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Conserved domains on  [gi|1039744362|ref|XP_017171129|]
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ankyrin repeat domain-containing protein 55 isoform X6 [Mus musculus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11430360)

ankyrin repeat (ANK) domain-containing protein is involved in mediating protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  33435370|17176038

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
57-266 1.84e-38

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 137.78  E-value: 1.84e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  57 DSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAE 136
Cdd:COG0666    84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAAN 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 137 PDVRLLIVLLQQSSlsEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSH 216
Cdd:COG0666   164 GNLEIVKLLLEAGA--DVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEA 241

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1039744362 217 RqgpSIINYDDESGKTCVHIAAASGFGDIINDLAKVPECNLQALDVDDRT 266
Cdd:COG0666   242 G---ADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
Ank_2 pfam12796
Ankyrin repeats (3 copies);
235-316 1.08e-13

Ankyrin repeats (3 copies);


:

Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 65.91  E-value: 1.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 235 HIAAASGFGDIINDLAKvPECNLQALDVDDRTPLHWAAASGKAECVQSLLDlGMDSNLRDiNESTPLAYALYCGHTACVR 314
Cdd:pfam12796   2 HLAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78


                  ..
gi 1039744362 315 LL 316
Cdd:pfam12796  79 LL 80
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
57-266 1.84e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 137.78  E-value: 1.84e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  57 DSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAE 136
Cdd:COG0666    84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAAN 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 137 PDVRLLIVLLQQSSlsEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSH 216
Cdd:COG0666   164 GNLEIVKLLLEAGA--DVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEA 241

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1039744362 217 RqgpSIINYDDESGKTCVHIAAASGFGDIINDLAKVPECNLQALDVDDRT 266
Cdd:COG0666   242 G---ADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
PHA03095 PHA03095
ankyrin-like protein; Provisional
 20-314 2.36e-23

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 99.71  E-value: 2.36e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  20 DSSEEVDLAMVYQAASNGDVNSLTSVIREDPSIlECCDSEGCTPL---MHAVSGRQVDTVKLLLKMGANINTQDAYGRTS 96
Cdd:PHA03095    8 DIIMEAALYDYLLNASNVTVEEVRRLLAAGADV-NFRGEYGKTPLhlyLHYSSEKVKDIVRLLLEAGADVNAPERCGFTP 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  97 LCLATYLGWLEGCVSLL-RNGAKHNIPDKNGRLPLHA-----ATAEPDVRLLIVLLqqsslSEINHQDTEGMTPLH-WAA 169
Cdd:PHA03095   87 LHLYLYNATTLDVIKLLiKAGADVNAKDKVGRTPLHVylsgfNINPKVIRLLLRKG-----ADVNALDLYGMTPLAvLLK 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 170 FHNRPQHT-QMLLKKGADPTLVDKDFKTALHWAVQS---GNRILCSIIlSHRQGPSIINyddESGKTCVHIAAASGF--- 242
Cdd:PHA03095  162 SRNANVELlRLLIDAGADVYAVDDRFRSLLHHHLQSfkpRARIVRELI-RAGCDPAATD---MLGNTPLHSMATGSSckr 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039744362 243 GDIINDLAKVPECNlqALDVDDRTPLHWAAASGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVR 314
Cdd:PHA03095  238 SLVLPLLIAGISIN--ARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVR 307
Ank_2 pfam12796
Ankyrin repeats (3 copies);
198-294 6.73e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.29  E-value: 6.73e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 198 LHWAVQSGNRILCSIILSHRQGPsiiNYDDESGKTCVHIAAASGFGDIINDLAKVPECNLQaldVDDRTPLHWAAASGKA 277
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADA---NLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK---DNGRTALHYAARSGHL 74

                          90
                  ....*....|....*..
gi 1039744362 278 ECVQSLLDLGMDSNLRD 294
Cdd:pfam12796  75 EIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
235-316 1.08e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 65.91  E-value: 1.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 235 HIAAASGFGDIINDLAKvPECNLQALDVDDRTPLHWAAASGKAECVQSLLDlGMDSNLRDiNESTPLAYALYCGHTACVR 314
Cdd:pfam12796   2 HLAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78


                  ..
gi 1039744362 315 LL 316
Cdd:pfam12796  79 LL 80
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 226-316 3.07e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 48.71  E-value: 3.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 226 DDESGKTCVHIAAASGFGDIINDLAKVpecNLQAlDVDD---RTPLHWAAASGKAECVQSLLDLGMDSNLRDINESTPLA 302
Cdd:PLN03192  521 DDPNMASNLLTVASTGNAALLEELLKA---KLDP-DIGDskgRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALW 596

                          90
                  ....*....|....
gi 1039744362 303 YALYCGHTACVRLL 316
Cdd:PLN03192  597 NAISAKHHKIFRIL 610
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 59-87 4.03e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.88  E-value: 4.03e-05
                           10        20
                   ....*....|....*....|....*....
gi 1039744362   59 EGCTPLMHAVSGRQVDTVKLLLKMGANIN 87
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 263-292 8.63e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.03  E-value: 8.63e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1039744362  263 DDRTPLHWAAASGKAECVQSLLDLGMDSNL 292
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 33-183 2.96e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 39.23  E-value: 2.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  33 AASNGDVNSLTSVIREDPS-ILECCDSE---GCTPLMHAVSGRQVDTVKLLLKMGANINTQDA--------------YGR 94
Cdd:cd22192    58 AALYDNLEAAVVLMEAAPElVNEPMTSDlyqGETALHIAVVNQNLNLVRELIARGADVVSPRAtgtffrpgpknliyYGE 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  95 TSLCLATYLGwLEGCVSLL-RNGAKHNIPDKNGRLPLHAATAEPDVRL------LIV----LLQQSSLSEI-NHQdteGM 162
Cdd:cd22192   138 HPLSFAACVG-NEEIVRLLiEHGADIRAQDSLGNTVLHILVLQPNKTFacqmydLILsydkEDDLQPLDLVpNNQ---GL 213

                         170       180
                  ....*....|....*....|.
gi 1039744362 163 TPLHWAAFHNRPQHTQMLLKK 183
Cdd:cd22192   214 TPFKLAAKEGNIVMFQHLVQK 234
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
57-266 1.84e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 137.78  E-value: 1.84e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  57 DSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAE 136
Cdd:COG0666    84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAAN 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 137 PDVRLLIVLLQQSSlsEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSH 216
Cdd:COG0666   164 GNLEIVKLLLEAGA--DVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEA 241

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1039744362 217 RqgpSIINYDDESGKTCVHIAAASGFGDIINDLAKVPECNLQALDVDDRT 266
Cdd:COG0666   242 G---ADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
57-301 1.04e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 130.84  E-value: 1.04e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  57 DSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAE 136
Cdd:COG0666    51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 137 PDVRLLIVLLQQSslSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSH 216
Cdd:COG0666   131 GNLEIVKLLLEAG--ADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEA 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 217 RqgpSIINYDDESGKTCVHIAAASGFGDIINDLAKVPEcNLQALDVDDRTPLHWAAASGKAECVQSLLDLGMDSNLRDIN 296
Cdd:COG0666   209 G---ADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGA-DLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLD 284


                  ....*
gi 1039744362 297 ESTPL 301
Cdd:COG0666   285 LLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
62-322 1.61e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 122.37  E-value: 1.61e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  62 TPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDVRL 141
Cdd:COG0666    23 LLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEI 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 142 LIVLLQQSSlsEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHrqgps 221
Cdd:COG0666   103 VKLLLEAGA--DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEA----- 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 222 iinyddesgktcvhiaaasgfGDIINdlakvpecnlqALDVDDRTPLHWAAASGKAECVQSLLDLGMDSNLRDINESTPL 301
Cdd:COG0666   176 ---------------------GADVN-----------ARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTAL 223

                         250       260
                  ....*....|....*....|.
gi 1039744362 302 AYALYCGHTACVRLLSREGRA 322
Cdd:COG0666   224 DLAAENGNLEIVKLLLEAGAD 244
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
76-316 1.70e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 100.41  E-value: 1.70e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  76 VKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAepDVRLLIVLLQQSSLSEIN 155
Cdd:COG0666     4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAAL--AGDLLVALLLLAAGADIN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 156 HQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHrqgpsiinyddesgktcvh 235
Cdd:COG0666    82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEA------------------- 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 236 iaaasgfgdiindlakvpECNLQALDVDDRTPLHWAAASGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRL 315
Cdd:COG0666   143 ------------------GADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKL 204


                  .
gi 1039744362 316 L 316
Cdd:COG0666   205 L 205
PHA03095 PHA03095
ankyrin-like protein; Provisional
 20-314 2.36e-23

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 99.71  E-value: 2.36e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  20 DSSEEVDLAMVYQAASNGDVNSLTSVIREDPSIlECCDSEGCTPL---MHAVSGRQVDTVKLLLKMGANINTQDAYGRTS 96
Cdd:PHA03095    8 DIIMEAALYDYLLNASNVTVEEVRRLLAAGADV-NFRGEYGKTPLhlyLHYSSEKVKDIVRLLLEAGADVNAPERCGFTP 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  97 LCLATYLGWLEGCVSLL-RNGAKHNIPDKNGRLPLHA-----ATAEPDVRLLIVLLqqsslSEINHQDTEGMTPLH-WAA 169
Cdd:PHA03095   87 LHLYLYNATTLDVIKLLiKAGADVNAKDKVGRTPLHVylsgfNINPKVIRLLLRKG-----ADVNALDLYGMTPLAvLLK 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 170 FHNRPQHT-QMLLKKGADPTLVDKDFKTALHWAVQS---GNRILCSIIlSHRQGPSIINyddESGKTCVHIAAASGF--- 242
Cdd:PHA03095  162 SRNANVELlRLLIDAGADVYAVDDRFRSLLHHHLQSfkpRARIVRELI-RAGCDPAATD---MLGNTPLHSMATGSSckr 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039744362 243 GDIINDLAKVPECNlqALDVDDRTPLHWAAASGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVR 314
Cdd:PHA03095  238 SLVLPLLIAGISIN--ARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVR 307
PHA03095 PHA03095
ankyrin-like protein; Provisional
 73-316 5.01e-22

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 95.86  E-value: 5.01e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  73 VDTVKLLLKMGANINTQDAYGRTSLC--LATYLGWLEGCVS-LLRNGAKHNIPDKNGRLPLHA----ATAEPDVRLLIvl 145
Cdd:PHA03095   27 VEEVRRLLAAGADVNFRGEYGKTPLHlyLHYSSEKVKDIVRlLLEAGADVNAPERCGFTPLHLylynATTLDVIKLLI-- 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 146 lqqSSLSEINHQDTEGMTPLH--WAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGN------RILCsiilshR 217
Cdd:PHA03095  105 ---KAGADVNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNanvellRLLI------D 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 218 QGPSIINYDDEsGKTCVHIAAAS--GFGDIINDLAkVPECNLQALDVDDRTPLHWAAA--SGKAECVQSLLDLGMDSNLR 293
Cdd:PHA03095  176 AGADVYAVDDR-FRSLLHHHLQSfkPRARIVRELI-RAGCDPAATDMLGNTPLHSMATgsSCKRSLVLPLLIAGISINAR 253

                         250       260
                  ....*....|....*....|....
gi 1039744362 294 DINESTPLAYA-LYCGHTACVRLL 316
Cdd:PHA03095  254 NRYGQTPLHYAaVFNNPRACRRLI 277
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 67-222 3.10e-17

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 81.64  E-value: 3.10e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  67 AVSGRQVDTVKLLLKMGANINTQDAYGRTSL--CLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLIV 144
Cdd:PHA03100   80 YNLTDVKEIVKLLLEYGANVNAPDNNGITPLlyAISKKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLKIL 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 145 --LLQQ--------------SSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRI 208
Cdd:PHA03100  160 klLIDKgvdinaknrvnyllSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKE 239

                         170
                  ....*....|....
gi 1039744362 209 LCSIILSHrqGPSI 222
Cdd:PHA03100  240 IFKLLLNN--GPSI 251
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 61-320 3.53e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 75.47  E-value: 3.53e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  61 CTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLclatylgwlegcvSLLRNgAKHNIPDkngrlplhaataepDVR 140
Cdd:PHA03100   36 VLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPL-------------HYLSN-IKYNLTD--------------VKE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 141 LLIVLLQQSSLseINHQDTEGMTPLHWAAfHNRPQHTQM---LLKKGADPTLVDKDFKTALHWAVQSGNRIL--CSIILS 215
Cdd:PHA03100   88 IVKLLLEYGAN--VNAPDNNGITPLLYAI-SKKSNSYSIveyLLDNGANVNIKNSDGENLLHLYLESNKIDLkiLKLLID 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 216 HRqgpsiinyddesgktcVHIAAAsgfgDIINDLAKVpECNLQALDVDDRTPLHWAAASGKAECVQSLLDLGMDSNLRDI 295
Cdd:PHA03100  165 KG----------------VDINAK----NRVNYLLSY-GVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNK 223

                         250       260
                  ....*....|....*....|....*
gi 1039744362 296 NESTPLAYALYCGHTACVRLLSREG 320
Cdd:PHA03100  224 YGDTPLHIAILNNNKEIFKLLLNNG 248
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 25-304 1.40e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 74.33  E-value: 1.40e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  25 VDLAMVYQAasngDVNSLTsviREDPSILECcdsegctplmhAVSGRQVDTVKLLLKMGANINTQDaygrTSLCLATYLG 104
Cdd:PHA02876  194 VNLLLSYGA----DVNIIA---LDDLSVLEC-----------AVDSKNIDTIKAIIDNRSNINKND----LSLLKAIRNE 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 105 WLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDV-RLLIVLLQQSSlsEINHQDTEGMTPLHWAAFHN-RPQHTQMLLK 182
Cdd:PHA02876  252 DLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLsRLVPKLLERGA--DVNAKNIKGETPLYLMAKNGyDTENIRTLIM 329

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 183 KGADPTLVDKDFKTALHWAvQSGNRILCSIILSHRQGPSIiNYDDESGKTCVHIAAASGFGDIINDLAKVpECNLQALDV 262
Cdd:PHA02876  330 LGADVNAADRLYITPLHQA-STLDRNKDIVITLLELGANV-NARDYCDKTPIHYAAVRNNVVIINTLLDY-GADIEALSQ 406

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1039744362 263 DDRTPLHWA-AASGKAECVQSLLDLGMDSNLRDINESTPLAYA 304
Cdd:PHA02876  407 KIGTALHFAlCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYA 449
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 51-237 6.38e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 71.92  E-value: 6.38e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  51 SILECC------DSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDK 124
Cdd:PHA02874  109 TILDCGidvnikDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDN 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 125 NGRLPLHAATAEPDVRLLIVLLQQSslSEINHQDTEGMTPLHWAAFHNRPqhTQMLLKKGADPTLVDKDFKTALHWAVQS 204
Cdd:PHA02874  189 NGESPLHNAAEYGDYACIKLLIDHG--NHIMNKCKNGFTPLHNAIIHNRS--AIELLINNASINDQDIDGSTPLHHAINP 264

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1039744362 205 GNRI-LCSIILSHRQGPSIinyDDESGKTCVHIA 237
Cdd:PHA02874  265 PCDIdIIDILLYHKADISI---KDNKGENPIDTA 295
Ank_2 pfam12796
Ankyrin repeats (3 copies);
198-294 6.73e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.29  E-value: 6.73e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 198 LHWAVQSGNRILCSIILSHRQGPsiiNYDDESGKTCVHIAAASGFGDIINDLAKVPECNLQaldVDDRTPLHWAAASGKA 277
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADA---NLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK---DNGRTALHYAARSGHL 74

                          90
                  ....*....|....*..
gi 1039744362 278 ECVQSLLDLGMDSNLRD 294
Cdd:pfam12796  75 EIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
235-316 1.08e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 65.91  E-value: 1.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 235 HIAAASGFGDIINDLAKvPECNLQALDVDDRTPLHWAAASGKAECVQSLLDlGMDSNLRDiNESTPLAYALYCGHTACVR 314
Cdd:pfam12796   2 HLAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78


                  ..
gi 1039744362 315 LL 316
Cdd:pfam12796  79 LL 80
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 26-320 1.09e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 71.63  E-value: 1.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  26 DLAMVyQAASNGDVNslTSVIREDPSI-LECCDSEGCTPLMHAVSGRQVDT-VKLLLKMGANINTQDAYGRTSLCLATYL 103
Cdd:PHA02876  241 DLSLL-KAIRNEDLE--TSLLLYDAGFsVNSIDDCKNTPLHHASQAPSLSRlVPKLLERGADVNAKNIKGETPLYLMAKN 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 104 GW-LEGCVSLLRNGAKHNIPDKNGRLPLH-AATAEPDVRLLIVLLQQSSlsEINHQDTEGMTPLHWAAFHNRPQHTQMLL 181
Cdd:PHA02876  318 GYdTENIRTLIMLGADVNAADRLYITPLHqASTLDRNKDIVITLLELGA--NVNARDYCDKTPIHYAAVRNNVVIINTLL 395

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 182 KKGADPTLVDKDFKTALHWAVQSGNRILcsiilshrqgpsiinyddeSGKTCVHIAAasgfgdiindlakvpecNLQALD 261
Cdd:PHA02876  396 DYGADIEALSQKIGTALHFALCGTNPYM-------------------SVKTLIDRGA-----------------NVNSKN 439

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 262 VDDRTPLHWAAASG-KAECVQSLLDLGMDSNLRDINESTPLAYALycGHTACVRLLSREG 320
Cdd:PHA02876  440 KDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIAL--EYHGIVNILLHYG 497
Ank_2 pfam12796
Ankyrin repeats (3 copies);
64-191 1.36e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 65.52  E-value: 1.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  64 LMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEgCVSLLrngAKHNIPDKngrlplhaataepdvrlli 143
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLE-IVKLL---LEHADVNL------------------- 57

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1039744362 144 vllqqsslseinhqDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVD 191
Cdd:pfam12796  58 --------------KDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 64-292 3.37e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 69.63  E-value: 3.37e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  64 LMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLI 143
Cdd:PHA02875    6 LCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 144 VLLQQSS-LSEINHQDteGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRqgpSI 222
Cdd:PHA02875   86 ELLDLGKfADDVFYKD--GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHK---AC 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 223 INYDDESGKTCVHIAAASG----------FGDIINDLAKVPecnlqaldvdDRTPLHWAAASGKAECVQSLLDLGMDSNL 292
Cdd:PHA02875  161 LDIEDCCGCTPLIIAMAKGdiaickmlldSGANIDYFGKNG----------CVAALCYAIENNKIDIVRLFIKRGADCNI 230
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 36-305 4.49e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 69.22  E-value: 4.49e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  36 NGDVNSLTSVIREDPSILECCDSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLG-------WLEG 108
Cdd:PHA02874   11 SGDIEAIEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGahdiiklLIDN 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 109 CV----------------SLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLIVLLQQSslSEINHQDTEGMTPLHWAAFHN 172
Cdd:PHA02874   91 GVdtsilpipciekdmikTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYG--ADVNIEDDNGCYPIHIAIKHN 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 173 RPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHrqGPSIINyDDESGKTCVHIAaasgfgdIINDLAKV 252
Cdd:PHA02874  169 FFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDH--GNHIMN-KCKNGFTPLHNA-------IIHNRSAI 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1039744362 253 P----ECNLQALDVDDRTPLHWA-AASGKAECVQSLLDLGMDSNLRDINESTPLAYAL 305
Cdd:PHA02874  239 EllinNASINDQDIDGSTPLHHAiNPPCDIDIIDILLYHKADISIKDNKGENPIDTAF 296
PHA03095 PHA03095
ankyrin-like protein; Provisional
 56-222 1.24e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 68.13  E-value: 1.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  56 CDSEGCTPLMHAVSGRQVD--TVKLLLKMGANINTQDAYGRTSL-CLATYLGWLEGCVS-LLRNGAKHNIPDKNGRLPLH 131
Cdd:PHA03095  148 LDLYGMTPLAVLLKSRNANveLLRLLIDAGADVYAVDDRFRSLLhHHLQSFKPRARIVReLIRAGCDPAATDMLGNTPLH 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 132 -AATAEPDVRLLIVLLQQSSLSeINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILC 210
Cdd:PHA03095  228 sMATGSSCKRSLVLPLLIAGIS-INARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAV 306

                         170
                  ....*....|..
gi 1039744362 211 SIILSHRqgPSI 222
Cdd:PHA03095  307 RAALAKN--PSA 316
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 60-224 1.57e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 64.90  E-value: 1.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  60 GCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAE-PD 138
Cdd:PHA02878  168 GNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYcKD 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 139 VRLLIVLLQQSslSEINHQDT-EGMTPLHwAAFHNrPQHTQMLLKKGADPTLVDKDFKTALHWAVQS------GNRILCS 211
Cdd:PHA02878  248 YDILKLLLEHG--VDVNAKSYiLGLTALH-SSIKS-ERKLKLLLEYGADINSLNSYKLTPLSSAVKQylciniGRILISN 323

                         170
                  ....*....|...
gi 1039744362 212 IILSHRQGPSIIN 224
Cdd:PHA02878  324 ICLLKRIKPDIKN 336
Ank_2 pfam12796
Ankyrin repeats (3 copies);
32-123 2.92e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.97  E-value: 2.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  32 QAASNGDVNSLTSVIREDPSIlECCDSEGCTPLMHAVSGRQVDTVKLLLKmGANINTQDaYGRTSLCLATYLGWLEGCVS 111
Cdd:pfam12796   3 LAAKNGNLELVKLLLENGADA-NLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|..
gi 1039744362 112 LLRNGAKHNIPD 123
Cdd:pfam12796  80 LLEKGADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 30-190 1.63e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 61.55  E-value: 1.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  30 VYQAASNGDVNSLTSVIREDPSILECCDSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGC 109
Cdd:PHA02875   72 LHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGI 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 110 VSLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLIVLLqqSSLSEINHQDTEG-MTPLHWAAFHNRPQHTQMLLKKGADPT 188
Cdd:PHA02875  152 ELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLL--DSGANIDYFGKNGcVAALCYAIENNKIDIVRLFIKRGADCN 229


                  ..
gi 1039744362 189 LV 190
Cdd:PHA02875  230 IM 231
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 61-317 3.37e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 60.66  E-value: 3.37e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  61 CTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSL---CLA--------------------TYLGWLEGC-------- 109
Cdd:PHA02878   38 FIPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLhiiCKEpnklgmkemirsinkcsvfyTLVAIKDAFnnrnveif 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 110 VSLLRNGAKHN--IPDKNgrlpLHAATAEPDVRLLIVLLQQSSLSEINHQDTE-GMTPLHWAAFHNRPQHTQMLLKKGAD 186
Cdd:PHA02878  118 KIILTNRYKNIqtIDLVY----IDKKSKDDIIEAEITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGAN 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 187 PTLVDKDFKTALHWAVQSGNRILCSIILshrQGPSIINYDDESGKTCVHIAAASGFG-DIINDLAKVPEC-NLQAlDVDD 264
Cdd:PHA02878  194 VNIPDKTNNSPLHHAVKHYNKPIVHILL---ENGASTDARDKCGNTPLHISVGYCKDyDILKLLLEHGVDvNAKS-YILG 269

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1039744362 265 RTPLHWAAASGKAecVQSLLDLGMDSNLRDINESTPLAYAL--YCGHTACVRLLS 317
Cdd:PHA02878  270 LTALHSSIKSERK--LKLLLEYGADINSLNSYKLTPLSSAVkqYLCINIGRILIS 322
Ank_2 pfam12796
Ankyrin repeats (3 copies);
268-316 7.61e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.12  E-value: 7.61e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1039744362 268 LHWAAASGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRLL 316
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLL 49
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 94-323 1.87e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 58.46  E-value: 1.87e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  94 RTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLIVLLQQSSLSEINHQDTEgmTPLHWAAFHNR 173
Cdd:PHA02875    3 QVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIE--SELHDAVEEGD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 174 PQHTQMLLKKGadpTLVD----KDFKTALHWAVQSGNRILCSIILSHRQGPSIINYDDesgKTCVHIAAASGFGDIINDL 249
Cdd:PHA02875   81 VKAVEELLDLG---KFADdvfyKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDK---FSPLHLAVMMGDIKGIELL 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039744362 250 AKVPECnlqaLDVDD---RTPLHWAAASGKAECVQSLLDLGMDSNLRDIN-ESTPLAYALYCGHTACVRLLSREGRAC 323
Cdd:PHA02875  155 IDHKAC----LDIEDccgCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNgCVAALCYAIENNKIDIVRLFIKRGADC 228
Ank_4 pfam13637
Ankyrin repeats (many copies);
265-316 4.12e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.89  E-value: 4.12e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1039744362 265 RTPLHWAAASGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRLL 316
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
Ank_2 pfam12796
Ankyrin repeats (3 copies);
130-216 5.72e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 52.43  E-value: 5.72e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 130 LHAATAEPDVRLLIVLLQQSSlsEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKgADPTLVDKDfKTALHWAVQSGNRIL 209
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGA--DANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNG-RTALHYAARSGHLEI 76


                  ....*..
gi 1039744362 210 CSIILSH 216
Cdd:pfam12796  77 VKLLLEK 83
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 14-301 1.38e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 55.84  E-value: 1.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  14 FDQHKGDSS----EEVDLAMVYQAASNGDVNSLTSVIREDPSILECCDSEgCTPLMHAVS-GRQVDTVKLLLKMGANINT 88
Cdd:PHA02876   25 YDLHKHGANqcenESIPFTAIHQALQLRQIDIVEEIIQQNPELIYITDHK-CHSTLHTICiIPNVMDIVISLTLDCDIIL 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  89 QDAYgrTSLCLATY-LGwlEGCVSLLRNGAKHN------IPDKNGRLPLHAATAEPDvRLLIVLLQQSSLSEINHQDTEG 161
Cdd:PHA02876  104 DIKY--ASIILNKHkLD--EACIHILKEAISGNdihydkINESIEYMKLIKERIQQD-ELLIAEMLLEGGADVNAKDIYC 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 162 MTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRqgpSIINYDDESGKTCVH------ 235
Cdd:PHA02876  179 ITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNR---SNINKNDLSLLKAIRnedlet 255

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039744362 236 --IAAASGFgdiindlakvpecNLQALDVDDRTPLHWAA-ASGKAECVQSLLDLGMDSNLRDINESTPL 301
Cdd:PHA02876  256 slLLYDAGF-------------SVNSIDDCKNTPLHHASqAPSLSRLVPKLLERGADVNAKNIKGETPL 311
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 139-218 3.03e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.90  E-value: 3.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 139 VRLLIvllqqSSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRQ 218
Cdd:PTZ00322   98 ARILL-----TGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQ 172
Ank_4 pfam13637
Ankyrin repeats (many copies);
161-206 4.03e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.11  E-value: 4.03e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1039744362 161 GMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGN 206
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGN 46
PHA02946 PHA02946
ankyin-like protein; Provisional
 155-301 1.51e-06

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 49.28  E-value: 1.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 155 NHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRQGPSIINYDDESGktCV 234
Cdd:PHA02946   66 NETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDEVIERINLLVQYGAKINNSVDEEG--CG 143

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039744362 235 HIAAASGFGDIIndLAKVPECNLQALDVD----DRTPLHWAAASGKAECVQSLLDLGMDSNLRDINESTPL 301
Cdd:PHA02946  144 PLLACTDPSERV--FKKIMSIGFEARIVDkfgkNHIHRHLMSDNPKASTISWMMKLGISPSKPDHDGNTPL 212
Ank_5 pfam13857
Ankyrin repeats (many copies);
255-304 1.52e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 44.64  E-value: 1.52e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1039744362 255 CNLQALDVDDRTPLHWAAASGKAECVQSLLDLGMDSNLRDINESTPLAYA 304
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 226-316 3.07e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 48.71  E-value: 3.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 226 DDESGKTCVHIAAASGFGDIINDLAKVpecNLQAlDVDD---RTPLHWAAASGKAECVQSLLDLGMDSNLRDINESTPLA 302
Cdd:PLN03192  521 DDPNMASNLLTVASTGNAALLEELLKA---KLDP-DIGDskgRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALW 596

                          90
                  ....*....|....
gi 1039744362 303 YALYCGHTACVRLL 316
Cdd:PLN03192  597 NAISAKHHKIFRIL 610
Ank_2 pfam12796
Ankyrin repeats (3 copies);
31-90 4.22e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 44.34  E-value: 4.22e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039744362  31 YQAASNGDVNsltsVIREdpsILECCD----SEGCTPLMHAVSGRQVDTVKLLLKMGANINTQD 90
Cdd:pfam12796  35 HLAAKNGHLE----IVKL---LLEHADvnlkDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_5 pfam13857
Ankyrin repeats (many copies);
146-201 6.00e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.10  E-value: 6.00e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039744362 146 LQQSSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWA 201
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02798 PHA02798
ankyrin-like protein; Provisional
 73-213 1.60e-05

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 46.37  E-value: 1.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  73 VDTVKLLLKMGANINTQDAYGRTSLC-----LATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAataepdvrllivLLQ 147
Cdd:PHA02798   51 TDIVKLFINLGANVNGLDNEYSTPLCtilsnIKDYKHMLDIVKILIENGADINKKNSDGETPLYC------------LLS 118

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039744362 148 QSSLseinhqdtegmtplhwaafhNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSII 213
Cdd:PHA02798  119 NGYI--------------------NNLEILLFMIENGADTTLLDKDGFTMLQVYLQSNHHIDIEII 164
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 180-320 2.82e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 45.63  E-value: 2.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 180 LLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRQGpsiINYDDESGKTCVHIAAASGFGDIINDL-----AKVPE 254
Cdd:PLN03192  544 LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACN---VHIRDANGNTALWNAISAKHHKIFRILyhfasISDPH 620

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039744362 255 CnlqALDVddrtpLHWAAASGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRLLSREG 320
Cdd:PLN03192  621 A---AGDL-----LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNG 678
Ank_5 pfam13857
Ankyrin repeats (many copies);
46-100 2.98e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.18  E-value: 2.98e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1039744362  46 IREDPSILECCDSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLA 100
Cdd:pfam13857   2 LEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 18-193 3.19e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 45.63  E-value: 3.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  18 KGDSSEE-VDLAM---VYQAASNGDVNSLTSVIR--EDPSIlecCDSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDA 91
Cdd:PLN03192  513 LGDNGGEhDDPNMasnLLTVASTGNAALLEELLKakLDPDI---GDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDA 589

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  92 YGRTSLCLATYLGWLEgCVSLLRNGAKHNIPDKNGRLpLHAATAEPDVRLLIVLLQQSslSEINHQDTEGMTPLHWAAFH 171
Cdd:PLN03192  590 NGNTALWNAISAKHHK-IFRILYHFASISDPHAAGDL-LCTAAKRNDLTAMKELLKQG--LNVDSEDHQGATALQVAMAE 665

                         170       180
                  ....*....|....*....|..
gi 1039744362 172 NRPQHTQMLLKKGADPTLVDKD 193
Cdd:PLN03192  666 DHVDMVRLLIMNGADVDKANTD 687
Ank_4 pfam13637
Ankyrin repeats (many copies);
126-181 3.20e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.72  E-value: 3.20e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039744362 126 GRLPLHAATAEPDVRLLIVLLQqsSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLL 181
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLE--KGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 261-318 3.52e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.27  E-value: 3.52e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1039744362 261 DVDDRTPLHWAAASGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRLLSR 318
Cdd:PTZ00322  112 DYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 59-87 4.03e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.88  E-value: 4.03e-05
                           10        20
                   ....*....|....*....|....*....
gi 1039744362   59 EGCTPLMHAVSGRQVDTVKLLLKMGANIN 87
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 49-155 5.98e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.50  E-value: 5.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  49 DPSILECCDSEGCTplmHAVSGRQVDtVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRL 128
Cdd:PTZ00322   75 DPVVAHMLTVELCQ---LAASGDAVG-ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKT 150

                          90       100
                  ....*....|....*....|....*..
gi 1039744362 129 PLHAAtAEPDVRLLIVLLQQSSLSEIN 155
Cdd:PTZ00322  151 PLELA-EENGFREVVQLLSRHSQCHFE 176
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 178-259 1.01e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.12  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 178 QMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRQGPSIInydDESGKTCVHIAAASGFGDIINDLAKVPECNL 257
Cdd:PTZ00322   99 RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLL---DKDGKTPLELAEENGFREVVQLLSRHSQCHF 175


                  ..
gi 1039744362 258 QA 259
Cdd:PTZ00322  176 EL 177
PHA02791 PHA02791
ankyrin-like protein; Provisional
 123-206 1.68e-04

ankyrin-like protein; Provisional


Pssm-ID: 165154 [Multi-domain]  Cd Length: 284  Bit Score: 42.72  E-value: 1.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 123 DKNGRLPLHAATAEPDVRLLIVLLQQSSLSEInhqdTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAV 202
Cdd:PHA02791   27 DVHGHSALYYAIADNNVRLVCTLLNAGALKNL----LENEFPLHQAATLEDTKIVKILLFSGMDDSQFDDKGNTALYYAV 102


                  ....
gi 1039744362 203 QSGN 206
Cdd:PHA02791  103 DSGN 106
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 59-90 1.95e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.04  E-value: 1.95e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1039744362  59 EGCTPLMHAV-SGRQVDTVKLLLKMGANINTQD 90
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 160-192 2.05e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.04  E-value: 2.05e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1039744362 160 EGMTPLHWAAFH-NRPQHTQMLLKKGADPTLVDK 192
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 160-187 3.05e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 37.62  E-value: 3.05e-04
                          10        20
                  ....*....|....*....|....*...
gi 1039744362 160 EGMTPLHWAAFHNRPQHTQMLLKKGADP 187
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADI 28
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 248-316 3.27e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.19  E-value: 3.27e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039744362 248 DLAKVPECNLQALDVDDRTPLHWA-------AASGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRLL 316
Cdd:PTZ00322   59 NKDATPDHNLTTEEVIDPVVAHMLtvelcqlAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVL 134
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 160-189 4.88e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 4.88e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1039744362  160 EGMTPLHWAAFHNRPQHTQMLLKKGADPTL 189
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_4 pfam13637
Ankyrin repeats (many copies);
62-113 5.71e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.25  E-value: 5.71e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1039744362  62 TPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEgCVSLL 113
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVE-VLKLL 53
PHA02798 PHA02798
ankyrin-like protein; Provisional
 57-166 7.95e-04

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 40.97  E-value: 7.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  57 DSEGCTPLMHAVSG-----RQVDTVKLLLKMGANINTQDAYGRTSLCLA---TYLGWLEGCVSLLRNGAKHNIPDKNGRL 128
Cdd:PHA02798   68 DNEYSTPLCTILSNikdykHMLDIVKILIENGADINKKNSDGETPLYCLlsnGYINNLEILLFMIENGADTTLLDKDGFT 147

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1039744362 129 PLHA---ATAEPDVRLLIVLLQQSslSEIN-HQDTEGMTPLH 166
Cdd:PHA02798  148 MLQVylqSNHHIDIEIIKLLLEKG--VDINtHNNKEKYDTLH 187
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 263-292 8.63e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.03  E-value: 8.63e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1039744362  263 DDRTPLHWAAASGKAECVQSLLDLGMDSNL 292
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 263-294 8.71e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.11  E-value: 8.71e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1039744362 263 DDRTPLHWAAAS-GKAECVQSLLDLGMDSNLRD 294
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 59-88 1.03e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.08  E-value: 1.03e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1039744362  59 EGCTPLMHAVSGRQVDTVKLLLKMGANINT 88
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
PHA02946 PHA02946
ankyin-like protein; Provisional
 51-258 1.21e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 40.42  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  51 SILECCDSEGCTPLMHA---VSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGR 127
Cdd:PHA02946   27 NMLQAIEPSGNYHILHAycgIKGLDERFVEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHK 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 128 LPLHAATAEPD-VRLLIVLLQQSSLSEINHQDTEGMTPLhWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGN 206
Cdd:PHA02946  107 TPLYYLSGTDDeVIERINLLVQYGAKINNSVDEEGCGPL-LACTDPSERVFKKIMSIGFEARIVDKFGKNHIHRHLMSDN 185

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1039744362 207 RILCSIILSHRQGPSiINYDDESGKTCVHIAAASGFG--DIINDLAKVPECNLQ 258
Cdd:PHA02946  186 PKASTISWMMKLGIS-PSKPDHDGNTPLHIVCSKTVKnvDIINLLLPSTDVNKQ 238
PHA02798 PHA02798
ankyrin-like protein; Provisional
 72-225 1.31e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 40.20  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  72 QVDTVKLLLKMGANINT-QDAYGRTSL-ClatYLGWLEGCVS------LLRNGAKHNIPDKNGRLPLhaataepdVRLLI 143
Cdd:PHA02798  160 DIEIIKLLLEKGVDINThNNKEKYDTLhC---YFKYNIDRIDadilklFVDNGFIINKENKSHKKKF--------MEYLN 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 144 VLLQQS------------SLSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCS 211
Cdd:PHA02798  229 SLLYDNkrfkknildfifSYIDINQVDELGFNPLYYSVSHNNRKIFEYLLQLGGDINIITELGNTCLFTAFENESKFIFN 308

                         170
                  ....*....|....
gi 1039744362 212 IILSHRQGPSIINY 225
Cdd:PHA02798  309 SILNKKPNKNTISY 322
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 33-183 2.96e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 39.23  E-value: 2.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  33 AASNGDVNSLTSVIREDPS-ILECCDSE---GCTPLMHAVSGRQVDTVKLLLKMGANINTQDA--------------YGR 94
Cdd:cd22192    58 AALYDNLEAAVVLMEAAPElVNEPMTSDlyqGETALHIAVVNQNLNLVRELIARGADVVSPRAtgtffrpgpknliyYGE 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  95 TSLCLATYLGwLEGCVSLL-RNGAKHNIPDKNGRLPLHAATAEPDVRL------LIV----LLQQSSLSEI-NHQdteGM 162
Cdd:cd22192   138 HPLSFAACVG-NEEIVRLLiEHGADIRAQDSLGNTVLHILVLQPNKTFacqmydLILsydkEDDLQPLDLVpNNQ---GL 213

                         170       180
                  ....*....|....*....|.
gi 1039744362 163 TPLHWAAFHNRPQHTQMLLKK 183
Cdd:cd22192   214 TPFKLAAKEGNIVMFQHLVQK 234
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 128-206 3.32e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 39.23  E-value: 3.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 128 LPLHAATAEPDVRLLIVLLQQSSlSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKkgADPTLVDK----DF---KTALHW 200
Cdd:cd22192    19 SPLLLAAKENDVQAIKKLLKCPS-CDLFQRGALGETALHVAALYDNLEAAVVLME--AAPELVNEpmtsDLyqgETALHI 95


                  ....*.
gi 1039744362 201 AVQSGN 206
Cdd:cd22192    96 AVVNQN 101
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 154-320 4.08e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 38.79  E-value: 4.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 154 INHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRQGPSIINyddesgktc 233
Cdd:PHA02874   28 INISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSILP--------- 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 234 vhiaaasgFGDIINDLAK-VPECNLQA--LDVDDRTPLHWAAASGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHT 310
Cdd:PHA02874   99 --------IPCIEKDMIKtILDCGIDVniKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFF 170

                         170
                  ....*....|
gi 1039744362 311 ACVRLLSREG 320
Cdd:PHA02874  171 DIIKLLLEKG 180
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 263-291 5.17e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.16  E-value: 5.17e-03
                          10        20
                  ....*....|....*....|....*....
gi 1039744362 263 DDRTPLHWAAASGKAECVQSLLDLGMDSN 291
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 256-305 6.50e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 38.12  E-value: 6.50e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1039744362 256 NLQALDVDDRTPLHWAAASGKAECVQSLLDLGMDSNLRDINESTPLAYAL 305
Cdd:PHA02876  170 DVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAV 219
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 45-223 7.63e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 37.80  E-value: 7.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362  45 VIREDPSILECCDSEGCTP----LMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLclatylgwlegcVSLLRNgakhn 120
Cdd:PHA02989  166 LLSFGVNLFEKTSLYGLTPmniyLRNDIDVISIKVIKYLIKKGVNIETNNNGSESVL------------ESFLDN----- 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 121 ipdkngrlplHAATAEPDVRLLIVLLQQSSlseINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHW 200
Cdd:PHA02989  229 ----------NKILSKKEFKVLNFILKYIK---INKKDKKGFNPLLISAKVDNYEAFNYLLKLGDDIYNVSKDGDTVLTY 295

                         170       180
                  ....*....|....*....|...
gi 1039744362 201 AVQSGNRILCSIILSHRQGPSII 223
Cdd:PHA02989  296 AIKHGNIDMLNRILQLKPGKYLI 318
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 112-301 9.45e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 37.93  E-value: 9.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 112 LLRNGAKHNIPDKNGRLPLHAATAepDVRLLIVLLQQSSLSEINhqDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVD 191
Cdd:PLN03192  513 LGDNGGEHDDPNMASNLLTVASTG--NAALLEELLKAKLDPDIG--DSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRD 588

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744362 192 KDFKTALHWAVQSG-NRILCsiILSHrqgpsiinyddesgktCVHIAAASGFGDII------NDLAKVPECNLQALDVD- 263
Cdd:PLN03192  589 ANGNTALWNAISAKhHKIFR--ILYH----------------FASISDPHAAGDLLctaakrNDLTAMKELLKQGLNVDs 650

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1039744362 264 -DR---TPLHWAAASGKAECVQSLLDLGMD---SNLRDINESTPL 301
Cdd:PLN03192  651 eDHqgaTALQVAMAEDHVDMVRLLIMNGADvdkANTDDDFSPTEL 695
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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