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Conserved domains on  [gi|1039749072|ref|XP_017172156|]
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sperm flagellar protein 2 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NK super family cl17190
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 2-186 3.89e-14

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


The actual alignment was detected with superfamily member cd01428:

Pssm-ID: 450170 [Multi-domain]  Cd Length: 194  Bit Score: 72.65  E-value: 3.89e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749072    2 RAQLGAKSEL------MLRRGKSIPDILLVSILVNAIKEIPVDQSWVLDGFPITLNQAKLLEEALTGYKRkflqlkkkke 75
Cdd:cd01428     35 REEIASGTELgkkakeYIDSGKLVPDEIVIKLLKERLKKPDCKKGFILDGFPRTVDQAEALDELLDEGIK---------- 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749072   76 qmptlaldpststevsllpsaLDFVILLDISDNSS----LARTNDIIAKEISHEISHENVGRPGTGTSQDNKSEdrnlrd 151
Cdd:cd01428    105 ---------------------PDKVIELDVPDEVLieriLGRRICPVSGRVYHLGKDDVTGEPLSQRSDDNEET------ 157

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1039749072  152 hIQHRIVGFLDN-WPLLEewFTQPKNILTKVNAEID 186
Cdd:cd01428    158 -IKKRLEVYKEQtAPLID--YYKKKGKLVEIDGSGD 190
ZnF_TTF super family cl02692
zinc finger in transposases and transcription factors;
821-886 2.05e-05

zinc finger in transposases and transcription factors;


The actual alignment was detected with superfamily member smart00597:

Pssm-ID: 214739  Cd Length: 91  Bit Score: 44.40  E-value: 2.05e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749072   821 FLKIWLKKYP-WLVYDEQLNLMFCVLCRK-HGVTSGGSTVSFLYGTDNFRAE--FLSAHHLSEAHAKASL 886
Cdd:smart00597    5 FQKSWFHQFPdWLEYSVEKDAAFCKYCYLfRPGRDGGSDLFVTEGFCSWKKEriRLKQHEVSKRHRNARL 74
 
Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 2-186 3.89e-14

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 72.65  E-value: 3.89e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749072    2 RAQLGAKSEL------MLRRGKSIPDILLVSILVNAIKEIPVDQSWVLDGFPITLNQAKLLEEALTGYKRkflqlkkkke 75
Cdd:cd01428     35 REEIASGTELgkkakeYIDSGKLVPDEIVIKLLKERLKKPDCKKGFILDGFPRTVDQAEALDELLDEGIK---------- 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749072   76 qmptlaldpststevsllpsaLDFVILLDISDNSS----LARTNDIIAKEISHEISHENVGRPGTGTSQDNKSEdrnlrd 151
Cdd:cd01428    105 ---------------------PDKVIELDVPDEVLieriLGRRICPVSGRVYHLGKDDVTGEPLSQRSDDNEET------ 157

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1039749072  152 hIQHRIVGFLDN-WPLLEewFTQPKNILTKVNAEID 186
Cdd:cd01428    158 -IKKRLEVYKEQtAPLID--YYKKKGKLVEIDGSGD 190
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 1-187 1.92e-08

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 56.29  E-value: 1.92e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749072    1 MRAQLGAKSEL------MLRRGKSIPDILLVSILVNAIKEIPVDQSWVLDGFPITLNQAKLLEEALTGYKRKflqlkkkk 74
Cdd:COG0563     35 LRAAVKAGTELgkkakeYMDAGELVPDEIVIGLVKERLAQPDCANGFILDGFPRTVAQAEALDELLAELGIK-------- 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749072   75 eqmptlaldpststevsllpsaLDFVILLDISDNSSLARtndiiakeISHEISHENVGRPGTGTSQDNKSEDRNLRDH-- 152
Cdd:COG0563    107 ----------------------LDAVIELDVDDEELVER--------LSGRRVCPNCGATYHVKFNPPKVEGVCDKCGge 156

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1039749072  153 -----------IQHRIVGFLDN-WPLLEewFTQPKNILTKVNAE--IDE 187
Cdd:COG0563    157 lvqraddneetVRKRLEVYHEQtAPLID--YYRKKGKLVEIDGEgsIEE 203
ADK pfam00406
Adenylate kinase;
1-133 6.10e-07

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 51.16  E-value: 6.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749072    1 MRAQLGAKSEL------MLRRGKSIPDILLVSILVNAIKEIPVDQSWVLDGFPITLNQAKLLEEALTgYKRKflqlkkkk 74
Cdd:pfam00406   31 LRAEIKSGTELgkeakeYMDKGELVPDEVVVGLVKERLEQNDCKNGFLLDGFPRTVPQAEALEELLE-RGIK-------- 101

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1039749072   75 eqmptlaldpststevsllpsaLDFVILLDISDnsslartnDIIAKEISHEISHENVGR 133
Cdd:pfam00406  102 ----------------------LDYVIEFDVPD--------EVLVERLTGRRIHPNSGR 130
ZnF_TTF smart00597
zinc finger in transposases and transcription factors;
821-886 2.05e-05

zinc finger in transposases and transcription factors;


Pssm-ID: 214739  Cd Length: 91  Bit Score: 44.40  E-value: 2.05e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749072   821 FLKIWLKKYP-WLVYDEQLNLMFCVLCRK-HGVTSGGSTVSFLYGTDNFRAE--FLSAHHLSEAHAKASL 886
Cdd:smart00597    5 FQKSWFHQFPdWLEYSVEKDAAFCKYCYLfRPGRDGGSDLFVTEGFCSWKKEriRLKQHEVSKRHRNARL 74
adk PRK00279
adenylate kinase; Reviewed
 2-113 2.16e-05

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 47.07  E-value: 2.16e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749072    2 RAQLGAKSELMLR------RGKSIPDILLVSILVNAIKEIPVDQSWVLDGFPITLNQAKLLEEALTGYKRKflqlkkkke 75
Cdd:PRK00279    36 RAAVKAGTELGKEaksymdAGELVPDEIVIGLVKERLAQPDCKNGFLLDGFPRTIPQAEALDEMLKELGIK--------- 106

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1039749072   76 qmptlaldpststevsllpsaLDFVILLDISDNSSLAR 113
Cdd:PRK00279   107 ---------------------LDAVIEIDVPDEELVER 123
 
Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 2-186 3.89e-14

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 72.65  E-value: 3.89e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749072    2 RAQLGAKSEL------MLRRGKSIPDILLVSILVNAIKEIPVDQSWVLDGFPITLNQAKLLEEALTGYKRkflqlkkkke 75
Cdd:cd01428     35 REEIASGTELgkkakeYIDSGKLVPDEIVIKLLKERLKKPDCKKGFILDGFPRTVDQAEALDELLDEGIK---------- 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749072   76 qmptlaldpststevsllpsaLDFVILLDISDNSS----LARTNDIIAKEISHEISHENVGRPGTGTSQDNKSEdrnlrd 151
Cdd:cd01428    105 ---------------------PDKVIELDVPDEVLieriLGRRICPVSGRVYHLGKDDVTGEPLSQRSDDNEET------ 157

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1039749072  152 hIQHRIVGFLDN-WPLLEewFTQPKNILTKVNAEID 186
Cdd:cd01428    158 -IKKRLEVYKEQtAPLID--YYKKKGKLVEIDGSGD 190
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 1-187 1.92e-08

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 56.29  E-value: 1.92e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749072    1 MRAQLGAKSEL------MLRRGKSIPDILLVSILVNAIKEIPVDQSWVLDGFPITLNQAKLLEEALTGYKRKflqlkkkk 74
Cdd:COG0563     35 LRAAVKAGTELgkkakeYMDAGELVPDEIVIGLVKERLAQPDCANGFILDGFPRTVAQAEALDELLAELGIK-------- 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749072   75 eqmptlaldpststevsllpsaLDFVILLDISDNSSLARtndiiakeISHEISHENVGRPGTGTSQDNKSEDRNLRDH-- 152
Cdd:COG0563    107 ----------------------LDAVIELDVDDEELVER--------LSGRRVCPNCGATYHVKFNPPKVEGVCDKCGge 156

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1039749072  153 -----------IQHRIVGFLDN-WPLLEewFTQPKNILTKVNAE--IDE 187
Cdd:COG0563    157 lvqraddneetVRKRLEVYHEQtAPLID--YYRKKGKLVEIDGEgsIEE 203
ADK pfam00406
Adenylate kinase;
1-133 6.10e-07

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 51.16  E-value: 6.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749072    1 MRAQLGAKSEL------MLRRGKSIPDILLVSILVNAIKEIPVDQSWVLDGFPITLNQAKLLEEALTgYKRKflqlkkkk 74
Cdd:pfam00406   31 LRAEIKSGTELgkeakeYMDKGELVPDEVVVGLVKERLEQNDCKNGFLLDGFPRTVPQAEALEELLE-RGIK-------- 101

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1039749072   75 eqmptlaldpststevsllpsaLDFVILLDISDnsslartnDIIAKEISHEISHENVGR 133
Cdd:pfam00406  102 ----------------------LDYVIEFDVPD--------EVLVERLTGRRIHPNSGR 130
ZnF_TTF smart00597
zinc finger in transposases and transcription factors;
821-886 2.05e-05

zinc finger in transposases and transcription factors;


Pssm-ID: 214739  Cd Length: 91  Bit Score: 44.40  E-value: 2.05e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749072   821 FLKIWLKKYP-WLVYDEQLNLMFCVLCRK-HGVTSGGSTVSFLYGTDNFRAE--FLSAHHLSEAHAKASL 886
Cdd:smart00597    5 FQKSWFHQFPdWLEYSVEKDAAFCKYCYLfRPGRDGGSDLFVTEGFCSWKKEriRLKQHEVSKRHRNARL 74
adk PRK00279
adenylate kinase; Reviewed
 2-113 2.16e-05

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 47.07  E-value: 2.16e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749072    2 RAQLGAKSELMLR------RGKSIPDILLVSILVNAIKEIPVDQSWVLDGFPITLNQAKLLEEALTGYKRKflqlkkkke 75
Cdd:PRK00279    36 RAAVKAGTELGKEaksymdAGELVPDEIVIGLVKERLAQPDCKNGFLLDGFPRTIPQAEALDEMLKELGIK--------- 106

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1039749072   76 qmptlaldpststevsllpsaLDFVILLDISDNSSLAR 113
Cdd:PRK00279   107 ---------------------LDAVIEIDVPDEELVER 123
PRK14531 PRK14531
adenylate kinase; Provisional
 1-83 6.42e-05

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 45.19  E-value: 6.42e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749072    1 MRAQLGAKSEL------MLRRGKSIPDILLVSILVNAIKEIPvDQSWVLDGFPITLNQAKLLEEALTgykrkflQLKKKK 74
Cdd:PRK14531    37 LRSEVAAGSALgqeaeaVMNRGELVSDALVLAIVESQLKALN-SGGWLLDGFPRTVAQAEALEPLLE-------ELKQPI 108


                   ....*....
gi 1039749072   75 EQMPTLALD 83
Cdd:PRK14531   109 EAVVLLELD 117
adk PRK02496
adenylate kinase; Provisional
 5-61 1.16e-04

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 44.74  E-value: 1.16e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039749072    5 LGAKSELMLRRGKSIPDILLVSILVNAIKEIPVDQSWVLDGFPITLNQAKLLEEALT 61
Cdd:PRK02496    46 LGIKAQGYMDKGELVPDQLVLDLVQERLQQPDAANGWILDGFPRKVTQAAFLDELLQ 102
PLN02674 PLN02674
adenylate kinase
 5-60 4.54e-04

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 43.72  E-value: 4.54e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039749072    5 LGAKSELMLRRGKSIPDILLVSILVNAIKEIPVDQSWVLDGFPITLNQAKLLEEAL 60
Cdd:PLN02674    76 LGIKAKEAMDKGELVSDDLVVGIIDEAMKKPSCQKGFILDGFPRTVVQAQKLDEML 131
PRK14526 PRK14526
adenylate kinase; Provisional
 5-64 1.47e-03

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 41.76  E-value: 1.47e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749072    5 LGAKSELMLRRGKSIPDILLVSILVNAIKEIPVDQSWVLDGFPITLNQAKLLEEALTGYK 64
Cdd:PRK14526    45 LGKEIKQIVENGQLVPDSITIKIVEDKINTIKNNDNFILDGFPRNINQAKALDKFLPNIK 104
PRK14528 PRK14528
adenylate kinase; Provisional
 5-182 2.31e-03

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 40.77  E-value: 2.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749072    5 LGAKSELMLRRGKSIPDILLVSILVNAIKEIPVDQSWVLDGFPITLNQAKLLEEALtgykrkflqlkkKKEQMptlaldp 84
Cdd:PRK14528    46 MGIEAKRYMDAGDLVPDSVVIGIIKDRIREADCKNGFLLDGFPRTVEQADALDALL------------KNEGK------- 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749072   85 ststevsllpsALDFVILLDISDNSSLARTNDIIAKEisheishenvgrpgtGTSQDNKSEDRNLRDHIQHRIVGFLDnw 164
Cdd:PRK14528   107 -----------SIDKAINLEVPDGELLKRLLGRAEIE---------------GRADDNEATIKNRLDNYNKKTLPLLD-- 158

                          170
                   ....*....|....*...
gi 1039749072  165 plleewFTQPKNILTKVN 182
Cdd:PRK14528   159 ------FYAAQKKLSQVN 170
PRK14529 PRK14529
adenylate kinase; Provisional
 4-60 6.53e-03

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 39.70  E-value: 6.53e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039749072    4 QLGAKSELMLRRGKSIPDILLVSILVNAIKEiPVDQSWVLDGFPITLNQAKLLEEAL 60
Cdd:PRK14529    44 ELGKKAKEYIDRGDLVPDDITIPMILETLKQ-DGKNGWLLDGFPRNKVQAEKLWEAL 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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