SETD4 family SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain-containing protein similar to the SET domain region of Homo sapiens SET domain-containing protein 4 (SETD4), a histone-lysine N-methyltransferase that acts as a regulator of cell proliferation, cell differentiation and inflammatory response
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a ...
49-241
1.39e-74
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a cytosolic and nuclear functional lysine methyltransferase that plays a crucial role in breast carcinogenesis. However, its specific substrates and modification sites remain to be disclosed.
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Pssm-ID: 380954 [Multi-domain] Cd Length: 245 Bit Score: 227.57 E-value: 1.39e-74
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a ...
49-241
1.39e-74
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a cytosolic and nuclear functional lysine methyltransferase that plays a crucial role in breast carcinogenesis. However, its specific substrates and modification sites remain to be disclosed.
Pssm-ID: 380954 [Multi-domain] Cd Length: 245 Bit Score: 227.57 E-value: 1.39e-74
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a ...
49-241
1.39e-74
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a cytosolic and nuclear functional lysine methyltransferase that plays a crucial role in breast carcinogenesis. However, its specific substrates and modification sites remain to be disclosed.
Pssm-ID: 380954 [Multi-domain] Cd Length: 245 Bit Score: 227.57 E-value: 1.39e-74
SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; ...
52-239
2.72e-41
SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; Rubisco LSMT is a non-histone protein methyl transferase responsible for the trimethylation of lysine14 in the large subunit of Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase). The family also includes SET domain-containing proteins, SETD3, SETD4 and SETD6, which belong to methyltransferase class VII that represents classical non-histone SET domain methyltransferases. Members in this family contain a SET domain and a C-terminal RubisCO LSMT substrate-binding (Rubis-subs-bind) domain.
Pssm-ID: 380925 [Multi-domain] Cd Length: 236 Bit Score: 141.82 E-value: 2.72e-41
SET domain found in chloroplastic ribulose-1,5 bisphosphate carboxylase/oxygenase large ...
58-240
1.20e-27
SET domain found in chloroplastic ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase (RBCMT) and similar proteins; RBCMT (EC 2.1.1.127; also termed [Ribulose-bisphosphate carboxylase]-lysine N-methyltransferase, RuBisCO LSMT, RuBisCO methyltransferase, or rbcMT) methylates 'Lys-14' of the large subunit of RuBisCO.
Pssm-ID: 380956 Cd Length: 237 Bit Score: 106.24 E-value: 1.20e-27
SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins; SETD3 (EC 2. ...
34-240
1.98e-25
SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins; SETD3 (EC 2.1.1.43) is a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3 (H3K4me and H3K36me). It functions as a transcriptional activator that plays an important role in the transcriptional regulation of muscle cell differentiation via interaction with MYOD1.
Pssm-ID: 380953 Cd Length: 251 Bit Score: 100.79 E-value: 1.98e-25
SET domain found in Schizosaccharomyces pombe SET domain-containing protein 10 (SETD10) and ...
55-238
5.06e-19
SET domain found in Schizosaccharomyces pombe SET domain-containing protein 10 (SETD10) and similar proteins; Schizosaccharomyces pombe SETD10 is a ribosomal S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates ribosomal protein L23 (rpl23a and rpl23b).
Pssm-ID: 380957 Cd Length: 252 Bit Score: 83.54 E-value: 5.06e-19
SET domain found in SET domain-containing protein 6 (SETD6) and similar proteins; SETD6 is a ...
57-134
1.09e-03
SET domain found in SET domain-containing protein 6 (SETD6) and similar proteins; SETD6 is a lysine N-methyltransferase that monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity. It also monomethylates 'Lys-8' of H2AZ (H2AZK8me1).
Pssm-ID: 380955 [Multi-domain] Cd Length: 250 Bit Score: 39.60 E-value: 1.09e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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(labeled illustration) Four types of hits can be shown, as available,
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and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
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