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Conserved domains on  [gi|1039764033|ref|XP_017175001|]
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cornifin-B isoform X1 [Mus musculus]

Protein Classification

Cornifin domain-containing protein( domain architecture ID 12034798)

Cornifin domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cornifin pfam02389
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 4-135 6.13e-41

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


:

Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 132.87  E-value: 6.13e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764033   4 HQQKQPCTAPPQ-LHEQQVKQPCQPPPPEPCVSQVKTPCDTKAPEPCHPKAPEPCHPKAPEPCHPKAPEPCHPKAPEPCH 82
Cdd:pfam02389   3 QQVKQPCQPPPQePCVPTTKEPCHSKVPEPCNPKVPEPCCPKVPEPCCPKVPEPCCPKVPEPCCPKVPEPCYPKVPEPCS 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1039764033  83 PKAPEPCHPKAPEPCHPKVPEPCLPKAPEPCQPIVPEPCPSTVTPILAQQKTK 135
Cdd:pfam02389  83 PKVPEPCHPKAPEPCHPKVPEPCYPKAPEPCQPKVPEPCPSTVTPGPAQQKTK 135
 
Name Accession Description Interval E-value
Cornifin pfam02389
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 4-135 6.13e-41

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 132.87  E-value: 6.13e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764033   4 HQQKQPCTAPPQ-LHEQQVKQPCQPPPPEPCVSQVKTPCDTKAPEPCHPKAPEPCHPKAPEPCHPKAPEPCHPKAPEPCH 82
Cdd:pfam02389   3 QQVKQPCQPPPQePCVPTTKEPCHSKVPEPCNPKVPEPCCPKVPEPCCPKVPEPCCPKVPEPCCPKVPEPCYPKVPEPCS 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1039764033  83 PKAPEPCHPKAPEPCHPKVPEPCLPKAPEPCQPIVPEPCPSTVTPILAQQKTK 135
Cdd:pfam02389  83 PKVPEPCHPKAPEPCHPKVPEPCYPKAPEPCQPKVPEPCPSTVTPGPAQQKTK 135
PRK15313 PRK15313
intestinal colonization autotransporter adhesin MisL;
47-119 9.17e-11

intestinal colonization autotransporter adhesin MisL;


Pssm-ID: 237940 [Multi-domain]  Cd Length: 955  Bit Score: 58.27  E-value: 9.17e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039764033  47 EPCHPKAPEPCHPKAPEPCHPKA--PEPCHPKAPEPCHPKAPEPcHPKAPEPCHPKVPEPCLPKAPEPCQPIVPE 119
Cdd:PRK15313  559 EPDEPIIPDPVDPVIPDPVIPDPvdPDPVDPVIPDPVIPDPVDP-DPVDPEPVDPVIPDPTIPDIGQSDTPPITE 632
 
Name Accession Description Interval E-value
Cornifin pfam02389
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 4-135 6.13e-41

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 132.87  E-value: 6.13e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764033   4 HQQKQPCTAPPQ-LHEQQVKQPCQPPPPEPCVSQVKTPCDTKAPEPCHPKAPEPCHPKAPEPCHPKAPEPCHPKAPEPCH 82
Cdd:pfam02389   3 QQVKQPCQPPPQePCVPTTKEPCHSKVPEPCNPKVPEPCCPKVPEPCCPKVPEPCCPKVPEPCCPKVPEPCYPKVPEPCS 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1039764033  83 PKAPEPCHPKAPEPCHPKVPEPCLPKAPEPCQPIVPEPCPSTVTPILAQQKTK 135
Cdd:pfam02389  83 PKVPEPCHPKAPEPCHPKVPEPCYPKAPEPCQPKVPEPCPSTVTPGPAQQKTK 135
PRK15313 PRK15313
intestinal colonization autotransporter adhesin MisL;
47-119 9.17e-11

intestinal colonization autotransporter adhesin MisL;


Pssm-ID: 237940 [Multi-domain]  Cd Length: 955  Bit Score: 58.27  E-value: 9.17e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039764033  47 EPCHPKAPEPCHPKAPEPCHPKA--PEPCHPKAPEPCHPKAPEPcHPKAPEPCHPKVPEPCLPKAPEPCQPIVPE 119
Cdd:PRK15313  559 EPDEPIIPDPVDPVIPDPVIPDPvdPDPVDPVIPDPVIPDPVDP-DPVDPEPVDPVIPDPTIPDIGQSDTPPITE 632
PRK15313 PRK15313
intestinal colonization autotransporter adhesin MisL;
55-134 1.81e-09

intestinal colonization autotransporter adhesin MisL;


Pssm-ID: 237940 [Multi-domain]  Cd Length: 955  Bit Score: 54.42  E-value: 1.81e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764033  55 EPCHPKAPEPCHPKAPEPCHPKapepchPKAPEPCHPKAPEPCHPKVPEPClPKAPEPCQPIVPEPcpstVTPILAQQKT 134
Cdd:PRK15313  559 EPDEPIIPDPVDPVIPDPVIPD------PVDPDPVDPVIPDPVIPDPVDPD-PVDPEPVDPVIPDP----TIPDIGQSDT 627
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 42-128 6.81e-05

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 41.41  E-value: 6.81e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764033   42 DTKAPEPCHPKAPEPCHPKAPEPcHPKAPEPCHPKAPEPCHPKAPEPCHPKAPEPCHPKVPEPCLPKAPEPCQPIVPEPC 121
Cdd:PRK12270    35 DYGPGSTAAPTAAAAAAAAAASA-PAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAV 113


                   ....*..
gi 1039764033  122 PSTVTPI 128
Cdd:PRK12270   114 EDEVTPL 120
PRK15313 PRK15313
intestinal colonization autotransporter adhesin MisL;
37-103 6.61e-04

intestinal colonization autotransporter adhesin MisL;


Pssm-ID: 237940 [Multi-domain]  Cd Length: 955  Bit Score: 38.63  E-value: 6.61e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039764033  37 VKTPCDtkaPEPCHPKAPEPCHPKAPEPcHPKAPEPCHPKAPEPCHPKAPEPCHPKAPEpcHPKVPE 103
Cdd:PRK15313  578 IPDPVD---PDPVDPVIPDPVIPDPVDP-DPVDPEPVDPVIPDPTIPDIGQSDTPPITE--HQFRPE 638
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 37-129 1.03e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 37.76  E-value: 1.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764033   37 VKTPCDTKAPEPCHPKAPEPCHPKAP--EPCHPKAPEP--CHPKAPEPCHPKAPEPCHPKAPEPCHPKVPEPCLPKAP-- 110
Cdd:PRK10263   752 VQQPQQPVAPQQQYQQPQQPVAPQPQyqQPQQPVAPQPqyQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQyq 831

                           90
                   ....*....|....*....
gi 1039764033  111 EPCQPIVPEPCPSTVTPIL 129
Cdd:PRK10263   832 QPQQPVAPQPQDTLLHPLL 850
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 51-128 3.64e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 36.33  E-value: 3.64e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039764033  51 PKAPEPCHPKAPEPChPKAPEPCHPKAPEPCHPKAPEPCHPKaPEPCHPKVPEPCLPKAPEPCQPIVPEPCPSTVTPI 128
Cdd:PRK14950  363 VPAPQPAKPTAAAPS-PVRPTPAPSTRPKAAAAANIPPKEPV-RETATPPPVPPRPVAPPVPHTPESAPKLTRAAIPV 438
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 40-101 5.39e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 35.64  E-value: 5.39e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039764033   40 PCDTKAPEPCHPKAPEPCHPKAPEPCHPKAPEPCHPKAPEPCHPKAPEPCHPKAPEPCHPKV 101
Cdd:PRK12270    56 SAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVEDEV 117
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 38-132 6.36e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 35.46  E-value: 6.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764033  38 KTPCDTKAPEPCHPKAPEPCHPKAPEPCHPKA-------PEPCHPKAPEPCHPKAPEPCHPKAPEPCHPKvPEPCLPKAP 110
Cdd:PRK14951  379 KTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAasapaapPAAAPPAPVAAPAAAAPAAAPAAAPAAVALA-PAPPAQAAP 457

                          90       100
                  ....*....|....*....|....*
gi 1039764033 111 EPCQPIV---PEPCPSTVTPILAQQ 132
Cdd:PRK14951  458 ETVAIPVrvaPEPAVASAAPAPAAA 482
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 45-131 9.25e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 35.17  E-value: 9.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764033  45 APEPCHPKAPEPChPKAPEPCHPKAPEPCHPKAPEPCHPKApepcHPKAPEPCHPKVPEPCLPKAPEPCQPIVPEPCPST 124
Cdd:PRK14950  365 APQPAKPTAAAPS-PVRPTPAPSTRPKAAAAANIPPKEPVR----ETATPPPVPPRPVAPPVPHTPESAPKLTRAAIPVD 439


                  ....*..
gi 1039764033 125 VTPILAQ 131
Cdd:PRK14950  440 EKPKYTP 446
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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