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Conserved domains on  [gi|1039745400|ref|XP_017171308|]
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voltage-dependent L-type calcium channel subunit alpha-1D isoform X16 [Mus musculus]

Protein Classification

Ca_chan_IQ domain-containing protein; Ca_chan_IQ domain-containing protein; voltage-dependent L-type calcium channel subunit alpha-1; voltage-dependent L-type calcium channel subunit alpha-1( domain architecture ID 11999372)

Ca_chan_IQ domain-containing protein; Ca_chan_IQ domain-containing protein; voltage-dependent L-type (Long-lasting) calcium channel subunit alpha-1 is part of a multisubunit voltage-dependent calcium channel that mediates the entry of calcium ions into excitable cells and is also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death; voltage-dependent L-type (Long-lasting) calcium channel subunit alpha-1 is part of a multisubunit voltage-dependent calcium channel that mediates the entry of calcium ions into excitable cells and is also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
125-417 2.45e-70

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 236.39  E-value: 2.45e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400  125 WKPFDIFILLAIFANCVALAIYIPFPEDDSnsTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHpnaYVRNGWNLLDFVI 204
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP--LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400  205 VIVGLFSVILeqltketeggnhsSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 284
Cdd:pfam00520   76 VLPSLISLVL-------------SSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFI 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400  285 YAIIGLELFIGKMHKtcffadsdivaeedpapcafsgngrqctangtecrsgWVGPNGGITNFDNFAFAMLTVFQCITME 364
Cdd:pfam00520  143 FAIIGYQLFGGKLKT-------------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTTE 185
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1039745400  365 GWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAK 417
Cdd:pfam00520  186 GWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
CAC1F_C super family cl25181
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1619-2135 4.26e-57

Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.


The actual alignment was detected with superfamily member pfam16885:

Pssm-ID: 465298 [Multi-domain]  Cd Length: 355  Bit Score: 202.54  E-value: 4.26e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400 1619 AGLRTLHDIGPEIRRAISCDLQDDEPEDSKPEEEDVFKRNgallgnhvnhvnsDRRDSLQQTNTTHRPLHVQRPSMPPAS 1698
Cdd:pfam16885    1 AGLRSLQDLGPEIRQALTCDTEEEEEEEEGQEGEEEEDSK-------------DPKAPIGSQPPSRSRISVSLPVGDRLP 67
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400 1699 DTEKPlfPPAGNSGchnhhnhnsigkQAPTStnanlnnanmskaahgKPPSIGNlehvseNGHYSCkhdrelqRRSSIKR 1778
Cdd:pfam16885   68 DSLSL--GPSDDDG------------GAPNS----------------RQPSVPQ------TGSHTH-------RRSSGVL 104
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400 1779 TryyetYIRSESGDEQFPTICREDpeiHGYfrdprclgeqeyfsseeccEDDSSPTWsRQNYNYYNRYPGSSMDFERPRG 1858
Cdd:pfam16885  105 M-----FTIPEEGSSQPKGTKGQD---KQD-------------------EEEEVPDQ-LSYLDEQAGTPSRPVLLPPHRP 156
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400 1859 YHHPQGFLEDDDS---PTgydsrrsprrrllpptpPSHRRSSFNFECLRRQSSQDDvLPSPALPHRAalplhlmqqqima 1935
Cdd:pfam16885  157 QHYPLREPVDRRRllpPT-----------------PAGRKPSFNIQCLRRQGSCED-LPIPGTYHRG------------- 205
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400 1936 vagldsskaQKYSPSHSTRSWATPPatppyRDWSPCYTPLIQVDRSESMDQVNGSLPSlhrsswytdepdiSYRTFTpaS 2015
Cdd:pfam16885  206 ---------RNSGPSRAQGSWATPP-----QRGRLLYAPLLLVEEGAAGEGYLGKSPG-------------PLRTFT--C 256
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400 2016 LTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNgsvcprangdmg 2095
Cdd:pfam16885  257 LRVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFAQDPKFVALAKQEIADACHLTLDEMDSAASDLLA------------ 324
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|.
gi 1039745400 2096 pishrqdyelQDFGPGYSDEEPD-PGREEEDLADEMICITT 2135
Cdd:pfam16885  325 ----------QGTSSLYSDEESIlSSFDEEDLGDEMACVHA 355
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1224-1452 3.99e-56

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 195.56  E-value: 3.99e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400 1224 SSPFEYMMFVLIMLNTLCLAMQHYEQSKM-FNDAMDILNMVFTGVFTVEMVLKVIAFKPK-------------------- 1282
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKkryfrspwnildfvvvlpsl 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400 1283 ----NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNN 1358
Cdd:pfam00520   81 islvLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWEN 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400 1359 QINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKlcdpdsdynpgeeytcGSNFAIVYFISFYMLCAFLIINLFVA 1438
Cdd:pfam00520  161 PDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK----------------GEFWAYIYFVSFIILGGFLLLNLFIA 224
                          250
                   ....*....|....
gi 1039745400 1439 VIMDNFDYLTRDWS 1452
Cdd:pfam00520  225 VIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
905-1182 6.76e-54

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 189.02  E-value: 6.76e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400  905 HHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHkgaFCRNYFNLLDMLVVG 984
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400  985 VSLVSFGIQS-SAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYR 1063
Cdd:pfam00520   78 PSLISLVLSSvGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400 1064 CTDEaksnpeecrglfilykdgdvdspvvreriwQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENVGPVY- 1142
Cdd:pfam00520  158 WENP------------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAYIYf 207
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 1039745400 1143 -------NYrveisiffiiyiiivafFMMNIFVGFVIVTFQEQGEKE 1182
Cdd:pfam00520  208 vsfiilgGF-----------------LLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
545-780 1.29e-51

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 182.47  E-value: 1.29e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400  545 FYWLVIVLVFLNTLTISSEHYNQPDW-LTQIQDIANKVLLALFTCEMLVKMYSLGL-QAYFVSLFNRFDCFVVCGGITEt 622
Cdd:pfam00520    4 FELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSLIS- 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400  623 iLVELELMSPLGVSVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF-NFDET 701
Cdd:pfam00520   83 -LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLkTWENP 161
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039745400  702 QTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGgpsssGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAES 780
Cdd:pfam00520  162 DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTE 235
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1524-1598 3.53e-37

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


:

Pssm-ID: 462591  Cd Length: 77  Bit Score: 135.03  E-value: 3.53e-37
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039745400 1524 NATLFALVRTALKIKTE--GNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKK 1598
Cdd:pfam08763    1 TATLFALIRTSLKIKLApaGEMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1461-1514 1.39e-30

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


:

Pssm-ID: 465306  Cd Length: 54  Bit Score: 115.44  E-value: 1.39e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039745400 1461 EFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMP 1514
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
125-417 2.45e-70

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 236.39  E-value: 2.45e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400  125 WKPFDIFILLAIFANCVALAIYIPFPEDDSnsTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHpnaYVRNGWNLLDFVI 204
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP--LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400  205 VIVGLFSVILeqltketeggnhsSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 284
Cdd:pfam00520   76 VLPSLISLVL-------------SSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFI 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400  285 YAIIGLELFIGKMHKtcffadsdivaeedpapcafsgngrqctangtecrsgWVGPNGGITNFDNFAFAMLTVFQCITME 364
Cdd:pfam00520  143 FAIIGYQLFGGKLKT-------------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTTE 185
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1039745400  365 GWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAK 417
Cdd:pfam00520  186 GWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
CAC1F_C pfam16885
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1619-2135 4.26e-57

Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.


Pssm-ID: 465298 [Multi-domain]  Cd Length: 355  Bit Score: 202.54  E-value: 4.26e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400 1619 AGLRTLHDIGPEIRRAISCDLQDDEPEDSKPEEEDVFKRNgallgnhvnhvnsDRRDSLQQTNTTHRPLHVQRPSMPPAS 1698
Cdd:pfam16885    1 AGLRSLQDLGPEIRQALTCDTEEEEEEEEGQEGEEEEDSK-------------DPKAPIGSQPPSRSRISVSLPVGDRLP 67
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400 1699 DTEKPlfPPAGNSGchnhhnhnsigkQAPTStnanlnnanmskaahgKPPSIGNlehvseNGHYSCkhdrelqRRSSIKR 1778
Cdd:pfam16885   68 DSLSL--GPSDDDG------------GAPNS----------------RQPSVPQ------TGSHTH-------RRSSGVL 104
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400 1779 TryyetYIRSESGDEQFPTICREDpeiHGYfrdprclgeqeyfsseeccEDDSSPTWsRQNYNYYNRYPGSSMDFERPRG 1858
Cdd:pfam16885  105 M-----FTIPEEGSSQPKGTKGQD---KQD-------------------EEEEVPDQ-LSYLDEQAGTPSRPVLLPPHRP 156
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400 1859 YHHPQGFLEDDDS---PTgydsrrsprrrllpptpPSHRRSSFNFECLRRQSSQDDvLPSPALPHRAalplhlmqqqima 1935
Cdd:pfam16885  157 QHYPLREPVDRRRllpPT-----------------PAGRKPSFNIQCLRRQGSCED-LPIPGTYHRG------------- 205
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400 1936 vagldsskaQKYSPSHSTRSWATPPatppyRDWSPCYTPLIQVDRSESMDQVNGSLPSlhrsswytdepdiSYRTFTpaS 2015
Cdd:pfam16885  206 ---------RNSGPSRAQGSWATPP-----QRGRLLYAPLLLVEEGAAGEGYLGKSPG-------------PLRTFT--C 256
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400 2016 LTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNgsvcprangdmg 2095
Cdd:pfam16885  257 LRVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFAQDPKFVALAKQEIADACHLTLDEMDSAASDLLA------------ 324
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|.
gi 1039745400 2096 pishrqdyelQDFGPGYSDEEPD-PGREEEDLADEMICITT 2135
Cdd:pfam16885  325 ----------QGTSSLYSDEESIlSSFDEEDLGDEMACVHA 355
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1224-1452 3.99e-56

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 195.56  E-value: 3.99e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400 1224 SSPFEYMMFVLIMLNTLCLAMQHYEQSKM-FNDAMDILNMVFTGVFTVEMVLKVIAFKPK-------------------- 1282
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKkryfrspwnildfvvvlpsl 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400 1283 ----NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNN 1358
Cdd:pfam00520   81 islvLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWEN 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400 1359 QINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKlcdpdsdynpgeeytcGSNFAIVYFISFYMLCAFLIINLFVA 1438
Cdd:pfam00520  161 PDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK----------------GEFWAYIYFVSFIILGGFLLLNLFIA 224
                          250
                   ....*....|....
gi 1039745400 1439 VIMDNFDYLTRDWS 1452
Cdd:pfam00520  225 VIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
905-1182 6.76e-54

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 189.02  E-value: 6.76e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400  905 HHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHkgaFCRNYFNLLDMLVVG 984
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400  985 VSLVSFGIQS-SAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYR 1063
Cdd:pfam00520   78 PSLISLVLSSvGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400 1064 CTDEaksnpeecrglfilykdgdvdspvvreriwQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENVGPVY- 1142
Cdd:pfam00520  158 WENP------------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAYIYf 207
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 1039745400 1143 -------NYrveisiffiiyiiivafFMMNIFVGFVIVTFQEQGEKE 1182
Cdd:pfam00520  208 vsfiilgGF-----------------LLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
545-780 1.29e-51

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 182.47  E-value: 1.29e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400  545 FYWLVIVLVFLNTLTISSEHYNQPDW-LTQIQDIANKVLLALFTCEMLVKMYSLGL-QAYFVSLFNRFDCFVVCGGITEt 622
Cdd:pfam00520    4 FELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSLIS- 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400  623 iLVELELMSPLGVSVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF-NFDET 701
Cdd:pfam00520   83 -LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLkTWENP 161
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039745400  702 QTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGgpsssGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAES 780
Cdd:pfam00520  162 DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTE 235
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1524-1598 3.53e-37

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 462591  Cd Length: 77  Bit Score: 135.03  E-value: 3.53e-37
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039745400 1524 NATLFALVRTALKIKTE--GNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKK 1598
Cdd:pfam08763    1 TATLFALIRTSLKIKLApaGEMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1461-1514 1.39e-30

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 115.44  E-value: 1.39e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039745400 1461 EFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMP 1514
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
Ca_chan_IQ smart01062
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1576-1606 1.61e-13

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 198130  Cd Length: 31  Bit Score: 66.09  E-value: 1.61e-13
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1039745400  1576 DEVTVGKFYATFLIQDYFRKFKKRKEQGLVG 1606
Cdd:smart01062    1 DELTVGKIYAAMLIQDYFRQFKSRKEQELLG 31
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
125-417 2.45e-70

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 236.39  E-value: 2.45e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400  125 WKPFDIFILLAIFANCVALAIYIPFPEDDSnsTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHpnaYVRNGWNLLDFVI 204
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP--LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400  205 VIVGLFSVILeqltketeggnhsSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 284
Cdd:pfam00520   76 VLPSLISLVL-------------SSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFI 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400  285 YAIIGLELFIGKMHKtcffadsdivaeedpapcafsgngrqctangtecrsgWVGPNGGITNFDNFAFAMLTVFQCITME 364
Cdd:pfam00520  143 FAIIGYQLFGGKLKT-------------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTTE 185
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1039745400  365 GWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAK 417
Cdd:pfam00520  186 GWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
CAC1F_C pfam16885
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1619-2135 4.26e-57

Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.


Pssm-ID: 465298 [Multi-domain]  Cd Length: 355  Bit Score: 202.54  E-value: 4.26e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400 1619 AGLRTLHDIGPEIRRAISCDLQDDEPEDSKPEEEDVFKRNgallgnhvnhvnsDRRDSLQQTNTTHRPLHVQRPSMPPAS 1698
Cdd:pfam16885    1 AGLRSLQDLGPEIRQALTCDTEEEEEEEEGQEGEEEEDSK-------------DPKAPIGSQPPSRSRISVSLPVGDRLP 67
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400 1699 DTEKPlfPPAGNSGchnhhnhnsigkQAPTStnanlnnanmskaahgKPPSIGNlehvseNGHYSCkhdrelqRRSSIKR 1778
Cdd:pfam16885   68 DSLSL--GPSDDDG------------GAPNS----------------RQPSVPQ------TGSHTH-------RRSSGVL 104
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400 1779 TryyetYIRSESGDEQFPTICREDpeiHGYfrdprclgeqeyfsseeccEDDSSPTWsRQNYNYYNRYPGSSMDFERPRG 1858
Cdd:pfam16885  105 M-----FTIPEEGSSQPKGTKGQD---KQD-------------------EEEEVPDQ-LSYLDEQAGTPSRPVLLPPHRP 156
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400 1859 YHHPQGFLEDDDS---PTgydsrrsprrrllpptpPSHRRSSFNFECLRRQSSQDDvLPSPALPHRAalplhlmqqqima 1935
Cdd:pfam16885  157 QHYPLREPVDRRRllpPT-----------------PAGRKPSFNIQCLRRQGSCED-LPIPGTYHRG------------- 205
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400 1936 vagldsskaQKYSPSHSTRSWATPPatppyRDWSPCYTPLIQVDRSESMDQVNGSLPSlhrsswytdepdiSYRTFTpaS 2015
Cdd:pfam16885  206 ---------RNSGPSRAQGSWATPP-----QRGRLLYAPLLLVEEGAAGEGYLGKSPG-------------PLRTFT--C 256
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400 2016 LTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNgsvcprangdmg 2095
Cdd:pfam16885  257 LRVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFAQDPKFVALAKQEIADACHLTLDEMDSAASDLLA------------ 324
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|.
gi 1039745400 2096 pishrqdyelQDFGPGYSDEEPD-PGREEEDLADEMICITT 2135
Cdd:pfam16885  325 ----------QGTSSLYSDEESIlSSFDEEDLGDEMACVHA 355
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1224-1452 3.99e-56

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 195.56  E-value: 3.99e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400 1224 SSPFEYMMFVLIMLNTLCLAMQHYEQSKM-FNDAMDILNMVFTGVFTVEMVLKVIAFKPK-------------------- 1282
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKkryfrspwnildfvvvlpsl 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400 1283 ----NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNN 1358
Cdd:pfam00520   81 islvLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWEN 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400 1359 QINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKlcdpdsdynpgeeytcGSNFAIVYFISFYMLCAFLIINLFVA 1438
Cdd:pfam00520  161 PDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK----------------GEFWAYIYFVSFIILGGFLLLNLFIA 224
                          250
                   ....*....|....
gi 1039745400 1439 VIMDNFDYLTRDWS 1452
Cdd:pfam00520  225 VIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
905-1182 6.76e-54

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 189.02  E-value: 6.76e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400  905 HHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHkgaFCRNYFNLLDMLVVG 984
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400  985 VSLVSFGIQS-SAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYR 1063
Cdd:pfam00520   78 PSLISLVLSSvGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400 1064 CTDEaksnpeecrglfilykdgdvdspvvreriwQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENVGPVY- 1142
Cdd:pfam00520  158 WENP------------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAYIYf 207
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 1039745400 1143 -------NYrveisiffiiyiiivafFMMNIFVGFVIVTFQEQGEKE 1182
Cdd:pfam00520  208 vsfiilgGF-----------------LLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
545-780 1.29e-51

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 182.47  E-value: 1.29e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400  545 FYWLVIVLVFLNTLTISSEHYNQPDW-LTQIQDIANKVLLALFTCEMLVKMYSLGL-QAYFVSLFNRFDCFVVCGGITEt 622
Cdd:pfam00520    4 FELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSLIS- 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400  623 iLVELELMSPLGVSVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF-NFDET 701
Cdd:pfam00520   83 -LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLkTWENP 161
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039745400  702 QTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGgpsssGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAES 780
Cdd:pfam00520  162 DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTE 235
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1524-1598 3.53e-37

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 462591  Cd Length: 77  Bit Score: 135.03  E-value: 3.53e-37
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039745400 1524 NATLFALVRTALKIKTE--GNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKK 1598
Cdd:pfam08763    1 TATLFALIRTSLKIKLApaGEMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1461-1514 1.39e-30

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 115.44  E-value: 1.39e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039745400 1461 EFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMP 1514
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
Ca_chan_IQ smart01062
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1576-1606 1.61e-13

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 198130  Cd Length: 31  Bit Score: 66.09  E-value: 1.61e-13
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1039745400  1576 DEVTVGKFYATFLIQDYFRKFKKRKEQGLVG 1606
Cdd:smart01062    1 DELTVGKIYAAMLIQDYFRQFKSRKEQELLG 31
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
1290-1445 1.96e-04

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 44.96  E-value: 1.96e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400 1290 ISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFqalpyvALLIAMLFFIYAVIGMQMFGKVAmrdnnqinrnNNFQTF 1369
Cdd:pfam08016  104 VFLTWLKLFKVLRFNKTMSLFTKTLSRAWKDLAGF------ALMFVIFFFAYAQFGYLLFGTQA----------PNFSNF 167
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039745400 1370 PQAVLLLFRcatgeawqeimlaclpgkLCDPDSDYNpgEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFD 1445
Cdd:pfam08016  168 VKSILTLFR------------------TILGDFGYN--EIFSGNRVLGPLLFLTFVFLVIFILLNLFLAIINDSYV 223
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
168-293 2.95e-03

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 41.49  E-value: 2.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039745400  168 FLIIFTVETFLKIiayglLLHPNAYVRNGWNLLDFVIVIVGLFSVIL--------EQLTKETEggnHSSGKSGGFD---- 235
Cdd:pfam08016   20 FFLYFVVEEILKI-----RKHRPSYLRSVWNLLDLAIVILSVVLIVLniyrdflaDRLIKSVE---ASPVTFIDFDrvaq 91
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039745400  236 -------VKALRAFRV-LRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELF 293
Cdd:pfam08016   92 ldnlyriILAFLVFLTwLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLF 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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