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Conserved domains on  [gi|1039743493|ref|XP_017170963|]
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exocyst complex component 3 isoform X2 [Mus musculus]

Protein Classification

exocyst complex component Sec6 family protein( domain architecture ID 10532741)

exocyst complex component Sec6 family protein similar to human exocyst complex component 3, which is part of the exocyst complex that is involved in the docking of exocytic vesicles with fusion sites on the plasma membrane

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sec6 pfam06046
Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 ...
 187-657 2.33e-149

Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localize to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis- independent manner.


:

Pssm-ID: 428738  Cd Length: 570  Bit Score: 444.48  E-value: 2.33e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493 187 FGSTQGLSDELAKQLWMVLQRSLVTVRRDPT-LLVSVVRIIEREEKIDRRILDRKKQTGF-----------VPPGRPKNW 254
Cdd:pfam06046   1 FSKVDGLIEKFDKLLWEIIRNLLELVREGNTsLVVRLARIVEREEKEDEKAEALREATKGhkdmatrfsinVFRRRPRGY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493 255 KEKMFAILDRTVTTRIEGTQADTRESDKmwlvrHLEIIR--KYVLDDLIVAKNLMVQCFPPHYEIFKNLLSMYHQALSTR 332
Cdd:pfam06046  81 KDKFLEALEESVEERFEECREKFSEDDK-----KLELLYnlDWVFDDLIVVKDLLAPLFPPHWKIFKTYANIYHNALHDL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493 333 MQDLA-SEDLEANEIVSLLTWVLnTYTSAEMMGNVELapEVDVSALEPLLSPNIVSELLDTYMSTLTSNIIAWLRKALET 411
Cdd:pfam06046 156 LQELVdSEELEAADILAILSWVK-TYYSKMMKGNPEL--EFDISDLGPLLGDEVLEELEDDYLSLIVNKMREWLDNLLET 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493 412 DKKDWSKETEP-EADQDGYYQTTLPAIVFQMFEQNLQVAAqisEDLKTKVLVLCLQQMNSFLSRYKDEAQLYKEEHLRNR 490
Cdd:pfam06046 233 EVKDFTEREEPpEEDLDGYYHLPLPVDVFQMLAEQVDVAA---DSLQAKILVGVLEELAKFLRSRQDAWIELLEEELKKY 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493 491 QH------PHCYVQYMIAIINNCQTFKESIISLKRKYLKTEAEEGLCLSQPSMDGILDAIAKEGCSSLLEEVFLDLEQHL 564
Cdd:pfam06046 310 MSvnnnesPPGLVEYLIALANDQLKCADYAESLLQKYEPLKYEERISDEFEELLDGLVDLSKECISALLDIIFNDLQPAL 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493 565 NELMTKKWlLGSNAVDIICVTVEDYFNDFAK-IKKPYKKRMTAEAHRRVVVEYLRAVMQKRISFrSAEERKEGAEKMVRE 643
Cdd:pfam06046 390 SKLFTKKW-YTGEVMEQIVETVEDYLNDYKEyLHPPLFQELLEELLDELVVEYLRALRGKRLKF-GAEKQEQFAEKMKRD 467

                         490
                  ....*....|....
gi 1039743493 644 AEQLRFLFRKLASR 657
Cdd:pfam06046 468 AEQLYDFFSKLGSR 481
 
Name Accession Description Interval E-value
Sec6 pfam06046
Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 ...
 187-657 2.33e-149

Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localize to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis- independent manner.


Pssm-ID: 428738  Cd Length: 570  Bit Score: 444.48  E-value: 2.33e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493 187 FGSTQGLSDELAKQLWMVLQRSLVTVRRDPT-LLVSVVRIIEREEKIDRRILDRKKQTGF-----------VPPGRPKNW 254
Cdd:pfam06046   1 FSKVDGLIEKFDKLLWEIIRNLLELVREGNTsLVVRLARIVEREEKEDEKAEALREATKGhkdmatrfsinVFRRRPRGY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493 255 KEKMFAILDRTVTTRIEGTQADTRESDKmwlvrHLEIIR--KYVLDDLIVAKNLMVQCFPPHYEIFKNLLSMYHQALSTR 332
Cdd:pfam06046  81 KDKFLEALEESVEERFEECREKFSEDDK-----KLELLYnlDWVFDDLIVVKDLLAPLFPPHWKIFKTYANIYHNALHDL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493 333 MQDLA-SEDLEANEIVSLLTWVLnTYTSAEMMGNVELapEVDVSALEPLLSPNIVSELLDTYMSTLTSNIIAWLRKALET 411
Cdd:pfam06046 156 LQELVdSEELEAADILAILSWVK-TYYSKMMKGNPEL--EFDISDLGPLLGDEVLEELEDDYLSLIVNKMREWLDNLLET 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493 412 DKKDWSKETEP-EADQDGYYQTTLPAIVFQMFEQNLQVAAqisEDLKTKVLVLCLQQMNSFLSRYKDEAQLYKEEHLRNR 490
Cdd:pfam06046 233 EVKDFTEREEPpEEDLDGYYHLPLPVDVFQMLAEQVDVAA---DSLQAKILVGVLEELAKFLRSRQDAWIELLEEELKKY 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493 491 QH------PHCYVQYMIAIINNCQTFKESIISLKRKYLKTEAEEGLCLSQPSMDGILDAIAKEGCSSLLEEVFLDLEQHL 564
Cdd:pfam06046 310 MSvnnnesPPGLVEYLIALANDQLKCADYAESLLQKYEPLKYEERISDEFEELLDGLVDLSKECISALLDIIFNDLQPAL 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493 565 NELMTKKWlLGSNAVDIICVTVEDYFNDFAK-IKKPYKKRMTAEAHRRVVVEYLRAVMQKRISFrSAEERKEGAEKMVRE 643
Cdd:pfam06046 390 SKLFTKKW-YTGEVMEQIVETVEDYLNDYKEyLHPPLFQELLEELLDELVVEYLRALRGKRLKF-GAEKQEQFAEKMKRD 467

                         490
                  ....*....|....
gi 1039743493 644 AEQLRFLFRKLASR 657
Cdd:pfam06046 468 AEQLYDFFSKLGSR 481
SEC6 COG5173
Exocyst complex subunit SEC6 [Intracellular trafficking and secretion];
73-627 7.88e-27

Exocyst complex subunit SEC6 [Intracellular trafficking and secretion];


Pssm-ID: 227500 [Multi-domain]  Cd Length: 742  Bit Score: 116.20  E-value: 7.88e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493  73 SQLHNALNDVKDIQQSLADVSK---DWRQSINTIESL-------KDVKDAVVQHSQLAAAVENLKNIFSVpeIVRETQDL 142
Cdd:COG5173    47 KCLNNILNISKRIYGLEEELKSlveGKRRNVRVLKGFfrlvkdyRSVKMTCLAHSNLCNVVEFSDRIEDI--LGTVLTED 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493 143 IEQGALLQAHRKLMDLECSRDGLMceqYRMDSGNKRDMTLIHGYFGSTQGLSDELAKQLwMVLQRSLVTVRRDP--TLLV 220
Cdd:COG5173   125 IDMPNLLAYHTKLYDARDFGEQLD---MYATEISHDDYVTVNKAFSTLEKNSLDFDALV-LEISEEIIENVKSGhiEAMD 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493 221 SVVRIIEREEKIDRRILDRKKQTGFVP-----PGRPKNwkEKMFAILDRTVTTRIEGTQADTRES------DKMWL---- 285
Cdd:COG5173   201 KIFKIVEKEEARDELTRKIRDAKSELPksqdnPVLKEF--YGMYRMYATRKTRKLKDFVIKSIEVsvkekfDRLRNeyif 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493 286 VRHLEIIRKYVLDDLIVAKNLMVQCFPPHYEIFKNLLSMYHQALSTRMQDLASEDLEANEIVSLLTWVLNTYTSAEmmgn 365
Cdd:COG5173   279 DNSGELNMDFIFKDLSFIRENISLSFPPFDNILTLYHNNYQECLLKLFTDEVTERLDAGEILAIIEFVGNYYNTIE---- 354

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493 366 vELAPEVdVSALEPLLSPNIVSELLDTYMSTLTSNIIAWLRKALETD-KKDWSKETEPEADQDGYYQTTLPAIVFQMFEQ 444
Cdd:COG5173   355 -SKFNFI-ADEVGGRLLDNETGELLEKYTKLAQEKLKEWVMNLTRIEvDKFYARNEEPSRDSDGKLVLPGTVSLFQMITQ 432

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493 445 NLQVAAQISedlKTKVLVLCLQQMNSFLSRYKDEAQLYKEEHLRNRQHPHC-------YVQYMIAIINN---CQTFKESI 514
Cdd:COG5173   433 QLEPIAFTN---RSDVVGIVFAHITRTITKYQEIWKSNLVEEMDKQFKSNPessspagLEEYLIAVGNDglkIAQYITSL 509

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493 515 ISLKRKYLKTEAEEGLCLS-QPSMDGILDaIAKEGCSSLLEEVFLDLEQHLNELMTKKWLLGSNAvDIICVTVEDYFNDF 593
Cdd:COG5173   510 PSNTFELITSEYENDEVKElGKTVDGFID-ILKASNTFLAEFIIYDCQPAIDKIFTDEWYGGSVT-KVIVDTLQDYLSDY 587

                         570       580       590
                  ....*....|....*....|....*....|....*
gi 1039743493 594 AKIKKPYK-KRMTAEAHRRVVVEYLRAVMQKRISF 627
Cdd:COG5173   588 QNTMSEYLfVTFIHELSMSIVIAYLKQLGRKRASI 622
 
Name Accession Description Interval E-value
Sec6 pfam06046
Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 ...
 187-657 2.33e-149

Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localize to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis- independent manner.


Pssm-ID: 428738  Cd Length: 570  Bit Score: 444.48  E-value: 2.33e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493 187 FGSTQGLSDELAKQLWMVLQRSLVTVRRDPT-LLVSVVRIIEREEKIDRRILDRKKQTGF-----------VPPGRPKNW 254
Cdd:pfam06046   1 FSKVDGLIEKFDKLLWEIIRNLLELVREGNTsLVVRLARIVEREEKEDEKAEALREATKGhkdmatrfsinVFRRRPRGY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493 255 KEKMFAILDRTVTTRIEGTQADTRESDKmwlvrHLEIIR--KYVLDDLIVAKNLMVQCFPPHYEIFKNLLSMYHQALSTR 332
Cdd:pfam06046  81 KDKFLEALEESVEERFEECREKFSEDDK-----KLELLYnlDWVFDDLIVVKDLLAPLFPPHWKIFKTYANIYHNALHDL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493 333 MQDLA-SEDLEANEIVSLLTWVLnTYTSAEMMGNVELapEVDVSALEPLLSPNIVSELLDTYMSTLTSNIIAWLRKALET 411
Cdd:pfam06046 156 LQELVdSEELEAADILAILSWVK-TYYSKMMKGNPEL--EFDISDLGPLLGDEVLEELEDDYLSLIVNKMREWLDNLLET 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493 412 DKKDWSKETEP-EADQDGYYQTTLPAIVFQMFEQNLQVAAqisEDLKTKVLVLCLQQMNSFLSRYKDEAQLYKEEHLRNR 490
Cdd:pfam06046 233 EVKDFTEREEPpEEDLDGYYHLPLPVDVFQMLAEQVDVAA---DSLQAKILVGVLEELAKFLRSRQDAWIELLEEELKKY 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493 491 QH------PHCYVQYMIAIINNCQTFKESIISLKRKYLKTEAEEGLCLSQPSMDGILDAIAKEGCSSLLEEVFLDLEQHL 564
Cdd:pfam06046 310 MSvnnnesPPGLVEYLIALANDQLKCADYAESLLQKYEPLKYEERISDEFEELLDGLVDLSKECISALLDIIFNDLQPAL 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493 565 NELMTKKWlLGSNAVDIICVTVEDYFNDFAK-IKKPYKKRMTAEAHRRVVVEYLRAVMQKRISFrSAEERKEGAEKMVRE 643
Cdd:pfam06046 390 SKLFTKKW-YTGEVMEQIVETVEDYLNDYKEyLHPPLFQELLEELLDELVVEYLRALRGKRLKF-GAEKQEQFAEKMKRD 467

                         490
                  ....*....|....
gi 1039743493 644 AEQLRFLFRKLASR 657
Cdd:pfam06046 468 AEQLYDFFSKLGSR 481
SEC6 COG5173
Exocyst complex subunit SEC6 [Intracellular trafficking and secretion];
73-627 7.88e-27

Exocyst complex subunit SEC6 [Intracellular trafficking and secretion];


Pssm-ID: 227500 [Multi-domain]  Cd Length: 742  Bit Score: 116.20  E-value: 7.88e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493  73 SQLHNALNDVKDIQQSLADVSK---DWRQSINTIESL-------KDVKDAVVQHSQLAAAVENLKNIFSVpeIVRETQDL 142
Cdd:COG5173    47 KCLNNILNISKRIYGLEEELKSlveGKRRNVRVLKGFfrlvkdyRSVKMTCLAHSNLCNVVEFSDRIEDI--LGTVLTED 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493 143 IEQGALLQAHRKLMDLECSRDGLMceqYRMDSGNKRDMTLIHGYFGSTQGLSDELAKQLwMVLQRSLVTVRRDP--TLLV 220
Cdd:COG5173   125 IDMPNLLAYHTKLYDARDFGEQLD---MYATEISHDDYVTVNKAFSTLEKNSLDFDALV-LEISEEIIENVKSGhiEAMD 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493 221 SVVRIIEREEKIDRRILDRKKQTGFVP-----PGRPKNwkEKMFAILDRTVTTRIEGTQADTRES------DKMWL---- 285
Cdd:COG5173   201 KIFKIVEKEEARDELTRKIRDAKSELPksqdnPVLKEF--YGMYRMYATRKTRKLKDFVIKSIEVsvkekfDRLRNeyif 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493 286 VRHLEIIRKYVLDDLIVAKNLMVQCFPPHYEIFKNLLSMYHQALSTRMQDLASEDLEANEIVSLLTWVLNTYTSAEmmgn 365
Cdd:COG5173   279 DNSGELNMDFIFKDLSFIRENISLSFPPFDNILTLYHNNYQECLLKLFTDEVTERLDAGEILAIIEFVGNYYNTIE---- 354

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493 366 vELAPEVdVSALEPLLSPNIVSELLDTYMSTLTSNIIAWLRKALETD-KKDWSKETEPEADQDGYYQTTLPAIVFQMFEQ 444
Cdd:COG5173   355 -SKFNFI-ADEVGGRLLDNETGELLEKYTKLAQEKLKEWVMNLTRIEvDKFYARNEEPSRDSDGKLVLPGTVSLFQMITQ 432

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493 445 NLQVAAQISedlKTKVLVLCLQQMNSFLSRYKDEAQLYKEEHLRNRQHPHC-------YVQYMIAIINN---CQTFKESI 514
Cdd:COG5173   433 QLEPIAFTN---RSDVVGIVFAHITRTITKYQEIWKSNLVEEMDKQFKSNPessspagLEEYLIAVGNDglkIAQYITSL 509

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743493 515 ISLKRKYLKTEAEEGLCLS-QPSMDGILDaIAKEGCSSLLEEVFLDLEQHLNELMTKKWLLGSNAvDIICVTVEDYFNDF 593
Cdd:COG5173   510 PSNTFELITSEYENDEVKElGKTVDGFID-ILKASNTFLAEFIIYDCQPAIDKIFTDEWYGGSVT-KVIVDTLQDYLSDY 587

                         570       580       590
                  ....*....|....*....|....*....|....*
gi 1039743493 594 AKIKKPYK-KRMTAEAHRRVVVEYLRAVMQKRISF 627
Cdd:COG5173   588 QNTMSEYLfVTFIHELSMSIVIAYLKQLGRKRASI 622
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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