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Conserved domains on  [gi|1039751438|ref|XP_017172557|]
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structure-specific endonuclease subunit SLX4 isoform X11 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SAP_SLX4 cd22999
SAP domain of structure-specific endonuclease subunit SLX4 and similar proteins; SLX4, also ...
 666-715 1.07e-20

SAP domain of structure-specific endonuclease subunit SLX4 and similar proteins; SLX4, also called BTB/POZ domain-containing protein 12 (BTBD12), is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases and is required for DNA repair. Mutations in the SLX4 gene are found in Fanconi anemia. This model corresponds to a conserved region called the SAP domain, which is responsible for the binding of MUS81, which plays a distinct role in interstrand crosslink repair.


:

Pssm-ID: 439380 [Multi-domain]  Cd Length: 51  Bit Score: 86.08  E-value: 1.07e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1039751438 666 PKVPITPMPRYSIMETPVLKKELDRFGVRALPKRQMVLKLKEIFQYTHQT 715
Cdd:cd22999     1 KPSPVTPMPDYESMTTPELKKELKKYGFKPLPRKKMIALLEEIWEQTHPY 50
Slx4 pfam09494
Slx4 endonuclease; The Slx4 protein is a heteromeric structure-specific endonuclease found ...
 820-877 2.03e-14

Slx4 endonuclease; The Slx4 protein is a heteromeric structure-specific endonuclease found from fungi to mammals. Slx4 with Slx1 acts as a nuclease on branched DNA substrates, particularly simple-Y, 5'-flap, or replication fork structures by cleaving the strand bearing the 5' non-homologous arm at the branch junction and thus generating ligatable nicked products from 5'-flap or replication fork substrates.


:

Pssm-ID: 430644  Cd Length: 60  Bit Score: 68.30  E-value: 2.03e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751438 820 EEAVRRYIRSKPALHRQVLRYQPVELAELQAELKQNG--IPVAMGKLSDILDAQCITFTT 877
Cdd:pfam09494   1 FEAITELIKSDPSLYEKILTYEPIVLEDLTAWLNEGGflIEVDPGTLKEWCDSQGICFTN 60
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 518-767 1.31e-04

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 45.84  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751438 518 EVGDSDDEVASHQGNS----SPVLDGDPPGPMGDYcwnEPlSPIPIdhLNLERTGPLTTSSPSsqvlealhsdDCHSPGL 593
Cdd:PTZ00449  533 EHEDSKESDEPKEGGKpgetKEGEVGKKPGPAKEH---KP-SKIPT--LSKKPEFPKDPKHPK----------DPEEPKK 596

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751438 594 GTTPIRGSCGTLRESQERSSLAGSPEAlwdDWNEEEGQSPEAPPVAQmlstRTRKPDRPETPKGANQKKnlPPKVPITPM 673
Cdd:PTZ00449  597 PKRPRSAQRPTRPKSPKLPELLDIPKS---PKRPESPKSPKRPPPPQ----RPSSPERPEGPKIIKSPK--PPKSPKPPF 667

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751438 674 prysimeTPVLKKEL-DRFGVRALPKRQMVLKLKEIFQYTHQTLESDSEDEVQSPQIPAELPCRQASTTE-TCNPSRLPT 751
Cdd:PTZ00449  668 -------DPKFKEKFyDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLPRDEEfPFEPIGDPD 740

                         250
                  ....*....|....*.
gi 1039751438 752 GEPSHPDGDAQLPASQ 767
Cdd:PTZ00449  741 AEQPDDIEFFTPPEEE 756
 
Name Accession Description Interval E-value
SAP_SLX4 cd22999
SAP domain of structure-specific endonuclease subunit SLX4 and similar proteins; SLX4, also ...
 666-715 1.07e-20

SAP domain of structure-specific endonuclease subunit SLX4 and similar proteins; SLX4, also called BTB/POZ domain-containing protein 12 (BTBD12), is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases and is required for DNA repair. Mutations in the SLX4 gene are found in Fanconi anemia. This model corresponds to a conserved region called the SAP domain, which is responsible for the binding of MUS81, which plays a distinct role in interstrand crosslink repair.


Pssm-ID: 439380 [Multi-domain]  Cd Length: 51  Bit Score: 86.08  E-value: 1.07e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1039751438 666 PKVPITPMPRYSIMETPVLKKELDRFGVRALPKRQMVLKLKEIFQYTHQT 715
Cdd:cd22999     1 KPSPVTPMPDYESMTTPELKKELKKYGFKPLPRKKMIALLEEIWEQTHPY 50
Slx4 pfam09494
Slx4 endonuclease; The Slx4 protein is a heteromeric structure-specific endonuclease found ...
 820-877 2.03e-14

Slx4 endonuclease; The Slx4 protein is a heteromeric structure-specific endonuclease found from fungi to mammals. Slx4 with Slx1 acts as a nuclease on branched DNA substrates, particularly simple-Y, 5'-flap, or replication fork structures by cleaving the strand bearing the 5' non-homologous arm at the branch junction and thus generating ligatable nicked products from 5'-flap or replication fork substrates.


Pssm-ID: 430644  Cd Length: 60  Bit Score: 68.30  E-value: 2.03e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751438 820 EEAVRRYIRSKPALHRQVLRYQPVELAELQAELKQNG--IPVAMGKLSDILDAQCITFTT 877
Cdd:pfam09494   1 FEAITELIKSDPSLYEKILTYEPIVLEDLTAWLNEGGflIEVDPGTLKEWCDSQGICFTN 60
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 518-767 1.31e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 45.84  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751438 518 EVGDSDDEVASHQGNS----SPVLDGDPPGPMGDYcwnEPlSPIPIdhLNLERTGPLTTSSPSsqvlealhsdDCHSPGL 593
Cdd:PTZ00449  533 EHEDSKESDEPKEGGKpgetKEGEVGKKPGPAKEH---KP-SKIPT--LSKKPEFPKDPKHPK----------DPEEPKK 596

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751438 594 GTTPIRGSCGTLRESQERSSLAGSPEAlwdDWNEEEGQSPEAPPVAQmlstRTRKPDRPETPKGANQKKnlPPKVPITPM 673
Cdd:PTZ00449  597 PKRPRSAQRPTRPKSPKLPELLDIPKS---PKRPESPKSPKRPPPPQ----RPSSPERPEGPKIIKSPK--PPKSPKPPF 667

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751438 674 prysimeTPVLKKEL-DRFGVRALPKRQMVLKLKEIFQYTHQTLESDSEDEVQSPQIPAELPCRQASTTE-TCNPSRLPT 751
Cdd:PTZ00449  668 -------DPKFKEKFyDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLPRDEEfPFEPIGDPD 740

                         250
                  ....*....|....*.
gi 1039751438 752 GEPSHPDGDAQLPASQ 767
Cdd:PTZ00449  741 AEQPDDIEFFTPPEEE 756
 
Name Accession Description Interval E-value
SAP_SLX4 cd22999
SAP domain of structure-specific endonuclease subunit SLX4 and similar proteins; SLX4, also ...
 666-715 1.07e-20

SAP domain of structure-specific endonuclease subunit SLX4 and similar proteins; SLX4, also called BTB/POZ domain-containing protein 12 (BTBD12), is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases and is required for DNA repair. Mutations in the SLX4 gene are found in Fanconi anemia. This model corresponds to a conserved region called the SAP domain, which is responsible for the binding of MUS81, which plays a distinct role in interstrand crosslink repair.


Pssm-ID: 439380 [Multi-domain]  Cd Length: 51  Bit Score: 86.08  E-value: 1.07e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1039751438 666 PKVPITPMPRYSIMETPVLKKELDRFGVRALPKRQMVLKLKEIFQYTHQT 715
Cdd:cd22999     1 KPSPVTPMPDYESMTTPELKKELKKYGFKPLPRKKMIALLEEIWEQTHPY 50
Slx4 pfam09494
Slx4 endonuclease; The Slx4 protein is a heteromeric structure-specific endonuclease found ...
 820-877 2.03e-14

Slx4 endonuclease; The Slx4 protein is a heteromeric structure-specific endonuclease found from fungi to mammals. Slx4 with Slx1 acts as a nuclease on branched DNA substrates, particularly simple-Y, 5'-flap, or replication fork structures by cleaving the strand bearing the 5' non-homologous arm at the branch junction and thus generating ligatable nicked products from 5'-flap or replication fork substrates.


Pssm-ID: 430644  Cd Length: 60  Bit Score: 68.30  E-value: 2.03e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751438 820 EEAVRRYIRSKPALHRQVLRYQPVELAELQAELKQNG--IPVAMGKLSDILDAQCITFTT 877
Cdd:pfam09494   1 FEAITELIKSDPSLYEKILTYEPIVLEDLTAWLNEGGflIEVDPGTLKEWCDSQGICFTN 60
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 518-767 1.31e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 45.84  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751438 518 EVGDSDDEVASHQGNS----SPVLDGDPPGPMGDYcwnEPlSPIPIdhLNLERTGPLTTSSPSsqvlealhsdDCHSPGL 593
Cdd:PTZ00449  533 EHEDSKESDEPKEGGKpgetKEGEVGKKPGPAKEH---KP-SKIPT--LSKKPEFPKDPKHPK----------DPEEPKK 596

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751438 594 GTTPIRGSCGTLRESQERSSLAGSPEAlwdDWNEEEGQSPEAPPVAQmlstRTRKPDRPETPKGANQKKnlPPKVPITPM 673
Cdd:PTZ00449  597 PKRPRSAQRPTRPKSPKLPELLDIPKS---PKRPESPKSPKRPPPPQ----RPSSPERPEGPKIIKSPK--PPKSPKPPF 667

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751438 674 prysimeTPVLKKEL-DRFGVRALPKRQMVLKLKEIFQYTHQTLESDSEDEVQSPQIPAELPCRQASTTE-TCNPSRLPT 751
Cdd:PTZ00449  668 -------DPKFKEKFyDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLPRDEEfPFEPIGDPD 740

                         250
                  ....*....|....*.
gi 1039751438 752 GEPSHPDGDAQLPASQ 767
Cdd:PTZ00449  741 AEQPDDIEFFTPPEEE 756
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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