSLDLSNNQLTDLP-----EELGNLTNLKELDLSNNqITDLPEP-------------------------LGNLTNLEEL 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 595 ELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIvsfQHLRKLTVLKLWYNSIAYIPEhIKKLTSLERLFFSHNKVEV 674
Cdd:COG4886   211 DLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPEL---GNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTD 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 675 LP-SHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLF 753
Cdd:COG4886   287 LKlKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLL 366


                  ....*
gi 1039770060 754 LSYLD 758
Cdd:COG4886   367 LTLGL 371
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 441-777 4.83e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 69.88  E-value: 4.83e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 441 FEITELQSLK-LEIIKNVM---IPATIAQLDNLQELclhqcsvkihsaalsFLKENlkvlsvKFDDmrELPPWMYGLRNL 516
Cdd:PLN00113  230 YEIGGLTSLNhLDLVYNNLtgpIPSSLGNLKNLQYL---------------FLYQN------KLSG--PIPPSIFSLQKL 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 517 EELYLV-GSLSHDISknvtlESLRDLKSLKILSIKSN--VSKIPQAVVDVSsHLQKMCVHNDGTKLVMLNNLKKMTNLTE 593
Cdd:PLN00113  287 ISLDLSdNSLSGEIP-----ELVIQLQNLEILHLFSNnfTGKIPVALTSLP-RLQVLQLWSNKFSGEIPKNLGKHNNLTV 360

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 594 LELVHCDLE-RIPHAVFSLLSLQELDLKENNL-----KSIEEIVSFQHLR------------KLTVLKLWY-------NS 648
Cdd:PLN00113  361 LDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLegeipKSLGACRSLRRVRlqdnsfsgelpsEFTKLPLVYfldisnnNL 440

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 649 IAYIPEHIKKLTSLERLFFSHNKVEVLPSHLFLCNKIRYLDLSYNDIR-FIPPEIGVLQSLQYFSITCNKVES-LPDELY 726
Cdd:PLN00113  441 QGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGeIPDELS 520

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1039770060 727 FCKKLKTLKIGKNSLSVLSP-KIGNLLFLSYLDIKGNHFE-VLPPELGDCRAL 777
Cdd:PLN00113  521 SCKKLVSLDLSHNQLSGQIPaSFSEMPVLSQLDLSQNQLSgEIPKNLGNVESL 573
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 543-795 8.60e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.09  E-value: 8.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 543 SLKILSIKSNV--SKIPQAVVDVSShLQKMCVHNDGTKLVMLNNLKKMTNLTELELVHCDLE-RIPHAVFSLLSLQELDL 619
Cdd:PLN00113  165 SLKVLDLGGNVlvGKIPNSLTNLTS-LEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDL 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 620 KENNLksIEEI-VSFQHLRKLTVLKLWYNSIA-YIPEHIKKLTSLERLFFSHNKVE-VLPSHLFLCNKIRYLDLSYNDIR 696
Cdd:PLN00113  244 VYNNL--TGPIpSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFT 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 697 -FIPPEIGVLQSLQYFSITCNKVE-SLPDELYFCKKLKTLKIGKNSLSVLSPKI----GNL----LFLSYLDIKgnhfev 766
Cdd:PLN00113  322 gKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGEIPEGlcssGNLfkliLFSNSLEGE------ 395

                         250       260
                  ....*....|....*....|....*....
gi 1039770060 767 LPPELGDCRALKRAGLvVEDALFETLPSD 795
Cdd:PLN00113  396 IPKSLGACRSLRRVRL-QDNSFSGELPSE 423
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 578-764 1.29e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.95  E-value: 1.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 578 KLVMLNNLKKMTNLTELELVHCDLERIPHaVFSLLSLQELDLKENNLKSIEeivSFQHLRKLTVLKLWYNSIAYIpEHIK 657
Cdd:cd21340    13 NITKIDNLSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIE---NLENLVNLKKLYLGGNRISVV-EGLE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 658 KLTSLERLFFSHNKvevLPSHLFLCNKIRYLDlsyndirfippeiGVLQSLQYFSITCNKVESLpDELYFCKKLKTLKIG 737
Cdd:cd21340    88 NLTNLEELHIENQR---LPPGEKLTFDPRSLA-------------ALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDAS 150

                         170       180       190
                  ....*....|....*....|....*....|
gi 1039770060 738 KN---SLSVLSPKIGNLLFLSYLDIKGNHF 764
Cdd:cd21340   151 NNqisDLEELLDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
589-649 1.50e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.50e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039770060 589 TNLTELELVHCDLERIPHAVFS-LLSLQELDLKENNLKSIEEiVSFQHLRKLTVLKLWYNSI 649
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
581-801 4.58e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.55  E-value: 4.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 581 MLNNLKKmtNLTELELVHCDLERIPHAVFSllSLQELDLKENNLKSIeeivsfqhlrkltvlklwynsiayiPEHIKklT 660
Cdd:PRK15370  172 MRDCLKN--NKTELRLKILGLTTIPACIPE--QITTLILDNNELKSL-------------------------PENLQ--G 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 661 SLERLFFSHNKVEVLPSHLflCNKIRYLDLSYNDIRFIPPEIGvlQSLQYFSITCNKVESLPDELyfCKKLKTLKIGKNS 740
Cdd:PRK15370  221 NIKTLYANSNQLTSIPATL--PDTIQEMELSINRITELPERLP--SALQSLDLFHNKISCLPENL--PEELRYLSVYDNS 294

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039770060 741 LSVLSPKIGNllFLSYLDIKGNHFEVLPPELgdcrALKRAGLVVEDALFETLPSDVREQMK 801
Cdd:PRK15370  295 IRTLPAHLPS--GITHLNVQSNSLTALPETL----PPGLKTLEAGENALTSLPASLPPELQ 349
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 603-778 7.55e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.93  E-value: 7.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 603 RIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWYNSIA-YIPEhiKKLTSLERLFFSHNKVE-VLPSHLF 680
Cdd:PLN00113   84 KISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTgSIPR--GSIPNLETLDLSNNMLSgEIPNDIG 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 681 LCNKIRYLDLSYNDIR-FIPPEIGVLQSLQYFSITCNK-VESLPDELYFCKKLKTLKIGKNSLSVLSPK-IGNLLFLSYL 757
Cdd:PLN00113  162 SFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLGYNNLSGEIPYeIGGLTSLNHL 241

                         170       180
                  ....*....|....*....|..
gi 1039770060 758 DIKGNHFE-VLPPELGDCRALK 778
Cdd:PLN00113  242 DLVYNNLTgPIPSSLGNLKNLQ 263
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 513-687 2.25e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.40  E-value: 2.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 513 LRNLEELYLvgslSH-DISKnvtLESLRDLKSLKILSIKSNvskipqavvdvsshlqkmcvhndgtKLVMLNNLKKMTNL 591
Cdd:cd21340    45 LTNLTHLYL----QNnQIEK---IENLENLVNLKKLYLGGN-------------------------RISVVEGLENLTNL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 592 TELelvHCDLERI---------PHAVFSLL-SLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWYNSIAYIPEHIKKLTS 661
Cdd:cd21340    93 EEL---HIENQRLppgekltfdPRSLAALSnSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDLLSSWPS 169

                         170       180
                  ....*....|....*....|....*.
gi 1039770060 662 LERLFFSHNKVevlpshlflCNKIRY 687
Cdd:cd21340   170 LRELDLTGNPV---------CKKPKY 186
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 582-743 4.17e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 50.17  E-value: 4.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 582 LNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNL--KSIEEIVS-FQHLRKLTVLKLWYNSI-----AYIP 653
Cdd:COG5238   178 QNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIgdEGAEILAEaLKGNKSLTTLDLSNNQIgdegvIALA 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 654 EHIKKLTSLERLFFSHNKVEV-----LPSHLFLCNKIRYLDLSYNDIRFiPPEIGVLQSLQ-----------YFSITCNK 717
Cdd:COG5238   258 EALKNNTTVETLYLSGNQIGAegaiaLAKALQGNTTLTSLDLSVNRIGD-EGAIALAEGLQgnktlhtlnlaYNGIGAQG 336

                         170       180
                  ....*....|....*....|....*.
gi 1039770060 718 VESLPDELYFCKKLKTLKIGKNSLSV 743
Cdd:COG5238   337 AIALAKALQENTTLHSLDLSDNQIGD 362
LRR_8 pfam13855
Leucine rich repeat;
613-672 1.37e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 1.37e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039770060 613 SLQELDLKENNLKSIEEiVSFQHLRKLTVLKLWYNSIAYI-PEHIKKLTSLERLFFSHNKV 672
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDD-GAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
706-764 7.75e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 7.75e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039770060 706 QSLQYFSITCNKVESLPDE-LYFCKKLKTLKIGKNSLSVLSPK-IGNLLFLSYLDIKGNHF 764
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 590-695 8.16e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.34  E-value: 8.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 590 NLTELELVHCDL-----ERIPHAVFSLLSLQELDLKENNLKS--IEEI-VSFQHLRKLTVLKLWYNSI-----AYIPEHI 656
Cdd:cd00116   138 ALEKLVLGRNRLegascEALAKALRANRDLKELNLANNGIGDagIRALaEGLKANCNLEVLDLNNNGLtdegaSALAETL 217

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1039770060 657 KKLTSLERLFFSHNKV------EVLPSHLFLCNKIRYLDLSYNDI 695
Cdd:cd00116   218 ASLKSLEVLNLGDNNLtdagaaALASALLSPNISLLTLSLSCNDI 262
PLN03150 PLN03150
hypothetical protein; Provisional
 604-670 8.69e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.88  E-value: 8.69e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039770060 604 IPHAVFSLLSLQELDLKENNLKSieEI-VSFQHLRKLTVLKLWYNSI-AYIPEHIKKLTSLERLFFSHN 670
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRG--NIpPSLGSITSLEVLDLSYNSFnGSIPESLGQLTSLRILNLNGN 500
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 512-622 6.05e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 6.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060 512 GLRNLEELYLVGSLshdISKNVTLESLRDLKSLKILS--IKSNVSKI--PQAVVDVSSHLQKMCVHNDgtKLVMLNNLKK 587
Cdd:cd21340    66 NLVNLKKLYLGGNR---ISVVEGLENLTNLEELHIENqrLPPGEKLTfdPRSLAALSNSLRVLNISGN--NIDSLEPLAP 140

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1039770060 588 MTNLTELELVHCDLERIP---HAVFSLLSLQELDLKEN 622
Cdd:cd21340   141 LRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGN 178
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 425-665 6.10e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 40.24  E-value: 6.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060  425 RLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELCLHQCSVKIH-SAALSFLKEnLKVLSVKFDDM 503
Cdd:PLN03210   615 KLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCSSLVElPSSIQYLNK-LEDLDMSRCEN 693

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060  504 RELPPWMYGLR---------------------NLEELYLVGSLSHDISKNVTLESLRDLKSLKILSIKSNVSKIPQA--V 560
Cdd:PLN03210   694 LEILPTGINLKslyrlnlsgcsrlksfpdistNISWLDLDETAIEEFPSNLRLENLDELILCEMKSEKLWERVQPLTplM 773

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770060  561 VDVSSHLQKMCVHNDGTKLVMLNNLKKMTNLTELELVHC-DLERIPHAVfSLLSLQELDLKE-NNLKSIEEIVSfqhlrK 638
Cdd:PLN03210   774 TMLSPSLTRLFLSDIPSLVELPSSIQNLHKLEHLEIENCiNLETLPTGI-NLESLESLDLSGcSRLRTFPDIST-----N 847

                          250       260
                   ....*....|....*....|....*..
gi 1039770060  639 LTVLKLWYNSIAYIPEHIKKLTSLERL 665
Cdd:PLN03210   848 ISDLNLSRTGIEEVPWWIEKFSNLSFL 874
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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